FOXRED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.54224549
2embryonic process involved in female pregnancy (GO:0060136)6.95898763
3replication fork processing (GO:0031297)6.65146145
4transcription from mitochondrial promoter (GO:0006390)6.27378754
5DNA deamination (GO:0045006)6.18377058
6proline metabolic process (GO:0006560)6.18339101
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.75860018
8oxidative demethylation (GO:0070989)5.58275952
9positive regulation of protein homooligomerization (GO:0032464)5.54049842
10establishment of apical/basal cell polarity (GO:0035089)5.29556952
11somatic hypermutation of immunoglobulin genes (GO:0016446)5.12057050
12somatic diversification of immune receptors via somatic mutation (GO:0002566)5.12057050
13regulation of integrin activation (GO:0033623)5.07413464
14regulation of translational fidelity (GO:0006450)4.72344486
15regulation of protein homooligomerization (GO:0032462)4.69134930
16poly(A)+ mRNA export from nucleus (GO:0016973)4.64788173
17establishment of monopolar cell polarity (GO:0061162)4.52881051
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.52881051
19DNA strand renaturation (GO:0000733)4.49991005
20mitochondrial DNA metabolic process (GO:0032042)4.46397394
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.45478348
22mitotic G1 DNA damage checkpoint (GO:0031571)4.37350150
23dosage compensation (GO:0007549)4.34557677
24negative regulation of cell cycle arrest (GO:0071157)4.31923351
25viral mRNA export from host cell nucleus (GO:0046784)4.23236941
26G1 DNA damage checkpoint (GO:0044783)4.17433048
27cellular response to zinc ion (GO:0071294)4.14768731
28mRNA cleavage (GO:0006379)4.14693825
29spliceosomal tri-snRNP complex assembly (GO:0000244)4.12859406
30base-excision repair (GO:0006284)4.10339695
31telomere maintenance via semi-conservative replication (GO:0032201)4.05324631
32histone H4-K12 acetylation (GO:0043983)4.04372677
33L-serine metabolic process (GO:0006563)3.93301318
34formation of translation preinitiation complex (GO:0001731)3.92892881
35negative regulation of mRNA processing (GO:0050686)3.89909875
36DNA unwinding involved in DNA replication (GO:0006268)3.87495861
37negative regulation of JAK-STAT cascade (GO:0046426)3.82740066
38mitotic sister chromatid segregation (GO:0000070)3.74102078
39negative regulation of RNA splicing (GO:0033119)3.74032700
40DNA replication initiation (GO:0006270)3.71597183
41embryonic placenta development (GO:0001892)3.70254074
42base-excision repair, AP site formation (GO:0006285)3.69954504
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69513173
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69513173
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.69513173
46mitotic G1/S transition checkpoint (GO:0044819)3.68002189
47mitotic chromosome condensation (GO:0007076)3.66166519
48regulation of sister chromatid cohesion (GO:0007063)3.62494940
49antigen processing and presentation via MHC class Ib (GO:0002475)3.61883153
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57046749
51termination of RNA polymerase II transcription (GO:0006369)3.52647386
52double-strand break repair via nonhomologous end joining (GO:0006303)3.52424303
53non-recombinational repair (GO:0000726)3.52424303
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.52076927
55DNA strand elongation (GO:0022616)3.48899949
56sister chromatid segregation (GO:0000819)3.47629420
57DNA strand elongation involved in DNA replication (GO:0006271)3.45762913
58meiotic chromosome segregation (GO:0045132)3.45327605
59negative regulation of Ras GTPase activity (GO:0034261)3.41482993
60cellular response to ATP (GO:0071318)3.35092229
61DNA topological change (GO:0006265)3.34095909
62DNA demethylation (GO:0080111)3.33902321
63negative regulation of protein oligomerization (GO:0032460)3.32844564
64telomere maintenance via recombination (GO:0000722)3.31073993
65DNA integration (GO:0015074)3.30126434
66regulation of RNA export from nucleus (GO:0046831)3.28042037
67negative regulation of mRNA metabolic process (GO:1903312)3.27185537
68DNA replication checkpoint (GO:0000076)3.26173226
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.24830892
70regulation of cAMP-dependent protein kinase activity (GO:2000479)3.15003718
71positive regulation of protein oligomerization (GO:0032461)3.14651792
72positive regulation by host of viral transcription (GO:0043923)3.14480289
73biotin metabolic process (GO:0006768)3.14348537
74pyrimidine nucleotide catabolic process (GO:0006244)3.12562538
75nodal signaling pathway (GO:0038092)3.11745848
76protein K6-linked ubiquitination (GO:0085020)3.11246011
77regulation of protein oligomerization (GO:0032459)3.08723360
78DNA double-strand break processing (GO:0000729)3.03515827
79convergent extension (GO:0060026)3.02841189
80serine family amino acid biosynthetic process (GO:0009070)3.02834078
81resolution of meiotic recombination intermediates (GO:0000712)3.01647093
82positive regulation of developmental pigmentation (GO:0048087)2.98433540
83maturation of 5.8S rRNA (GO:0000460)2.98264341
84trophectodermal cell differentiation (GO:0001829)2.98262302
85face development (GO:0060324)2.98116089
86mitochondrial RNA metabolic process (GO:0000959)2.97277820
87telomere maintenance via telomere lengthening (GO:0010833)2.95716753
88regulation of DNA damage checkpoint (GO:2000001)2.95242769
89renal system development (GO:0072001)2.94201670
90N-glycan processing (GO:0006491)2.93121168
91nuclear envelope reassembly (GO:0031468)2.91827000
92mitotic nuclear envelope reassembly (GO:0007084)2.91827000
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.91462756
94negative regulation of stress fiber assembly (GO:0051497)2.89728515
95mRNA polyadenylation (GO:0006378)2.88781834
96positive regulation of chromosome segregation (GO:0051984)2.87886458
97kinetochore assembly (GO:0051382)2.87077139
98GDP-mannose metabolic process (GO:0019673)2.85098968
99mRNA export from nucleus (GO:0006406)2.84815255
100translesion synthesis (GO:0019985)2.83182463
101mitotic recombination (GO:0006312)2.82663637
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81477762
103regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81380419
104anatomical structure regression (GO:0060033)2.79189520
105determination of adult lifespan (GO:0008340)2.78518637
106pre-miRNA processing (GO:0031054)2.77895710
107glutamine family amino acid biosynthetic process (GO:0009084)2.76429514
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.75471149
109RNA polyadenylation (GO:0043631)2.75403841
110signal complex assembly (GO:0007172)2.74224750
111mRNA 3-end processing (GO:0031124)2.73792194
112regulation of double-strand break repair (GO:2000779)2.73711618
113DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.72980693
114regulation of mitochondrial translation (GO:0070129)2.72864083
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72449683
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.72312327
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.68663171
118mitotic sister chromatid cohesion (GO:0007064)2.65946411
119nuclear pore complex assembly (GO:0051292)2.52953708
120nucleobase biosynthetic process (GO:0046112)2.51174354
121DNA replication-dependent nucleosome organization (GO:0034723)2.49841837
122DNA replication-dependent nucleosome assembly (GO:0006335)2.49841837
123heterochromatin organization (GO:0070828)2.49837763
124folic acid-containing compound biosynthetic process (GO:0009396)2.46849547
125mitotic nuclear envelope disassembly (GO:0007077)2.43264957
126chromosome condensation (GO:0030261)2.43124329
127nuclear pore organization (GO:0006999)2.40928526
128positive regulation of DNA-dependent DNA replication (GO:2000105)2.40562478
129folic acid-containing compound metabolic process (GO:0006760)2.40092096
130kinetochore organization (GO:0051383)2.37993612
131tetrahydrofolate metabolic process (GO:0046653)2.37859675
132regulation of DNA-dependent DNA replication (GO:0090329)2.35376218
133folic acid metabolic process (GO:0046655)2.35172250
134protein localization to kinetochore (GO:0034501)2.34161267
135transcription-coupled nucleotide-excision repair (GO:0006283)2.33571889
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.31299413
137protein localization to chromosome, centromeric region (GO:0071459)2.28956989
138postreplication repair (GO:0006301)2.28865970
139DNA replication (GO:0006260)2.27162519
140regulation of translational elongation (GO:0006448)2.26804478
141pteridine-containing compound metabolic process (GO:0042558)2.25549849
142glycine metabolic process (GO:0006544)2.25483389
143rRNA transcription (GO:0009303)2.24348123
144purine nucleobase biosynthetic process (GO:0009113)2.22405764
145spliceosomal complex assembly (GO:0000245)2.21810059
146cerebellar Purkinje cell layer development (GO:0021680)2.21548817
147pteridine-containing compound biosynthetic process (GO:0042559)2.21031995
148nuclear envelope disassembly (GO:0051081)2.20938420
149membrane disassembly (GO:0030397)2.20938420
150regulation of DNA endoreduplication (GO:0032875)2.19780511
151nucleosome disassembly (GO:0006337)2.18271535
152protein-DNA complex disassembly (GO:0032986)2.18271535
153pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.17311745
154chromatin assembly (GO:0031497)2.16651840
155aspartate family amino acid catabolic process (GO:0009068)2.16570158
156DNA packaging (GO:0006323)2.15862410
157regulation of centrosome cycle (GO:0046605)2.11445482
158telomere organization (GO:0032200)2.11054741
159telomere maintenance (GO:0000723)2.11040604
160chromosome segregation (GO:0007059)2.10989326
161purine nucleotide transport (GO:0015865)2.09202500
162prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.09157748
163DNA duplex unwinding (GO:0032508)2.08501446
164IMP biosynthetic process (GO:0006188)2.07883560
165nucleotide-excision repair (GO:0006289)2.07176596
166protein complex localization (GO:0031503)2.05606012
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.05508663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.57366728
2VDR_21846776_ChIP-Seq_THP-1_Human3.09882454
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.00499796
4MYC_22102868_ChIP-Seq_BL_Human2.98638846
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.83853572
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82386904
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67686843
8AR_21909140_ChIP-Seq_LNCAP_Human2.67596310
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53956511
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43607081
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28216626
12DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.27728955
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21493053
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12043363
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08747399
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06691198
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03840844
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03840844
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03840844
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.95630566
21LXR_22292898_ChIP-Seq_THP-1_Human1.90718567
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89453227
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86467920
24* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.84537311
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.83997883
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83133593
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80592192
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75602617
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74867164
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73623785
31* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71115032
32* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.70246322
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69109111
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.67295720
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65015810
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64108493
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62982046
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62924150
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62392654
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61845370
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60884974
42ZNF263_19887448_ChIP-Seq_K562_Human1.60569001
43KDM2B_26808549_Chip-Seq_DND41_Human1.57215505
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57022233
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.56881788
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56664324
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56626202
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.55452293
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53154243
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52947709
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52909726
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52577566
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51528470
54NANOG_21062744_ChIP-ChIP_HESCs_Human1.51288347
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49443557
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49192139
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49160369
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48855751
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.47828615
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44111229
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42051492
62* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41526937
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40987499
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40096678
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40019230
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38838904
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37462886
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36125345
69* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36083806
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.34747345
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34726587
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34638995
73* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34207203
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.34081358
75XRN2_22483619_ChIP-Seq_HELA_Human1.33659375
76VDR_24763502_ChIP-Seq_THP-1_Human1.33163253
77GABP_19822575_ChIP-Seq_HepG2_Human1.32257770
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30880951
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30688337
80* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30112129
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29738765
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29635374
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.29015561
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28101440
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27679586
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27429466
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27000469
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26646267
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25417862
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.25020778
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24863450
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24640111
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24058510
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.24050659
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23974409
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23683467
97CIITA_25753668_ChIP-Seq_RAJI_Human1.23122619
98KDM5A_27292631_Chip-Seq_BREAST_Human1.20837034
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20337985
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19864381
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19695477
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19123451
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18657019
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18265194
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.18201890
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17336185
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16954410
108UTX_26944678_Chip-Seq_JUKART_Human1.16890875
109TTF2_22483619_ChIP-Seq_HELA_Human1.16604508
110* ETS1_21867929_ChIP-Seq_TH2_Mouse1.15154834
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15068826
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14743137
113MAF_26560356_Chip-Seq_TH1_Human1.13803121
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13684031
115* TFEB_21752829_ChIP-Seq_HELA_Human1.13468241
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11500079
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.11299683
118* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10169159
119RACK7_27058665_Chip-Seq_MCF-7_Human1.09329352
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.08474837
121FOXP3_21729870_ChIP-Seq_TREG_Human1.08338399
122VDR_23849224_ChIP-Seq_CD4+_Human1.07465761
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07220174
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07201222
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06957085
126MYC_18940864_ChIP-ChIP_HL60_Human1.06510271
127DCP1A_22483619_ChIP-Seq_HELA_Human1.06222106
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04664858
129CHD1_26751641_Chip-Seq_LNCaP_Human1.04528990
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04504022
131* RUNX1_22412390_ChIP-Seq_EML_Mouse1.04378852
132FOXP1_21924763_ChIP-Seq_HESCs_Human1.04090242
133POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03921122
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.03586984
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01691783
136SRF_21415370_ChIP-Seq_HL-1_Mouse1.01541632
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.00803714
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99412417
139SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96131904
140* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95761305
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95642459
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93610551
143TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93406192
144P68_20966046_ChIP-Seq_HELA_Human0.92071218
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91732201
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91633523
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89754215
148SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89319840
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87050600
150AR_21572438_ChIP-Seq_LNCaP_Human0.83844889
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83649722
152EZH2_27304074_Chip-Seq_ESCs_Mouse0.82777834
153CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82089986
154REST_18959480_ChIP-ChIP_MESCs_Mouse0.80457910
155RARB_27405468_Chip-Seq_BRAIN_Mouse0.79645383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.95042404
2MP0009278_abnormal_bone_marrow4.44183092
3MP0000566_synostosis3.37644864
4MP0005174_abnormal_tail_pigmentation3.23247583
5MP0002009_preneoplasia3.18615844
6MP0005171_absent_coat_pigmentation3.01376027
7MP0010094_abnormal_chromosome_stability2.62270235
8MP0004233_abnormal_muscle_weight2.53743521
9MP0003283_abnormal_digestive_organ2.52147466
10MP0003172_abnormal_lysosome_physiology2.49000194
11MP0005397_hematopoietic_system_phenotyp2.48703589
12MP0001545_abnormal_hematopoietic_system2.48703589
13MP0006072_abnormal_retinal_apoptosis2.36420850
14MP0003123_paternal_imprinting2.27906408
15MP0010030_abnormal_orbit_morphology2.13583582
16MP0004957_abnormal_blastocyst_morpholog2.09257700
17MP0003111_abnormal_nucleus_morphology2.08308642
18MP0000015_abnormal_ear_pigmentation2.07720850
19MP0008877_abnormal_DNA_methylation2.06680160
20MP0002396_abnormal_hematopoietic_system2.05969164
21MP0008995_early_reproductive_senescence2.03066597
22MP0008058_abnormal_DNA_repair2.00853959
23MP0005058_abnormal_lysosome_morphology1.88737652
24MP0002938_white_spotting1.85955077
25MP0005076_abnormal_cell_differentiation1.77722374
26MP0000490_abnormal_crypts_of1.76724411
27MP0001346_abnormal_lacrimal_gland1.75936118
28MP0005075_abnormal_melanosome_morpholog1.75673317
29MP0003890_abnormal_embryonic-extraembry1.74094072
30MP0010352_gastrointestinal_tract_polyps1.72005306
31MP0002234_abnormal_pharynx_morphology1.71056495
32MP0000371_diluted_coat_color1.69042768
33MP0003693_abnormal_embryo_hatching1.68824635
34MP0003786_premature_aging1.56964025
35MP0000537_abnormal_urethra_morphology1.55822723
36MP0001293_anophthalmia1.53681628
37MP0002877_abnormal_melanocyte_morpholog1.53414184
38MP0003119_abnormal_digestive_system1.53121071
39MP0002084_abnormal_developmental_patter1.52402006
40MP0003077_abnormal_cell_cycle1.50699287
41MP0004858_abnormal_nervous_system1.46280922
42MP0004133_heterotaxia1.44918444
43MP0005646_abnormal_pituitary_gland1.41518717
44MP0002086_abnormal_extraembryonic_tissu1.40181388
45MP0001697_abnormal_embryo_size1.37708245
46MP0003121_genomic_imprinting1.34944057
47MP0000685_abnormal_immune_system1.34781244
48MP0002075_abnormal_coat/hair_pigmentati1.34656296
49MP0002653_abnormal_ependyma_morphology1.33882846
50MP0002166_altered_tumor_susceptibility1.30235455
51MP0010307_abnormal_tumor_latency1.29042281
52MP0005423_abnormal_somatic_nervous1.28840771
53MP0003938_abnormal_ear_development1.26734157
54MP0004197_abnormal_fetal_growth/weight/1.25888284
55MP0003315_abnormal_perineum_morphology1.25708148
56MP0003937_abnormal_limbs/digits/tail_de1.24993312
57MP0002249_abnormal_larynx_morphology1.23686329
58MP0003122_maternal_imprinting1.22519965
59MP0000350_abnormal_cell_proliferation1.19504239
60MP0002019_abnormal_tumor_incidence1.19461223
61MP0002085_abnormal_embryonic_tissue1.19202633
62MP0000579_abnormal_nail_morphology1.18646407
63MP0000049_abnormal_middle_ear1.17926524
64MP0005394_taste/olfaction_phenotype1.16959909
65MP0005499_abnormal_olfactory_system1.16959909
66MP0009672_abnormal_birth_weight1.15946389
67MP0003942_abnormal_urinary_system1.15941702
68MP0000631_abnormal_neuroendocrine_gland1.15786383
69MP0003880_abnormal_central_pattern1.15514437
70MP0003866_abnormal_defecation1.15423009
71MP0005187_abnormal_penis_morphology1.13881355
72MP0004859_abnormal_synaptic_plasticity1.13808518
73MP0003763_abnormal_thymus_physiology1.13321377
74MP0003828_pulmonary_edema1.13093790
75MP0004808_abnormal_hematopoietic_stem1.12351610
76MP0002160_abnormal_reproductive_system1.12273121
77MP0003861_abnormal_nervous_system1.11480653
78MP0000470_abnormal_stomach_morphology1.10462002
79MP0002697_abnormal_eye_size1.09698444
80MP0003136_yellow_coat_color1.09656914
81MP0000689_abnormal_spleen_morphology1.05565857
82MP0000703_abnormal_thymus_morphology1.05280711
83MP0002735_abnormal_chemical_nociception1.04892277
84MP0004264_abnormal_extraembryonic_tissu1.04489655
85MP0000778_abnormal_nervous_system1.04288950
86MP0008789_abnormal_olfactory_epithelium1.03685167
87MP0008932_abnormal_embryonic_tissue1.03235467
88MP0005257_abnormal_intraocular_pressure1.03121076
89MP0002398_abnormal_bone_marrow1.02076983
90MP0002080_prenatal_lethality1.00711395
91MP0001186_pigmentation_phenotype1.00610934
92MP0001730_embryonic_growth_arrest0.99353024
93MP0000639_abnormal_adrenal_gland0.99298824
94MP0002006_tumorigenesis0.99073867
95MP0001672_abnormal_embryogenesis/_devel0.99063627
96MP0005380_embryogenesis_phenotype0.99063627
97MP0009053_abnormal_anal_canal0.97970637
98MP0002184_abnormal_innervation0.95712181
99MP0000313_abnormal_cell_death0.95282498
100MP0000534_abnormal_ureter_morphology0.94942278
101MP0003385_abnormal_body_wall0.93332232
102MP0002098_abnormal_vibrissa_morphology0.93015906
103MP0002405_respiratory_system_inflammati0.91298091
104MP0002064_seizures0.90294825
105MP0002063_abnormal_learning/memory/cond0.90058090
106MP0003635_abnormal_synaptic_transmissio0.89771429
107MP0002233_abnormal_nose_morphology0.89713965
108MP0002557_abnormal_social/conspecific_i0.89483545
109MP0001529_abnormal_vocalization0.89140334
110MP0002095_abnormal_skin_pigmentation0.89096918
111MP0002116_abnormal_craniofacial_bone0.88824995
112MP0001968_abnormal_touch/_nociception0.88607430
113MP0003755_abnormal_palate_morphology0.88540519
114MP0002736_abnormal_nociception_after0.88150538
115MP0002210_abnormal_sex_determination0.85960646
116MP0002722_abnormal_immune_system0.85524423
117MP0002282_abnormal_trachea_morphology0.85006887
118MP0002152_abnormal_brain_morphology0.84569312
119MP0002932_abnormal_joint_morphology0.83258245
120MP0001873_stomach_inflammation0.82721119
121MP0003943_abnormal_hepatobiliary_system0.82244888
122MP0005408_hypopigmentation0.81886543
123MP0000678_abnormal_parathyroid_gland0.79310386
124MP0003115_abnormal_respiratory_system0.78625102
125MP0002114_abnormal_axial_skeleton0.78576242
126MP0005623_abnormal_meninges_morphology0.78387028
127MP0009780_abnormal_chondrocyte_physiolo0.78130773
128MP0002572_abnormal_emotion/affect_behav0.78058782
129MP0003453_abnormal_keratinocyte_physiol0.77807334
130MP0002734_abnormal_mechanical_nocicepti0.77136488
131MP0002089_abnormal_postnatal_growth/wei0.76858868
132MP0002269_muscular_atrophy0.76689742
133MP0003567_abnormal_fetal_cardiomyocyte0.76263823
134MP0003984_embryonic_growth_retardation0.75895098
135MP0003045_fibrosis0.75398354
136MP0001324_abnormal_eye_pigmentation0.74638158
137MP0006276_abnormal_autonomic_nervous0.74275040
138MP0005464_abnormal_platelet_physiology0.73871371
139MP0003787_abnormal_imprinting0.73402884
140MP0002909_abnormal_adrenal_gland0.73317494
141MP0005220_abnormal_exocrine_pancreas0.72885583
142MP0002088_abnormal_embryonic_growth/wei0.72786427
143MP0009697_abnormal_copulation0.72760143
144MP0003718_maternal_effect0.72398834
145MP0000681_abnormal_thyroid_gland0.71972548
146MP0000428_abnormal_craniofacial_morphol0.71291211
147MP0009745_abnormal_behavioral_response0.71216171
148MP0005645_abnormal_hypothalamus_physiol0.69253506
149MP0006292_abnormal_olfactory_placode0.68223411
150MP0002111_abnormal_tail_morphology0.65694104
151MP0001145_abnormal_male_reproductive0.64999405
152MP0004142_abnormal_muscle_tone0.64045125
153MP0000462_abnormal_digestive_system0.63598508
154MP0005253_abnormal_eye_physiology0.63585911
155MP0009046_muscle_twitch0.63106394
156MP0000569_abnormal_digit_pigmentation0.61930985
157MP0008770_decreased_survivor_rate0.61852643
158MP0000955_abnormal_spinal_cord0.61813172
159MP0009115_abnormal_fat_cell0.61403578
160MP0000716_abnormal_immune_system0.60619185
161MP0001340_abnormal_eyelid_morphology0.60584796
162MP0002163_abnormal_gland_morphology0.60439212
163MP0008007_abnormal_cellular_replicative0.60197876

Predicted human phenotypes

RankGene SetZ-score
1Poikiloderma (HP:0001029)5.04943399
2Annular pancreas (HP:0001734)4.73995591
3Rib fusion (HP:0000902)4.45715252
4Facial hemangioma (HP:0000329)4.35338054
5Birth length less than 3rd percentile (HP:0003561)4.02608283
6Volvulus (HP:0002580)4.01930208
7Pustule (HP:0200039)3.98472979
8Chromsome breakage (HP:0040012)3.98242282
9Concave nail (HP:0001598)3.85379933
10Urinary glycosaminoglycan excretion (HP:0003541)3.80116233
11Mucopolysacchariduria (HP:0008155)3.80116233
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79505776
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.58667637
14Abnormality of polysaccharide metabolism (HP:0011012)3.58667637
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.58667637
16Abnormality of cochlea (HP:0000375)3.58063021
17Rectal fistula (HP:0100590)3.54107624
18Rectovaginal fistula (HP:0000143)3.54107624
19Albinism (HP:0001022)3.49729628
20Increased IgM level (HP:0003496)3.47063370
21Intestinal fistula (HP:0100819)3.40012289
22Dysostosis multiplex (HP:0000943)3.36128764
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31057272
24Basal cell carcinoma (HP:0002671)3.22559286
25Vaginal fistula (HP:0004320)3.22505899
26Ulnar bowing (HP:0003031)3.19282313
27Morphological abnormality of the inner ear (HP:0011390)3.16082274
28Intestinal atresia (HP:0011100)3.14967649
29Acute lymphatic leukemia (HP:0006721)3.07951212
30Breast hypoplasia (HP:0003187)3.06816581
31Tongue fasciculations (HP:0001308)2.97748597
32Short chin (HP:0000331)2.97068966
33Broad alveolar ridges (HP:0000187)2.96736770
34Congenital hip dislocation (HP:0001374)2.94868273
35Premature graying of hair (HP:0002216)2.94807872
36Turricephaly (HP:0000262)2.94386237
37Orthostatic hypotension (HP:0001278)2.87930589
38Anteriorly placed anus (HP:0001545)2.86188378
39Short humerus (HP:0005792)2.85739608
40Premature skin wrinkling (HP:0100678)2.83839416
41Muscle fiber atrophy (HP:0100295)2.81211806
42Squamous cell carcinoma (HP:0002860)2.79481657
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.77743905
44Vertebral hypoplasia (HP:0008417)2.77743905
45Abnormality of male internal genitalia (HP:0000022)2.76627715
46Back pain (HP:0003418)2.76515265
47Aplasia/hypoplasia of the humerus (HP:0006507)2.71347834
48Hypotelorism (HP:0000601)2.69076949
49Alopecia of scalp (HP:0002293)2.67466096
50Joint stiffness (HP:0001387)2.61033453
51Absent thumb (HP:0009777)2.60906361
52Neoplasm of the oral cavity (HP:0100649)2.60472884
53Male infertility (HP:0003251)2.54953857
54Abnormality of the astrocytes (HP:0100707)2.51553448
55Astrocytoma (HP:0009592)2.51553448
56Muscle fibrillation (HP:0010546)2.51407066
57Hyperacusis (HP:0010780)2.50829466
58Growth hormone excess (HP:0000845)2.50081612
59Meckel diverticulum (HP:0002245)2.49934221
60IgA deficiency (HP:0002720)2.43485956
61Large for gestational age (HP:0001520)2.41218952
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.37349193
63Increased nuchal translucency (HP:0010880)2.36356515
64Abnormal number of incisors (HP:0011064)2.35066642
65Abnormality of the ileum (HP:0001549)2.32423376
66Patellar aplasia (HP:0006443)2.32045635
67Selective tooth agenesis (HP:0001592)2.29040482
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.28578124
69Spinal muscular atrophy (HP:0007269)2.28135036
70Abnormality of the carotid arteries (HP:0005344)2.28037269
71Bowing of the arm (HP:0006488)2.26167523
72Bowed forearm bones (HP:0003956)2.26167523
73Septate vagina (HP:0001153)2.25500525
74Dysautonomia (HP:0002459)2.23587317
75Hypochromic microcytic anemia (HP:0004840)2.22394280
76Type 2 muscle fiber atrophy (HP:0003554)2.21593233
77Abnormality of glycolysis (HP:0004366)2.19330129
78Absent radius (HP:0003974)2.19306675
79Hamartoma (HP:0010566)2.17332286
80Narrow nasal bridge (HP:0000446)2.12186556
81Triphalangeal thumb (HP:0001199)2.10836836
82Ectopic kidney (HP:0000086)2.10070097
83Absent forearm bone (HP:0003953)2.09205964
84Aplasia involving forearm bones (HP:0009822)2.09205964
85Abnormality of T cell physiology (HP:0011840)2.05462602
86Clumsiness (HP:0002312)2.05012695
87Aplasia/Hypoplasia of the patella (HP:0006498)2.04944047
88Alacrima (HP:0000522)2.03927469
89Coronal craniosynostosis (HP:0004440)2.03545303
90Abnormality of the preputium (HP:0100587)2.03217114
91Tented upper lip vermilion (HP:0010804)2.02967416
92Ependymoma (HP:0002888)2.01743637
93Increased number of teeth (HP:0011069)2.01654523
94Cerebral aneurysm (HP:0004944)2.00777574
95Split hand (HP:0001171)1.98370663
96Abnormality of chromosome stability (HP:0003220)1.97735614
97Glioma (HP:0009733)1.96380231
98Oligodactyly (HP:0012165)1.95503498
99High anterior hairline (HP:0009890)1.95500650
100Pancreatic islet-cell hyperplasia (HP:0004510)1.94861774
101Hypotrichosis (HP:0001006)1.93937519
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93534729
103Insomnia (HP:0100785)1.92310406
104Abnormality of the labia minora (HP:0012880)1.91425767
105Short thumb (HP:0009778)1.90929670
106Choanal stenosis (HP:0000452)1.90639835
107Abnormal hemoglobin (HP:0011902)1.90152100
108Neoplasm of the adrenal cortex (HP:0100641)1.88979971
109Shawl scrotum (HP:0000049)1.87447826
110Bifid uvula (HP:0000193)1.86366139
111Hypochromic anemia (HP:0001931)1.85503671
112Myelodysplasia (HP:0002863)1.83517197
113Esophageal atresia (HP:0002032)1.82577574
114Progressive neurologic deterioration (HP:0002344)1.81974857
115Decreased testicular size (HP:0008734)1.80662074
116Overriding aorta (HP:0002623)1.79798214
117Fatigue (HP:0012378)1.79728538
118Atresia of the external auditory canal (HP:0000413)1.79150123
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79066054
120Gastrointestinal atresia (HP:0002589)1.78656092
121Abnormality of the aortic arch (HP:0012303)1.78521217
122Gait imbalance (HP:0002141)1.78338893
123Slender long bone (HP:0003100)1.77446937
124Testicular atrophy (HP:0000029)1.77051712
125Capillary hemangiomas (HP:0005306)1.74981515
126Hypercortisolism (HP:0001578)1.74960828
127Polycystic kidney dysplasia (HP:0000113)1.74296070
128Congenital primary aphakia (HP:0007707)1.73337697
129Colitis (HP:0002583)1.72367274
130Abnormality of the phalanges of the hallux (HP:0010057)1.72289980
131Hypokinesia (HP:0002375)1.72233323
132Visual hallucinations (HP:0002367)1.72105642
133Urethral obstruction (HP:0000796)1.71377270
134Cystic liver disease (HP:0006706)1.70929687
135Abnormality of chromosome segregation (HP:0002916)1.70889124
136Vertebral fusion (HP:0002948)1.70728673
137Elfin facies (HP:0004428)1.69098054
138Bifid scrotum (HP:0000048)1.67694928
139Abnormality of the parathyroid morphology (HP:0011766)1.66958954
140Ocular albinism (HP:0001107)1.66254507
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65256457
142Absent epiphyses (HP:0010577)1.65256457
143Increased serum pyruvate (HP:0003542)1.64798083
144Renal agenesis (HP:0000104)1.62659198
145Microglossia (HP:0000171)1.62551105
146Cerebral hypomyelination (HP:0006808)1.62448478
147Small intestinal stenosis (HP:0012848)1.61350329
148Duodenal stenosis (HP:0100867)1.61350329
149Horseshoe kidney (HP:0000085)1.58589273
150Unilateral renal agenesis (HP:0000122)1.58269223
151Severe muscular hypotonia (HP:0006829)1.57917944
152Cutaneous finger syndactyly (HP:0010554)1.56067939
153Renal duplication (HP:0000075)1.55655750
154Broad distal phalanx of finger (HP:0009836)1.55165270
155Renal dysplasia (HP:0000110)1.53690477
156Trigonocephaly (HP:0000243)1.51812967
157Cafe-au-lait spot (HP:0000957)1.51351574
158Gastroesophageal reflux (HP:0002020)1.51055993
159Abnormality of the diencephalon (HP:0010662)1.48580521
160Sloping forehead (HP:0000340)1.47829307
161Embryonal neoplasm (HP:0002898)1.46341846
162Duplication of thumb phalanx (HP:0009942)1.45489083
163Renovascular hypertension (HP:0100817)1.44999738
164Hemiparesis (HP:0001269)1.44285794
165Sparse lateral eyebrow (HP:0005338)1.44230860
166Abnormality of the duodenum (HP:0002246)1.44102032
167Preauricular skin tag (HP:0000384)1.43145275
168Anal stenosis (HP:0002025)1.42998114
169High pitched voice (HP:0001620)1.41221007
170Abnormal lung lobation (HP:0002101)1.39923149
171Progressive cerebellar ataxia (HP:0002073)1.39379518
172Choanal atresia (HP:0000453)1.38710719
173Retinal dysplasia (HP:0007973)1.38528143
174Type II lissencephaly (HP:0007260)1.37846204
175Pseudobulbar signs (HP:0002200)1.36538252
176Small hand (HP:0200055)1.35763671
177Hyperglycinemia (HP:0002154)1.35645109
178Cutaneous syndactyly (HP:0012725)1.35512243
179Proximal placement of thumb (HP:0009623)1.34895741
180Abnormality of glycine metabolism (HP:0010895)1.34595720
181Abnormality of serine family amino acid metabolism (HP:0010894)1.34595720
182Pterygium (HP:0001059)1.34434014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.15219263
2MAP3K64.40182943
3DDR24.22193266
4MAPK154.07301873
5MAP3K113.42754882
6MATK3.14768923
7PRKD33.14196722
8DAPK12.92882401
9VRK22.81735237
10TYRO32.59671736
11FGR2.46216801
12UHMK12.35518708
13PINK12.29044218
14SMG12.22024606
15BUB12.09245137
16BMX2.06950434
17BRSK12.04436454
18TTK1.99920306
19PRKD21.96279170
20YES11.96172815
21PIM21.92450498
22PDGFRA1.84464731
23SRPK11.79540350
24CDK71.75415889
25WNK41.74634456
26DYRK31.73019198
27CSK1.72362573
28CAMK1G1.71145622
29DYRK1B1.70887996
30EEF2K1.61607245
31CDK61.58135964
32EIF2AK11.53212650
33PIM11.50734141
34NEK11.49141726
35PNCK1.44543181
36TSSK61.38178314
37PAK61.36354472
38HIPK21.33903553
39ZAK1.27470396
40TRIB31.25003384
41NME11.21969023
42BRSK21.19778520
43AKT31.17241257
44CSNK1A1L1.17082191
45CHEK21.16638057
46CSNK1G31.16245487
47RPS6KC11.15354273
48RPS6KL11.15354273
49TAF11.14805319
50MAP4K11.14554432
51RPS6KB21.13483362
52PLK41.12888625
53CDC42BPA1.09659227
54BRD41.09325556
55RIPK11.08492582
56TRPM71.08088047
57PLK31.03826723
58RPS6KA61.02089426
59MAPKAPK51.01893177
60ATR1.01621800
61TNK21.01500742
62AKT20.96520222
63LATS10.96501245
64MARK10.93734647
65MAPK110.92692183
66MAP3K90.89612432
67CSNK1G10.88558418
68GSK3A0.87820781
69STK390.87396127
70CSNK1G20.84936503
71RAF10.84787586
72MAP3K100.84643649
73RPS6KB10.84539759
74TAOK20.83653851
75BCKDK0.80536145
76CDC70.80461419
77NTRK30.79521547
78SIK10.79136998
79CDK190.78507102
80MINK10.76821214
81PLK10.74678604
82SCYL20.74377842
83MTOR0.73833949
84MAPK130.73463996
85FLT30.72984710
86PBK0.71616357
87CCNB10.69267015
88ALK0.67574324
89MET0.67478513
90CSNK1E0.67431257
91CDK120.66287142
92CDK40.65386016
93IRAK30.64279209
94NUAK10.64258314
95STK38L0.64227546
96RPS6KA10.64096399
97PRKDC0.63106471
98TRIM280.62372650
99ERBB30.61894892
100NEK20.61799946
101NME20.61535377
102KSR20.60950146
103MAP2K30.60778164
104FGFR20.60435091
105LYN0.60194709
106CASK0.60131523
107CDK20.59434307
108STK160.59088303
109VRK10.59013057
110MAPKAPK30.58736668
111BRAF0.58734258
112CDK150.57500626
113CDK30.57158086
114EPHA40.56098882
115CDK180.54050942
116PASK0.53927574
117PRPF4B0.53754819
118PHKG20.53535378
119PHKG10.53535378
120CDK11A0.53399591
121BMPR1B0.52303117
122PRKCI0.51757474
123PKN20.51422769
124PRKAA10.50732958
125TAOK10.49329160
126EPHA20.48131375
127TLK10.46853460
128WEE10.46775822
129PLK20.46297283
130CDK140.45181471
131CHEK10.44592824
132EGFR0.43748214
133EIF2AK20.43197659
134INSRR0.43163807
135NTRK20.43060222
136SIK20.42546876
137LATS20.41947971
138ZAP700.41845851
139BTK0.41602160
140MAPK140.40600582
141MAPK30.40055558
142KIT0.39764165
143MAPK10.39625277
144CAMK1D0.39051341
145PDGFRB0.38331332
146MAPK100.36955907
147MAP3K120.36659675
148LCK0.36193693
149ATM0.36145178
150CSNK2A10.36041237
151PAK40.35937856
152AURKB0.34018748
153CSNK2A20.32897980
154AURKA0.32473661
155CDK80.31559635
156CDK90.31469481
157CHUK0.29660095
158CDK10.29423766
159AKT10.27577391
160MAPK40.24117766
161GSK3B0.24059171
162MAPKAPK20.23872809
163ERN10.22736675

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.27945230
2Base excision repair_Homo sapiens_hsa034104.24463009
3DNA replication_Homo sapiens_hsa030303.85926292
4Fatty acid biosynthesis_Homo sapiens_hsa000613.30466152
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.79348208
6mRNA surveillance pathway_Homo sapiens_hsa030152.11852441
7Spliceosome_Homo sapiens_hsa030402.07366645
8Vitamin B6 metabolism_Homo sapiens_hsa007502.05398775
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02046911
10mTOR signaling pathway_Homo sapiens_hsa041501.99569322
11Nucleotide excision repair_Homo sapiens_hsa034201.97372600
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94451686
13RNA transport_Homo sapiens_hsa030131.94325009
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.73378526
15Notch signaling pathway_Homo sapiens_hsa043301.71529744
16Homologous recombination_Homo sapiens_hsa034401.69241909
17Protein export_Homo sapiens_hsa030601.62734074
18Circadian rhythm_Homo sapiens_hsa047101.62177882
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56077052
20Fanconi anemia pathway_Homo sapiens_hsa034601.53799248
21Cell cycle_Homo sapiens_hsa041101.52762080
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.45294172
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40170064
24p53 signaling pathway_Homo sapiens_hsa041151.38618003
25Ribosome_Homo sapiens_hsa030101.38500081
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37956311
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35511411
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.34828506
29Pyruvate metabolism_Homo sapiens_hsa006201.34462984
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.34072559
31Primary immunodeficiency_Homo sapiens_hsa053401.33325390
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.31726077
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27236360
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24155525
35Steroid biosynthesis_Homo sapiens_hsa001001.23229713
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21271315
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21138760
38Oocyte meiosis_Homo sapiens_hsa041141.17359444
39Shigellosis_Homo sapiens_hsa051311.15888008
40Hedgehog signaling pathway_Homo sapiens_hsa043401.15817911
41Bladder cancer_Homo sapiens_hsa052191.10660453
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09722682
43Chronic myeloid leukemia_Homo sapiens_hsa052201.08875301
44Hippo signaling pathway_Homo sapiens_hsa043901.08698369
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06710722
46VEGF signaling pathway_Homo sapiens_hsa043701.06169948
47Sulfur relay system_Homo sapiens_hsa041221.05301589
48Carbon metabolism_Homo sapiens_hsa012001.05135299
49Selenocompound metabolism_Homo sapiens_hsa004501.04605028
50Propanoate metabolism_Homo sapiens_hsa006401.04347454
51Colorectal cancer_Homo sapiens_hsa052101.01609732
52Acute myeloid leukemia_Homo sapiens_hsa052210.99835723
53Fatty acid metabolism_Homo sapiens_hsa012120.99804511
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95990902
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94937225
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94582005
57Fructose and mannose metabolism_Homo sapiens_hsa000510.93326485
58RNA degradation_Homo sapiens_hsa030180.88157790
59Butanoate metabolism_Homo sapiens_hsa006500.87603578
60B cell receptor signaling pathway_Homo sapiens_hsa046620.87532604
61Wnt signaling pathway_Homo sapiens_hsa043100.86659645
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.86596439
63Purine metabolism_Homo sapiens_hsa002300.85073735
64Nicotine addiction_Homo sapiens_hsa050330.82695904
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82623310
66Arginine biosynthesis_Homo sapiens_hsa002200.80379434
67Fatty acid elongation_Homo sapiens_hsa000620.80219808
68Basal transcription factors_Homo sapiens_hsa030220.80147311
69Adherens junction_Homo sapiens_hsa045200.76879918
70Biosynthesis of amino acids_Homo sapiens_hsa012300.76628165
71N-Glycan biosynthesis_Homo sapiens_hsa005100.76120904
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73722781
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73702461
74MicroRNAs in cancer_Homo sapiens_hsa052060.70754844
75Vibrio cholerae infection_Homo sapiens_hsa051100.70610565
76ErbB signaling pathway_Homo sapiens_hsa040120.69929660
77Viral carcinogenesis_Homo sapiens_hsa052030.69225188
78Non-small cell lung cancer_Homo sapiens_hsa052230.68664016
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68138954
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.66598049
81Proteasome_Homo sapiens_hsa030500.64435264
82Galactose metabolism_Homo sapiens_hsa000520.64345614
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63388310
84TGF-beta signaling pathway_Homo sapiens_hsa043500.63312978
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63022522
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62921125
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62684777
88Basal cell carcinoma_Homo sapiens_hsa052170.61780175
89HTLV-I infection_Homo sapiens_hsa051660.61317131
90Gap junction_Homo sapiens_hsa045400.61160036
91AMPK signaling pathway_Homo sapiens_hsa041520.60887522
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59132120
93Lysine degradation_Homo sapiens_hsa003100.58992182
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58818997
95Hepatitis B_Homo sapiens_hsa051610.58678027
96Estrogen signaling pathway_Homo sapiens_hsa049150.58062894
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56994798
98Choline metabolism in cancer_Homo sapiens_hsa052310.56711003
99Herpes simplex infection_Homo sapiens_hsa051680.56548674
100Pentose phosphate pathway_Homo sapiens_hsa000300.55930351
101Insulin secretion_Homo sapiens_hsa049110.55832915
102Endometrial cancer_Homo sapiens_hsa052130.55369735
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55079207
104Vitamin digestion and absorption_Homo sapiens_hsa049770.54635386
105Lysosome_Homo sapiens_hsa041420.54282765
106Synaptic vesicle cycle_Homo sapiens_hsa047210.54148308
107Oxidative phosphorylation_Homo sapiens_hsa001900.54100805
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53207272
109Metabolic pathways_Homo sapiens_hsa011000.53037149
110Folate biosynthesis_Homo sapiens_hsa007900.52900515
111Insulin signaling pathway_Homo sapiens_hsa049100.52445445
112Epstein-Barr virus infection_Homo sapiens_hsa051690.52417477
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51799734
114Measles_Homo sapiens_hsa051620.51403605
115Legionellosis_Homo sapiens_hsa051340.51335226
116Dorso-ventral axis formation_Homo sapiens_hsa043200.50889823
117Huntingtons disease_Homo sapiens_hsa050160.50853354
118MAPK signaling pathway_Homo sapiens_hsa040100.49808395
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49481131
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47592383
121Glucagon signaling pathway_Homo sapiens_hsa049220.46319119
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45859791
123beta-Alanine metabolism_Homo sapiens_hsa004100.45468743
124Prolactin signaling pathway_Homo sapiens_hsa049170.45464042
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44298193
126Phototransduction_Homo sapiens_hsa047440.43626962
127Small cell lung cancer_Homo sapiens_hsa052220.43594430
128Thyroid hormone synthesis_Homo sapiens_hsa049180.43409901
129Cocaine addiction_Homo sapiens_hsa050300.43398409
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.43263980
131Phenylalanine metabolism_Homo sapiens_hsa003600.42777197
132Pancreatic cancer_Homo sapiens_hsa052120.42221774
133Amphetamine addiction_Homo sapiens_hsa050310.41705086
134Parkinsons disease_Homo sapiens_hsa050120.41162805
135HIF-1 signaling pathway_Homo sapiens_hsa040660.40998533
136Thyroid cancer_Homo sapiens_hsa052160.40997337
137Melanogenesis_Homo sapiens_hsa049160.40523377
138Arginine and proline metabolism_Homo sapiens_hsa003300.39935181
139Glioma_Homo sapiens_hsa052140.39771240
140GnRH signaling pathway_Homo sapiens_hsa049120.39688798
141Pyrimidine metabolism_Homo sapiens_hsa002400.38964317
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38347270
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37900229
144RNA polymerase_Homo sapiens_hsa030200.37882190
145One carbon pool by folate_Homo sapiens_hsa006700.37401014
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36583801
147Circadian entrainment_Homo sapiens_hsa047130.36360957
148ABC transporters_Homo sapiens_hsa020100.36136987
149Proteoglycans in cancer_Homo sapiens_hsa052050.35921942
150Long-term depression_Homo sapiens_hsa047300.35574078
151Platelet activation_Homo sapiens_hsa046110.35402078
152Glutamatergic synapse_Homo sapiens_hsa047240.35271295
153Tryptophan metabolism_Homo sapiens_hsa003800.35166994
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34697094
155Non-homologous end-joining_Homo sapiens_hsa034500.33214222
156GABAergic synapse_Homo sapiens_hsa047270.32859897

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