FREM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)8.25052235
2mesenchymal-epithelial cell signaling (GO:0060638)6.95149738
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.52624679
4very-low-density lipoprotein particle assembly (GO:0034379)6.50014035
5cell proliferation involved in metanephros development (GO:0072203)6.34151657
6plasma lipoprotein particle assembly (GO:0034377)6.22873375
7low-density lipoprotein particle remodeling (GO:0034374)5.61662340
8negative regulation of fibrinolysis (GO:0051918)5.59301374
9cell proliferation involved in kidney development (GO:0072111)5.47517788
10planar cell polarity pathway involved in neural tube closure (GO:0090179)5.46205695
11bone trabecula formation (GO:0060346)5.40402822
12protein-lipid complex assembly (GO:0065005)5.38179110
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.31903122
14regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.28831623
15regulation of non-canonical Wnt signaling pathway (GO:2000050)5.24672706
16sequestering of extracellular ligand from receptor (GO:0035581)5.21870699
17intestinal cholesterol absorption (GO:0030299)5.20660546
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.19317018
19radial glial cell differentiation (GO:0060019)5.11405471
20mesenchymal cell proliferation (GO:0010463)5.10699830
21regulation of apoptotic cell clearance (GO:2000425)5.03098235
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.95226847
23regulation of protein activation cascade (GO:2000257)4.93316346
24regulation of complement activation (GO:0030449)4.88867080
25protein-lipid complex remodeling (GO:0034368)4.81929677
26macromolecular complex remodeling (GO:0034367)4.81929677
27plasma lipoprotein particle remodeling (GO:0034369)4.81929677
28peptidyl-glutamic acid carboxylation (GO:0017187)4.76322633
29protein carboxylation (GO:0018214)4.76322633
30regulation of cholesterol esterification (GO:0010872)4.74203574
31regulation of fibrinolysis (GO:0051917)4.69561819
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.66558171
33plasma lipoprotein particle organization (GO:0071827)4.61857938
34head development (GO:0060322)4.60633722
35somite development (GO:0061053)4.56904488
36blood coagulation, intrinsic pathway (GO:0007597)4.53885126
37cholesterol efflux (GO:0033344)4.47103237
38embryonic retina morphogenesis in camera-type eye (GO:0060059)4.37295116
39cranial suture morphogenesis (GO:0060363)4.36228105
40protein-lipid complex subunit organization (GO:0071825)4.25419577
41intestinal absorption (GO:0050892)4.19304037
42branching involved in salivary gland morphogenesis (GO:0060445)4.15044884
43convergent extension (GO:0060026)4.14776340
44high-density lipoprotein particle remodeling (GO:0034375)4.14753015
45artery smooth muscle contraction (GO:0014824)4.14612903
46tonic smooth muscle contraction (GO:0014820)4.13228428
47nephron tubule morphogenesis (GO:0072078)4.11744192
48nephron epithelium morphogenesis (GO:0072088)4.11744192
49hindlimb morphogenesis (GO:0035137)4.09180600
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.02931672
51lung epithelium development (GO:0060428)4.02242225
52embryonic foregut morphogenesis (GO:0048617)3.99202343
53proximal/distal pattern formation (GO:0009954)3.98065743
54negative regulation of norepinephrine secretion (GO:0010700)3.93468116
55renal system development (GO:0072001)3.93316311
56negative regulation of catenin import into nucleus (GO:0035414)3.92707931
57mesenchymal cell differentiation (GO:0048762)3.92094352
58paraxial mesoderm development (GO:0048339)3.89181354
59* craniofacial suture morphogenesis (GO:0097094)3.88748727
60reverse cholesterol transport (GO:0043691)3.86155360
61branching involved in prostate gland morphogenesis (GO:0060442)3.86120335
62outer ear morphogenesis (GO:0042473)3.81333401
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.79987316
64plasma lipoprotein particle clearance (GO:0034381)3.79867310
65branching involved in labyrinthine layer morphogenesis (GO:0060670)3.75172017
66mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.72345331
67regulation of establishment of planar polarity (GO:0090175)3.70847181
68embryonic digestive tract morphogenesis (GO:0048557)3.63703555
69regulation of bile acid biosynthetic process (GO:0070857)3.62581755
70embryonic cranial skeleton morphogenesis (GO:0048701)3.62144525
71embryonic hindlimb morphogenesis (GO:0035116)3.61108453
72regulation of plasminogen activation (GO:0010755)3.59181826
73regulation of norepinephrine secretion (GO:0014061)3.56126125
74lung-associated mesenchyme development (GO:0060484)3.55536143
75negative regulation of osteoblast proliferation (GO:0033689)3.53689819
76embryonic appendage morphogenesis (GO:0035113)3.52391183
77embryonic limb morphogenesis (GO:0030326)3.52391183
78digestive tract morphogenesis (GO:0048546)3.51799506
79negative regulation of cholesterol transport (GO:0032375)3.51065535
80negative regulation of sterol transport (GO:0032372)3.51065535
81branching involved in ureteric bud morphogenesis (GO:0001658)3.50723951
82mesonephros development (GO:0001823)3.50240801
83midgut development (GO:0007494)3.49519897
84regulation of smoothened signaling pathway (GO:0008589)3.48833220
85negative regulation of smoothened signaling pathway (GO:0045879)3.47797414
86axon extension involved in axon guidance (GO:0048846)3.46700314
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.46700314
88negative regulation of chondrocyte differentiation (GO:0032331)3.46470858
89drinking behavior (GO:0042756)3.45373815
90diacylglycerol metabolic process (GO:0046339)3.44952457
91axis elongation (GO:0003401)3.44622743
92organ induction (GO:0001759)3.44487613
93low-density lipoprotein particle clearance (GO:0034383)3.44326309
94NLS-bearing protein import into nucleus (GO:0006607)3.44020085
95appendage morphogenesis (GO:0035107)3.43746190
96limb morphogenesis (GO:0035108)3.43746190
97G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.43569489
98L-phenylalanine catabolic process (GO:0006559)3.43290673
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43290673
100negative regulation of protein activation cascade (GO:2000258)3.41684733
101heart morphogenesis (GO:0003007)3.41184115
102cellular response to cholesterol (GO:0071397)3.40689195
103negative regulation of axon extension involved in axon guidance (GO:0048843)3.40177017
104embryonic forelimb morphogenesis (GO:0035115)3.37436617
105anatomical structure regression (GO:0060033)3.36774808
106lipoprotein metabolic process (GO:0042157)3.35658092
107positive regulation of hormone biosynthetic process (GO:0046886)3.35226311
108glomerular filtration (GO:0003094)3.35026634
109epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.33580433
110glial cell migration (GO:0008347)3.32469501
111mesenchymal cell differentiation involved in renal system development (GO:2001012)3.30630332
112mesenchymal cell differentiation involved in kidney development (GO:0072161)3.30630332
113mesodermal cell differentiation (GO:0048333)3.30131373
114neurotransmitter-gated ion channel clustering (GO:0072578)3.28485353
115negative regulation of stem cell proliferation (GO:2000647)3.28028138
116prostate gland epithelium morphogenesis (GO:0060740)3.27472745
117dermatan sulfate biosynthetic process (GO:0030208)3.26958599
118hippo signaling (GO:0035329)3.26525681
119dorsal/ventral axis specification (GO:0009950)3.26221570
120regulation of morphogenesis of a branching structure (GO:0060688)3.26046448
121regulation of keratinocyte proliferation (GO:0010837)3.25719125
122positive regulation of smoothened signaling pathway (GO:0045880)3.25654812
123keratinocyte proliferation (GO:0043616)3.24446175
124non-canonical Wnt signaling pathway (GO:0035567)3.20970417
125positive regulation of mesenchymal cell proliferation (GO:0002053)3.18682482
126mesenchyme morphogenesis (GO:0072132)3.18408596
127positive regulation of hormone metabolic process (GO:0032352)3.17288636
128positive regulation of dendritic spine morphogenesis (GO:0061003)3.16524335
129lipoprotein transport (GO:0042953)3.16450398
130SMAD protein signal transduction (GO:0060395)3.15670303
131regulation of cholesterol homeostasis (GO:2000188)3.15568529
132complement activation, alternative pathway (GO:0006957)3.14873532
133negative regulation of sodium ion transport (GO:0010766)3.14353491
134regulation of mesenchymal cell proliferation (GO:0010464)3.13463880
135extracellular regulation of signal transduction (GO:1900115)3.13203352
136extracellular negative regulation of signal transduction (GO:1900116)3.13203352
137primitive streak formation (GO:0090009)3.13043133
138branch elongation of an epithelium (GO:0060602)3.12121529
139renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.09443049
140cell differentiation involved in kidney development (GO:0061005)3.09430477
141organ formation (GO:0048645)3.09277719
142cell migration involved in heart development (GO:0060973)3.07931330
143hair follicle morphogenesis (GO:0031069)3.07764403
144otic vesicle formation (GO:0030916)3.06587930
145respiratory tube development (GO:0030323)3.06296340
146regulation of chondrocyte differentiation (GO:0032330)3.05580823
147regulation of organ formation (GO:0003156)3.03815663
148metanephric mesenchyme development (GO:0072075)3.03792293
149response to prostaglandin (GO:0034694)3.03678141
150regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.03171038
151dermatan sulfate metabolic process (GO:0030205)3.02815632
152forelimb morphogenesis (GO:0035136)3.02546388
153insulin-like growth factor receptor signaling pathway (GO:0048009)3.00127753
154polarized epithelial cell differentiation (GO:0030859)2.98578263
155embryonic skeletal system development (GO:0048706)2.98546659
156renal tubule morphogenesis (GO:0061333)2.97928086
157vascular smooth muscle contraction (GO:0014829)2.97845393
158anterior/posterior axis specification (GO:0009948)2.97240347
159negative regulation of astrocyte differentiation (GO:0048712)2.95926542
160positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.94210394
161vitamin transmembrane transport (GO:0035461)2.91613879
162positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.91013218
163erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90861849
164L-phenylalanine metabolic process (GO:0006558)2.90861849
165cholesterol homeostasis (GO:0042632)2.85239317
166chondrocyte proliferation (GO:0035988)2.84131635
167positive regulation of extracellular matrix organization (GO:1903055)2.83902832
168sterol homeostasis (GO:0055092)2.82673078
169phosphate ion homeostasis (GO:0055062)2.81097600
170trivalent inorganic anion homeostasis (GO:0072506)2.81097600
171regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.76468604
172endocardial cushion development (GO:0003197)2.75307246
173sterol transport (GO:0015918)2.75244601
174cholesterol transport (GO:0030301)2.75244601
175eye photoreceptor cell differentiation (GO:0001754)2.74674103
176photoreceptor cell differentiation (GO:0046530)2.74674103
177cellular sodium ion homeostasis (GO:0006883)2.72669113
178positive regulation of steroid metabolic process (GO:0045940)2.72033929
179L-ascorbic acid metabolic process (GO:0019852)2.71193738
180transepithelial transport (GO:0070633)2.70733742
181limb bud formation (GO:0060174)2.70597627
182regulation of cholesterol biosynthetic process (GO:0045540)2.70047218
183negative regulation of complement activation (GO:0045916)2.68713435
184regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.68205271
185notochord development (GO:0030903)2.65843872
186C4-dicarboxylate transport (GO:0015740)2.61565789
187positive regulation of male gonad development (GO:2000020)2.60302378
188phospholipid efflux (GO:0033700)2.58994663
189response to follicle-stimulating hormone (GO:0032354)2.58428771
190anterior/posterior axis specification, embryo (GO:0008595)2.58334000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.58631012
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.24579737
3* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.70964401
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.85537985
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.29310477
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.27737540
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.04022654
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64407442
9RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.55919701
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.54214828
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.45854882
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.44075241
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40552533
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.39998897
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.39436499
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34842466
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.34581705
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32657588
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32657588
20EZH2_22144423_ChIP-Seq_EOC_Human2.30863774
21GBX2_23144817_ChIP-Seq_PC3_Human2.23469884
22* HNF4A_19822575_ChIP-Seq_HepG2_Human2.23417464
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21030663
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20772664
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17748288
26AR_21572438_ChIP-Seq_LNCaP_Human2.12425414
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07647889
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07330494
29AR_21909140_ChIP-Seq_LNCAP_Human2.03363140
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02223944
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99446146
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99145694
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97465959
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.96704232
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94418898
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.93708165
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.88795248
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83880778
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.82975935
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82003457
41* SMAD3_21741376_ChIP-Seq_HESCs_Human1.76926600
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76886387
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75871849
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.74290402
45* ISL1_27105846_Chip-Seq_CPCs_Mouse1.73413989
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73324745
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.72166060
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70174895
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.67135496
50FUS_26573619_Chip-Seq_HEK293_Human1.64551650
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64268723
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63954497
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60582226
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58967190
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.55344114
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54978867
57TBX3_20139965_ChIP-Seq_MESCs_Mouse1.54327808
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53003958
59* SMAD4_21741376_ChIP-Seq_HESCs_Human1.52390708
60* P300_19829295_ChIP-Seq_ESCs_Human1.51635734
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.50929159
62ZNF274_21170338_ChIP-Seq_K562_Hela1.48612159
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48455136
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47412961
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.47118655
66GATA4_25053715_ChIP-Seq_YYC3_Human1.46295730
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45545334
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45537119
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45300826
70SMAD4_21799915_ChIP-Seq_A2780_Human1.44316228
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43624474
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.43054291
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42042912
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41720118
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41667519
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41395055
77EWS_26573619_Chip-Seq_HEK293_Human1.40849650
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40490572
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40490572
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39782441
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.39621013
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39185037
83* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38010025
84TP53_18474530_ChIP-ChIP_U2OS_Human1.37871681
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37700363
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37071659
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33465050
88TAF15_26573619_Chip-Seq_HEK293_Human1.32345989
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.30647297
90CLOCK_20551151_ChIP-Seq_293T_Human1.30079677
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29395181
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29254424
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.28397964
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27562264
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.27381003
96BCAT_22108803_ChIP-Seq_LS180_Human1.26974213
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26392752
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25476787
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.23794878
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.23700928
101RNF2_27304074_Chip-Seq_NSC_Mouse1.23087157
102AHR_22903824_ChIP-Seq_MCF-7_Human1.22980107
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22897715
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.22063408
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21891491
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.21513345
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21156954
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19785653
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19404139
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19002904
111RXR_22108803_ChIP-Seq_LS180_Human1.18348811
112* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17347166
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14659006
114IGF1R_20145208_ChIP-Seq_DFB_Human1.14436944
115VDR_22108803_ChIP-Seq_LS180_Human1.13434876
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.13125814
117DROSHA_22980978_ChIP-Seq_HELA_Human1.12111851
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11895665
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10347648
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10347648
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10347648
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08931124
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08146443
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07410850
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06163335
126AR_19668381_ChIP-Seq_PC3_Human1.05635169
127BRD4_25478319_ChIP-Seq_HGPS_Human1.05065732
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04094341
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03367419
130SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03195422
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02772667
132TP53_16413492_ChIP-PET_HCT116_Human1.02418672
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.02136757
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01447169
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00276368
136* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99973531
137SOX9_26525672_Chip-Seq_HEART_Mouse0.99726183
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99442158
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99442158
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98493219
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98289132
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98156312
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96685968
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.96473429
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95808399
146TCF4_22108803_ChIP-Seq_LS180_Human0.95332229
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93307472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.29960216
2MP0002938_white_spotting4.13887679
3MP0000566_synostosis4.10576837
4MP0010030_abnormal_orbit_morphology3.68061746
5MP0003195_calcinosis3.64033688
6MP0003890_abnormal_embryonic-extraembry3.60314951
7MP0009250_abnormal_appendicular_skeleto3.23035062
8MP0002139_abnormal_hepatobiliary_system3.05638652
9MP0005360_urolithiasis2.98415539
10MP0004272_abnormal_basement_membrane2.90211572
11MP0003122_maternal_imprinting2.84691299
12MP0005187_abnormal_penis_morphology2.80244654
13MP0005365_abnormal_bile_salt2.79223878
14MP0003385_abnormal_body_wall2.73289402
15MP0003942_abnormal_urinary_system2.72011239
16MP0001299_abnormal_eye_distance/2.67864411
17MP0001666_abnormal_nutrient_absorption2.59675198
18MP0005248_abnormal_Harderian_gland2.53886507
19MP0000428_abnormal_craniofacial_morphol2.47664032
20MP0000537_abnormal_urethra_morphology2.44084193
21MP0000049_abnormal_middle_ear2.36977374
22MP0002282_abnormal_trachea_morphology2.33131808
23MP0003937_abnormal_limbs/digits/tail_de2.30182190
24MP0009053_abnormal_anal_canal2.26842058
25MP0010329_abnormal_lipoprotein_level2.25151802
26MP0002249_abnormal_larynx_morphology2.21084107
27MP0006054_spinal_hemorrhage2.16521660
28MP0005085_abnormal_gallbladder_physiolo2.08330335
29MP0008438_abnormal_cutaneous_collagen2.06970418
30MP0000534_abnormal_ureter_morphology2.04065619
31MP0003935_abnormal_craniofacial_develop2.01048840
32MP0003755_abnormal_palate_morphology1.96612793
33MP0003121_genomic_imprinting1.90697479
34MP0002108_abnormal_muscle_morphology1.89959063
35MP0002932_abnormal_joint_morphology1.84346812
36MP0005257_abnormal_intraocular_pressure1.83761965
37MP0005508_abnormal_skeleton_morphology1.78510242
38MP0002116_abnormal_craniofacial_bone1.77779525
39MP0003283_abnormal_digestive_organ1.76533634
40MP0000762_abnormal_tongue_morphology1.76478867
41MP0003123_paternal_imprinting1.75452069
42MP0003938_abnormal_ear_development1.74313471
43* MP0001293_anophthalmia1.67804338
44MP0003315_abnormal_perineum_morphology1.66463170
45MP0004134_abnormal_chest_morphology1.66185540
46MP0003941_abnormal_skin_development1.60756662
47MP0003115_abnormal_respiratory_system1.59247059
48MP0001346_abnormal_lacrimal_gland1.58421352
49MP0005408_hypopigmentation1.58272302
50MP0003252_abnormal_bile_duct1.54762786
51* MP0002109_abnormal_limb_morphology1.54187378
52MP0005367_renal/urinary_system_phenotyp1.51144245
53MP0000516_abnormal_urinary_system1.51144245
54MP0000432_abnormal_head_morphology1.49708213
55MP0010368_abnormal_lymphatic_system1.49244995
56MP0003136_yellow_coat_color1.48958862
57MP0004264_abnormal_extraembryonic_tissu1.48522607
58MP0001915_intracranial_hemorrhage1.46177226
59MP0002177_abnormal_outer_ear1.43359950
60MP0000163_abnormal_cartilage_morphology1.43135596
61MP0000579_abnormal_nail_morphology1.39098890
62MP0003868_abnormal_feces_composition1.35603312
63MP0005670_abnormal_white_adipose1.34868049
64MP0002115_abnormal_skeleton_extremities1.34022584
65MP0002233_abnormal_nose_morphology1.32618939
66MP0000462_abnormal_digestive_system1.32387639
67MP0005409_darkened_coat_color1.28320203
68MP0003705_abnormal_hypodermis_morpholog1.25299001
69* MP0001286_abnormal_eye_development1.24407815
70MP0000733_abnormal_muscle_development1.18902728
71MP0009384_cardiac_valve_regurgitation1.18636610
72MP0005275_abnormal_skin_tensile1.18506519
73MP0000427_abnormal_hair_cycle1.16346946
74MP0008875_abnormal_xenobiotic_pharmacok1.14856046
75MP0001661_extended_life_span1.14154696
76MP0002132_abnormal_respiratory_system1.14027106
77MP0006292_abnormal_olfactory_placode1.12547272
78MP0000569_abnormal_digit_pigmentation1.11933458
79MP0002102_abnormal_ear_morphology1.10775491
80MP0002114_abnormal_axial_skeleton1.09730453
81MP0001177_atelectasis1.04917752
82MP0001270_distended_abdomen1.04119568
83MP0002234_abnormal_pharynx_morphology1.03878570
84MP0002113_abnormal_skeleton_development1.03791091
85MP0009697_abnormal_copulation1.03629148
86MP0000647_abnormal_sebaceous_gland1.02798477
87MP0005171_absent_coat_pigmentation1.02182797
88MP0001958_emphysema0.99170090
89MP0002896_abnormal_bone_mineralization0.99121642
90MP0009703_decreased_birth_body0.97263740
91MP0000751_myopathy0.97217701
92MP0002089_abnormal_postnatal_growth/wei0.96979051
93MP0003878_abnormal_ear_physiology0.96804631
94MP0005377_hearing/vestibular/ear_phenot0.96804631
95MP0001175_abnormal_lung_morphology0.95923980
96MP0002933_joint_inflammation0.95589153
97MP0002111_abnormal_tail_morphology0.94895387
98MP0002085_abnormal_embryonic_tissue0.93171151
99MP0005167_abnormal_blood-brain_barrier0.92725930
100* MP0001340_abnormal_eyelid_morphology0.92568203
101MP0003119_abnormal_digestive_system0.89437007
102MP0002098_abnormal_vibrissa_morphology0.88684251
103MP0005084_abnormal_gallbladder_morpholo0.88379507
104MP0004197_abnormal_fetal_growth/weight/0.86908697
105MP0002925_abnormal_cardiovascular_devel0.86754780
106MP0003943_abnormal_hepatobiliary_system0.85123917
107MP0010630_abnormal_cardiac_muscle0.83764746
108* MP0002092_abnormal_eye_morphology0.83398686
109MP0000383_abnormal_hair_follicle0.81923310
110MP0003984_embryonic_growth_retardation0.80723071
111MP0002088_abnormal_embryonic_growth/wei0.79157323
112MP0000613_abnormal_salivary_gland0.78926193
113MP0002751_abnormal_autonomic_nervous0.78320262
114MP0004043_abnormal_pH_regulation0.77833143
115MP0002128_abnormal_blood_circulation0.77639366
116MP0000767_abnormal_smooth_muscle0.77155777
117MP0003861_abnormal_nervous_system0.77030585
118MP0001672_abnormal_embryogenesis/_devel0.76591424
119MP0005380_embryogenesis_phenotype0.76591424
120MP0002697_abnormal_eye_size0.75302086
121MP0002118_abnormal_lipid_homeostasis0.75175819
122MP0000639_abnormal_adrenal_gland0.75126721
123MP0001984_abnormal_olfaction0.74946176
124MP0003279_aneurysm0.74382263
125MP0003936_abnormal_reproductive_system0.72858518
126MP0002295_abnormal_pulmonary_circulatio0.72812784
127MP0002081_perinatal_lethality0.72777242
128MP0005646_abnormal_pituitary_gland0.72710232
129MP0005076_abnormal_cell_differentiation0.72344076
130MP0008775_abnormal_heart_ventricle0.72278585
131MP0002168_other_aberrant_phenotype0.72150131
132MP0004233_abnormal_muscle_weight0.71407538
133MP0005075_abnormal_melanosome_morpholog0.71027277
134MP0002084_abnormal_developmental_patter0.70713763
135MP0001243_abnormal_dermal_layer0.68628833
136MP0001324_abnormal_eye_pigmentation0.68522392
137MP0001529_abnormal_vocalization0.68073456
138MP0002086_abnormal_extraembryonic_tissu0.67801928
139MP0010307_abnormal_tumor_latency0.66045331
140MP0000778_abnormal_nervous_system0.65682193
141MP0003632_abnormal_nervous_system0.65315777
142MP0005220_abnormal_exocrine_pancreas0.64431734
143MP0005636_abnormal_mineral_homeostasis0.64398523
144MP0000609_abnormal_liver_physiology0.62601053
145MP0005332_abnormal_amino_acid0.62581975
146MP0005394_taste/olfaction_phenotype0.61940797
147MP0005499_abnormal_olfactory_system0.61940797
148MP0009672_abnormal_birth_weight0.61874365
149MP0003567_abnormal_fetal_cardiomyocyte0.61721867
150MP0000266_abnormal_heart_morphology0.60910976

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.71486665
2Short 4th metacarpal (HP:0010044)7.56562952
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)7.56562952
4Abnormality of the parietal bone (HP:0002696)6.06103277
5Abnormality of the 4th metacarpal (HP:0010012)5.35655013
6* Midline defect of the nose (HP:0004122)5.26423841
7Prolonged partial thromboplastin time (HP:0003645)5.19010025
8Complement deficiency (HP:0004431)4.08340149
9Abnormal tarsal ossification (HP:0008369)4.07609988
10Hypobetalipoproteinemia (HP:0003563)4.06372637
11Small epiphyses (HP:0010585)3.99409428
12Broad metatarsal (HP:0001783)3.95893894
13Shallow orbits (HP:0000586)3.95242573
14Joint hemorrhage (HP:0005261)3.92476177
15Acanthocytosis (HP:0001927)3.61172423
16Broad palm (HP:0001169)3.60427190
17* Trigonocephaly (HP:0000243)3.55303984
18Potter facies (HP:0002009)3.52828092
19Facial shape deformation (HP:0011334)3.52828092
20Abnormality of carpal bone ossification (HP:0006257)3.52271760
21Irregular epiphyses (HP:0010582)3.49786912
22Abnormality of the pubic bones (HP:0003172)3.44190541
23Abnormality of the common coagulation pathway (HP:0010990)3.43088331
24Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.34689382
25Epiphyseal dysplasia (HP:0002656)3.32899646
26Microglossia (HP:0000171)3.31070051
27Vitreoretinal degeneration (HP:0000655)3.29884786
28Enlarged kidneys (HP:0000105)3.27079074
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.27007574
30Abnormality of the nasal septum (HP:0000419)3.25786441
31Abnormality of the diencephalon (HP:0010662)3.24318946
32Neoplasm of the heart (HP:0100544)3.21626439
33Glomerulonephritis (HP:0000099)3.20177905
34Broad alveolar ridges (HP:0000187)3.13505226
35Hypercholesterolemia (HP:0003124)3.10113637
36Coronal craniosynostosis (HP:0004440)3.09287941
37Abnormal number of incisors (HP:0011064)3.08438133
38Spontaneous abortion (HP:0005268)3.01202981
39Flat acetabular roof (HP:0003180)3.00942926
40Broad toe (HP:0001837)2.89376861
41Partial duplication of the phalanx of hand (HP:0009999)2.85123157
42Supernumerary ribs (HP:0005815)2.82413884
43Broad face (HP:0000283)2.82398651
44Large earlobe (HP:0009748)2.76289558
45Hypolipoproteinemia (HP:0010981)2.75911404
46Increased number of teeth (HP:0011069)2.73058272
47Narrow palate (HP:0000189)2.72189377
48Abnormality of the incisor (HP:0000676)2.66967287
49Epidermoid cyst (HP:0200040)2.66718284
50Menorrhagia (HP:0000132)2.66573731
51Bifid tongue (HP:0010297)2.66258898
52Alacrima (HP:0000522)2.64906583
53Flat capital femoral epiphysis (HP:0003370)2.64532993
54Pancreatic islet-cell hyperplasia (HP:0004510)2.63000142
55Limited elbow extension (HP:0001377)2.59958417
56Abnormal foot bone ossification (HP:0010675)2.59341658
57Myelomeningocele (HP:0002475)2.57708998
58Abnormality of the lumbar spine (HP:0100712)2.57454087
59Mesomelia (HP:0003027)2.56082938
60Exostoses (HP:0100777)2.55912256
61Asymmetry of the thorax (HP:0001555)2.55667456
62Abnormality of complement system (HP:0005339)2.54746046
63Broad hallux (HP:0010055)2.54524106
64Bilateral microphthalmos (HP:0007633)2.53086943
65Supernumerary bones of the axial skeleton (HP:0009144)2.52988377
66Bell-shaped thorax (HP:0001591)2.52919863
67Turricephaly (HP:0000262)2.52826608
68Chorioretinal atrophy (HP:0000533)2.51395840
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.51128368
70Absent epiphyses (HP:0010577)2.51128368
71Short phalanx of the thumb (HP:0009660)2.50860444
72Xanthomatosis (HP:0000991)2.50621164
73Hypoplastic labia majora (HP:0000059)2.50107523
74Abnormality of the labia minora (HP:0012880)2.49838458
75Neonatal short-limb short stature (HP:0008921)2.49516569
76Toxemia of pregnancy (HP:0100603)2.48652570
77Supernumerary spleens (HP:0009799)2.47939820
78Aplasia involving bones of the upper limbs (HP:0009823)2.45380409
79Aplasia of the phalanges of the hand (HP:0009802)2.45380409
80Aplasia involving bones of the extremities (HP:0009825)2.45380409
81Synostosis involving the elbow (HP:0003938)2.45072693
82Humeroradial synostosis (HP:0003041)2.45072693
83Renal duplication (HP:0000075)2.44508881
84Hemorrhage of the eye (HP:0011885)2.42790730
85Sparse lateral eyebrow (HP:0005338)2.41481220
86Depressed nasal tip (HP:0000437)2.41231258
87Cutaneous finger syndactyly (HP:0010554)2.41125590
88Abnormality of the wing of the ilium (HP:0011867)2.40358070
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39734384
90Abnormality of incisor morphology (HP:0011063)2.39121565
91Hypoplasia of the maxilla (HP:0000327)2.37729972
92White forelock (HP:0002211)2.37528649
93Partial duplication of thumb phalanx (HP:0009944)2.36417507
94Concave nail (HP:0001598)2.33767572
95Absent eyebrow (HP:0002223)2.30164096
96Down-sloping shoulders (HP:0200021)2.28664014
97Wide anterior fontanel (HP:0000260)2.23903591
98Infantile muscular hypotonia (HP:0008947)2.23058828
99Abnormality of the labia majora (HP:0012881)2.22470854
100Aplasia cutis congenita (HP:0001057)2.22258826
101Protrusio acetabuli (HP:0003179)2.20599554
102Hepatoblastoma (HP:0002884)2.19471052
103Wide nose (HP:0000445)2.19022487
104Neoplasm of the oral cavity (HP:0100649)2.18189113
105Hypophosphatemic rickets (HP:0004912)2.17066784
106Flared iliac wings (HP:0002869)2.17058319
107Pigmentary retinal degeneration (HP:0001146)2.15947795
108Cupped ribs (HP:0000887)2.15207250
109Broad thumb (HP:0011304)2.14903383
110Decreased lacrimation (HP:0000633)2.12830859
111Medulloblastoma (HP:0002885)2.11794996
112Wide cranial sutures (HP:0010537)2.11245957
113Preaxial foot polydactyly (HP:0001841)2.09595942
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09057486
115Short metatarsal (HP:0010743)2.07754271
116Cutaneous syndactyly (HP:0012725)2.06772277
117Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.06684011
118Diastasis recti (HP:0001540)2.05421156
119* Abnormality of the nasolacrimal system (HP:0000614)2.05329260
120Patchy hypopigmentation of hair (HP:0011365)2.03786964
121Arthropathy (HP:0003040)2.03375345
122Osteomalacia (HP:0002749)2.00248973
123Hypothermia (HP:0002045)1.99121119
124Abnormality of the acetabulum (HP:0003170)1.96789823
125Metaphyseal irregularity (HP:0003025)1.96435008
126Periauricular skin pits (HP:0100277)1.95938998
127Preauricular pit (HP:0004467)1.95938998
128Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95763337
129* Anophthalmia (HP:0000528)1.95657149
130Bifid scrotum (HP:0000048)1.94525300
131Embryonal renal neoplasm (HP:0011794)1.93542455
132Abnormality of the middle phalanges of the hand (HP:0009833)1.92630975
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.92202071
134Deformed sella turcica (HP:0002681)1.90803775
135Broad phalanx (HP:0006009)1.90578037
136Widely patent fontanelles and sutures (HP:0004492)1.89679795
137Choanal stenosis (HP:0000452)1.89046965
138Hypoglycemic coma (HP:0001325)1.87907178
139Broad phalanges of the hand (HP:0009768)1.87675812
140Broad finger (HP:0001500)1.87661034
141Proximal tubulopathy (HP:0000114)1.87544947
142Aqueductal stenosis (HP:0002410)1.87410620
143Broad long bones (HP:0005622)1.87294213
144Renal hypoplasia (HP:0000089)1.87276846
145Ankle contracture (HP:0006466)1.87037621
146Abnormality of the vitreous humor (HP:0004327)1.86313501
147Peritonitis (HP:0002586)1.86094517
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84664868
149Dislocated radial head (HP:0003083)1.84144680
150Hypoalphalipoproteinemia (HP:0003233)1.83383507
151Nephroblastoma (Wilms tumor) (HP:0002667)1.83172520
152Abnormality of the antihelix (HP:0009738)1.82815449
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82696879
154Impaired pain sensation (HP:0007328)1.81970759
155Abnormality of pain sensation (HP:0010832)1.81970759
156Vascular calcification (HP:0004934)1.81930185
157* Nasolacrimal duct obstruction (HP:0000579)1.81810128
158Protruding ear (HP:0000411)1.81686545
159Systemic lupus erythematosus (HP:0002725)1.81424777
160* Abnormality of the lacrimal duct (HP:0011481)1.81267020
161Recurrent corneal erosions (HP:0000495)1.80605944
162Short clavicles (HP:0000894)1.80340667
163Transposition of the great arteries (HP:0001669)1.80228991
164Abnormal connection of the cardiac segments (HP:0011545)1.80228991
165Abnormal ventriculo-arterial connection (HP:0011563)1.80228991
166Gonadal dysgenesis (HP:0000133)1.80205879
167Abnormality of the radial head (HP:0003995)1.78732700
168Papillary thyroid carcinoma (HP:0002895)1.77158295
169Syringomyelia (HP:0003396)1.76537103
170Spinal cord lesions (HP:0100561)1.76537103
171Hemivertebrae (HP:0002937)1.76453497
172Short middle phalanx of the 5th finger (HP:0004220)1.76365371
173Hypoplastic ischia (HP:0003175)1.76098691
174Hyperglycinuria (HP:0003108)1.75600113
175Deep philtrum (HP:0002002)1.74914702
176Abnormal ossification of hand bones (HP:0005921)1.72374379
177Aplasia/Hypoplasia of the clavicles (HP:0006710)1.71374857
178Telecanthus (HP:0000506)1.69988823
179Aortic dissection (HP:0002647)1.69744467
180Abnormal hand bone ossification (HP:0010660)1.69465285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.50376450
2FGFR25.28963434
3EPHA34.88869549
4FGFR44.38652761
5SIK13.70787460
6WNK43.67716381
7DDR23.42554988
8TYRO32.91328356
9PDGFRA2.75238298
10PLK42.65901536
11WNK32.55525465
12FGFR12.53069428
13PKN22.47152119
14CAMK1G2.16007282
15EPHB22.02065905
16ACVR1B1.98583176
17NUAK11.94852505
18STK391.92245583
19STK31.90690896
20CDK121.90207828
21CAMK1D1.88717440
22LATS21.60892376
23DMPK1.57377368
24BMX1.50551567
25FLT31.48575937
26BRD41.48101192
27NEK21.37777070
28AKT31.37756481
29BRSK21.36513204
30RET1.33819968
31TIE11.32964829
32PDGFRB1.32320293
33SIK31.30681556
34PIK3CA1.27505426
35NLK1.21069537
36MKNK11.20025265
37TTN1.17834020
38OBSCN1.15076676
39RIPK11.14048864
40BCR1.08120187
41WNK11.03827603
42MKNK21.03324184
43ERBB31.01879446
44INSRR1.01576488
45MTOR1.01533272
46DYRK1B0.95840990
47CSNK1A1L0.95704130
48ERBB40.93243905
49MAP3K70.92902925
50NTRK20.90643855
51CHEK20.88221911
52TGFBR20.86006985
53ERBB20.85773689
54CDK80.85096506
55SGK30.82757018
56MAP3K40.80811533
57CAMK40.80715108
58SGK20.79355988
59FER0.76904856
60MAP3K100.75387503
61STK38L0.74197985
62EPHA40.73065016
63TGFBR10.72735445
64ICK0.68737590
65MET0.68653311
66ROCK10.68373720
67PTK20.68184633
68CSNK1E0.67799325
69EIF2AK20.67432954
70PRKD30.66563165
71FGR0.65909127
72KSR10.65814732
73CDK90.65056258
74PAK20.63708859
75CASK0.61638880
76TRIB30.59828845
77TNIK0.59459663
78FGFR30.58884096
79EEF2K0.58878601
80PLK30.58473763
81CDK70.58290051
82SGK10.57803730
83ZAK0.57092529
84CDK30.56852966
85PRKCE0.55370552
86ATR0.54346757
87MAPK10.53438395
88CDC42BPA0.53106942
89ADRBK10.52396523
90MELK0.52028693
91PTK60.51608344
92PLK20.51073550
93MARK20.50901686
94MAPK70.50871428
95RPS6KB10.50748991
96MATK0.50492695
97MAPK130.50244017
98VRK20.48969663
99CDC70.48912256
100PNCK0.48494089
101CLK10.47672546
102MAPK80.47243821
103SIK20.47180632
104PRKAA10.46983629
105ATM0.46284914
106CHUK0.45961708
107CDK10.45571429
108MAPK140.44210495
109MAP4K20.43948364
110PRKAA20.43777849
111PRKCH0.43390048
112NME10.42186223
113IGF1R0.41488546
114BRSK10.41426755
115CSNK1G10.41156919
116YES10.40169304
117PASK0.39579748
118CDK40.39555039
119OXSR10.39067987
120SGK2230.37506165
121SGK4940.37506165
122NEK90.37486478
123AKT10.36633564
124VRK10.36542286
125BMPR1B0.36451827
126GSK3B0.36142695
127CDK60.35991356
128DYRK20.35878578
129MAPK100.35761585
130PTK2B0.35275863
131PRKG10.35065859
132MAPKAPK50.34819151
133SRPK10.34642059
134PBK0.34626994
135GSK3A0.34216224
136TAOK20.33999501
137PRKACG0.33455583
138PRKACB0.33419783
139CSNK1D0.32902163
140MAPK150.31451548
141MAP2K40.31329905
142EIF2AK10.30830646
143SRC0.28646749
144TAF10.28159795
145RPS6KA30.26715175
146CSNK2A20.25140735
147ITK0.23925384

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.74535171
2Hedgehog signaling pathway_Homo sapiens_hsa043405.00261536
3Complement and coagulation cascades_Homo sapiens_hsa046104.67414914
4Fat digestion and absorption_Homo sapiens_hsa049753.26646890
5Fatty acid biosynthesis_Homo sapiens_hsa000612.88853502
6Vitamin digestion and absorption_Homo sapiens_hsa049772.79982443
7Steroid biosynthesis_Homo sapiens_hsa001002.66581181
8Wnt signaling pathway_Homo sapiens_hsa043102.63839612
9Hippo signaling pathway_Homo sapiens_hsa043902.45154240
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43398964
11Fatty acid degradation_Homo sapiens_hsa000712.36502186
12ECM-receptor interaction_Homo sapiens_hsa045122.34294585
13Fatty acid metabolism_Homo sapiens_hsa012122.32580214
14Histidine metabolism_Homo sapiens_hsa003402.29665576
15PPAR signaling pathway_Homo sapiens_hsa033202.28611849
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28095962
17TGF-beta signaling pathway_Homo sapiens_hsa043502.24077305
18Propanoate metabolism_Homo sapiens_hsa006402.20957825
19Adherens junction_Homo sapiens_hsa045202.20564668
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.15980854
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.13854568
22Melanoma_Homo sapiens_hsa052181.96562393
23Axon guidance_Homo sapiens_hsa043601.93635030
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89304867
25Pathways in cancer_Homo sapiens_hsa052001.88377565
26Prostate cancer_Homo sapiens_hsa052151.86067710
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.83482186
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83363738
29Proteoglycans in cancer_Homo sapiens_hsa052051.81214855
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.78175728
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75603485
32Protein digestion and absorption_Homo sapiens_hsa049741.68229443
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66489212
34Colorectal cancer_Homo sapiens_hsa052101.65155646
35Lysine degradation_Homo sapiens_hsa003101.63434887
36Arginine biosynthesis_Homo sapiens_hsa002201.61900532
37MicroRNAs in cancer_Homo sapiens_hsa052061.61875882
38Focal adhesion_Homo sapiens_hsa045101.61421091
39Starch and sucrose metabolism_Homo sapiens_hsa005001.57820885
40Dilated cardiomyopathy_Homo sapiens_hsa054141.55529458
41Melanogenesis_Homo sapiens_hsa049161.54203562
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47733916
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46718069
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46707375
45Small cell lung cancer_Homo sapiens_hsa052221.45865857
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45839337
47Butanoate metabolism_Homo sapiens_hsa006501.45020043
48Phenylalanine metabolism_Homo sapiens_hsa003601.44430138
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42047596
50Tyrosine metabolism_Homo sapiens_hsa003501.32888711
51ABC transporters_Homo sapiens_hsa020101.31512800
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28602087
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25888970
54Glycerolipid metabolism_Homo sapiens_hsa005611.25553321
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25317999
56PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24907268
57Bile secretion_Homo sapiens_hsa049761.24890459
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24685533
59Arginine and proline metabolism_Homo sapiens_hsa003301.21345724
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20525401
61Notch signaling pathway_Homo sapiens_hsa043301.17636985
62Endometrial cancer_Homo sapiens_hsa052131.17577647
63Rap1 signaling pathway_Homo sapiens_hsa040151.14570252
64cAMP signaling pathway_Homo sapiens_hsa040241.14384525
65Staphylococcus aureus infection_Homo sapiens_hsa051501.11923486
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11289940
67N-Glycan biosynthesis_Homo sapiens_hsa005101.10938571
68Viral myocarditis_Homo sapiens_hsa054161.10692663
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10019188
70Peroxisome_Homo sapiens_hsa041461.09785444
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08723785
72Retinol metabolism_Homo sapiens_hsa008301.08237005
73Chemical carcinogenesis_Homo sapiens_hsa052041.06972690
74Pyruvate metabolism_Homo sapiens_hsa006201.05807420
75Renin secretion_Homo sapiens_hsa049241.04838744
76HTLV-I infection_Homo sapiens_hsa051661.03535672
77Chronic myeloid leukemia_Homo sapiens_hsa052201.03051239
78Steroid hormone biosynthesis_Homo sapiens_hsa001401.01974445
79Cell cycle_Homo sapiens_hsa041101.00151717
80Type II diabetes mellitus_Homo sapiens_hsa049300.99223223
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98293426
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98270951
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.96092597
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96032218
85Amoebiasis_Homo sapiens_hsa051460.95265617
86Tryptophan metabolism_Homo sapiens_hsa003800.94271135
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.92899604
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91795773
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.91451231
90Systemic lupus erythematosus_Homo sapiens_hsa053220.88421715
91Alcoholism_Homo sapiens_hsa050340.87433789
92Glioma_Homo sapiens_hsa052140.87007714
93One carbon pool by folate_Homo sapiens_hsa006700.86214722
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85551908
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83240043
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82372279
97MAPK signaling pathway_Homo sapiens_hsa040100.81955247
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80607500
99Nitrogen metabolism_Homo sapiens_hsa009100.80245716
100ErbB signaling pathway_Homo sapiens_hsa040120.79171555
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77961316
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76106047
103Ras signaling pathway_Homo sapiens_hsa040140.75052679
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74417122
105Circadian entrainment_Homo sapiens_hsa047130.73184045
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70552584
107Mineral absorption_Homo sapiens_hsa049780.70243983
108Pancreatic cancer_Homo sapiens_hsa052120.69055642
109Ovarian steroidogenesis_Homo sapiens_hsa049130.68501548
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67133265
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66995989
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65925637
113Fatty acid elongation_Homo sapiens_hsa000620.65367363
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61718766
115Cocaine addiction_Homo sapiens_hsa050300.61296166
116Renal cell carcinoma_Homo sapiens_hsa052110.61193290
117Gap junction_Homo sapiens_hsa045400.60969848
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59765223
119Toxoplasmosis_Homo sapiens_hsa051450.59551716
120Insulin resistance_Homo sapiens_hsa049310.58876333
121Estrogen signaling pathway_Homo sapiens_hsa049150.56692455
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.56301549
123Ribosome_Homo sapiens_hsa030100.55384102
124Dorso-ventral axis formation_Homo sapiens_hsa043200.54912747
125Oocyte meiosis_Homo sapiens_hsa041140.54632427
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.53465556
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52932958
128Amphetamine addiction_Homo sapiens_hsa050310.52863836
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.52252008
130Tight junction_Homo sapiens_hsa045300.51395025
131Choline metabolism in cancer_Homo sapiens_hsa052310.50610328
132mTOR signaling pathway_Homo sapiens_hsa041500.50556390
133AMPK signaling pathway_Homo sapiens_hsa041520.49966017
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49486386
135beta-Alanine metabolism_Homo sapiens_hsa004100.48853833
136Cholinergic synapse_Homo sapiens_hsa047250.48093803
137Biosynthesis of amino acids_Homo sapiens_hsa012300.47064177
138Calcium signaling pathway_Homo sapiens_hsa040200.46859049
139Renin-angiotensin system_Homo sapiens_hsa046140.45688750
140mRNA surveillance pathway_Homo sapiens_hsa030150.45389702
141Viral carcinogenesis_Homo sapiens_hsa052030.45345264
142Other glycan degradation_Homo sapiens_hsa005110.45307981
143Non-small cell lung cancer_Homo sapiens_hsa052230.44015740
144FoxO signaling pathway_Homo sapiens_hsa040680.43585358
145Thyroid cancer_Homo sapiens_hsa052160.42901868
146Carbon metabolism_Homo sapiens_hsa012000.40650749
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40428556
148Oxytocin signaling pathway_Homo sapiens_hsa049210.40157134
149Fructose and mannose metabolism_Homo sapiens_hsa000510.39313676
150Platelet activation_Homo sapiens_hsa046110.38385637
151Insulin signaling pathway_Homo sapiens_hsa049100.37983007
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.37447616
153Hepatitis B_Homo sapiens_hsa051610.37389778
154Glutathione metabolism_Homo sapiens_hsa004800.36864541
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.35996804
156Glutamatergic synapse_Homo sapiens_hsa047240.35646352
157Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35588256
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.35479955
159Morphine addiction_Homo sapiens_hsa050320.35463123
160Thyroid hormone synthesis_Homo sapiens_hsa049180.34999069
161Metabolic pathways_Homo sapiens_hsa011000.34801771
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34725189
163Glucagon signaling pathway_Homo sapiens_hsa049220.33298858
164Long-term depression_Homo sapiens_hsa047300.33038235
165Insulin secretion_Homo sapiens_hsa049110.32181803
166Dopaminergic synapse_Homo sapiens_hsa047280.31259767
167GnRH signaling pathway_Homo sapiens_hsa049120.31187309
168Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25482868
169Galactose metabolism_Homo sapiens_hsa000520.25478498
170Taste transduction_Homo sapiens_hsa047420.22459940
171Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19361316

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