FOXP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell junction maintenance (GO:0045217)4.62912316
2lung epithelium development (GO:0060428)4.24332331
3desmosome organization (GO:0002934)4.14009588
4pre-miRNA processing (GO:0031054)4.09830265
5heterochromatin organization (GO:0070828)3.96077418
6semaphorin-plexin signaling pathway (GO:0071526)3.87593232
7positive regulation of histone deacetylation (GO:0031065)3.85542935
8embryonic retina morphogenesis in camera-type eye (GO:0060059)3.74785398
9cell junction maintenance (GO:0034331)3.69999556
10epithelial cell-cell adhesion (GO:0090136)3.63039059
11establishment of apical/basal cell polarity (GO:0035089)3.60579647
12basement membrane organization (GO:0071711)3.58937221
13atrioventricular valve morphogenesis (GO:0003181)3.57350903
14regulation of translational fidelity (GO:0006450)3.56469931
15activation of Rac GTPase activity (GO:0032863)3.54409797
16regulation of cholesterol biosynthetic process (GO:0045540)3.52165078
17polarized epithelial cell differentiation (GO:0030859)3.49236714
18antigen processing and presentation of endogenous antigen (GO:0019883)3.45465472
19endothelial cell chemotaxis (GO:0035767)3.44178050
20protein retention in ER lumen (GO:0006621)3.42401064
21regulation of hippo signaling (GO:0035330)3.40186922
22protein carboxylation (GO:0018214)3.39529602
23peptidyl-glutamic acid carboxylation (GO:0017187)3.39529602
24intracellular estrogen receptor signaling pathway (GO:0030520)3.39250786
25maternal placenta development (GO:0001893)3.36083107
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.35911584
27regulation of extracellular matrix disassembly (GO:0010715)3.35360782
28planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32993819
29branching involved in mammary gland duct morphogenesis (GO:0060444)3.32318882
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32135868
31trophectodermal cell differentiation (GO:0001829)3.31890630
32insulin-like growth factor receptor signaling pathway (GO:0048009)3.29104564
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28668399
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28668399
35RNA stabilization (GO:0043489)3.26397901
36mRNA stabilization (GO:0048255)3.26397901
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.26292866
38positive thymic T cell selection (GO:0045059)3.21948513
39glucocorticoid receptor signaling pathway (GO:0042921)3.18533730
40convergent extension (GO:0060026)3.10449245
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.08673121
42regulation of glucose import in response to insulin stimulus (GO:2001273)3.07702518
43dosage compensation (GO:0007549)3.07158022
44regulation of gamma-delta T cell differentiation (GO:0045586)3.04144693
45NIK/NF-kappaB signaling (GO:0038061)3.01502313
46apoptotic process involved in morphogenesis (GO:0060561)2.98848585
47regulation of NFAT protein import into nucleus (GO:0051532)2.98457505
48regulation of apoptotic cell clearance (GO:2000425)2.97866966
49establishment or maintenance of monopolar cell polarity (GO:0061339)2.96684628
50establishment of monopolar cell polarity (GO:0061162)2.96684628
51proline metabolic process (GO:0006560)2.93537700
52negative regulation of cell size (GO:0045792)2.91913532
53regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89345314
54epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89106294
55corticosteroid receptor signaling pathway (GO:0031958)2.88093001
56ear development (GO:0043583)2.86221074
57regulation of integrin activation (GO:0033623)2.84460569
58proline biosynthetic process (GO:0006561)2.84196622
59peptidyl-lysine dimethylation (GO:0018027)2.83053641
60NLS-bearing protein import into nucleus (GO:0006607)2.81790583
61negative regulation of RNA splicing (GO:0033119)2.81652564
62regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80093281
63cell proliferation involved in metanephros development (GO:0072203)2.79517649
64regulation of bile acid biosynthetic process (GO:0070857)2.77888121
65protein-DNA complex disassembly (GO:0032986)2.77376753
66nucleosome disassembly (GO:0006337)2.77376753
67regulation of fatty acid beta-oxidation (GO:0031998)2.76613052
68adherens junction assembly (GO:0034333)2.74024870
69cytoplasmic mRNA processing body assembly (GO:0033962)2.73630539
70regulation of early endosome to late endosome transport (GO:2000641)2.72029520
71regulation of posttranscriptional gene silencing (GO:0060147)2.71760471
72regulation of gene silencing by miRNA (GO:0060964)2.71760471
73regulation of gene silencing by RNA (GO:0060966)2.71760471
74hippo signaling (GO:0035329)2.70873356
75regulation of gamma-delta T cell activation (GO:0046643)2.70795502
76negative regulation of erythrocyte differentiation (GO:0045647)2.70734915
77regulation of extracellular matrix organization (GO:1903053)2.70632079
78negative regulation of mRNA processing (GO:0050686)2.69290307
79positive regulation of gamma-delta T cell activation (GO:0046645)2.68772148
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.68434492
81cochlea morphogenesis (GO:0090103)2.68241339
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67540705
83negative regulation of mRNA metabolic process (GO:1903312)2.66177841
84negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65446047
85positive regulation of protein deacetylation (GO:0090312)2.65254368
86negative regulation of catenin import into nucleus (GO:0035414)2.65200386
87thymic T cell selection (GO:0045061)2.64861762
88folic acid-containing compound biosynthetic process (GO:0009396)2.64288657
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64286205
90intestinal cholesterol absorption (GO:0030299)2.62545617
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62400300
92positive regulation of gene expression, epigenetic (GO:0045815)2.62209140
93regulation of cholesterol metabolic process (GO:0090181)2.61476360
94regulation of histone H3-K27 methylation (GO:0061085)2.59689687
95plasma lipoprotein particle assembly (GO:0034377)2.59005829
96mannose metabolic process (GO:0006013)2.58914739
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.57451632
98renal system development (GO:0072001)2.57215983
99positive regulation of nuclease activity (GO:0032075)2.56757661
100regulation of cholesterol homeostasis (GO:2000188)2.56690941
101natural killer cell differentiation (GO:0001779)2.56422546
102cell proliferation involved in kidney development (GO:0072111)2.55901126
103negative regulation of fatty acid transport (GO:2000192)2.55017321
104endothelial tube morphogenesis (GO:0061154)2.55009942
105morphogenesis of an endothelium (GO:0003159)2.55009942
1063-UTR-mediated mRNA stabilization (GO:0070935)2.54180323
107nuclear pore complex assembly (GO:0051292)2.53600261
108positive regulation of RNA splicing (GO:0033120)2.53186908
109apoptotic process involved in development (GO:1902742)2.52624485
110positive regulation of fatty acid beta-oxidation (GO:0032000)2.51702106
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51523144
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.51079553
113regulation of ARF GTPase activity (GO:0032312)2.50536556
114peptidyl-arginine omega-N-methylation (GO:0035247)2.50154835
115positive regulation of steroid biosynthetic process (GO:0010893)2.49927427
116negative regulation of fibrinolysis (GO:0051918)2.49272706
117hemidesmosome assembly (GO:0031581)2.49150164
118embryonic eye morphogenesis (GO:0048048)2.48630883
119embryonic camera-type eye morphogenesis (GO:0048596)2.47645304
120cell-substrate junction assembly (GO:0007044)2.47325772
121low-density lipoprotein particle clearance (GO:0034383)2.47134310
122embryonic skeletal joint morphogenesis (GO:0060272)2.45953466
123negative regulation of viral release from host cell (GO:1902187)2.45893650
124cell volume homeostasis (GO:0006884)2.45830949
125paraxial mesoderm development (GO:0048339)2.45776285
126negative regulation of histone methylation (GO:0031061)2.45613165
127positive regulation of synapse maturation (GO:0090129)2.45297509
128negative regulation of glial cell proliferation (GO:0060253)2.44690590
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44583900
130cellular response to epidermal growth factor stimulus (GO:0071364)2.44485404
131positive regulation of CREB transcription factor activity (GO:0032793)2.43342101
132nodal signaling pathway (GO:0038092)2.42386502
133histone H2A monoubiquitination (GO:0035518)2.41838874
134regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.41772385
135focal adhesion assembly (GO:0048041)2.41317996
136cell-substrate adherens junction assembly (GO:0007045)2.41317996
137protein localization to kinetochore (GO:0034501)2.41203979
138positive regulation of hormone metabolic process (GO:0032352)2.40193939
139regulation of translational termination (GO:0006449)2.39492355
140chromatin assembly (GO:0031497)2.39414427
141regulation of nuclease activity (GO:0032069)2.38336815
142epithelial cell fate commitment (GO:0072148)2.38084829
143growth hormone receptor signaling pathway (GO:0060396)2.37767701
144T cell apoptotic process (GO:0070231)2.37040038
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.36749689
146bone morphogenesis (GO:0060349)2.36723148
147non-canonical Wnt signaling pathway (GO:0035567)2.36464203
148protein-lipid complex assembly (GO:0065005)2.36379484
149nuclear pore organization (GO:0006999)2.36078040
150regulation of chromatin binding (GO:0035561)2.35695606
151regulation of establishment of planar polarity (GO:0090175)2.35579428
152exocrine pancreas development (GO:0031017)2.35381324
153anatomical structure regression (GO:0060033)2.35139748
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.34543418
155glucose 6-phosphate metabolic process (GO:0051156)2.34053738
156COPI coating of Golgi vesicle (GO:0048205)2.33396115
157Golgi transport vesicle coating (GO:0048200)2.33396115
158RNA localization (GO:0006403)2.32839358
159peptidyl-arginine methylation (GO:0018216)2.32357150
160peptidyl-arginine N-methylation (GO:0035246)2.32357150
161regulation of mRNA stability (GO:0043488)2.32081513
162regulation of SMAD protein import into nucleus (GO:0060390)2.31756255
163camera-type eye morphogenesis (GO:0048593)2.31563104
164neural tube development (GO:0021915)2.31491509
165pattern specification involved in kidney development (GO:0061004)2.30629644
166peptidyl-tyrosine autophosphorylation (GO:0038083)2.30312976
167cellular response to pH (GO:0071467)2.29830646
168regulation of RNA export from nucleus (GO:0046831)2.29684307
169DNA unwinding involved in DNA replication (GO:0006268)2.29433051
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29294742
171response to UV-C (GO:0010225)2.29065983
172negative thymic T cell selection (GO:0045060)2.26579039
173receptor catabolic process (GO:0032801)2.25874104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.91463427
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.68783098
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.66000477
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.50200401
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.37561777
6E2F7_22180533_ChIP-Seq_HELA_Human2.76710012
7VDR_21846776_ChIP-Seq_THP-1_Human2.69479022
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65521913
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.55276782
10TCF7_22412390_ChIP-Seq_EML_Mouse2.50858829
11* KDM2B_26808549_Chip-Seq_DND41_Human2.48138780
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.47540021
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32806589
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.32230295
15* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.25517932
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19129879
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13083745
18LXR_22292898_ChIP-Seq_THP-1_Human2.11377431
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06497618
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98648989
21* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90729720
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.88933119
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.87528537
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85790221
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.85707619
26MAF_26560356_Chip-Seq_TH1_Human1.79974524
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79899310
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76996814
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.72527278
30UTX_26944678_Chip-Seq_JUKART_Human1.72126977
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70416799
32* SMC4_20622854_ChIP-Seq_HELA_Human1.67640240
33KDM2B_26808549_Chip-Seq_K562_Human1.64916457
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64026308
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.63314929
36* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61847480
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59425982
38ZNF263_19887448_ChIP-Seq_K562_Human1.59052009
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58430152
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58244361
41CTCF_27219007_Chip-Seq_Bcells_Human1.57520029
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57167647
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51723043
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51368906
45ATF3_27146783_Chip-Seq_COLON_Human1.51119261
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48720951
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48686534
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48108258
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.47346686
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47086957
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46823818
52CREB1_26743006_Chip-Seq_LNCaP_Human1.43848663
53* NCOR1_26117541_ChIP-Seq_K562_Human1.43570717
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.42610972
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42133910
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42055630
57* VDR_24763502_ChIP-Seq_THP-1_Human1.41882170
58* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41149101
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38462257
60CLOCK_20551151_ChIP-Seq_293T_Human1.36134857
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35849350
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35584304
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35319881
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34546319
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31467630
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31237300
67* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26463640
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26259926
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24586343
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.24510279
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24478203
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23594448
73MAF_26560356_Chip-Seq_TH2_Human1.23501843
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23462970
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23462970
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23462970
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22494444
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22411907
79* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21575726
80DROSHA_22980978_ChIP-Seq_HELA_Human1.20869080
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19935432
82BCOR_27268052_Chip-Seq_Bcells_Human1.19843572
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19810156
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19023137
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.18609078
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18557975
87GATA6_25053715_ChIP-Seq_YYC3_Human1.18383734
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17817493
89* TP63_22573176_ChIP-Seq_HFKS_Human1.16993505
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16559732
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16424212
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16334210
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16281813
94* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15916103
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.14553313
96CIITA_25753668_ChIP-Seq_RAJI_Human1.14477512
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14108938
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13415264
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12813931
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12496967
101TP53_22127205_ChIP-Seq_IMR90_Human1.11678633
102CHD1_26751641_Chip-Seq_LNCaP_Human1.11672877
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11051466
104P68_20966046_ChIP-Seq_HELA_Human1.10989501
105* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10755580
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.10218722
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10061406
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.09100704
109BCL6_27268052_Chip-Seq_Bcells_Human1.08601472
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.08281902
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.07825196
112MYB_26560356_Chip-Seq_TH1_Human1.07239092
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06626062
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06526024
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06400401
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05503895
117* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03461198
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03381523
119PHF8_20622854_ChIP-Seq_HELA_Human1.01569737
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01499105
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01230876
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01180732
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.01171127
124* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00720581
125KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00297251
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00249655
127* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00045109
128* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99680705
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98835750
130* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98587353
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97594161
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97583050
133MYB_26560356_Chip-Seq_TH2_Human0.97322745
134NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96630303
135E2F1_20622854_ChIP-Seq_HELA_Human0.96479177
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95538872
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95431926
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.95243167
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.95107271
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.94933384
141POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93885722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.35263400
2MP0003705_abnormal_hypodermis_morpholog3.74695583
3MP0005076_abnormal_cell_differentiation3.35809041
4MP0002249_abnormal_larynx_morphology3.04670376
5MP0010352_gastrointestinal_tract_polyps2.97270870
6MP0005409_darkened_coat_color2.85974093
7MP0002254_reproductive_system_inflammat2.56163876
8MP0003300_gastrointestinal_ulcer2.52099135
9MP0005670_abnormal_white_adipose2.48594859
10MP0005058_abnormal_lysosome_morphology2.32336608
11MP0003303_peritoneal_inflammation2.23758694
12MP0001348_abnormal_lacrimal_gland2.19714626
13MP0009278_abnormal_bone_marrow2.19318377
14MP0000685_abnormal_immune_system2.14221305
15MP0010030_abnormal_orbit_morphology2.12143960
16MP0001849_ear_inflammation2.07967037
17MP0010234_abnormal_vibrissa_follicle2.05967837
18MP0003283_abnormal_digestive_organ2.03264523
19MP0005451_abnormal_body_composition2.03042178
20MP0009053_abnormal_anal_canal2.01234212
21MP0000537_abnormal_urethra_morphology1.92181806
22MP0003172_abnormal_lysosome_physiology1.89098536
23MP0003566_abnormal_cell_adhesion1.88352505
24MP0005360_urolithiasis1.84623868
25MP0008961_abnormal_basal_metabolism1.83493149
26MP0002653_abnormal_ependyma_morphology1.82441462
27MP0002877_abnormal_melanocyte_morpholog1.75737914
28MP0002139_abnormal_hepatobiliary_system1.72154551
29MP0000733_abnormal_muscle_development1.66083895
30MP0004197_abnormal_fetal_growth/weight/1.58780050
31MP0004264_abnormal_extraembryonic_tissu1.53513328
32MP0005377_hearing/vestibular/ear_phenot1.51686589
33MP0003878_abnormal_ear_physiology1.51686589
34MP0009780_abnormal_chondrocyte_physiolo1.50414851
35MP0002098_abnormal_vibrissa_morphology1.49489674
36MP0005023_abnormal_wound_healing1.47330866
37MP0005375_adipose_tissue_phenotype1.45293853
38MP0010329_abnormal_lipoprotein_level1.43868183
39MP0005666_abnormal_adipose_tissue1.42479507
40MP0003453_abnormal_keratinocyte_physiol1.40945581
41MP0001666_abnormal_nutrient_absorption1.40038441
42MP0005365_abnormal_bile_salt1.39889558
43MP0002084_abnormal_developmental_patter1.36238016
44MP0005623_abnormal_meninges_morphology1.33809836
45MP0000350_abnormal_cell_proliferation1.32909663
46MP0002086_abnormal_extraembryonic_tissu1.31295925
47MP0004510_myositis1.31134557
48MP0000428_abnormal_craniofacial_morphol1.30399986
49MP0003091_abnormal_cell_migration1.30013370
50MP0001730_embryonic_growth_arrest1.29442913
51* MP0003119_abnormal_digestive_system1.26742986
52MP0002085_abnormal_embryonic_tissue1.24794117
53MP0001672_abnormal_embryogenesis/_devel1.22711349
54MP0005380_embryogenesis_phenotype1.22711349
55MP0001873_stomach_inflammation1.22596603
56MP0002088_abnormal_embryonic_growth/wei1.22366088
57MP0000462_abnormal_digestive_system1.22012404
58MP0003984_embryonic_growth_retardation1.21462021
59MP0003123_paternal_imprinting1.21228939
60MP0002796_impaired_skin_barrier1.20831969
61MP0004947_skin_inflammation1.19645350
62MP0003763_abnormal_thymus_physiology1.16514311
63MP0002116_abnormal_craniofacial_bone1.15387291
64MP0008438_abnormal_cutaneous_collagen1.13004381
65MP0001697_abnormal_embryo_size1.12076239
66MP0003122_maternal_imprinting1.11744344
67MP0004185_abnormal_adipocyte_glucose1.11483214
68MP0001790_abnormal_immune_system1.11459983
69MP0005387_immune_system_phenotype1.11459983
70MP0004858_abnormal_nervous_system1.10738737
71* MP0003115_abnormal_respiratory_system1.10692321
72MP0004957_abnormal_blastocyst_morpholog1.08896067
73MP0009384_cardiac_valve_regurgitation1.08231196
74MP0000703_abnormal_thymus_morphology1.08227435
75MP0010155_abnormal_intestine_physiology1.06578979
76MP0009333_abnormal_splenocyte_physiolog1.05794433
77MP0010307_abnormal_tumor_latency1.05245364
78MP0000678_abnormal_parathyroid_gland1.05231709
79MP0002896_abnormal_bone_mineralization1.04869163
80MP0003866_abnormal_defecation1.04863955
81MP0003879_abnormal_hair_cell1.04485745
82MP0003436_decreased_susceptibility_to1.03907750
83MP0004808_abnormal_hematopoietic_stem1.02541399
84MP0000767_abnormal_smooth_muscle1.02080778
85MP0002932_abnormal_joint_morphology1.01822086
86MP0003385_abnormal_body_wall1.01629930
87MP0003938_abnormal_ear_development1.01347247
88MP0003942_abnormal_urinary_system1.00998661
89MP0002396_abnormal_hematopoietic_system1.00978627
90MP0000490_abnormal_crypts_of0.99935264
91* MP0002925_abnormal_cardiovascular_devel0.99816043
92MP0003935_abnormal_craniofacial_develop0.99007535
93MP0000467_abnormal_esophagus_morphology0.97736503
94MP0005248_abnormal_Harderian_gland0.96846646
95MP0000534_abnormal_ureter_morphology0.96829537
96* MP0002080_prenatal_lethality0.96805955
97MP0002405_respiratory_system_inflammati0.96159275
98MP0002138_abnormal_hepatobiliary_system0.94709239
99MP0003045_fibrosis0.94446695
100MP0008057_abnormal_DNA_replication0.94247124
101MP0003890_abnormal_embryonic-extraembry0.94111221
102MP0001346_abnormal_lacrimal_gland0.93434042
103MP0000477_abnormal_intestine_morphology0.93302273
104MP0003111_abnormal_nucleus_morphology0.93265989
105MP0001800_abnormal_humoral_immune0.92783710
106MP0009672_abnormal_birth_weight0.92436127
107MP0005501_abnormal_skin_physiology0.92306496
108MP0004381_abnormal_hair_follicle0.91930781
109MP0002166_altered_tumor_susceptibility0.90800911
110MP0003183_abnormal_peptide_metabolism0.89556981
111MP0002398_abnormal_bone_marrow0.89229424
112MP0003077_abnormal_cell_cycle0.88685241
113MP0002092_abnormal_eye_morphology0.88568308
114MP0006054_spinal_hemorrhage0.87904360
115MP0009703_decreased_birth_body0.87475262
116MP0002697_abnormal_eye_size0.87248767
117MP0005397_hematopoietic_system_phenotyp0.86188149
118MP0001545_abnormal_hematopoietic_system0.86188149
119MP0001944_abnormal_pancreas_morphology0.85275222
120MP0002234_abnormal_pharynx_morphology0.85066175
121MP0002970_abnormal_white_adipose0.82952649
122MP0005367_renal/urinary_system_phenotyp0.82734487
123MP0000516_abnormal_urinary_system0.82734487
124MP0002111_abnormal_tail_morphology0.82482997
125MP0002060_abnormal_skin_morphology0.81854207
126MP0005508_abnormal_skeleton_morphology0.81161231
127MP0009840_abnormal_foam_cell0.80520591
128MP0005257_abnormal_intraocular_pressure0.80150296
129MP0008770_decreased_survivor_rate0.79660487
130MP0001915_intracranial_hemorrhage0.79444843
131MP0000470_abnormal_stomach_morphology0.79351431
132MP0000858_altered_metastatic_potential0.77872700
133MP0002089_abnormal_postnatal_growth/wei0.77713895
134MP0000762_abnormal_tongue_morphology0.77421573
135MP0003567_abnormal_fetal_cardiomyocyte0.77203554
136MP0005310_abnormal_salivary_gland0.76982697
137MP0010630_abnormal_cardiac_muscle0.76837264
138MP0004233_abnormal_muscle_weight0.76793040
139MP0005220_abnormal_exocrine_pancreas0.76120496
140MP0000579_abnormal_nail_morphology0.76064410
141MP0004782_abnormal_surfactant_physiolog0.75900554
142MP0000003_abnormal_adipose_tissue0.75547090
143MP0004272_abnormal_basement_membrane0.75436433
144MP0001270_distended_abdomen0.73804230
145MP0002933_joint_inflammation0.73639119
146MP0001340_abnormal_eyelid_morphology0.73384842
147MP0009115_abnormal_fat_cell0.72454473
148MP0002118_abnormal_lipid_homeostasis0.71426506
149MP0000751_myopathy0.70706719
150MP0006138_congestive_heart_failure0.68716078
151MP0000163_abnormal_cartilage_morphology0.68201276
152MP0001216_abnormal_epidermal_layer0.67563412
153MP0000609_abnormal_liver_physiology0.67234993
154MP0003861_abnormal_nervous_system0.66991124
155MP0002909_abnormal_adrenal_gland0.66820366
156MP0009931_abnormal_skin_appearance0.65750659
157MP0000377_abnormal_hair_follicle0.64794693
158MP0005408_hypopigmentation0.64387304
159MP0010678_abnormal_skin_adnexa0.63461854
160MP0000432_abnormal_head_morphology0.62388812
161MP0002113_abnormal_skeleton_development0.62042261
162MP0000681_abnormal_thyroid_gland0.62006388

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.37990577
2Obstructive sleep apnea (HP:0002870)3.73056878
3Hyperacusis (HP:0010780)3.55116891
4Broad face (HP:0000283)3.39280777
5Asymmetry of the thorax (HP:0001555)3.28798263
6Hemorrhage of the eye (HP:0011885)3.22376871
7Shallow orbits (HP:0000586)3.17322426
8Renal duplication (HP:0000075)3.11881618
9Cerebral aneurysm (HP:0004944)3.06671803
10Bronchomalacia (HP:0002780)2.91481021
11Ulnar bowing (HP:0003031)2.90696240
12Protrusio acetabuli (HP:0003179)2.86524722
13Abnormality of the aortic arch (HP:0012303)2.80199640
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59437441
15Short 4th metacarpal (HP:0010044)2.59437441
16Abnormality of the fingertips (HP:0001211)2.54548173
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50710700
18Advanced eruption of teeth (HP:0006288)2.42859561
19Rectal prolapse (HP:0002035)2.40018724
20Flattened epiphyses (HP:0003071)2.38943870
21Disproportionate tall stature (HP:0001519)2.33964389
22Increased density of long bones (HP:0006392)2.30763133
23Abnormality of the gastric mucosa (HP:0004295)2.28303323
24Pseudobulbar signs (HP:0002200)2.27458070
25Neonatal short-limb short stature (HP:0008921)2.26841793
26Broad thumb (HP:0011304)2.25812585
27Elfin facies (HP:0004428)2.25350382
28Hand muscle atrophy (HP:0009130)2.24184385
29Abnormality of the 4th metacarpal (HP:0010012)2.24094277
30Mitral valve prolapse (HP:0001634)2.22524869
31Distal upper limb amyotrophy (HP:0007149)2.22093500
32Upper limb amyotrophy (HP:0009129)2.22093500
33Ependymoma (HP:0002888)2.19779484
34Macroorchidism (HP:0000053)2.19483175
35Renovascular hypertension (HP:0100817)2.14067529
36Bowing of the arm (HP:0006488)2.13325826
37Bowed forearm bones (HP:0003956)2.13325826
38Aneurysm (HP:0002617)2.11959026
39Hypercortisolism (HP:0001578)2.08232370
40Premature skin wrinkling (HP:0100678)2.07338033
41Milia (HP:0001056)2.07009370
42Genu recurvatum (HP:0002816)2.06021719
43Deviation of the hallux (HP:0010051)2.05274335
44Hallux valgus (HP:0001822)2.04574565
45Interstitial pulmonary disease (HP:0006530)2.04128283
46Skin tags (HP:0010609)2.01631269
47Right ventricular cardiomyopathy (HP:0011663)2.00031497
48Easy fatigability (HP:0003388)1.99947780
49Bladder diverticulum (HP:0000015)1.99486482
50Absent epiphyses (HP:0010577)1.99484146
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99484146
52Progressive sensorineural hearing impairment (HP:0000408)1.99217427
53Abnormality of the thoracic spine (HP:0100711)1.98785399
54Turricephaly (HP:0000262)1.98590272
55Insomnia (HP:0100785)1.98552369
56Germ cell neoplasia (HP:0100728)1.98492366
57Cupped ribs (HP:0000887)1.97747783
58Limited elbow extension (HP:0001377)1.97305823
59Overriding aorta (HP:0002623)1.96874192
60Selective tooth agenesis (HP:0001592)1.96860237
61Thin ribs (HP:0000883)1.96635449
62Hypoplastic ischia (HP:0003175)1.95826798
63Atrophic scars (HP:0001075)1.93278780
64Distal lower limb amyotrophy (HP:0008944)1.92564575
65J-shaped sella turcica (HP:0002680)1.92162765
66Stridor (HP:0010307)1.92037032
67Short 5th finger (HP:0009237)1.91608992
68Thin bony cortex (HP:0002753)1.91153521
69Abnormality of the astrocytes (HP:0100707)1.90371410
70Astrocytoma (HP:0009592)1.90371410
71Increased nuchal translucency (HP:0010880)1.89961674
72Ankyloglossia (HP:0010296)1.89809337
73Epiphyseal dysplasia (HP:0002656)1.89428108
74Neonatal death (HP:0003811)1.89339312
75Bowel diverticulosis (HP:0005222)1.86526631
76Natal tooth (HP:0000695)1.86316027
77Subacute progressive viral hepatitis (HP:0006572)1.86118741
78Metaphyseal cupping (HP:0003021)1.86035019
79Trigonocephaly (HP:0000243)1.85953419
80Long eyelashes (HP:0000527)1.85794652
81Long palpebral fissure (HP:0000637)1.84643566
82Nasal polyposis (HP:0100582)1.84392470
83Dilatation of the ascending aorta (HP:0005111)1.84250576
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.84122807
85Abnormal ossification of hand bones (HP:0005921)1.83789151
86Vitreoretinal degeneration (HP:0000655)1.83644114
87Hyperparathyroidism (HP:0000843)1.83538174
88Radial bowing (HP:0002986)1.83291134
89Abdominal distention (HP:0003270)1.83260264
90Xanthomatosis (HP:0000991)1.83226870
91Mildly elevated creatine phosphokinase (HP:0008180)1.82955640
92Pointed chin (HP:0000307)1.82534967
93Persistence of primary teeth (HP:0006335)1.82271111
94Abnormality of the radial head (HP:0003995)1.81379240
95Delayed epiphyseal ossification (HP:0002663)1.80985016
96Hypercholesterolemia (HP:0003124)1.80748010
97Ankle contracture (HP:0006466)1.80505006
98Abnormal vertebral ossification (HP:0100569)1.79596084
99Short phalanx of the thumb (HP:0009660)1.79471312
100Abnormality of carpal bone ossification (HP:0006257)1.78403102
101Rib fusion (HP:0000902)1.77908586
102Preauricular skin tag (HP:0000384)1.77861234
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76574906
104Neoplasm of the heart (HP:0100544)1.76139885
105Lymphangioma (HP:0100764)1.75867995
106Mitral regurgitation (HP:0001653)1.75253000
107Dislocated radial head (HP:0003083)1.74916698
108Peritonitis (HP:0002586)1.74569183
109Broad phalanges of the hand (HP:0009768)1.74485110
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74265497
111Abnormality of oral frenula (HP:0000190)1.74184282
112Gastrointestinal carcinoma (HP:0002672)1.73655315
113Malignant gastrointestinal tract tumors (HP:0006749)1.73655315
114Patellar dislocation (HP:0002999)1.73310097
115Joint hemorrhage (HP:0005261)1.73028298
116Nasolacrimal duct obstruction (HP:0000579)1.72447380
117Protuberant abdomen (HP:0001538)1.72202499
118Basal cell carcinoma (HP:0002671)1.71941390
119Abnormality of the Achilles tendon (HP:0005109)1.71897899
120Precocious puberty (HP:0000826)1.71306615
121Hyperthyroidism (HP:0000836)1.70515239
122Short 1st metacarpal (HP:0010034)1.70487156
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70487156
124Coxa vara (HP:0002812)1.70129901
125Nuclear cataract (HP:0100018)1.69918338
126Vertebral fusion (HP:0002948)1.68419541
127Deviation of the thumb (HP:0009603)1.67875113
128Premature rupture of membranes (HP:0001788)1.67171534
129Aortic aneurysm (HP:0004942)1.66957499
130Broad palm (HP:0001169)1.66884912
131Cervical subluxation (HP:0003308)1.66825070
132Arnold-Chiari malformation (HP:0002308)1.66643476
133Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65592108
134Focal segmental glomerulosclerosis (HP:0000097)1.65519211
135Abnormality of complement system (HP:0005339)1.64634148
136Septate vagina (HP:0001153)1.64451742
137Acanthosis nigricans (HP:0000956)1.63743061
138Abnormal tarsal ossification (HP:0008369)1.63429651
139Spina bifida occulta (HP:0003298)1.62554791
140Heterotopia (HP:0002282)1.62509228
141Alacrima (HP:0000522)1.62131052
142Urethral obstruction (HP:0000796)1.61374298
143Abnormality of the nasal mucosa (HP:0000433)1.61010318
144Somatic mutation (HP:0001428)1.60677739
145Vertebral arch anomaly (HP:0008438)1.60574903
146Colitis (HP:0002583)1.60091688
147Camptodactyly of toe (HP:0001836)1.59778691
148Ureteral stenosis (HP:0000071)1.59665446
149Fibroma (HP:0010614)1.59570261
150Gastrointestinal inflammation (HP:0004386)1.59461670
151Fragile skin (HP:0001030)1.59125017
152Back pain (HP:0003418)1.58957608
153Missing ribs (HP:0000921)1.58722974
154Blue sclerae (HP:0000592)1.58704804
155Flat acetabular roof (HP:0003180)1.58427128
156Congenital glaucoma (HP:0001087)1.58360889
157Broad finger (HP:0001500)1.58123905
158Abnormality of the nasal septum (HP:0000419)1.58001444
159Midface retrusion (HP:0011800)1.57768952
160Down-sloping shoulders (HP:0200021)1.57753860
161Flat cornea (HP:0007720)1.57639076
162Broad metatarsal (HP:0001783)1.57608912
163Enlarged penis (HP:0000040)1.57072879
164Biconcave vertebral bodies (HP:0004586)1.56877121
165Long toe (HP:0010511)1.56599814
166Achilles tendon contracture (HP:0001771)1.56162039
167Papilloma (HP:0012740)1.55732416
168Verrucae (HP:0200043)1.55732416
169Broad toe (HP:0001837)1.55670705
170Pustule (HP:0200039)1.55641111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.72413535
2TRIB34.22876835
3CDK123.75119001
4EEF2K3.30299250
5ERN13.04864708
6PKN23.01702569
7SMG12.77221443
8MST1R2.24957083
9ICK2.15678396
10IRAK32.14966513
11PTK62.12006653
12RIPK11.94913857
13PDGFRA1.91020852
14SIK11.89742197
15MAP4K11.86973274
16BMX1.68857136
17EPHA21.64491612
18DDR21.58597974
19FGFR41.55148664
20ALK1.50777245
21PRPF4B1.44838658
22MTOR1.40896755
23LRRK21.32252652
24TYRO31.31526468
25EPHB11.31090691
26STK101.27106947
27GRK61.26460126
28TAOK11.25050892
29LATS11.24993385
30SIK21.24750464
31LMTK21.24724991
32CHUK1.23890852
33JAK31.21612375
34BRD41.19832741
35RPS6KB21.18598683
36TTN1.17318562
37EPHA31.15551223
38MAPK151.14598585
39PAK41.13821439
40PTK21.12357728
41MET1.08870072
42NEK21.04870979
43MAP3K71.01381471
44PASK0.97875646
45DYRK1B0.97645208
46EPHB20.96111684
47CDK40.95420115
48HIPK20.94845005
49SCYL20.94308827
50LATS20.93748821
51CDK60.93188472
52PAK20.92283442
53MUSK0.92031280
54ZAP700.90956531
55NME20.86746268
56PDPK10.86118368
57FGFR20.83949473
58FGFR30.83803222
59CSK0.83501071
60RPS6KA40.82321384
61MAP3K60.81131672
62MAP3K80.80829263
63PRKD30.80458951
64CDC42BPA0.79494177
65MAP3K110.78683172
66PDGFRB0.76940812
67TBK10.76843328
68PRKD20.75724607
69STK380.75491542
70FLT30.74499332
71WNK40.72419947
72TYK20.71618271
73MAP2K20.71309701
74CDK70.69440231
75SIK30.68165895
76WNK10.67703399
77CAMK1D0.67661400
78CAMK1G0.67546159
79MAPK110.67342583
80MARK20.66080466
81DMPK0.63685502
82FGFR10.62981643
83RPS6KA10.61522742
84MAP3K90.61419164
85TNK20.58520567
86JAK10.57433782
87BTK0.57036490
88PIM10.55175574
89NME10.55093391
90ERBB20.53884546
91MATK0.53798194
92PRKCI0.52141331
93CAMKK10.51830927
94MAP3K140.51546041
95RET0.51057538
96IKBKB0.50383379
97STK30.49737937
98JAK20.49466093
99TGFBR10.48299784
100CHEK10.47705520
101MAP3K130.46801084
102IRAK20.46745353
103TESK10.45696984
104UHMK10.44768579
105PRKAA20.44515460
106CDK20.43121141
107HCK0.41638821
108PRKAA10.41407328
109ILK0.41180412
110MAPK80.41160490
111INSRR0.40632778
112PRKCH0.39985162
113MAPK10.39664372
114CSF1R0.39557507
115EGFR0.39252938
116MAP3K10.38967076
117PDK10.38863103
118MAPKAPK20.38454556
119GSK3A0.38269575
120CDK90.37620100
121PRKG20.36306613
122CDK80.35543290
123TESK20.34782003
124MAP2K30.34709651
125SGK30.34528208
126AKT20.34020381
127ITK0.33514320
128TAOK20.33246768
129RPS6KA20.32941648
130NTRK10.31555214
131RPS6KA60.31186606
132RPS6KC10.31095848
133RPS6KL10.31095848
134KSR20.31041201
135MAP3K30.28574669
136GSK3B0.28161614

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.65188489
2Chronic myeloid leukemia_Homo sapiens_hsa052202.22630117
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.13289059
4Notch signaling pathway_Homo sapiens_hsa043301.86420479
5Small cell lung cancer_Homo sapiens_hsa052221.76104305
6Acute myeloid leukemia_Homo sapiens_hsa052211.72297823
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.71694587
8Bladder cancer_Homo sapiens_hsa052191.69303563
9Basal cell carcinoma_Homo sapiens_hsa052171.64068189
10mTOR signaling pathway_Homo sapiens_hsa041501.63275251
11MicroRNAs in cancer_Homo sapiens_hsa052061.56752108
12Lysine degradation_Homo sapiens_hsa003101.55808531
13Adherens junction_Homo sapiens_hsa045201.55458494
14Complement and coagulation cascades_Homo sapiens_hsa046101.54830928
15B cell receptor signaling pathway_Homo sapiens_hsa046621.52631123
16Hippo signaling pathway_Homo sapiens_hsa043901.50741080
17Proteoglycans in cancer_Homo sapiens_hsa052051.49037783
18Primary immunodeficiency_Homo sapiens_hsa053401.46821775
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42991554
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40468164
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38417300
22Antigen processing and presentation_Homo sapiens_hsa046121.38142797
23Fructose and mannose metabolism_Homo sapiens_hsa000511.36405578
24Toxoplasmosis_Homo sapiens_hsa051451.34585281
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34169939
26Endometrial cancer_Homo sapiens_hsa052131.34124652
27HTLV-I infection_Homo sapiens_hsa051661.33636934
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.32103372
29Sulfur relay system_Homo sapiens_hsa041221.31418073
30Phenylalanine metabolism_Homo sapiens_hsa003601.30927134
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29921635
32Fat digestion and absorption_Homo sapiens_hsa049751.29680388
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28640924
34Prolactin signaling pathway_Homo sapiens_hsa049171.28461145
35Pancreatic cancer_Homo sapiens_hsa052121.26566600
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.26454899
37Non-small cell lung cancer_Homo sapiens_hsa052231.25117807
38VEGF signaling pathway_Homo sapiens_hsa043701.24599861
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24157118
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23272730
41T cell receptor signaling pathway_Homo sapiens_hsa046601.21869999
42Viral myocarditis_Homo sapiens_hsa054161.20805995
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.19511699
44Fatty acid biosynthesis_Homo sapiens_hsa000611.19198470
45Leishmaniasis_Homo sapiens_hsa051401.18444548
46Thyroid cancer_Homo sapiens_hsa052161.18247594
47Focal adhesion_Homo sapiens_hsa045101.18210667
48Colorectal cancer_Homo sapiens_hsa052101.18005284
49Hedgehog signaling pathway_Homo sapiens_hsa043401.15520469
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15517582
51Hepatitis B_Homo sapiens_hsa051611.14232014
52Bile secretion_Homo sapiens_hsa049761.13856080
53TNF signaling pathway_Homo sapiens_hsa046681.13805269
54Prion diseases_Homo sapiens_hsa050201.13448597
55Insulin resistance_Homo sapiens_hsa049311.13174121
56Osteoclast differentiation_Homo sapiens_hsa043801.11824217
57Apoptosis_Homo sapiens_hsa042101.11430214
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11337146
59Viral carcinogenesis_Homo sapiens_hsa052031.09059579
60Herpes simplex infection_Homo sapiens_hsa051681.07887189
61mRNA surveillance pathway_Homo sapiens_hsa030151.07235019
62Arginine biosynthesis_Homo sapiens_hsa002201.06164129
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.05046946
64Axon guidance_Homo sapiens_hsa043601.04951443
65Galactose metabolism_Homo sapiens_hsa000521.03875859
66Amoebiasis_Homo sapiens_hsa051461.03112099
67Thyroid hormone synthesis_Homo sapiens_hsa049181.01574266
68Vitamin digestion and absorption_Homo sapiens_hsa049771.00542581
69Glioma_Homo sapiens_hsa052140.99089008
70ABC transporters_Homo sapiens_hsa020100.98529960
71Choline metabolism in cancer_Homo sapiens_hsa052310.98389259
72Shigellosis_Homo sapiens_hsa051310.97478655
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97455815
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95662038
75Prostate cancer_Homo sapiens_hsa052150.94949266
76Renal cell carcinoma_Homo sapiens_hsa052110.93919241
77Measles_Homo sapiens_hsa051620.93757295
78One carbon pool by folate_Homo sapiens_hsa006700.93163839
79Type II diabetes mellitus_Homo sapiens_hsa049300.92532970
80Pathways in cancer_Homo sapiens_hsa052000.92272101
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92157508
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91945205
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90215321
84Glucagon signaling pathway_Homo sapiens_hsa049220.90016262
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89823197
86PPAR signaling pathway_Homo sapiens_hsa033200.89646158
87Inositol phosphate metabolism_Homo sapiens_hsa005620.89034511
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.88734796
89Influenza A_Homo sapiens_hsa051640.88473377
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87507338
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.86011558
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85065691
93GnRH signaling pathway_Homo sapiens_hsa049120.83949907
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81909625
95Estrogen signaling pathway_Homo sapiens_hsa049150.80090873
96TGF-beta signaling pathway_Homo sapiens_hsa043500.79808991
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.78581487
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78396626
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77963455
100ECM-receptor interaction_Homo sapiens_hsa045120.77909067
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77515451
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.77469837
103Legionellosis_Homo sapiens_hsa051340.76940499
104p53 signaling pathway_Homo sapiens_hsa041150.76462708
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75913666
106Spliceosome_Homo sapiens_hsa030400.75150510
107Wnt signaling pathway_Homo sapiens_hsa043100.74034840
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73082504
109Tight junction_Homo sapiens_hsa045300.72593127
110ErbB signaling pathway_Homo sapiens_hsa040120.71489086
111Chemokine signaling pathway_Homo sapiens_hsa040620.71133649
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70596482
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70394236
114Histidine metabolism_Homo sapiens_hsa003400.70136604
115HIF-1 signaling pathway_Homo sapiens_hsa040660.69946531
116Insulin signaling pathway_Homo sapiens_hsa049100.68684182
117RNA transport_Homo sapiens_hsa030130.68039479
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.67768264
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67251391
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65897401
121Hepatitis C_Homo sapiens_hsa051600.65551910
122Dorso-ventral axis formation_Homo sapiens_hsa043200.64648782
123AMPK signaling pathway_Homo sapiens_hsa041520.63881277
124Epstein-Barr virus infection_Homo sapiens_hsa051690.63875903
125Biosynthesis of amino acids_Homo sapiens_hsa012300.63524265
126FoxO signaling pathway_Homo sapiens_hsa040680.63417061
127MAPK signaling pathway_Homo sapiens_hsa040100.62703183
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62583250
129Protein digestion and absorption_Homo sapiens_hsa049740.62509124
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62307920
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62069211
132Vibrio cholerae infection_Homo sapiens_hsa051100.61119275
133N-Glycan biosynthesis_Homo sapiens_hsa005100.60774330
134Glycerolipid metabolism_Homo sapiens_hsa005610.59744449
135Arginine and proline metabolism_Homo sapiens_hsa003300.59194914
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58418932
137Pentose phosphate pathway_Homo sapiens_hsa000300.57592950
138Cocaine addiction_Homo sapiens_hsa050300.57405410
139Rap1 signaling pathway_Homo sapiens_hsa040150.57219699
140Tyrosine metabolism_Homo sapiens_hsa003500.57010649
141Cell cycle_Homo sapiens_hsa041100.56683000
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55926440
143Melanogenesis_Homo sapiens_hsa049160.53857337
144Platelet activation_Homo sapiens_hsa046110.53559878
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53375119
146Endocytosis_Homo sapiens_hsa041440.51083051
147Lysosome_Homo sapiens_hsa041420.50497661

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