FOXP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.40379464
2behavioral response to nicotine (GO:0035095)5.71312372
3negative regulation of axon guidance (GO:1902668)5.38533808
4cranial nerve morphogenesis (GO:0021602)5.18728121
5nucleobase catabolic process (GO:0046113)4.81637213
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.71502208
7central nervous system projection neuron axonogenesis (GO:0021952)4.62370065
8neuron cell-cell adhesion (GO:0007158)4.49192057
9axonal fasciculation (GO:0007413)4.26349970
10facial nerve structural organization (GO:0021612)4.16933181
11forebrain neuron differentiation (GO:0021879)4.12552866
12negative regulation of axon extension involved in axon guidance (GO:0048843)4.06390543
13regulation of axon guidance (GO:1902667)4.04675635
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.00286715
15regulation of synapse assembly (GO:0051963)3.95341776
16regulation of catecholamine metabolic process (GO:0042069)3.95297632
17regulation of dopamine metabolic process (GO:0042053)3.95297632
18neuronal action potential (GO:0019228)3.79085277
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.76338182
20dendritic spine morphogenesis (GO:0060997)3.71993191
21neuron recognition (GO:0008038)3.70180757
22cell migration in hindbrain (GO:0021535)3.69310203
23central nervous system neuron axonogenesis (GO:0021955)3.65127906
24cranial nerve structural organization (GO:0021604)3.60866004
25positive regulation of gastrulation (GO:2000543)3.60195326
26negative regulation of dendrite development (GO:2000171)3.59810708
27regulation of respiratory system process (GO:0044065)3.59696096
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58388132
29positive regulation of catecholamine secretion (GO:0033605)3.57787975
30vocalization behavior (GO:0071625)3.47779142
31limb bud formation (GO:0060174)3.46215003
32postsynaptic membrane organization (GO:0001941)3.45343168
33positive regulation of synapse assembly (GO:0051965)3.43497392
34gamma-aminobutyric acid transport (GO:0015812)3.37472620
35epithelial cilium movement (GO:0003351)3.37412838
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36039349
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36012061
38regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.33881562
39protein localization to synapse (GO:0035418)3.32810246
40epithelial cell differentiation involved in kidney development (GO:0035850)3.31110296
41presynaptic membrane assembly (GO:0097105)3.30579812
42regulation of action potential (GO:0098900)3.29845660
43regulation of respiratory gaseous exchange (GO:0043576)3.28291833
44water-soluble vitamin biosynthetic process (GO:0042364)3.27467371
45regulation of dopamine secretion (GO:0014059)3.26774041
46cell proliferation in forebrain (GO:0021846)3.26641878
47startle response (GO:0001964)3.25789747
48dendrite development (GO:0016358)3.23929846
49regulation of synapse organization (GO:0050807)3.23185210
50opioid receptor signaling pathway (GO:0038003)3.21970815
51glomerulus development (GO:0032835)3.21121918
52dopamine biosynthetic process (GO:0042416)3.20842924
53dopaminergic neuron differentiation (GO:0071542)3.16666310
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16218047
55positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.15814664
56somite development (GO:0061053)3.15525609
57cilium movement (GO:0003341)3.15476414
58protein localization to cilium (GO:0061512)3.15287467
59spinal cord association neuron differentiation (GO:0021527)3.09224556
60glutamate receptor signaling pathway (GO:0007215)3.08155839
61indolalkylamine metabolic process (GO:0006586)3.07838991
62regulation of axon extension involved in axon guidance (GO:0048841)3.07541920
63synaptic transmission, cholinergic (GO:0007271)3.07369859
64drinking behavior (GO:0042756)3.04618211
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04522675
66female gonad development (GO:0008585)3.04164454
67serotonin metabolic process (GO:0042428)3.02371889
68cilium or flagellum-dependent cell motility (GO:0001539)3.00006363
69neuromuscular synaptic transmission (GO:0007274)2.96565153
70response to pheromone (GO:0019236)2.96346263
71establishment of planar polarity (GO:0001736)2.94922367
72establishment of tissue polarity (GO:0007164)2.94922367
73protein polyglutamylation (GO:0018095)2.94604816
74retinal ganglion cell axon guidance (GO:0031290)2.94408171
75presynaptic membrane organization (GO:0097090)2.94364906
76synaptic transmission, glutamatergic (GO:0035249)2.93412393
77cerebellar Purkinje cell differentiation (GO:0021702)2.93293689
78regulation of glutamate receptor signaling pathway (GO:1900449)2.91985813
79regulation of synapse structural plasticity (GO:0051823)2.91044266
80interkinetic nuclear migration (GO:0022027)2.90554483
81regulation of glucokinase activity (GO:0033131)2.90292314
82regulation of hexokinase activity (GO:1903299)2.90292314
83* cerebellum development (GO:0021549)2.90099596
84lymphoid progenitor cell differentiation (GO:0002320)2.89156482
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87442343
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87265592
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86775270
88cranial nerve development (GO:0021545)2.86734911
89calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84553630
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.84278517
91negative regulation of mast cell activation (GO:0033004)2.83444150
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81789869
93primary amino compound metabolic process (GO:1901160)2.81506679
94neuron fate determination (GO:0048664)2.81215392
95retina layer formation (GO:0010842)2.80828471
96membrane depolarization during action potential (GO:0086010)2.80606064
97circadian sleep/wake cycle process (GO:0022410)2.80000859
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79726938
99cell differentiation in spinal cord (GO:0021515)2.77298301
100hippocampus development (GO:0021766)2.77139642
101negative regulation of axon extension (GO:0030517)2.74887641
102anatomical structure arrangement (GO:0048532)2.74646472
103hindbrain development (GO:0030902)2.74262470
104generation of neurons (GO:0048699)2.71789756
105neuron migration (GO:0001764)2.71713150
106kidney morphogenesis (GO:0060993)2.69775433
107action potential (GO:0001508)2.68408572
108primitive streak formation (GO:0090009)2.68336969
109negative regulation of myoblast differentiation (GO:0045662)2.68062887
110sympathetic nervous system development (GO:0048485)2.67951867
111axoneme assembly (GO:0035082)2.67782899
112axonemal dynein complex assembly (GO:0070286)2.67716858
113positive regulation of action potential (GO:0045760)2.67658517
114intraciliary transport (GO:0042073)2.65949238
115neurotransmitter-gated ion channel clustering (GO:0072578)2.64938792
116histamine secretion (GO:0001821)2.64686516
117indole-containing compound metabolic process (GO:0042430)2.62979028
118cell differentiation involved in kidney development (GO:0061005)2.62262197
119neuron-neuron synaptic transmission (GO:0007270)2.60499520
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60311082
121synapse assembly (GO:0007416)2.59364470
122cell differentiation in hindbrain (GO:0021533)2.59039784
123cerebral cortex radially oriented cell migration (GO:0021799)2.58899280
124proline transport (GO:0015824)2.58872745
125positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58029579
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58028613
127tryptophan catabolic process (GO:0006569)2.57729376
128indole-containing compound catabolic process (GO:0042436)2.57729376
129indolalkylamine catabolic process (GO:0046218)2.57729376
130regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.56567809
131neural tube formation (GO:0001841)2.56385139
132neuronal action potential propagation (GO:0019227)2.54988955
133dentate gyrus development (GO:0021542)2.54572641
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.54288220
135dendrite morphogenesis (GO:0048813)2.54106498
136cAMP catabolic process (GO:0006198)2.52861203
137spinal cord motor neuron differentiation (GO:0021522)2.52097241
138urinary tract smooth muscle contraction (GO:0014848)2.52007684
139prostate gland growth (GO:0060736)2.51485227
140nucleus localization (GO:0051647)2.50550585
141transmission of nerve impulse (GO:0019226)2.50539241
142negative chemotaxis (GO:0050919)2.50212490
143alanine transport (GO:0032328)2.50099167
144detection of light stimulus involved in visual perception (GO:0050908)2.49859319
145detection of light stimulus involved in sensory perception (GO:0050962)2.49859319
146behavioral response to ethanol (GO:0048149)2.49790554
147negative regulation of chemotaxis (GO:0050922)2.49727171
148neuron fate specification (GO:0048665)2.47950107
149negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.46410061
150cilium organization (GO:0044782)2.45709214
151peristalsis (GO:0030432)2.45672723
152photoreceptor cell maintenance (GO:0045494)2.45489344
153spinal cord development (GO:0021510)2.44212931
154determination of left/right symmetry (GO:0007368)2.44109632
155cilium morphogenesis (GO:0060271)2.44097393
156inner ear receptor stereocilium organization (GO:0060122)2.43231608
157sulfation (GO:0051923)2.42736002
158sensory perception of pain (GO:0019233)2.42717352
159nonmotile primary cilium assembly (GO:0035058)2.41291227
160cilium assembly (GO:0042384)2.40865979
161somite rostral/caudal axis specification (GO:0032525)2.40806015
162protein complex biogenesis (GO:0070271)2.40791970
163inositol phosphate catabolic process (GO:0071545)2.40714135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97430148
2GBX2_23144817_ChIP-Seq_PC3_Human4.40363629
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82026066
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65992666
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.65163738
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.51474337
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48666430
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45083117
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36218275
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.31124138
11TAF15_26573619_Chip-Seq_HEK293_Human2.30167584
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29328178
13* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28731300
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27599675
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27581687
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24323317
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24323317
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20907023
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17308113
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14462207
21* RNF2_27304074_Chip-Seq_NSC_Mouse2.07888498
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07357391
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04382905
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02899306
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.01664666
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00418799
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97365471
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96130473
29IGF1R_20145208_ChIP-Seq_DFB_Human1.95636385
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95381336
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91638439
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90514663
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88100790
34P300_19829295_ChIP-Seq_ESCs_Human1.80624891
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78614396
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76064546
37REST_21632747_ChIP-Seq_MESCs_Mouse1.72445944
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.72007451
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71322030
40* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68636293
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67142965
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66878089
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64271646
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60582565
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.55509306
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55066451
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50828990
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.47985334
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.46621143
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.45459553
51BCAT_22108803_ChIP-Seq_LS180_Human1.43669215
52* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43467220
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43241700
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43241700
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39947482
56CBP_20019798_ChIP-Seq_JUKART_Human1.39947482
57* SMAD4_21799915_ChIP-Seq_A2780_Human1.39547993
58TCF4_23295773_ChIP-Seq_U87_Human1.39508325
59AR_25329375_ChIP-Seq_VCAP_Human1.39265667
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38851167
61DROSHA_22980978_ChIP-Seq_HELA_Human1.38848385
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.37859178
63P53_22387025_ChIP-Seq_ESCs_Mouse1.37517573
64AR_21572438_ChIP-Seq_LNCaP_Human1.37331836
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36992690
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35034705
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.34727099
68ZNF274_21170338_ChIP-Seq_K562_Hela1.34221153
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32202979
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31076206
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28887121
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27393421
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26454525
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25590535
75FUS_26573619_Chip-Seq_HEK293_Human1.24640295
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23854852
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23446789
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.23286949
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.22533630
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22321207
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22205342
82RUNX2_22187159_ChIP-Seq_PCA_Human1.20688425
83* ER_23166858_ChIP-Seq_MCF-7_Human1.20090627
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18674049
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18409906
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.18362845
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.17659608
88VDR_22108803_ChIP-Seq_LS180_Human1.17557892
89P300_18555785_Chip-Seq_ESCs_Mouse1.17365799
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16800660
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16744393
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.16264957
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16112383
94* EWS_26573619_Chip-Seq_HEK293_Human1.15562357
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15270675
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.14703705
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.14068183
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.14041974
99TCF4_22108803_ChIP-Seq_LS180_Human1.13958918
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13818094
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13741174
102AHR_22903824_ChIP-Seq_MCF-7_Human1.11509795
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11309974
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10062697
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09797846
106TP53_22573176_ChIP-Seq_HFKS_Human1.08187178
107* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07636190
108STAT3_23295773_ChIP-Seq_U87_Human1.07316916
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07289542
110* SOX2_19829295_ChIP-Seq_ESCs_Human1.07049481
111* NANOG_19829295_ChIP-Seq_ESCs_Human1.07049481
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.06940748
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06901852
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06240277
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.06146886
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05438789
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.05280610
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04790105
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.04048971
120JUN_21703547_ChIP-Seq_K562_Human1.04013023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.00146688
2MP0000569_abnormal_digit_pigmentation3.96377259
3MP0002638_abnormal_pupillary_reflex3.69039616
4MP0000566_synostosis3.56352444
5MP0006276_abnormal_autonomic_nervous3.53162194
6MP0010386_abnormal_urinary_bladder3.30194130
7MP0000778_abnormal_nervous_system2.83975964
8MP0001188_hyperpigmentation2.74965604
9MP0002102_abnormal_ear_morphology2.74013761
10MP0003011_delayed_dark_adaptation2.62019715
11MP0003283_abnormal_digestive_organ2.51077003
12MP0005423_abnormal_somatic_nervous2.38047419
13MP0005409_darkened_coat_color2.31373965
14MP0002938_white_spotting2.31102324
15* MP0001529_abnormal_vocalization2.15461878
16* MP0003635_abnormal_synaptic_transmissio2.14536799
17MP0003122_maternal_imprinting2.14472184
18* MP0002063_abnormal_learning/memory/cond2.10479397
19MP0006292_abnormal_olfactory_placode2.08113838
20* MP0001486_abnormal_startle_reflex2.05356862
21MP0006072_abnormal_retinal_apoptosis2.02794776
22MP0009745_abnormal_behavioral_response1.92994950
23MP0002557_abnormal_social/conspecific_i1.87176838
24* MP0002572_abnormal_emotion/affect_behav1.86514757
25MP0003890_abnormal_embryonic-extraembry1.82974174
26MP0001968_abnormal_touch/_nociception1.81972425
27MP0002837_dystrophic_cardiac_calcinosis1.79875913
28MP0005551_abnormal_eye_electrophysiolog1.78693442
29MP0002184_abnormal_innervation1.77334103
30MP0005253_abnormal_eye_physiology1.75892831
31MP0002909_abnormal_adrenal_gland1.73595958
32MP0000538_abnormal_urinary_bladder1.73002281
33MP0003195_calcinosis1.72370878
34MP0002277_abnormal_respiratory_mucosa1.70163416
35MP0004885_abnormal_endolymph1.70002595
36MP0002928_abnormal_bile_duct1.58891465
37MP0000631_abnormal_neuroendocrine_gland1.58698122
38MP0001984_abnormal_olfaction1.58470506
39MP0005187_abnormal_penis_morphology1.57809738
40MP0002064_seizures1.57543629
41MP0002734_abnormal_mechanical_nocicepti1.56314614
42MP0005646_abnormal_pituitary_gland1.55284904
43MP0005645_abnormal_hypothalamus_physiol1.54293877
44MP0008877_abnormal_DNA_methylation1.54008650
45MP0005084_abnormal_gallbladder_morpholo1.52920790
46MP0010030_abnormal_orbit_morphology1.51889188
47MP0004270_analgesia1.48123481
48* MP0004859_abnormal_synaptic_plasticity1.47699053
49MP0003121_genomic_imprinting1.45957127
50MP0002751_abnormal_autonomic_nervous1.45493308
51MP0008995_early_reproductive_senescence1.44917589
52MP0008961_abnormal_basal_metabolism1.44464489
53MP0002272_abnormal_nervous_system1.43430441
54MP0004133_heterotaxia1.39621635
55MP0002234_abnormal_pharynx_morphology1.38281298
56MP0005174_abnormal_tail_pigmentation1.36793980
57MP0008789_abnormal_olfactory_epithelium1.36189030
58MP0005171_absent_coat_pigmentation1.33260465
59* MP0002067_abnormal_sensory_capabilities1.30588924
60MP0001485_abnormal_pinna_reflex1.30469269
61MP0009046_muscle_twitch1.30343008
62MP0005394_taste/olfaction_phenotype1.29033912
63MP0005499_abnormal_olfactory_system1.29033912
64MP0004742_abnormal_vestibular_system1.28806372
65MP0003941_abnormal_skin_development1.27362758
66MP0002653_abnormal_ependyma_morphology1.24657526
67MP0002735_abnormal_chemical_nociception1.24582705
68MP0001970_abnormal_pain_threshold1.23622657
69MP0003787_abnormal_imprinting1.22784495
70MP0003315_abnormal_perineum_morphology1.20815537
71MP0002160_abnormal_reproductive_system1.20354421
72MP0002736_abnormal_nociception_after1.17722420
73MP0002876_abnormal_thyroid_physiology1.17089844
74MP0000026_abnormal_inner_ear1.17054728
75MP0004811_abnormal_neuron_physiology1.14960904
76MP0003385_abnormal_body_wall1.14219687
77MP0001440_abnormal_grooming_behavior1.08872386
78* MP0002177_abnormal_outer_ear1.08359916
79MP0002733_abnormal_thermal_nociception1.07215264
80MP0005379_endocrine/exocrine_gland_phen1.06458391
81MP0000015_abnormal_ear_pigmentation1.04377815
82MP0005257_abnormal_intraocular_pressure1.04187225
83* MP0001905_abnormal_dopamine_level1.03907149
84MP0000955_abnormal_spinal_cord1.03706352
85* MP0002152_abnormal_brain_morphology1.03341542
86* MP0002882_abnormal_neuron_morphology1.03245530
87* MP0004924_abnormal_behavior1.02929552
88* MP0005386_behavior/neurological_phenoty1.02929552
89MP0009697_abnormal_copulation1.00022746
90MP0002282_abnormal_trachea_morphology0.99405094
91MP0005389_reproductive_system_phenotype0.98855895
92MP0005195_abnormal_posterior_eye0.98453336
93* MP0003861_abnormal_nervous_system0.98373907
94MP0001664_abnormal_digestion0.97437479
95MP0000049_abnormal_middle_ear0.96622957
96MP0009250_abnormal_appendicular_skeleto0.96259735
97MP0008872_abnormal_physiological_respon0.96085662
98MP0001502_abnormal_circadian_rhythm0.95627920
99MP0003938_abnormal_ear_development0.94301093
100MP0005503_abnormal_tendon_morphology0.91903730
101MP0002752_abnormal_somatic_nervous0.91681693
102MP0003136_yellow_coat_color0.89594796
103MP0000427_abnormal_hair_cycle0.89238556
104MP0002822_catalepsy0.88793982
105MP0004043_abnormal_pH_regulation0.86454086
106MP0001944_abnormal_pancreas_morphology0.86216372
107MP0003942_abnormal_urinary_system0.85112249
108MP0001986_abnormal_taste_sensitivity0.85073372
109MP0000647_abnormal_sebaceous_gland0.84857658
110MP0001963_abnormal_hearing_physiology0.84731262
111MP0002249_abnormal_larynx_morphology0.84154851
112MP0001501_abnormal_sleep_pattern0.84073251
113MP0002233_abnormal_nose_morphology0.83124993
114MP0003119_abnormal_digestive_system0.82289581
115MP0004142_abnormal_muscle_tone0.81337699
116MP0001919_abnormal_reproductive_system0.81051556
117MP0000013_abnormal_adipose_tissue0.80573252
118MP0002163_abnormal_gland_morphology0.79290526
119* MP0002066_abnormal_motor_capabilities/c0.78672390
120MP0004215_abnormal_myocardial_fiber0.78239980
121MP0005197_abnormal_uvea_morphology0.77869310
122MP0002116_abnormal_craniofacial_bone0.77649434
123MP0001286_abnormal_eye_development0.76454313
124MP0001177_atelectasis0.75565348
125MP0005391_vision/eye_phenotype0.75510153
126MP0000681_abnormal_thyroid_gland0.74860319
127* MP0003137_abnormal_impulse_conducting0.71946021
128MP0009379_abnormal_foot_pigmentation0.71393622
129MP0003937_abnormal_limbs/digits/tail_de0.69891525
130MP0004145_abnormal_muscle_electrophysio0.69055943

Predicted human phenotypes

RankGene SetZ-score
1Protruding tongue (HP:0010808)4.35694005
2True hermaphroditism (HP:0010459)4.17099245
3Limb dystonia (HP:0002451)3.93878364
4Chronic hepatic failure (HP:0100626)3.88894432
5Focal motor seizures (HP:0011153)3.70671284
6Cutaneous finger syndactyly (HP:0010554)3.36573653
7Abnormal hair whorl (HP:0010721)3.35854623
8Morphological abnormality of the middle ear (HP:0008609)3.34718235
9Type II lissencephaly (HP:0007260)3.33729652
10Febrile seizures (HP:0002373)3.26245268
11Tubulointerstitial nephritis (HP:0001970)3.12986214
12Abnormality of the renal cortex (HP:0011035)3.10283451
13Exotropia (HP:0000577)3.01036423
14Hypothermia (HP:0002045)3.00793228
15Broad-based gait (HP:0002136)2.98866579
16Cutaneous syndactyly (HP:0012725)2.86984201
17Pancreatic fibrosis (HP:0100732)2.82600710
18Congenital stationary night blindness (HP:0007642)2.69956624
19Renal cortical cysts (HP:0000803)2.67687642
20Occipital encephalocele (HP:0002085)2.63367534
21Fair hair (HP:0002286)2.63340493
22Cystic liver disease (HP:0006706)2.63269672
23Medial flaring of the eyebrow (HP:0010747)2.63183903
24Abnormal sex determination (HP:0012244)2.61848982
25Sex reversal (HP:0012245)2.61848982
26Gait imbalance (HP:0002141)2.60726291
27Prostate neoplasm (HP:0100787)2.60125282
28Specific learning disability (HP:0001328)2.59519112
29Tubulointerstitial abnormality (HP:0001969)2.59173270
30Hip dysplasia (HP:0001385)2.54993183
31Tented upper lip vermilion (HP:0010804)2.54001513
32Genetic anticipation (HP:0003743)2.53367761
33Pancreatic cysts (HP:0001737)2.48040796
34Abolished electroretinogram (ERG) (HP:0000550)2.47467880
35Myokymia (HP:0002411)2.46279365
36Midline defect of the nose (HP:0004122)2.46135012
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.44225870
38Methylmalonic acidemia (HP:0002912)2.42994852
39Acute necrotizing encephalopathy (HP:0006965)2.41957825
40Epileptic encephalopathy (HP:0200134)2.39669191
41Pendular nystagmus (HP:0012043)2.39223723
42Esotropia (HP:0000565)2.39074715
43Optic nerve coloboma (HP:0000588)2.37735608
44Abnormality of the intervertebral disk (HP:0005108)2.37355442
45Nephrogenic diabetes insipidus (HP:0009806)2.34029855
46Renal hypoplasia (HP:0000089)2.33265503
47Lissencephaly (HP:0001339)2.31293987
48Atelectasis (HP:0100750)2.29720001
49Large for gestational age (HP:0001520)2.29661302
50Congenital primary aphakia (HP:0007707)2.26046795
51Cerebellar dysplasia (HP:0007033)2.25261172
52Hyperventilation (HP:0002883)2.24977988
53Dialeptic seizures (HP:0011146)2.24344360
54Preaxial hand polydactyly (HP:0001177)2.24326045
55Intellectual disability, moderate (HP:0002342)2.23651527
56Failure to thrive in infancy (HP:0001531)2.22750415
57Retinal dysplasia (HP:0007973)2.22567104
58Vaginal atresia (HP:0000148)2.22546306
59Furrowed tongue (HP:0000221)2.22407494
60Progressive macrocephaly (HP:0004481)2.21346733
61Aplasia/Hypoplasia of the lens (HP:0008063)2.21225818
62Abnormal ciliary motility (HP:0012262)2.21028194
63Polyphagia (HP:0002591)2.20586825
64Anophthalmia (HP:0000528)2.20459297
65Severe visual impairment (HP:0001141)2.19732907
66Abnormality of midbrain morphology (HP:0002418)2.19340899
67Molar tooth sign on MRI (HP:0002419)2.19340899
68Genital tract atresia (HP:0001827)2.19175981
69Myelomeningocele (HP:0002475)2.18418756
70Increased corneal curvature (HP:0100692)2.16422427
71Keratoconus (HP:0000563)2.16422427
72Short tibia (HP:0005736)2.16421386
73Bile duct proliferation (HP:0001408)2.15861836
74Abnormal biliary tract physiology (HP:0012439)2.15861836
75Excessive salivation (HP:0003781)2.15493725
76Drooling (HP:0002307)2.15493725
77Tubulointerstitial fibrosis (HP:0005576)2.15477978
78Generalized hypopigmentation of hair (HP:0011358)2.15226916
79Epileptiform EEG discharges (HP:0011182)2.14907437
80Scrotal hypoplasia (HP:0000046)2.14574847
81Male pseudohermaphroditism (HP:0000037)2.14224304
82Nephronophthisis (HP:0000090)2.13939257
83Pachygyria (HP:0001302)2.13702532
84Heterochromia iridis (HP:0001100)2.13372084
85Focal seizures (HP:0007359)2.13359998
86Abnormality of the labia minora (HP:0012880)2.12460281
87Hypsarrhythmia (HP:0002521)2.12056349
88Oligodactyly (hands) (HP:0001180)2.11881319
89Progressive inability to walk (HP:0002505)2.11378265
90EEG with generalized epileptiform discharges (HP:0011198)2.10837952
91Hemiparesis (HP:0001269)2.09911782
92Blue irides (HP:0000635)2.09263953
93Amblyopia (HP:0000646)2.08957694
94Atonic seizures (HP:0010819)2.08620262
95Agitation (HP:0000713)2.07953275
96Bilateral microphthalmos (HP:0007633)2.07884803
97Postaxial foot polydactyly (HP:0001830)2.06922103
98Optic nerve hypoplasia (HP:0000609)2.06541865
99Absent/shortened dynein arms (HP:0200106)2.06540543
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.06540543
101Anencephaly (HP:0002323)2.05102109
102Attenuation of retinal blood vessels (HP:0007843)2.04830717
103High anterior hairline (HP:0009890)2.04231178
104Polydipsia (HP:0001959)2.03781725
105Abnormal drinking behavior (HP:0030082)2.03781725
106Narrow forehead (HP:0000341)2.03036451
107Absent eyebrow (HP:0002223)2.02200517
108Inability to walk (HP:0002540)2.02154250
109Narrow nasal bridge (HP:0000446)1.98246604
110Congenital, generalized hypertrichosis (HP:0004540)1.95679735
111Tubular atrophy (HP:0000092)1.95459246
112Bony spicule pigmentary retinopathy (HP:0007737)1.94865987
113Growth hormone deficiency (HP:0000824)1.94037630
114Acute encephalopathy (HP:0006846)1.93851334
115Anomalous pulmonary venous return (HP:0010772)1.93402935
116Abnormal rod and cone electroretinograms (HP:0008323)1.92608754
117Congenital hepatic fibrosis (HP:0002612)1.92596838
118Absence seizures (HP:0002121)1.91815096
119Macroglossia (HP:0000158)1.90771738
120Sleep apnea (HP:0010535)1.88677128
121Progressive cerebellar ataxia (HP:0002073)1.88456689
122Abnormal mitochondria in muscle tissue (HP:0008316)1.88364140
123Mitochondrial inheritance (HP:0001427)1.88216167
124Aplasia/hypoplasia of the uterus (HP:0008684)1.88036028
125Gaze-evoked nystagmus (HP:0000640)1.87785650
126Abnormality of the renal medulla (HP:0100957)1.87077929
127Absent speech (HP:0001344)1.87023344
128Intestinal atresia (HP:0011100)1.86987799
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.86663194
130Decreased circulating renin level (HP:0003351)1.85457378
131Tracheomalacia (HP:0002779)1.84369037
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83472115
133Abnormal respiratory epithelium morphology (HP:0012253)1.83067408
134Abnormal respiratory motile cilium morphology (HP:0005938)1.83067408
135Methylmalonic aciduria (HP:0012120)1.82717404
136Hyperglycinemia (HP:0002154)1.81957982
137Symphalangism affecting the phalanges of the hand (HP:0009773)1.81847935
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81831248
139Abnormality of the pulmonary veins (HP:0011718)1.81424959
140Fibular aplasia (HP:0002990)1.80902771
141Abnormality of vitamin B metabolism (HP:0004340)1.80373817
142Abnormality of macular pigmentation (HP:0008002)1.78299337
143Sclerocornea (HP:0000647)1.77196156
144Meningocele (HP:0002435)1.77149874
145Bifid tongue (HP:0010297)1.76492787
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75549126
147Hypoplasia of the brainstem (HP:0002365)1.75549126
148Postaxial hand polydactyly (HP:0001162)1.75454635
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70846892
150White forelock (HP:0002211)1.70509347
151Abnormal respiratory motile cilium physiology (HP:0012261)1.69247118
152Short foot (HP:0001773)1.68257757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.42843504
2FRK3.90628325
3ERBB33.80400791
4CASK3.54775036
5MARK13.31717069
6DYRK23.11000787
7BCR2.97962647
8PNCK2.58549370
9BMPR1B2.55050437
10TNIK2.54886691
11MAP2K72.54821949
12MAPK132.35136873
13NTRK22.34756634
14MAP4K22.30069875
15PINK12.19886581
16KSR11.98414799
17CDK191.92016921
18SIK21.84361813
19NTRK31.82402162
20MAPK151.74474629
21MAP3K41.69317540
22FGFR21.66687765
23STK161.59106040
24WNK31.56526692
25MINK11.54871117
26EPHB21.44759909
27NME11.42551175
28EPHA41.35823515
29INSRR1.35397241
30YES11.34912091
31UHMK11.33497675
32SGK2231.33213074
33SGK4941.33213074
34EIF2AK21.26563650
35IRAK21.25491775
36MUSK1.23281901
37PAK31.16977022
38WNK41.14229798
39CSNK1A1L1.10609483
40CAMK1D1.10328609
41EPHA31.07217220
42CAMK1G1.05122736
43MAP3K121.03967018
44MKNK21.02601584
45BRD41.02287482
46ADRBK21.02138588
47TLK11.00883348
48CAMKK20.99307265
49VRK10.98724821
50OXSR10.98339559
51BCKDK0.97645651
52TSSK60.97227833
53TRIM280.95403557
54MAP2K40.93218438
55SGK20.92404124
56ZAK0.89521520
57MKNK10.89213838
58BMPR20.87204566
59CDK50.86875637
60DYRK30.86217976
61IRAK40.85093101
62DYRK1A0.79612375
63ICK0.78880087
64STK390.74134326
65PRKCE0.72397844
66SRPK10.69934448
67OBSCN0.67546013
68PKN10.64963066
69ERBB20.64261073
70TAOK30.62543507
71PRKCG0.62309001
72FER0.61745145
73TYRO30.61363307
74WEE10.60356496
75CDK30.59039803
76NUAK10.57057080
77CAMK40.56306401
78TIE10.54929252
79IRAK10.53112371
80CDK180.52347666
81TXK0.52266732
82PLK20.52045385
83CAMK2B0.51986749
84CAMK2D0.51888520
85CAMK2A0.51832936
86NEK60.51631116
87ADRBK10.51118529
88CHUK0.51071182
89PRPF4B0.50897957
90ROCK10.50726245
91SIK10.50427278
92PHKG10.48547537
93PHKG20.48547537
94MAP3K90.47357716
95PRKCZ0.47315711
96GRK70.46700471
97ACVR1B0.46161902
98CSNK1A10.45876851
99TGFBR10.45314831
100SGK10.43454050
101CAMK10.42759497
102STK110.42532837
103GRK50.42320923
104CDK80.41574614
105GRK10.41436543
106RPS6KA50.41410185
107PRKACB0.41235831
108PRKAA10.40510408
109DAPK20.40382283
110MAPK90.39274977
111CCNB10.38193427
112STK38L0.37530296
113CSNK1D0.37206728
114DDR20.37086638
115MARK20.37007047
116PIK3CG0.36448666
117PRKCH0.34012622
118CAMK2G0.33819339
119PAK60.33707933
120CSF1R0.33461349
121PRKCA0.33038916
122PRKG10.32860140
123ERBB40.32771762
124CSNK1E0.31282023
125PTK2B0.30334790
126RPS6KB10.29524043
127TNK20.29512876
128PLK30.28756029
129RPS6KA20.28309154
130CSNK1G20.26539568
131PRKACA0.26073100
132AKT20.25578530
133CSNK1G10.25216892
134AKT10.24532586
135CSNK1G30.24245252
136CDK150.24134208
137MAPKAPK50.23289865
138DMPK0.22695097

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.65285871
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.82168490
3Axon guidance_Homo sapiens_hsa043602.35674353
4Morphine addiction_Homo sapiens_hsa050322.30678136
5Cocaine addiction_Homo sapiens_hsa050302.30620795
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25828745
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.19516908
8Glutamatergic synapse_Homo sapiens_hsa047242.18326545
9GABAergic synapse_Homo sapiens_hsa047272.06785062
10Protein export_Homo sapiens_hsa030602.05586911
11Olfactory transduction_Homo sapiens_hsa047401.99160384
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98806225
13Amphetamine addiction_Homo sapiens_hsa050311.95580358
14Serotonergic synapse_Homo sapiens_hsa047261.90739980
15Circadian entrainment_Homo sapiens_hsa047131.84076691
16Linoleic acid metabolism_Homo sapiens_hsa005911.79043854
17Selenocompound metabolism_Homo sapiens_hsa004501.78773187
18Taste transduction_Homo sapiens_hsa047421.76983087
19Basal cell carcinoma_Homo sapiens_hsa052171.76665692
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71043032
21Dopaminergic synapse_Homo sapiens_hsa047281.69503472
22Cholinergic synapse_Homo sapiens_hsa047251.65320156
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61819909
24Tryptophan metabolism_Homo sapiens_hsa003801.52906554
25Notch signaling pathway_Homo sapiens_hsa043301.49011516
26Phototransduction_Homo sapiens_hsa047441.47892886
27Synaptic vesicle cycle_Homo sapiens_hsa047211.44826044
28Hedgehog signaling pathway_Homo sapiens_hsa043401.39798133
29Wnt signaling pathway_Homo sapiens_hsa043101.39781110
30Nitrogen metabolism_Homo sapiens_hsa009101.38666865
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30237828
32Melanogenesis_Homo sapiens_hsa049161.28985365
33Insulin secretion_Homo sapiens_hsa049111.27378067
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24017150
35ErbB signaling pathway_Homo sapiens_hsa040121.21637283
36Caffeine metabolism_Homo sapiens_hsa002321.15957069
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15696210
38Calcium signaling pathway_Homo sapiens_hsa040201.15365513
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14804468
40Gap junction_Homo sapiens_hsa045401.14769858
41Type I diabetes mellitus_Homo sapiens_hsa049401.10139122
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.09293952
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08078589
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.07749111
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07389648
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07260610
47Alcoholism_Homo sapiens_hsa050341.06393901
48Propanoate metabolism_Homo sapiens_hsa006401.05888323
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05049492
50Long-term depression_Homo sapiens_hsa047301.04696832
51Long-term potentiation_Homo sapiens_hsa047201.03592781
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00117408
53Retinol metabolism_Homo sapiens_hsa008300.99830655
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98241057
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96352335
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96181067
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95980740
58Chemical carcinogenesis_Homo sapiens_hsa052040.95799976
59Oxytocin signaling pathway_Homo sapiens_hsa049210.94234482
60Autoimmune thyroid disease_Homo sapiens_hsa053200.93175073
61Circadian rhythm_Homo sapiens_hsa047100.92647626
62Renin secretion_Homo sapiens_hsa049240.90923965
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.90775389
64N-Glycan biosynthesis_Homo sapiens_hsa005100.90354531
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87019172
66Hippo signaling pathway_Homo sapiens_hsa043900.83330453
67Vibrio cholerae infection_Homo sapiens_hsa051100.82793789
68Salivary secretion_Homo sapiens_hsa049700.82320968
69GnRH signaling pathway_Homo sapiens_hsa049120.81583119
70ABC transporters_Homo sapiens_hsa020100.80078735
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79711670
72cAMP signaling pathway_Homo sapiens_hsa040240.77851102
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77190245
74Dorso-ventral axis formation_Homo sapiens_hsa043200.77135398
75Ovarian steroidogenesis_Homo sapiens_hsa049130.76281683
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74833285
77Peroxisome_Homo sapiens_hsa041460.73678047
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72995546
79Fanconi anemia pathway_Homo sapiens_hsa034600.72282430
80Collecting duct acid secretion_Homo sapiens_hsa049660.68415739
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66721318
82Oxidative phosphorylation_Homo sapiens_hsa001900.66394270
83Parkinsons disease_Homo sapiens_hsa050120.66111402
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66038914
85Ether lipid metabolism_Homo sapiens_hsa005650.64646485
86Butanoate metabolism_Homo sapiens_hsa006500.64110341
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63008762
88RNA polymerase_Homo sapiens_hsa030200.62286622
89Dilated cardiomyopathy_Homo sapiens_hsa054140.62204996
90Inositol phosphate metabolism_Homo sapiens_hsa005620.61475314
91Regulation of autophagy_Homo sapiens_hsa041400.59996086
92Basal transcription factors_Homo sapiens_hsa030220.59594639
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59418415
94Cardiac muscle contraction_Homo sapiens_hsa042600.59338486
95Choline metabolism in cancer_Homo sapiens_hsa052310.59150357
96Ras signaling pathway_Homo sapiens_hsa040140.59120665
97Phagosome_Homo sapiens_hsa041450.58836395
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58658735
99Alzheimers disease_Homo sapiens_hsa050100.58596412
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55354024
101Colorectal cancer_Homo sapiens_hsa052100.54550484
102MAPK signaling pathway_Homo sapiens_hsa040100.54156757
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53680840
104Huntingtons disease_Homo sapiens_hsa050160.52021611
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51000647
106MicroRNAs in cancer_Homo sapiens_hsa052060.50301343
107Steroid biosynthesis_Homo sapiens_hsa001000.49576052
108Folate biosynthesis_Homo sapiens_hsa007900.49281627
109Sulfur metabolism_Homo sapiens_hsa009200.49093723
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48931325
111RNA degradation_Homo sapiens_hsa030180.47417069
112Gastric acid secretion_Homo sapiens_hsa049710.46936320
113Sphingolipid metabolism_Homo sapiens_hsa006000.46568536
114beta-Alanine metabolism_Homo sapiens_hsa004100.45447269
115Starch and sucrose metabolism_Homo sapiens_hsa005000.45380424
116Fat digestion and absorption_Homo sapiens_hsa049750.44224090
117Arachidonic acid metabolism_Homo sapiens_hsa005900.43947821
118Pathways in cancer_Homo sapiens_hsa052000.43679541
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43495238
120Rap1 signaling pathway_Homo sapiens_hsa040150.42943443
121Metabolic pathways_Homo sapiens_hsa011000.42583088
122Endometrial cancer_Homo sapiens_hsa052130.42095606
123Histidine metabolism_Homo sapiens_hsa003400.41971338
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41398100
125Type II diabetes mellitus_Homo sapiens_hsa049300.40941912
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.40723481
127Rheumatoid arthritis_Homo sapiens_hsa053230.39596098
128African trypanosomiasis_Homo sapiens_hsa051430.39166767
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39096703
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37600506
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36880442
132Oocyte meiosis_Homo sapiens_hsa041140.36822499
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35362182
134Renal cell carcinoma_Homo sapiens_hsa052110.34192138
135Glycerolipid metabolism_Homo sapiens_hsa005610.34074232
136Allograft rejection_Homo sapiens_hsa053300.32970061
137TGF-beta signaling pathway_Homo sapiens_hsa043500.31864429
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29391487
139Purine metabolism_Homo sapiens_hsa002300.29296653
140Pancreatic secretion_Homo sapiens_hsa049720.27173305

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