FRAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.55623678
2negative regulation of cell killing (GO:0031342)6.55623678
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54470225
4DNA deamination (GO:0045006)6.22674414
5positive regulation by symbiont of host defense response (GO:0052509)6.19722498
6modulation by symbiont of host defense response (GO:0052031)6.19722498
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.19722498
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.19722498
9positive regulation by organism of defense response of other organism involved in symbiotic interact6.19722498
10modulation by symbiont of host immune response (GO:0052553)6.19722498
11positive regulation of gamma-delta T cell activation (GO:0046645)5.85507207
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.62213013
13neutrophil activation involved in immune response (GO:0002283)5.56769879
14antigen processing and presentation of endogenous antigen (GO:0019883)5.54056641
15detection of other organism (GO:0098543)5.40413748
16detection of bacterium (GO:0016045)5.15442426
17macrophage activation involved in immune response (GO:0002281)5.03143788
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00880291
19response to peptidoglycan (GO:0032494)4.91398713
20regulation of B cell receptor signaling pathway (GO:0050855)4.90858549
21leukocyte aggregation (GO:0070486)4.86440068
22leukocyte migration involved in inflammatory response (GO:0002523)4.73204545
23detection of external biotic stimulus (GO:0098581)4.71220093
24cellular extravasation (GO:0045123)4.70527319
25detection of molecule of bacterial origin (GO:0032490)4.68365195
26proteasome assembly (GO:0043248)4.51613739
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.47120186
28neutrophil activation (GO:0042119)4.46234158
29respiratory burst (GO:0045730)4.41631315
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.28521967
31negative regulation of interleukin-12 production (GO:0032695)4.28402280
32regulation of gamma-delta T cell activation (GO:0046643)4.25333962
33regulation of interferon-beta biosynthetic process (GO:0045357)4.22389172
34response to interleukin-15 (GO:0070672)4.20853738
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19924368
36response to host immune response (GO:0052572)4.19183347
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.19183347
38detection of biotic stimulus (GO:0009595)4.14379356
39microglial cell activation (GO:0001774)4.12889053
40ribosomal small subunit assembly (GO:0000028)4.04516241
41granulocyte activation (GO:0036230)4.01725003
42neutrophil mediated immunity (GO:0002446)3.95922768
43negative regulation of leukocyte mediated immunity (GO:0002704)3.92479334
44regulation of mast cell degranulation (GO:0043304)3.91360809
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.89171403
46response to host (GO:0075136)3.86184750
47response to host defenses (GO:0052200)3.86184750
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86184750
49respiratory chain complex IV assembly (GO:0008535)3.86017732
50cellular response to interleukin-15 (GO:0071350)3.82577842
51myeloid cell activation involved in immune response (GO:0002275)3.82323427
52macrophage activation (GO:0042116)3.82262902
53immunoglobulin mediated immune response (GO:0016064)3.81946445
54DNA ligation (GO:0006266)3.80644113
55regulation of gamma-delta T cell differentiation (GO:0045586)3.78841979
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.70992939
57negative regulation of T cell mediated immunity (GO:0002710)3.70451064
58negative regulation of erythrocyte differentiation (GO:0045647)3.68998243
59postsynaptic membrane organization (GO:0001941)3.65422861
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.65069756
61positive regulation of mast cell activation (GO:0033005)3.59757970
62regulation of mast cell activation involved in immune response (GO:0033006)3.57715064
63antigen processing and presentation via MHC class Ib (GO:0002475)3.55654412
64termination of RNA polymerase III transcription (GO:0006386)3.54047694
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.54047694
66B cell receptor signaling pathway (GO:0050853)3.53213189
67regulation of leukocyte degranulation (GO:0043300)3.53018784
68sperm motility (GO:0030317)3.52027099
69production of molecular mediator involved in inflammatory response (GO:0002532)3.51339797
70presynaptic membrane assembly (GO:0097105)3.45381049
71microtubule depolymerization (GO:0007019)3.41763010
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.41531289
73response to muramyl dipeptide (GO:0032495)3.40973202
74leukocyte degranulation (GO:0043299)3.38766167
75myeloid leukocyte mediated immunity (GO:0002444)3.37547321
76regulation of mast cell activation (GO:0033003)3.36713049
77negative regulation of phagocytosis (GO:0050765)3.35284010
78cellular response to type I interferon (GO:0071357)3.34905707
79type I interferon signaling pathway (GO:0060337)3.34905707
80GTP biosynthetic process (GO:0006183)3.34300959
81regulation of B cell differentiation (GO:0045577)3.34233559
82acrosome reaction (GO:0007340)3.33903285
83epithelial cilium movement (GO:0003351)3.33841462
84viral transcription (GO:0019083)3.33286888
85response to type I interferon (GO:0034340)3.32080878
86cytochrome complex assembly (GO:0017004)3.26895898
87telomere maintenance via semi-conservative replication (GO:0032201)3.25972632
88mannosylation (GO:0097502)3.25346539
89ribosomal large subunit biogenesis (GO:0042273)3.24207152
90regulation of tolerance induction (GO:0002643)3.23607305
91regulation of T cell tolerance induction (GO:0002664)3.23339909
92ribosomal small subunit biogenesis (GO:0042274)3.22839445
93positive regulation of B cell differentiation (GO:0045579)3.22690728
94defense response to protozoan (GO:0042832)3.17870804
95regulation of T-helper 2 cell differentiation (GO:0045628)3.16161539
96regulation of regulated secretory pathway (GO:1903305)3.16018399
97GMP metabolic process (GO:0046037)3.14968538
98positive thymic T cell selection (GO:0045059)3.14016948
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11588788
100negative regulation of T-helper cell differentiation (GO:0045623)3.11588788
101negative regulation of interleukin-6 production (GO:0032715)3.11321555
102acrosome assembly (GO:0001675)3.11162697
103translational termination (GO:0006415)3.10570288
104cell wall macromolecule metabolic process (GO:0044036)3.09575926
105cell wall macromolecule catabolic process (GO:0016998)3.09575926
106germinal center formation (GO:0002467)3.09475921
107negative thymic T cell selection (GO:0045060)3.08536835
108tolerance induction (GO:0002507)3.08137211
109activated T cell proliferation (GO:0050798)3.07241014
110positive regulation of mast cell activation involved in immune response (GO:0033008)3.06304815
111positive regulation of mast cell degranulation (GO:0043306)3.06304815
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03724076
113negative T cell selection (GO:0043383)3.00936263
114negative regulation of innate immune response (GO:0045824)3.00499980
115pseudouridine synthesis (GO:0001522)3.00468984
116metallo-sulfur cluster assembly (GO:0031163)3.00170060
117iron-sulfur cluster assembly (GO:0016226)3.00170060
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.98930636
119dendritic cell migration (GO:0036336)2.98414079
120B cell mediated immunity (GO:0019724)2.98178318
121negative regulation of type 2 immune response (GO:0002829)2.97881832
122generation of neurons (GO:0048699)2.97440543
123regulation of T cell mediated cytotoxicity (GO:0001914)2.96498075
124axonemal dynein complex assembly (GO:0070286)2.96335514
125positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94494938
126chaperone-mediated protein transport (GO:0072321)2.93175099
127protein complex biogenesis (GO:0070271)2.92823579
128lymphoid progenitor cell differentiation (GO:0002320)2.92669287
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92528163
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91896914
131guanosine-containing compound biosynthetic process (GO:1901070)2.91446161
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91359155
133presynaptic membrane organization (GO:0097090)2.91120831
134interferon-gamma-mediated signaling pathway (GO:0060333)2.91061391
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90813427
136negative regulation of transcription by competitive promoter binding (GO:0010944)2.90743610
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.90280566
138NADH dehydrogenase complex assembly (GO:0010257)2.90280566
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90280566
140dendritic cell chemotaxis (GO:0002407)2.90254020
141negative regulation of execution phase of apoptosis (GO:1900118)2.89184049
142negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87668767
143cotranslational protein targeting to membrane (GO:0006613)2.87588496
144myeloid leukocyte activation (GO:0002274)2.87270466
145tRNA methylation (GO:0030488)2.85396408
146telomere maintenance via recombination (GO:0000722)2.84844202
147spermatid nucleus differentiation (GO:0007289)2.82506179
148sperm-egg recognition (GO:0035036)2.82166551
149protein targeting to ER (GO:0045047)2.81897778
150multicellular organism reproduction (GO:0032504)2.81531031
151pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80878010
152sequestering of actin monomers (GO:0042989)2.80258454
153DNA strand elongation involved in DNA replication (GO:0006271)2.77493885
154regulation of pigment cell differentiation (GO:0050932)2.76764689
155protein localization to endoplasmic reticulum (GO:0070972)2.75173629
156motile cilium assembly (GO:0044458)2.73365521
157regulation of cilium movement (GO:0003352)2.71560382
158DNA strand elongation (GO:0022616)2.70055641
159omega-hydroxylase P450 pathway (GO:0097267)2.69809928
160maturation of 5.8S rRNA (GO:0000460)2.68049452
161tRNA modification (GO:0006400)2.66640910
1627-methylguanosine mRNA capping (GO:0006370)2.66156712
163translational elongation (GO:0006414)2.65789035
164fusion of sperm to egg plasma membrane (GO:0007342)2.64237783
1652-deoxyribonucleotide biosynthetic process (GO:0009265)2.63943961
166deoxyribose phosphate biosynthetic process (GO:0046385)2.63943961
167maturation of SSU-rRNA (GO:0030490)2.63196392
168CTP metabolic process (GO:0046036)2.62880266
169CTP biosynthetic process (GO:0006241)2.62880266
1707-methylguanosine RNA capping (GO:0009452)2.62737553
171RNA capping (GO:0036260)2.62737553
172UTP biosynthetic process (GO:0006228)2.61222022
173ribonucleoprotein complex biogenesis (GO:0022613)2.60543840
174mitochondrial respiratory chain complex assembly (GO:0033108)2.60121319
175establishment of protein localization to endoplasmic reticulum (GO:0072599)2.59526518
176cellular protein complex disassembly (GO:0043624)2.57787146
177nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57274607
178centriole assembly (GO:0098534)2.57084332
179sympathetic nervous system development (GO:0048485)2.56701463
180pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56563090
181exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56130731
182deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56065796
183facial nerve structural organization (GO:0021612)2.55360530
184cilium movement (GO:0003341)2.54907666
185cellular component biogenesis (GO:0044085)2.54473096
186dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.54271547
187spermatid development (GO:0007286)2.52795763
188mitochondrion degradation (GO:0000422)2.52338412
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51825343
190binding of sperm to zona pellucida (GO:0007339)2.49913021
191tRNA processing (GO:0008033)2.48209461
192cullin deneddylation (GO:0010388)2.47523199
193viral genome replication (GO:0019079)2.46476118
194viral life cycle (GO:0019058)2.46403671
195cell-cell recognition (GO:0009988)2.46354446
196DNA replication initiation (GO:0006270)2.43050964
197response to folic acid (GO:0051593)2.43048140
198platelet dense granule organization (GO:0060155)2.42842150
199translation (GO:0006412)2.42167318
200neuronal action potential propagation (GO:0019227)2.41899532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.86139420
2EZH2_22144423_ChIP-Seq_EOC_Human4.69273089
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.40158237
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.23150156
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.81809208
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54406201
7VDR_21846776_ChIP-Seq_THP-1_Human3.36782532
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.27154625
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23294283
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19360920
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12756316
12* VDR_24763502_ChIP-Seq_THP-1_Human2.95030513
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92595049
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.90569240
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85936155
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84769522
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83681326
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79102591
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68639647
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64734253
21RUNX_20019798_ChIP-Seq_JUKART_Human2.59154835
22SPI1_23127762_ChIP-Seq_K562_Human2.59057687
23MAF_26560356_Chip-Seq_TH1_Human2.58558661
24MYC_22102868_ChIP-Seq_BL_Human2.55923343
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51823766
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.47232342
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.40101185
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.37723699
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37254035
30UTX_26944678_Chip-Seq_JUKART_Human2.33676910
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32527132
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31546646
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29840657
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29446708
35TCF7_22412390_ChIP-Seq_EML_Mouse2.28425254
36MYB_26560356_Chip-Seq_TH2_Human2.23947580
37E2F7_22180533_ChIP-Seq_HELA_Human2.22669199
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22615737
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20364598
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19911886
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17104129
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14528392
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14502508
44FLI1_27457419_Chip-Seq_LIVER_Mouse2.07096025
45* KDM2B_26808549_Chip-Seq_DND41_Human2.04028148
46MYB_26560356_Chip-Seq_TH1_Human2.03607340
47EGR1_19374776_ChIP-ChIP_THP-1_Human2.03149112
48NOTCH1_21737748_ChIP-Seq_TLL_Human2.02763897
49PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01558937
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.99789312
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97227339
52* MAF_26560356_Chip-Seq_TH2_Human1.94590848
53* YY1_21170310_ChIP-Seq_MESCs_Mouse1.85882804
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.85319584
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84236160
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83931759
57VDR_23849224_ChIP-Seq_CD4+_Human1.83694683
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.81059244
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75061530
60* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74585320
61IRF1_19129219_ChIP-ChIP_H3396_Human1.74117538
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72076705
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71842839
64TAF15_26573619_Chip-Seq_HEK293_Human1.71223506
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66353820
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65668370
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64445391
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64200089
69VDR_24787735_ChIP-Seq_THP-1_Human1.64101311
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.63601954
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.62645720
72* FOXP3_21729870_ChIP-Seq_TREG_Human1.62411222
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58613854
74GATA3_27048872_Chip-Seq_THYMUS_Human1.57858105
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57365968
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56720866
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.54412846
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54338163
79LXR_22292898_ChIP-Seq_THP-1_Human1.52054515
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51713902
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51415514
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47143835
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45365143
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44425208
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.42953565
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41374609
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41313614
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41298812
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41289947
90* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41238987
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40481227
92* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40174075
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39990096
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39071308
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.38633124
96* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38528709
97RNF2_27304074_Chip-Seq_NSC_Mouse1.38348929
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37094604
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33829150
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32310608
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32055992
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31612348
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31144055
104GBX2_23144817_ChIP-Seq_PC3_Human1.30265995
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30193973
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29783537
107* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29095254
108TTF2_22483619_ChIP-Seq_HELA_Human1.28498289
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28338738
110PU_27001747_Chip-Seq_BMDM_Mouse1.28314248
111MYC_18940864_ChIP-ChIP_HL60_Human1.24570701
112GATA1_19941826_ChIP-Seq_K562_Human1.24185732
113* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23791632
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22829426
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22707594
116BCL6_27268052_Chip-Seq_Bcells_Human1.22456567
117DCP1A_22483619_ChIP-Seq_HELA_Human1.22079293
118* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22053640
119* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21406192
120* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19970612
121* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18707325
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17943691
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17718018
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17609159
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16366657
126* BCOR_27268052_Chip-Seq_Bcells_Human1.14357723
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13965564
128GATA3_26560356_Chip-Seq_TH2_Human1.13467569
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12902876
130* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12711813
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11763008
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11079739
133* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10472064
134SCL_19346495_ChIP-Seq_HPC-7_Human1.07937419
135* GATA3_21867929_ChIP-Seq_CD8_Mouse1.07766781
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.04847884
137GABP_19822575_ChIP-Seq_HepG2_Human1.04841310
138NCOR1_26117541_ChIP-Seq_K562_Human1.03845073
139ELK1_19687146_ChIP-ChIP_HELA_Human1.03542202
140XRN2_22483619_ChIP-Seq_HELA_Human1.03064159
141STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02841178
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02018525
143* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01921919
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01758245
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01338863
146P53_22387025_ChIP-Seq_ESCs_Mouse1.00657543
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00630807
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99899726
149STAT3_18555785_Chip-Seq_ESCs_Mouse0.99135160
150VDR_22108803_ChIP-Seq_LS180_Human0.98810637
151* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98155080
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.97490091
153LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97316403
154SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96743803
155* RACK7_27058665_Chip-Seq_MCF-7_Human0.96553783
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96541303
157P300_18555785_Chip-Seq_ESCs_Mouse0.96328616
158GATA2_19941826_ChIP-Seq_K562_Human0.96162870
159IGF1R_20145208_ChIP-Seq_DFB_Human0.94392526
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94228310
161KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93197497
162* SPI1_23547873_ChIP-Seq_NB4_Human0.91522177
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91336094
164CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91135840
165* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90830249
166FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89744174
167KDM2B_26808549_Chip-Seq_K562_Human0.89714304
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.89454512
169POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89194340
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.88994413
171TAL1_26923725_Chip-Seq_HPCs_Mouse0.87804237
172* P68_20966046_ChIP-Seq_HELA_Human0.87624328
173TP63_19390658_ChIP-ChIP_HaCaT_Human0.87550310
174CRX_20693478_ChIP-Seq_RETINA_Mouse0.87530944
175GATA1_22025678_ChIP-Seq_K562_Human0.86918644
176* SPI1_20517297_ChIP-Seq_HL60_Human0.86909647
177POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86772841
178ELF1_20517297_ChIP-Seq_JURKAT_Human0.86346658
179MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85327008
180CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84145727
181POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84002222
182KLF4_18555785_Chip-Seq_ESCs_Mouse0.83407326
183OCT4_18555785_Chip-Seq_ESCs_Mouse0.83206493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.47208707
2MP0003436_decreased_susceptibility_to4.46844990
3MP0006292_abnormal_olfactory_placode3.67975805
4MP0001188_hyperpigmentation3.64487144
5MP0002419_abnormal_innate_immunity3.23497147
6MP0005410_abnormal_fertilization2.94418250
7MP0003136_yellow_coat_color2.93764886
8MP0001790_abnormal_immune_system2.67436869
9MP0005387_immune_system_phenotype2.67436869
10MP0000685_abnormal_immune_system2.64791372
11MP0005409_darkened_coat_color2.63248321
12MP0000015_abnormal_ear_pigmentation2.56829287
13MP0003724_increased_susceptibility_to2.51282558
14MP0006082_CNS_inflammation2.50042303
15MP0003300_gastrointestinal_ulcer2.44729410
16MP0002452_abnormal_antigen_presenting2.44680864
17MP0001986_abnormal_taste_sensitivity2.44527862
18MP0003191_abnormal_cellular_cholesterol2.44050412
19MP0005174_abnormal_tail_pigmentation2.35426879
20MP0003880_abnormal_central_pattern2.33421061
21MP0005075_abnormal_melanosome_morpholog2.31883214
22MP0001533_abnormal_skeleton_physiology2.18553612
23MP0008058_abnormal_DNA_repair2.15354336
24MP0005464_abnormal_platelet_physiology2.14334491
25MP0004381_abnormal_hair_follicle2.11521744
26MP0002405_respiratory_system_inflammati2.02396836
27MP0009278_abnormal_bone_marrow1.97330394
28MP0003828_pulmonary_edema1.94482311
29MP0003172_abnormal_lysosome_physiology1.94430607
30MP0000372_irregular_coat_pigmentation1.92211903
31MP0003786_premature_aging1.91295534
32MP0002095_abnormal_skin_pigmentation1.85203983
33MP0003763_abnormal_thymus_physiology1.78187537
34MP0008260_abnormal_autophagy1.76938367
35MP0008789_abnormal_olfactory_epithelium1.75599901
36MP0002876_abnormal_thyroid_physiology1.75493766
37MP0010155_abnormal_intestine_physiology1.75276084
38MP0002009_preneoplasia1.73499498
39MP0001845_abnormal_inflammatory_respons1.68823803
40MP0002722_abnormal_immune_system1.67022947
41MP0002132_abnormal_respiratory_system1.65425446
42MP0003183_abnormal_peptide_metabolism1.63929208
43MP0008007_abnormal_cellular_replicative1.61507775
44MP0004947_skin_inflammation1.61148111
45MP0000703_abnormal_thymus_morphology1.56082254
46MP0008995_early_reproductive_senescence1.55394972
47MP0002102_abnormal_ear_morphology1.54784007
48MP0005451_abnormal_body_composition1.53958885
49MP0002429_abnormal_blood_cell1.53935357
50MP0003698_abnormal_male_reproductive1.53268233
51MP0008877_abnormal_DNA_methylation1.49020805
52MP0004883_abnormal_blood_vessel1.48880940
53MP0010094_abnormal_chromosome_stability1.46872631
54MP0008469_abnormal_protein_level1.45454808
55MP0002277_abnormal_respiratory_mucosa1.44879096
56MP0004142_abnormal_muscle_tone1.44400236
57MP0005394_taste/olfaction_phenotype1.42597134
58MP0005499_abnormal_olfactory_system1.42597134
59MP0000566_synostosis1.42219172
60MP0001929_abnormal_gametogenesis1.40352791
61MP0005397_hematopoietic_system_phenotyp1.39475537
62MP0001545_abnormal_hematopoietic_system1.39475537
63MP0009764_decreased_sensitivity_to1.38545177
64MP0001851_eye_inflammation1.37593189
65MP0009333_abnormal_splenocyte_physiolog1.37581398
66MP0000858_altered_metastatic_potential1.36225973
67MP0002160_abnormal_reproductive_system1.35897676
68MP0005310_abnormal_salivary_gland1.35109595
69MP0006276_abnormal_autonomic_nervous1.34433480
70MP0002638_abnormal_pupillary_reflex1.33892424
71MP0005671_abnormal_response_to1.33813274
72MP0003938_abnormal_ear_development1.28949199
73MP0001984_abnormal_olfaction1.25207160
74MP0000465_gastrointestinal_hemorrhage1.21838540
75MP0002210_abnormal_sex_determination1.18804068
76MP0001835_abnormal_antigen_presentation1.17251329
77MP0003693_abnormal_embryo_hatching1.16698851
78MP0004510_myositis1.15596583
79MP0001905_abnormal_dopamine_level1.15583925
80MP0003718_maternal_effect1.15394266
81MP0003646_muscle_fatigue1.14107136
82MP0002751_abnormal_autonomic_nervous1.13874572
83MP0002998_abnormal_bone_remodeling1.13651837
84MP0003879_abnormal_hair_cell1.12102251
85MP0000049_abnormal_middle_ear1.11279731
86MP0003075_altered_response_to1.10781103
87MP0001968_abnormal_touch/_nociception1.09244293
88MP0005423_abnormal_somatic_nervous1.09028978
89MP0009785_altered_susceptibility_to1.08182493
90MP0005164_abnormal_response_to1.07712587
91MP0002148_abnormal_hypersensitivity_rea1.07223611
92MP0005058_abnormal_lysosome_morphology1.05968183
93MP0002396_abnormal_hematopoietic_system1.05081759
94MP0000490_abnormal_crypts_of1.04073969
95MP0003690_abnormal_glial_cell1.03550756
96MP0002735_abnormal_chemical_nociception1.03180147
97MP0004147_increased_porphyrin_level1.02585293
98MP0002166_altered_tumor_susceptibility1.02410457
99MP0000631_abnormal_neuroendocrine_gland1.01743259
100MP0001919_abnormal_reproductive_system1.00810950
101MP0000681_abnormal_thyroid_gland1.00387554
102MP0005084_abnormal_gallbladder_morpholo0.99963416
103MP0004742_abnormal_vestibular_system0.96454374
104MP0001529_abnormal_vocalization0.96372296
105MP0002398_abnormal_bone_marrow0.95902048
106MP0002272_abnormal_nervous_system0.95042834
107MP0002177_abnormal_outer_ear0.94833490
108MP0002420_abnormal_adaptive_immunity0.94489250
109MP0001145_abnormal_male_reproductive0.92662632
110MP0000026_abnormal_inner_ear0.92503005
111MP0001819_abnormal_immune_cell0.92196939
112MP0005000_abnormal_immune_tolerance0.92171578
113MP0008004_abnormal_stomach_pH0.91230694
114MP0002736_abnormal_nociception_after0.91021403
115MP0003011_delayed_dark_adaptation0.89629510
116MP0003656_abnormal_erythrocyte_physiolo0.89121611
117MP0001663_abnormal_digestive_system0.88143040
118MP0002938_white_spotting0.87674880
119MP0005166_decreased_susceptibility_to0.87416231
120MP0004808_abnormal_hematopoietic_stem0.86808517
121MP0002163_abnormal_gland_morphology0.86751877
122MP0000653_abnormal_sex_gland0.86637160
123MP0005025_abnormal_response_to0.86237785
124MP0002723_abnormal_immune_serum0.86077972
125MP0000689_abnormal_spleen_morphology0.85877621
126MP0005389_reproductive_system_phenotype0.85840150
127MP0005390_skeleton_phenotype0.85535692
128MP0005083_abnormal_biliary_tract0.84896098
129MP0001873_stomach_inflammation0.84702680
130MP0005551_abnormal_eye_electrophysiolog0.83987876
131MP0008057_abnormal_DNA_replication0.83493228
132MP0002557_abnormal_social/conspecific_i0.82779171
133MP0002067_abnormal_sensory_capabilities0.82581137
134MP0003315_abnormal_perineum_morphology0.82135305
135MP0008932_abnormal_embryonic_tissue0.81719176
136MP0005646_abnormal_pituitary_gland0.81551675
137MP0003303_peritoneal_inflammation0.81046694
138MP0004130_abnormal_muscle_cell0.80988529
139MP0000716_abnormal_immune_system0.80637667
140MP0005171_absent_coat_pigmentation0.80308764
141MP0009763_increased_sensitivity_to0.77970512
142MP0003866_abnormal_defecation0.76609707
143MP0001800_abnormal_humoral_immune0.75003298
144MP0003448_altered_tumor_morphology0.74850891
145MP0009046_muscle_twitch0.74236309
146MP0009745_abnormal_behavioral_response0.73981117
147MP0003077_abnormal_cell_cycle0.73975727
148MP0001963_abnormal_hearing_physiology0.73479466
149MP0001486_abnormal_startle_reflex0.73392837
150MP0003806_abnormal_nucleotide_metabolis0.72326099
151MP0002928_abnormal_bile_duct0.72010222
152MP0000343_altered_response_to0.71156142
153MP0009765_abnormal_xenobiotic_induced0.70071192
154MP0000604_amyloidosis0.68919847
155MP0003221_abnormal_cardiomyocyte_apopto0.68854046
156MP0005377_hearing/vestibular/ear_phenot0.68192638
157MP0003878_abnormal_ear_physiology0.68192638
158MP0001853_heart_inflammation0.68078130
159MP0008874_decreased_physiological_sensi0.66289128
160MP0002933_joint_inflammation0.62124397
161MP0005319_abnormal_enzyme/_coenzyme0.60796868
162MP0003045_fibrosis0.60707093
163MP0003795_abnormal_bone_structure0.58962150
164MP0000249_abnormal_blood_vessel0.58695593
165MP0002138_abnormal_hepatobiliary_system0.58179906
166MP0002006_tumorigenesis0.55407214
167MP0005248_abnormal_Harderian_gland0.55239851
168MP0005076_abnormal_cell_differentiation0.55106950
169MP0002133_abnormal_respiratory_system0.54858714
170MP0005388_respiratory_system_phenotype0.54858714
171MP0000470_abnormal_stomach_morphology0.53582014

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.08338397
2Recurrent abscess formation (HP:0002722)6.37861003
3Recurrent bacterial skin infections (HP:0005406)6.23537481
4Myositis (HP:0100614)5.95821868
5Abnormality of macrophages (HP:0004311)5.48954220
6Orchitis (HP:0100796)5.48076472
7Recurrent gram-negative bacterial infections (HP:0005420)5.25578721
8Retrobulbar optic neuritis (HP:0100654)5.10883373
9Optic neuritis (HP:0100653)5.10883373
10Elevated erythrocyte sedimentation rate (HP:0003565)4.74887946
11Hypochromic microcytic anemia (HP:0004840)4.63726926
12Gastrointestinal infarctions (HP:0005244)4.48843454
13Type I transferrin isoform profile (HP:0003642)4.46968837
14Recurrent fungal infections (HP:0002841)4.25377332
15Reduced antithrombin III activity (HP:0001976)4.16708254
16Recurrent skin infections (HP:0001581)4.12509786
17Mediastinal lymphadenopathy (HP:0100721)4.12310396
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.09361712
19Hypochromic anemia (HP:0001931)3.91052997
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.87993464
21Absent/shortened dynein arms (HP:0200106)3.87993464
22Encephalitis (HP:0002383)3.81152803
23Abnormal number of erythroid precursors (HP:0012131)3.79808995
24Spontaneous hematomas (HP:0007420)3.75362322
25Gingivitis (HP:0000230)3.72915961
26Keratoconjunctivitis sicca (HP:0001097)3.71707544
27Increased IgE level (HP:0003212)3.68703879
28Recurrent cutaneous fungal infections (HP:0011370)3.67355095
29Chronic mucocutaneous candidiasis (HP:0002728)3.67355095
30Prolonged bleeding time (HP:0003010)3.63214067
31Urticaria (HP:0001025)3.62506682
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.61906197
33Absent rod-and cone-mediated responses on ERG (HP:0007688)3.58505710
34Abnormality of cells of the erythroid lineage (HP:0012130)3.57205297
35Keratoconjunctivitis (HP:0001096)3.45785077
36Cellulitis (HP:0100658)3.43843568
37Vasculitis (HP:0002633)3.33742297
38Chest pain (HP:0100749)3.33632025
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.29743590
40Type 2 muscle fiber atrophy (HP:0003554)3.28694145
41Episodic fever (HP:0001954)3.18885461
423-Methylglutaconic aciduria (HP:0003535)3.16822940
43Gingival bleeding (HP:0000225)3.16531884
44Abnormal respiratory epithelium morphology (HP:0012253)3.15536783
45Abnormal respiratory motile cilium morphology (HP:0005938)3.15536783
46Severe visual impairment (HP:0001141)3.11872436
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00007015
48Abnormal protein N-linked glycosylation (HP:0012347)3.00007015
49Abnormal protein glycosylation (HP:0012346)3.00007015
50Abnormal glycosylation (HP:0012345)3.00007015
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96427414
52Arterial thrombosis (HP:0004420)2.93329038
53Muscle fiber atrophy (HP:0100295)2.93305405
54Epistaxis (HP:0000421)2.92041675
55Increased hepatocellular lipid droplets (HP:0006565)2.91630727
56Peritonitis (HP:0002586)2.90765217
57Hepatocellular necrosis (HP:0001404)2.89174747
58Hemoptysis (HP:0002105)2.86592328
59Hypothermia (HP:0002045)2.85213513
60Inflammation of the large intestine (HP:0002037)2.84417629
61Microcytic anemia (HP:0001935)2.81112112
62Anorexia (HP:0002039)2.79753378
63Gastrointestinal inflammation (HP:0004386)2.78588771
64T lymphocytopenia (HP:0005403)2.74809564
65Amyloidosis (HP:0011034)2.73327335
66Mitochondrial inheritance (HP:0001427)2.73231611
67Renal Fanconi syndrome (HP:0001994)2.72414958
68Pulmonary infiltrates (HP:0002113)2.72299043
69True hermaphroditism (HP:0010459)2.72098572
70Leukocytosis (HP:0001974)2.71787659
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71498573
72Pulmonary embolism (HP:0002204)2.71184043
73Aplastic anemia (HP:0001915)2.64387004
74Abnormality of T cell number (HP:0011839)2.63177172
75Recurrent viral infections (HP:0004429)2.60433505
76Reticulocytopenia (HP:0001896)2.60302288
77Pustule (HP:0200039)2.60167397
78Osteomyelitis (HP:0002754)2.58284488
79Abnormal rod and cone electroretinograms (HP:0008323)2.56161049
80Thyroid-stimulating hormone excess (HP:0002925)2.55698606
81Attenuation of retinal blood vessels (HP:0007843)2.54286352
82Exertional dyspnea (HP:0002875)2.50707498
83Abnormal spermatogenesis (HP:0008669)2.50277412
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49496623
85Abnormality of T cells (HP:0002843)2.49293251
86Abnormality of the preputium (HP:0100587)2.43985794
87Granulocytopenia (HP:0001913)2.42849834
88Increased IgM level (HP:0003496)2.42669640
89Optic disc pallor (HP:0000543)2.40965761
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.38307943
91Abnormal ciliary motility (HP:0012262)2.37339064
92Sepsis (HP:0100806)2.37084586
93Abnormal respiratory motile cilium physiology (HP:0012261)2.34087003
94Lipid accumulation in hepatocytes (HP:0006561)2.32160367
95Focal motor seizures (HP:0011153)2.30088808
96Chromsome breakage (HP:0040012)2.28324011
97Optic nerve hypoplasia (HP:0000609)2.28115206
98Purpura (HP:0000979)2.27089066
99Abnormality of the peritoneum (HP:0002585)2.26231480
100Nonprogressive disorder (HP:0003680)2.25277023
101Abnormal platelet volume (HP:0011876)2.25068452
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24915727
103Abnormality of the pleura (HP:0002103)2.24480909
104Lymphopenia (HP:0001888)2.24229722
105Febrile seizures (HP:0002373)2.24061305
106Hepatic necrosis (HP:0002605)2.24025562
107Colitis (HP:0002583)2.23034303
108Respiratory difficulties (HP:0002880)2.22752761
109Gangrene (HP:0100758)2.22075178
110Acute necrotizing encephalopathy (HP:0006965)2.20236479
111Increased CSF lactate (HP:0002490)2.19744876
112Abnormality of T cell physiology (HP:0011840)2.19463626
113Decreased central vision (HP:0007663)2.18356073
114Pancreatic fibrosis (HP:0100732)2.14078472
115Slow saccadic eye movements (HP:0000514)2.13105113
116Increased serum ferritin (HP:0003281)2.11422741
117Abnormality of the septum pellucidum (HP:0007375)2.10433755
118Increased intramyocellular lipid droplets (HP:0012240)2.09216661
119Abnormality of iron homeostasis (HP:0011031)2.09197490
120Clubbing of toes (HP:0100760)2.08738003
121Abnormality of secondary sexual hair (HP:0009888)2.08433290
122Abnormality of the axillary hair (HP:0100134)2.08433290
123Abnormality of cells of the lymphoid lineage (HP:0012140)2.08374909
124Glomerulopathy (HP:0100820)2.08134080
125Pancreatic cysts (HP:0001737)2.07984295
126Meckel diverticulum (HP:0002245)2.07844928
127Hypergammaglobulinemia (HP:0010702)2.07629740
128Polycythemia (HP:0001901)2.06987379
129Hepatosplenomegaly (HP:0001433)2.06296166
130Abnormality of the endocardium (HP:0004306)2.05909026
131Skin ulcer (HP:0200042)2.05070454
132Vertigo (HP:0002321)2.03368928
133Dry hair (HP:0011359)2.03221665
134Abnormality of the ileum (HP:0001549)2.03038708
135Microvesicular hepatic steatosis (HP:0001414)2.02271695
136Petechiae (HP:0000967)2.00556644
137Increased serum lactate (HP:0002151)2.00177317
138Aplasia/Hypoplasia of the uvula (HP:0010293)2.00057265
139Acne (HP:0001061)2.00017918
140Pallor (HP:0000980)1.99101214
141Macrocytic anemia (HP:0001972)1.98476439
142Increased cerebral lipofuscin (HP:0011813)1.97574227
143Pulmonary fibrosis (HP:0002206)1.96712179
144Viral hepatitis (HP:0006562)1.96628791
145Metaphyseal cupping (HP:0003021)1.96202065
14611 pairs of ribs (HP:0000878)1.94044524
147Medial flaring of the eyebrow (HP:0010747)1.94020501
148Abnormal mitochondria in muscle tissue (HP:0008316)1.93254980
149Meningitis (HP:0001287)1.92730712
150Absent septum pellucidum (HP:0001331)1.92546987
151Obstructive lung disease (HP:0006536)1.92020441
152Chronic obstructive pulmonary disease (HP:0006510)1.92020441
153Toxemia of pregnancy (HP:0100603)1.91729196
154Abnormality of chromosome stability (HP:0003220)1.91584445
155Septo-optic dysplasia (HP:0100842)1.91066389
156Abnormal hair whorl (HP:0010721)1.91043344
157IgM deficiency (HP:0002850)1.90718692
158Acute hepatic failure (HP:0006554)1.90570836
159Abnormality of renal resorption (HP:0011038)1.90568103
160Azoospermia (HP:0000027)1.89773257
161Keratitis (HP:0000491)1.88069110
162Chronic otitis media (HP:0000389)1.87279454
163Premature loss of primary teeth (HP:0006323)1.87245656
164Abnormality of the phalanges of the hallux (HP:0010057)1.87084244
165Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87060189
166Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87060189
167Abnormality of dental color (HP:0011073)1.85953834
168Eosinophilia (HP:0001880)1.85519715
169Abnormality of magnesium homeostasis (HP:0004921)1.84943247
170Triphalangeal thumb (HP:0001199)1.82886733
171Abnormality of the pericardium (HP:0001697)1.82537870
172Pancytopenia (HP:0001876)1.82326378
173Agammaglobulinemia (HP:0004432)1.82025585
174Thrombophlebitis (HP:0004418)1.81972924
175Recurrent pneumonia (HP:0006532)1.80081942
176Subacute progressive viral hepatitis (HP:0006572)1.79257351
177Skin rash (HP:0000988)1.79181189
178Hypermelanotic macule (HP:0001034)1.78894213
179Verrucae (HP:0200043)1.78465497
180Papilloma (HP:0012740)1.78465497
181Recurrent sinusitis (HP:0011108)1.76560425
182Stomatitis (HP:0010280)1.76401188
183Short tibia (HP:0005736)1.75021964
184Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73745583
185Progressive macrocephaly (HP:0004481)1.71693000
186Panhypogammaglobulinemia (HP:0003139)1.70064843
187Split foot (HP:0001839)1.69800003
188Pendular nystagmus (HP:0012043)1.69378923
189Abnormality of the prostate (HP:0008775)1.69146020
190Abnormality of the columella (HP:0009929)1.67939028
191Renal tubular dysfunction (HP:0000124)1.66523545
192Poor suck (HP:0002033)1.66420937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.90354252
2RIPK44.85926965
3STK164.05605583
4TNIK3.53531611
5MAP2K33.39668588
6MKNK23.14328412
7EIF2AK33.02645102
8ERN12.81200978
9CSK2.61647107
10TYK22.58135359
11GRK62.57587643
12MUSK2.49286509
13MAP2K72.31954097
14MKNK12.23339027
15NME22.19863487
16PRPF4B2.15107341
17TLK12.14579329
18NLK2.13660680
19EPHB12.07881738
20IRAK42.06482492
21TAOK11.94357124
22SRPK11.93119172
23YES11.87558381
24MAP3K31.86141062
25FES1.84552217
26MAP3K111.83774515
27IRAK31.80207561
28HCK1.74996486
29EIF2AK21.67560453
30EIF2AK11.66560547
31JAK31.63018950
32TXK1.60300246
33FGR1.58197526
34TRIB31.55122175
35PIM21.54621683
36BUB11.54614778
37MAP3K121.53140220
38KSR21.50586842
39MAP3K131.49778618
40JAK21.42173865
41VRK11.41292920
42CLK11.40047888
43MAP3K11.40039917
44TEC1.39824220
45MAPK131.34438153
46WEE11.31231783
47TBK11.26429645
48CCNB11.26180788
49SIK31.22637039
50MARK21.20726893
51AKT31.20513814
52CDK191.19171723
53SGK21.11106459
54PTK61.10008689
55TAOK31.09325883
56CSF1R1.08664616
57IRAK21.07800180
58SMG11.06536123
59JAK11.06520113
60CAMKK21.01488902
61SIK21.01322395
62BLK1.01017033
63BMPR21.00172170
64IRAK11.00156803
65MARK31.00021611
66DYRK30.99125765
67CDK80.98461069
68CDK30.97512387
69ITK0.96049457
70PDK10.93553867
71DYRK20.92683022
72MAP2K40.91810511
73IKBKE0.88829130
74TAOK20.87603480
75ADRBK20.86489997
76PDPK10.84679037
77NME10.83710079
78MAP3K70.82392592
79KIT0.80477181
80ZAP700.79006292
81STK100.78937031
82BMPR1B0.78609410
83MATK0.77643618
84LRRK20.77467597
85MAP4K10.76819898
86SIK10.74806336
87PLK40.73032717
88MAPK120.72880446
89MAP2K60.72357092
90DYRK1A0.70779539
91MAP3K20.69364141
92SGK4940.68959662
93SGK2230.68959662
94STK110.67775674
95BTK0.67098782
96FYN0.65557422
97IKBKB0.65136287
98PIM10.64657796
99SYK0.63518504
100CAMK10.63098069
101HIPK20.62912382
102TESK10.62071672
103SGK30.58760433
104DAPK10.58708287
105STK380.58120404
106TSSK60.57832659
107ZAK0.57490635
108MAPK40.56830357
109RET0.56339633
110LYN0.55778015
111PIK3CG0.55344027
112RAF10.55151940
113PTK2B0.54993481
114CSNK1G10.54967263
115MAPK70.53774653
116MAP3K50.53630479
117TGFBR20.50245329
118FGFR40.50077419
119PRKCQ0.49654670
120PINK10.49596219
121PRKD20.49130788
122CAMKK10.48453162
123UHMK10.48317326
124FGFR30.48261304
125KSR10.48047128
126MAPKAPK50.47623309
127GRK70.47435998
128BRAF0.47386500
129MST40.46409369
130PKN20.46042630
131TESK20.45764040
132BRSK20.45477620
133TNK20.44546717
134MARK10.41259131
135MAP3K60.40677972
136CDK120.40444563
137CSNK2A10.40179714
138CAMK2B0.37935482
139AURKA0.37552839
140MAPKAPK20.37455245
141CDC42BPA0.36752583
142PLK10.36731659
143RPS6KL10.36057032
144RPS6KC10.36057032
145PRKCZ0.34771866
146RPS6KA60.33472146
147CDK70.33329209
148LCK0.33132744
149MAP2K20.33071254
150GRK10.32659345
151RPS6KA20.31976601
152PRKG20.31531044
153NUAK10.31155762
154DYRK1B0.30600484
155RPS6KA50.29922379
156CSNK1G30.29409963
157MYLK0.27988653
158NTRK20.27637869
159ADRBK10.26860923
160CSNK2A20.25550467
161GRK50.24269852
162ATR0.24026220
163MAP3K140.23528574
164CAMK2A0.23304299

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.05087361
2DNA replication_Homo sapiens_hsa030303.56548495
3Osteoclast differentiation_Homo sapiens_hsa043803.14730066
4RNA polymerase_Homo sapiens_hsa030203.13136535
5Leishmaniasis_Homo sapiens_hsa051403.02869840
6Homologous recombination_Homo sapiens_hsa034402.70766964
7Fanconi anemia pathway_Homo sapiens_hsa034602.70525296
8Staphylococcus aureus infection_Homo sapiens_hsa051502.70363833
9Basal transcription factors_Homo sapiens_hsa030222.62712117
10Proteasome_Homo sapiens_hsa030502.61905390
11B cell receptor signaling pathway_Homo sapiens_hsa046622.44565023
12Pyrimidine metabolism_Homo sapiens_hsa002402.43215109
13Base excision repair_Homo sapiens_hsa034102.36345774
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.31690484
15Mismatch repair_Homo sapiens_hsa034302.29390100
16Oxidative phosphorylation_Homo sapiens_hsa001902.19333017
17Spliceosome_Homo sapiens_hsa030402.15707275
18Tuberculosis_Homo sapiens_hsa051522.13311584
19Acute myeloid leukemia_Homo sapiens_hsa052212.03901976
20Protein export_Homo sapiens_hsa030602.03583975
21Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00470534
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99048853
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95831068
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.91918484
25Nucleotide excision repair_Homo sapiens_hsa034201.83977050
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78458431
27Chemokine signaling pathway_Homo sapiens_hsa040621.77623109
28Non-homologous end-joining_Homo sapiens_hsa034501.76735806
29Parkinsons disease_Homo sapiens_hsa050121.74848900
30Purine metabolism_Homo sapiens_hsa002301.74617181
31T cell receptor signaling pathway_Homo sapiens_hsa046601.72127138
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70819718
33Primary immunodeficiency_Homo sapiens_hsa053401.68481399
34Phototransduction_Homo sapiens_hsa047441.66869608
35Huntingtons disease_Homo sapiens_hsa050161.64303402
36Non-small cell lung cancer_Homo sapiens_hsa052231.50110668
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49020992
38Toxoplasmosis_Homo sapiens_hsa051451.45931140
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44818665
40Legionellosis_Homo sapiens_hsa051341.41198875
41Type I diabetes mellitus_Homo sapiens_hsa049401.39721562
42Phagosome_Homo sapiens_hsa041451.35278687
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34038138
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.33755966
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33103420
46Viral myocarditis_Homo sapiens_hsa054161.32961358
47Arachidonic acid metabolism_Homo sapiens_hsa005901.30752739
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28573460
49African trypanosomiasis_Homo sapiens_hsa051431.27612161
50Alzheimers disease_Homo sapiens_hsa050101.26349282
51Platelet activation_Homo sapiens_hsa046111.24702154
52RNA degradation_Homo sapiens_hsa030181.21009594
53Hepatitis B_Homo sapiens_hsa051611.20726291
54Nicotine addiction_Homo sapiens_hsa050331.20359419
55Chronic myeloid leukemia_Homo sapiens_hsa052201.19201425
56TNF signaling pathway_Homo sapiens_hsa046681.18912211
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17267960
58N-Glycan biosynthesis_Homo sapiens_hsa005101.16767626
59Pancreatic cancer_Homo sapiens_hsa052121.15497767
60VEGF signaling pathway_Homo sapiens_hsa043701.12416896
61Hepatitis C_Homo sapiens_hsa051601.11085731
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08465138
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08462259
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02972011
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.02911837
66RNA transport_Homo sapiens_hsa030131.01056077
67Renal cell carcinoma_Homo sapiens_hsa052111.00808320
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98697945
69Regulation of autophagy_Homo sapiens_hsa041400.96069591
70Prolactin signaling pathway_Homo sapiens_hsa049170.95451559
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.93687097
72Shigellosis_Homo sapiens_hsa051310.93499877
73Cell cycle_Homo sapiens_hsa041100.93279062
74Apoptosis_Homo sapiens_hsa042100.92042847
75Pertussis_Homo sapiens_hsa051330.91105525
76Measles_Homo sapiens_hsa051620.88356879
77Endocytosis_Homo sapiens_hsa041440.87895418
78Notch signaling pathway_Homo sapiens_hsa043300.87370967
79Sulfur relay system_Homo sapiens_hsa041220.86484362
80Herpes simplex infection_Homo sapiens_hsa051680.85294403
81Hematopoietic cell lineage_Homo sapiens_hsa046400.84762444
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84159486
83Endometrial cancer_Homo sapiens_hsa052130.84125785
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83955162
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82826393
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82328970
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.82182820
88Graft-versus-host disease_Homo sapiens_hsa053320.81240251
89Other glycan degradation_Homo sapiens_hsa005110.80690949
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.79371484
91Vitamin B6 metabolism_Homo sapiens_hsa007500.78969352
92FoxO signaling pathway_Homo sapiens_hsa040680.78561908
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78161727
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.77490727
95Sphingolipid metabolism_Homo sapiens_hsa006000.77041786
96Choline metabolism in cancer_Homo sapiens_hsa052310.75538242
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72556302
98Allograft rejection_Homo sapiens_hsa053300.71735798
99Asthma_Homo sapiens_hsa053100.71340767
100Dorso-ventral axis formation_Homo sapiens_hsa043200.71271750
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.70378234
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70332590
103Viral carcinogenesis_Homo sapiens_hsa052030.70129601
104Inositol phosphate metabolism_Homo sapiens_hsa005620.68792176
105One carbon pool by folate_Homo sapiens_hsa006700.68352565
106Colorectal cancer_Homo sapiens_hsa052100.68319698
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.67501256
108Autoimmune thyroid disease_Homo sapiens_hsa053200.67211941
109GnRH signaling pathway_Homo sapiens_hsa049120.66098261
110mTOR signaling pathway_Homo sapiens_hsa041500.65883003
111Taste transduction_Homo sapiens_hsa047420.65658718
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65458057
113Systemic lupus erythematosus_Homo sapiens_hsa053220.64673847
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64158880
115Linoleic acid metabolism_Homo sapiens_hsa005910.63815729
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63760910
117p53 signaling pathway_Homo sapiens_hsa041150.63360237
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62978293
119Epstein-Barr virus infection_Homo sapiens_hsa051690.62272361
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.61125631
121Lysosome_Homo sapiens_hsa041420.59506985
122mRNA surveillance pathway_Homo sapiens_hsa030150.59029902
123Amoebiasis_Homo sapiens_hsa051460.58436217
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58184745
125Insulin resistance_Homo sapiens_hsa049310.57507858
126MAPK signaling pathway_Homo sapiens_hsa040100.57471912
127Collecting duct acid secretion_Homo sapiens_hsa049660.57287662
128Ether lipid metabolism_Homo sapiens_hsa005650.57143414
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56178198
130Metabolic pathways_Homo sapiens_hsa011000.55766670
131Serotonergic synapse_Homo sapiens_hsa047260.54589680
132HTLV-I infection_Homo sapiens_hsa051660.54444693
133Type II diabetes mellitus_Homo sapiens_hsa049300.54404875
134ErbB signaling pathway_Homo sapiens_hsa040120.53832656
135Morphine addiction_Homo sapiens_hsa050320.53019225
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52587197
137HIF-1 signaling pathway_Homo sapiens_hsa040660.51547924
138Rap1 signaling pathway_Homo sapiens_hsa040150.49778018
139Alcoholism_Homo sapiens_hsa050340.48603720
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46522425
141Estrogen signaling pathway_Homo sapiens_hsa049150.46246355
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46029285
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.45748565
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44559026
145Rheumatoid arthritis_Homo sapiens_hsa053230.43864311
146Prostate cancer_Homo sapiens_hsa052150.43675973
147Insulin signaling pathway_Homo sapiens_hsa049100.43177227
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42381562
149Synaptic vesicle cycle_Homo sapiens_hsa047210.41924795
150Malaria_Homo sapiens_hsa051440.40937718
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39307117
152Thyroid cancer_Homo sapiens_hsa052160.38472643
153Fatty acid elongation_Homo sapiens_hsa000620.36547085
154Olfactory transduction_Homo sapiens_hsa047400.35174479
155Salmonella infection_Homo sapiens_hsa051320.35035840
156Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34254516
157Glutathione metabolism_Homo sapiens_hsa004800.32689296
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.31283260
159Pentose phosphate pathway_Homo sapiens_hsa000300.31238546
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30945011
161Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30453843
162Antigen processing and presentation_Homo sapiens_hsa046120.28905169
163Cardiac muscle contraction_Homo sapiens_hsa042600.27398545
164NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26580820
165Influenza A_Homo sapiens_hsa051640.26047280
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22674615
167Circadian rhythm_Homo sapiens_hsa047100.22190254
168Drug metabolism - other enzymes_Homo sapiens_hsa009830.21738480
169Folate biosynthesis_Homo sapiens_hsa007900.19775347

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