FRAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.21315309
2regulation of gene silencing by miRNA (GO:0060964)5.21315309
3regulation of gene silencing by RNA (GO:0060966)5.21315309
4pre-miRNA processing (GO:0031054)4.71814856
5notochord development (GO:0030903)4.13281353
6positive regulation of SMAD protein import into nucleus (GO:0060391)3.92467128
7nuclear pore complex assembly (GO:0051292)3.81238710
8lung-associated mesenchyme development (GO:0060484)3.66386817
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.62538477
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.61878712
11heterochromatin organization (GO:0070828)3.59699005
12metanephric mesenchyme development (GO:0072075)3.58127555
13convergent extension (GO:0060026)3.49616233
14positive regulation of catenin import into nucleus (GO:0035413)3.49363075
15regulation of cell fate specification (GO:0042659)3.42603170
16insulin-like growth factor receptor signaling pathway (GO:0048009)3.42069755
17nuclear pore organization (GO:0006999)3.41957932
18anterior/posterior axis specification, embryo (GO:0008595)3.38899600
19lateral sprouting from an epithelium (GO:0060601)3.34806008
20regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.34651888
21glomerular visceral epithelial cell development (GO:0072015)3.32479141
22regulation of cardioblast differentiation (GO:0051890)3.27902770
23kidney mesenchyme development (GO:0072074)3.24348278
24gap junction assembly (GO:0016264)3.21533342
25nephron epithelium morphogenesis (GO:0072088)3.19444155
26nephron tubule morphogenesis (GO:0072078)3.19444155
27establishment of integrated proviral latency (GO:0075713)3.17725371
28cardiac myofibril assembly (GO:0055003)3.13639879
29mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.10530676
30establishment of nucleus localization (GO:0040023)3.07478857
31establishment of apical/basal cell polarity (GO:0035089)3.03234946
32membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.03093134
33embryonic skeletal joint morphogenesis (GO:0060272)3.01815620
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00918430
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.00810034
36regulation of translation, ncRNA-mediated (GO:0045974)3.00810034
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00810034
38hippo signaling (GO:0035329)3.00208716
39L-serine metabolic process (GO:0006563)2.99169272
40axon extension involved in axon guidance (GO:0048846)2.98915844
41neuron projection extension involved in neuron projection guidance (GO:1902284)2.98915844
42midgut development (GO:0007494)2.97682575
43cell proliferation involved in metanephros development (GO:0072203)2.97515796
44layer formation in cerebral cortex (GO:0021819)2.95811779
45proximal/distal pattern formation (GO:0009954)2.93000967
46membrane repolarization during action potential (GO:0086011)2.92381921
47body morphogenesis (GO:0010171)2.90304864
48embryonic foregut morphogenesis (GO:0048617)2.89380047
49bone trabecula formation (GO:0060346)2.88241167
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.87272469
51regulation of transforming growth factor beta2 production (GO:0032909)2.86795136
52glomerular epithelial cell development (GO:0072310)2.86460510
53auditory behavior (GO:0031223)2.86336295
54outflow tract septum morphogenesis (GO:0003148)2.86193330
55paraxial mesoderm development (GO:0048339)2.85509679
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84709956
57synaptic vesicle docking involved in exocytosis (GO:0016081)2.79267044
58L-alpha-amino acid transmembrane transport (GO:1902475)2.77487820
59regulation of SMAD protein import into nucleus (GO:0060390)2.76904855
60renal tubule morphogenesis (GO:0061333)2.75214283
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73756042
62protein complex localization (GO:0031503)2.73305213
63endocardial cushion development (GO:0003197)2.72678586
64plasma lipoprotein particle assembly (GO:0034377)2.72603017
65mesenchyme morphogenesis (GO:0072132)2.71594433
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71131317
67mitotic sister chromatid cohesion (GO:0007064)2.70919860
68regulation of gene silencing (GO:0060968)2.70853778
69mesenchymal cell proliferation (GO:0010463)2.70560153
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70173742
71negative regulation of cell fate specification (GO:0009996)2.69992320
72regulation of catenin import into nucleus (GO:0035412)2.69420733
73cell migration involved in gastrulation (GO:0042074)2.69331413
74regulation of bile acid biosynthetic process (GO:0070857)2.68714981
75sequestering of extracellular ligand from receptor (GO:0035581)2.68701194
76cell communication by electrical coupling (GO:0010644)2.68095482
77regulation of stem cell maintenance (GO:2000036)2.67371588
78branching involved in salivary gland morphogenesis (GO:0060445)2.66348015
79regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65975012
80protein localization to kinetochore (GO:0034501)2.65972109
81negative regulation of chondrocyte differentiation (GO:0032331)2.65433434
82locomotory exploration behavior (GO:0035641)2.65381544
83head development (GO:0060322)2.63360977
84establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63141965
85very-low-density lipoprotein particle assembly (GO:0034379)2.59231611
86vocalization behavior (GO:0071625)2.59100251
87cell proliferation involved in kidney development (GO:0072111)2.58912812
88regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58703033
89cell surface receptor signaling pathway involved in heart development (GO:0061311)2.57782335
90branching involved in ureteric bud morphogenesis (GO:0001658)2.56500896
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53470037
92craniofacial suture morphogenesis (GO:0097094)2.51757428
93anterior/posterior axis specification (GO:0009948)2.51647593
94negative regulation of sodium ion transport (GO:0010766)2.50665119
95neuronal ion channel clustering (GO:0045161)2.50617370
96embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50251506
97regulation of dendritic spine morphogenesis (GO:0061001)2.50207377
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50015411
99lysine metabolic process (GO:0006553)2.49845670
100lysine catabolic process (GO:0006554)2.49845670
101polarized epithelial cell differentiation (GO:0030859)2.49067173
102exocrine pancreas development (GO:0031017)2.48494594
103pore complex assembly (GO:0046931)2.48088235
104mesenchyme development (GO:0060485)2.47356268
105ephrin receptor signaling pathway (GO:0048013)2.47157379
106establishment or maintenance of monopolar cell polarity (GO:0061339)2.46218901
107establishment of monopolar cell polarity (GO:0061162)2.46218901
108atrial septum morphogenesis (GO:0060413)2.45664288
109heart morphogenesis (GO:0003007)2.45569806
110regulation of cell fate commitment (GO:0010453)2.43891474
111lung epithelium development (GO:0060428)2.43874052
112negative chemotaxis (GO:0050919)2.43532812
113endocardial cushion morphogenesis (GO:0003203)2.43040183
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43019021
115non-canonical Wnt signaling pathway (GO:0035567)2.40797923
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.40681604
117regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.40461371
118regulation of apoptotic cell clearance (GO:2000425)2.40194802
119glucocorticoid receptor signaling pathway (GO:0042921)2.40139633
120positive regulation of smoothened signaling pathway (GO:0045880)2.39668344
121mesenchymal to epithelial transition (GO:0060231)2.39366348
122regulation of heart rate by cardiac conduction (GO:0086091)2.39127878
123DNA unwinding involved in DNA replication (GO:0006268)2.38730186
124regulation of hippo signaling (GO:0035330)2.37973693
125camera-type eye morphogenesis (GO:0048593)2.37078202
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36859417
127Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.36278550
128gastrulation with mouth forming second (GO:0001702)2.35980493
129dendritic spine morphogenesis (GO:0060997)2.35628321
130collecting duct development (GO:0072044)2.35199081
131synaptic vesicle maturation (GO:0016188)2.35163330
132innervation (GO:0060384)2.35155588
133embryonic digit morphogenesis (GO:0042733)2.34253871
134regulation of glutamate receptor signaling pathway (GO:1900449)2.34245018
135nephron tubule formation (GO:0072079)2.34191331
136negative regulation of vascular permeability (GO:0043116)2.33058733
137negative regulation of cartilage development (GO:0061037)2.32977369
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.32876595
139dorsal/ventral axis specification (GO:0009950)2.32718379
140cochlea development (GO:0090102)2.32661239
141protein-lipid complex assembly (GO:0065005)2.32520191
142cell communication involved in cardiac conduction (GO:0086065)2.31216017
143negative regulation of DNA repair (GO:0045738)2.29993504
144myofibril assembly (GO:0030239)2.29963346
145generation of neurons (GO:0048699)2.29644486
146ectodermal placode formation (GO:0060788)2.29092472
147negative regulation of keratinocyte proliferation (GO:0010839)2.28817938
148hindlimb morphogenesis (GO:0035137)2.28369950
149regulation of axon guidance (GO:1902667)2.28290044
150cell migration involved in sprouting angiogenesis (GO:0002042)2.28042989
151regulation of mesenchymal cell apoptotic process (GO:2001053)2.28011935
152glomerulus development (GO:0032835)2.27646202
153cardiac conduction (GO:0061337)2.27554837
154axonal fasciculation (GO:0007413)2.27402473
155neural tube closure (GO:0001843)2.27218380
156positive regulation of mesenchymal cell proliferation (GO:0002053)2.27159934
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27150801
158negative regulation of cell fate commitment (GO:0010454)2.26091941
159negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.25307151
160regulation of establishment of planar polarity (GO:0090175)2.25276806
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.24959821
162tube closure (GO:0060606)2.24770110
163regulation of RNA export from nucleus (GO:0046831)2.23466386
164regulation of axon extension involved in axon guidance (GO:0048841)2.23369572
165positive regulation of gastrulation (GO:2000543)2.23298285
166NLS-bearing protein import into nucleus (GO:0006607)2.23181717
167neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.22929475
168morphogenesis of an epithelial sheet (GO:0002011)2.22768486
169regulation of mesenchymal cell proliferation (GO:0010464)2.22729616
170dendrite morphogenesis (GO:0048813)2.22486941
171* appendage morphogenesis (GO:0035107)2.22268388
172* limb morphogenesis (GO:0035108)2.22268388
173chondrocyte proliferation (GO:0035988)2.22021082
174cell fate commitment involved in formation of primary germ layer (GO:0060795)2.21427779
175nucleosome disassembly (GO:0006337)2.21212211
176protein-DNA complex disassembly (GO:0032986)2.21212211
177cellular protein complex localization (GO:0034629)2.20486736
178endothelial cell morphogenesis (GO:0001886)2.20459580
179regulation of gastrulation (GO:0010470)2.19735480
180female gonad development (GO:0008585)2.19711632
181mesenchymal cell differentiation (GO:0048762)2.18287551
182presynaptic membrane assembly (GO:0097105)2.16547485
183neural tube development (GO:0021915)2.15957334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22900896
2EZH2_22144423_ChIP-Seq_EOC_Human3.73137798
3NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.07336420
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97716003
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.89206449
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.89206449
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.89206449
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.79716795
9GBX2_23144817_ChIP-Seq_PC3_Human2.79243116
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73222052
11AR_21909140_ChIP-Seq_LNCAP_Human2.64789092
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.62244689
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61079916
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57990233
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55443735
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53237407
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53237407
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.51446487
19* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49985475
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34573953
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32712253
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31133493
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18034314
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17453785
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10964373
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09506899
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99515786
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97968563
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97275526
30NANOG_16153702_ChIP-ChIP_HESCs_Human1.96612437
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.92663954
32* EP300_21415370_ChIP-Seq_HL-1_Mouse1.91768364
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90617168
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90287067
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88577894
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87460456
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.86528782
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86189363
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85998838
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.83761611
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.80884831
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77965361
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77795471
44TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77718229
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.76791337
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74990629
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.74548142
48* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74535900
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.71384752
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66227351
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65743136
52DROSHA_22980978_ChIP-Seq_HELA_Human1.64413586
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64257420
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63836349
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.63006264
56TBX3_20139965_ChIP-Seq_ESCs_Mouse1.61206307
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61133086
58TBX3_20139965_ChIP-Seq_MESCs_Mouse1.60001870
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57465710
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56611197
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56240156
62ZNF274_21170338_ChIP-Seq_K562_Hela1.56227037
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55670195
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55395818
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.53736935
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52323608
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51558389
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50060433
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49352218
70* SMAD4_21799915_ChIP-Seq_A2780_Human1.49321832
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49052527
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47187417
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.45623239
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45213825
75AHR_22903824_ChIP-Seq_MCF-7_Human1.44950651
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44446096
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.43658656
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43495273
79FUS_26573619_Chip-Seq_HEK293_Human1.43349591
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43205776
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.42511113
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42498110
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42264996
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42029848
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.39822665
86MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39265723
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.39182146
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38949175
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37022502
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36614520
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35298072
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.35292337
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32969566
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32198455
95CLOCK_20551151_ChIP-Seq_293T_Human1.31982524
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.31297675
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.30798793
98AR_21572438_ChIP-Seq_LNCaP_Human1.29583709
99* AR_19668381_ChIP-Seq_PC3_Human1.29428525
100* P300_19829295_ChIP-Seq_ESCs_Human1.27508001
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27474810
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.26899010
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26772882
104TP53_18474530_ChIP-ChIP_U2OS_Human1.26508994
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26409611
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25188775
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.22183384
108TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21061100
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.20202211
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19832235
111RNF2_27304074_Chip-Seq_NSC_Mouse1.19733131
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18936503
113* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18790696
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18723080
115TAF15_26573619_Chip-Seq_HEK293_Human1.18325169
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18211633
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18139663
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17925560
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.17524974
120STAT3_23295773_ChIP-Seq_U87_Human1.17049040
121* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16462835
122EWS_26573619_Chip-Seq_HEK293_Human1.16245767
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15963535
124ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15426069
125SOX17_20123909_ChIP-Seq_XEN_Mouse1.14033234
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13858426
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.12220637
128POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11562866
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11147040
130TP53_20018659_ChIP-ChIP_R1E_Mouse1.11053804
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10569429
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09604131
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09328736
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08148156
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07654732
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07117164
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06701536
138* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06617776
139BCAT_22108803_ChIP-Seq_LS180_Human1.06605993
140TCF4_18268006_ChIP-ChIP_LS174T_Human1.06062355
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05359660
142* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04028303
143MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03920178
144SOX9_26525672_Chip-Seq_HEART_Mouse1.02958787
145* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02886842
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02619217
147* AR_25329375_ChIP-Seq_VCAP_Human1.01768866
148NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01731254
149TCF4_23295773_ChIP-Seq_U87_Human1.01467924
150* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01015615
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99942959
152TP63_19390658_ChIP-ChIP_HaCaT_Human0.98370266
153RXR_22108803_ChIP-Seq_LS180_Human0.98097217
154* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97958565
155NANOG_16518401_ChIP-PET_MESCs_Mouse0.97940394
156NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97518387
157YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94484255
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91858884
159* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91478590
160ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91445492
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90979303
162SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89826621
163NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88257578
164ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87707132
165POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87465058
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87465058
167PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86963612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.17883434
2MP0003123_paternal_imprinting3.28375787
3MP0002254_reproductive_system_inflammat2.95215938
4MP0003121_genomic_imprinting2.82144093
5MP0009053_abnormal_anal_canal2.78390390
6MP0000537_abnormal_urethra_morphology2.66905736
7MP0010030_abnormal_orbit_morphology2.64146078
8MP0000566_synostosis2.40710677
9* MP0003942_abnormal_urinary_system2.35292622
10MP0004859_abnormal_synaptic_plasticity2.34816832
11MP0004145_abnormal_muscle_electrophysio2.25300732
12MP0005248_abnormal_Harderian_gland2.15549223
13MP0003385_abnormal_body_wall2.12865883
14MP0009780_abnormal_chondrocyte_physiolo2.04705984
15* MP0002697_abnormal_eye_size2.00238404
16MP0004957_abnormal_blastocyst_morpholog1.97785999
17MP0000534_abnormal_ureter_morphology1.93381498
18* MP0004272_abnormal_basement_membrane1.92442049
19MP0003787_abnormal_imprinting1.87884206
20* MP0003115_abnormal_respiratory_system1.81598170
21MP0009250_abnormal_appendicular_skeleto1.77065131
22MP0005257_abnormal_intraocular_pressure1.73261891
23MP0002084_abnormal_developmental_patter1.66606648
24MP0003693_abnormal_embryo_hatching1.63353770
25MP0005503_abnormal_tendon_morphology1.62103656
26MP0002938_white_spotting1.59738582
27MP0003937_abnormal_limbs/digits/tail_de1.57831260
28MP0002089_abnormal_postnatal_growth/wei1.56398783
29MP0001730_embryonic_growth_arrest1.54795228
30MP0008932_abnormal_embryonic_tissue1.52582091
31MP0001672_abnormal_embryogenesis/_devel1.50954890
32MP0005380_embryogenesis_phenotype1.50954890
33MP0003111_abnormal_nucleus_morphology1.50885272
34MP0002085_abnormal_embryonic_tissue1.50469303
35MP0002249_abnormal_larynx_morphology1.49536813
36MP0003119_abnormal_digestive_system1.48834781
37MP0001177_atelectasis1.48560418
38MP0003283_abnormal_digestive_organ1.48246086
39MP0005187_abnormal_penis_morphology1.47837204
40MP0003705_abnormal_hypodermis_morpholog1.47048218
41MP0001849_ear_inflammation1.45738059
42MP0000049_abnormal_middle_ear1.44977741
43MP0008057_abnormal_DNA_replication1.44803885
44MP0003984_embryonic_growth_retardation1.43165221
45MP0010368_abnormal_lymphatic_system1.41629903
46MP0003755_abnormal_palate_morphology1.40786889
47MP0002088_abnormal_embryonic_growth/wei1.40646223
48MP0001346_abnormal_lacrimal_gland1.39875118
49MP0003935_abnormal_craniofacial_develop1.36933616
50MP0003136_yellow_coat_color1.36831434
51MP0003635_abnormal_synaptic_transmissio1.35717509
52MP0004133_heterotaxia1.35233689
53MP0003566_abnormal_cell_adhesion1.33935213
54MP0005623_abnormal_meninges_morphology1.30191217
55MP0002111_abnormal_tail_morphology1.29856892
56MP0002092_abnormal_eye_morphology1.29263782
57MP0010094_abnormal_chromosome_stability1.29220358
58MP0000516_abnormal_urinary_system1.28806474
59MP0005367_renal/urinary_system_phenotyp1.28806474
60MP0001915_intracranial_hemorrhage1.28500603
61MP0005076_abnormal_cell_differentiation1.28418583
62MP0000428_abnormal_craniofacial_morphol1.27906980
63MP0002932_abnormal_joint_morphology1.26804553
64MP0010352_gastrointestinal_tract_polyps1.26406981
65MP0001697_abnormal_embryo_size1.22922382
66MP0008438_abnormal_cutaneous_collagen1.20852078
67MP0002063_abnormal_learning/memory/cond1.20138539
68MP0002282_abnormal_trachea_morphology1.19575631
69MP0002086_abnormal_extraembryonic_tissu1.19367107
70MP0006292_abnormal_olfactory_placode1.18244608
71MP0000569_abnormal_digit_pigmentation1.17045241
72MP0002837_dystrophic_cardiac_calcinosis1.17001080
73MP0003890_abnormal_embryonic-extraembry1.16512296
74* MP0003941_abnormal_skin_development1.15872740
75MP0003880_abnormal_central_pattern1.15825083
76MP0010234_abnormal_vibrissa_follicle1.13179933
77MP0004233_abnormal_muscle_weight1.12748875
78MP0002233_abnormal_nose_morphology1.09900420
79MP0009384_cardiac_valve_regurgitation1.09410679
80MP0002116_abnormal_craniofacial_bone1.09024002
81MP0003950_abnormal_plasma_membrane1.08154256
82MP0000778_abnormal_nervous_system1.08120891
83MP0001299_abnormal_eye_distance/1.06269772
84MP0002108_abnormal_muscle_morphology1.05650614
85MP0003077_abnormal_cell_cycle1.03132553
86MP0004270_analgesia1.02965393
87* MP0002109_abnormal_limb_morphology1.02202375
88MP0002822_catalepsy1.01025227
89MP0010630_abnormal_cardiac_muscle0.99683621
90MP0003315_abnormal_perineum_morphology0.99661321
91MP0003718_maternal_effect0.99036597
92MP0004264_abnormal_extraembryonic_tissu0.98478631
93MP0009672_abnormal_birth_weight0.98074982
94* MP0002080_prenatal_lethality0.97519262
95MP0003279_aneurysm0.97373053
96MP0006138_congestive_heart_failure0.97076057
97MP0001293_anophthalmia0.96235487
98MP0010678_abnormal_skin_adnexa0.94659756
99MP0004085_abnormal_heartbeat0.93786739
100MP0003195_calcinosis0.93620763
101MP0001661_extended_life_span0.93378298
102MP0004858_abnormal_nervous_system0.92609804
103MP0002925_abnormal_cardiovascular_devel0.92035742
104MP0005508_abnormal_skeleton_morphology0.92015558
105MP0001486_abnormal_startle_reflex0.91964458
106MP0009697_abnormal_copulation0.91584382
107MP0002184_abnormal_innervation0.90598470
108MP0002115_abnormal_skeleton_extremities0.89663787
109MP0004084_abnormal_cardiac_muscle0.89465871
110MP0000579_abnormal_nail_morphology0.87227008
111MP0003861_abnormal_nervous_system0.86541054
112MP0002972_abnormal_cardiac_muscle0.86173422
113MP0000631_abnormal_neuroendocrine_gland0.85881763
114MP0003943_abnormal_hepatobiliary_system0.85558529
115MP0003137_abnormal_impulse_conducting0.85341445
116MP0002114_abnormal_axial_skeleton0.84773254
117MP0003938_abnormal_ear_development0.84530500
118MP0003878_abnormal_ear_physiology0.84501030
119MP0005377_hearing/vestibular/ear_phenot0.84501030
120MP0002234_abnormal_pharynx_morphology0.84230062
121MP0000955_abnormal_spinal_cord0.84087535
122MP0009745_abnormal_behavioral_response0.83148821
123MP0002928_abnormal_bile_duct0.82243419
124MP0000163_abnormal_cartilage_morphology0.82212468
125MP0000350_abnormal_cell_proliferation0.82193617
126MP0009703_decreased_birth_body0.81920890
127MP0000432_abnormal_head_morphology0.80932351
128MP0006054_spinal_hemorrhage0.80316741
129MP0000383_abnormal_hair_follicle0.78886737
130MP0001286_abnormal_eye_development0.78880464
131MP0002557_abnormal_social/conspecific_i0.78456248
132MP0002081_perinatal_lethality0.78119901
133MP0000762_abnormal_tongue_morphology0.77642396
134MP0001666_abnormal_nutrient_absorption0.77436303
135MP0005646_abnormal_pituitary_gland0.77305535
136MP0002177_abnormal_outer_ear0.77055628
137MP0005499_abnormal_olfactory_system0.76804543
138MP0005394_taste/olfaction_phenotype0.76804543
139MP0000462_abnormal_digestive_system0.76029187
140MP0003567_abnormal_fetal_cardiomyocyte0.75754413
141MP0002896_abnormal_bone_mineralization0.75705758
142MP0004197_abnormal_fetal_growth/weight/0.74991680

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.81348701
2Abnormality of the ischium (HP:0003174)4.38728753
3Short 4th metacarpal (HP:0010044)3.53823474
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53823474
5Abnormal pancreas size (HP:0012094)3.41239907
6Short tibia (HP:0005736)3.17230896
7Aplasia/Hypoplasia of the tibia (HP:0005772)2.99443318
8* Midline defect of the nose (HP:0004122)2.91630942
9* Cutaneous finger syndactyly (HP:0010554)2.83251264
10Anal stenosis (HP:0002025)2.78108716
11Abnormality of the 4th metacarpal (HP:0010012)2.77048569
12Deep venous thrombosis (HP:0002625)2.75806060
13Vaginal fistula (HP:0004320)2.71768144
14Abnormality of the aortic arch (HP:0012303)2.68445472
15Asymmetry of the thorax (HP:0001555)2.67967878
16Renal duplication (HP:0000075)2.65832432
17Rectal fistula (HP:0100590)2.60441474
18Rectovaginal fistula (HP:0000143)2.60441474
19Right ventricular cardiomyopathy (HP:0011663)2.58136387
20Myotonia (HP:0002486)2.52294815
21Diastasis recti (HP:0001540)2.49019794
22Intestinal fistula (HP:0100819)2.48531920
23Partial duplication of thumb phalanx (HP:0009944)2.46637137
24Enlarged kidneys (HP:0000105)2.41495689
25* Cutaneous syndactyly (HP:0012725)2.40514050
26Aplasia involving bones of the extremities (HP:0009825)2.39045025
27Aplasia involving bones of the upper limbs (HP:0009823)2.39045025
28Aplasia of the phalanges of the hand (HP:0009802)2.39045025
29Shallow orbits (HP:0000586)2.36927009
30Prolonged partial thromboplastin time (HP:0003645)2.29003922
31* Choanal stenosis (HP:0000452)2.28490685
32Overgrowth (HP:0001548)2.26054984
33Thin bony cortex (HP:0002753)2.25666418
34* Renal hypoplasia (HP:0000089)2.24595156
35Shawl scrotum (HP:0000049)2.24580741
36Broad alveolar ridges (HP:0000187)2.21899560
37Preaxial foot polydactyly (HP:0001841)2.21788454
38Neonatal short-limb short stature (HP:0008921)2.20445308
39Small epiphyses (HP:0010585)2.20357059
40Increased nuchal translucency (HP:0010880)2.19080535
41* Absent eyebrow (HP:0002223)2.17214935
42Papillary thyroid carcinoma (HP:0002895)2.16151406
43Duplication of thumb phalanx (HP:0009942)2.15743599
44Pterygium (HP:0001059)2.13500810
45Absent radius (HP:0003974)2.13486864
46Camptodactyly of toe (HP:0001836)2.11415657
47Vitreoretinal degeneration (HP:0000655)2.10553380
48Broad thumb (HP:0011304)2.10049335
49* Bifid tongue (HP:0010297)2.09943885
50* Morphological abnormality of the middle ear (HP:0008609)2.08063233
51Partial duplication of the phalanx of hand (HP:0009999)2.07682497
52* Myelomeningocele (HP:0002475)2.07049135
53* Bicornuate uterus (HP:0000813)2.06741082
54Broad toe (HP:0001837)2.06319414
55Impaired pain sensation (HP:0007328)2.05375027
56Abnormality of pain sensation (HP:0010832)2.05375027
57Septo-optic dysplasia (HP:0100842)2.04674835
58Spastic diplegia (HP:0001264)2.03929471
59Broad finger (HP:0001500)2.02211605
60Lymphangioma (HP:0100764)2.00607322
61Arnold-Chiari malformation (HP:0002308)2.00381952
62Microglossia (HP:0000171)1.98514944
63Alacrima (HP:0000522)1.98490561
64Broad phalanges of the hand (HP:0009768)1.98177534
65Mesomelia (HP:0003027)1.98085334
66Colon cancer (HP:0003003)1.96872578
67Absent forearm bone (HP:0003953)1.95595399
68Aplasia involving forearm bones (HP:0009822)1.95595399
69Limited elbow extension (HP:0001377)1.94475835
70Neonatal death (HP:0003811)1.93940044
71Irregular epiphyses (HP:0010582)1.92134170
72Hip contracture (HP:0003273)1.91625766
73Abnormality of the nasal septum (HP:0000419)1.91361379
74Abnormality of the labia minora (HP:0012880)1.90763629
75Ulnar deviation of finger (HP:0009465)1.90731966
76Hypoglycemic seizures (HP:0002173)1.90321896
77Broad metatarsal (HP:0001783)1.89373588
78Gastrointestinal carcinoma (HP:0002672)1.89220126
79Malignant gastrointestinal tract tumors (HP:0006749)1.89220126
80Esophageal atresia (HP:0002032)1.89205183
81* Anophthalmia (HP:0000528)1.88856591
82Knee flexion contracture (HP:0006380)1.87619403
83Nephroblastoma (Wilms tumor) (HP:0002667)1.86596842
84Selective tooth agenesis (HP:0001592)1.86179994
85Sacral dimple (HP:0000960)1.85146504
86* Omphalocele (HP:0001539)1.85029931
87Hypobetalipoproteinemia (HP:0003563)1.84643784
88Broad phalanx (HP:0006009)1.83871251
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83135972
90Protrusio acetabuli (HP:0003179)1.82643170
91Myokymia (HP:0002411)1.81978039
92Bifid scrotum (HP:0000048)1.81504533
93Embryonal renal neoplasm (HP:0011794)1.79922925
94Embryonal neoplasm (HP:0002898)1.79682471
95* Skull defect (HP:0001362)1.78771520
96Advanced eruption of teeth (HP:0006288)1.77124223
97Turricephaly (HP:0000262)1.76966135
98Periauricular skin pits (HP:0100277)1.76076691
99Preauricular pit (HP:0004467)1.76076691
100Hypoplastic labia majora (HP:0000059)1.76041213
101High anterior hairline (HP:0009890)1.75545181
102Joint contractures involving the joints of the feet (HP:0100492)1.75428220
103Flexion contracture of toe (HP:0005830)1.75428220
104* Abnormality of the nasolacrimal system (HP:0000614)1.75298607
105Short 1st metacarpal (HP:0010034)1.75154802
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75154802
107Meckel diverticulum (HP:0002245)1.74963060
108Vertebral clefting (HP:0008428)1.74426573
109Flat acetabular roof (HP:0003180)1.74413702
110Wrist flexion contracture (HP:0001239)1.73744346
111Broad palm (HP:0001169)1.73303577
112Epiphyseal dysplasia (HP:0002656)1.73092743
113Pancreatic islet-cell hyperplasia (HP:0004510)1.72619760
114Subacute progressive viral hepatitis (HP:0006572)1.72320186
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.72317460
116Trigonocephaly (HP:0000243)1.72245591
117Broad long bones (HP:0005622)1.71302315
118Limited hip movement (HP:0008800)1.70868487
119Premature rupture of membranes (HP:0001788)1.70539223
120Abnormal tarsal ossification (HP:0008369)1.69966913
121Chromsome breakage (HP:0040012)1.69516273
122Abnormality of carpal bone ossification (HP:0006257)1.69501896
123Vertebral arch anomaly (HP:0008438)1.69130421
124Focal motor seizures (HP:0011153)1.68787976
125Short humerus (HP:0005792)1.68112415
126Abnormality of the middle phalanges of the toes (HP:0010183)1.67945017
127Short hallux (HP:0010109)1.66672639
128* Abnormality of the lacrimal duct (HP:0011481)1.66536688
129Aqueductal stenosis (HP:0002410)1.66124141
130Abnormality of the parietal bone (HP:0002696)1.64166502
131Cortical dysplasia (HP:0002539)1.64042690
132Short middle phalanx of finger (HP:0005819)1.63481990
133Wide anterior fontanel (HP:0000260)1.63427729
134Prolonged QT interval (HP:0001657)1.63425467
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62820686
136Absent epiphyses (HP:0010577)1.62820686
137Abnormality of the calf musculature (HP:0001430)1.62589468
138Abnormality of the ileum (HP:0001549)1.62263274
139* Wide nose (HP:0000445)1.62136660
140Decreased lacrimation (HP:0000633)1.61705244
141Mixed hearing impairment (HP:0000410)1.60064559
142Thin ribs (HP:0000883)1.59232247
143Supernumerary spleens (HP:0009799)1.59225229
144Acanthocytosis (HP:0001927)1.58860368
145Hypolipoproteinemia (HP:0010981)1.56917362
146Osteomalacia (HP:0002749)1.56894552
147Transposition of the great arteries (HP:0001669)1.56784045
148Abnormal connection of the cardiac segments (HP:0011545)1.56784045
149Abnormal ventriculo-arterial connection (HP:0011563)1.56784045
150Abnormality of the phalanges of the hallux (HP:0010057)1.56589524
151Narrow palate (HP:0000189)1.56165737
152Broad distal phalanx of finger (HP:0009836)1.55920421
153* Absent eyelashes (HP:0000561)1.55806349
154Abnormal umbilical cord blood vessels (HP:0011403)1.55716136
155Single umbilical artery (HP:0001195)1.55716136
156Abnormality of the fetal cardiovascular system (HP:0010948)1.55716136
157Laryngomalacia (HP:0001601)1.54960283
158Hypoplastic left heart (HP:0004383)1.54495415
159Tubulointerstitial fibrosis (HP:0005576)1.53974754
160Ankyloglossia (HP:0010296)1.53849638
161Abnormality of incisor morphology (HP:0011063)1.53143951
162Ventricular fibrillation (HP:0001663)1.52751515
163Long clavicles (HP:0000890)1.52195717
164Abnormality of the labia majora (HP:0012881)1.51660515
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.51410824
166Skin pits (HP:0100276)1.49650429
167Coronal craniosynostosis (HP:0004440)1.49322125
168Bronchomalacia (HP:0002780)1.48533732
169Chorioretinal atrophy (HP:0000533)1.47647665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.18278848
2PRKD33.57673186
3LATS12.67895122
4FGFR42.65962795
5TNIK2.53722018
6BCR2.38963999
7TTK2.37866114
8STK38L2.34001378
9NTRK32.32021550
10CDC72.23705697
11EPHB22.17727289
12MKNK22.11815254
13SCYL22.02580211
14OBSCN1.90811343
15TSSK61.80063567
16KSR11.68737329
17TAF11.68663790
18SGK21.66660910
19FER1.63282984
20ICK1.62862174
21ERBB31.62745514
22PLK41.62215868
23MINK11.60859501
24EEF2K1.55382652
25PLK21.54721850
26SRPK11.54139393
27FGFR21.50995487
28NUAK11.50521432
29PBK1.49661549
30TYRO31.45868485
31BUB11.44974764
32CDC42BPA1.41476795
33LATS21.39938126
34PNCK1.38996553
35NEK21.38170687
36SGK4941.35694527
37SGK2231.35694527
38FGFR31.33811003
39MARK11.31915015
40ERBB41.31135899
41LMTK21.28092946
42DAPK21.25209863
43FGFR11.21409468
44SIK21.21283172
45SIK11.21104390
46SMG11.20383270
47MAPK131.19933271
48SGK31.19543012
49MET1.16888846
50MAP3K41.11394026
51PKN21.10097879
52FRK1.09587183
53INSRR1.08985606
54MAP3K91.08311915
55MAP3K21.05330974
56STK241.04073202
57WNK41.01933178
58PAK61.01185327
59PLK31.00167640
60TAOK20.99997191
61PAK30.99776586
62TAOK10.99756610
63PDGFRA0.99403347
64STK30.98120359
65NTRK10.96827373
66DDR20.96733733
67NTRK20.96295376
68KSR20.94133253
69STK380.91008225
70FLT30.89849807
71WNK10.87674180
72PRPF4B0.87587939
73PLK10.86930161
74SIK30.86865440
75BRD40.86600341
76DMPK0.85814303
77BRSK20.85075361
78PASK0.84971783
79CDK70.84815093
80ROCK10.83326825
81CAMKK10.83234381
82NLK0.81543975
83MAP3K100.81242889
84PTK60.80901372
85WNK30.80808622
86BRSK10.79075618
87NEK10.78974580
88PAK40.77634123
89PRKCH0.76439380
90WEE10.76273835
91RIPK10.75926358
92SGK10.75449081
93PTK20.75273486
94ERBB20.74666243
95STK390.74576624
96TIE10.74517646
97CAMK1G0.74160008
98ATM0.73574979
99AKT30.71889218
100CHEK20.71638739
101PIK3CA0.71243288
102BMX0.71175618
103CHEK10.69937936
104ATR0.67893085
105ALK0.67160707
106CSNK1E0.66520911
107CASK0.66428905
108BMPR1B0.66377878
109PTK2B0.65744662
110CDK50.65544041
111PRKCG0.65190657
112LIMK10.61227661
113MAPK100.61122491
114CSNK1G10.61006876
115MYLK0.60811893
116CAMK40.60183732
117ACVR1B0.59856557
118MKNK10.59170204
119TTN0.57911137
120DYRK20.57889840
121CDK10.55883600
122MELK0.54769110
123PRKCZ0.54252081
124CDK120.54133816
125PRKCE0.54050583
126EPHA20.54010932
127MAP3K70.53984022
128NME10.53427852
129ZAK0.52431531
130MAP2K70.52014204
131PRKDC0.51648700
132RPS6KA20.51414127
133AURKB0.51145294
134MAP2K10.50462762
135VRK20.50195158
136CAMK2A0.49359885
137OXSR10.49062907
138CDK20.47645762
139CAMK1D0.46884693
140RPS6KA30.45682600
141TRIB30.45671180
142EIF2AK20.45017953
143MST1R0.44803425
144DYRK30.44272743
145DYRK1A0.43409141
146CSNK1D0.41501776
147MAP2K40.41156903
148MTOR0.40792120
149MAP3K130.40165651
150CAMK10.38164960
151PDGFRB0.37608398
152CDK60.36689100
153GSK3B0.36205393
154MAPK80.35824666
155CSNK1A1L0.35822397

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.26881264
2Steroid biosynthesis_Homo sapiens_hsa001002.16810465
3Non-homologous end-joining_Homo sapiens_hsa034502.09090010
4Hedgehog signaling pathway_Homo sapiens_hsa043402.00930215
5Nicotine addiction_Homo sapiens_hsa050331.97368639
6Circadian entrainment_Homo sapiens_hsa047131.96763495
7Hippo signaling pathway_Homo sapiens_hsa043901.93837900
8Amphetamine addiction_Homo sapiens_hsa050311.91635102
9Long-term potentiation_Homo sapiens_hsa047201.89249119
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85172636
11Insulin secretion_Homo sapiens_hsa049111.84613775
12Dilated cardiomyopathy_Homo sapiens_hsa054141.81629503
13Melanogenesis_Homo sapiens_hsa049161.80640548
14Axon guidance_Homo sapiens_hsa043601.77908443
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74408337
16Cocaine addiction_Homo sapiens_hsa050301.70224459
17Vitamin digestion and absorption_Homo sapiens_hsa049771.68631787
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66175203
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63815093
20Olfactory transduction_Homo sapiens_hsa047401.61927521
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59308086
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59074230
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58785451
24Adherens junction_Homo sapiens_hsa045201.58149722
25Mismatch repair_Homo sapiens_hsa034301.56404111
26Dopaminergic synapse_Homo sapiens_hsa047281.55689768
27Tight junction_Homo sapiens_hsa045301.55671697
28Selenocompound metabolism_Homo sapiens_hsa004501.55638680
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54534726
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53827996
31GABAergic synapse_Homo sapiens_hsa047271.53248614
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.52771080
33RNA transport_Homo sapiens_hsa030131.50921191
34DNA replication_Homo sapiens_hsa030301.50642675
35mRNA surveillance pathway_Homo sapiens_hsa030151.49331963
36Cell cycle_Homo sapiens_hsa041101.49146370
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47554424
38Biosynthesis of amino acids_Homo sapiens_hsa012301.47156504
39Morphine addiction_Homo sapiens_hsa050321.46313799
40Complement and coagulation cascades_Homo sapiens_hsa046101.46246222
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44560101
42Glutamatergic synapse_Homo sapiens_hsa047241.44490205
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44089826
44Vitamin B6 metabolism_Homo sapiens_hsa007501.42796224
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42504080
46Renin secretion_Homo sapiens_hsa049241.39514385
47One carbon pool by folate_Homo sapiens_hsa006701.37775736
48Cholinergic synapse_Homo sapiens_hsa047251.36656168
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36442810
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36433328
51Endometrial cancer_Homo sapiens_hsa052131.33933571
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.33856613
53Cardiac muscle contraction_Homo sapiens_hsa042601.33852062
54Type II diabetes mellitus_Homo sapiens_hsa049301.33676033
55Wnt signaling pathway_Homo sapiens_hsa043101.32764783
56Gap junction_Homo sapiens_hsa045401.26521413
57Synaptic vesicle cycle_Homo sapiens_hsa047211.24168213
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23573747
59ECM-receptor interaction_Homo sapiens_hsa045121.22354228
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20891777
61TGF-beta signaling pathway_Homo sapiens_hsa043501.20832204
62Fat digestion and absorption_Homo sapiens_hsa049751.20310717
63Gastric acid secretion_Homo sapiens_hsa049711.18567830
64Spliceosome_Homo sapiens_hsa030401.18445825
65Oxytocin signaling pathway_Homo sapiens_hsa049211.15958934
66Thyroid hormone synthesis_Homo sapiens_hsa049181.13296084
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11904359
68Salivary secretion_Homo sapiens_hsa049701.09998001
69Glioma_Homo sapiens_hsa052141.09564032
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08049468
71Pyruvate metabolism_Homo sapiens_hsa006201.07306107
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06555117
73Oocyte meiosis_Homo sapiens_hsa041141.06008043
74Proteoglycans in cancer_Homo sapiens_hsa052051.06001394
75Taste transduction_Homo sapiens_hsa047421.05868890
76Fatty acid biosynthesis_Homo sapiens_hsa000611.05106066
77Butanoate metabolism_Homo sapiens_hsa006501.04979415
78GnRH signaling pathway_Homo sapiens_hsa049121.04514438
79Fatty acid metabolism_Homo sapiens_hsa012121.03220303
80cAMP signaling pathway_Homo sapiens_hsa040241.02089490
81Calcium signaling pathway_Homo sapiens_hsa040201.01666881
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00444412
83Long-term depression_Homo sapiens_hsa047300.99980695
84Glucagon signaling pathway_Homo sapiens_hsa049220.96844027
85Sulfur metabolism_Homo sapiens_hsa009200.96801787
86Focal adhesion_Homo sapiens_hsa045100.96172126
87Estrogen signaling pathway_Homo sapiens_hsa049150.95237546
88Arginine biosynthesis_Homo sapiens_hsa002200.93969418
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93283825
90Thyroid cancer_Homo sapiens_hsa052160.92437396
91N-Glycan biosynthesis_Homo sapiens_hsa005100.91743787
92Lysine degradation_Homo sapiens_hsa003100.90919862
93Rap1 signaling pathway_Homo sapiens_hsa040150.90326465
94Serotonergic synapse_Homo sapiens_hsa047260.89193816
95Arginine and proline metabolism_Homo sapiens_hsa003300.88758221
96Carbon metabolism_Homo sapiens_hsa012000.88685426
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87610768
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87601333
99Protein digestion and absorption_Homo sapiens_hsa049740.84695197
100Small cell lung cancer_Homo sapiens_hsa052220.84621578
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82956232
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81974270
103Base excision repair_Homo sapiens_hsa034100.79926052
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78781321
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77970642
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76713476
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76666390
108Prostate cancer_Homo sapiens_hsa052150.75434492
109Fatty acid degradation_Homo sapiens_hsa000710.75275745
110Non-small cell lung cancer_Homo sapiens_hsa052230.74944355
111ErbB signaling pathway_Homo sapiens_hsa040120.74619377
112MicroRNAs in cancer_Homo sapiens_hsa052060.74088178
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.73788428
114Nucleotide excision repair_Homo sapiens_hsa034200.72756094
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70904713
116Fanconi anemia pathway_Homo sapiens_hsa034600.69927905
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68786590
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68505073
119RNA degradation_Homo sapiens_hsa030180.66529248
120Bile secretion_Homo sapiens_hsa049760.66210250
121Basal transcription factors_Homo sapiens_hsa030220.65661995
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65528792
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65320672
124Starch and sucrose metabolism_Homo sapiens_hsa005000.64952989
125Dorso-ventral axis formation_Homo sapiens_hsa043200.64879545
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64195669
127Bladder cancer_Homo sapiens_hsa052190.62707890
128Renin-angiotensin system_Homo sapiens_hsa046140.62604923
129Alcoholism_Homo sapiens_hsa050340.62554331
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62306459
131Galactose metabolism_Homo sapiens_hsa000520.61794416
132Insulin signaling pathway_Homo sapiens_hsa049100.59432377
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.56672841
134mTOR signaling pathway_Homo sapiens_hsa041500.56143494
135Pathways in cancer_Homo sapiens_hsa052000.56037029
136RNA polymerase_Homo sapiens_hsa030200.54286515
137Colorectal cancer_Homo sapiens_hsa052100.53745478
138p53 signaling pathway_Homo sapiens_hsa041150.51554445
139Circadian rhythm_Homo sapiens_hsa047100.51287371
140Melanoma_Homo sapiens_hsa052180.51284175
141Insulin resistance_Homo sapiens_hsa049310.50392460
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50299499
143Histidine metabolism_Homo sapiens_hsa003400.50181006
144Homologous recombination_Homo sapiens_hsa034400.49315696
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48894588
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48745992
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47346418
148Nitrogen metabolism_Homo sapiens_hsa009100.47291126
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46948369
150Pancreatic secretion_Homo sapiens_hsa049720.46399335
151MAPK signaling pathway_Homo sapiens_hsa040100.45976167
152FoxO signaling pathway_Homo sapiens_hsa040680.45841857
153Ovarian steroidogenesis_Homo sapiens_hsa049130.44874088
154Propanoate metabolism_Homo sapiens_hsa006400.43922624
155Amoebiasis_Homo sapiens_hsa051460.42951044
156AMPK signaling pathway_Homo sapiens_hsa041520.35822828
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.34753139

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