FPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.97497357
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.71913442
3negative regulation of cell killing (GO:0031342)6.71913442
4modulation by symbiont of host immune response (GO:0052553)6.65689084
5positive regulation by symbiont of host defense response (GO:0052509)6.65689084
6modulation by symbiont of host defense response (GO:0052031)6.65689084
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.65689084
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.65689084
9positive regulation by organism of defense response of other organism involved in symbiotic interact6.65689084
10neutrophil activation involved in immune response (GO:0002283)6.34391950
11hydrogen peroxide biosynthetic process (GO:0050665)6.23466431
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.92838194
13positive regulation of chemokine biosynthetic process (GO:0045080)5.78209506
14antigen processing and presentation of endogenous antigen (GO:0019883)5.74528444
15positive regulation of gamma-delta T cell activation (GO:0046645)5.62363070
16reactive oxygen species biosynthetic process (GO:1903409)5.53639060
17respiratory burst (GO:0045730)5.46917304
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.32862917
19lipopolysaccharide-mediated signaling pathway (GO:0031663)5.31488771
20positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.17881248
21leukocyte aggregation (GO:0070486)5.11898421
22superoxide anion generation (GO:0042554)5.10760371
23leukocyte migration involved in inflammatory response (GO:0002523)5.05763076
24macrophage activation involved in immune response (GO:0002281)5.00017668
25granulocyte activation (GO:0036230)4.93056897
26regulation of B cell receptor signaling pathway (GO:0050855)4.89778356
27regulation of chemokine biosynthetic process (GO:0045073)4.86718164
28response to host immune response (GO:0052572)4.81345308
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.81345308
30positive regulation of heat generation (GO:0031652)4.64102880
31regulation of fever generation (GO:0031620)4.60511888
32production of molecular mediator involved in inflammatory response (GO:0002532)4.58127777
33neutrophil activation (GO:0042119)4.54796102
34negative regulation of lymphocyte mediated immunity (GO:0002707)4.54289668
35detection of molecule of bacterial origin (GO:0032490)4.46872484
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.45974726
37response to interleukin-15 (GO:0070672)4.44037019
38positive regulation of mast cell degranulation (GO:0043306)4.42344634
39positive regulation of mast cell activation involved in immune response (GO:0033008)4.42344634
40detection of other organism (GO:0098543)4.35944790
41response to host (GO:0075136)4.31022797
42response to host defenses (GO:0052200)4.31022797
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.31022797
44immunoglobulin mediated immune response (GO:0016064)4.22468230
45negative regulation of interleukin-12 production (GO:0032695)4.19670590
46detection of external biotic stimulus (GO:0098581)4.19542292
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16520378
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14235588
49regulation of podosome assembly (GO:0071801)4.11591684
50detection of bacterium (GO:0016045)4.09358966
51cellular response to interleukin-15 (GO:0071350)4.08700354
52positive regulation of mast cell activation (GO:0033005)4.07834631
53regulation of gamma-delta T cell activation (GO:0046643)4.05721612
54positive regulation of cellular amide metabolic process (GO:0034250)4.04193406
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.97880782
56negative regulation of leukocyte mediated immunity (GO:0002704)3.96886180
57myeloid cell activation involved in immune response (GO:0002275)3.90664515
58regulation of heterotypic cell-cell adhesion (GO:0034114)3.88525995
59neutrophil mediated immunity (GO:0002446)3.81515768
60microglial cell activation (GO:0001774)3.81204737
61positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.71591728
62cellular extravasation (GO:0045123)3.69005377
63neutrophil chemotaxis (GO:0030593)3.68640636
64detection of biotic stimulus (GO:0009595)3.67101330
65regulation of vitamin D biosynthetic process (GO:0060556)3.66196037
66negative regulation of T cell mediated immunity (GO:0002710)3.66073412
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64600134
68type I interferon signaling pathway (GO:0060337)3.62641308
69cellular response to type I interferon (GO:0071357)3.62641308
70regulation of mast cell degranulation (GO:0043304)3.60893870
71antigen processing and presentation via MHC class Ib (GO:0002475)3.59703758
72positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.59687463
73response to type I interferon (GO:0034340)3.59462259
74neutrophil migration (GO:1990266)3.58668153
75macrophage activation (GO:0042116)3.56883859
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56010681
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.55758399
78regulation of heat generation (GO:0031650)3.55591727
79T-helper 1 type immune response (GO:0042088)3.54177424
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.52745665
81myeloid leukocyte mediated immunity (GO:0002444)3.48799667
82positive regulation of interferon-alpha production (GO:0032727)3.47751965
83regulation of gamma-delta T cell differentiation (GO:0045586)3.45949299
84regulation of mast cell activation (GO:0033003)3.43215634
85negative regulation of phagocytosis (GO:0050765)3.39627015
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39055644
87regulation of T cell tolerance induction (GO:0002664)3.38652190
88regulation of leukocyte degranulation (GO:0043300)3.37891749
89regulation of mast cell activation involved in immune response (GO:0033006)3.37265093
90positive regulation of leukocyte degranulation (GO:0043302)3.35185594
91regulation of tolerance induction (GO:0002643)3.33327343
92regulation of interferon-alpha production (GO:0032647)3.30804601
93B cell receptor signaling pathway (GO:0050853)3.28708538
94germinal center formation (GO:0002467)3.28626989
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.28584948
96negative regulation of myeloid cell apoptotic process (GO:0033033)3.27691996
97regulation of T-helper 2 cell differentiation (GO:0045628)3.26479861
98regulation of vitamin metabolic process (GO:0030656)3.22634573
99granulocyte chemotaxis (GO:0071621)3.22587773
100regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.22579424
101positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.22461370
102negative regulation of interleukin-17 production (GO:0032700)3.21969155
103positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.21369365
104negative regulation of T-helper cell differentiation (GO:0045623)3.20859344
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.20859344
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.20023363
107dendritic cell migration (GO:0036336)3.19957214
108granulocyte migration (GO:0097530)3.17734047
109positive regulation of NF-kappaB import into nucleus (GO:0042346)3.17363977
110leukocyte mediated cytotoxicity (GO:0001909)3.17150375
111positive regulation of interleukin-6 production (GO:0032755)3.16814544
112regulation of T cell mediated cytotoxicity (GO:0001914)3.16626251
113positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16605643
114phagosome maturation (GO:0090382)3.16414365
115interferon-gamma-mediated signaling pathway (GO:0060333)3.16159466
116response to muramyl dipeptide (GO:0032495)3.15976297
117dendritic cell chemotaxis (GO:0002407)3.14576416
118positive regulation of chemokine production (GO:0032722)3.13309533
119regulation of B cell differentiation (GO:0045577)3.12763507
120B cell mediated immunity (GO:0019724)3.12510986
121regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.11685512
122regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.09970568
123eosinophil migration (GO:0072677)3.08327964
124positive regulation of acute inflammatory response (GO:0002675)3.07672745
125positive regulation of toll-like receptor signaling pathway (GO:0034123)3.07425907
126regulation of interleukin-8 biosynthetic process (GO:0045414)3.07180342
127negative regulation of type 2 immune response (GO:0002829)3.05526511
128leukocyte degranulation (GO:0043299)3.05096155
129chronic inflammatory response (GO:0002544)3.04854293
130regulation of regulated secretory pathway (GO:1903305)3.03842629
131regulation of interferon-beta biosynthetic process (GO:0045357)3.02898678
132defense response to protozoan (GO:0042832)3.02867795
133cytokine secretion (GO:0050663)3.02612102
134negative regulation of interleukin-6 production (GO:0032715)3.01382081
135negative regulation of lipid storage (GO:0010888)3.00383459
136positive regulation of nitric oxide biosynthetic process (GO:0045429)3.00379439
137negative regulation of growth of symbiont in host (GO:0044130)2.98325452
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.98325452
139modulation of growth of symbiont involved in interaction with host (GO:0044144)2.98325452
140regulation of growth of symbiont in host (GO:0044126)2.98325452
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97545110
142negative regulation of innate immune response (GO:0045824)2.97356028
143negative regulation of alpha-beta T cell activation (GO:0046636)2.97085173
144negative regulation of amino acid transport (GO:0051956)2.97031108
145regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.96108700
146regulation of natural killer cell mediated immunity (GO:0002715)2.96108700
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95944946
148negative regulation of cytokine production involved in immune response (GO:0002719)2.95140138
149myeloid leukocyte activation (GO:0002274)2.95128808
150positive regulation of humoral immune response (GO:0002922)2.94198846
151regulation of mononuclear cell migration (GO:0071675)2.92540723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.19218313
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.93906853
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.63983905
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.29330296
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.93088824
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.67225708
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62697254
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.51741055
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51404706
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28817653
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.26667179
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.19301992
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.05551114
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74733599
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63939549
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34544864
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31551901
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25344595
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17861930
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16729343
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16174652
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.00544305
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96173833
24MYC_22102868_ChIP-Seq_BL_Human1.93808166
25TCF7_22412390_ChIP-Seq_EML_Mouse1.92276223
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91742827
27SPI1_23547873_ChIP-Seq_NB4_Human1.90912830
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85468387
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83876275
30VDR_24787735_ChIP-Seq_THP-1_Human1.79037936
31MAF_26560356_Chip-Seq_TH2_Human1.75550647
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70606208
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70465295
34KDM2B_26808549_Chip-Seq_DND41_Human1.67942954
35VDR_24763502_ChIP-Seq_THP-1_Human1.61813433
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58717847
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55991573
38PU_27001747_Chip-Seq_BMDM_Mouse1.55044214
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54005737
40RUNX_20019798_ChIP-Seq_JUKART_Human1.50914940
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49403025
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45998837
43SPI1_23127762_ChIP-Seq_K562_Human1.44162997
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43853476
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43626746
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40446071
47CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37000413
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.34267444
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31297727
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30593873
51MYB_26560356_Chip-Seq_TH2_Human1.30281171
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30003712
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28784945
54SCL_19346495_ChIP-Seq_HPC-7_Human1.27201653
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.27068211
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26553823
57SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22323742
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21771478
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21684385
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20800197
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19653258
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18602796
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15823533
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15593328
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15483962
66LXR_22292898_ChIP-Seq_THP-1_Human1.14788459
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14545702
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.14053717
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12858936
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.11620704
71GATA3_26560356_Chip-Seq_TH2_Human1.09962447
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09322252
73BCL6_27268052_Chip-Seq_Bcells_Human1.08499046
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08014133
75GATA1_22025678_ChIP-Seq_K562_Human1.07775707
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07663047
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06995892
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06872966
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06182087
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05596241
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05596241
82MAF_26560356_Chip-Seq_TH1_Human0.99785573
83BCOR_27268052_Chip-Seq_Bcells_Human0.99657405
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98129397
85GATA3_27048872_Chip-Seq_THYMUS_Human0.97551784
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95894652
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93913322
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93767539
89SPI1_20517297_ChIP-Seq_HL60_Human0.93663604
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92858490
91MYB_26560356_Chip-Seq_TH1_Human0.92808449
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92684521
93EGR1_19032775_ChIP-ChIP_M12_Human0.92481390
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92414244
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91136543
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88385536
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87885158
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87818773
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.86593447
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85674905
101CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84867551
102SOX2_20726797_ChIP-Seq_SW620_Human0.83823403
103UTX_26944678_Chip-Seq_JUKART_Human0.83414914
104NCOR1_26117541_ChIP-Seq_K562_Human0.82715743
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82454862
106GATA2_19941826_ChIP-Seq_K562_Human0.82318049
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82158917
108GATA1_19941826_ChIP-Seq_K562_Human0.81453530
109RXR_22158963_ChIP-Seq_LIVER_Mouse0.80434956
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77875293
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76193553
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75550594
113TRIM28_21343339_ChIP-Seq_HEK293_Human0.74850999
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.73684871
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73607311
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72944823
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69659240
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.66934350
119PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66874731
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.65621097
121VDR_21846776_ChIP-Seq_THP-1_Human0.62816184
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62645507
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.61848815
124RXR_22108803_ChIP-Seq_LS180_Human0.60175057
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58464802
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57483577
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.56578830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.64304288
2MP0003436_decreased_susceptibility_to4.45654685
3* MP0009785_altered_susceptibility_to4.18521352
4* MP0002419_abnormal_innate_immunity3.64135450
5MP0002148_abnormal_hypersensitivity_rea3.53705653
6MP0001835_abnormal_antigen_presentation3.44007100
7MP0006082_CNS_inflammation3.19980582
8MP0003303_peritoneal_inflammation3.16962264
9MP0005000_abnormal_immune_tolerance3.10903217
10* MP0005025_abnormal_response_to3.08764151
11MP0009278_abnormal_bone_marrow3.01099465
12MP0005058_abnormal_lysosome_morphology2.90112960
13MP0009764_decreased_sensitivity_to2.77183505
14MP0005167_abnormal_blood-brain_barrier2.71922275
15MP0001533_abnormal_skeleton_physiology2.52708697
16MP0002452_abnormal_antigen_presenting2.50459702
17MP0002723_abnormal_immune_serum2.37559384
18MP0005387_immune_system_phenotype2.32695114
19MP0001790_abnormal_immune_system2.32695114
20MP0005464_abnormal_platelet_physiology2.28230456
21MP0001800_abnormal_humoral_immune2.27032077
22MP0003075_altered_response_to2.26637761
23MP0003195_calcinosis2.25434757
24MP0002132_abnormal_respiratory_system2.17766798
25MP0004947_skin_inflammation2.13275306
26MP0004510_myositis2.11237287
27MP0000685_abnormal_immune_system2.09940301
28MP0003191_abnormal_cellular_cholesterol2.08277754
29MP0001845_abnormal_inflammatory_respons2.06599256
30* MP0001819_abnormal_immune_cell2.06005164
31* MP0002420_abnormal_adaptive_immunity2.04142833
32MP0003763_abnormal_thymus_physiology1.95122688
33MP0000343_altered_response_to1.89587147
34MP0002405_respiratory_system_inflammati1.87650460
35MP0008469_abnormal_protein_level1.85342514
36MP0003172_abnormal_lysosome_physiology1.80924015
37MP0002006_tumorigenesis1.79767997
38MP0005671_abnormal_response_to1.74985086
39MP0000858_altered_metastatic_potential1.71298114
40MP0000465_gastrointestinal_hemorrhage1.70773979
41MP0002277_abnormal_respiratory_mucosa1.70085371
42MP0003866_abnormal_defecation1.65454815
43MP0002396_abnormal_hematopoietic_system1.64674811
44MP0002998_abnormal_bone_remodeling1.55986197
45MP0003448_altered_tumor_morphology1.55572936
46MP0005166_decreased_susceptibility_to1.55145660
47MP0001853_heart_inflammation1.54606100
48MP0003186_abnormal_redox_activity1.54053138
49MP0004381_abnormal_hair_follicle1.47728028
50MP0003183_abnormal_peptide_metabolism1.45780478
51MP0005164_abnormal_response_to1.44076142
52MP0001545_abnormal_hematopoietic_system1.43060264
53MP0005397_hematopoietic_system_phenotyp1.43060264
54MP0000703_abnormal_thymus_morphology1.38391558
55MP0003828_pulmonary_edema1.37066034
56MP0008260_abnormal_autophagy1.36336846
57MP0003646_muscle_fatigue1.34088983
58MP0010155_abnormal_intestine_physiology1.31788689
59MP0000716_abnormal_immune_system1.29712415
60MP0002332_abnormal_exercise_endurance1.26235538
61MP0002933_joint_inflammation1.25602419
62MP0009840_abnormal_foam_cell1.23759485
63MP0005390_skeleton_phenotype1.17893378
64MP0009763_increased_sensitivity_to1.11627094
65MP0005310_abnormal_salivary_gland1.11389191
66MP0002398_abnormal_bone_marrow1.09022705
67MP0005451_abnormal_body_composition1.07203339
68MP0005076_abnormal_cell_differentiation1.06158796
69MP0000604_amyloidosis1.02247816
70MP0002429_abnormal_blood_cell1.00657335
71MP0003453_abnormal_keratinocyte_physiol1.00437807
72MP0004883_abnormal_blood_vessel0.99384400
73MP0009333_abnormal_splenocyte_physiolog0.97688973
74MP0005083_abnormal_biliary_tract0.95744799
75MP0004782_abnormal_surfactant_physiolog0.95209506
76MP0000689_abnormal_spleen_morphology0.93005099
77MP0001851_eye_inflammation0.90492981
78MP0008004_abnormal_stomach_pH0.89446301
79MP0000569_abnormal_digit_pigmentation0.86033125
80MP0003656_abnormal_erythrocyte_physiolo0.85915368
81MP0001958_emphysema0.84953615
82MP0003690_abnormal_glial_cell0.84112903
83MP0003045_fibrosis0.82702194
84MP0001663_abnormal_digestive_system0.82358780
85MP0002722_abnormal_immune_system0.81409256
86MP0001501_abnormal_sleep_pattern0.80637978
87MP0003806_abnormal_nucleotide_metabolis0.78637695
88MP0005075_abnormal_melanosome_morpholog0.77754111
89MP0001986_abnormal_taste_sensitivity0.76405064
90MP0000490_abnormal_crypts_of0.76062390
91MP0005535_abnormal_body_temperature0.74737605
92MP0000249_abnormal_blood_vessel0.74501107
93MP0004858_abnormal_nervous_system0.72465548
94MP0000920_abnormal_myelination0.68978065
95MP0002138_abnormal_hepatobiliary_system0.68016526
96MP0003878_abnormal_ear_physiology0.67797009
97MP0005377_hearing/vestibular/ear_phenot0.67797009
98MP0003221_abnormal_cardiomyocyte_apopto0.67596496
99MP0001873_stomach_inflammation0.67454825
100MP0009765_abnormal_xenobiotic_induced0.66588885
101MP0008874_decreased_physiological_sensi0.65846516
102MP0003795_abnormal_bone_structure0.64101891
103MP0004808_abnormal_hematopoietic_stem0.63503439
104MP0005319_abnormal_enzyme/_coenzyme0.62974451
105MP0005584_abnormal_enzyme/coenzyme_acti0.62500797
106MP0000015_abnormal_ear_pigmentation0.62486383
107MP0008873_increased_physiological_sensi0.60639899
108MP0000371_diluted_coat_color0.60435807
109MP0002928_abnormal_bile_duct0.60376859
110MP0005248_abnormal_Harderian_gland0.59053149
111MP0002254_reproductive_system_inflammat0.58248704
112MP0002133_abnormal_respiratory_system0.57849202
113MP0005388_respiratory_system_phenotype0.57849202
114MP0003300_gastrointestinal_ulcer0.57190538
115MP0005165_increased_susceptibility_to0.56480820
116MP0002166_altered_tumor_susceptibility0.51939484
117MP0002139_abnormal_hepatobiliary_system0.51931054
118MP0000609_abnormal_liver_physiology0.48558871
119MP0005023_abnormal_wound_healing0.46921322
120MP0000767_abnormal_smooth_muscle0.46115204
121MP0004130_abnormal_muscle_cell0.45343735
122MP0002136_abnormal_kidney_physiology0.44451970
123MP0002295_abnormal_pulmonary_circulatio0.43308863
124MP0005376_homeostasis/metabolism_phenot0.42185002
125MP0003566_abnormal_cell_adhesion0.42128511

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)9.76963258
2Eczematoid dermatitis (HP:0000976)9.02570930
3Recurrent bacterial skin infections (HP:0005406)8.70122900
4Recurrent gram-negative bacterial infections (HP:0005420)8.61828240
5Stomatitis (HP:0010280)6.42781418
6Mediastinal lymphadenopathy (HP:0100721)6.24512183
7Abnormality of macrophages (HP:0004311)6.14419288
8Gingivitis (HP:0000230)5.66430827
9Obstructive lung disease (HP:0006536)4.98014195
10Chronic obstructive pulmonary disease (HP:0006510)4.98014195
11Recurrent skin infections (HP:0001581)4.81668397
12Autoimmune thrombocytopenia (HP:0001973)4.80146472
13Hypochromic microcytic anemia (HP:0004840)4.44998094
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.10961609
15Axonal loss (HP:0003447)4.05040347
16Elevated erythrocyte sedimentation rate (HP:0003565)4.04758984
17Urticaria (HP:0001025)3.96771963
18Encephalitis (HP:0002383)3.94775173
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.85383034
20Periodontitis (HP:0000704)3.84686539
21Recurrent fungal infections (HP:0002841)3.81941339
22Orchitis (HP:0100796)3.81764327
23Increased IgE level (HP:0003212)3.74112387
24Increased cerebral lipofuscin (HP:0011813)3.70222865
25Hypochromic anemia (HP:0001931)3.69042129
26Interstitial pulmonary disease (HP:0006530)3.68191428
27Myositis (HP:0100614)3.61892615
28Optic neuritis (HP:0100653)3.60773610
29Retrobulbar optic neuritis (HP:0100654)3.60773610
30Systemic lupus erythematosus (HP:0002725)3.57245082
31Cellulitis (HP:0100658)3.57184960
32Pustule (HP:0200039)3.56376869
33Thick nail (HP:0001805)3.54972728
34Episodic fever (HP:0001954)3.46738660
35Increased IgM level (HP:0003496)3.38646817
36Chest pain (HP:0100749)3.37382448
37Vacuolated lymphocytes (HP:0001922)3.35201907
38Prolonged bleeding time (HP:0003010)3.31476040
39Vasculitis (HP:0002633)3.21415225
40Meningitis (HP:0001287)2.94199536
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92293954
42Recurrent viral infections (HP:0004429)2.89126967
43T lymphocytopenia (HP:0005403)2.87307197
44Recurrent pneumonia (HP:0006532)2.84079386
45Disinhibition (HP:0000734)2.68500819
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67797829
47Inflammation of the large intestine (HP:0002037)2.67509319
48Osteomyelitis (HP:0002754)2.66622554
49Premature loss of primary teeth (HP:0006323)2.66186547
50Nausea (HP:0002018)2.64086590
51Microcytic anemia (HP:0001935)2.63533774
52Gingival bleeding (HP:0000225)2.61127598
53Hepatosplenomegaly (HP:0001433)2.60369260
54Gastrointestinal inflammation (HP:0004386)2.57996409
55Tetraparesis (HP:0002273)2.57181779
56Basal ganglia calcification (HP:0002135)2.54295666
57Pulmonary infiltrates (HP:0002113)2.54033495
58Abnormality of T cells (HP:0002843)2.52431237
59Glomerulonephritis (HP:0000099)2.51244735
60Gangrene (HP:0100758)2.48689267
61Granulocytopenia (HP:0001913)2.43731686
62Abnormality of the peritoneum (HP:0002585)2.42875833
63Panhypogammaglobulinemia (HP:0003139)2.41881305
64Joint hemorrhage (HP:0005261)2.40956652
65Leukocytosis (HP:0001974)2.39848016
66Purpura (HP:0000979)2.39470208
67Spontaneous hematomas (HP:0007420)2.37349912
68Prostate neoplasm (HP:0100787)2.34443276
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33237092
70Recurrent lower respiratory tract infections (HP:0002783)2.32781359
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.30833023
72Osteolytic defects of the hand bones (HP:0009699)2.30833023
73Joint swelling (HP:0001386)2.30595543
74Agnosia (HP:0010524)2.27655736
75Lymphopenia (HP:0001888)2.26300987
76Abnormality of the endocardium (HP:0004306)2.25051928
77Sepsis (HP:0100806)2.22802085
78Abnormality of T cell physiology (HP:0011840)2.20183994
79Hematochezia (HP:0002573)2.19552494
80Keratoconjunctivitis sicca (HP:0001097)2.17673223
81Glomerulopathy (HP:0100820)2.17590077
82Poor head control (HP:0002421)2.15386833
83Keratitis (HP:0000491)2.14214509
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.13737468
85Acne (HP:0001061)2.11973874
86Recurrent cutaneous fungal infections (HP:0011370)2.11466577
87Chronic mucocutaneous candidiasis (HP:0002728)2.11466577
88Peritonitis (HP:0002586)2.10992874
89Chronic otitis media (HP:0000389)2.10585335
90Vertigo (HP:0002321)2.09171175
91Hypergammaglobulinemia (HP:0010702)2.08114124
92Petechiae (HP:0000967)2.07467548
93Arterial thrombosis (HP:0004420)2.04955223
94IgM deficiency (HP:0002850)2.04335852
95Acute hepatic failure (HP:0006554)2.04014639
96Myocardial infarction (HP:0001658)2.03929351
97Abnormal platelet volume (HP:0011876)2.02449492
98Metaphyseal cupping (HP:0003021)2.00843883
99Bone pain (HP:0002653)1.99684435
100Nephritis (HP:0000123)1.97093971
101Hemoptysis (HP:0002105)1.96516386
102Keratoconjunctivitis (HP:0001096)1.96112666
103Gastrointestinal infarctions (HP:0005244)1.95242431
104Slow saccadic eye movements (HP:0000514)1.94823772
105Toxemia of pregnancy (HP:0100603)1.94314176
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.94123082
107Dysostosis multiplex (HP:0000943)1.93636906
108Increased serum ferritin (HP:0003281)1.88998822
109Loss of speech (HP:0002371)1.88785897
110Difficulty running (HP:0009046)1.88668029
111Epistaxis (HP:0000421)1.87072479
112Skin ulcer (HP:0200042)1.86444222
113Arthralgia (HP:0002829)1.86239770
114Polycythemia (HP:0001901)1.85971489
115Abnormality of the pericardium (HP:0001697)1.85658643
116Cheilitis (HP:0100825)1.85580471
117Segmental peripheral demyelination/remyelination (HP:0003481)1.85519659
118Subacute progressive viral hepatitis (HP:0006572)1.85148116
119Amyloidosis (HP:0011034)1.84742116
120Polyneuropathy (HP:0001271)1.84427414
121Abnormality of T cell number (HP:0011839)1.83853059
122Viral hepatitis (HP:0006562)1.83495220
123Skin rash (HP:0000988)1.81821844
124Recurrent sinusitis (HP:0011108)1.80024353
125Neoplasm of head and neck (HP:0012288)1.79469081
126Esophageal neoplasm (HP:0100751)1.79469081
127Colitis (HP:0002583)1.78653605
128Progressive visual loss (HP:0000529)1.77920053
129Abnormality of iron homeostasis (HP:0011031)1.77861601
130Upper motor neuron abnormality (HP:0002127)1.75499938
131Peripheral demyelination (HP:0011096)1.74496848
132Abnormality of the pleura (HP:0002103)1.71557290
133Pulmonary embolism (HP:0002204)1.70842868
134Abnormality of liposaccharide metabolism (HP:0010968)1.69625375
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.69625375
136Abnormality of glycolipid metabolism (HP:0010969)1.69625375
137Parakeratosis (HP:0001036)1.68955701
138Hypermelanotic macule (HP:0001034)1.67618800
139Eosinophilia (HP:0001880)1.66789483
140Anorexia (HP:0002039)1.66660449
141Abnormality of the common coagulation pathway (HP:0010990)1.66084799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.38912996
2BLK4.93438714
3MAP3K144.13291506
4IRAK43.35440799
5IRAK33.21567874
6PBK2.86344532
7TXK2.74325075
8TBK12.72513093
9FGR2.62029213
10TNK22.57970541
11CSK2.56034509
12MAP4K12.48165673
13TYK22.26184430
14IKBKE2.21079174
15ERN12.13479638
16TAOK12.04100960
17JAK32.01849362
18RIPK11.96126799
19IKBKB1.83022711
20PRPF4B1.78465287
21EPHB11.58088967
22SIK31.45481489
23HCK1.42482450
24STK101.41754936
25JAK11.38855585
26MAP3K131.36246929
27BMPR21.36096381
28LYN1.34268583
29CLK11.32102713
30ZAP701.32054271
31BTK1.25075110
32SYK1.21163408
33YES11.14856191
34TEC1.11934520
35PTK61.10028078
36FES1.09239719
37MAP3K121.07518429
38MARK21.06709643
39MATK1.06517703
40CSF1R1.06497802
41PRKCD1.05717050
42KIT1.05196590
43PRKD21.04216529
44CDK191.02864574
45MARK30.99282320
46MST1R0.98545503
47MAP3K60.98230202
48JAK20.97504829
49LCK0.95854187
50ABL20.93992650
51CHUK0.92288559
52SIK20.90364106
53ERBB30.90012484
54EIF2AK20.89200596
55RPS6KA40.86085963
56MST40.83668462
57MAP3K20.83322277
58MAP2K40.83016604
59TAOK20.82014974
60KSR20.80475189
61BMPR1B0.79357518
62TRIB30.78755053
63EGFR0.78585356
64TESK20.76639555
65BMX0.73229895
66ERBB40.72600084
67SMG10.72338827
68PTK2B0.71789888
69PRKG20.70892882
70MAP3K70.70641511
71GRK70.70459566
72LRRK20.70066744
73FGFR40.68449481
74STK110.68191035
75MAP2K30.67882064
76DYRK1B0.66303657
77TRPM70.65375517
78FYN0.64456181
79PIM20.62103246
80ABL10.61208809
81DAPK20.59232733
82STK380.59210445
83MAPK120.57628996
84PIM10.55202828
85TGFBR20.54713333
86IRAK10.54437861
87IRAK20.54424737
88RAF10.54298340
89SGK30.52734041
90KSR10.52698645
91CDC42BPA0.51846564
92PDPK10.49935034
93RET0.49000224
94ALK0.48628093
95MAP2K60.48189939
96HIPK20.47306954
97SIK10.46949152
98MAPK70.45892824
99ITK0.45771512
100ARAF0.45596058
101PIK3CG0.44906990
102NLK0.44861137
103PDK10.42558166
104ACVR1B0.40640931
105PRKCZ0.40589486
106FGFR30.38812425
107STK40.38350027
108MAP3K10.37710594
109IGF1R0.37005719
110KDR0.36931310
111MAP3K50.36431258
112DYRK30.35049948
113TAOK30.34250173
114TTN0.34223434
115PRKCQ0.34186809
116MOS0.33716171
117GRK60.33491425
118INSR0.33369148
119PRKCH0.33187748
120SGK20.32975402
121CAMK1D0.32767584
122GRK50.31333524
123PKN10.31192931
124DAPK30.30406612
125CAMKK10.29901737
126MAP3K110.29728017
127MAP3K30.29453813
128EPHA30.29383491
129RPS6KA60.25594209
130DMPK0.25064590
131CDK40.22797485
132MAPKAPK20.22044811
133NME20.21576476
134MAPK40.20889382
135RPS6KL10.20713977
136RPS6KC10.20713977

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.28678156
2Leishmaniasis_Homo sapiens_hsa051403.84529791
3* Staphylococcus aureus infection_Homo sapiens_hsa051503.70849462
4Legionellosis_Homo sapiens_hsa051343.42120884
5Type I diabetes mellitus_Homo sapiens_hsa049402.80078411
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78524232
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.76175201
8Asthma_Homo sapiens_hsa053102.71371102
9Rheumatoid arthritis_Homo sapiens_hsa053232.60687847
10Malaria_Homo sapiens_hsa051442.60337266
11Pertussis_Homo sapiens_hsa051332.48018641
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.45552000
13Allograft rejection_Homo sapiens_hsa053302.37957622
14Tuberculosis_Homo sapiens_hsa051522.34289354
15African trypanosomiasis_Homo sapiens_hsa051432.33808086
16Salmonella infection_Homo sapiens_hsa051322.31992715
17Osteoclast differentiation_Homo sapiens_hsa043802.28301652
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.25802721
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23260940
20TNF signaling pathway_Homo sapiens_hsa046681.97547275
21Phagosome_Homo sapiens_hsa041451.88907581
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85985813
23Hematopoietic cell lineage_Homo sapiens_hsa046401.83044551
24Measles_Homo sapiens_hsa051621.61208105
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50598723
26Influenza A_Homo sapiens_hsa051641.44301857
27Chemokine signaling pathway_Homo sapiens_hsa040621.37476038
28Lysosome_Homo sapiens_hsa041421.36237438
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32002277
30Amoebiasis_Homo sapiens_hsa051461.28268195
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27113959
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22129644
33Non-small cell lung cancer_Homo sapiens_hsa052231.21084751
34Herpes simplex infection_Homo sapiens_hsa051681.19893977
35Toxoplasmosis_Homo sapiens_hsa051451.19179004
36Complement and coagulation cascades_Homo sapiens_hsa046101.16917430
37B cell receptor signaling pathway_Homo sapiens_hsa046621.15374143
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.07044964
39Prion diseases_Homo sapiens_hsa050201.05812845
40Shigellosis_Homo sapiens_hsa051311.03907374
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01325412
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00127153
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.98112508
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92622227
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90598593
46Apoptosis_Homo sapiens_hsa042100.89669605
47Endocytosis_Homo sapiens_hsa041440.89383473
48Steroid biosynthesis_Homo sapiens_hsa001000.86542274
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85406248
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.84402263
51Renal cell carcinoma_Homo sapiens_hsa052110.84286690
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80315787
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79613134
54Hepatitis B_Homo sapiens_hsa051610.79265852
55Hepatitis C_Homo sapiens_hsa051600.73866807
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.73209479
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71974507
58Notch signaling pathway_Homo sapiens_hsa043300.71429865
59Endometrial cancer_Homo sapiens_hsa052130.65835232
60Autoimmune thyroid disease_Homo sapiens_hsa053200.64262001
61Collecting duct acid secretion_Homo sapiens_hsa049660.63630960
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.63214472
63Choline metabolism in cancer_Homo sapiens_hsa052310.62057537
64Viral carcinogenesis_Homo sapiens_hsa052030.61844209
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59466107
66GnRH signaling pathway_Homo sapiens_hsa049120.58558021
67Mineral absorption_Homo sapiens_hsa049780.57845693
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57598785
69Antigen processing and presentation_Homo sapiens_hsa046120.56159219
70Colorectal cancer_Homo sapiens_hsa052100.53677635
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52879488
72Type II diabetes mellitus_Homo sapiens_hsa049300.50927849
73T cell receptor signaling pathway_Homo sapiens_hsa046600.50699043
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.50101451
75MAPK signaling pathway_Homo sapiens_hsa040100.48494977
76Inositol phosphate metabolism_Homo sapiens_hsa005620.48436783
77Platelet activation_Homo sapiens_hsa046110.48291831
78Viral myocarditis_Homo sapiens_hsa054160.47401646
79Other glycan degradation_Homo sapiens_hsa005110.46748547
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.46485047
81mTOR signaling pathway_Homo sapiens_hsa041500.46430412
82HTLV-I infection_Homo sapiens_hsa051660.45886400
83* Rap1 signaling pathway_Homo sapiens_hsa040150.44794447
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.44780230
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44692281
86Caffeine metabolism_Homo sapiens_hsa002320.44080922
87Folate biosynthesis_Homo sapiens_hsa007900.43652103
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43344531
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.42520937
90Histidine metabolism_Homo sapiens_hsa003400.42410249
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41417722
92ErbB signaling pathway_Homo sapiens_hsa040120.40683939
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37816720
94Estrogen signaling pathway_Homo sapiens_hsa049150.35043397
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34061258
96Primary immunodeficiency_Homo sapiens_hsa053400.29252074
97Insulin resistance_Homo sapiens_hsa049310.28456998
98Acute myeloid leukemia_Homo sapiens_hsa052210.26592396
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.25646113
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25304082
101Regulation of autophagy_Homo sapiens_hsa041400.23459864
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23281161
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22147384
104HIF-1 signaling pathway_Homo sapiens_hsa040660.21841952
105Pentose phosphate pathway_Homo sapiens_hsa000300.20486548
106Epstein-Barr virus infection_Homo sapiens_hsa051690.20405847
107Fatty acid biosynthesis_Homo sapiens_hsa000610.20311742
108Pancreatic cancer_Homo sapiens_hsa052120.18660134
109Dorso-ventral axis formation_Homo sapiens_hsa043200.18534969
110VEGF signaling pathway_Homo sapiens_hsa043700.17491952
111Proteoglycans in cancer_Homo sapiens_hsa052050.15312017
112Vibrio cholerae infection_Homo sapiens_hsa051100.14271280
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14126354
114Peroxisome_Homo sapiens_hsa041460.12152007
115Arginine biosynthesis_Homo sapiens_hsa002200.11524863
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11523438
117Prolactin signaling pathway_Homo sapiens_hsa049170.10482530
118Sulfur relay system_Homo sapiens_hsa041220.10062486
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09900916
120Phenylalanine metabolism_Homo sapiens_hsa003600.09795180
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07896051
122FoxO signaling pathway_Homo sapiens_hsa040680.07798089
123Sphingolipid metabolism_Homo sapiens_hsa006000.07283870
124Chronic myeloid leukemia_Homo sapiens_hsa052200.06322218

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