FPGT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)5.73850330
2axon ensheathment in central nervous system (GO:0032291)5.51819859
3central nervous system myelination (GO:0022010)5.51819859
4ether lipid metabolic process (GO:0046485)4.83357244
5negative regulation of neurotransmitter secretion (GO:0046929)4.75236718
6L-phenylalanine catabolic process (GO:0006559)4.28254805
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.28254805
8cholesterol biosynthetic process (GO:0006695)4.01876244
9long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.01875392
10axon ensheathment (GO:0008366)4.00692699
11ensheathment of neurons (GO:0007272)4.00692699
12myelination (GO:0042552)3.97055953
13neutrophil activation involved in immune response (GO:0002283)3.91697784
14ER overload response (GO:0006983)3.90025299
15negative regulation of neurotransmitter transport (GO:0051589)3.79315546
16synapsis (GO:0007129)3.78017656
17asymmetric protein localization (GO:0008105)3.66297625
18nucleotide transmembrane transport (GO:1901679)3.63984603
19ribosome assembly (GO:0042255)3.63049231
20negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.62896889
21L-phenylalanine metabolic process (GO:0006558)3.61799679
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61799679
23branched-chain amino acid catabolic process (GO:0009083)3.61363244
24apical protein localization (GO:0045176)3.60405356
25fatty-acyl-CoA biosynthetic process (GO:0046949)3.59694588
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57465361
27glycerophospholipid catabolic process (GO:0046475)3.51775185
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.41696093
29eye photoreceptor cell differentiation (GO:0001754)3.40252904
30photoreceptor cell differentiation (GO:0046530)3.40252904
31sterol biosynthetic process (GO:0016126)3.38682851
32negative regulation of protein localization to plasma membrane (GO:1903077)3.33977223
33glycerol ether metabolic process (GO:0006662)3.28304865
34carnitine metabolic process (GO:0009437)3.25279058
35signal peptide processing (GO:0006465)3.24693051
36polyol biosynthetic process (GO:0046173)3.24551402
37iron ion import (GO:0097286)3.18956403
38platelet dense granule organization (GO:0060155)3.18667337
39Golgi transport vesicle coating (GO:0048200)3.18243940
40COPI coating of Golgi vesicle (GO:0048205)3.18243940
41regulation of meiosis I (GO:0060631)3.15361913
42magnesium ion transport (GO:0015693)3.12925904
43fatty-acyl-CoA metabolic process (GO:0035337)3.12772746
44C4-dicarboxylate transport (GO:0015740)3.12076900
45amyloid precursor protein metabolic process (GO:0042982)3.11714249
46long-chain fatty acid biosynthetic process (GO:0042759)3.11324174
47oligosaccharide catabolic process (GO:0009313)3.09502944
48branched-chain amino acid metabolic process (GO:0009081)3.08778295
49very-low-density lipoprotein particle assembly (GO:0034379)3.04157430
50resolution of meiotic recombination intermediates (GO:0000712)3.03673751
51very long-chain fatty acid metabolic process (GO:0000038)3.03084139
52presynaptic membrane assembly (GO:0097105)3.03038079
53response to lipoprotein particle (GO:0055094)3.02817737
54cellular response to hepatocyte growth factor stimulus (GO:0035729)2.99256792
55response to hepatocyte growth factor (GO:0035728)2.99256792
56endocrine pancreas development (GO:0031018)2.98855183
57peptidyl-tyrosine autophosphorylation (GO:0038083)2.98750120
58fatty acid beta-oxidation (GO:0006635)2.96531543
59acyl-CoA biosynthetic process (GO:0071616)2.93455015
60thioester biosynthetic process (GO:0035384)2.93455015
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92010554
62myelin maintenance (GO:0043217)2.90938461
63regulation of Golgi to plasma membrane protein transport (GO:0042996)2.90767894
64ether metabolic process (GO:0018904)2.90579676
65protein palmitoylation (GO:0018345)2.90275391
66aromatic amino acid family catabolic process (GO:0009074)2.89011808
67regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88822978
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.86024955
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86024955
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86024955
71presynaptic membrane organization (GO:0097090)2.85273441
72peptide catabolic process (GO:0043171)2.83446339
73positive regulation of cellular amide metabolic process (GO:0034250)2.80625632
74response to pheromone (GO:0019236)2.80608606
75short-chain fatty acid metabolic process (GO:0046459)2.79340662
76detection of molecule of bacterial origin (GO:0032490)2.79181150
77amyloid precursor protein catabolic process (GO:0042987)2.76376108
78valine metabolic process (GO:0006573)2.75276687
79phospholipid homeostasis (GO:0055091)2.75154500
80peptide hormone processing (GO:0016486)2.74886106
81response to dietary excess (GO:0002021)2.73334879
82negative regulation of complement activation (GO:0045916)2.71392175
83mitotic sister chromatid cohesion (GO:0007064)2.71033669
84lipid oxidation (GO:0034440)2.70641483
85oligodendrocyte differentiation (GO:0048709)2.69639372
86isoprenoid biosynthetic process (GO:0008299)2.68688908
87fatty acid oxidation (GO:0019395)2.67359945
88positive regulation of oligodendrocyte differentiation (GO:0048714)2.64303355
89cell morphogenesis involved in neuron differentiation (GO:0048667)2.64221653
90nucleotide transport (GO:0006862)2.64201022
91fat-soluble vitamin biosynthetic process (GO:0042362)2.62470998
92sphingomyelin metabolic process (GO:0006684)2.62036921
93response to hydroperoxide (GO:0033194)2.61485316
94response to redox state (GO:0051775)2.61442799
95regulation of collateral sprouting (GO:0048670)2.61291087
96sphingosine metabolic process (GO:0006670)2.61106806
97phospholipid scrambling (GO:0017121)2.60490883
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59512399
99negative regulation of JUN kinase activity (GO:0043508)2.58570490
100response to methylmercury (GO:0051597)2.57818294
101sequestering of metal ion (GO:0051238)2.57113085
102pH reduction (GO:0045851)2.57063932
103creatine metabolic process (GO:0006600)2.55740931
104intracellular pH reduction (GO:0051452)2.55240596
105negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.54973104
106tyrosine metabolic process (GO:0006570)2.54769227
107proteasome assembly (GO:0043248)2.54141507
108positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51076555
109fatty acid catabolic process (GO:0009062)2.50745447
110substantia nigra development (GO:0021762)2.50611444
111regulation of sulfur metabolic process (GO:0042762)2.50300088
112cellular response to gamma radiation (GO:0071480)2.48725959
113regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.48680209
114histamine secretion (GO:0001821)2.46606676
115COPII vesicle coating (GO:0048208)2.45269918
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45233588
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.45233588
118tricarboxylic acid cycle (GO:0006099)2.45157987
119protein targeting to vacuole (GO:0006623)2.44718874
120protein targeting to lysosome (GO:0006622)2.44718874
121establishment of protein localization to vacuole (GO:0072666)2.44718874
122negative regulation of protein activation cascade (GO:2000258)2.44681109
123pyrimidine-containing compound transmembrane transport (GO:0072531)2.44217752
124metaphase plate congression (GO:0051310)2.43809497
125amino-acid betaine metabolic process (GO:0006577)2.43601438
126regulation of acyl-CoA biosynthetic process (GO:0050812)2.42739186
127regulation of interferon-beta biosynthetic process (GO:0045357)2.42579331
128regulation of protein glycosylation (GO:0060049)2.42239828
129phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.41928903
130macroautophagy (GO:0016236)2.41084941
131virion attachment to host cell (GO:0019062)2.40488195
132adhesion of symbiont to host cell (GO:0044650)2.40488195
133establishment of chromosome localization (GO:0051303)2.39224816
134Golgi to plasma membrane protein transport (GO:0043001)2.37894025
135plasma lipoprotein particle assembly (GO:0034377)2.37724404
136peroxisome fission (GO:0016559)2.35612712
137regulation of lipoprotein metabolic process (GO:0050746)2.33939733
138neuronal ion channel clustering (GO:0045161)2.33836817
139retinal metabolic process (GO:0042574)2.33712259
140modulation by symbiont of host defense response (GO:0052031)2.33590734
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33590734
142modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33590734
143positive regulation by organism of defense response of other organism involved in symbiotic interact2.33590734
144modulation by symbiont of host immune response (GO:0052553)2.33590734
145positive regulation by symbiont of host defense response (GO:0052509)2.33590734
146glycoside metabolic process (GO:0016137)2.31232453
147interleukin-6-mediated signaling pathway (GO:0070102)2.29779206
148negative regulation of digestive system process (GO:0060457)2.29445246
149aldehyde catabolic process (GO:0046185)2.29355864
150protein maturation by protein folding (GO:0022417)2.28999278
151positive regulation of cellular amine metabolic process (GO:0033240)2.28966995
152response to peptidoglycan (GO:0032494)2.28426404
153prostate gland growth (GO:0060736)2.27891020
154membrane protein ectodomain proteolysis (GO:0006509)2.27318451
155vitamin biosynthetic process (GO:0009110)2.26293121
156ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.26117903
157intra-Golgi vesicle-mediated transport (GO:0006891)2.24938019
158glucosamine-containing compound catabolic process (GO:1901072)2.24598182
159piRNA metabolic process (GO:0034587)2.24485065
160glycosylceramide metabolic process (GO:0006677)2.24437746
161positive regulation of cardiac muscle hypertrophy (GO:0010613)2.23804480
162positive regulation of muscle hypertrophy (GO:0014742)2.23804480
163histone mRNA catabolic process (GO:0071044)2.23220342
164non-recombinational repair (GO:0000726)2.23081586
165double-strand break repair via nonhomologous end joining (GO:0006303)2.23081586
166regulation of cholesterol esterification (GO:0010872)2.23014150
167alpha-linolenic acid metabolic process (GO:0036109)2.22856322
168response to nitrosative stress (GO:0051409)2.22479187
169vitamin D metabolic process (GO:0042359)2.21874083
170protein targeting to Golgi (GO:0000042)2.21394378
171mitochondrial DNA replication (GO:0006264)2.21046509
172regulation of cofactor metabolic process (GO:0051193)2.20490245
173establishment of mitochondrion localization (GO:0051654)2.20371432
174ear development (GO:0043583)2.17854679
175negative regulation of protein localization to cell surface (GO:2000009)2.17618152
176negative regulation of axonogenesis (GO:0050771)2.17493603
177mammary gland alveolus development (GO:0060749)2.17469141
178negative regulation of execution phase of apoptosis (GO:1900118)2.16212236
179import into cell (GO:0098657)2.14350270
180nerve growth factor signaling pathway (GO:0038180)2.13014913
181zinc ion transmembrane transport (GO:0071577)2.12903854
182myelin assembly (GO:0032288)2.11807738
183acyl-CoA metabolic process (GO:0006637)2.10171908
184thioester metabolic process (GO:0035383)2.10171908
185negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.09946761
186peroxisome organization (GO:0007031)2.09321882
187Golgi to plasma membrane transport (GO:0006893)2.09204851
188Golgi to endosome transport (GO:0006895)2.09195166
189peptidyl-cysteine modification (GO:0018198)2.07714558
190retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.07593930
191regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.06930434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.19197995
2TAF15_26573619_Chip-Seq_HEK293_Human2.93043085
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77884223
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67350972
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63050165
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51059455
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43593344
8* ELK1_19687146_ChIP-ChIP_HELA_Human2.41668168
9GATA1_22025678_ChIP-Seq_K562_Human2.36480318
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23571786
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18921351
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17110888
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09645131
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07120891
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.00989813
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00650447
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00221984
18OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99100414
19VDR_22108803_ChIP-Seq_LS180_Human1.86303953
20AR_21909140_ChIP-Seq_LNCAP_Human1.86005159
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85424195
22NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85424195
23TFEB_21752829_ChIP-Seq_HELA_Human1.85241208
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83356525
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.81190578
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.80293070
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77368558
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72452508
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70593262
30EWS_26573619_Chip-Seq_HEK293_Human1.65492223
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64803293
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.62223874
33ER_23166858_ChIP-Seq_MCF-7_Human1.61667482
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57912874
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55854275
36P300_19829295_ChIP-Seq_ESCs_Human1.55733382
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55439029
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54558481
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53156899
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52561882
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52550139
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.52389810
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.51673529
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51069662
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.50971416
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50586527
47SMAD4_21799915_ChIP-Seq_A2780_Human1.49983274
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49246912
49STAT3_23295773_ChIP-Seq_U87_Human1.47311968
50FUS_26573619_Chip-Seq_HEK293_Human1.46563479
51IGF1R_20145208_ChIP-Seq_DFB_Human1.46248906
52VDR_23849224_ChIP-Seq_CD4+_Human1.45488059
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.43379613
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.42810654
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42660725
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42582777
57* IRF8_21731497_ChIP-ChIP_J774_Mouse1.42472487
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41975994
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.41700670
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.40792487
61* SALL4_22934838_ChIP-ChIP_CD34+_Human1.40093510
62AR_21572438_ChIP-Seq_LNCaP_Human1.38328624
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38318191
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38210371
65BRD4_25478319_ChIP-Seq_HGPS_Human1.38106277
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37527873
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33558589
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.31966774
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.31119937
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30974724
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30176485
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29997716
73TCF4_23295773_ChIP-Seq_U87_Human1.29459681
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27437910
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27344916
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27211089
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27141879
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.26654159
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26188628
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24953771
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24063449
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23552810
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23061268
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22766232
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22408279
86CDX2_22108803_ChIP-Seq_LS180_Human1.21674182
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20785845
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.20749335
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20505373
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.20424330
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19871669
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19089815
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18221795
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17517070
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15347413
96SPI1_23547873_ChIP-Seq_NB4_Human1.15336932
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15275904
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.15073187
99P53_22387025_ChIP-Seq_ESCs_Mouse1.14221403
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11920802
101P300_18555785_Chip-Seq_ESCs_Mouse1.11498050
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.10817120
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10248731
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10182191
105E2F7_22180533_ChIP-Seq_HELA_Human1.09562012
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.09345150
107FOXA1_25552417_ChIP-Seq_VCAP_Human1.08982202
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.08714530
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08620966
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07629078
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07490923
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.06650993
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06163799
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04944764
115ELF5_23300383_ChIP-Seq_T47D_Human1.04929178
116KDM2B_26808549_Chip-Seq_REH_Human1.04817902
117AR_25329375_ChIP-Seq_VCAP_Human1.04036673
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03953526
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.03831869
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.03735180
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03615416
122FOXP3_21729870_ChIP-Seq_TREG_Human1.03251141
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03194994
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03168161
125SOX2_20726797_ChIP-Seq_SW620_Human1.03161270
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.03100334
127PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02847214
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02711000
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02337763
130RUNX2_22187159_ChIP-Seq_PCA_Human1.02287229
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02146051
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01426301
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.01118081
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.99927083
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99642204
136GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98948258
137FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98937234
138TP53_18474530_ChIP-ChIP_U2OS_Human0.98453554
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98449178
140JUN_21703547_ChIP-Seq_K562_Human0.98309229
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.96666449
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96550475
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96470922
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96397662
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96013541
146NANOG_19829295_ChIP-Seq_ESCs_Human0.95953211
147SOX2_19829295_ChIP-Seq_ESCs_Human0.95953211
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95772328
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95107028
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94954170
151DCP1A_22483619_ChIP-Seq_HELA_Human0.94861808
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94128194
153NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93879377
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93757349
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93686505
156HTT_18923047_ChIP-ChIP_STHdh_Human0.93569242
157NMYC_18555785_Chip-Seq_ESCs_Mouse0.92867449
158BCAT_22108803_ChIP-Seq_LS180_Human0.92856016
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.92803962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.69515434
2MP0002139_abnormal_hepatobiliary_system3.52458921
3MP0003195_calcinosis3.48992583
4MP0003656_abnormal_erythrocyte_physiolo3.19509115
5MP0004270_analgesia2.95668405
6MP0000013_abnormal_adipose_tissue2.94831147
7MP0004043_abnormal_pH_regulation2.89948988
8MP0005365_abnormal_bile_salt2.82928541
9MP0005058_abnormal_lysosome_morphology2.68069579
10MP0009780_abnormal_chondrocyte_physiolo2.57712957
11MP0003300_gastrointestinal_ulcer2.52049603
12MP0010386_abnormal_urinary_bladder2.45087924
13MP0010352_gastrointestinal_tract_polyps2.40351406
14MP0005174_abnormal_tail_pigmentation2.38024476
15MP0008057_abnormal_DNA_replication2.37592014
16MP0000569_abnormal_digit_pigmentation2.31014126
17MP0003880_abnormal_central_pattern2.28360713
18MP0006054_spinal_hemorrhage2.25225406
19MP0003690_abnormal_glial_cell2.24321194
20MP0003329_amyloid_beta_deposits2.24057578
21MP0005085_abnormal_gallbladder_physiolo2.21015332
22MP0005360_urolithiasis2.20450591
23MP0003806_abnormal_nucleotide_metabolis2.07609029
24MP0008875_abnormal_xenobiotic_pharmacok2.05556956
25MP0005379_endocrine/exocrine_gland_phen2.02395542
26MP0001661_extended_life_span1.99484295
27MP0010234_abnormal_vibrissa_follicle1.93250435
28MP0003183_abnormal_peptide_metabolism1.89738485
29MP0001529_abnormal_vocalization1.76621280
30MP0002272_abnormal_nervous_system1.75245002
31MP0001905_abnormal_dopamine_level1.72641546
32MP0002837_dystrophic_cardiac_calcinosis1.71992461
33MP0002396_abnormal_hematopoietic_system1.69905623
34MP0000604_amyloidosis1.69435467
35MP0003186_abnormal_redox_activity1.69134040
36MP0005646_abnormal_pituitary_gland1.67047016
37MP0008004_abnormal_stomach_pH1.66100706
38MP0003724_increased_susceptibility_to1.64178713
39MP0009697_abnormal_copulation1.58579353
40MP0005464_abnormal_platelet_physiology1.58550327
41MP0004742_abnormal_vestibular_system1.58466065
42MP0002693_abnormal_pancreas_physiology1.55562107
43MP0000427_abnormal_hair_cycle1.55180851
44MP0000465_gastrointestinal_hemorrhage1.55014803
45MP0009840_abnormal_foam_cell1.54700085
46MP0003634_abnormal_glial_cell1.54012668
47MP0008058_abnormal_DNA_repair1.53414772
48MP0003632_abnormal_nervous_system1.53017910
49MP0002734_abnormal_mechanical_nocicepti1.48694014
50MP0005084_abnormal_gallbladder_morpholo1.48651453
51MP0005075_abnormal_melanosome_morpholog1.48562056
52MP0003828_pulmonary_edema1.47913702
53MP0005451_abnormal_body_composition1.47556730
54MP0002064_seizures1.45650208
55MP0003252_abnormal_bile_duct1.45404972
56MP0002229_neurodegeneration1.45327274
57MP0005332_abnormal_amino_acid1.42140822
58MP0004885_abnormal_endolymph1.41391314
59MP0001299_abnormal_eye_distance/1.39923579
60MP0000778_abnormal_nervous_system1.39745309
61MP0003950_abnormal_plasma_membrane1.38981316
62MP0001944_abnormal_pancreas_morphology1.37887434
63MP0006036_abnormal_mitochondrial_physio1.37593925
64MP0000003_abnormal_adipose_tissue1.37224701
65MP0001986_abnormal_taste_sensitivity1.37027028
66MP0001486_abnormal_startle_reflex1.33523915
67MP0000015_abnormal_ear_pigmentation1.33096552
68MP0005310_abnormal_salivary_gland1.29995261
69MP0005645_abnormal_hypothalamus_physiol1.29458434
70MP0002876_abnormal_thyroid_physiology1.29288016
71MP0003635_abnormal_synaptic_transmissio1.26360373
72MP0004859_abnormal_synaptic_plasticity1.25727278
73MP0010307_abnormal_tumor_latency1.25438668
74MP0009745_abnormal_behavioral_response1.25318539
75MP0008877_abnormal_DNA_methylation1.25280477
76MP0002572_abnormal_emotion/affect_behav1.25012529
77MP0001764_abnormal_homeostasis1.24602665
78MP0003631_nervous_system_phenotype1.22005619
79MP0003868_abnormal_feces_composition1.21038281
80MP0001346_abnormal_lacrimal_gland1.20644501
81MP0005171_absent_coat_pigmentation1.19130168
82MP0003633_abnormal_nervous_system1.18711100
83MP0000358_abnormal_cell_content/1.17284473
84MP0002118_abnormal_lipid_homeostasis1.17136568
85MP0004957_abnormal_blastocyst_morpholog1.16727195
86MP0005319_abnormal_enzyme/_coenzyme1.16388133
87MP0001485_abnormal_pinna_reflex1.15219741
88MP0005248_abnormal_Harderian_gland1.14992092
89MP0002132_abnormal_respiratory_system1.13953074
90MP0002063_abnormal_learning/memory/cond1.12109096
91MP0003221_abnormal_cardiomyocyte_apopto1.11250863
92MP0002078_abnormal_glucose_homeostasis1.10702406
93MP0002733_abnormal_thermal_nociception1.09315109
94MP0005220_abnormal_exocrine_pancreas1.08418128
95MP0000383_abnormal_hair_follicle1.07977437
96MP0001666_abnormal_nutrient_absorption1.07073580
97MP0002095_abnormal_skin_pigmentation1.06716849
98MP0000955_abnormal_spinal_cord1.06588096
99MP0001835_abnormal_antigen_presentation1.06435015
100MP0002877_abnormal_melanocyte_morpholog1.04384152
101MP0009046_muscle_twitch1.02964649
102MP0000371_diluted_coat_color1.02594270
103MP0000462_abnormal_digestive_system1.02489973
104MP0000609_abnormal_liver_physiology1.01831996
105MP0004808_abnormal_hematopoietic_stem1.01779874
106MP0001545_abnormal_hematopoietic_system1.01606120
107MP0005397_hematopoietic_system_phenotyp1.01606120
108MP0006082_CNS_inflammation1.01494954
109MP0003172_abnormal_lysosome_physiology1.00607811
110MP0001853_heart_inflammation1.00585056
111MP0002909_abnormal_adrenal_gland1.00572497
112MP0002138_abnormal_hepatobiliary_system1.00508565
113MP0001970_abnormal_pain_threshold0.99819856
114MP0004924_abnormal_behavior0.99614380
115MP0005386_behavior/neurological_phenoty0.99614380
116MP0002090_abnormal_vision0.99549487
117MP0001765_abnormal_ion_homeostasis0.99155698
118MP0005636_abnormal_mineral_homeostasis0.96511585
119MP0009785_altered_susceptibility_to0.96426403
120MP0005164_abnormal_response_to0.96255882
121MP0004019_abnormal_vitamin_homeostasis0.95999460
122MP0005535_abnormal_body_temperature0.95798407
123MP0005551_abnormal_eye_electrophysiolog0.95768864
124MP0005408_hypopigmentation0.95721576
125MP0004142_abnormal_muscle_tone0.95492876
126MP0004147_increased_porphyrin_level0.95046451
127MP0002419_abnormal_innate_immunity0.93559918
128MP0000343_altered_response_to0.92758781
129MP0003077_abnormal_cell_cycle0.92121615
130MP0000647_abnormal_sebaceous_gland0.91633530
131MP0004883_abnormal_blood_vessel0.91338179
132MP0003718_maternal_effect0.91188722
133MP0000538_abnormal_urinary_bladder0.90818261
134MP0009643_abnormal_urine_homeostasis0.90540364
135MP0000613_abnormal_salivary_gland0.90233703
136MP0005330_cardiomyopathy0.90088935
137MP0010678_abnormal_skin_adnexa0.89690282
138MP0003303_peritoneal_inflammation0.89673311
139MP0001502_abnormal_circadian_rhythm0.89555723
140MP0002166_altered_tumor_susceptibility0.89089917
141MP0002066_abnormal_motor_capabilities/c0.87307484
142MP0003941_abnormal_skin_development0.86538394
143MP0001845_abnormal_inflammatory_respons0.86303978
144MP0010329_abnormal_lipoprotein_level0.84829406
145MP0001177_atelectasis0.84712755
146MP0010094_abnormal_chromosome_stability0.84659753
147MP0006072_abnormal_retinal_apoptosis0.83212590
148MP0000516_abnormal_urinary_system0.83026632
149MP0005367_renal/urinary_system_phenotyp0.83026632
150MP0010155_abnormal_intestine_physiology0.81858236
151MP0008469_abnormal_protein_level0.81800367
152MP0008260_abnormal_autophagy0.81363475
153MP0006035_abnormal_mitochondrial_morpho0.81323891
154MP0002882_abnormal_neuron_morphology0.81038769
155MP0002067_abnormal_sensory_capabilities0.80980925
156MP0000639_abnormal_adrenal_gland0.80374580
157MP0008007_abnormal_cellular_replicative0.79356826
158MP0003011_delayed_dark_adaptation0.79142615
159MP0005275_abnormal_skin_tensile0.78716986
160MP0005376_homeostasis/metabolism_phenot0.78184278
161MP0000747_muscle_weakness0.77201813
162MP0002928_abnormal_bile_duct0.77056240
163MP0002163_abnormal_gland_morphology0.76902160
164MP0003448_altered_tumor_morphology0.74839904
165MP0005083_abnormal_biliary_tract0.73582893
166MP0003191_abnormal_cellular_cholesterol0.71032732
167MP0000230_abnormal_systemic_arterial0.69779269
168MP0006276_abnormal_autonomic_nervous0.68063142
169MP0001984_abnormal_olfaction0.67222254
170MP0002069_abnormal_eating/drinking_beha0.66948085
171MP0002938_white_spotting0.66840419

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.64053047
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.24501720
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.24501720
4Hypoglycemic seizures (HP:0002173)4.06601253
5Sensory axonal neuropathy (HP:0003390)3.99340350
6Symptomatic seizures (HP:0011145)3.88780259
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.81248253
8Conjugated hyperbilirubinemia (HP:0002908)3.69801991
9Hyperinsulinemic hypoglycemia (HP:0000825)3.67654759
10Intrahepatic cholestasis (HP:0001406)3.59845189
11Cerebral inclusion bodies (HP:0100314)3.43838012
12Abnormality of the corticospinal tract (HP:0002492)3.04034859
13Pancreatic islet-cell hyperplasia (HP:0004510)3.03336195
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.02392187
15Hypoglycemic coma (HP:0001325)3.02142832
16Metaphyseal dysplasia (HP:0100255)2.98977215
17Patchy hypopigmentation of hair (HP:0011365)2.97926442
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97254367
19Recurrent abscess formation (HP:0002722)2.94286413
20Parakeratosis (HP:0001036)2.82116945
21Agnosia (HP:0010524)2.80101972
22Osteolytic defects of the hand bones (HP:0009699)2.78749454
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.78749454
24Generalized aminoaciduria (HP:0002909)2.73226236
25Abnormality of liposaccharide metabolism (HP:0010968)2.72315449
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.72315449
27Abnormality of glycolipid metabolism (HP:0010969)2.72315449
28Thyroid carcinoma (HP:0002890)2.68649949
29Tubulointerstitial nephritis (HP:0001970)2.63631043
30Neoplasm of the small intestine (HP:0100833)2.63473765
31Spastic gait (HP:0002064)2.63236255
32Recurrent bacterial skin infections (HP:0005406)2.60422535
33Abnormality of fatty-acid metabolism (HP:0004359)2.60405048
34Hypomagnesemia (HP:0002917)2.55866265
35Abnormality of the pancreatic islet cells (HP:0006476)2.53381580
36Abnormality of endocrine pancreas physiology (HP:0012093)2.53381580
37Eczematoid dermatitis (HP:0000976)2.52460534
38Prolonged partial thromboplastin time (HP:0003645)2.52185106
39Volvulus (HP:0002580)2.52164869
40Hypophosphatemic rickets (HP:0004912)2.49831168
41Pheochromocytoma (HP:0002666)2.49058680
42Autoamputation (HP:0001218)2.48857042
43White forelock (HP:0002211)2.48279836
44Albinism (HP:0001022)2.47218938
45Disinhibition (HP:0000734)2.46480378
46Insidious onset (HP:0003587)2.45683323
47Termporal pattern (HP:0011008)2.45683323
48Rhabdomyosarcoma (HP:0002859)2.45291201
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44135471
50Fat malabsorption (HP:0002630)2.43220044
51Onion bulb formation (HP:0003383)2.42760870
52Abnormality of the intrinsic pathway (HP:0010989)2.40339635
53Hypoplasia of the uterus (HP:0000013)2.37632172
54Biliary tract neoplasm (HP:0100574)2.36174563
55Ketoacidosis (HP:0001993)2.35777146
56Intention tremor (HP:0002080)2.35070294
57Cerebral edema (HP:0002181)2.34699674
58Proximal tubulopathy (HP:0000114)2.32272894
59Abnormality of the common coagulation pathway (HP:0010990)2.31929720
60Hyperammonemia (HP:0001987)2.31924063
61Neuroendocrine neoplasm (HP:0100634)2.26927647
62Thickened helices (HP:0000391)2.26822713
63Progressive neurologic deterioration (HP:0002344)2.25523306
64Palpitations (HP:0001962)2.25045051
65Abnormality of vitamin B metabolism (HP:0004340)2.23387739
66Hyperglycemia (HP:0003074)2.20313045
67Hyperglycinemia (HP:0002154)2.19852779
68Hypsarrhythmia (HP:0002521)2.19244077
69Xanthomatosis (HP:0000991)2.19119589
70Increased circulating renin level (HP:0000848)2.17720978
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17235776
72Deep venous thrombosis (HP:0002625)2.16530609
73EEG with generalized epileptiform discharges (HP:0011198)2.15840915
74Akinesia (HP:0002304)2.15390816
75Mucosal telangiectasiae (HP:0100579)2.15057608
76Constricted visual fields (HP:0001133)2.14406125
77Supranuclear gaze palsy (HP:0000605)2.14278497
78Epileptiform EEG discharges (HP:0011182)2.14179539
79Renal cortical cysts (HP:0000803)2.12848580
80Neoplasm of the rectum (HP:0100743)2.11233292
81Hypobetalipoproteinemia (HP:0003563)2.11226328
82Large for gestational age (HP:0001520)2.10269407
83Nausea (HP:0002018)2.10121822
84Atonic seizures (HP:0010819)2.09450916
85Congenital ichthyosiform erythroderma (HP:0007431)2.09027838
86Abnormality of magnesium homeostasis (HP:0004921)2.08839804
87Abnormal spermatogenesis (HP:0008669)2.08148459
88Epileptic encephalopathy (HP:0200134)2.08008121
89Dysostosis multiplex (HP:0000943)2.05685205
90Dysmetria (HP:0001310)2.05558561
91Periodontitis (HP:0000704)2.04860109
92Hypokalemia (HP:0002900)2.04218191
93Loss of speech (HP:0002371)2.04163104
94Cerebral hemorrhage (HP:0001342)2.04122502
95Abnormality of serum amino acid levels (HP:0003112)2.04050355
96Peripheral hypomyelination (HP:0007182)2.03733575
97Conjunctival telangiectasia (HP:0000524)2.03416297
98Abnormality of methionine metabolism (HP:0010901)2.01065254
99Poor speech (HP:0002465)1.99928255
100Short nail (HP:0001799)1.96363385
101Ovarian neoplasm (HP:0100615)1.95493289
102Abnormality of macrophages (HP:0004311)1.95365411
103Hyperlipoproteinemia (HP:0010980)1.95192277
104Retinal dysplasia (HP:0007973)1.94536187
105Spastic paraparesis (HP:0002313)1.94417273
106Increased neuronal autofluorescent lipopigment (HP:0002074)1.94400049
107Abnormality of the vitamin B12 metabolism (HP:0004341)1.93425843
108Gingival bleeding (HP:0000225)1.93171713
109Steatorrhea (HP:0002570)1.92754694
110Protuberant abdomen (HP:0001538)1.91304762
111Conjunctival hamartoma (HP:0100780)1.90382159
112Hepatosplenomegaly (HP:0001433)1.89764083
113Abnormal biliary tract morphology (HP:0012440)1.89436829
114Degeneration of anterior horn cells (HP:0002398)1.87824710
115Abnormality of the anterior horn cell (HP:0006802)1.87824710
116Increased serum pyruvate (HP:0003542)1.87788297
117Increased CSF protein (HP:0002922)1.87487656
118Ketosis (HP:0001946)1.86916958
119Abnormality of serine family amino acid metabolism (HP:0010894)1.86491138
120Abnormality of glycine metabolism (HP:0010895)1.86491138
121Abnormality of the basal ganglia (HP:0002134)1.86332615
122Hypokalemic alkalosis (HP:0001949)1.85590089
123Medulloblastoma (HP:0002885)1.85090454
124Abnormal drinking behavior (HP:0030082)1.85069386
125Polydipsia (HP:0001959)1.85069386
126Insulin-resistant diabetes mellitus (HP:0000831)1.84685519
127Petechiae (HP:0000967)1.83956858
128Hyperphosphatemia (HP:0002905)1.83732272
129Focal motor seizures (HP:0011153)1.83395337
130Anteriorly placed anus (HP:0001545)1.83376115
131Hyperventilation (HP:0002883)1.83183487
132Slow saccadic eye movements (HP:0000514)1.83131316
133Clumsiness (HP:0002312)1.82601480
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82146565
135Abnormality of potassium homeostasis (HP:0011042)1.80055358
136Acute hepatic failure (HP:0006554)1.79876294
137Abnormality of urine glucose concentration (HP:0011016)1.79808768
138Glycosuria (HP:0003076)1.79808768
139Cone-rod dystrophy (HP:0000548)1.79151695
140Abnormality of chromosome stability (HP:0003220)1.78895972
141Azoospermia (HP:0000027)1.78104858
142Papillary thyroid carcinoma (HP:0002895)1.77758732
143Generalized myoclonic seizures (HP:0002123)1.77663643
144Lower limb hyperreflexia (HP:0002395)1.77466096
145Hypothermia (HP:0002045)1.77370953
146Type II lissencephaly (HP:0007260)1.76341768
147Acute encephalopathy (HP:0006846)1.75920061
148Sensorimotor neuropathy (HP:0007141)1.75913881
149Erythroderma (HP:0001019)1.75157361
150Choroideremia (HP:0001139)1.74501265
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.73109620
152Metabolic acidosis (HP:0001942)1.72441330
153Infantile muscular hypotonia (HP:0008947)1.71987534
154Pancreatitis (HP:0001733)1.71894561
155Megaloblastic anemia (HP:0001889)1.71126256
156Spastic tetraparesis (HP:0001285)1.68420519
157Clonus (HP:0002169)1.68149518
158Megalencephaly (HP:0001355)1.66953914
159Cutaneous melanoma (HP:0012056)1.65979151
160Hypolipoproteinemia (HP:0010981)1.65784473
161Recurrent skin infections (HP:0001581)1.65542462
162Orthostatic hypotension (HP:0001278)1.65424800
163Increased cerebral lipofuscin (HP:0011813)1.65037912
164Abnormality of vitamin metabolism (HP:0100508)1.64701102
165Lethargy (HP:0001254)1.64255689
166Exocrine pancreatic insufficiency (HP:0001738)1.64152268
167Postural tremor (HP:0002174)1.64109548
168Choreoathetosis (HP:0001266)1.63899350
169Metaphyseal irregularity (HP:0003025)1.63154473
170Vacuolated lymphocytes (HP:0001922)1.62526448
171Hyperglycinuria (HP:0003108)1.62229361
172Stridor (HP:0010307)1.61533802
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60946952
174Abnormal gallbladder morphology (HP:0012437)1.60677248
175Progressive macrocephaly (HP:0004481)1.58808485
176Osteomyelitis (HP:0002754)1.58180621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.26747767
2INSRR3.54354159
3OXSR13.41486262
4NEK93.02456379
5ERBB32.97336080
6MAP3K122.88133811
7ACVR1B2.79514338
8BCR2.77101159
9BCKDK2.72877310
10WNK42.70871259
11FRK2.33502474
12STK242.24788227
13ERBB42.20150922
14EPHB12.19508004
15PRPF4B2.06047371
16EIF2AK12.04301778
17STK38L1.95124943
18CASK1.94710595
19MET1.92452814
20TAOK31.91033194
21MAP3K21.85447818
22MAP3K131.84883231
23TYK21.75233100
24WNK11.69610476
25STK31.68698005
26NTRK11.67554609
27MAPK151.64895829
28NEK11.59293007
29SGK4941.58531622
30SGK2231.58531622
31PKN11.57656805
32CDK191.56300485
33PDK21.54067972
34FGFR21.53846086
35CCNB11.48659519
36BRSK21.47889859
37NEK61.46448244
38YES11.44051774
39PAK31.41311363
40TSSK61.37164318
41MST41.36847981
42CSNK1A1L1.36837230
43BMPR21.27856510
44TRIM281.26551545
45AKT31.25401800
46MAP4K21.23090264
47NTRK31.21246708
48ADRBK21.20335519
49TNIK1.18862575
50CAMK2B1.18083348
51MAPKAPK51.17888738
52SCYL21.16142689
53TAF11.16123641
54BMPR1B1.15934532
55MYLK1.14792011
56IRAK21.12866005
57CSNK1G31.12274793
58MAP3K141.12051530
59ARAF1.11441825
60BRAF1.11316102
61UHMK11.09310843
62NUAK11.08483146
63KSR21.06515287
64TTK1.04683196
65MAP3K41.04563166
66HIPK21.01814499
67PBK1.01414214
68EIF2AK20.99870258
69PRKCQ0.99467033
70CSNK1G20.98595966
71IRAK10.98249658
72CAMK2D0.94762213
73BLK0.94388950
74ITK0.93760660
75MAP2K30.93057448
76FGR0.91349138
77MST1R0.90214942
78CDK50.90065922
79TGFBR20.89876709
80PINK10.89861039
81STK100.89614816
82CSNK1G10.89309448
83PRKCE0.88764045
84RPS6KA40.87501351
85PAK60.86334628
86LIMK10.85822460
87JAK10.85458080
88STK40.84507548
89PNCK0.83797168
90CAMK2A0.83176821
91PDPK10.82620783
92PRKG20.82409945
93WNK30.81943659
94EPHA40.81541390
95LMTK20.81235122
96ROCK20.79884716
97CSF1R0.78032609
98PIK3CG0.77982082
99PRKCH0.77454935
100PLK30.75237812
101SGK20.73209191
102CAMKK20.72314123
103PLK40.70083464
104CDK60.69580438
105ICK0.67381501
106CAMK2G0.66405904
107TEC0.65018681
108GRK70.64970839
109DMPK0.64628775
110MELK0.64366387
111RIPK40.63466187
112MAP2K70.62438067
113NLK0.61786269
114RET0.59930536
115VRK10.59347926
116PDK10.59001704
117LRRK20.57097333
118MAP3K10.55849461
119TGFBR10.55774953
120CDK140.55758282
121STK160.55384962
122KSR10.55141482
123FGFR30.54234001
124BUB10.54114110
125DYRK30.54097138
126PASK0.53408407
127SGK10.53199901
128PTK20.52900752
129MOS0.52269544
130PRKG10.52007865
131MKNK10.51460137
132NME20.50422849
133MAP3K90.50096476
134MARK20.49234384
135ABL10.48870652
136PLK20.48866803
137GRK10.48347845
138WEE10.46110291
139FER0.44827034
140PRKD10.44826937
141TRPM70.44777310
142EGFR0.43955282
143EPHA30.43831083
144TXK0.43269442
145MATK0.42115338
146EIF2AK30.41909852
147HCK0.41714332
148RAF10.41524955
149CSNK1A10.40715031
150MAP2K40.40516793
151CSK0.39366617
152GSK3A0.39214066
153JAK20.38964015
154PAK40.37440557
155IKBKB0.36730638
156INSR0.36596072
157GRK50.36452679
158FYN0.36164971
159ATM0.35794046
160CDK180.35753316
161SGK30.34741926
162MAP3K80.34669902
163PRKAA20.31552476
164CDK80.31470330
165ZAK0.30026687
166LYN0.29587431

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.69576076
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.45235245
3Steroid biosynthesis_Homo sapiens_hsa001003.36838738
4Protein export_Homo sapiens_hsa030603.18015172
5Sulfur metabolism_Homo sapiens_hsa009203.10480385
6Fatty acid elongation_Homo sapiens_hsa000622.83985070
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.70501622
8Non-homologous end-joining_Homo sapiens_hsa034502.39354093
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09991293
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03838473
11Mismatch repair_Homo sapiens_hsa034302.02094391
12Butanoate metabolism_Homo sapiens_hsa006501.98603810
13Pyruvate metabolism_Homo sapiens_hsa006201.70645489
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.69193936
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65439030
16Histidine metabolism_Homo sapiens_hsa003401.63970210
17Legionellosis_Homo sapiens_hsa051341.63580409
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61733292
19Ether lipid metabolism_Homo sapiens_hsa005651.54513392
20Vibrio cholerae infection_Homo sapiens_hsa051101.51251020
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47366025
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44821490
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39312692
24Carbon metabolism_Homo sapiens_hsa012001.37866274
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34562477
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34027384
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29538631
28Nucleotide excision repair_Homo sapiens_hsa034201.27059007
29Collecting duct acid secretion_Homo sapiens_hsa049661.25570375
30Sphingolipid metabolism_Homo sapiens_hsa006001.24964720
31Proteasome_Homo sapiens_hsa030501.21474316
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20230237
33Tryptophan metabolism_Homo sapiens_hsa003801.19283300
34Glutathione metabolism_Homo sapiens_hsa004801.15738315
35Insulin secretion_Homo sapiens_hsa049111.13641595
36Peroxisome_Homo sapiens_hsa041461.13063493
37Basal transcription factors_Homo sapiens_hsa030221.13013241
38Lysosome_Homo sapiens_hsa041421.12002606
39Fatty acid metabolism_Homo sapiens_hsa012121.10784196
40Serotonergic synapse_Homo sapiens_hsa047261.10419664
41GABAergic synapse_Homo sapiens_hsa047271.05986728
42Propanoate metabolism_Homo sapiens_hsa006401.04726620
43Vitamin B6 metabolism_Homo sapiens_hsa007501.01629526
44Rheumatoid arthritis_Homo sapiens_hsa053231.01384891
45Type I diabetes mellitus_Homo sapiens_hsa049400.99398689
46Renin-angiotensin system_Homo sapiens_hsa046140.99186418
47Cocaine addiction_Homo sapiens_hsa050300.97932731
48* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97886328
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96853339
50Mineral absorption_Homo sapiens_hsa049780.92168625
51Leishmaniasis_Homo sapiens_hsa051400.91855232
52Complement and coagulation cascades_Homo sapiens_hsa046100.90607633
53Selenocompound metabolism_Homo sapiens_hsa004500.90027318
54Synaptic vesicle cycle_Homo sapiens_hsa047210.89317258
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.89273374
56Nitrogen metabolism_Homo sapiens_hsa009100.88455483
57ABC transporters_Homo sapiens_hsa020100.87853286
58Type II diabetes mellitus_Homo sapiens_hsa049300.87619288
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86957007
60Vitamin digestion and absorption_Homo sapiens_hsa049770.86731539
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86345265
62Axon guidance_Homo sapiens_hsa043600.86042660
63Morphine addiction_Homo sapiens_hsa050320.84507416
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.83380857
65Fatty acid degradation_Homo sapiens_hsa000710.82394576
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.82072396
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80947053
68Chemical carcinogenesis_Homo sapiens_hsa052040.80839859
69Phagosome_Homo sapiens_hsa041450.80038283
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79896877
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79741724
72Arginine and proline metabolism_Homo sapiens_hsa003300.79506737
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78589034
74Glutamatergic synapse_Homo sapiens_hsa047240.78148793
75Linoleic acid metabolism_Homo sapiens_hsa005910.77942575
76One carbon pool by folate_Homo sapiens_hsa006700.76920929
77Long-term depression_Homo sapiens_hsa047300.76595861
78Arginine biosynthesis_Homo sapiens_hsa002200.73622857
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73577496
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73501628
81Dopaminergic synapse_Homo sapiens_hsa047280.72293276
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72277051
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70456749
84Pentose phosphate pathway_Homo sapiens_hsa000300.69468130
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67979094
86Tyrosine metabolism_Homo sapiens_hsa003500.67141465
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66001319
88Renal cell carcinoma_Homo sapiens_hsa052110.65941413
89Prion diseases_Homo sapiens_hsa050200.65014533
90Starch and sucrose metabolism_Homo sapiens_hsa005000.64957696
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63892913
92Galactose metabolism_Homo sapiens_hsa000520.63532194
93Cholinergic synapse_Homo sapiens_hsa047250.62908866
94Measles_Homo sapiens_hsa051620.60940037
95Ovarian steroidogenesis_Homo sapiens_hsa049130.60731495
96Staphylococcus aureus infection_Homo sapiens_hsa051500.59858722
97* Metabolic pathways_Homo sapiens_hsa011000.59496695
98Regulation of autophagy_Homo sapiens_hsa041400.59326671
99Oxidative phosphorylation_Homo sapiens_hsa001900.56811067
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56132219
101Retinol metabolism_Homo sapiens_hsa008300.56113766
102Phenylalanine metabolism_Homo sapiens_hsa003600.56015640
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.55949007
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52915650
105Taste transduction_Homo sapiens_hsa047420.52605031
106Fanconi anemia pathway_Homo sapiens_hsa034600.52181863
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51779476
108Circadian rhythm_Homo sapiens_hsa047100.51727154
109Tuberculosis_Homo sapiens_hsa051520.51664932
110Amphetamine addiction_Homo sapiens_hsa050310.50929772
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50903155
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.50337322
113Arachidonic acid metabolism_Homo sapiens_hsa005900.49717923
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49626848
115PPAR signaling pathway_Homo sapiens_hsa033200.48675893
116Sulfur relay system_Homo sapiens_hsa041220.48352102
117Autoimmune thyroid disease_Homo sapiens_hsa053200.48283530
118Folate biosynthesis_Homo sapiens_hsa007900.47829490
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47517525
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47436528
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46958054
122Malaria_Homo sapiens_hsa051440.46195641
123Circadian entrainment_Homo sapiens_hsa047130.46139194
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45826299
125Bile secretion_Homo sapiens_hsa049760.45714190
126Caffeine metabolism_Homo sapiens_hsa002320.44178603
127N-Glycan biosynthesis_Homo sapiens_hsa005100.44138675
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43924638
129beta-Alanine metabolism_Homo sapiens_hsa004100.43459486
130Homologous recombination_Homo sapiens_hsa034400.43264821
131Ras signaling pathway_Homo sapiens_hsa040140.40948579
132DNA replication_Homo sapiens_hsa030300.40154919
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40046087
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.39591054
135p53 signaling pathway_Homo sapiens_hsa041150.38406246
136Base excision repair_Homo sapiens_hsa034100.37865014
137ErbB signaling pathway_Homo sapiens_hsa040120.37143107
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37066892
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36485162
140Toxoplasmosis_Homo sapiens_hsa051450.36330811
141Parkinsons disease_Homo sapiens_hsa050120.36162837
142Osteoclast differentiation_Homo sapiens_hsa043800.36007512
143Long-term potentiation_Homo sapiens_hsa047200.34999200
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33645072
145African trypanosomiasis_Homo sapiens_hsa051430.33549844
146Other glycan degradation_Homo sapiens_hsa005110.33278672
147Pancreatic secretion_Homo sapiens_hsa049720.33091579
148Choline metabolism in cancer_Homo sapiens_hsa052310.31934103
149Endocytosis_Homo sapiens_hsa041440.31848428
150Glycerolipid metabolism_Homo sapiens_hsa005610.31398677
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30848857

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