FOXR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.27787637
2transcription from mitochondrial promoter (GO:0006390)5.63368840
3meiosis I (GO:0007127)5.46936387
4mitotic metaphase plate congression (GO:0007080)5.26724086
5regulation of acrosome reaction (GO:0060046)5.22346148
6chaperone-mediated protein transport (GO:0072321)4.99021080
7regulation of DNA methylation (GO:0044030)4.94879357
8multicellular organism reproduction (GO:0032504)4.76088600
9positive regulation of protein homooligomerization (GO:0032464)4.64088307
10autophagic vacuole assembly (GO:0000045)4.50048024
11ribosomal small subunit biogenesis (GO:0042274)4.44211089
12DNA replication checkpoint (GO:0000076)4.42438874
13purine nucleobase biosynthetic process (GO:0009113)4.40721845
14regulation of double-strand break repair via homologous recombination (GO:0010569)4.37430878
15protein K6-linked ubiquitination (GO:0085020)4.33929423
16meiotic cell cycle (GO:0051321)4.31159634
17metaphase plate congression (GO:0051310)4.29085626
18kinetochore assembly (GO:0051382)4.27529292
19mitotic chromosome condensation (GO:0007076)4.08754824
20regulation of nuclear cell cycle DNA replication (GO:0033262)4.05437202
21regulation of G0 to G1 transition (GO:0070316)4.04419440
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.03032696
23regulation of female gonad development (GO:2000194)4.02753948
24CENP-A containing nucleosome assembly (GO:0034080)4.00697446
25male meiosis (GO:0007140)3.98700797
26establishment of chromosome localization (GO:0051303)3.89166106
27very-low-density lipoprotein particle assembly (GO:0034379)3.88958210
28kinetochore organization (GO:0051383)3.82903149
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.79720955
30ribosome biogenesis (GO:0042254)3.79009672
31DNA deamination (GO:0045006)3.78647994
32chromatin remodeling at centromere (GO:0031055)3.77685224
33meiotic chromosome segregation (GO:0045132)3.77147218
34replication fork processing (GO:0031297)3.76444917
35rRNA modification (GO:0000154)3.71972682
367-methylguanosine mRNA capping (GO:0006370)3.68764064
37nucleobase biosynthetic process (GO:0046112)3.67354148
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.65462534
39termination of RNA polymerase III transcription (GO:0006386)3.65462534
407-methylguanosine RNA capping (GO:0009452)3.65098397
41RNA capping (GO:0036260)3.65098397
42maturation of 5.8S rRNA (GO:0000460)3.62740904
43meiotic nuclear division (GO:0007126)3.62534591
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56298471
45DNA synthesis involved in DNA repair (GO:0000731)3.56137679
46proteasome assembly (GO:0043248)3.54238178
47termination of RNA polymerase I transcription (GO:0006363)3.54086405
48microtubule depolymerization (GO:0007019)3.52750206
49ventricular cardiac muscle cell development (GO:0055015)3.46805990
50DNA replication-independent nucleosome organization (GO:0034724)3.46186366
51DNA replication-independent nucleosome assembly (GO:0006336)3.46186366
52binding of sperm to zona pellucida (GO:0007339)3.44114164
53transcription from RNA polymerase I promoter (GO:0006360)3.43245894
54DNA replication initiation (GO:0006270)3.42562872
55reproduction (GO:0000003)3.42135157
56negative regulation of telomere maintenance (GO:0032205)3.38175617
57histone exchange (GO:0043486)3.38063969
58spindle checkpoint (GO:0031577)3.36633387
59regulation of cytokine production involved in inflammatory response (GO:1900015)3.35532531
60positive regulation of uterine smooth muscle contraction (GO:0070474)3.34934157
61maturation of SSU-rRNA (GO:0030490)3.32273295
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.29963460
63meiotic cell cycle process (GO:1903046)3.29430275
64regulation of transcription from RNA polymerase I promoter (GO:0006356)3.28533448
65protein kinase C signaling (GO:0070528)3.27166833
66transcription elongation from RNA polymerase II promoter (GO:0006368)3.27093891
67negative regulation of reproductive process (GO:2000242)3.27007998
68synapsis (GO:0007129)3.23576109
69ribonucleoprotein complex biogenesis (GO:0022613)3.19405623
70hyperosmotic salinity response (GO:0042538)3.18556600
71mitochondrial RNA metabolic process (GO:0000959)3.18334481
72ribosome assembly (GO:0042255)3.15758770
73skeletal muscle tissue regeneration (GO:0043403)3.15530512
74piRNA metabolic process (GO:0034587)3.15175606
75rRNA processing (GO:0006364)3.12953393
76transcription initiation from RNA polymerase I promoter (GO:0006361)3.12448975
77regulation of spindle organization (GO:0090224)3.11603842
78positive regulation of humoral immune response (GO:0002922)3.11269893
79synaptonemal complex assembly (GO:0007130)3.10917986
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10641464
81telomere maintenance via recombination (GO:0000722)3.09706956
82rRNA methylation (GO:0031167)3.06982090
83regulation of telomere maintenance via telomerase (GO:0032210)3.06642831
84DNA-templated transcription, elongation (GO:0006354)3.05430476
85DNA double-strand break processing (GO:0000729)3.05366329
86chromosome organization involved in meiosis (GO:0070192)3.05290620
87viral transcription (GO:0019083)3.04616883
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.03142353
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03142353
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03142353
91negative regulation of sister chromatid segregation (GO:0033046)3.03142353
92translational termination (GO:0006415)3.03126005
93reciprocal DNA recombination (GO:0035825)3.02738053
94reciprocal meiotic recombination (GO:0007131)3.02738053
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01914622
96negative regulation of chromosome segregation (GO:0051985)3.00872016
97rRNA metabolic process (GO:0016072)3.00536323
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)26.0680790
99regulation of retinoic acid receptor signaling pathway (GO:0048385)21.9687682
100mitotic spindle checkpoint (GO:0071174)2.99732949
101oocyte development (GO:0048599)2.99651562
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99610798
103telomere maintenance via semi-conservative replication (GO:0032201)2.99462173
104activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.99331828
105regulation of mitotic spindle checkpoint (GO:1903504)2.99236073
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99236073
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99213595
108attachment of spindle microtubules to kinetochore (GO:0008608)2.98704480
109spindle assembly checkpoint (GO:0071173)2.96238933
110ribosomal small subunit assembly (GO:0000028)2.95948652
111transcription-coupled nucleotide-excision repair (GO:0006283)2.95204654
112monoubiquitinated protein deubiquitination (GO:0035520)2.94583258
113negative regulation of DNA-templated transcription, elongation (GO:0032785)2.94098558
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.94098558
115mitotic spindle assembly checkpoint (GO:0007094)2.93275408
116response to UV-C (GO:0010225)2.91720218
117DNA-dependent DNA replication (GO:0006261)2.89691248
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88171374
119regulation of sister chromatid segregation (GO:0033045)2.86789255
120regulation of mitotic sister chromatid separation (GO:0010965)2.86789255
121regulation of mitotic sister chromatid segregation (GO:0033047)2.86789255
122regulation of mitotic spindle organization (GO:0060236)2.86466068
123mitotic sister chromatid segregation (GO:0000070)2.85317440
124telomere maintenance via telomere lengthening (GO:0010833)2.85082407
125regulation of RIG-I signaling pathway (GO:0039535)2.84807592
126regulation of chromosome segregation (GO:0051983)2.84271853
127synaptonemal complex organization (GO:0070193)2.83972498
128mismatch repair (GO:0006298)2.83393266
129negative regulation of mast cell activation (GO:0033004)2.80684746
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.79866059
131negative regulation of meiosis (GO:0045835)2.78756013
132regulation of oxidative phosphorylation (GO:0002082)2.78157648
133ribosomal large subunit biogenesis (GO:0042273)2.77779704
134gene silencing by RNA (GO:0031047)2.77579306
135chromosome segregation (GO:0007059)2.77483829
136regulation of female receptivity (GO:0045924)2.77407458
137positive regulation of chromosome segregation (GO:0051984)2.76713156
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76243501
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76243501
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.76243501
141N-terminal protein amino acid acetylation (GO:0006474)2.76046485
142protein localization to kinetochore (GO:0034501)2.75594440
143translational initiation (GO:0006413)2.75434114
144mitotic recombination (GO:0006312)2.75385262
145oocyte maturation (GO:0001556)2.74878028
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73561493
147regulation of mitochondrial translation (GO:0070129)2.73193965
148DNA methylation involved in gamete generation (GO:0043046)2.72724075
149poly(A)+ mRNA export from nucleus (GO:0016973)2.72661827
150transcription from RNA polymerase III promoter (GO:0006383)2.71700831
151sperm-egg recognition (GO:0035036)2.71225371
152protein localization to chromosome, centromeric region (GO:0071459)2.69982633
153mitotic G2/M transition checkpoint (GO:0044818)2.69257977
154regulation of helicase activity (GO:0051095)2.68510741
155replicative senescence (GO:0090399)2.68361262
156regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.67786132
157aggressive behavior (GO:0002118)2.67721306
158DNA strand elongation involved in DNA replication (GO:0006271)2.67628413
159resolution of meiotic recombination intermediates (GO:0000712)2.67139013
160DNA strand elongation (GO:0022616)2.66718423
161regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66697615
162regulation of meiosis I (GO:0060631)2.66407698
163translational elongation (GO:0006414)2.65127425
164protein targeting to mitochondrion (GO:0006626)2.62843572
165regulation of RNA export from nucleus (GO:0046831)2.62117157
166intestinal cholesterol absorption (GO:0030299)2.59905786
167pseudouridine synthesis (GO:0001522)2.59332645
168drinking behavior (GO:0042756)2.58935439
169fertilization (GO:0009566)2.57779108
170single fertilization (GO:0007338)2.56169150
171chaperone mediated protein folding requiring cofactor (GO:0051085)2.53840671
172regulation of uterine smooth muscle contraction (GO:0070472)2.53745296
173positive regulation of cAMP-mediated signaling (GO:0043950)2.50251099
174negative regulation of RNA splicing (GO:0033119)2.49304943
175negative regulation of epidermal cell differentiation (GO:0045605)2.47759093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64645212
2EZH2_22144423_ChIP-Seq_EOC_Human4.13340527
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90501013
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84729102
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.42945394
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32703749
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29476659
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22684394
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.10366828
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.10366828
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.10366828
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.05590954
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81250415
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72865418
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.67987552
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.52018857
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.46965510
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43472542
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34365292
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.33758005
21VDR_23849224_ChIP-Seq_CD4+_Human2.30175057
22KAP1_22055183_ChIP-Seq_ESCs_Mouse2.27993758
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26850044
24ZNF274_21170338_ChIP-Seq_K562_Hela2.25656130
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23946974
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20013707
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12696716
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.09319269
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05284306
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.00403985
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99962620
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.98913684
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.97645465
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97487851
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95418873
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95246805
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93901277
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93532317
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.86661650
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84993662
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84353882
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.83962635
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82266838
44FOXP3_21729870_ChIP-Seq_TREG_Human1.78063591
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77389790
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.75611444
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75063216
48ELK1_19687146_ChIP-ChIP_HELA_Human1.74841259
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68152227
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67802788
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61859370
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61806421
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60882899
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59705746
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59469770
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52376718
57ZNF263_19887448_ChIP-Seq_K562_Human1.52076886
58DCP1A_22483619_ChIP-Seq_HELA_Human1.52054414
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51875978
60GABP_19822575_ChIP-Seq_HepG2_Human1.51558403
61AR_21909140_ChIP-Seq_LNCAP_Human1.51039158
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40461953
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37431981
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.37177412
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34830111
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30670918
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29099349
68ETV1_20927104_ChIP-Seq_GIST48_Human1.27750406
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27214758
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.26367543
71XRN2_22483619_ChIP-Seq_HELA_Human1.25253522
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24295833
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23975968
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22705336
75RBPJ_21746931_ChIP-Seq_IB4_Human1.21805238
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20684215
77LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18492923
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17730864
79PHF8_20622853_ChIP-Seq_HELA_Human1.15652643
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14511135
81TTF2_22483619_ChIP-Seq_HELA_Human1.14405237
82TP53_22573176_ChIP-Seq_HFKS_Human1.08679234
83NFYB_21822215_ChIP-Seq_K562_Human1.08335291
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.06658364
85CIITA_25753668_ChIP-Seq_RAJI_Human1.05962227
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04773986
87KDM5A_27292631_Chip-Seq_BREAST_Human1.02830640
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02802195
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02534467
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02496002
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02261661
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01167156
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98810391
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.98129853
95SPI1_23547873_ChIP-Seq_NB4_Human0.97934303
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96845292
97MYC_18940864_ChIP-ChIP_HL60_Human0.96546954
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96295100
99CTCF_20526341_ChIP-Seq_ESCs_Human0.95482618
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95330940
101ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95325287
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93312385
103TBL1_22424771_ChIP-Seq_293T_Human0.92410240
104STAT3_18555785_Chip-Seq_ESCs_Mouse0.90877841
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89883865
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89519884
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87881520
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87661669
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.87420686
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87208059
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86977710
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.86827559
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86657242
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85482430
115NMYC_18555785_Chip-Seq_ESCs_Mouse0.84536325
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.83170734
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83029397
118CTCF_21964334_Chip-Seq_Bcells_Human0.83024020
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.81596693
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81580478
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81154692
122HNFA_21074721_ChIP-Seq_CACO-2_Human0.79955913
123IRF1_19129219_ChIP-ChIP_H3396_Human0.79592608
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78483758
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76607106
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76048840
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.74546128
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.72852501
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.71585842
130RUNX1_27457419_Chip-Seq_LIVER_Mouse0.71030296
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70692032
132EWS_26573619_Chip-Seq_HEK293_Human0.70603499
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70437396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous6.02965593
2MP0003693_abnormal_embryo_hatching4.82663651
3MP0006292_abnormal_olfactory_placode4.08242615
4MP0008057_abnormal_DNA_replication3.96196012
5MP0003111_abnormal_nucleus_morphology3.87548698
6MP0008058_abnormal_DNA_repair3.78995379
7MP0009379_abnormal_foot_pigmentation3.78442200
8MP0010094_abnormal_chromosome_stability3.54194152
9MP0008007_abnormal_cellular_replicative3.27652440
10MP0003718_maternal_effect3.16116713
11MP0003077_abnormal_cell_cycle3.12280387
12MP0008877_abnormal_DNA_methylation2.46715082
13MP0003786_premature_aging2.45179390
14MP0004957_abnormal_blastocyst_morpholog2.44065293
15MP0001188_hyperpigmentation2.31665202
16MP0003941_abnormal_skin_development2.25626829
17MP0008260_abnormal_autophagy2.19808026
18MP0002132_abnormal_respiratory_system2.01239852
19MP0000015_abnormal_ear_pigmentation2.00804999
20MP0002396_abnormal_hematopoietic_system1.94538604
21MP0000566_synostosis1.89459492
22MP0002102_abnormal_ear_morphology1.87361159
23MP0002127_abnormal_cardiovascular_syste1.83274137
24MP0009840_abnormal_foam_cell1.80184101
25MP0003136_yellow_coat_color1.79001647
26MP0001119_abnormal_female_reproductive1.75051868
27MP0001835_abnormal_antigen_presentation1.74193127
28MP0008932_abnormal_embryonic_tissue1.67002914
29MP0008995_early_reproductive_senescence1.62338869
30MP0002210_abnormal_sex_determination1.57272924
31MP0009333_abnormal_splenocyte_physiolog1.56524309
32MP0002277_abnormal_respiratory_mucosa1.55536302
33MP0002638_abnormal_pupillary_reflex1.54768757
34MP0010030_abnormal_orbit_morphology1.44601332
35MP0005410_abnormal_fertilization1.43692067
36MP0005451_abnormal_body_composition1.43555433
37MP0002161_abnormal_fertility/fecundity1.40228623
38MP0009697_abnormal_copulation1.39158986
39MP0005671_abnormal_response_to1.37693427
40MP0004782_abnormal_surfactant_physiolog1.33436017
41MP0005408_hypopigmentation1.32593438
42MP0002163_abnormal_gland_morphology1.28489123
43MP0001697_abnormal_embryo_size1.28159298
44MP0010307_abnormal_tumor_latency1.27365143
45MP0001929_abnormal_gametogenesis1.26773407
46MP0003984_embryonic_growth_retardation1.24732951
47MP0003763_abnormal_thymus_physiology1.23595762
48MP0005171_absent_coat_pigmentation1.22740638
49MP0000653_abnormal_sex_gland1.22640536
50MP0006036_abnormal_mitochondrial_physio1.22389260
51MP0010386_abnormal_urinary_bladder1.22367234
52MP0000490_abnormal_crypts_of1.20925393
53MP0005389_reproductive_system_phenotype1.20061559
54MP0002088_abnormal_embryonic_growth/wei1.18655378
55MP0003787_abnormal_imprinting1.18487228
56MP0005395_other_phenotype1.18392668
57MP0000350_abnormal_cell_proliferation1.15668786
58MP0002148_abnormal_hypersensitivity_rea1.14458985
59MP0001145_abnormal_male_reproductive1.13635486
60MP0005397_hematopoietic_system_phenotyp1.09385461
61MP0001545_abnormal_hematopoietic_system1.09385461
62MP0005647_abnormal_sex_gland1.08321102
63MP0002160_abnormal_reproductive_system1.07926434
64MP0009785_altered_susceptibility_to1.07239122
65MP0003315_abnormal_perineum_morphology1.06746970
66MP0000372_irregular_coat_pigmentation1.03677184
67MP0003890_abnormal_embryonic-extraembry1.02188983
68MP0008789_abnormal_olfactory_epithelium1.02156666
69MP0006035_abnormal_mitochondrial_morpho1.01194654
70MP0001666_abnormal_nutrient_absorption1.00080820
71MP0001919_abnormal_reproductive_system0.99475936
72MP0003699_abnormal_female_reproductive0.99168626
73MP0010368_abnormal_lymphatic_system0.98902888
74MP0005377_hearing/vestibular/ear_phenot0.98494973
75MP0003878_abnormal_ear_physiology0.98494973
76MP0002095_abnormal_skin_pigmentation0.97608060
77MP0000358_abnormal_cell_content/0.97601150
78MP0002085_abnormal_embryonic_tissue0.97508929
79MP0005075_abnormal_melanosome_morpholog0.96693415
80MP0002876_abnormal_thyroid_physiology0.96601232
81MP0003186_abnormal_redox_activity0.95224937
82MP0000313_abnormal_cell_death0.95203123
83MP0002080_prenatal_lethality0.94686011
84MP0001186_pigmentation_phenotype0.93981122
85MP0006276_abnormal_autonomic_nervous0.93760353
86MP0000750_abnormal_muscle_regeneration0.91411740
87MP0002019_abnormal_tumor_incidence0.90789015
88MP0004808_abnormal_hematopoietic_stem0.89674819
89MP0004019_abnormal_vitamin_homeostasis0.88895050
90MP0002084_abnormal_developmental_patter0.88565707
91MP0003123_paternal_imprinting0.88393052
92MP0005646_abnormal_pituitary_gland0.88190792
93MP0005380_embryogenesis_phenotype0.88135632
94MP0001672_abnormal_embryogenesis/_devel0.88135632
95MP0005360_urolithiasis0.86071694
96MP0004147_increased_porphyrin_level0.85889535
97MP0002452_abnormal_antigen_presenting0.85791980
98MP0003828_pulmonary_edema0.84956870
99MP0002419_abnormal_innate_immunity0.84794987
100MP0002398_abnormal_bone_marrow0.84191008
101MP0001881_abnormal_mammary_gland0.83977842
102MP0005310_abnormal_salivary_gland0.82838545
103MP0000462_abnormal_digestive_system0.80190778
104MP0003646_muscle_fatigue0.79494369
105MP0001346_abnormal_lacrimal_gland0.79192088
106MP0001819_abnormal_immune_cell0.78747936
107MP0003119_abnormal_digestive_system0.78535118
108MP0002796_impaired_skin_barrier0.78465672
109MP0002938_white_spotting0.78267461
110MP0002420_abnormal_adaptive_immunity0.77090449
111MP0001529_abnormal_vocalization0.76312983
112MP0001730_embryonic_growth_arrest0.75974168
113MP0002723_abnormal_immune_serum0.75420940
114MP0003938_abnormal_ear_development0.75099719
115MP0001800_abnormal_humoral_immune0.73966287
116MP0000689_abnormal_spleen_morphology0.72573842
117MP0005025_abnormal_response_to0.71125995
118MP0005000_abnormal_immune_tolerance0.71059641
119MP0000716_abnormal_immune_system0.70450844
120MP0003879_abnormal_hair_cell0.69967689
121MP0001986_abnormal_taste_sensitivity0.69756157
122MP0001293_anophthalmia0.69698184
123MP0002138_abnormal_hepatobiliary_system0.68662641
124MP0003121_genomic_imprinting0.68535977
125MP0002086_abnormal_extraembryonic_tissu0.68320802
126MP0003698_abnormal_male_reproductive0.67715751
127MP0004381_abnormal_hair_follicle0.67458248
128MP0001764_abnormal_homeostasis0.67285925
129MP0003937_abnormal_limbs/digits/tail_de0.67184067
130MP0005394_taste/olfaction_phenotype0.66841236
131MP0005499_abnormal_olfactory_system0.66841236
132MP0000678_abnormal_parathyroid_gland0.66168053
133MP0003950_abnormal_plasma_membrane0.66073162
134MP0000049_abnormal_middle_ear0.65947293
135MP0005501_abnormal_skin_physiology0.65931393
136MP0002429_abnormal_blood_cell0.65624623
137MP0005174_abnormal_tail_pigmentation0.64692199
138MP0003943_abnormal_hepatobiliary_system0.62056125
139MP0005085_abnormal_gallbladder_physiolo0.61891554
140MP0003936_abnormal_reproductive_system0.60412308
141MP0002139_abnormal_hepatobiliary_system0.59984202
142MP0003567_abnormal_fetal_cardiomyocyte0.57605354
143MP0002233_abnormal_nose_morphology0.56571762
144MP0004215_abnormal_myocardial_fiber0.56095941
145MP0002873_normal_phenotype0.55832602
146MP0002169_no_abnormal_phenotype0.55698001
147MP0000631_abnormal_neuroendocrine_gland0.54558908
148MP0002735_abnormal_chemical_nociception0.53768016
149MP0004233_abnormal_muscle_weight0.51906024
150MP0001502_abnormal_circadian_rhythm0.48439081
151MP0001286_abnormal_eye_development0.46613435

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.49314763
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.81997552
3Chromsome breakage (HP:0040012)5.52575568
4Birth length less than 3rd percentile (HP:0003561)5.43987982
5Microvesicular hepatic steatosis (HP:0001414)4.28706577
6Premature ovarian failure (HP:0008209)4.16154288
7Breast hypoplasia (HP:0003187)3.92060342
8Meckel diverticulum (HP:0002245)3.84697802
9Patent foramen ovale (HP:0001655)3.83599459
10Hypercortisolism (HP:0001578)3.72561496
11Abnormality of the ileum (HP:0001549)3.68250547
12Abnormality of the preputium (HP:0100587)3.65532498
13Patellar aplasia (HP:0006443)3.64493900
14Congenital malformation of the right heart (HP:0011723)3.62655494
15Double outlet right ventricle (HP:0001719)3.62655494
16Aplasia/hypoplasia of the uterus (HP:0008684)3.51572890
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.50407311
18Short tibia (HP:0005736)3.49338883
19Abnormality of chromosome stability (HP:0003220)3.46914337
20Aplasia/Hypoplasia of the patella (HP:0006498)3.40043518
21Progressive muscle weakness (HP:0003323)3.33731348
22Infertility (HP:0000789)3.33509676
23Prostate neoplasm (HP:0100787)3.32764750
24Abnormal pancreas size (HP:0012094)3.21854443
25Abnormal spermatogenesis (HP:0008669)3.19912485
26Osteomalacia (HP:0002749)3.16123076
27Abnormality of the fetal cardiovascular system (HP:0010948)3.15936483
28Abnormal umbilical cord blood vessels (HP:0011403)3.15936483
29Single umbilical artery (HP:0001195)3.15936483
30Azoospermia (HP:0000027)3.10313167
31Sensory axonal neuropathy (HP:0003390)3.09020919
32Aplasia/Hypoplasia of the tibia (HP:0005772)3.05114925
33Reticulocytopenia (HP:0001896)3.02940503
34Clubbing of toes (HP:0100760)2.98502010
35Hypoplasia of the uterus (HP:0000013)2.95513162
36Abnormality of the aortic arch (HP:0012303)2.94459590
37Malnutrition (HP:0004395)2.84960374
38Impulsivity (HP:0100710)2.83742193
39Pancreatic fibrosis (HP:0100732)2.80149919
40Carpal bone hypoplasia (HP:0001498)2.79699708
41Capillary hemangiomas (HP:0005306)2.78473783
42Bone marrow hypocellularity (HP:0005528)2.74225581
43Multiple enchondromatosis (HP:0005701)2.72375809
44Ectopic kidney (HP:0000086)2.70008090
45Duodenal stenosis (HP:0100867)2.69729105
46Small intestinal stenosis (HP:0012848)2.69729105
47Fused cervical vertebrae (HP:0002949)2.69169636
48Pancreatic cysts (HP:0001737)2.60228820
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59958771
50Type 2 muscle fiber atrophy (HP:0003554)2.58963582
51Myelodysplasia (HP:0002863)2.58215610
52Microretrognathia (HP:0000308)2.57106181
53Dysphonia (HP:0001618)2.54478392
54Stenosis of the external auditory canal (HP:0000402)2.53406201
55Periauricular skin pits (HP:0100277)2.52208151
56Preauricular pit (HP:0004467)2.52208151
57Absent septum pellucidum (HP:0001331)2.49477236
58Type I transferrin isoform profile (HP:0003642)2.49323586
59Anhidrosis (HP:0000970)2.48173877
60Ragged-red muscle fibers (HP:0003200)2.47498511
61Stomach cancer (HP:0012126)2.45516485
62Ileus (HP:0002595)2.44493705
63Abnormality of the labia minora (HP:0012880)2.44263656
64Rough bone trabeculation (HP:0100670)2.42957366
65Abnormality of the phalanges of the hallux (HP:0010057)2.42834810
66Myopathic facies (HP:0002058)2.40401160
67Abnormality of cells of the erythroid lineage (HP:0012130)2.39971609
68Duplicated collecting system (HP:0000081)2.39585740
69Abnormality of the prostate (HP:0008775)2.39433646
70Hypophosphatemic rickets (HP:0004912)2.38963693
71Testicular atrophy (HP:0000029)2.37064366
72Abnormality of the renal collecting system (HP:0004742)2.34002698
73Breast aplasia (HP:0100783)2.29735404
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28826443
75Optic neuritis (HP:0100653)2.27470059
76Retrobulbar optic neuritis (HP:0100654)2.27470059
77Aplastic anemia (HP:0001915)2.26277903
78Midline defect of the nose (HP:0004122)2.25193521
79Reduced antithrombin III activity (HP:0001976)2.24632125
80True hermaphroditism (HP:0010459)2.23726583
81Abdominal situs inversus (HP:0003363)2.23555759
82Abnormality of abdominal situs (HP:0011620)2.23555759
83Abnormality of the anterior horn cell (HP:0006802)2.22382254
84Degeneration of anterior horn cells (HP:0002398)2.22382254
85Aplasia/Hypoplasia of the fovea (HP:0008060)2.17368479
86Hypoplasia of the fovea (HP:0007750)2.17368479
87Hypoglycemic seizures (HP:0002173)2.15157750
88Anterior segment dysgenesis (HP:0007700)2.15012653
89Aplasia/Hypoplasia of the breasts (HP:0010311)2.14280195
90Abnormal number of erythroid precursors (HP:0012131)2.13643679
91Oral leukoplakia (HP:0002745)2.12816073
92Sloping forehead (HP:0000340)2.12641320
93Progressive external ophthalmoplegia (HP:0000590)2.12615828
94Hyperglycemia (HP:0003074)2.12469619
95Muscle fiber atrophy (HP:0100295)2.12102391
96Supernumerary spleens (HP:0009799)2.11067725
97Abnormality of male internal genitalia (HP:0000022)2.10759539
98Abnormality of the carotid arteries (HP:0005344)2.10395368
99Absent radius (HP:0003974)2.10181620
100Increased serum lactate (HP:0002151)2.10060294
101Abnormality of DNA repair (HP:0003254)2.09822541
102Hypoplasia of the radius (HP:0002984)2.07563148
103Cerebral hypomyelination (HP:0006808)2.07333872
104Adrenal hypoplasia (HP:0000835)2.06412845
105Abnormality of the duodenum (HP:0002246)2.04851962
106Septo-optic dysplasia (HP:0100842)2.04363893
107Posterior subcapsular cataract (HP:0007787)2.04131664
108Abnormal trabecular bone morphology (HP:0100671)2.02697846
109Premature graying of hair (HP:0002216)2.02414344
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01696475
111Prolonged neonatal jaundice (HP:0006579)2.01441677
112Recurrent abscess formation (HP:0002722)2.00640858
113Tracheoesophageal fistula (HP:0002575)1.97608967
114Absent forearm bone (HP:0003953)1.96303700
115Aplasia involving forearm bones (HP:0009822)1.96303700
116Skin pits (HP:0100276)1.96267322
117Constricted visual fields (HP:0001133)1.96227177
118Glossoptosis (HP:0000162)1.95717740
119Abnormality of the umbilical cord (HP:0010881)1.95702665
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94369479
121Abnormality of urine glucose concentration (HP:0011016)1.94211003
122Glycosuria (HP:0003076)1.94211003
123Poor speech (HP:0002465)1.93144056
124Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92182892
125Median cleft lip (HP:0000161)1.92006416
126Triphalangeal thumb (HP:0001199)1.91399221
127Cleft eyelid (HP:0000625)1.89740737
128Pili torti (HP:0003777)1.88922846
129Abnormal hair whorl (HP:0010721)1.88526488
130Adrenal overactivity (HP:0002717)1.88424185
131Flat capital femoral epiphysis (HP:0003370)1.87776699
132Acute myeloid leukemia (HP:0004808)1.85389935
133Tubulointerstitial nephritis (HP:0001970)1.84993677
134Abnormality of magnesium homeostasis (HP:0004921)1.84489388
135Trismus (HP:0000211)1.84300574
136Horseshoe kidney (HP:0000085)1.80206845
137Renal cortical cysts (HP:0000803)1.77782072
138Hypergonadotropic hypogonadism (HP:0000815)1.77493943
139Absent thumb (HP:0009777)1.74916579
140Short thumb (HP:0009778)1.74897959
141Hyperalaninemia (HP:0003348)1.74870356
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74870356
143Abnormality of alanine metabolism (HP:0010916)1.74870356
144Papillary thyroid carcinoma (HP:0002895)1.74694565
145Ureteral duplication (HP:0000073)1.74648405
146Facial cleft (HP:0002006)1.74232654
147Secondary amenorrhea (HP:0000869)1.73909314
148Obstructive lung disease (HP:0006536)1.72736391
149Chronic obstructive pulmonary disease (HP:0006510)1.72736391
150Orchitis (HP:0100796)1.72127388
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71961980
152Abnormal protein N-linked glycosylation (HP:0012347)1.71961980
153Abnormal protein glycosylation (HP:0012346)1.71961980
154Abnormal glycosylation (HP:0012345)1.71961980
155IgG deficiency (HP:0004315)1.71209927
156Oligohydramnios (HP:0001562)1.68644612
157Abnormal lung lobation (HP:0002101)1.66510633
158Pulmonary fibrosis (HP:0002206)1.65971027
159Nephroblastoma (Wilms tumor) (HP:0002667)1.65953689
160Abnormality of the fovea (HP:0000493)1.65378245
161Abnormality of the septum pellucidum (HP:0007375)1.64560991
162Homocystinuria (HP:0002156)1.64143880
163Abnormality of homocysteine metabolism (HP:0010919)1.64143880
164Recurrent bacterial skin infections (HP:0005406)1.62293761
165Agnosia (HP:0010524)1.62232704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK43.83361899
2CDK193.73933579
3TESK23.53506673
4ZAK3.21304182
5IRAK33.08792288
6BUB13.08023469
7SRPK12.96207851
8STK38L2.44982843
9PDK22.43256632
10EIF2AK12.42302465
11STK162.29294136
12AKT32.29189469
13WEE12.24645185
14IRAK42.20356648
15TTK2.02383622
16TRIM281.99776363
17ACVR1B1.92253684
18PINK11.91867011
19BRSK21.88693663
20MKNK21.78185061
21EIF2AK31.77252590
22MAP3K91.76803853
23TXK1.76372785
24EIF2AK21.70622683
25PLK31.70104953
26BMX1.68851533
27VRK11.67013181
28PLK11.63755036
29CDC71.62279734
30CDK81.58029469
31NEK21.50638513
32BMPR1B1.41245546
33EPHA21.40168273
34BMPR21.39742777
35SGK21.39298268
36TSSK61.38607703
37MAP3K141.36881952
38NLK1.33352324
39CHEK21.32282095
40STK241.30833303
41BRAF1.29670284
42DYRK21.28350090
43ATR1.24664998
44MKNK11.23833931
45LATS21.23348688
46STK31.14377806
47PAK11.12502149
48AURKB1.12447042
49BRSK11.11228533
50ARAF1.10248164
51CDK31.09660123
52NME21.09444373
53MELK1.06676114
54PKN11.05964213
55CASK1.04899454
56CDK71.03849669
57NUAK11.03047486
58PRPF4B1.01416061
59VRK21.01245098
60CCNB10.99798038
61NEK60.98853679
62IKBKB0.96949242
63LRRK20.94654691
64PIM20.93483067
65DYRK30.91605774
66MAP2K70.91361873
67NME10.90931248
68PIM10.90098798
69SIK30.89788109
70STK100.88970176
71YES10.88464612
72RAF10.87291583
73PAK60.85763903
74KSR20.84653347
75ADRBK20.84598937
76STK390.83106023
77TEC0.81374722
78OXSR10.80535359
79ERBB30.79794281
80MAP3K80.77798824
81CHUK0.77048263
82AURKA0.76418201
83CSNK2A20.76051950
84CHEK10.74511250
85GRK10.72576412
86SGK30.72276446
87AKT20.71207683
88JAK30.70405431
89LATS10.70288386
90STK40.68768871
91RPS6KA40.68492878
92ATM0.66241526
93MUSK0.65927529
94MAP3K60.64954244
95IKBKE0.63902834
96CDK40.63642250
97TAOK20.63107420
98WNK40.62446633
99CSNK1E0.61322034
100SGK4940.61210591
101SGK2230.61210591
102MAP3K130.61092637
103TIE10.59747437
104NTRK30.57774666
105MAPK130.57537928
106MAPK110.56267110
107EPHA40.54984693
108CDK90.52780113
109PAK20.51289710
110CDK20.46717257
111KDR0.46520210
112CLK10.46220302
113TESK10.45593176
114CSNK2A10.45272145
115PRKG10.44845348
116RPS6KA10.44845019
117TAOK30.44651627
118ABL20.43682128
119CDK10.42891345
120CSNK1G10.42640718
121IRAK20.41057503
122PBK0.39047500
123CDK120.39029444
124INSRR0.38946700
125WNK10.38719651
126IRAK10.38694096
127MARK30.38587116
128MAP3K50.37604137
129LMTK20.36785622
130ERBB40.36734972
131TYK20.36588653
132PRKCI0.36443887
133GSK3A0.35562160
134PLK20.35499408
135TRPM70.35291504
136TLK10.35214729
137PRKACB0.34797865
138NEK90.34689765
139MTOR0.34592766
140KIT0.33801053
141CDK11A0.32820495
142MAPK10.32384525
143PRKD10.31201406
144PRKD20.29968416
145GSK3B0.29600573
146CSNK1A10.26780370
147KSR10.25441259
148ILK0.24929478
149MAPK140.23269214
150FGR0.21926711
151NEK10.19131070

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.15923180
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.81463494
3DNA replication_Homo sapiens_hsa030303.17777308
4Fanconi anemia pathway_Homo sapiens_hsa034603.17407749
5Homologous recombination_Homo sapiens_hsa034403.06844007
6Basal transcription factors_Homo sapiens_hsa030223.00619494
7Vitamin B6 metabolism_Homo sapiens_hsa007502.88491353
8Base excision repair_Homo sapiens_hsa034102.79300347
9Mismatch repair_Homo sapiens_hsa034302.69546948
10Cell cycle_Homo sapiens_hsa041102.66995424
11Proteasome_Homo sapiens_hsa030502.64998763
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44649279
13Pyrimidine metabolism_Homo sapiens_hsa002402.43271354
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42586721
15RNA transport_Homo sapiens_hsa030132.42229650
16Spliceosome_Homo sapiens_hsa030402.25360788
17Nucleotide excision repair_Homo sapiens_hsa034202.10961577
18RNA degradation_Homo sapiens_hsa030182.00535008
19Non-homologous end-joining_Homo sapiens_hsa034501.87647175
20p53 signaling pathway_Homo sapiens_hsa041151.83851668
21Regulation of autophagy_Homo sapiens_hsa041401.83242634
22Purine metabolism_Homo sapiens_hsa002301.65483009
23Huntingtons disease_Homo sapiens_hsa050161.55797851
24Steroid biosynthesis_Homo sapiens_hsa001001.53036197
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.51021845
26Herpes simplex infection_Homo sapiens_hsa051681.45567794
27One carbon pool by folate_Homo sapiens_hsa006701.44175378
28Parkinsons disease_Homo sapiens_hsa050121.35769221
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.32720234
30Allograft rejection_Homo sapiens_hsa053301.31640300
31Graft-versus-host disease_Homo sapiens_hsa053321.31568601
32mRNA surveillance pathway_Homo sapiens_hsa030151.31288470
33Epstein-Barr virus infection_Homo sapiens_hsa051691.26106815
34Taste transduction_Homo sapiens_hsa047421.22191499
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.14239323
36Autoimmune thyroid disease_Homo sapiens_hsa053201.07360474
37Measles_Homo sapiens_hsa051621.06112603
38Cardiac muscle contraction_Homo sapiens_hsa042601.05972522
39Arachidonic acid metabolism_Homo sapiens_hsa005900.99856611
40Oxidative phosphorylation_Homo sapiens_hsa001900.99718341
41Fatty acid elongation_Homo sapiens_hsa000620.98693822
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93878477
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91987150
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91784316
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90393276
46Dorso-ventral axis formation_Homo sapiens_hsa043200.88811186
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88574301
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87640247
49Influenza A_Homo sapiens_hsa051640.86294242
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85314448
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83965721
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80886619
53Primary immunodeficiency_Homo sapiens_hsa053400.79966536
54Protein export_Homo sapiens_hsa030600.75664108
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75082016
56Legionellosis_Homo sapiens_hsa051340.74221585
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.74018548
58Vitamin digestion and absorption_Homo sapiens_hsa049770.73964302
59Fatty acid biosynthesis_Homo sapiens_hsa000610.73461304
60Rheumatoid arthritis_Homo sapiens_hsa053230.72940505
61Circadian rhythm_Homo sapiens_hsa047100.71330698
62Inositol phosphate metabolism_Homo sapiens_hsa005620.67959525
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65252083
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.64251661
65Sphingolipid metabolism_Homo sapiens_hsa006000.64246055
66Type I diabetes mellitus_Homo sapiens_hsa049400.64239510
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60552484
68Folate biosynthesis_Homo sapiens_hsa007900.60477801
69Leishmaniasis_Homo sapiens_hsa051400.59416039
70Selenocompound metabolism_Homo sapiens_hsa004500.57665531
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57227094
72Antigen processing and presentation_Homo sapiens_hsa046120.57080814
73Asthma_Homo sapiens_hsa053100.56832667
74Oocyte meiosis_Homo sapiens_hsa041140.55643490
75Pentose phosphate pathway_Homo sapiens_hsa000300.55208195
76Synaptic vesicle cycle_Homo sapiens_hsa047210.53570250
77Hematopoietic cell lineage_Homo sapiens_hsa046400.52795920
78Ribosome_Homo sapiens_hsa030100.52083833
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51832018
80Apoptosis_Homo sapiens_hsa042100.51629088
81Wnt signaling pathway_Homo sapiens_hsa043100.50848358
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50363699
83Sulfur relay system_Homo sapiens_hsa041220.50084711
84Other glycan degradation_Homo sapiens_hsa005110.49105703
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48905347
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48831343
87HTLV-I infection_Homo sapiens_hsa051660.48566530
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47814393
89FoxO signaling pathway_Homo sapiens_hsa040680.46594547
90Linoleic acid metabolism_Homo sapiens_hsa005910.46247563
91Hepatitis B_Homo sapiens_hsa051610.45798394
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45306024
93Olfactory transduction_Homo sapiens_hsa047400.43190063
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42185706
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41466135
96Collecting duct acid secretion_Homo sapiens_hsa049660.40980715
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40902187
98Viral carcinogenesis_Homo sapiens_hsa052030.40601163
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39170100
100TNF signaling pathway_Homo sapiens_hsa046680.36419107
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.35916618
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35296460
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34481958
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33191102
105TGF-beta signaling pathway_Homo sapiens_hsa043500.33026686
106Tuberculosis_Homo sapiens_hsa051520.32200161
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31645894
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.31572331
109Hedgehog signaling pathway_Homo sapiens_hsa043400.29994993
110MicroRNAs in cancer_Homo sapiens_hsa052060.28467423
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28185407
112Shigellosis_Homo sapiens_hsa051310.27763050
113Notch signaling pathway_Homo sapiens_hsa043300.26072215
114Prolactin signaling pathway_Homo sapiens_hsa049170.25430522
115Caffeine metabolism_Homo sapiens_hsa002320.25429299
116Hippo signaling pathway_Homo sapiens_hsa043900.23966942
117Ether lipid metabolism_Homo sapiens_hsa005650.23952798
118Alzheimers disease_Homo sapiens_hsa050100.23441243
119Malaria_Homo sapiens_hsa051440.22613719
120Glutathione metabolism_Homo sapiens_hsa004800.21709841
121Arginine and proline metabolism_Homo sapiens_hsa003300.21685528
122Pertussis_Homo sapiens_hsa051330.21298190
123Retinol metabolism_Homo sapiens_hsa008300.20146635
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20006184
125Sulfur metabolism_Homo sapiens_hsa009200.19916355
126Metabolic pathways_Homo sapiens_hsa011000.19006062
127Prostate cancer_Homo sapiens_hsa052150.18965722
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.18941149
129Ovarian steroidogenesis_Homo sapiens_hsa049130.17820766
130Systemic lupus erythematosus_Homo sapiens_hsa053220.15401878
131Phagosome_Homo sapiens_hsa041450.14704099
132Insulin secretion_Homo sapiens_hsa049110.13873184
133Nicotine addiction_Homo sapiens_hsa050330.12032898
134ABC transporters_Homo sapiens_hsa020100.09293361
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08623788
136Protein digestion and absorption_Homo sapiens_hsa049740.08321965
137Phototransduction_Homo sapiens_hsa047440.07149056
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06610810
139Small cell lung cancer_Homo sapiens_hsa052220.02096403
140Vibrio cholerae infection_Homo sapiens_hsa051100.01655190
141Tight junction_Homo sapiens_hsa045300.00505501
142Serotonergic synapse_Homo sapiens_hsa047260.00027684
143AMPK signaling pathway_Homo sapiens_hsa04152-0.0356290
144Adherens junction_Homo sapiens_hsa04520-0.0249768
145mTOR signaling pathway_Homo sapiens_hsa04150-0.0002169

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