FRAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.69247533
2modulation by symbiont of host defense response (GO:0052031)6.69247533
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.69247533
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.69247533
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.69247533
6modulation by symbiont of host immune response (GO:0052553)6.69247533
7negative regulation of cell killing (GO:0031342)6.63699478
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.63699478
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.53544616
10detection of other organism (GO:0098543)5.49651009
11neutrophil activation involved in immune response (GO:0002283)5.49014896
12antigen processing and presentation of endogenous antigen (GO:0019883)5.29326739
13detection of bacterium (GO:0016045)5.17063313
14macrophage activation involved in immune response (GO:0002281)5.12599196
15ribosomal small subunit assembly (GO:0000028)5.03718435
16respiratory burst (GO:0045730)4.95103858
17detection of molecule of bacterial origin (GO:0032490)4.93712690
18leukocyte migration involved in inflammatory response (GO:0002523)4.88840694
19response to peptidoglycan (GO:0032494)4.85631330
20detection of external biotic stimulus (GO:0098581)4.83795040
21leukocyte aggregation (GO:0070486)4.78136564
22regulation of B cell receptor signaling pathway (GO:0050855)4.75777497
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.58218345
24cellular extravasation (GO:0045123)4.52822834
25response to host immune response (GO:0052572)4.47198075
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.47198075
27regulation of interferon-beta biosynthetic process (GO:0045357)4.45396726
28negative regulation of interleukin-12 production (GO:0032695)4.40812113
29neutrophil activation (GO:0042119)4.39028409
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.35591507
31detection of biotic stimulus (GO:0009595)4.24642165
32viral transcription (GO:0019083)4.21596997
33response to interleukin-15 (GO:0070672)4.17831775
34DNA deamination (GO:0045006)4.16778403
35doxorubicin metabolic process (GO:0044598)4.15314394
36daunorubicin metabolic process (GO:0044597)4.15314394
37polyketide metabolic process (GO:0030638)4.15314394
38microglial cell activation (GO:0001774)4.13290732
39response to host (GO:0075136)4.05765791
40response to host defenses (GO:0052200)4.05765791
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.05765791
42translational termination (GO:0006415)4.04804326
43neutrophil mediated immunity (GO:0002446)4.00445613
44positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.95232828
45granulocyte activation (GO:0036230)3.94595919
46negative regulation of leukocyte mediated immunity (GO:0002704)3.84563620
47macrophage activation (GO:0042116)3.82370578
48production of molecular mediator involved in inflammatory response (GO:0002532)3.81578896
49cellular response to interleukin-15 (GO:0071350)3.81376146
50telomere maintenance via semi-conservative replication (GO:0032201)3.80251303
51immunoglobulin mediated immune response (GO:0016064)3.75401692
52DNA strand elongation involved in DNA replication (GO:0006271)3.74065957
53regulation of mast cell degranulation (GO:0043304)3.72908880
54myeloid cell activation involved in immune response (GO:0002275)3.71102072
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.67360482
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.65408894
57DNA strand elongation (GO:0022616)3.62527192
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.57718017
59antigen processing and presentation via MHC class Ib (GO:0002475)3.57499716
60translational elongation (GO:0006414)3.52627835
61negative regulation of T cell mediated immunity (GO:0002710)3.51712013
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50010746
63regulation of leukocyte degranulation (GO:0043300)3.48944030
64ribosomal small subunit biogenesis (GO:0042274)3.47936052
65interferon-gamma production (GO:0032609)3.45470685
66myeloid leukocyte mediated immunity (GO:0002444)3.40855979
67telomere maintenance via recombination (GO:0000722)3.40045760
68mitotic sister chromatid cohesion (GO:0007064)3.37549442
69regulation of mast cell activation involved in immune response (GO:0033006)3.36195780
70V(D)J recombination (GO:0033151)3.35391728
71maturation of SSU-rRNA (GO:0030490)3.35188440
72B cell receptor signaling pathway (GO:0050853)3.34552647
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32801432
74negative regulation of phagocytosis (GO:0050765)3.29871305
75positive regulation of mast cell activation (GO:0033005)3.29339575
76DNA replication initiation (GO:0006270)3.28103057
77type I interferon signaling pathway (GO:0060337)3.27583564
78cellular response to type I interferon (GO:0071357)3.27583564
79translesion synthesis (GO:0019985)3.25456756
80positive regulation of gamma-delta T cell activation (GO:0046645)3.25142906
81response to type I interferon (GO:0034340)3.24639799
82leukocyte degranulation (GO:0043299)3.23562421
83cotranslational protein targeting to membrane (GO:0006613)3.21818607
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21576438
85regulation of regulated secretory pathway (GO:1903305)3.21544501
86protein targeting to ER (GO:0045047)3.21262431
87DNA unwinding involved in DNA replication (GO:0006268)3.17706858
88cellular protein complex disassembly (GO:0043624)3.16777821
89regulation of histone H3-K9 methylation (GO:0051570)3.15292198
90regulation of B cell differentiation (GO:0045577)3.14843612
91mitotic recombination (GO:0006312)3.14337883
92protein localization to chromosome, centromeric region (GO:0071459)3.13928499
93regulation of gamma-delta T cell differentiation (GO:0045586)3.13809578
94viral life cycle (GO:0019058)3.12321656
95B cell mediated immunity (GO:0019724)3.10750574
96translational initiation (GO:0006413)3.10071784
97dendritic cell chemotaxis (GO:0002407)3.09543739
98regulation of T-helper 2 cell differentiation (GO:0045628)3.08627891
993-UTR-mediated mRNA stabilization (GO:0070935)3.08325233
100dendritic cell migration (GO:0036336)3.07535294
101negative regulation of RNA splicing (GO:0033119)3.07013345
102regulation of T cell tolerance induction (GO:0002664)3.05004084
103regulation of mast cell activation (GO:0033003)3.04916268
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04580740
105establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04466005
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04307113
107regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03136309
108positive regulation of Cdc42 GTPase activity (GO:0043089)3.02331459
109regulation of tolerance induction (GO:0002643)3.00526075
110protein localization to endoplasmic reticulum (GO:0070972)2.99407671
111T cell homeostasis (GO:0043029)2.97603100
112negative regulation of innate immune response (GO:0045824)2.97450452
113response to muramyl dipeptide (GO:0032495)2.97273192
114regulation of gamma-delta T cell activation (GO:0046643)2.96686976
115protein complex disassembly (GO:0043241)2.95553123
116defense response to protozoan (GO:0042832)2.95043248
117telomere maintenance via telomere lengthening (GO:0010833)2.94066452
118negative regulation of toll-like receptor signaling pathway (GO:0034122)2.92252351
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92120078
120ribosomal large subunit biogenesis (GO:0042273)2.90322014
121positive regulation of interferon-alpha production (GO:0032727)2.89984981
122nuclear-transcribed mRNA catabolic process (GO:0000956)2.88807054
123negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88464181
124negative regulation of T-helper cell differentiation (GO:0045623)2.88464181
125protein localization to kinetochore (GO:0034501)2.88353832
126dosage compensation (GO:0007549)2.87040395
127negative regulation of interleukin-6 production (GO:0032715)2.85375214
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85163881
129definitive hemopoiesis (GO:0060216)2.84517025
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84256197
131positive regulation of regulated secretory pathway (GO:1903307)2.83819650
132negative regulation of type 2 immune response (GO:0002829)2.82799478
133myeloid leukocyte activation (GO:0002274)2.81930239
134motile cilium assembly (GO:0044458)2.81919973
135chromatin remodeling at centromere (GO:0031055)2.80806642
136interferon-gamma secretion (GO:0072643)2.80456763
137regulation of T cell mediated cytotoxicity (GO:0001914)2.80037254
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.79266387
139germinal center formation (GO:0002467)2.78288604
140mRNA catabolic process (GO:0006402)2.78058558
141neutrophil chemotaxis (GO:0030593)2.77163100
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76196708
143intra-S DNA damage checkpoint (GO:0031573)2.76190881
144CENP-A containing nucleosome assembly (GO:0034080)2.74531438
145regulation of erythrocyte differentiation (GO:0045646)2.74295274
146RNA catabolic process (GO:0006401)2.73387247
147nucleotide-excision repair, DNA gap filling (GO:0006297)2.73243827
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71653778
149macromolecular complex disassembly (GO:0032984)2.71428636
150Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71250903
151negative regulation of erythrocyte differentiation (GO:0045647)2.70573173
152embryonic hemopoiesis (GO:0035162)2.70567945
153positive regulation of granulocyte differentiation (GO:0030854)2.70519299
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70133861
155antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70133861
156DNA replication checkpoint (GO:0000076)2.67478116
157centriole assembly (GO:0098534)2.65504692
158DNA replication-independent nucleosome organization (GO:0034724)2.64818221
159DNA replication-independent nucleosome assembly (GO:0006336)2.64818221
160DNA topological change (GO:0006265)2.63857590
161ribonucleoprotein complex biogenesis (GO:0022613)2.63237696
162positive regulation of B cell differentiation (GO:0045579)2.63206828
163regulation of DNA endoreduplication (GO:0032875)2.63164054
164granulocyte differentiation (GO:0030851)2.62359049
165kinetochore organization (GO:0051383)2.62349691
166erythrocyte maturation (GO:0043249)2.61460955
167telomere organization (GO:0032200)2.60344614
168somatic cell DNA recombination (GO:0016444)2.60059182
169somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60059182
170telomere maintenance (GO:0000723)2.59863076
171positive T cell selection (GO:0043368)2.57122238
172DNA synthesis involved in DNA repair (GO:0000731)2.56011951
173maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55949682
174histone H2A acetylation (GO:0043968)2.55712993
175termination of RNA polymerase II transcription (GO:0006369)2.55697703
176negative regulation of mRNA processing (GO:0050686)2.54355762
177positive thymic T cell selection (GO:0045059)2.53906743
178tRNA methylation (GO:0030488)2.49923726
179megakaryocyte development (GO:0035855)2.49755010
180somatic diversification of immune receptors (GO:0002200)2.48887613
181lymphoid progenitor cell differentiation (GO:0002320)2.47949139
182regulation of nuclear cell cycle DNA replication (GO:0033262)2.47789721
183histone exchange (GO:0043486)2.43432808
184lymphocyte homeostasis (GO:0002260)2.42888876
185histone mRNA metabolic process (GO:0008334)2.42179112
186kinetochore assembly (GO:0051382)2.40680726
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.38193547
188protein localization to chromosome (GO:0034502)2.37140619
189pseudouridine synthesis (GO:0001522)2.36955382
190positive regulation of erythrocyte differentiation (GO:0045648)2.36845412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53516712
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.88251818
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62028132
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.35389068
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01208372
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00836656
7SCL_19346495_ChIP-Seq_HPC-7_Human2.96300213
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.94887201
9MYC_22102868_ChIP-Seq_BL_Human2.91609009
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.83059000
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57957344
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.56962244
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56126895
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.53299728
15* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.46675382
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35437995
17VDR_21846776_ChIP-Seq_THP-1_Human2.33868339
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33057945
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27978131
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23538724
21* NOTCH1_21737748_ChIP-Seq_TLL_Human2.22516079
22SPI1_23127762_ChIP-Seq_K562_Human2.20884449
23VDR_23849224_ChIP-Seq_CD4+_Human2.13357562
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13172376
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07931282
26CIITA_25753668_ChIP-Seq_RAJI_Human2.02854718
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01377342
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99340869
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96728237
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95256137
31FOXP3_21729870_ChIP-Seq_TREG_Human1.95200171
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.93753477
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93380722
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92617624
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92054957
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91627337
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90867560
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.88086797
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86515327
40XRN2_22483619_ChIP-Seq_HELA_Human1.85957945
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85767889
42KDM2B_26808549_Chip-Seq_DND41_Human1.84860861
43* MYB_26560356_Chip-Seq_TH2_Human1.84692937
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.84373918
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78552784
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77058306
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73194519
48* SPI1_23547873_ChIP-Seq_NB4_Human1.69647599
49TCF7_22412390_ChIP-Seq_EML_Mouse1.69567480
50MYB_26560356_Chip-Seq_TH1_Human1.69123885
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.67840531
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65869889
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.65265004
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.62564621
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62416973
56UTX_26944678_Chip-Seq_JUKART_Human1.61748612
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.60279607
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59565918
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59207323
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58478518
61MAF_26560356_Chip-Seq_TH1_Human1.57903722
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57718330
63* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55928918
64VDR_24763502_ChIP-Seq_THP-1_Human1.55610379
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54126519
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.52410357
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52052721
68* TTF2_22483619_ChIP-Seq_HELA_Human1.51628539
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51372601
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49082736
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45090941
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43058934
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41910274
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39888722
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39569069
76ELK1_19687146_ChIP-ChIP_HELA_Human1.39310164
77LXR_22292898_ChIP-Seq_THP-1_Human1.37531232
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36649131
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35668037
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.35410982
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34596952
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33032594
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32526693
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32286411
85GATA3_27048872_Chip-Seq_THYMUS_Human1.30503752
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30140814
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29371940
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28816959
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28816959
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28816959
91GABP_19822575_ChIP-Seq_HepG2_Human1.28623103
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28083524
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26026555
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25990222
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25385788
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25217179
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24992209
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.24831614
99DCP1A_22483619_ChIP-Seq_HELA_Human1.24642699
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22345308
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21866980
102MAF_26560356_Chip-Seq_TH2_Human1.21776369
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.21447463
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21424819
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21251584
106RUNX_20019798_ChIP-Seq_JUKART_Human1.21153717
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20421208
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.20291943
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19773742
110KDM5A_27292631_Chip-Seq_BREAST_Human1.19689858
111NCOR1_26117541_ChIP-Seq_K562_Human1.18740441
112BCOR_27268052_Chip-Seq_Bcells_Human1.18479282
113* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18298119
114PU_27001747_Chip-Seq_BMDM_Mouse1.16470061
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16057688
116* RACK7_27058665_Chip-Seq_MCF-7_Human1.14805959
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14601354
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11868765
119* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09565775
120BCL6_27268052_Chip-Seq_Bcells_Human1.07948078
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07249155
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07131101
123VDR_24787735_ChIP-Seq_THP-1_Human1.06554723
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05443792
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05205290
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04340791
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03999145
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03398181
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.00416005
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00317312
131MYC_18940864_ChIP-ChIP_HL60_Human1.00021531
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.99167587
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98417820
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97191132
135P68_20966046_ChIP-Seq_HELA_Human0.96434520
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96176041
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95842576
138TFEB_21752829_ChIP-Seq_HELA_Human0.95268113
139RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94427707
140* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94183209
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94012779
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93843140
143* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93772600
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93507570
145GATA3_26560356_Chip-Seq_TH2_Human0.93372965
146AR_21909140_ChIP-Seq_LNCAP_Human0.93313150
147E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92552618
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90671703
149* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89919614
150KDM2B_26808549_Chip-Seq_K562_Human0.87298049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.75276749
2MP0008057_abnormal_DNA_replication3.66696244
3MP0008260_abnormal_autophagy3.25679811
4MP0002132_abnormal_respiratory_system3.09103668
5MP0010094_abnormal_chromosome_stability3.04258786
6MP0003763_abnormal_thymus_physiology2.98378369
7MP0003693_abnormal_embryo_hatching2.91388397
8MP0003111_abnormal_nucleus_morphology2.83953789
9MP0005397_hematopoietic_system_phenotyp2.82097663
10MP0001545_abnormal_hematopoietic_system2.82097663
11MP0004808_abnormal_hematopoietic_stem2.60426267
12MP0003191_abnormal_cellular_cholesterol2.58511146
13MP0000490_abnormal_crypts_of2.57579764
14MP0008058_abnormal_DNA_repair2.44936565
15MP0003077_abnormal_cell_cycle2.44644414
16MP0005451_abnormal_body_composition2.30816905
17MP0002398_abnormal_bone_marrow2.19786135
18MP0004957_abnormal_blastocyst_morpholog2.08658958
19MP0006082_CNS_inflammation2.06458792
20MP0000703_abnormal_thymus_morphology2.05523670
21MP0001533_abnormal_skeleton_physiology1.98472798
22MP0000685_abnormal_immune_system1.94230747
23MP0005174_abnormal_tail_pigmentation1.92668028
24MP0008007_abnormal_cellular_replicative1.90663451
25MP0003300_gastrointestinal_ulcer1.90637793
26MP0005671_abnormal_response_to1.84089191
27MP0003828_pulmonary_edema1.83517074
28MP0009278_abnormal_bone_marrow1.81798289
29MP0002166_altered_tumor_susceptibility1.78877633
30MP0002722_abnormal_immune_system1.77110633
31MP0001835_abnormal_antigen_presentation1.76966962
32MP0001873_stomach_inflammation1.76754289
33MP0003183_abnormal_peptide_metabolism1.75533239
34MP0001800_abnormal_humoral_immune1.70245698
35MP0002420_abnormal_adaptive_immunity1.70123109
36MP0000716_abnormal_immune_system1.69694122
37MP0001819_abnormal_immune_cell1.67582192
38MP0004381_abnormal_hair_follicle1.63596125
39MP0000689_abnormal_spleen_morphology1.61861251
40MP0002006_tumorigenesis1.61544919
41MP0010155_abnormal_intestine_physiology1.60728331
42MP0003436_decreased_susceptibility_to1.60005659
43MP0002429_abnormal_blood_cell1.58901333
44MP0002723_abnormal_immune_serum1.56725937
45MP0002405_respiratory_system_inflammati1.56710528
46MP0006292_abnormal_olfactory_placode1.54029898
47MP0009333_abnormal_splenocyte_physiolog1.53408521
48MP0002452_abnormal_antigen_presenting1.52845496
49MP0005410_abnormal_fertilization1.51605835
50MP0003656_abnormal_erythrocyte_physiolo1.51277292
51MP0000465_gastrointestinal_hemorrhage1.49909160
52MP0003866_abnormal_defecation1.46724341
53MP0005000_abnormal_immune_tolerance1.46625030
54MP0005025_abnormal_response_to1.46239502
55MP0002009_preneoplasia1.44096541
56MP0001853_heart_inflammation1.42413844
57MP0005075_abnormal_melanosome_morpholog1.41224348
58MP0002095_abnormal_skin_pigmentation1.39846453
59MP0002019_abnormal_tumor_incidence1.38083065
60MP0008877_abnormal_DNA_methylation1.36206877
61MP0003724_increased_susceptibility_to1.32006811
62MP0003172_abnormal_lysosome_physiology1.31071577
63MP0002148_abnormal_hypersensitivity_rea1.30753199
64MP0009785_altered_susceptibility_to1.28570618
65MP0008469_abnormal_protein_level1.28411181
66MP0008995_early_reproductive_senescence1.26824963
67MP0005464_abnormal_platelet_physiology1.21549217
68MP0001790_abnormal_immune_system1.20311537
69MP0005387_immune_system_phenotype1.20311537
70MP0003786_premature_aging1.20243460
71MP0009764_decreased_sensitivity_to1.19264767
72MP0002419_abnormal_innate_immunity1.18499763
73MP0000313_abnormal_cell_death1.18328659
74MP0004883_abnormal_blood_vessel1.18270753
75MP0000350_abnormal_cell_proliferation1.17609106
76MP0001929_abnormal_gametogenesis1.17299812
77MP0000858_altered_metastatic_potential1.15826905
78MP0001851_eye_inflammation1.14141883
79MP0004147_increased_porphyrin_level1.11010818
80MP0010307_abnormal_tumor_latency1.10659771
81MP0002163_abnormal_gland_morphology1.08873259
82MP0000015_abnormal_ear_pigmentation1.08709642
83MP0001986_abnormal_taste_sensitivity1.08464417
84MP0010352_gastrointestinal_tract_polyps1.07869927
85MP0002998_abnormal_bone_remodeling1.06065499
86MP0002277_abnormal_respiratory_mucosa1.03830836
87MP0002210_abnormal_sex_determination1.03664455
88MP0003075_altered_response_to1.03049801
89MP0003221_abnormal_cardiomyocyte_apopto0.94891819
90MP0008789_abnormal_olfactory_epithelium0.92325284
91MP0001845_abnormal_inflammatory_respons0.91895583
92MP0003303_peritoneal_inflammation0.91077571
93MP0005409_darkened_coat_color0.90796432
94MP0003787_abnormal_imprinting0.90790485
95MP0003698_abnormal_male_reproductive0.90470713
96MP0005058_abnormal_lysosome_morphology0.89336547
97MP0001663_abnormal_digestive_system0.89294612
98MP0003878_abnormal_ear_physiology0.88956760
99MP0005377_hearing/vestibular/ear_phenot0.88956760
100MP0002254_reproductive_system_inflammat0.88885707
101MP0003806_abnormal_nucleotide_metabolis0.88568316
102MP0005083_abnormal_biliary_tract0.88349891
103MP0001145_abnormal_male_reproductive0.86301974
104MP0009379_abnormal_foot_pigmentation0.84912720
105MP0003690_abnormal_glial_cell0.83393752
106MP0003943_abnormal_hepatobiliary_system0.83212738
107MP0004264_abnormal_extraembryonic_tissu0.82484541
108MP0004858_abnormal_nervous_system0.82257380
109MP0003448_altered_tumor_morphology0.81028868
110MP0005310_abnormal_salivary_gland0.79551281
111MP0008004_abnormal_stomach_pH0.79453458
112MP0001188_hyperpigmentation0.79318073
113MP0005076_abnormal_cell_differentiation0.78348836
114MP0004947_skin_inflammation0.78147662
115MP0006054_spinal_hemorrhage0.77952189
116MP0000653_abnormal_sex_gland0.77807531
117MP0005164_abnormal_response_to0.76748041
118MP0004185_abnormal_adipocyte_glucose0.74357303
119MP0005166_decreased_susceptibility_to0.74334220
120MP0001730_embryonic_growth_arrest0.72691112
121MP0005390_skeleton_phenotype0.71695135
122MP0002102_abnormal_ear_morphology0.71052823
123MP0004510_myositis0.70735623
124MP0008932_abnormal_embryonic_tissue0.70243661
125MP0000477_abnormal_intestine_morphology0.67589169
126MP0009763_increased_sensitivity_to0.66319685
127MP0001849_ear_inflammation0.66212936
128MP0005319_abnormal_enzyme/_coenzyme0.65204873
129MP0005423_abnormal_somatic_nervous0.64662171
130MP0001293_anophthalmia0.62524469
131MP0000470_abnormal_stomach_morphology0.62242062
132MP0002080_prenatal_lethality0.60405479
133MP0009697_abnormal_copulation0.59900064
134MP0008874_decreased_physiological_sensi0.59599098
135MP0001119_abnormal_female_reproductive0.59285663
136MP0005394_taste/olfaction_phenotype0.59242815
137MP0003705_abnormal_hypodermis_morpholog0.56803785
138MP0002796_impaired_skin_barrier0.56335702
139MP0009765_abnormal_xenobiotic_induced0.55502310
140MP0006035_abnormal_mitochondrial_morpho0.52446852
141MP0003795_abnormal_bone_structure0.51515163

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)5.53027364
2Recurrent gram-negative bacterial infections (HP:0005420)5.32754672
3Abnormal number of erythroid precursors (HP:0012131)5.12990980
4Abnormality of cells of the erythroid lineage (HP:0012130)4.96863465
5Stomatitis (HP:0010280)4.96294847
6Hypochromic microcytic anemia (HP:0004840)4.92486403
7Gastrointestinal infarctions (HP:0005244)4.51006556
8Chronic otitis media (HP:0000389)4.35790459
9Hypochromic anemia (HP:0001931)4.16161425
10Recurrent skin infections (HP:0001581)4.06421430
11Reticulocytopenia (HP:0001896)3.89415256
12Gingivitis (HP:0000230)3.85736779
13Urticaria (HP:0001025)3.75662387
14Keratoconjunctivitis sicca (HP:0001097)3.74966582
15Spontaneous hematomas (HP:0007420)3.52801903
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.49905712
17Panhypogammaglobulinemia (HP:0003139)3.46102079
18Keratoconjunctivitis (HP:0001096)3.45177909
19Increased IgE level (HP:0003212)3.42469475
20Petechiae (HP:0000967)3.31626681
21Chromsome breakage (HP:0040012)3.26956014
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.22837516
23Thrombocytosis (HP:0001894)3.16482707
24Vasculitis (HP:0002633)3.15621249
25Abnormality of B cell number (HP:0010975)3.14964866
26B lymphocytopenia (HP:0010976)3.14964866
27Chest pain (HP:0100749)3.12482457
28Anorexia (HP:0002039)3.10240173
29Pallor (HP:0000980)3.05366043
30Absent/shortened dynein arms (HP:0200106)2.97526525
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.97526525
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97366644
33Episodic fever (HP:0001954)2.93448394
34Prolonged bleeding time (HP:0003010)2.93276407
35Nasal polyposis (HP:0100582)2.91273326
36Myositis (HP:0100614)2.90306445
37Arterial thrombosis (HP:0004420)2.88804333
38Abnormality of the fingertips (HP:0001211)2.88024687
39Microcytic anemia (HP:0001935)2.86329252
40Recurrent fungal infections (HP:0002841)2.86231612
41IgM deficiency (HP:0002850)2.84729059
42Aplastic anemia (HP:0001915)2.83315975
43Recurrent viral infections (HP:0004429)2.80868093
44Elevated erythrocyte sedimentation rate (HP:0003565)2.76534477
45Acute lymphatic leukemia (HP:0006721)2.74305581
46Hemoptysis (HP:0002105)2.73877057
47Peritonitis (HP:0002586)2.71121416
48Abnormality of the prostate (HP:0008775)2.70541352
49Myelodysplasia (HP:0002863)2.69181279
50Osteomyelitis (HP:0002754)2.69018841
51Gastrointestinal inflammation (HP:0004386)2.66216368
52Inflammation of the large intestine (HP:0002037)2.63587475
53Gingival bleeding (HP:0000225)2.63270793
54Birth length less than 3rd percentile (HP:0003561)2.61659648
55Abnormality of the preputium (HP:0100587)2.61039970
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.59142873
57Volvulus (HP:0002580)2.56875923
58Metaphyseal cupping (HP:0003021)2.55479486
59Pulmonary embolism (HP:0002204)2.54584518
60Increased IgM level (HP:0003496)2.53210474
61Acute myeloid leukemia (HP:0004808)2.49139442
62Abnormality of chromosome stability (HP:0003220)2.46941296
63Abnormality of DNA repair (HP:0003254)2.46442067
64Hypoplasia of the thymus (HP:0000778)2.41269300
65T lymphocytopenia (HP:0005403)2.40616922
66Amyloidosis (HP:0011034)2.39674747
67Pulmonary infiltrates (HP:0002113)2.38735367
68Cheilitis (HP:0100825)2.36218288
69Optic neuritis (HP:0100653)2.35936467
70Retrobulbar optic neuritis (HP:0100654)2.35936467
71Severe combined immunodeficiency (HP:0004430)2.35737437
72Sepsis (HP:0100806)2.34932591
73Abnormal respiratory epithelium morphology (HP:0012253)2.34667478
74Abnormal respiratory motile cilium morphology (HP:0005938)2.34667478
75Meningitis (HP:0001287)2.34274548
76Poikiloderma (HP:0001029)2.34112627
77Reduced antithrombin III activity (HP:0001976)2.33440638
78Type I transferrin isoform profile (HP:0003642)2.32726587
79Thyroiditis (HP:0100646)2.32504071
80Slow saccadic eye movements (HP:0000514)2.31650173
81Abnormality of T cells (HP:0002843)2.30902060
82Chronic mucocutaneous candidiasis (HP:0002728)2.30263745
83Recurrent cutaneous fungal infections (HP:0011370)2.30263745
84Macrocytic anemia (HP:0001972)2.29716679
85Premature loss of primary teeth (HP:0006323)2.29385961
86Prominent nose (HP:0000448)2.28120383
87Abnormality of T cell number (HP:0011839)2.27345771
88Granulocytopenia (HP:0001913)2.26841478
89Eosinophilia (HP:0001880)2.25866603
90Lymphoma (HP:0002665)2.23635411
91Abnormality of the columella (HP:0009929)2.22700548
92Prostate neoplasm (HP:0100787)2.21908437
93IgG deficiency (HP:0004315)2.19573198
94Abnormality of the nasal mucosa (HP:0000433)2.19439017
95Subacute progressive viral hepatitis (HP:0006572)2.19317431
96Clubbing of toes (HP:0100760)2.17029832
97Acanthocytosis (HP:0001927)2.16211333
98Chronic sinusitis (HP:0011109)2.14948267
99Abnormality of the peritoneum (HP:0002585)2.13436534
100Recurrent bronchitis (HP:0002837)2.12196664
101Increased serum ferritin (HP:0003281)2.12115340
102Gangrene (HP:0100758)2.11452769
103Ectopic kidney (HP:0000086)2.10836711
104Pustule (HP:0200039)2.09491622
105Absent thumb (HP:0009777)2.09095876
106Skin ulcer (HP:0200042)2.08421210
107Abnormality of the ileum (HP:0001549)2.06581051
108Recurrent abscess formation (HP:0002722)2.06096235
109Poikilocytosis (HP:0004447)2.05047618
110Segmental peripheral demyelination/remyelination (HP:0003481)2.04409237
111Meckel diverticulum (HP:0002245)2.04235024
112Abnormality of T cell physiology (HP:0011840)2.03894762
113Viral hepatitis (HP:0006562)2.03468342
114Abnormality of eosinophils (HP:0001879)2.03290538
115Chronic obstructive pulmonary disease (HP:0006510)2.03211837
116Obstructive lung disease (HP:0006536)2.03211837
117Abnormal number of incisors (HP:0011064)2.03150436
118Colitis (HP:0002583)2.02784160
119Abnormality of the pleura (HP:0002103)2.02732035
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.02223054
121Optic nerve coloboma (HP:0000588)2.01300705
122Abnormality of the endocardium (HP:0004306)2.01181474
123Hepatosplenomegaly (HP:0001433)2.01162093
124Combined immunodeficiency (HP:0005387)1.99836477
125Eczematoid dermatitis (HP:0000976)1.98383899
126Abnormality of iron homeostasis (HP:0011031)1.98258584
127Bone marrow hypocellularity (HP:0005528)1.97408459
128Orchitis (HP:0100796)1.97286738
129Acute hepatic failure (HP:0006554)1.97067461
130Glomerulopathy (HP:0100820)1.93303053
131Recurrent bacterial skin infections (HP:0005406)1.93119642
132Muscle fiber atrophy (HP:0100295)1.91934475
133Hypermelanotic macule (HP:0001034)1.91287487
134Encephalitis (HP:0002383)1.89666704
135Abnormality of reticulocytes (HP:0004312)1.89502866
136Toxemia of pregnancy (HP:0100603)1.88166550
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87762967
138Acne (HP:0001061)1.87626083
139Bronchiectasis (HP:0002110)1.87581651
140Epistaxis (HP:0000421)1.86240250
141Oral leukoplakia (HP:0002745)1.85476734
142Abnormality of cells of the lymphoid lineage (HP:0012140)1.84566883
143Abnormal platelet function (HP:0011869)1.83979322
144Impaired platelet aggregation (HP:0003540)1.83979322
145Leukocytosis (HP:0001974)1.83508597
146Hypergammaglobulinemia (HP:0010702)1.82341583
147Mediastinal lymphadenopathy (HP:0100721)1.82310361
148Amaurosis fugax (HP:0100576)1.81917480
149Abnormality of the pericardium (HP:0001697)1.81780245
150Cellulitis (HP:0100658)1.81276592
151Keratitis (HP:0000491)1.81152591
152Abnormal platelet volume (HP:0011876)1.80984983
153Exertional dyspnea (HP:0002875)1.80270898
154Recurrent pneumonia (HP:0006532)1.80015456
155Polycythemia (HP:0001901)1.79709427
156Lymphopenia (HP:0001888)1.79521359
157Purpura (HP:0000979)1.78712881
158Pancytopenia (HP:0001876)1.78690423
159Increased cerebral lipofuscin (HP:0011813)1.77269424
160Difficulty running (HP:0009046)1.76990135
161Thrombophlebitis (HP:0004418)1.76120902
162Vertigo (HP:0002321)1.75028258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.81281873
2MAP4K13.29454961
3CDC72.90733008
4ERN12.84055647
5CSK2.73052415
6SIK32.70108861
7TXK2.69391732
8EEF2K2.61763685
9FES2.61714078
10MAP3K102.51973092
11NEK22.50430351
12PRPF4B2.32335874
13TEC2.18850451
14STK162.16679721
15SMG12.11775864
16EPHB12.09670842
17TAOK12.07975661
18NME22.07224747
19FGR1.99609611
20DYRK31.97231678
21VRK11.94749679
22CDK121.90396379
23KSR21.84822761
24MAP3K31.84139759
25WEE11.81838771
26STK101.77478689
27BTK1.74453696
28MKNK21.71017557
29HCK1.69684598
30RPS6KA41.65331556
31CDK81.63654915
32GRK61.62796822
33PIM11.58738101
34PIM21.53654027
35MKNK11.52071460
36TRIB31.51312302
37CDK71.48518797
38ATR1.47985934
39MAP3K11.46681102
40CDK191.43394805
41RPS6KB21.41172839
42MAP3K121.40450975
43BRD41.40001236
44EIF2AK31.38504313
45JAK21.37088377
46ZAP701.35717159
47SRPK11.34482708
48BUB11.24022844
49SIK21.23381245
50ACVR1B1.21766781
51EIF2AK11.20121124
52CDK41.17454920
53PTK61.16876287
54NLK1.16250219
55PASK1.15686839
56IRAK41.14755404
57ITK1.13758400
58MAP3K131.13184477
59CLK11.13090531
60MAP3K111.10175133
61MAP2K31.08986160
62SYK1.08813714
63MARK21.08320116
64IKBKB1.02638938
65IRAK21.02127231
66TLK11.01936134
67YES10.99084141
68IKBKE0.98469483
69MAP3K20.95780818
70TSSK60.93226797
71PRKD20.93117953
72TBK10.93009791
73MAP3K140.92776789
74MST40.92307011
75TESK10.91567112
76STK40.91562119
77JAK30.91435773
78TAOK20.90449388
79IRAK10.88831407
80MARK30.86140154
81EIF2AK20.84894863
82MATK0.84220237
83BMX0.83532822
84CHEK20.81239050
85PDK10.80723832
86KIT0.79083432
87PDPK10.78226050
88TGFBR10.78175162
89AURKB0.78120903
90BRSK20.77794599
91RAF10.77625395
92TAOK30.77505267
93HIPK20.77334251
94PLK40.76335776
95JAK10.75920819
96FGFR40.75461173
97RPS6KA60.75339947
98CHUK0.73230695
99PLK10.72890026
100TYK20.72773219
101TESK20.72077470
102TTK0.72035722
103CDK60.70988583
104MAP3K60.70974369
105CHEK10.70124576
106RPS6KA50.69620774
107ALK0.69511883
108MAP3K80.68751769
109STK110.68305652
110ZAK0.68019994
111MAP2K40.67351371
112DYRK1B0.65530549
113TGFBR20.65477973
114LCK0.65332208
115RPS6KC10.64903667
116RPS6KL10.64903667
117ATM0.64842511
118FLT30.62948015
119PAK40.62489629
120CCNB10.62310877
121MAPK40.62084002
122KSR10.60897214
123MAP3K50.60830403
124TNIK0.59190701
125FYN0.58523558
126LYN0.58403241
127PRKG20.54702554
128CSF1R0.53315023
129SGK30.48444756
130CDK20.47914775
131SIK10.47012071
132MAP3K70.46554204
133MAP2K20.46512849
134MAPK110.46166816
135TNK20.45290403
136FGFR30.45260691
137RPS6KA10.45026397
138MAP2K60.44934470
139LRRK20.44134023
140MAPKAPK50.42438619
141RET0.42226335
142BLK0.41758435
143MAPKAPK20.41506714
144STK380.41494025
145CSNK2A20.40441781
146MAPK120.39906006
147PRKCQ0.34783278
148PRKCZ0.34601827
149CDC42BPA0.31182669
150PIK3CG0.29445655
151PKN20.26650645

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18354319
2Ribosome_Homo sapiens_hsa030103.28818662
3Mismatch repair_Homo sapiens_hsa034303.00407650
4Base excision repair_Homo sapiens_hsa034102.64905266
5Primary immunodeficiency_Homo sapiens_hsa053402.63313657
6Staphylococcus aureus infection_Homo sapiens_hsa051502.56234258
7Spliceosome_Homo sapiens_hsa030402.53828189
8Homologous recombination_Homo sapiens_hsa034402.52982815
9Fanconi anemia pathway_Homo sapiens_hsa034602.21516808
10Non-homologous end-joining_Homo sapiens_hsa034502.21174495
11Cell cycle_Homo sapiens_hsa041102.05073274
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91298097
13RNA polymerase_Homo sapiens_hsa030201.85452623
14Nucleotide excision repair_Homo sapiens_hsa034201.78877821
15Malaria_Homo sapiens_hsa051441.77027756
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73667683
17RNA transport_Homo sapiens_hsa030131.72845642
18Pyrimidine metabolism_Homo sapiens_hsa002401.69774161
19Herpes simplex infection_Homo sapiens_hsa051681.66956446
20Basal transcription factors_Homo sapiens_hsa030221.59552062
21Autoimmune thyroid disease_Homo sapiens_hsa053201.57013907
22RNA degradation_Homo sapiens_hsa030181.52581333
23Measles_Homo sapiens_hsa051621.51898845
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.51012075
25mRNA surveillance pathway_Homo sapiens_hsa030151.44236146
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.40873981
27Acute myeloid leukemia_Homo sapiens_hsa052211.39785603
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36985312
29Leishmaniasis_Homo sapiens_hsa051401.34027117
30T cell receptor signaling pathway_Homo sapiens_hsa046601.33538250
31Viral myocarditis_Homo sapiens_hsa054161.30454564
32Phagosome_Homo sapiens_hsa041451.29633937
33African trypanosomiasis_Homo sapiens_hsa051431.28426703
34B cell receptor signaling pathway_Homo sapiens_hsa046621.22502554
35p53 signaling pathway_Homo sapiens_hsa041151.20619495
36Osteoclast differentiation_Homo sapiens_hsa043801.20477601
37Hepatitis B_Homo sapiens_hsa051611.19712538
38Hematopoietic cell lineage_Homo sapiens_hsa046401.19011206
39Antigen processing and presentation_Homo sapiens_hsa046121.18789887
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17276981
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17070574
42One carbon pool by folate_Homo sapiens_hsa006701.15678741
43Epstein-Barr virus infection_Homo sapiens_hsa051691.13023912
44Chronic myeloid leukemia_Homo sapiens_hsa052201.11719816
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09443075
46Type I diabetes mellitus_Homo sapiens_hsa049401.08602473
47Renal cell carcinoma_Homo sapiens_hsa052111.08458424
48Regulation of autophagy_Homo sapiens_hsa041401.06534289
49HTLV-I infection_Homo sapiens_hsa051661.05238490
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05071759
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04786266
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04770645
53Colorectal cancer_Homo sapiens_hsa052101.02250622
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99110984
55Influenza A_Homo sapiens_hsa051640.98942357
56Legionellosis_Homo sapiens_hsa051340.98422166
57Purine metabolism_Homo sapiens_hsa002300.95879480
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95104662
59Systemic lupus erythematosus_Homo sapiens_hsa053220.95090819
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.93476187
61Viral carcinogenesis_Homo sapiens_hsa052030.92421604
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89836269
63Endocytosis_Homo sapiens_hsa041440.89606088
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87869999
65Apoptosis_Homo sapiens_hsa042100.86433743
66Proteasome_Homo sapiens_hsa030500.86193171
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83794369
68Toxoplasmosis_Homo sapiens_hsa051450.82052423
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.81865695
70Small cell lung cancer_Homo sapiens_hsa052220.79534797
71Inositol phosphate metabolism_Homo sapiens_hsa005620.78504809
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77079071
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75613969
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74087456
75Shigellosis_Homo sapiens_hsa051310.73708213
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72793863
77Thyroid cancer_Homo sapiens_hsa052160.72195079
78TNF signaling pathway_Homo sapiens_hsa046680.71883553
79Pentose phosphate pathway_Homo sapiens_hsa000300.71259931
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70817937
81Choline metabolism in cancer_Homo sapiens_hsa052310.70665021
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.69659392
83Non-small cell lung cancer_Homo sapiens_hsa052230.69073326
84HIF-1 signaling pathway_Homo sapiens_hsa040660.68238607
85mTOR signaling pathway_Homo sapiens_hsa041500.67540938
86Other glycan degradation_Homo sapiens_hsa005110.66462465
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.63769491
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63471705
89N-Glycan biosynthesis_Homo sapiens_hsa005100.62406782
90Notch signaling pathway_Homo sapiens_hsa043300.60173415
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.59575185
92Allograft rejection_Homo sapiens_hsa053300.59383832
93Pancreatic cancer_Homo sapiens_hsa052120.59094527
94Sulfur relay system_Homo sapiens_hsa041220.58247201
95ErbB signaling pathway_Homo sapiens_hsa040120.58189311
96Insulin signaling pathway_Homo sapiens_hsa049100.58118496
97Insulin resistance_Homo sapiens_hsa049310.57256732
98Tuberculosis_Homo sapiens_hsa051520.55460768
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.54927525
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54920850
101Rap1 signaling pathway_Homo sapiens_hsa040150.54168323
102Asthma_Homo sapiens_hsa053100.53267704
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.53071375
104GnRH signaling pathway_Homo sapiens_hsa049120.52851923
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50646571
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50534909
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49950119
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49417118
109Amoebiasis_Homo sapiens_hsa051460.49305019
110Folate biosynthesis_Homo sapiens_hsa007900.48939765
111Prolactin signaling pathway_Homo sapiens_hsa049170.48861838
112Hepatitis C_Homo sapiens_hsa051600.48857088
113Pertussis_Homo sapiens_hsa051330.48233709
114FoxO signaling pathway_Homo sapiens_hsa040680.46371757
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46169316
116Endometrial cancer_Homo sapiens_hsa052130.45712360
117MAPK signaling pathway_Homo sapiens_hsa040100.44535059
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44467002
119MicroRNAs in cancer_Homo sapiens_hsa052060.44246100
120Salmonella infection_Homo sapiens_hsa051320.44052312
121Platelet activation_Homo sapiens_hsa046110.42283629
122Lysosome_Homo sapiens_hsa041420.42220458
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41916601
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41422768
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40999227
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40398932
127Dorso-ventral axis formation_Homo sapiens_hsa043200.38672077
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37579331
129Bladder cancer_Homo sapiens_hsa052190.36619348
130Pathways in cancer_Homo sapiens_hsa052000.36177264
131Prostate cancer_Homo sapiens_hsa052150.36099706
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35456376
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34682886
134Graft-versus-host disease_Homo sapiens_hsa053320.34477304
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.34187332
136Chemokine signaling pathway_Homo sapiens_hsa040620.33168312
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32522056
138VEGF signaling pathway_Homo sapiens_hsa043700.31434791

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