

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neutrophil activation involved in immune response (GO:0002283) | 6.33811939 |
| 2 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.31998296 |
| 3 | negative regulation of cell killing (GO:0031342) | 6.31998296 |
| 4 | response to peptidoglycan (GO:0032494) | 6.15623160 |
| 5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.82542925 |
| 6 | hydrogen peroxide biosynthetic process (GO:0050665) | 5.69396172 |
| 7 | leukocyte aggregation (GO:0070486) | 5.64758101 |
| 8 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.61717291 |
| 9 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.61717291 |
| 10 | modulation by symbiont of host immune response (GO:0052553) | 5.61717291 |
| 11 | positive regulation by symbiont of host defense response (GO:0052509) | 5.61717291 |
| 12 | modulation by symbiont of host defense response (GO:0052031) | 5.61717291 |
| 13 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.61717291 |
| 14 | respiratory burst (GO:0045730) | 5.47659695 |
| 15 | production of molecular mediator involved in inflammatory response (GO:0002532) | 5.30408217 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.19220410 |
| 17 | reactive oxygen species biosynthetic process (GO:1903409) | 5.05622132 |
| 18 | granulocyte activation (GO:0036230) | 5.02194858 |
| 19 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.99465047 |
| 20 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.96974881 |
| 21 | superoxide anion generation (GO:0042554) | 4.96187427 |
| 22 | neutrophil activation (GO:0042119) | 4.86638149 |
| 23 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.85343147 |
| 24 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.81082888 |
| 25 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.74767657 |
| 26 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.62467619 |
| 27 | leukocyte migration involved in inflammatory response (GO:0002523) | 4.58871645 |
| 28 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 4.44596368 |
| 29 | positive regulation of mast cell degranulation (GO:0043306) | 4.44596368 |
| 30 | positive regulation of interferon-alpha production (GO:0032727) | 4.40956467 |
| 31 | immunoglobulin mediated immune response (GO:0016064) | 4.40471176 |
| 32 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.39156907 |
| 33 | macrophage activation involved in immune response (GO:0002281) | 4.34352149 |
| 34 | response to interleukin-15 (GO:0070672) | 4.34037430 |
| 35 | response to host immune response (GO:0052572) | 4.31704204 |
| 36 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.31704204 |
| 37 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 4.24563932 |
| 38 | regulation of gamma-delta T cell activation (GO:0046643) | 4.23236426 |
| 39 | positive regulation of mast cell activation (GO:0033005) | 4.21893599 |
| 40 | positive regulation of heat generation (GO:0031652) | 4.20834490 |
| 41 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.19394630 |
| 42 | regulation of fever generation (GO:0031620) | 4.18238629 |
| 43 | regulation of interferon-alpha production (GO:0032647) | 4.17074958 |
| 44 | regulation of chemokine biosynthetic process (GO:0045073) | 4.12812965 |
| 45 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 4.10641319 |
| 46 | cellular response to interleukin-15 (GO:0071350) | 4.02629929 |
| 47 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.97558463 |
| 48 | neutrophil mediated immunity (GO:0002446) | 3.88614948 |
| 49 | response to host defenses (GO:0052200) | 3.87789070 |
| 50 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.87789070 |
| 51 | response to host (GO:0075136) | 3.87789070 |
| 52 | detection of other organism (GO:0098543) | 3.85947287 |
| 53 | cellular extravasation (GO:0045123) | 3.80493821 |
| 54 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.77519438 |
| 55 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.77008905 |
| 56 | negative regulation of T cell mediated immunity (GO:0002710) | 3.76049161 |
| 57 | T-helper 1 type immune response (GO:0042088) | 3.74838477 |
| 58 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.72641060 |
| 59 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.72195956 |
| 60 | cellular response to type I interferon (GO:0071357) | 3.71819423 |
| 61 | type I interferon signaling pathway (GO:0060337) | 3.71819423 |
| 62 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.70498965 |
| 63 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.68657406 |
| 64 | natural killer cell mediated immunity (GO:0002228) | 3.68657406 |
| 65 | response to type I interferon (GO:0034340) | 3.68477366 |
| 66 | leukocyte mediated cytotoxicity (GO:0001909) | 3.67613269 |
| 67 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.66779073 |
| 68 | detection of molecule of bacterial origin (GO:0032490) | 3.63068947 |
| 69 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.61234409 |
| 70 | regulation of mast cell degranulation (GO:0043304) | 3.60440632 |
| 71 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.56185818 |
| 72 | myeloid cell activation involved in immune response (GO:0002275) | 3.55396810 |
| 73 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.45595838 |
| 74 | detection of external biotic stimulus (GO:0098581) | 3.45070140 |
| 75 | positive regulation of leukocyte degranulation (GO:0043302) | 3.44987668 |
| 76 | neutrophil chemotaxis (GO:0030593) | 3.44532593 |
| 77 | defense response to protozoan (GO:0042832) | 3.44133375 |
| 78 | negative regulation of viral genome replication (GO:0045071) | 3.42347850 |
| 79 | detection of bacterium (GO:0016045) | 3.40312893 |
| 80 | regulation of podosome assembly (GO:0071801) | 3.38227861 |
| 81 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.37670314 |
| 82 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.36550677 |
| 83 | regulation of mast cell activation (GO:0033003) | 3.36425314 |
| 84 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.35610226 |
| 85 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.35368566 |
| 86 | neutrophil migration (GO:1990266) | 3.35162708 |
| 87 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.34776491 |
| 88 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.34227793 |
| 89 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.34197309 |
| 90 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.33938385 |
| 91 | B cell mediated immunity (GO:0019724) | 3.33169337 |
| 92 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.30947751 |
| 93 | cellular response to exogenous dsRNA (GO:0071360) | 3.30298297 |
| 94 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.29966451 |
| 95 | B cell receptor signaling pathway (GO:0050853) | 3.28253984 |
| 96 | cellular response to interferon-alpha (GO:0035457) | 3.26730826 |
| 97 | dendritic cell migration (GO:0036336) | 3.24239284 |
| 98 | microglial cell activation (GO:0001774) | 3.23550924 |
| 99 | negative regulation of interleukin-17 production (GO:0032700) | 3.22378521 |
| 100 | cellular response to zinc ion (GO:0071294) | 3.22265627 |
| 101 | germinal center formation (GO:0002467) | 3.21282372 |
| 102 | macrophage activation (GO:0042116) | 3.20330816 |
| 103 | negative regulation of interleukin-12 production (GO:0032695) | 3.19977647 |
| 104 | response to muramyl dipeptide (GO:0032495) | 3.18913108 |
| 105 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.18026364 |
| 106 | positive regulation of type 2 immune response (GO:0002830) | 3.17341512 |
| 107 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.17028483 |
| 108 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.16873803 |
| 109 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.16873803 |
| 110 | leukocyte degranulation (GO:0043299) | 3.16404136 |
| 111 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.16224437 |
| 112 | regulation of heterotypic cell-cell adhesion (GO:0034114) | 3.15800222 |
| 113 | positive regulation of interferon-beta production (GO:0032728) | 3.15446010 |
| 114 | regulation of heat generation (GO:0031650) | 3.15030729 |
| 115 | dendritic cell chemotaxis (GO:0002407) | 3.14647617 |
| 116 | phagosome maturation (GO:0090382) | 3.14551241 |
| 117 | regulation of tolerance induction (GO:0002643) | 3.14342143 |
| 118 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.13403908 |
| 119 | sequestering of metal ion (GO:0051238) | 3.13288821 |
| 120 | myeloid leukocyte mediated immunity (GO:0002444) | 3.11652293 |
| 121 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.11166693 |
| 122 | response to interferon-alpha (GO:0035455) | 3.10939743 |
| 123 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.10555348 |
| 124 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.07501194 |
| 125 | granulocyte chemotaxis (GO:0071621) | 3.06736014 |
| 126 | lymphocyte chemotaxis (GO:0048247) | 3.06614139 |
| 127 | regulation of T cell tolerance induction (GO:0002664) | 3.05784172 |
| 128 | cellular response to interferon-beta (GO:0035458) | 3.04947917 |
| 129 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.01988922 |
| 130 | granulocyte migration (GO:0097530) | 3.01857595 |
| 131 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.01686647 |
| 132 | regulation of leukocyte degranulation (GO:0043300) | 3.01294561 |
| 133 | cytokine secretion (GO:0050663) | 3.00977403 |
| 134 | myeloid leukocyte activation (GO:0002274) | 3.00869444 |
| 135 | detection of biotic stimulus (GO:0009595) | 3.00508267 |
| 136 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 3.00087932 |
| 137 | regulation of B cell differentiation (GO:0045577) | 2.99506011 |
| 138 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.96960621 |
| 139 | negative regulation of interleukin-6 production (GO:0032715) | 2.92906410 |
| 140 | negative regulation of type 2 immune response (GO:0002829) | 2.92095262 |
| 141 | response to protozoan (GO:0001562) | 2.87247197 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 8.17660824 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 7.32534333 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.73603185 |
| 4 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.60070355 |
| 5 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.37179717 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.16274232 |
| 7 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.01447802 |
| 8 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.72398351 |
| 9 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.68856870 |
| 10 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.27263503 |
| 11 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.25166086 |
| 12 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.22625691 |
| 13 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.08997971 |
| 14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.77460259 |
| 15 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.73928971 |
| 16 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.71002689 |
| 17 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.56231779 |
| 18 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.45574558 |
| 19 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.21691689 |
| 20 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.13595074 |
| 21 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.07665967 |
| 22 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.02989999 |
| 23 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.82651725 |
| 24 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.77305544 |
| 25 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.69007716 |
| 26 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.66897835 |
| 27 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.66742283 |
| 28 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.64899383 |
| 29 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.64195062 |
| 30 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.62217068 |
| 31 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.59994473 |
| 32 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.58331360 |
| 33 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.54990058 |
| 34 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.54765586 |
| 35 | MYB_26560356_Chip-Seq_TH2_Human | 1.50816362 |
| 36 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.48769438 |
| 37 | MYC_22102868_ChIP-Seq_BL_Human | 1.48412890 |
| 38 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.42610494 |
| 39 | SPI1_23127762_ChIP-Seq_K562_Human | 1.40665949 |
| 40 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.39632118 |
| 41 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.39085356 |
| 42 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.38192326 |
| 43 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.38150540 |
| 44 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.38079760 |
| 45 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.31903132 |
| 46 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.31487590 |
| 47 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.29648408 |
| 48 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.26220169 |
| 49 | MAF_26560356_Chip-Seq_TH1_Human | 1.23104872 |
| 50 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.22791326 |
| 51 | GATA3_26560356_Chip-Seq_TH2_Human | 1.21245183 |
| 52 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.21062976 |
| 53 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.21046711 |
| 54 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.19467615 |
| 55 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.18291182 |
| 56 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17961343 |
| 57 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.16652280 |
| 58 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.15010725 |
| 59 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14053405 |
| 60 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.13239190 |
| 61 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.11993111 |
| 62 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.11751653 |
| 63 | MYB_26560356_Chip-Seq_TH1_Human | 1.11542032 |
| 64 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10620513 |
| 65 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.10089651 |
| 66 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.09641388 |
| 67 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.08857409 |
| 68 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.07000717 |
| 69 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.06810933 |
| 70 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.04581855 |
| 71 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.03716126 |
| 72 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.00891682 |
| 73 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.00891682 |
| 74 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.98525248 |
| 75 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97276380 |
| 76 | GATA1_22025678_ChIP-Seq_K562_Human | 0.96819728 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95489868 |
| 78 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.94747670 |
| 79 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94483863 |
| 80 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.94086402 |
| 81 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93658591 |
| 82 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.93522231 |
| 83 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92208515 |
| 84 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.91810406 |
| 85 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.88600819 |
| 86 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.87783401 |
| 87 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.87150348 |
| 88 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.85626415 |
| 89 | UTX_26944678_Chip-Seq_JUKART_Human | 0.82920427 |
| 90 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.82079081 |
| 91 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.81511619 |
| 92 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.81283120 |
| 93 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80717990 |
| 94 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.80648266 |
| 95 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.80434796 |
| 96 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.77121557 |
| 97 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.76565081 |
| 98 | GATA2_19941826_ChIP-Seq_K562_Human | 0.74969595 |
| 99 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.74108821 |
| 100 | GATA1_19941826_ChIP-Seq_K562_Human | 0.73048300 |
| 101 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.73026990 |
| 102 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.72586825 |
| 103 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.71319267 |
| 104 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.69822219 |
| 105 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.68792977 |
| 106 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.66974103 |
| 107 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.66801381 |
| 108 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.66241816 |
| 109 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.66222388 |
| 110 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.64165469 |
| 111 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.63608681 |
| 112 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.63385020 |
| 113 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.62489419 |
| 114 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.62433143 |
| 115 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.61013315 |
| 116 | MAF_26560356_Chip-Seq_TH2_Human | 0.60729003 |
| 117 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.59241084 |
| 118 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.58913405 |
| 119 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.58704530 |
| 120 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.57321166 |
| 121 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.57163711 |
| 122 | CJUN_26792858_Chip-Seq_BT549_Human | 0.56323765 |
| 123 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.56279828 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009785_altered_susceptibility_to | 4.87900138 |
| 2 | MP0003436_decreased_susceptibility_to | 4.71353472 |
| 3 | MP0001835_abnormal_antigen_presentation | 4.24177603 |
| 4 | MP0002148_abnormal_hypersensitivity_rea | 3.87257115 |
| 5 | MP0003303_peritoneal_inflammation | 3.69250438 |
| 6 | * MP0002419_abnormal_innate_immunity | 3.59216817 |
| 7 | MP0006082_CNS_inflammation | 3.53255431 |
| 8 | MP0005025_abnormal_response_to | 3.35386671 |
| 9 | * MP0005000_abnormal_immune_tolerance | 3.31882087 |
| 10 | MP0001790_abnormal_immune_system | 2.76081374 |
| 11 | MP0005387_immune_system_phenotype | 2.76081374 |
| 12 | MP0009764_decreased_sensitivity_to | 2.67188404 |
| 13 | MP0004510_myositis | 2.63018414 |
| 14 | MP0000685_abnormal_immune_system | 2.61924997 |
| 15 | * MP0002452_abnormal_antigen_presenting | 2.60978130 |
| 16 | * MP0003724_increased_susceptibility_to | 2.58981033 |
| 17 | * MP0002723_abnormal_immune_serum | 2.53062723 |
| 18 | * MP0001800_abnormal_humoral_immune | 2.38835027 |
| 19 | MP0005167_abnormal_blood-brain_barrier | 2.38718273 |
| 20 | MP0005058_abnormal_lysosome_morphology | 2.36147062 |
| 21 | MP0003075_altered_response_to | 2.33493836 |
| 22 | * MP0001533_abnormal_skeleton_physiology | 2.32833669 |
| 23 | MP0005671_abnormal_response_to | 2.29013279 |
| 24 | * MP0001819_abnormal_immune_cell | 2.25397259 |
| 25 | * MP0002420_abnormal_adaptive_immunity | 2.20839323 |
| 26 | MP0005464_abnormal_platelet_physiology | 2.14588201 |
| 27 | MP0002132_abnormal_respiratory_system | 2.10214101 |
| 28 | MP0004947_skin_inflammation | 2.07341104 |
| 29 | * MP0001845_abnormal_inflammatory_respons | 2.05395993 |
| 30 | MP0001853_heart_inflammation | 1.97415342 |
| 31 | MP0000343_altered_response_to | 1.94820883 |
| 32 | MP0002006_tumorigenesis | 1.94208784 |
| 33 | MP0003448_altered_tumor_morphology | 1.92479074 |
| 34 | MP0002405_respiratory_system_inflammati | 1.88968867 |
| 35 | MP0008469_abnormal_protein_level | 1.88014023 |
| 36 | MP0003763_abnormal_thymus_physiology | 1.87191747 |
| 37 | MP0000858_altered_metastatic_potential | 1.79871945 |
| 38 | MP0000465_gastrointestinal_hemorrhage | 1.66181385 |
| 39 | MP0005166_decreased_susceptibility_to | 1.62790140 |
| 40 | MP0003866_abnormal_defecation | 1.59362693 |
| 41 | MP0004381_abnormal_hair_follicle | 1.57493153 |
| 42 | MP0010155_abnormal_intestine_physiology | 1.54961168 |
| 43 | MP0003186_abnormal_redox_activity | 1.52920858 |
| 44 | MP0002998_abnormal_bone_remodeling | 1.51221348 |
| 45 | MP0003172_abnormal_lysosome_physiology | 1.47483650 |
| 46 | * MP0000716_abnormal_immune_system | 1.46167755 |
| 47 | MP0003191_abnormal_cellular_cholesterol | 1.39563424 |
| 48 | MP0002396_abnormal_hematopoietic_system | 1.39061258 |
| 49 | MP0000703_abnormal_thymus_morphology | 1.34094120 |
| 50 | MP0005310_abnormal_salivary_gland | 1.32720522 |
| 51 | MP0002398_abnormal_bone_marrow | 1.31255525 |
| 52 | MP0003195_calcinosis | 1.27454437 |
| 53 | MP0003183_abnormal_peptide_metabolism | 1.24199692 |
| 54 | MP0003828_pulmonary_edema | 1.22993273 |
| 55 | * MP0005164_abnormal_response_to | 1.22527314 |
| 56 | MP0004782_abnormal_surfactant_physiolog | 1.20706017 |
| 57 | MP0005076_abnormal_cell_differentiation | 1.15493961 |
| 58 | MP0002332_abnormal_exercise_endurance | 1.13017827 |
| 59 | * MP0002429_abnormal_blood_cell | 1.12129075 |
| 60 | MP0009333_abnormal_splenocyte_physiolog | 1.11976101 |
| 61 | MP0000604_amyloidosis | 1.11855506 |
| 62 | MP0003690_abnormal_glial_cell | 1.11783335 |
| 63 | MP0009763_increased_sensitivity_to | 1.11608616 |
| 64 | MP0008260_abnormal_autophagy | 1.09397261 |
| 65 | MP0004883_abnormal_blood_vessel | 1.05782350 |
| 66 | * MP0005390_skeleton_phenotype | 1.04745144 |
| 67 | MP0004858_abnormal_nervous_system | 1.03209844 |
| 68 | MP0002933_joint_inflammation | 1.02808063 |
| 69 | MP0001851_eye_inflammation | 1.02437358 |
| 70 | MP0002138_abnormal_hepatobiliary_system | 1.01712287 |
| 71 | MP0000689_abnormal_spleen_morphology | 1.00265517 |
| 72 | * MP0009278_abnormal_bone_marrow | 0.99340795 |
| 73 | * MP0002277_abnormal_respiratory_mucosa | 0.98556873 |
| 74 | MP0003646_muscle_fatigue | 0.93655384 |
| 75 | MP0009840_abnormal_foam_cell | 0.92967096 |
| 76 | MP0003453_abnormal_keratinocyte_physiol | 0.91264634 |
| 77 | MP0001663_abnormal_digestive_system | 0.86703617 |
| 78 | * MP0002722_abnormal_immune_system | 0.86285690 |
| 79 | MP0003221_abnormal_cardiomyocyte_apopto | 0.86129155 |
| 80 | MP0005075_abnormal_melanosome_morpholog | 0.85867650 |
| 81 | MP0000569_abnormal_digit_pigmentation | 0.84704057 |
| 82 | MP0000015_abnormal_ear_pigmentation | 0.82989642 |
| 83 | * MP0001545_abnormal_hematopoietic_system | 0.78829770 |
| 84 | * MP0005397_hematopoietic_system_phenotyp | 0.78829770 |
| 85 | MP0005535_abnormal_body_temperature | 0.77179845 |
| 86 | MP0004130_abnormal_muscle_cell | 0.76267390 |
| 87 | MP0000249_abnormal_blood_vessel | 0.76166779 |
| 88 | MP0003806_abnormal_nucleotide_metabolis | 0.75197920 |
| 89 | MP0010352_gastrointestinal_tract_polyps | 0.74351877 |
| 90 | MP0002166_altered_tumor_susceptibility | 0.74300401 |
| 91 | MP0001958_emphysema | 0.71643788 |
| 92 | MP0008874_decreased_physiological_sensi | 0.71468221 |
| 93 | MP0003656_abnormal_erythrocyte_physiolo | 0.70538904 |
| 94 | MP0004484_altered_response_of | 0.68440038 |
| 95 | MP0000920_abnormal_myelination | 0.67887592 |
| 96 | MP0000371_diluted_coat_color | 0.67529707 |
| 97 | MP0005451_abnormal_body_composition | 0.66752769 |
| 98 | MP0003795_abnormal_bone_structure | 0.65924632 |
| 99 | MP0010307_abnormal_tumor_latency | 0.65262664 |
| 100 | MP0001986_abnormal_taste_sensitivity | 0.64825409 |
| 101 | MP0003566_abnormal_cell_adhesion | 0.63942345 |
| 102 | MP0003787_abnormal_imprinting | 0.62619001 |
| 103 | MP0001501_abnormal_sleep_pattern | 0.62301439 |
| 104 | MP0003300_gastrointestinal_ulcer | 0.61954407 |
| 105 | MP0003045_fibrosis | 0.59292766 |
| 106 | MP0005319_abnormal_enzyme/_coenzyme | 0.59243665 |
| 107 | MP0003091_abnormal_cell_migration | 0.57585010 |
| 108 | MP0005174_abnormal_tail_pigmentation | 0.57561986 |
| 109 | MP0001873_stomach_inflammation | 0.56955441 |
| 110 | MP0002928_abnormal_bile_duct | 0.56475824 |
| 111 | MP0002133_abnormal_respiratory_system | 0.55534039 |
| 112 | MP0005388_respiratory_system_phenotype | 0.55534039 |
| 113 | MP0008004_abnormal_stomach_pH | 0.54186983 |
| 114 | MP0008873_increased_physiological_sensi | 0.53783403 |
| 115 | MP0000767_abnormal_smooth_muscle | 0.53529760 |
| 116 | MP0002136_abnormal_kidney_physiology | 0.53434617 |
| 117 | MP0000490_abnormal_crypts_of | 0.53212905 |
| 118 | MP0003878_abnormal_ear_physiology | 0.52732087 |
| 119 | MP0005377_hearing/vestibular/ear_phenot | 0.52732087 |
| 120 | MP0005023_abnormal_wound_healing | 0.52513197 |
| 121 | MP0004808_abnormal_hematopoietic_stem | 0.51451368 |
| 122 | MP0002693_abnormal_pancreas_physiology | 0.51247599 |
| 123 | MP0002254_reproductive_system_inflammat | 0.50763529 |
| 124 | MP0006054_spinal_hemorrhage | 0.50201073 |
| 125 | MP0009765_abnormal_xenobiotic_induced | 0.49876458 |
| 126 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.48758749 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 9.05560284 |
| 2 | Recurrent abscess formation (HP:0002722) | 8.81124354 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 8.26741418 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 8.19932810 |
| 5 | Mediastinal lymphadenopathy (HP:0100721) | 6.12354350 |
| 6 | Abnormality of macrophages (HP:0004311) | 5.79805125 |
| 7 | Gingivitis (HP:0000230) | 5.26596055 |
| 8 | Stomatitis (HP:0010280) | 5.11860762 |
| 9 | Autoimmune thrombocytopenia (HP:0001973) | 4.97843083 |
| 10 | Chronic obstructive pulmonary disease (HP:0006510) | 4.83375805 |
| 11 | Obstructive lung disease (HP:0006536) | 4.83375805 |
| 12 | Recurrent skin infections (HP:0001581) | 4.79995995 |
| 13 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.71768387 |
| 14 | Myositis (HP:0100614) | 4.43713733 |
| 15 | Increased IgM level (HP:0003496) | 4.41452977 |
| 16 | Orchitis (HP:0100796) | 4.32393003 |
| 17 | Recurrent fungal infections (HP:0002841) | 4.13805009 |
| 18 | Encephalitis (HP:0002383) | 3.98063464 |
| 19 | Retrobulbar optic neuritis (HP:0100654) | 3.95640879 |
| 20 | Optic neuritis (HP:0100653) | 3.95640879 |
| 21 | Vasculitis (HP:0002633) | 3.87509587 |
| 22 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.86963673 |
| 23 | Urticaria (HP:0001025) | 3.84971621 |
| 24 | Hypochromic microcytic anemia (HP:0004840) | 3.76345950 |
| 25 | Cellulitis (HP:0100658) | 3.59094193 |
| 26 | Interstitial pulmonary disease (HP:0006530) | 3.44402392 |
| 27 | Periodontitis (HP:0000704) | 3.39115063 |
| 28 | Chest pain (HP:0100749) | 3.35019350 |
| 29 | Systemic lupus erythematosus (HP:0002725) | 3.34170875 |
| 30 | Increased IgE level (HP:0003212) | 3.34099756 |
| 31 | T lymphocytopenia (HP:0005403) | 3.32192980 |
| 32 | Episodic fever (HP:0001954) | 3.31785368 |
| 33 | Axonal loss (HP:0003447) | 3.25778648 |
| 34 | Vacuolated lymphocytes (HP:0001922) | 3.20925287 |
| 35 | Basal ganglia calcification (HP:0002135) | 3.19536203 |
| 36 | Hypochromic anemia (HP:0001931) | 3.18849599 |
| 37 | Recurrent viral infections (HP:0004429) | 3.11315236 |
| 38 | Pustule (HP:0200039) | 3.10178880 |
| 39 | Recurrent pneumonia (HP:0006532) | 3.08217074 |
| 40 | Thick nail (HP:0001805) | 3.07941750 |
| 41 | Prolonged bleeding time (HP:0003010) | 3.05340784 |
| 42 | Meningitis (HP:0001287) | 3.03910858 |
| 43 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.01798312 |
| 44 | Prostate neoplasm (HP:0100787) | 2.97542883 |
| 45 | Tetraparesis (HP:0002273) | 2.84696911 |
| 46 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.83957242 |
| 47 | Hypergammaglobulinemia (HP:0010702) | 2.79533960 |
| 48 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.78361067 |
| 49 | Spontaneous hematomas (HP:0007420) | 2.76209371 |
| 50 | Increased cerebral lipofuscin (HP:0011813) | 2.75738646 |
| 51 | Recurrent cutaneous fungal infections (HP:0011370) | 2.72364236 |
| 52 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.72364236 |
| 53 | Pulmonary infiltrates (HP:0002113) | 2.70798289 |
| 54 | Abnormality of T cells (HP:0002843) | 2.67244510 |
| 55 | Recurrent lower respiratory tract infections (HP:0002783) | 2.67158533 |
| 56 | Abnormality of the peritoneum (HP:0002585) | 2.61116529 |
| 57 | Autoimmune hemolytic anemia (HP:0001890) | 2.60245212 |
| 58 | Gastrointestinal infarctions (HP:0005244) | 2.59459101 |
| 59 | Osteomyelitis (HP:0002754) | 2.59230769 |
| 60 | Hemoptysis (HP:0002105) | 2.52692641 |
| 61 | Gingival bleeding (HP:0000225) | 2.52521954 |
| 62 | Leukocytosis (HP:0001974) | 2.48688882 |
| 63 | Inflammation of the large intestine (HP:0002037) | 2.47914585 |
| 64 | Poor head control (HP:0002421) | 2.46018708 |
| 65 | Abnormality of the endocardium (HP:0004306) | 2.43435245 |
| 66 | Granulocytopenia (HP:0001913) | 2.43001268 |
| 67 | Glomerulonephritis (HP:0000099) | 2.40244922 |
| 68 | Hepatosplenomegaly (HP:0001433) | 2.40010067 |
| 69 | Keratitis (HP:0000491) | 2.38459808 |
| 70 | Keratoconjunctivitis sicca (HP:0001097) | 2.38354194 |
| 71 | Microcytic anemia (HP:0001935) | 2.38315426 |
| 72 | Disinhibition (HP:0000734) | 2.35369080 |
| 73 | Gastrointestinal inflammation (HP:0004386) | 2.34737092 |
| 74 | Peritonitis (HP:0002586) | 2.34204392 |
| 75 | Hematochezia (HP:0002573) | 2.29772019 |
| 76 | Glomerulopathy (HP:0100820) | 2.28547262 |
| 77 | Premature loss of primary teeth (HP:0006323) | 2.28235939 |
| 78 | Vertigo (HP:0002321) | 2.28017065 |
| 79 | Arterial thrombosis (HP:0004420) | 2.23131178 |
| 80 | Joint hemorrhage (HP:0005261) | 2.21929160 |
| 81 | Acne (HP:0001061) | 2.21199951 |
| 82 | Osteolytic defects of the hand bones (HP:0009699) | 2.18768482 |
| 83 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.18768482 |
| 84 | Sepsis (HP:0100806) | 2.18623579 |
| 85 | Keratoconjunctivitis (HP:0001096) | 2.16365895 |
| 86 | Abnormality of T cell physiology (HP:0011840) | 2.15646281 |
| 87 | Chronic otitis media (HP:0000389) | 2.12554843 |
| 88 | Abnormality of T cell number (HP:0011839) | 2.09209040 |
| 89 | Panhypogammaglobulinemia (HP:0003139) | 2.08699577 |
| 90 | Lymphopenia (HP:0001888) | 2.08657512 |
| 91 | Joint swelling (HP:0001386) | 2.08176047 |
| 92 | Porencephaly (HP:0002132) | 2.05879684 |
| 93 | Acute hepatic failure (HP:0006554) | 2.05624488 |
| 94 | Subacute progressive viral hepatitis (HP:0006572) | 2.05598766 |
| 95 | Skin ulcer (HP:0200042) | 2.00215717 |
| 96 | Petechiae (HP:0000967) | 2.00166828 |
| 97 | Slow saccadic eye movements (HP:0000514) | 1.99832837 |
| 98 | Nephritis (HP:0000123) | 1.99651922 |
| 99 | Abnormality of the pericardium (HP:0001697) | 1.98135093 |
| 100 | Arthralgia (HP:0002829) | 1.97931102 |
| 101 | Dysostosis multiplex (HP:0000943) | 1.97828605 |
| 102 | Polyneuropathy (HP:0001271) | 1.96812040 |
| 103 | Myocardial infarction (HP:0001658) | 1.95057878 |
| 104 | Recurrent bronchitis (HP:0002837) | 1.94718160 |
| 105 | Purpura (HP:0000979) | 1.93768758 |
| 106 | Abnormality of the pleura (HP:0002103) | 1.93528049 |
| 107 | Anorexia (HP:0002039) | 1.92302845 |
| 108 | Bone pain (HP:0002653) | 1.90952963 |
| 109 | Thrombophlebitis (HP:0004418) | 1.90751983 |
| 110 | Epistaxis (HP:0000421) | 1.89140846 |
| 111 | Agnosia (HP:0010524) | 1.88703786 |
| 112 | Neoplasm of head and neck (HP:0012288) | 1.88695797 |
| 113 | Esophageal neoplasm (HP:0100751) | 1.88695797 |
| 114 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.88476380 |
| 115 | Amyloidosis (HP:0011034) | 1.86324696 |
| 116 | Abnormality of eosinophils (HP:0001879) | 1.85893007 |
| 117 | Viral hepatitis (HP:0006562) | 1.85738422 |
| 118 | Cheilitis (HP:0100825) | 1.85687968 |
| 119 | Pulmonary embolism (HP:0002204) | 1.85563231 |
| 120 | Skin rash (HP:0000988) | 1.83025202 |
| 121 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.82355615 |
| 122 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.82106422 |
| 123 | Loss of speech (HP:0002371) | 1.81380483 |
| 124 | Abnormality of glycolipid metabolism (HP:0010969) | 1.80960937 |
| 125 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.80960937 |
| 126 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.80960937 |
| 127 | Eosinophilia (HP:0001880) | 1.80368914 |
| 128 | Metaphyseal cupping (HP:0003021) | 1.79661691 |
| 129 | Parakeratosis (HP:0001036) | 1.79488395 |
| 130 | Abnormal platelet volume (HP:0011876) | 1.79230842 |
| 131 | Increased serum ferritin (HP:0003281) | 1.79219216 |
| 132 | Difficulty running (HP:0009046) | 1.76174826 |
| 133 | Vertebral compression fractures (HP:0002953) | 1.75897793 |
| 134 | Progressive visual loss (HP:0000529) | 1.74728778 |
| 135 | Colitis (HP:0002583) | 1.73809059 |
| 136 | Gangrene (HP:0100758) | 1.73808063 |
| 137 | Gastrointestinal stroma tumor (HP:0100723) | 1.73322751 |
| 138 | Esophageal varix (HP:0002040) | 1.73098064 |
| 139 | Nausea (HP:0002018) | 1.72985734 |
| 140 | Polycythemia (HP:0001901) | 1.72951541 |
| 141 | Hypermelanotic macule (HP:0001034) | 1.71976320 |
| 142 | Amaurosis fugax (HP:0100576) | 1.71423951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 6.17105040 |
| 2 | PBK | 4.77941158 |
| 3 | MAP3K14 | 4.38674803 |
| 4 | BLK | 3.82456484 |
| 5 | IRAK4 | 3.77060146 |
| 6 | TBK1 | 3.21990648 |
| 7 | IRAK3 | 2.56338569 |
| 8 | TYK2 | 2.53363793 |
| 9 | CSK | 2.48368260 |
| 10 | IKBKE | 2.44848131 |
| 11 | ERN1 | 2.41378025 |
| 12 | IKBKB | 2.07137589 |
| 13 | TNK2 | 2.05459451 |
| 14 | FGR | 2.03443390 |
| 15 | TXK | 1.99620432 |
| 16 | JAK3 | 1.96528065 |
| 17 | TAOK1 | 1.78904176 |
| 18 | MAP3K3 | 1.74872428 |
| 19 | JAK1 | 1.67014128 |
| 20 | MAP4K1 | 1.63822953 |
| 21 | PRPF4B | 1.60325371 |
| 22 | EPHB1 | 1.59584610 |
| 23 | MAP3K13 | 1.46497426 |
| 24 | BMPR2 | 1.46094765 |
| 25 | PIM2 | 1.42269408 |
| 26 | HCK | 1.42073409 |
| 27 | RIPK1 | 1.30179402 |
| 28 | MARK3 | 1.26841563 |
| 29 | ZAP70 | 1.24047138 |
| 30 | MATK | 1.23826110 |
| 31 | BTK | 1.22651186 |
| 32 | YES1 | 1.20844649 |
| 33 | LYN | 1.20344772 |
| 34 | MST4 | 1.19764755 |
| 35 | SYK | 1.19181181 |
| 36 | KIT | 1.18239185 |
| 37 | TEC | 1.17245529 |
| 38 | MAP3K6 | 1.14976183 |
| 39 | CHUK | 1.11248805 |
| 40 | STK10 | 1.09801797 |
| 41 | MAP3K2 | 1.08722801 |
| 42 | ABL2 | 1.07338057 |
| 43 | JAK2 | 0.99033457 |
| 44 | MAP3K5 | 0.98759897 |
| 45 | MST1R | 0.97802228 |
| 46 | STK4 | 0.96283568 |
| 47 | CLK1 | 0.96212993 |
| 48 | RPS6KA4 | 0.94293554 |
| 49 | EIF2AK2 | 0.93552435 |
| 50 | MARK2 | 0.93490285 |
| 51 | LCK | 0.92041538 |
| 52 | PIM1 | 0.89106852 |
| 53 | CDK19 | 0.88759590 |
| 54 | MAP2K4 | 0.88611628 |
| 55 | BMX | 0.85932857 |
| 56 | NEK9 | 0.84797018 |
| 57 | ERBB3 | 0.84372194 |
| 58 | FES | 0.82717190 |
| 59 | FGFR4 | 0.79059399 |
| 60 | ARAF | 0.78906306 |
| 61 | TRPM7 | 0.78831674 |
| 62 | PRKCD | 0.78543275 |
| 63 | PTK2B | 0.78219120 |
| 64 | PRKD2 | 0.76268564 |
| 65 | MAP3K12 | 0.74948703 |
| 66 | TAOK2 | 0.73905104 |
| 67 | CSF1R | 0.73605116 |
| 68 | KSR2 | 0.73420907 |
| 69 | FGFR3 | 0.73178135 |
| 70 | RAF1 | 0.69994876 |
| 71 | STK11 | 0.65757938 |
| 72 | EGFR | 0.65621824 |
| 73 | EPHA3 | 0.65023078 |
| 74 | ABL1 | 0.64901425 |
| 75 | IRAK1 | 0.63798019 |
| 76 | GRK7 | 0.63401975 |
| 77 | MAP2K6 | 0.63259495 |
| 78 | KSR1 | 0.63255406 |
| 79 | DYRK1B | 0.62181333 |
| 80 | PRKG2 | 0.59568460 |
| 81 | MAP3K7 | 0.57306972 |
| 82 | TESK2 | 0.55986883 |
| 83 | SGK3 | 0.54508021 |
| 84 | NLK | 0.54430597 |
| 85 | FYN | 0.54174949 |
| 86 | STK38 | 0.53950228 |
| 87 | MAP3K1 | 0.53017848 |
| 88 | WNK1 | 0.50891190 |
| 89 | IRAK2 | 0.50800986 |
| 90 | CDC42BPA | 0.50132762 |
| 91 | PRKCQ | 0.49733716 |
| 92 | NME2 | 0.48484668 |
| 93 | DYRK3 | 0.47784256 |
| 94 | RET | 0.47637366 |
| 95 | PDPK1 | 0.47534215 |
| 96 | MAP2K3 | 0.46834069 |
| 97 | SIK3 | 0.46759174 |
| 98 | MAP3K11 | 0.45957201 |
| 99 | HIPK2 | 0.45842697 |
| 100 | STK3 | 0.45802803 |
| 101 | LRRK2 | 0.45208554 |
| 102 | MAPK12 | 0.45005644 |
| 103 | ERBB4 | 0.44298390 |
| 104 | ITK | 0.43052000 |
| 105 | SGK2 | 0.42789451 |
| 106 | ADRBK1 | 0.42046745 |
| 107 | PRKCZ | 0.41819513 |
| 108 | TAOK3 | 0.40920131 |
| 109 | PDK1 | 0.40459636 |
| 110 | MAPK7 | 0.37951710 |
| 111 | BMPR1B | 0.37675253 |
| 112 | TGFBR2 | 0.37615871 |
| 113 | TRIB3 | 0.36189354 |
| 114 | TESK1 | 0.36138185 |
| 115 | RPS6KL1 | 0.35417319 |
| 116 | RPS6KC1 | 0.35417319 |
| 117 | ALK | 0.34596386 |
| 118 | SMG1 | 0.34055207 |
| 119 | GRK6 | 0.33465849 |
| 120 | MOS | 0.33295879 |
| 121 | MAPKAPK2 | 0.31510665 |
| 122 | SIK2 | 0.31280404 |
| 123 | CAMKK2 | 0.31132754 |
| 124 | DAPK2 | 0.27983331 |
| 125 | RPS6KA6 | 0.26701162 |
| 126 | PIK3CG | 0.25665507 |
| 127 | RPS6KA1 | 0.24577232 |
| 128 | INSR | 0.24324945 |
| 129 | IGF1R | 0.23880835 |
| 130 | ACVR1B | 0.23735802 |
| 131 | BCR | 0.23277113 |
| 132 | ADRBK2 | 0.22382586 |
| 133 | TTN | 0.19706471 |
| 134 | KDR | 0.18163654 |
| 135 | PTK6 | 0.17846639 |
| 136 | MAPK4 | 0.17583749 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.93001636 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.82957536 |
| 3 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 3.01325745 |
| 4 | * Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.00611644 |
| 5 | Legionellosis_Homo sapiens_hsa05134 | 2.98967878 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.73179449 |
| 7 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.72099746 |
| 8 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.66028817 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.63996289 |
| 10 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.59413065 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.54642567 |
| 12 | Pertussis_Homo sapiens_hsa05133 | 2.53082697 |
| 13 | Malaria_Homo sapiens_hsa05144 | 2.40271452 |
| 14 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.35945893 |
| 15 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.34188465 |
| 16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.29812318 |
| 17 | Tuberculosis_Homo sapiens_hsa05152 | 2.28708912 |
| 18 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.22561045 |
| 19 | African trypanosomiasis_Homo sapiens_hsa05143 | 2.13635856 |
| 20 | Salmonella infection_Homo sapiens_hsa05132 | 2.11317367 |
| 21 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.10371134 |
| 22 | Measles_Homo sapiens_hsa05162 | 2.00092758 |
| 23 | Influenza A_Homo sapiens_hsa05164 | 1.88761998 |
| 24 | Phagosome_Homo sapiens_hsa04145 | 1.68559760 |
| 25 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.60624374 |
| 26 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.57890143 |
| 27 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.51612841 |
| 28 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.50526472 |
| 29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.49659124 |
| 30 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.45260560 |
| 31 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.42176157 |
| 32 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.26538046 |
| 33 | Shigellosis_Homo sapiens_hsa05131 | 1.23093912 |
| 34 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.22631035 |
| 35 | Lysosome_Homo sapiens_hsa04142 | 1.20103862 |
| 36 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.19350561 |
| 37 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.16614631 |
| 38 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.16029676 |
| 39 | Amoebiasis_Homo sapiens_hsa05146 | 1.12018487 |
| 40 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.07994138 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.07282807 |
| 42 | Apoptosis_Homo sapiens_hsa04210 | 1.06526862 |
| 43 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.03602015 |
| 44 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.03099986 |
| 45 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.02275158 |
| 46 | Hepatitis B_Homo sapiens_hsa05161 | 0.99741882 |
| 47 | Hepatitis C_Homo sapiens_hsa05160 | 0.98210488 |
| 48 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.96504303 |
| 49 | Prion diseases_Homo sapiens_hsa05020 | 0.96420944 |
| 50 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.95991561 |
| 51 | Viral myocarditis_Homo sapiens_hsa05416 | 0.84089313 |
| 52 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.84054413 |
| 53 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.81591268 |
| 54 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.68449130 |
| 55 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.66465153 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.64447748 |
| 57 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.62208185 |
| 58 | Endometrial cancer_Homo sapiens_hsa05213 | 0.61964825 |
| 59 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.56997211 |
| 60 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.56950038 |
| 61 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.56527521 |
| 62 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.55816463 |
| 63 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55714629 |
| 64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.55428917 |
| 65 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.55089532 |
| 66 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.54771423 |
| 67 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.52875980 |
| 68 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.52785922 |
| 69 | Platelet activation_Homo sapiens_hsa04611 | 0.52305669 |
| 70 | Other glycan degradation_Homo sapiens_hsa00511 | 0.51241326 |
| 71 | Mineral absorption_Homo sapiens_hsa04978 | 0.51206753 |
| 72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50385161 |
| 73 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.49854224 |
| 74 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49525782 |
| 75 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47564152 |
| 76 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46626444 |
| 77 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.46429949 |
| 78 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.46075869 |
| 79 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.45339886 |
| 80 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.45237686 |
| 81 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.44286026 |
| 82 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.43263493 |
| 83 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.43099876 |
| 84 | Colorectal cancer_Homo sapiens_hsa05210 | 0.42056620 |
| 85 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.41825310 |
| 86 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.39126521 |
| 87 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.38865191 |
| 88 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.35779148 |
| 89 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35615901 |
| 90 | Prostate cancer_Homo sapiens_hsa05215 | 0.33643953 |
| 91 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.33048872 |
| 92 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.30485724 |
| 93 | Insulin resistance_Homo sapiens_hsa04931 | 0.26203969 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.25969365 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.25715279 |
| 96 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.25276460 |
| 97 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.23512127 |
| 98 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.23076657 |
| 99 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.22517857 |
| 100 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.18083482 |
| 101 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.17745545 |
| 102 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.17265438 |
| 103 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.16765821 |
| 104 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.15637472 |
| 105 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.14566418 |
| 106 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.14463245 |
| 107 | Endocytosis_Homo sapiens_hsa04144 | 0.13843596 |
| 108 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.12192741 |
| 109 | Histidine metabolism_Homo sapiens_hsa00340 | 0.11905571 |
| 110 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.11417240 |
| 111 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.11219850 |
| 112 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.09737442 |
| 113 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.08713714 |
| 114 | Proteasome_Homo sapiens_hsa03050 | 0.08394202 |
| 115 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.05393352 |
| 116 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.04316447 |
| 117 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.03171144 |
| 118 | HTLV-I infection_Homo sapiens_hsa05166 | 0.02785039 |

