FREM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.80858690
2glucocorticoid biosynthetic process (GO:0006704)5.79957849
3paraxial mesoderm development (GO:0048339)5.58421632
4response to follicle-stimulating hormone (GO:0032354)5.39498035
5estrogen biosynthetic process (GO:0006703)5.31381708
6C21-steroid hormone biosynthetic process (GO:0006700)5.19325068
7cellular response to antibiotic (GO:0071236)5.16154398
8pre-miRNA processing (GO:0031054)5.12430099
9androgen biosynthetic process (GO:0006702)4.61693825
10Leydig cell differentiation (GO:0033327)4.56076503
11glucocorticoid metabolic process (GO:0008211)4.44487479
12regulation of posttranscriptional gene silencing (GO:0060147)4.43665173
13regulation of gene silencing by miRNA (GO:0060964)4.43665173
14regulation of gene silencing by RNA (GO:0060966)4.43665173
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.40694297
16cellular response to gonadotropin stimulus (GO:0071371)4.20948807
17cardiac myofibril assembly (GO:0055003)4.11582214
18polarized epithelial cell differentiation (GO:0030859)4.09070966
19lateral sprouting from an epithelium (GO:0060601)4.06757716
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.06651925
21positive regulation of hormone biosynthetic process (GO:0046886)3.80153286
22notochord development (GO:0030903)3.79111168
23progesterone metabolic process (GO:0042448)3.78878446
24mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.78471648
25hippo signaling (GO:0035329)3.77874219
26cellular response to toxic substance (GO:0097237)3.69725300
27prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.69448022
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66937839
29establishment of apical/basal cell polarity (GO:0035089)3.54754789
30response to insecticide (GO:0017085)3.52544594
31regulation of hippo signaling (GO:0035330)3.38388196
32positive regulation of hormone metabolic process (GO:0032352)3.34770984
33non-canonical Wnt signaling pathway (GO:0035567)3.32970181
34regulation of cardioblast differentiation (GO:0051890)3.32878130
35hemidesmosome assembly (GO:0031581)3.23858775
36mating behavior (GO:0007617)3.18650969
37ectodermal placode formation (GO:0060788)3.18527508
38C21-steroid hormone metabolic process (GO:0008207)3.18487363
39myofibril assembly (GO:0030239)3.17761006
40establishment of tissue polarity (GO:0007164)3.16916207
41establishment of planar polarity (GO:0001736)3.16916207
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.15659461
43G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.15357992
44positive regulation of SMAD protein import into nucleus (GO:0060391)3.12771541
45embryonic foregut morphogenesis (GO:0048617)3.10335853
46regulation of sister chromatid cohesion (GO:0007063)3.09393282
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.08505715
48establishment of monopolar cell polarity (GO:0061162)3.08505715
49regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.06947821
50lung-associated mesenchyme development (GO:0060484)3.06597360
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.06440033
52nuclear pore organization (GO:0006999)3.04747164
53regulation of centriole replication (GO:0046599)3.04664531
54cardiac cell development (GO:0055006)3.04176202
55head development (GO:0060322)3.04098331
56cell surface receptor signaling pathway involved in heart development (GO:0061311)3.03797917
57regulation of transforming growth factor beta2 production (GO:0032909)3.01117446
58mesenchyme development (GO:0060485)3.01113129
59regulation of establishment of planar polarity (GO:0090175)3.00374314
60outer ear morphogenesis (GO:0042473)2.99070554
61cardiac muscle cell development (GO:0055013)2.98820189
62intestinal epithelial cell development (GO:0060576)2.98022768
63sarcomere organization (GO:0045214)2.97778172
64cochlea morphogenesis (GO:0090103)2.97326947
65limb bud formation (GO:0060174)2.97285174
66mesenchymal to epithelial transition (GO:0060231)2.96758767
67negative regulation of smooth muscle cell differentiation (GO:0051151)2.94944745
68vitamin transmembrane transport (GO:0035461)2.91814629
69collecting duct development (GO:0072044)2.91631436
70anterior/posterior axis specification, embryo (GO:0008595)2.91125997
71nuclear pore complex assembly (GO:0051292)2.90121765
72plasma membrane repair (GO:0001778)2.88184751
73convergent extension (GO:0060026)2.86738590
74adrenal gland development (GO:0030325)2.85268561
75response to gonadotropin (GO:0034698)2.84651914
76establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.84260067
77regulation of SMAD protein import into nucleus (GO:0060390)2.81602188
78desmosome organization (GO:0002934)2.79407282
79heart morphogenesis (GO:0003007)2.78782262
80mesenchyme morphogenesis (GO:0072132)2.76764267
81gastrulation with mouth forming second (GO:0001702)2.75035513
82DNA unwinding involved in DNA replication (GO:0006268)2.74858400
83mitotic sister chromatid cohesion (GO:0007064)2.73643452
84negative regulation of potassium ion transmembrane transport (GO:1901380)2.73002677
85benzene-containing compound metabolic process (GO:0042537)2.71553866
86gap junction assembly (GO:0016264)2.71195554
87dorsal/ventral axis specification (GO:0009950)2.68910211
88positive regulation of male gonad development (GO:2000020)2.68275180
89regulation of stem cell maintenance (GO:2000036)2.68169751
90hormone biosynthetic process (GO:0042446)2.67041983
91negative regulation of DNA repair (GO:0045738)2.66120876
92endocardial cushion morphogenesis (GO:0003203)2.65963606
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65100134
94adult heart development (GO:0007512)2.64374848
95apical protein localization (GO:0045176)2.63846749
96regulation of heart morphogenesis (GO:2000826)2.62916923
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62314326
98androgen metabolic process (GO:0008209)2.61346055
99bone trabecula formation (GO:0060346)2.61113418
100mesenchymal cell proliferation (GO:0010463)2.60956557
101positive regulation of catenin import into nucleus (GO:0035413)2.59269330
102hindlimb morphogenesis (GO:0035137)2.58831833
103proximal/distal pattern formation (GO:0009954)2.58613927
104cell proliferation involved in metanephros development (GO:0072203)2.58105804
105insulin-like growth factor receptor signaling pathway (GO:0048009)2.56331330
106branching involved in salivary gland morphogenesis (GO:0060445)2.56099129
107regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.56024980
108cardiac right ventricle morphogenesis (GO:0003215)2.54570869
109glucocorticoid receptor signaling pathway (GO:0042921)2.54079025
110toxin metabolic process (GO:0009404)2.53907548
111embryonic camera-type eye morphogenesis (GO:0048596)2.52327133
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52080561
113male genitalia development (GO:0030539)2.51045939
114vitamin D metabolic process (GO:0042359)2.50614254
115endocardial cushion development (GO:0003197)2.50562656
116ventricular cardiac muscle cell action potential (GO:0086005)2.50205967
117female genitalia development (GO:0030540)2.49756547
118negative regulation of chondrocyte differentiation (GO:0032331)2.48007906
119regulation of cell fate specification (GO:0042659)2.47334076
120kidney mesenchyme development (GO:0072074)2.47132559
121axis elongation (GO:0003401)2.47116766
122regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.47035609
123estrogen metabolic process (GO:0008210)2.46138227
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.45996088
125intracellular lipid transport (GO:0032365)2.45741623
126regulation of steroid hormone biosynthetic process (GO:0090030)2.45673417
127renal system development (GO:0072001)2.43280970
128embryonic camera-type eye development (GO:0031076)2.42842260
129anterior/posterior axis specification (GO:0009948)2.42778719
130prostate gland growth (GO:0060736)2.42739714
131actomyosin structure organization (GO:0031032)2.42424394
132atrial septum morphogenesis (GO:0060413)2.42251699
133embryonic hindlimb morphogenesis (GO:0035116)2.40499650
134organ growth (GO:0035265)2.40046147
135regulation of RNA export from nucleus (GO:0046831)2.39475405
136outflow tract septum morphogenesis (GO:0003148)2.37875349
137regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.37318882
138epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.37107996
139cardiac muscle contraction (GO:0060048)2.36601942
140mitotic chromosome condensation (GO:0007076)2.36267255
141morphogenesis of an epithelial sheet (GO:0002011)2.36003008
142muscle filament sliding (GO:0030049)2.35992226
143actin-myosin filament sliding (GO:0033275)2.35992226
144otic vesicle formation (GO:0030916)2.35873481
145establishment or maintenance of apical/basal cell polarity (GO:0035088)2.34117416
146establishment or maintenance of bipolar cell polarity (GO:0061245)2.34117416
147presynaptic membrane assembly (GO:0097105)2.33974713
148regulation of male gonad development (GO:2000018)2.31293971
149response to phenylpropanoid (GO:0080184)2.30077879
150genitalia morphogenesis (GO:0035112)2.29911989
151cellular response to growth hormone stimulus (GO:0071378)2.29671173
152epithelial tube branching involved in lung morphogenesis (GO:0060441)2.29300469
153nephron tubule formation (GO:0072079)2.27888927
154cellular response to interferon-alpha (GO:0035457)2.26553950
155negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26021984
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.26021984
157regulation of translation, ncRNA-mediated (GO:0045974)2.26021984
158vagina development (GO:0060068)2.26005494
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.25574447
160genitalia development (GO:0048806)2.24999222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.95692977
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32023336
3E2F7_22180533_ChIP-Seq_HELA_Human4.14405347
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74219396
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73693366
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.51387746
7* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50846153
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48712213
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42110967
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39942648
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.38171589
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.36060993
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34150740
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32028994
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.23798032
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23043792
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23043792
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23043792
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.15220832
20FUS_26573619_Chip-Seq_HEK293_Human2.13989461
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12177542
22SOX2_18555785_ChIP-Seq_MESCs_Mouse2.09450807
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05042880
24ISL1_27105846_Chip-Seq_CPCs_Mouse2.04602515
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04056086
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02304548
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.01979092
28EWS_26573619_Chip-Seq_HEK293_Human1.97182763
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97035641
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94498659
31AR_21909140_ChIP-Seq_LNCAP_Human1.91895857
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88845381
33* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83969671
34* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.80117659
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80075092
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78793334
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76962229
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76397210
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71693776
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71243264
41* GBX2_23144817_ChIP-Seq_PC3_Human1.69463843
42TAF15_26573619_Chip-Seq_HEK293_Human1.67526808
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66337082
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64270626
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.63755848
46ZNF263_19887448_ChIP-Seq_K562_Human1.63059439
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58682957
48* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57956465
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57942065
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.56674578
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.53854416
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.52380868
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51103367
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50581865
55* AHR_22903824_ChIP-Seq_MCF-7_Human1.50491712
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50313043
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48748132
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.47932179
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.47139170
60ER_23166858_ChIP-Seq_MCF-7_Human1.45680532
61TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.43100896
62* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.42159846
63P300_19829295_ChIP-Seq_ESCs_Human1.39989473
64* ARNT_22903824_ChIP-Seq_MCF-7_Human1.39688826
65POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.33940829
66CLOCK_20551151_ChIP-Seq_293T_Human1.30969635
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30319091
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29988758
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29851123
70* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29620814
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28336218
72* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28034753
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.26950233
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26791191
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26364379
76* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25598317
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25509809
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23755696
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23735642
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23663068
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22648454
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.22209019
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21966876
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.21557096
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21330621
86* ESR1_20079471_ChIP-ChIP_T-47D_Human1.21274914
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20862523
88* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20556113
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18950346
90* TP53_20018659_ChIP-ChIP_R1E_Mouse1.18617531
91* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16826520
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.15358585
93* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15021255
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.14603611
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14032127
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.10748018
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.10748018
98* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10000490
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09314653
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08721755
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08532446
102ZNF274_21170338_ChIP-Seq_K562_Hela1.08183006
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06946976
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06525536
105SMAD4_21799915_ChIP-Seq_A2780_Human1.06385581
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06376208
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06202064
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05766928
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.05533542
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05290591
111* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05280478
112* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05280478
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04821713
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04791398
115* ESR2_21235772_ChIP-Seq_MCF-7_Human1.03524126
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03495615
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03438256
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03065461
119RNF2_27304074_Chip-Seq_NSC_Mouse1.01996650
120* GATA3_24758297_ChIP-Seq_MCF-7_Human1.00995745
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99928402
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99442442
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98858442
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98766698
125* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98574877
126CHD1_26751641_Chip-Seq_LNCaP_Human0.98053475
127IGF1R_20145208_ChIP-Seq_DFB_Human0.97900407
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97546747
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96142104
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95866133
131TRIM28_21343339_ChIP-Seq_HEK293_Human0.95812353
132MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95810190
133* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95379400
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95149198
135VDR_22108803_ChIP-Seq_LS180_Human0.95083018
136* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94242509
137PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93990178
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93843949
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93348547
140NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92894127
141* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92880469
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92677832
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92433411
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.89528811
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88766109
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88762773
147* EZH2_27304074_Chip-Seq_ESCs_Mouse0.87268804
148* ESR1_21235772_ChIP-Seq_MCF-7_Human0.86941745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.22247489
2MP0003123_paternal_imprinting2.84538922
3MP0000537_abnormal_urethra_morphology2.65112629
4MP0003122_maternal_imprinting2.40449924
5MP0009053_abnormal_anal_canal2.38689893
6MP0000566_synostosis2.25779134
7MP0008995_early_reproductive_senescence2.16369596
8MP0004272_abnormal_basement_membrane2.16126353
9MP0000639_abnormal_adrenal_gland2.11389087
10MP0003705_abnormal_hypodermis_morpholog2.10873133
11MP0003121_genomic_imprinting2.07659428
12* MP0003941_abnormal_skin_development1.98838585
13MP0003567_abnormal_fetal_cardiomyocyte1.98147416
14MP0003119_abnormal_digestive_system1.97945807
15MP0003942_abnormal_urinary_system1.97241261
16MP0002909_abnormal_adrenal_gland1.96504410
17MP0004084_abnormal_cardiac_muscle1.95165103
18MP0003385_abnormal_body_wall1.94376418
19MP0010368_abnormal_lymphatic_system1.90773782
20MP0008057_abnormal_DNA_replication1.89614286
21MP0002249_abnormal_larynx_morphology1.83071740
22MP0002254_reproductive_system_inflammat1.81096731
23MP0003136_yellow_coat_color1.80475463
24MP0003937_abnormal_limbs/digits/tail_de1.80431017
25MP0004233_abnormal_muscle_weight1.79083636
26MP0005623_abnormal_meninges_morphology1.77795354
27MP0004215_abnormal_myocardial_fiber1.68623308
28MP0003115_abnormal_respiratory_system1.68409880
29* MP0001293_anophthalmia1.65966537
30MP0000462_abnormal_digestive_system1.63667214
31MP0000534_abnormal_ureter_morphology1.63476573
32MP0000516_abnormal_urinary_system1.62740857
33MP0005367_renal/urinary_system_phenotyp1.62740857
34MP0000647_abnormal_sebaceous_gland1.62692953
35MP0009780_abnormal_chondrocyte_physiolo1.61606258
36MP0000428_abnormal_craniofacial_morphol1.60466597
37MP0000049_abnormal_middle_ear1.60445292
38MP0004197_abnormal_fetal_growth/weight/1.53322087
39* MP0003935_abnormal_craniofacial_develop1.52941237
40MP0002084_abnormal_developmental_patter1.51285084
41MP0000383_abnormal_hair_follicle1.47449458
42MP0010630_abnormal_cardiac_muscle1.46711420
43MP0005377_hearing/vestibular/ear_phenot1.45996809
44MP0003878_abnormal_ear_physiology1.45996809
45MP0003283_abnormal_digestive_organ1.45884877
46MP0000751_myopathy1.44726058
47MP0002837_dystrophic_cardiac_calcinosis1.44333142
48MP0002160_abnormal_reproductive_system1.43795983
49* MP0002085_abnormal_embryonic_tissue1.42744312
50MP0002653_abnormal_ependyma_morphology1.42672217
51MP0000762_abnormal_tongue_morphology1.40362049
52MP0003890_abnormal_embryonic-extraembry1.39949576
53MP0005187_abnormal_penis_morphology1.39860535
54MP0004145_abnormal_muscle_electrophysio1.39150342
55MP0003755_abnormal_palate_morphology1.35664281
56MP0002932_abnormal_joint_morphology1.35382968
57MP0002233_abnormal_nose_morphology1.35194487
58MP0005076_abnormal_cell_differentiation1.32672980
59MP0005380_embryogenesis_phenotype1.32087746
60MP0001672_abnormal_embryogenesis/_devel1.32087746
61MP0003693_abnormal_embryo_hatching1.31674504
62MP0001661_extended_life_span1.31570816
63MP0009250_abnormal_appendicular_skeleto1.28302089
64* MP0002697_abnormal_eye_size1.27171301
65MP0002234_abnormal_pharynx_morphology1.27001465
66MP0001849_ear_inflammation1.26421873
67MP0010678_abnormal_skin_adnexa1.26272475
68MP0003137_abnormal_impulse_conducting1.26248240
69* MP0000432_abnormal_head_morphology1.24047788
70MP0003984_embryonic_growth_retardation1.23490025
71MP0002088_abnormal_embryonic_growth/wei1.23344995
72* MP0002938_white_spotting1.21925022
73MP0001299_abnormal_eye_distance/1.21230892
74MP0005248_abnormal_Harderian_gland1.19773095
75MP0004087_abnormal_muscle_fiber1.19721463
76MP0005330_cardiomyopathy1.19615873
77MP0006138_congestive_heart_failure1.18447306
78MP0002282_abnormal_trachea_morphology1.18283464
79MP0002127_abnormal_cardiovascular_syste1.17973146
80MP0002111_abnormal_tail_morphology1.17543741
81MP0010094_abnormal_chromosome_stability1.17141072
82MP0000733_abnormal_muscle_development1.16604267
83MP0002116_abnormal_craniofacial_bone1.16536115
84MP0010234_abnormal_vibrissa_follicle1.14256158
85MP0001177_atelectasis1.13888422
86* MP0001286_abnormal_eye_development1.13620900
87MP0003111_abnormal_nucleus_morphology1.13375576
88MP0004957_abnormal_blastocyst_morpholog1.10580811
89MP0000579_abnormal_nail_morphology1.08597525
90MP0003315_abnormal_perineum_morphology1.08329337
91MP0002972_abnormal_cardiac_muscle1.08263754
92MP0002086_abnormal_extraembryonic_tissu1.08181798
93MP0003077_abnormal_cell_cycle1.07232863
94MP0002925_abnormal_cardiovascular_devel1.06685081
95MP0001730_embryonic_growth_arrest1.06447988
96MP0001697_abnormal_embryo_size1.06152934
97MP0000631_abnormal_neuroendocrine_gland1.03696988
98* MP0002092_abnormal_eye_morphology1.02901552
99MP0000750_abnormal_muscle_regeneration1.02394891
100MP0000467_abnormal_esophagus_morphology1.02116039
101MP0004133_heterotaxia1.01464043
102MP0004264_abnormal_extraembryonic_tissu1.01228061
103MP0002102_abnormal_ear_morphology1.00506580
104MP0004858_abnormal_nervous_system0.99410660
105MP0003566_abnormal_cell_adhesion0.99324100
106MP0002108_abnormal_muscle_morphology0.98949828
107MP0002098_abnormal_vibrissa_morphology0.98625559
108MP0009384_cardiac_valve_regurgitation0.98284042
109* MP0009672_abnormal_birth_weight0.98273250
110* MP0003861_abnormal_nervous_system0.98019384
111* MP0009703_decreased_birth_body0.97554212
112MP0008775_abnormal_heart_ventricle0.97423890
113MP0005508_abnormal_skeleton_morphology0.97171028
114* MP0000266_abnormal_heart_morphology0.97130698
115MP0003938_abnormal_ear_development0.97045324
116MP0008789_abnormal_olfactory_epithelium0.96580835
117MP0000427_abnormal_hair_cycle0.95660237
118MP0001346_abnormal_lacrimal_gland0.94862428
119MP0002009_preneoplasia0.92234027
120MP0010352_gastrointestinal_tract_polyps0.92064282
121MP0001544_abnormal_cardiovascular_syste0.91498784
122MP0004782_abnormal_surfactant_physiolog0.89951031
123MP0000778_abnormal_nervous_system0.87719998
124MP0003011_delayed_dark_adaptation0.84156994
125MP0008932_abnormal_embryonic_tissue0.83240433
126MP0002736_abnormal_nociception_after0.79675310
127* MP0005391_vision/eye_phenotype0.78685610
128MP0000377_abnormal_hair_follicle0.77751440
129MP0002184_abnormal_innervation0.76872088
130MP0002751_abnormal_autonomic_nervous0.75994827
131* MP0002109_abnormal_limb_morphology0.75029250
132MP0008877_abnormal_DNA_methylation0.74412009

Predicted human phenotypes

RankGene SetZ-score
1Renal salt wasting (HP:0000127)4.76599261
2Abnormal sex determination (HP:0012244)3.87701578
3Sex reversal (HP:0012245)3.87701578
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68514068
5Short 4th metacarpal (HP:0010044)3.68514068
6Abnormality of the 4th metacarpal (HP:0010012)3.19215409
7Sudden death (HP:0001699)3.07891667
8Renal duplication (HP:0000075)3.06475326
9Hyperaldosteronism (HP:0000859)2.91185863
10Selective tooth agenesis (HP:0001592)2.90830210
11Right ventricular cardiomyopathy (HP:0011663)2.79662075
12Enlarged penis (HP:0000040)2.75158031
13Ventricular tachycardia (HP:0004756)2.70213129
14Hepatoblastoma (HP:0002884)2.69351286
15Shallow orbits (HP:0000586)2.61633075
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53693739
17* Bilateral microphthalmos (HP:0007633)2.51296372
18Abnormality of the ischium (HP:0003174)2.49237894
19Esophageal atresia (HP:0002032)2.48008517
20Broad thumb (HP:0011304)2.47448437
21Chromsome breakage (HP:0040012)2.46295107
22* Choanal stenosis (HP:0000452)2.43436396
23Hypoplastic labia majora (HP:0000059)2.38337684
24Vitreoretinal degeneration (HP:0000655)2.33894758
25Partial duplication of thumb phalanx (HP:0009944)2.32414047
26Broad toe (HP:0001837)2.31202354
27Colon cancer (HP:0003003)2.29381292
28Partial agenesis of the corpus callosum (HP:0001338)2.24398952
29Testicular neoplasm (HP:0010788)2.22524906
30Germ cell neoplasia (HP:0100728)2.21112541
31Breast carcinoma (HP:0003002)2.20547560
32Short middle phalanx of the 5th finger (HP:0004220)2.18743086
33Abnormality of the calf musculature (HP:0001430)2.18195425
34Supernumerary ribs (HP:0005815)2.16477137
35Abnormality of the labia majora (HP:0012881)2.14809801
36Skin pits (HP:0100276)2.14305284
37Preaxial foot polydactyly (HP:0001841)2.12906054
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11573954
39* Skull defect (HP:0001362)2.11266153
40Periauricular skin pits (HP:0100277)2.10020136
41Preauricular pit (HP:0004467)2.10020136
42Milia (HP:0001056)2.09489386
43* Bifid tongue (HP:0010297)2.08015628
44Anal stenosis (HP:0002025)2.07769371
45Subaortic stenosis (HP:0001682)2.05426808
46Abnormality of the left ventricular outflow tract (HP:0011103)2.05426808
47Increased nuchal translucency (HP:0010880)2.04954734
48* Myelomeningocele (HP:0002475)2.04873412
49Short 5th finger (HP:0009237)2.04302841
50Abnormal pancreas size (HP:0012094)2.04037548
51Abnormal number of incisors (HP:0011064)2.03029991
52Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02776385
53Duplication of thumb phalanx (HP:0009942)2.02668683
54Trigonocephaly (HP:0000243)2.00671998
55Atrial fibrillation (HP:0005110)2.00488478
56Rib fusion (HP:0000902)2.00092564
57Aplasia involving bones of the upper limbs (HP:0009823)1.99627080
58Aplasia of the phalanges of the hand (HP:0009802)1.99627080
59Aplasia involving bones of the extremities (HP:0009825)1.99627080
60Broad phalanges of the hand (HP:0009768)1.99134023
61Partial duplication of the phalanx of hand (HP:0009999)1.98599896
62* Cutaneous syndactyly (HP:0012725)1.98065683
63* Anophthalmia (HP:0000528)1.97025555
64Abnormality of the labia minora (HP:0012880)1.95808223
65Hypokalemic alkalosis (HP:0001949)1.95335703
66* Cutaneous finger syndactyly (HP:0010554)1.94916170
67* Midline defect of the nose (HP:0004122)1.93232488
68Triphalangeal thumb (HP:0001199)1.92399790
69Broad finger (HP:0001500)1.92366074
70Supernumerary bones of the axial skeleton (HP:0009144)1.92105086
71Vertebral clefting (HP:0008428)1.92060404
72Absent radius (HP:0003974)1.90363706
73Coronal craniosynostosis (HP:0004440)1.87040765
74Primary atrial arrhythmia (HP:0001692)1.86262070
75Asymmetry of the thorax (HP:0001555)1.84462506
76Gastrointestinal atresia (HP:0002589)1.84172722
77Exercise-induced muscle cramps (HP:0003710)1.83733739
78Broad metatarsal (HP:0001783)1.83607789
79Missing ribs (HP:0000921)1.83292178
80Limited hip movement (HP:0008800)1.82425685
81Pseudobulbar signs (HP:0002200)1.82183950
82Microglossia (HP:0000171)1.81861424
83Atrophic scars (HP:0001075)1.81809361
84Supraventricular arrhythmia (HP:0005115)1.81625292
85Long eyelashes (HP:0000527)1.81340424
86Gonadal dysgenesis (HP:0000133)1.80865902
87Skin tags (HP:0010609)1.80041290
88Proximal tubulopathy (HP:0000114)1.79349601
89Ovarian neoplasm (HP:0100615)1.78959605
90Supraventricular tachycardia (HP:0004755)1.78705801
91Hip contracture (HP:0003273)1.77200336
92Shawl scrotum (HP:0000049)1.76958402
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.76928017
94Ependymoma (HP:0002888)1.76413637
95Ankle contracture (HP:0006466)1.75478800
96Natal tooth (HP:0000695)1.75444515
97Absent forearm bone (HP:0003953)1.74625571
98Aplasia involving forearm bones (HP:0009822)1.74625571
99* Clitoromegaly (HP:0000057)1.73872808
100Calf muscle hypertrophy (HP:0008981)1.73816638
101Nephroblastoma (Wilms tumor) (HP:0002667)1.73771128
102Deviation of the thumb (HP:0009603)1.73710914
103Synostosis of carpal bones (HP:0005048)1.73438585
104Broad hallux (HP:0010055)1.73258185
105* Aplasia/Hypoplasia of the sternum (HP:0006714)1.73124930
106Preauricular skin tag (HP:0000384)1.73114853
107Lipoatrophy (HP:0100578)1.72851051
108Rectal prolapse (HP:0002035)1.72673950
109Medulloblastoma (HP:0002885)1.71601226
110Proximal placement of thumb (HP:0009623)1.71406556
111Vaginal fistula (HP:0004320)1.70496109
112Maternal diabetes (HP:0009800)1.70351732
113Embryonal renal neoplasm (HP:0011794)1.68789367
114Gastrointestinal carcinoma (HP:0002672)1.68297963
115Malignant gastrointestinal tract tumors (HP:0006749)1.68297963
116* Renal hypoplasia (HP:0000089)1.67842010
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.67503138
118Broad phalanx (HP:0006009)1.66902725
119* Hypospadias (HP:0000047)1.66498045
120Alacrima (HP:0000522)1.66124726
121* Atresia of the external auditory canal (HP:0000413)1.65919859
122Aplasia cutis congenita (HP:0001057)1.65344153
123Hypoplastic ischia (HP:0003175)1.65026982
124* Ectopic anus (HP:0004397)1.64927518
125Neoplasm of the adrenal cortex (HP:0100641)1.64831058
126Thyroid carcinoma (HP:0002890)1.64675901
127Meckel diverticulum (HP:0002245)1.64608558
128Broad long bones (HP:0005622)1.64456451
129Abnormality of the parietal bone (HP:0002696)1.62573729
130Abnormality of the antihelix (HP:0009738)1.62338115
131Bronchomalacia (HP:0002780)1.62244661
132Papillary thyroid carcinoma (HP:0002895)1.61704024
133* Tracheal stenosis (HP:0002777)1.61649325
134Hemangiomatosis (HP:0007461)1.61627893
135* Bicornuate uterus (HP:0000813)1.61527957
136Renovascular hypertension (HP:0100817)1.60917968
137Concave nail (HP:0001598)1.60711295
138* Abnormality of the pubic bones (HP:0003172)1.60568691
139Down-sloping shoulders (HP:0200021)1.59908513
140Oligodactyly (HP:0012165)1.59751745
141Hyperacusis (HP:0010780)1.59271310
142Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.59162263
143* Abnormal lung lobation (HP:0002101)1.58981331
144Septo-optic dysplasia (HP:0100842)1.58376062
145Ankyloglossia (HP:0010296)1.58365937
146Diastasis recti (HP:0001540)1.58179536
147Sprengel anomaly (HP:0000912)1.58088263
148* Absent eyebrow (HP:0002223)1.57711648
149Curly hair (HP:0002212)1.57550339
150* Morphological abnormality of the middle ear (HP:0008609)1.57146340
151Abnormality of the ileum (HP:0001549)1.56608585
152Short hallux (HP:0010109)1.56363901
153Muscle fiber splitting (HP:0003555)1.56179097
154Intestinal polyp (HP:0005266)1.56065207
155Lymphangioma (HP:0100764)1.55736950
156Embryonal neoplasm (HP:0002898)1.55592014
157High anterior hairline (HP:0009890)1.55228149
158Abnormality of the diencephalon (HP:0010662)1.55209584
159Renal dysplasia (HP:0000110)1.54915067
160Primary amenorrhea (HP:0000786)1.54808300
161Intestinal atresia (HP:0011100)1.53822078
162Visceral angiomatosis (HP:0100761)1.52422414
163Enlarged kidneys (HP:0000105)1.52067439
164Cystic hygroma (HP:0000476)1.51616090
165* Omphalocele (HP:0001539)1.51238447
166Male pseudohermaphroditism (HP:0000037)1.50864441
167Rectovaginal fistula (HP:0000143)1.49641947
168Rectal fistula (HP:0100590)1.49641947
169Aqueductal stenosis (HP:0002410)1.48750059
170Bifid scrotum (HP:0000048)1.48028001
171* Abnormality of the lacrimal duct (HP:0011481)1.47889437
172Stenosis of the external auditory canal (HP:0000402)1.47730772
173Hyperglycinuria (HP:0003108)1.47177680
174Labial hypoplasia (HP:0000066)1.46955398
175Arnold-Chiari malformation (HP:0002308)1.46568193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.28851221
2CDK122.88001207
3TTN2.69269526
4EPHB22.50882033
5MAP3K102.49748763
6PKN22.32207919
7STK38L2.31020804
8LMTK22.18513010
9PLK42.17081325
10CDC72.14677342
11OBSCN2.11831735
12TAF12.08064166
13LATS22.07648005
14EEF2K1.92777588
15TRIB31.90428595
16MKNK11.89400362
17PDGFRA1.69491487
18BRD41.58932040
19OXSR11.56469360
20NEK11.56434428
21WNK31.53907886
22DMPK1.53465666
23FGFR11.53007774
24RPS6KB21.49524453
25TNIK1.48022631
26STK391.48019874
27SCYL21.43311583
28ICK1.43131354
29CASK1.42903296
30DDR21.40052769
31MKNK21.36942771
32PASK1.36562500
33PRKD31.36452333
34TTK1.35437019
35STK31.34155247
36PNCK1.33879655
37PHKG21.33169279
38PHKG11.33169279
39FGFR21.31431029
40EPHA41.28615882
41MTOR1.26611243
42NME11.24658620
43NEK21.24002273
44TGFBR11.23147942
45PLK31.15029473
46CSNK1G11.13693870
47MET1.13371107
48VRK21.09922342
49NUAK11.07069198
50PTK61.06747118
51PAK41.04619878
52CDK61.03736355
53ERBB30.97809793
54BMPR1B0.97105245
55SRPK10.95997992
56MELK0.95676931
57CAMK1D0.93961809
58CDC42BPA0.93328200
59CDK40.92192387
60AKT20.92039080
61KSR10.91266867
62PAK20.90860761
63CAMK1G0.90417226
64FGFR40.89744250
65TSSK60.87686579
66STK40.87598004
67ERBB20.86372351
68ALK0.86252920
69RIPK10.85757692
70MAP3K120.85578941
71AURKB0.85427669
72NEK60.84982864
73CHEK10.84359535
74ILK0.81683260
75RPS6KB10.80550838
76MYLK0.78457294
77MAP3K40.78009574
78CDK70.77958244
79BCR0.77899172
80PBK0.77159582
81CHEK20.76054521
82SIK10.73587024
83CSNK1G20.73533040
84SMG10.72527149
85PAK30.72423986
86BUB10.71535508
87ATM0.69746274
88PLK10.69339262
89PTK20.68496514
90ERBB40.67914257
91CSNK1G30.67791449
92BRSK20.67645699
93FRK0.67584680
94TRIM280.66784156
95GRK10.66693870
96AKT30.66600826
97PDK30.65097301
98PDK40.65097301
99CSNK1D0.63962333
100ATR0.63517838
101WNK40.63150855
102EPHA20.62901387
103ROCK10.60991809
104DYRK1B0.60560044
105CDK20.59901971
106STK240.58350304
107EIF2AK20.58295159
108CDK10.57591992
109YES10.57512221
110MAP2K20.57426828
111NTRK20.55880835
112PDGFRB0.55698146
113MUSK0.55063328
114RET0.54628738
115FER0.54340109
116WNK10.54258702
117MAP3K80.54151145
118PRKCI0.53186330
119CSNK1E0.52346937
120ZAK0.52022983
121WEE10.51460626
122VRK10.50988174
123CHUK0.50087422
124RPS6KA40.49869203
125TYRO30.49373900
126EIF2AK30.48325896
127SGK20.48175443
128TIE10.48086889
129PRKDC0.48072204
130ACVR1B0.47692515
131PIK3CA0.47333846
132AKT10.46750255
133RPS6KA10.44731802
134RPS6KA20.42194119
135CAMK40.39854783
136RPS6KC10.38812433
137RPS6KL10.38812433
138DYRK30.38776025
139FLT30.38198346
140CSNK1A1L0.37299900
141BMX0.37230916
142NLK0.36824045
143MARK30.35522463

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.93853032
2Steroid biosynthesis_Homo sapiens_hsa001003.07982265
3Hedgehog signaling pathway_Homo sapiens_hsa043403.07023652
4Hippo signaling pathway_Homo sapiens_hsa043903.00805087
5Adherens junction_Homo sapiens_hsa045202.54446924
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40305816
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.39824539
8Ovarian steroidogenesis_Homo sapiens_hsa049132.32974439
9Dilated cardiomyopathy_Homo sapiens_hsa054142.31355935
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18007766
11Notch signaling pathway_Homo sapiens_hsa043302.11936760
12Tight junction_Homo sapiens_hsa045302.11493465
13Cell cycle_Homo sapiens_hsa041101.92891129
14Lysine degradation_Homo sapiens_hsa003101.92699670
15ECM-receptor interaction_Homo sapiens_hsa045121.88607032
16Vitamin digestion and absorption_Homo sapiens_hsa049771.86068026
17TGF-beta signaling pathway_Homo sapiens_hsa043501.85521547
18mRNA surveillance pathway_Homo sapiens_hsa030151.82567167
19Wnt signaling pathway_Homo sapiens_hsa043101.81504063
20Spliceosome_Homo sapiens_hsa030401.79742147
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.78743599
22MicroRNAs in cancer_Homo sapiens_hsa052061.78279008
23Selenocompound metabolism_Homo sapiens_hsa004501.76824014
24RNA transport_Homo sapiens_hsa030131.74157392
25Viral myocarditis_Homo sapiens_hsa054161.72822000
26Melanogenesis_Homo sapiens_hsa049161.71459961
27Proteoglycans in cancer_Homo sapiens_hsa052051.71129795
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64728029
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63688053
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60425057
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54347893
32Small cell lung cancer_Homo sapiens_hsa052221.52542870
33Focal adhesion_Homo sapiens_hsa045101.50481249
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42746172
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40667027
36Thyroid cancer_Homo sapiens_hsa052161.37181342
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35882066
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35118687
39Mismatch repair_Homo sapiens_hsa034301.34555737
40Endometrial cancer_Homo sapiens_hsa052131.31517330
41Cardiac muscle contraction_Homo sapiens_hsa042601.31166886
42Pathways in cancer_Homo sapiens_hsa052001.28648234
43Protein digestion and absorption_Homo sapiens_hsa049741.25694824
44Axon guidance_Homo sapiens_hsa043601.25539348
45Bladder cancer_Homo sapiens_hsa052191.24655473
46Oocyte meiosis_Homo sapiens_hsa041141.20280047
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.19782154
48HTLV-I infection_Homo sapiens_hsa051661.17027451
49Dorso-ventral axis formation_Homo sapiens_hsa043201.10804476
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07183349
51Colorectal cancer_Homo sapiens_hsa052101.06618876
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04258531
53Pyruvate metabolism_Homo sapiens_hsa006201.04140926
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96770221
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96395144
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.96371626
57Melanoma_Homo sapiens_hsa052180.94244619
58DNA replication_Homo sapiens_hsa030300.93990997
59Prostate cancer_Homo sapiens_hsa052150.93862831
60One carbon pool by folate_Homo sapiens_hsa006700.90705465
61RNA degradation_Homo sapiens_hsa030180.89267071
62Chronic myeloid leukemia_Homo sapiens_hsa052200.88614812
63mTOR signaling pathway_Homo sapiens_hsa041500.87194652
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86655515
65Glucagon signaling pathway_Homo sapiens_hsa049220.83864774
66Base excision repair_Homo sapiens_hsa034100.81770578
67Rap1 signaling pathway_Homo sapiens_hsa040150.81205056
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79767820
69Systemic lupus erythematosus_Homo sapiens_hsa053220.79696324
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79401430
71Insulin resistance_Homo sapiens_hsa049310.79244578
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76961768
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76936461
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76741028
75Amoebiasis_Homo sapiens_hsa051460.75757512
76Ribosome_Homo sapiens_hsa030100.75524420
77Insulin signaling pathway_Homo sapiens_hsa049100.72944878
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72074769
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71745458
80Viral carcinogenesis_Homo sapiens_hsa052030.70402222
81Renal cell carcinoma_Homo sapiens_hsa052110.69599266
82p53 signaling pathway_Homo sapiens_hsa041150.68352053
83Alcoholism_Homo sapiens_hsa050340.67896747
84Bile secretion_Homo sapiens_hsa049760.66954739
85Nucleotide excision repair_Homo sapiens_hsa034200.66469915
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65372371
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64875974
88Fatty acid biosynthesis_Homo sapiens_hsa000610.64619923
89Gap junction_Homo sapiens_hsa045400.63457484
90Estrogen signaling pathway_Homo sapiens_hsa049150.63200463
91Biosynthesis of amino acids_Homo sapiens_hsa012300.62974758
92Choline metabolism in cancer_Homo sapiens_hsa052310.62161492
93Non-small cell lung cancer_Homo sapiens_hsa052230.61803616
94Carbon metabolism_Homo sapiens_hsa012000.61698395
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61155551
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61111073
97Glioma_Homo sapiens_hsa052140.61108762
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60111574
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60091777
100AMPK signaling pathway_Homo sapiens_hsa041520.59303770
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59056846
102Homologous recombination_Homo sapiens_hsa034400.57615419
103Nitrogen metabolism_Homo sapiens_hsa009100.57578503
104HIF-1 signaling pathway_Homo sapiens_hsa040660.57529596
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.54836399
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54747985
107Fanconi anemia pathway_Homo sapiens_hsa034600.54212212
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52794531
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52201422
110beta-Alanine metabolism_Homo sapiens_hsa004100.50776557
111Propanoate metabolism_Homo sapiens_hsa006400.48434185
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47905778
113FoxO signaling pathway_Homo sapiens_hsa040680.47169817
114Butanoate metabolism_Homo sapiens_hsa006500.46924601
115Prolactin signaling pathway_Homo sapiens_hsa049170.44134967
116Histidine metabolism_Homo sapiens_hsa003400.41908712
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41695489
118Fatty acid metabolism_Homo sapiens_hsa012120.41168441
119Tryptophan metabolism_Homo sapiens_hsa003800.40782319
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.39307027
121Basal transcription factors_Homo sapiens_hsa030220.38787510
122ErbB signaling pathway_Homo sapiens_hsa040120.38771332
123Long-term depression_Homo sapiens_hsa047300.38475588
124Thyroid hormone synthesis_Homo sapiens_hsa049180.38411076
125Arginine and proline metabolism_Homo sapiens_hsa003300.37527378
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36335610
127Pancreatic cancer_Homo sapiens_hsa052120.35976473
128Fatty acid degradation_Homo sapiens_hsa000710.33108378
129cAMP signaling pathway_Homo sapiens_hsa040240.30572821
130Non-homologous end-joining_Homo sapiens_hsa034500.28933977
131Type II diabetes mellitus_Homo sapiens_hsa049300.28511760

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