FOXP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.49694900
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.49694900
3negative thymic T cell selection (GO:0045060)7.12434940
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.10100761
5positive regulation of gamma-delta T cell activation (GO:0046645)7.06237291
6negative T cell selection (GO:0043383)6.93979472
7response to interleukin-15 (GO:0070672)6.82241818
8positive thymic T cell selection (GO:0045059)6.64741978
9positive T cell selection (GO:0043368)6.39794157
10* regulation of regulatory T cell differentiation (GO:0045589)6.36287778
11T cell selection (GO:0045058)6.27332753
12cellular response to interleukin-15 (GO:0071350)6.11830651
13thymic T cell selection (GO:0045061)6.11312938
14* regulation of isotype switching to IgG isotypes (GO:0048302)6.04779800
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87172510
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.79614011
17T cell migration (GO:0072678)5.64681770
18regulation of gamma-delta T cell differentiation (GO:0045586)5.35442397
19leukocyte aggregation (GO:0070486)5.29215659
20* regulation of interleukin-2 biosynthetic process (GO:0045076)5.23658835
21positive regulation of interleukin-2 production (GO:0032743)5.18278369
22* T cell receptor signaling pathway (GO:0050852)5.11511016
23activated T cell proliferation (GO:0050798)5.08315618
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.01900690
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01900690
26histone H3-K4 trimethylation (GO:0080182)4.96450118
27T cell costimulation (GO:0031295)4.81742788
28viral transcription (GO:0019083)4.79855849
29regulation of gamma-delta T cell activation (GO:0046643)4.79135490
30lymphocyte costimulation (GO:0031294)4.77698233
31translational termination (GO:0006415)4.54406780
32* regulation of T cell tolerance induction (GO:0002664)4.38804152
33ribosomal small subunit biogenesis (GO:0042274)4.29866744
34* antigen receptor-mediated signaling pathway (GO:0050851)4.24535627
35antigen processing and presentation of endogenous antigen (GO:0019883)4.23374081
36regulation of alpha-beta T cell proliferation (GO:0046640)4.18900455
37mast cell activation (GO:0045576)4.07675860
38response to type I interferon (GO:0034340)4.06103624
39type I interferon signaling pathway (GO:0060337)4.03619194
40cellular response to type I interferon (GO:0071357)4.03619194
41* regulation of isotype switching (GO:0045191)3.91127151
42myeloid dendritic cell differentiation (GO:0043011)3.86712306
43maturation of SSU-rRNA (GO:0030490)3.85793218
44detection of bacterium (GO:0016045)3.84653849
45tumor necrosis factor-mediated signaling pathway (GO:0033209)3.84167452
46* tolerance induction (GO:0002507)3.76735417
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.75355606
48* regulation of interleukin-2 production (GO:0032663)3.74536998
49cotranslational protein targeting to membrane (GO:0006613)3.72830392
50CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.71722609
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68805502
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.67733353
53protein targeting to ER (GO:0045047)3.67250550
54mast cell activation involved in immune response (GO:0002279)3.67180020
55mast cell degranulation (GO:0043303)3.67180020
56interferon-gamma production (GO:0032609)3.65105328
57myeloid dendritic cell activation (GO:0001773)3.61587029
58cellular response to ethanol (GO:0071361)3.58672402
59T-helper cell differentiation (GO:0042093)3.55757434
60CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.55757434
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55258962
62* negative regulation of T cell mediated immunity (GO:0002710)3.54782380
63detection of other organism (GO:0098543)3.54655255
64translational elongation (GO:0006414)3.54126717
65cellular protein complex disassembly (GO:0043624)3.50774775
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.50644615
67regulation of natural killer cell mediated immunity (GO:0002715)3.50644615
68positive regulation of B cell differentiation (GO:0045579)3.50333904
69negative regulation of type 2 immune response (GO:0002829)3.49696739
70viral life cycle (GO:0019058)3.43453270
71negative regulation of erythrocyte differentiation (GO:0045647)3.42777765
72regulation of histone H3-K27 methylation (GO:0061085)3.42154212
73protein localization to endoplasmic reticulum (GO:0070972)3.38769337
74heterotypic cell-cell adhesion (GO:0034113)3.37987838
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36879354
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34689544
77regulation of T cell mediated cytotoxicity (GO:0001914)3.33523332
78antigen processing and presentation via MHC class Ib (GO:0002475)3.32416066
79ribosomal small subunit assembly (GO:0000028)3.30696495
80T cell proliferation (GO:0042098)3.27821347
81regulation of type I interferon-mediated signaling pathway (GO:0060338)3.27163475
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26147498
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24921259
84negative regulation of T-helper cell differentiation (GO:0045623)3.24921259
85NIK/NF-kappaB signaling (GO:0038061)3.23273162
86Peyers patch development (GO:0048541)3.23052576
87mucosal-associated lymphoid tissue development (GO:0048537)3.23052576
88* T cell homeostasis (GO:0043029)3.18999001
89* regulation of immunoglobulin production (GO:0002637)3.17450841
90regulation of T cell receptor signaling pathway (GO:0050856)3.16954641
91hypothalamus development (GO:0021854)3.16468205
92regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15820983
93histone H3-K4 methylation (GO:0051568)3.15306562
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15143624
95* regulation of tolerance induction (GO:0002643)3.14509675
96positive regulation of isotype switching (GO:0045830)3.12782080
97* alpha-beta T cell activation (GO:0046631)3.12543766
98negative regulation of innate immune response (GO:0045824)3.11920648
99ribosomal large subunit biogenesis (GO:0042273)3.11855425
100B cell receptor signaling pathway (GO:0050853)3.11245321
101alpha-beta T cell differentiation involved in immune response (GO:0002293)3.11054391
102alpha-beta T cell activation involved in immune response (GO:0002287)3.11054391
103T cell differentiation involved in immune response (GO:0002292)3.11054391
104germinal center formation (GO:0002467)3.09895539
105* positive regulation of tolerance induction (GO:0002645)3.09158448
106axon ensheathment in central nervous system (GO:0032291)3.06913493
107central nervous system myelination (GO:0022010)3.06913493
108modulation by virus of host process (GO:0019054)3.05970318
109signal complex assembly (GO:0007172)3.04380461
110positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.04006655
111modulation by symbiont of host cellular process (GO:0044068)3.03393800
112* CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.02719562
113negative regulation of interleukin-12 production (GO:0032695)3.02044294
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00996790
115translational initiation (GO:0006413)3.00153711
116* lymphocyte homeostasis (GO:0002260)3.00140082
117positive regulation of granulocyte differentiation (GO:0030854)3.00008374
118regulation of defense response to virus by virus (GO:0050690)2.99539967
119regulation of leukocyte mediated cytotoxicity (GO:0001910)2.99389029
120protein complex disassembly (GO:0043241)2.98492711
121* positive regulation of T cell activation (GO:0050870)2.95170947
122regulation of granulocyte differentiation (GO:0030852)2.92834877
123* regulation of alpha-beta T cell activation (GO:0046634)2.92551299
124positive regulation of immunoglobulin production (GO:0002639)2.91723528
125JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91406457
126* regulation of immunoglobulin mediated immune response (GO:0002889)2.90865035
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90849763
128* negative regulation of leukocyte mediated immunity (GO:0002704)2.89779355
129regulation of B cell receptor signaling pathway (GO:0050855)2.88036451
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87874580
131regulation of B cell differentiation (GO:0045577)2.87002927
132* alpha-beta T cell differentiation (GO:0046632)2.86816044
133* negative regulation of lymphocyte mediated immunity (GO:0002707)2.86777899
134positive regulation of DNA recombination (GO:0045911)2.86223727
135* T cell differentiation (GO:0030217)2.85943418
136regulation of T-helper 1 cell differentiation (GO:0045625)2.85346356
137* positive regulation of interleukin-4 production (GO:0032753)2.84947826
138* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.84188164
139cellular response to interleukin-4 (GO:0071353)2.84174362
140defense response to protozoan (GO:0042832)2.83795798
141leukocyte cell-cell adhesion (GO:0007159)2.82230734
142lymphocyte migration (GO:0072676)2.82031276
143positive regulation of cell killing (GO:0031343)2.80598568
144positive regulation of humoral immune response (GO:0002922)2.78521118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.28266214
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.50178399
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.51516078
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.24504365
5RUNX_20019798_ChIP-Seq_JUKART_Human4.16441868
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.51518499
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.19332553
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17939671
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.94623889
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92606933
11UTX_26944678_Chip-Seq_JUKART_Human2.90949906
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86253196
13MAF_26560356_Chip-Seq_TH1_Human2.83831245
14MYB_26560356_Chip-Seq_TH2_Human2.82145612
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.79622128
16AR_21572438_ChIP-Seq_LNCaP_Human2.67194469
17MYC_22102868_ChIP-Seq_BL_Human2.64917131
18MAF_26560356_Chip-Seq_TH2_Human2.56644264
19MYB_26560356_Chip-Seq_TH1_Human2.47888697
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40074645
21VDR_21846776_ChIP-Seq_THP-1_Human2.37534645
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11464503
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10466347
24CIITA_25753668_ChIP-Seq_RAJI_Human1.97257863
25TAF15_26573619_Chip-Seq_HEK293_Human1.96246507
26GATA3_27048872_Chip-Seq_THYMUS_Human1.88199892
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85760357
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.83134182
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79821928
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76168576
31VDR_24763502_ChIP-Seq_THP-1_Human1.74603912
32KDM2B_26808549_Chip-Seq_DND41_Human1.73999579
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73282636
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70921774
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69877884
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55671204
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50393249
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.48307595
39SPI1_23547873_ChIP-Seq_NB4_Human1.46679963
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45825823
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45097851
42LXR_22292898_ChIP-Seq_THP-1_Human1.45030201
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42307954
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41323021
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39282312
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35652757
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.35021339
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34839266
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.33966375
50TCF7_22412390_ChIP-Seq_EML_Mouse1.32465759
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.31750791
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23490121
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23317322
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22268750
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22262740
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16909567
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16812350
58* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16315392
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15458317
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14095065
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13968237
62BCL6_27268052_Chip-Seq_Bcells_Human1.13954922
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13097717
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12322806
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10883641
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.09382082
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06421927
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05686049
69BCOR_27268052_Chip-Seq_Bcells_Human1.05667142
70GATA3_26560356_Chip-Seq_TH2_Human1.04934074
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04800175
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.04279341
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03160090
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02999674
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02474023
76SCL_19346495_ChIP-Seq_HPC-7_Human1.02023152
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01072537
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99649522
79IRF8_21731497_ChIP-ChIP_J774_Mouse0.98542539
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98135597
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97310963
82P68_20966046_ChIP-Seq_HELA_Human0.97149938
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96375484
84NCOR1_26117541_ChIP-Seq_K562_Human0.94608361
85FOXP3_21729870_ChIP-Seq_TREG_Human0.93865495
86CTCF_26484167_Chip-Seq_Bcells_Mouse0.92807094
87SPI1_23127762_ChIP-Seq_K562_Human0.92515774
88EZH2_22144423_ChIP-Seq_EOC_Human0.92395007
89TP63_17297297_ChIP-ChIP_HaCaT_Human0.91795474
90VDR_23849224_ChIP-Seq_CD4+_Human0.91627886
91RACK7_27058665_Chip-Seq_MCF-7_Human0.91279767
92IRF8_27001747_Chip-Seq_BMDM_Mouse0.91065374
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91007590
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90657175
95* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89478767
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88541504
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88048067
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87768676
99ETS1_21867929_ChIP-Seq_TH2_Mouse0.87710234
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87407477
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.87264521
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.86738836
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85517926
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85422430
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.83870302
106TET1_21451524_ChIP-Seq_MESCs_Mouse0.83844794
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83535450
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83027237
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.82817777
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82345703
111XRN2_22483619_ChIP-Seq_HELA_Human0.81635734
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81630858
113RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80705547
114MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80644270
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80434570
116GATA1_22025678_ChIP-Seq_K562_Human0.80380817
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80034432
118ELK1_19687146_ChIP-ChIP_HELA_Human0.80005314
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79826005
120EST1_17652178_ChIP-ChIP_JURKAT_Human0.79219497
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78534652
122PU_27001747_Chip-Seq_BMDM_Mouse0.78057127
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77707361
124GABP_17652178_ChIP-ChIP_JURKAT_Human0.77099114
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76388303
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75531173
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75355546
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74402445
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72643216
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71243072
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.71076720
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70336051
133DROSHA_22980978_ChIP-Seq_HELA_Human0.70140221
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69355587
135ETS1_20019798_ChIP-Seq_JURKAT_Human0.68801616
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68213373
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.65425820
138PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65256538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.63594887
2MP0005671_abnormal_response_to3.75816354
3MP0003724_increased_susceptibility_to3.18397412
4MP0000685_abnormal_immune_system3.10808912
5* MP0001800_abnormal_humoral_immune2.87531566
6MP0003880_abnormal_central_pattern2.81839966
7MP0009333_abnormal_splenocyte_physiolog2.75633826
8MP0002396_abnormal_hematopoietic_system2.72534944
9MP0003303_peritoneal_inflammation2.72322805
10* MP0005000_abnormal_immune_tolerance2.66097196
11* MP0003866_abnormal_defecation2.64323062
12* MP0000703_abnormal_thymus_morphology2.59968596
13* MP0002723_abnormal_immune_serum2.59138545
14MP0009379_abnormal_foot_pigmentation2.58237724
15* MP0002420_abnormal_adaptive_immunity2.54601237
16* MP0001819_abnormal_immune_cell2.49816950
17* MP0002398_abnormal_bone_marrow2.42444630
18MP0002138_abnormal_hepatobiliary_system2.33194683
19* MP0005387_immune_system_phenotype2.32133806
20* MP0001790_abnormal_immune_system2.32133806
21MP0003300_gastrointestinal_ulcer2.15712511
22* MP0000716_abnormal_immune_system2.15135245
23MP0004381_abnormal_hair_follicle2.09819408
24* MP0002452_abnormal_antigen_presenting2.08304132
25MP0002166_altered_tumor_susceptibility2.05769894
26* MP0002722_abnormal_immune_system2.05468109
27MP0001835_abnormal_antigen_presentation2.00044537
28MP0005025_abnormal_response_to1.91598343
29MP0002933_joint_inflammation1.90231389
30* MP0002405_respiratory_system_inflammati1.88985302
31* MP0000689_abnormal_spleen_morphology1.88695659
32MP0000920_abnormal_myelination1.82248279
33MP0005409_darkened_coat_color1.75146183
34MP0003436_decreased_susceptibility_to1.71369554
35MP0006082_CNS_inflammation1.70584010
36* MP0002429_abnormal_blood_cell1.65167096
37* MP0002148_abnormal_hypersensitivity_rea1.62714927
38* MP0010155_abnormal_intestine_physiology1.62370477
39MP0002822_catalepsy1.61317687
40MP0005310_abnormal_salivary_gland1.59281259
41MP0002006_tumorigenesis1.55625141
42MP0003787_abnormal_imprinting1.50438255
43* MP0001873_stomach_inflammation1.49632068
44MP0001968_abnormal_touch/_nociception1.48722925
45MP0002419_abnormal_innate_immunity1.47672947
46MP0009785_altered_susceptibility_to1.38531300
47MP0005174_abnormal_tail_pigmentation1.35490941
48MP0002736_abnormal_nociception_after1.34470575
49MP0002254_reproductive_system_inflammat1.33939098
50MP0005423_abnormal_somatic_nervous1.32840449
51MP0002163_abnormal_gland_morphology1.24015487
52* MP0001845_abnormal_inflammatory_respons1.19432587
53MP0008057_abnormal_DNA_replication1.12839791
54MP0005075_abnormal_melanosome_morpholog1.11795575
55MP0003045_fibrosis1.10598801
56MP0001905_abnormal_dopamine_level1.09260841
57MP0004185_abnormal_adipocyte_glucose1.08462687
58MP0008874_decreased_physiological_sensi1.07679184
59* MP0000490_abnormal_crypts_of1.07134833
60MP0004742_abnormal_vestibular_system1.05899021
61MP0004142_abnormal_muscle_tone1.05847099
62MP0002064_seizures1.03994709
63MP0005451_abnormal_body_composition1.03044207
64* MP0004947_skin_inflammation1.00674644
65MP0002735_abnormal_chemical_nociception0.99709588
66* MP0002277_abnormal_respiratory_mucosa0.99438980
67* MP0001663_abnormal_digestive_system0.96980964
68MP0001853_heart_inflammation0.93763923
69MP0005464_abnormal_platelet_physiology0.93714046
70MP0002132_abnormal_respiratory_system0.93644794
71MP0009745_abnormal_behavioral_response0.93266883
72MP0009278_abnormal_bone_marrow0.92986255
73MP0003635_abnormal_synaptic_transmissio0.91582901
74MP0001348_abnormal_lacrimal_gland0.90825967
75MP0000778_abnormal_nervous_system0.90145495
76MP0003191_abnormal_cellular_cholesterol0.87565671
77MP0004859_abnormal_synaptic_plasticity0.86920994
78MP0002572_abnormal_emotion/affect_behav0.86681222
79MP0001486_abnormal_startle_reflex0.85740637
80MP0003806_abnormal_nucleotide_metabolis0.82564405
81MP0001970_abnormal_pain_threshold0.81785893
82MP0002998_abnormal_bone_remodeling0.81120947
83MP0008260_abnormal_autophagy0.80684737
84MP0004808_abnormal_hematopoietic_stem0.80492610
85MP0000015_abnormal_ear_pigmentation0.78731131
86MP0003453_abnormal_keratinocyte_physiol0.78639015
87* MP0008569_lethality_at_weaning0.77939945
88MP0002019_abnormal_tumor_incidence0.77938310
89* MP0005381_digestive/alimentary_phenotyp0.77023164
90MP0002693_abnormal_pancreas_physiology0.75665718
91MP0002272_abnormal_nervous_system0.75423383
92MP0002067_abnormal_sensory_capabilities0.75047834
93MP0001346_abnormal_lacrimal_gland0.74726270
94MP0001533_abnormal_skeleton_physiology0.74027634
95MP0001485_abnormal_pinna_reflex0.73899853
96* MP0008469_abnormal_protein_level0.73841674
97MP0002009_preneoplasia0.72785856
98MP0003448_altered_tumor_morphology0.72426283
99MP0001919_abnormal_reproductive_system0.67655624
100MP0006276_abnormal_autonomic_nervous0.67143091
101MP0005166_decreased_susceptibility_to0.65591795
102* MP0009763_increased_sensitivity_to0.65166539
103MP0009764_decreased_sensitivity_to0.64855932
104MP0008961_abnormal_basal_metabolism0.64737869
105MP0001529_abnormal_vocalization0.62896914
106MP0000604_amyloidosis0.62488369
107MP0002733_abnormal_thermal_nociception0.61986064
108* MP0001340_abnormal_eyelid_morphology0.61335577
109MP0005379_endocrine/exocrine_gland_phen0.59081868
110* MP0000609_abnormal_liver_physiology0.57616348
111MP0002796_impaired_skin_barrier0.57364759
112MP0000477_abnormal_intestine_morphology0.56985707
113MP0004510_myositis0.56208368
114MP0003828_pulmonary_edema0.55138356
115* MP0000465_gastrointestinal_hemorrhage0.54898260
116MP0005390_skeleton_phenotype0.54463411
117* MP0001851_eye_inflammation0.53812960
118MP0000249_abnormal_blood_vessel0.53524670
119MP0003122_maternal_imprinting0.52767286
120MP0001501_abnormal_sleep_pattern0.52282293
121MP0008004_abnormal_stomach_pH0.52181783
122MP0003121_genomic_imprinting0.51982090
123MP0009765_abnormal_xenobiotic_induced0.51921155
124MP0004270_analgesia0.51591075
125MP0000678_abnormal_parathyroid_gland0.51418561
126MP0005360_urolithiasis0.51395835
127MP0005076_abnormal_cell_differentiation0.49120689
128MP0002638_abnormal_pupillary_reflex0.48997908
129MP0003252_abnormal_bile_duct0.48993947
130MP0009840_abnormal_foam_cell0.48475310
131* MP0001216_abnormal_epidermal_layer0.48251560
132MP0000858_altered_metastatic_potential0.47773764
133MP0001986_abnormal_taste_sensitivity0.47348483
134MP0002136_abnormal_kidney_physiology0.46421403
135MP0002557_abnormal_social/conspecific_i0.45491474
136MP0004130_abnormal_muscle_cell0.45245810
137MP0005365_abnormal_bile_salt0.44938121
138MP0002928_abnormal_bile_duct0.44093614
139MP0002139_abnormal_hepatobiliary_system0.44089265
140* MP0009931_abnormal_skin_appearance0.43532627

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.75404524
2Abnormality of T cell number (HP:0011839)5.45352608
3Pustule (HP:0200039)5.13922215
4Chronic otitis media (HP:0000389)4.84964569
5Panhypogammaglobulinemia (HP:0003139)4.55109715
6IgM deficiency (HP:0002850)4.38354208
7Seborrheic dermatitis (HP:0001051)4.30133311
8Optic neuritis (HP:0100653)4.28550595
9Retrobulbar optic neuritis (HP:0100654)4.28550595
10Gastrointestinal infarctions (HP:0005244)4.28295492
11Elevated erythrocyte sedimentation rate (HP:0003565)4.15541838
12Abnormality of the fingertips (HP:0001211)4.10744404
13Orchitis (HP:0100796)4.06096292
14Abnormality of T cells (HP:0002843)3.96004302
15Recurrent bronchitis (HP:0002837)3.92722458
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.88567601
17Increased IgM level (HP:0003496)3.76376237
18Recurrent fungal infections (HP:0002841)3.76371603
19Recurrent bacterial skin infections (HP:0005406)3.67688359
20Chronic mucocutaneous candidiasis (HP:0002728)3.66956874
21Recurrent cutaneous fungal infections (HP:0011370)3.66956874
22Reticulocytopenia (HP:0001896)3.62905177
23Hypochromic anemia (HP:0001931)3.57883915
24Recurrent abscess formation (HP:0002722)3.47188673
25Stomatitis (HP:0010280)3.46499607
26Recurrent viral infections (HP:0004429)3.44848735
27Severe combined immunodeficiency (HP:0004430)3.44513682
28Chronic obstructive pulmonary disease (HP:0006510)3.33829985
29Obstructive lung disease (HP:0006536)3.33829985
30Sparse lateral eyebrow (HP:0005338)3.33112628
31Basal cell carcinoma (HP:0002671)3.30115986
32Mediastinal lymphadenopathy (HP:0100721)3.21995263
33Abnormality of eosinophils (HP:0001879)3.18279688
34Abnormality of cells of the erythroid lineage (HP:0012130)3.17237078
35Sensory axonal neuropathy (HP:0003390)3.15293349
36Macrocytic anemia (HP:0001972)3.13406793
37Eosinophilia (HP:0001880)3.13398082
38Keratoconjunctivitis sicca (HP:0001097)3.11641665
39Combined immunodeficiency (HP:0005387)3.10271144
40Abnormality of macrophages (HP:0004311)3.08233179
41Pulmonary embolism (HP:0002204)3.06653706
42Nasal polyposis (HP:0100582)3.00816872
43Papilledema (HP:0001085)2.96940797
44Chest pain (HP:0100749)2.95810800
45Abnormal hair whorl (HP:0010721)2.95758301
46Keratoconjunctivitis (HP:0001096)2.92756209
47Hypochromic microcytic anemia (HP:0004840)2.91778789
48* Autoimmune hemolytic anemia (HP:0001890)2.91576241
49Gangrene (HP:0100758)2.88758680
50Chronic diarrhea (HP:0002028)2.86806905
51Abnormal hemoglobin (HP:0011902)2.76699148
52Ureteral stenosis (HP:0000071)2.73295087
53IgG deficiency (HP:0004315)2.69244870
54Leukocytosis (HP:0001974)2.65045850
55Abnormal number of erythroid precursors (HP:0012131)2.62255478
56Gastrointestinal stroma tumor (HP:0100723)2.57756447
57Verrucae (HP:0200043)2.54237030
58Papilloma (HP:0012740)2.54237030
59Autoimmune thrombocytopenia (HP:0001973)2.53272735
60Pallor (HP:0000980)2.53147034
61Colitis (HP:0002583)2.52505302
62Abnormality of the prostate (HP:0008775)2.52226950
63Granulocytopenia (HP:0001913)2.51491910
64Abnormality of T cell physiology (HP:0011840)2.49984774
65Joint swelling (HP:0001386)2.46238188
66Partial agenesis of the corpus callosum (HP:0001338)2.44756493
67Epistaxis (HP:0000421)2.44682662
68Increased hepatocellular lipid droplets (HP:0006565)2.44173475
69Recurrent sinusitis (HP:0011108)2.42742706
70Anorexia (HP:0002039)2.41391823
71Cheilitis (HP:0100825)2.40759561
72Inflammation of the large intestine (HP:0002037)2.39346214
73Ureteral obstruction (HP:0006000)2.38475903
74Urticaria (HP:0001025)2.37112025
75Myositis (HP:0100614)2.35221919
76Microcytic anemia (HP:0001935)2.35034451
77Abnormality of the pleura (HP:0002103)2.32246775
78Abnormality of B cell number (HP:0010975)2.30834511
79B lymphocytopenia (HP:0010976)2.30834511
80Meningitis (HP:0001287)2.29089666
81Chronic sinusitis (HP:0011109)2.28604571
82Recurrent gram-negative bacterial infections (HP:0005420)2.28333402
83Parakeratosis (HP:0001036)2.28033508
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25450798
85Gingivitis (HP:0000230)2.23006629
86Hemoptysis (HP:0002105)2.22296505
87Glomerulopathy (HP:0100820)2.22291898
88Respiratory difficulties (HP:0002880)2.21377671
89Abnormality of the nasal mucosa (HP:0000433)2.21053777
90Agammaglobulinemia (HP:0004432)2.19992432
91Premature skin wrinkling (HP:0100678)2.19710094
92Acute hepatic failure (HP:0006554)2.18641172
93Exertional dyspnea (HP:0002875)2.17567952
94Renal Fanconi syndrome (HP:0001994)2.16946650
95Leukodystrophy (HP:0002415)2.15633232
96Lymphopenia (HP:0001888)2.15218493
97Gastrointestinal inflammation (HP:0004386)2.14241044
98Slow saccadic eye movements (HP:0000514)2.12493297
99Mitochondrial inheritance (HP:0001427)2.12380530
100Abnormality of the tricuspid valve (HP:0001702)2.11614994
101Abnormality of cells of the lymphoid lineage (HP:0012140)2.09130088
102Progressive inability to walk (HP:0002505)2.09106000
103Deep palmar crease (HP:0006191)2.07517312
104Hyperlipoproteinemia (HP:0010980)2.06935399
105Arterial thrombosis (HP:0004420)2.06517579
106Intestinal fistula (HP:0100819)2.04412483
107Stomach cancer (HP:0012126)2.03804417
108Bronchitis (HP:0012387)2.03756859
109Skin rash (HP:0000988)2.03598697
110Bronchiectasis (HP:0002110)1.98967679
111Pulmonary infiltrates (HP:0002113)1.98771859
112Broad-based gait (HP:0002136)1.98567749
113IgA deficiency (HP:0002720)1.98381420
114Skin ulcer (HP:0200042)1.95804531
115Concave nail (HP:0001598)1.94962456
116Recurrent skin infections (HP:0001581)1.94796693
117Arthralgia (HP:0002829)1.93766895
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92928434
119Polygenic inheritance (HP:0010982)1.92820990
120Abnormality of the pericardium (HP:0001697)1.91167803
121Emphysema (HP:0002097)1.91153529
122Anal stenosis (HP:0002025)1.90486088
123Vasculitis (HP:0002633)1.89137595
124Restrictive lung disease (HP:0002091)1.88688171
125Acne (HP:0001061)1.88086884
126Spontaneous hematomas (HP:0007420)1.87907415
127Partial duplication of thumb phalanx (HP:0009944)1.87436450
128Lymphoma (HP:0002665)1.86526621
129Plagiocephaly (HP:0001357)1.85007645
130Abnormality of the fetal cardiovascular system (HP:0010948)1.84036084
131Abnormal umbilical cord blood vessels (HP:0011403)1.84036084
132Single umbilical artery (HP:0001195)1.84036084
133Lipid accumulation in hepatocytes (HP:0006561)1.83591906
134Abnormality of oral frenula (HP:0000190)1.83500901
135Encephalitis (HP:0002383)1.83103949
136Increased IgE level (HP:0003212)1.82844914
137Aplasia/Hypoplasia of the thymus (HP:0010515)1.82385561
138Hypergammaglobulinemia (HP:0010702)1.81309166
139Eczematoid dermatitis (HP:0000976)1.77501921
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77261379
141Prolonged bleeding time (HP:0003010)1.75960882
142Pulmonary fibrosis (HP:0002206)1.75107511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.43519862
2MAP4K14.19617728
3FGFR43.19526359
4TLK12.90297095
5TYK22.87868720
6JAK32.79945295
7ITK2.64879610
8SIK22.49161257
9IKBKE2.32386292
10FES2.26264549
11* LCK2.21574844
12STK102.20303235
13ZAP702.19018569
14GRK62.18678029
15SIK32.08081492
16MAP3K132.06443044
17TYRO32.00828048
18TRIB31.99181103
19NTRK21.95340205
20PASK1.84922700
21FGFR21.83643118
22RIPK41.81298134
23SMG11.74239647
24NLK1.67130968
25BLK1.62481522
26TAOK31.60046494
27PRKCQ1.59346750
28JAK11.56300277
29FGFR31.55881568
30MARK31.50041910
31TNIK1.46362143
32NME11.45806591
33CSK1.45724610
34JAK21.43796215
35NME21.42870767
36SIK11.33265481
37MAP3K141.32051713
38SYK1.29692063
39HCK1.24907506
40CASK1.22496611
41STK391.21310224
42PNCK1.19452913
43CDK121.19306667
44ERN11.18426210
45MARK21.17596778
46TAOK11.15185862
47CAMKK11.14210521
48MAP2K31.12132800
49CLK11.10702069
50PKN11.09501843
51CAMKK21.07015825
52MAPK151.06197949
53UHMK11.03946212
54PRKD20.97230871
55TESK20.97138435
56PRKCH0.94732079
57CDK190.94144508
58MAP3K70.92613999
59MAPK120.88407821
60MAPK110.87481626
61DYRK1A0.85520817
62EPHB10.85078260
63EPHA30.84873613
64CDK40.84375169
65IRAK20.82450665
66MAP3K110.81181065
67MAP3K10.80910032
68YES10.80710228
69IRAK40.76347823
70PDGFRB0.75212056
71TAOK20.74635408
72CSNK1A1L0.72431773
73TNK20.70922874
74KIT0.68762143
75PBK0.66405657
76LYN0.64768809
77MAP3K120.64619235
78OXSR10.64267354
79CAMK2B0.62283781
80TEC0.61920830
81PTK60.61364082
82MST40.60600591
83FYN0.59674416
84IRAK10.59587797
85HIPK20.57871116
86PDK10.57620463
87MAP3K30.55459922
88CSNK1G10.53031214
89CHUK0.52990557
90FGR0.51007565
91IRAK30.50748977
92KDR0.46525792
93IKBKB0.45794045
94MAPK40.45752410
95TBK10.45597425
96MAP3K100.45125100
97BTK0.43119058
98ROCK20.42661654
99MAPK70.42437961
100RPS6KL10.41836124
101RPS6KC10.41836124
102CSNK1G30.38656721
103RPS6KA50.37166352
104STK110.37093518
105PRPF4B0.36758834
106RPS6KA60.36552522
107MAP2K20.36477964
108DYRK1B0.35310722
109BRD40.35243528
110EGFR0.34733576
111CDK80.34382779
112MAP2K60.33584140
113SRC0.33263475
114MAPKAPK20.32936103
115BUB10.32800827
116STK40.32043108
117WNK10.28725194
118INSR0.27863516
119CDC42BPA0.27546870
120CSF1R0.26439357
121CDK60.25899783
122MKNK20.25807518
123CDK90.25737560
124RET0.25553937
125CDK50.24959516
126SRPK10.24185148
127MAPK30.23211658
128PRKG10.23031233
129IGF1R0.22896844
130MELK0.22625891
131MAPK90.22543168
132PIM10.21033609
133LRRK20.20461825
134ABL10.20307377
135PRKD10.19814400
136PDPK10.19774535
137CAMK40.18997363
138KSR20.18954966

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.93025908
2Ribosome_Homo sapiens_hsa030103.91622403
3T cell receptor signaling pathway_Homo sapiens_hsa046603.86684305
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.38291562
5Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.36391332
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.30991329
7Measles_Homo sapiens_hsa051622.16117664
8Oxidative phosphorylation_Homo sapiens_hsa001901.97209794
9Type I diabetes mellitus_Homo sapiens_hsa049401.96274299
10* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89902950
11Hematopoietic cell lineage_Homo sapiens_hsa046401.89868996
12Autoimmune thyroid disease_Homo sapiens_hsa053201.65429868
13TNF signaling pathway_Homo sapiens_hsa046681.64303212
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59489995
15Parkinsons disease_Homo sapiens_hsa050121.57172341
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.56377838
17Alzheimers disease_Homo sapiens_hsa050101.53912345
18Spliceosome_Homo sapiens_hsa030401.43186636
19Allograft rejection_Homo sapiens_hsa053301.41602402
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.41534973
21Osteoclast differentiation_Homo sapiens_hsa043801.34978360
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30863711
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25749336
24Viral myocarditis_Homo sapiens_hsa054161.22940437
25Chemokine signaling pathway_Homo sapiens_hsa040621.19876807
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19668580
27Platelet activation_Homo sapiens_hsa046111.19274952
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17986130
29B cell receptor signaling pathway_Homo sapiens_hsa046621.17840205
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17645226
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15415326
32Long-term depression_Homo sapiens_hsa047301.15277481
33Leishmaniasis_Homo sapiens_hsa051401.13760432
34African trypanosomiasis_Homo sapiens_hsa051431.05977737
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04642072
36Viral carcinogenesis_Homo sapiens_hsa052031.01405564
37Apoptosis_Homo sapiens_hsa042101.00196817
38Antigen processing and presentation_Homo sapiens_hsa046121.00174132
39Tuberculosis_Homo sapiens_hsa051520.98417909
40Choline metabolism in cancer_Homo sapiens_hsa052310.97228836
41RNA polymerase_Homo sapiens_hsa030200.94359964
42VEGF signaling pathway_Homo sapiens_hsa043700.92695576
43Huntingtons disease_Homo sapiens_hsa050160.91564601
44Non-homologous end-joining_Homo sapiens_hsa034500.91546828
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90365223
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89040366
47Herpes simplex infection_Homo sapiens_hsa051680.88776663
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.87385371
49Hepatitis B_Homo sapiens_hsa051610.85645238
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84560071
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82465301
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.81758059
53Long-term potentiation_Homo sapiens_hsa047200.80281986
54Acute myeloid leukemia_Homo sapiens_hsa052210.78791679
55FoxO signaling pathway_Homo sapiens_hsa040680.75984830
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.75968810
57Renal cell carcinoma_Homo sapiens_hsa052110.74865000
58Cholinergic synapse_Homo sapiens_hsa047250.74527869
59Glutamatergic synapse_Homo sapiens_hsa047240.74460494
60Malaria_Homo sapiens_hsa051440.73790839
61Notch signaling pathway_Homo sapiens_hsa043300.73734621
62Other glycan degradation_Homo sapiens_hsa005110.73706058
63Renin secretion_Homo sapiens_hsa049240.73609756
64Protein export_Homo sapiens_hsa030600.72882023
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.72504301
66Rheumatoid arthritis_Homo sapiens_hsa053230.72178886
67Graft-versus-host disease_Homo sapiens_hsa053320.71572125
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71017279
69Morphine addiction_Homo sapiens_hsa050320.69973008
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.69800853
71Pancreatic cancer_Homo sapiens_hsa052120.69768621
72HTLV-I infection_Homo sapiens_hsa051660.68971635
73Hepatitis C_Homo sapiens_hsa051600.64814299
74Epstein-Barr virus infection_Homo sapiens_hsa051690.64365266
75Salivary secretion_Homo sapiens_hsa049700.64313423
76Gastric acid secretion_Homo sapiens_hsa049710.64207438
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64044149
78Insulin resistance_Homo sapiens_hsa049310.64039015
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64011412
80Serotonergic synapse_Homo sapiens_hsa047260.62140883
81Toxoplasmosis_Homo sapiens_hsa051450.61971661
82Pertussis_Homo sapiens_hsa051330.61446764
83Shigellosis_Homo sapiens_hsa051310.59754103
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59662217
85Axon guidance_Homo sapiens_hsa043600.59482718
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59143870
87Homologous recombination_Homo sapiens_hsa034400.58788771
88Inositol phosphate metabolism_Homo sapiens_hsa005620.57908826
89Prolactin signaling pathway_Homo sapiens_hsa049170.57357646
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57054867
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56037970
92MAPK signaling pathway_Homo sapiens_hsa040100.55171295
93Endometrial cancer_Homo sapiens_hsa052130.54983922
94Asthma_Homo sapiens_hsa053100.54805553
95Legionellosis_Homo sapiens_hsa051340.54748132
96ErbB signaling pathway_Homo sapiens_hsa040120.54518086
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54406989
98Ras signaling pathway_Homo sapiens_hsa040140.53859780
99mTOR signaling pathway_Homo sapiens_hsa041500.53670294
100Nicotine addiction_Homo sapiens_hsa050330.52873632
101Cardiac muscle contraction_Homo sapiens_hsa042600.52799558
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.52058833
103Influenza A_Homo sapiens_hsa051640.50933700
104Colorectal cancer_Homo sapiens_hsa052100.50329517
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50218919
106Caffeine metabolism_Homo sapiens_hsa002320.50213020
107Rap1 signaling pathway_Homo sapiens_hsa040150.46251740
108GnRH signaling pathway_Homo sapiens_hsa049120.46196521
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.45388766
110Ether lipid metabolism_Homo sapiens_hsa005650.44699746
111Non-small cell lung cancer_Homo sapiens_hsa052230.44501272
112Staphylococcus aureus infection_Homo sapiens_hsa051500.44408490
113Dopaminergic synapse_Homo sapiens_hsa047280.43439537
114Sphingolipid metabolism_Homo sapiens_hsa006000.43420065
115Chronic myeloid leukemia_Homo sapiens_hsa052200.43375469
116Thyroid cancer_Homo sapiens_hsa052160.42187961
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40870761
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38842976
119RNA degradation_Homo sapiens_hsa030180.38345713
120Endocytosis_Homo sapiens_hsa041440.38341004
121Prostate cancer_Homo sapiens_hsa052150.37917426
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37763505
123Prion diseases_Homo sapiens_hsa050200.36867643
124Oxytocin signaling pathway_Homo sapiens_hsa049210.35512890
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.31236533
126Linoleic acid metabolism_Homo sapiens_hsa005910.30276858
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.29590351
128HIF-1 signaling pathway_Homo sapiens_hsa040660.25589063
129Dorso-ventral axis formation_Homo sapiens_hsa043200.25108925
130Small cell lung cancer_Homo sapiens_hsa052220.22030852
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19705688
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17811836
133ABC transporters_Homo sapiens_hsa020100.16846628
134Circadian rhythm_Homo sapiens_hsa047100.16807087
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16752557
136Sulfur relay system_Homo sapiens_hsa041220.15804199

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