FRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)9.25425417
2skeletal muscle adaptation (GO:0043501)8.06761019
3striated muscle atrophy (GO:0014891)7.83236099
4muscle atrophy (GO:0014889)7.39723812
5negative regulation of muscle hypertrophy (GO:0014741)6.99303523
6skeletal muscle tissue regeneration (GO:0043403)6.72750342
7actin-myosin filament sliding (GO:0033275)6.39010837
8muscle filament sliding (GO:0030049)6.39010837
9protein K6-linked ubiquitination (GO:0085020)6.21642193
10regulation of skeletal muscle contraction (GO:0014819)6.07414500
11response to muscle activity (GO:0014850)5.79457431
12negative regulation of skeletal muscle tissue development (GO:0048642)5.52790078
13ribosomal small subunit assembly (GO:0000028)5.17261635
14actin-mediated cell contraction (GO:0070252)5.16674676
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15844648
16positive regulation of histone H3-K4 methylation (GO:0051571)5.01530216
17ATP synthesis coupled proton transport (GO:0015986)4.51903071
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.51903071
19cellular response to dexamethasone stimulus (GO:0071549)4.48274092
20response to activity (GO:0014823)4.44236297
21regulation of centriole replication (GO:0046599)4.38379512
22cullin deneddylation (GO:0010388)4.12129617
23response to dexamethasone (GO:0071548)4.10255290
24DNA deamination (GO:0045006)4.05938251
25maturation of SSU-rRNA (GO:0030490)4.02983004
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96096678
27protein neddylation (GO:0045116)3.87061439
28ribosomal small subunit biogenesis (GO:0042274)3.82386767
29protein deneddylation (GO:0000338)3.76219441
30proteasome assembly (GO:0043248)3.72375449
31chaperone-mediated protein transport (GO:0072321)3.71728970
32respiratory electron transport chain (GO:0022904)3.69733296
33regulation of meiosis I (GO:0060631)3.69059001
34telomere maintenance via semi-conservative replication (GO:0032201)3.65553855
35electron transport chain (GO:0022900)3.60022810
36viral transcription (GO:0019083)3.59156583
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.57478227
38regulation of DNA methylation (GO:0044030)3.56544930
39protein complex biogenesis (GO:0070271)3.53453355
40translational termination (GO:0006415)3.52219509
41telomere maintenance via recombination (GO:0000722)3.51813895
42postreplication repair (GO:0006301)3.49826366
43regulation of histone H3-K9 methylation (GO:0051570)3.46732226
44protein-cofactor linkage (GO:0018065)3.44039399
45DNA strand elongation involved in DNA replication (GO:0006271)3.43239778
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.36015895
47NADH dehydrogenase complex assembly (GO:0010257)3.36015895
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36015895
49DNA strand elongation (GO:0022616)3.35952119
50mitochondrial respiratory chain complex assembly (GO:0033108)3.32907814
51ribosomal large subunit biogenesis (GO:0042273)3.29752716
52termination of RNA polymerase III transcription (GO:0006386)3.27497745
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.27497745
54CENP-A containing nucleosome assembly (GO:0034080)3.27497139
55actin filament-based movement (GO:0030048)3.23249446
56kinetochore organization (GO:0051383)3.19991080
57DNA replication checkpoint (GO:0000076)3.17990213
58positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.17510215
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17385728
60protein trimerization (GO:0070206)3.15716601
61mitotic recombination (GO:0006312)3.15364912
62striated muscle adaptation (GO:0014888)3.13891484
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12987655
64cotranslational protein targeting to membrane (GO:0006613)3.12430068
65chromatin remodeling at centromere (GO:0031055)3.10580684
66kinetochore assembly (GO:0051382)3.09464851
67protein targeting to ER (GO:0045047)3.06937659
68DNA replication initiation (GO:0006270)3.05802786
69DNA double-strand break processing (GO:0000729)3.04126836
70translational elongation (GO:0006414)3.02621038
71ribonucleoprotein complex biogenesis (GO:0022613)3.02118588
72telomere maintenance via telomere lengthening (GO:0010833)2.99491229
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98522717
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98228367
75protein polyglutamylation (GO:0018095)2.97801320
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96360577
777-methylguanosine mRNA capping (GO:0006370)2.95721267
787-methylguanosine RNA capping (GO:0009452)2.95196163
79RNA capping (GO:0036260)2.95196163
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94472789
81protein localization to endoplasmic reticulum (GO:0070972)2.94040764
82transcription-coupled nucleotide-excision repair (GO:0006283)2.91409707
83dosage compensation (GO:0007549)2.91390724
84negative regulation of organelle assembly (GO:1902116)2.90958063
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90444085
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90415640
87antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89883177
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89713888
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89713888
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89713888
91nucleotide-excision repair, DNA gap filling (GO:0006297)2.88218452
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87966998
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87677763
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87677763
95meiotic chromosome segregation (GO:0045132)2.87020777
96translational initiation (GO:0006413)2.86159962
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86034677
98regulation of mitotic spindle checkpoint (GO:1903504)2.86034677
99regulation of muscle hypertrophy (GO:0014743)2.83110824
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82463001
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82463001
102termination of RNA polymerase I transcription (GO:0006363)2.82143091
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81439474
104negative regulation of ligase activity (GO:0051352)2.81439474
105viral life cycle (GO:0019058)2.80885659
106* rRNA processing (GO:0006364)2.80225096
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78164159
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.78164159
109regulation of mitochondrial translation (GO:0070129)2.77714588
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.76962799
111tissue regeneration (GO:0042246)2.76957398
112platelet dense granule organization (GO:0060155)2.76687156
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76659192
114cellular protein complex disassembly (GO:0043624)2.76605396
115formation of translation preinitiation complex (GO:0001731)2.75825240
116rRNA modification (GO:0000154)2.75485415
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75066986
118transcription elongation from RNA polymerase I promoter (GO:0006362)2.75008678
119DNA replication-independent nucleosome assembly (GO:0006336)2.74853758
120DNA replication-independent nucleosome organization (GO:0034724)2.74853758
121skeletal muscle contraction (GO:0003009)2.74244147
122rRNA methylation (GO:0031167)2.72716692
123* rRNA metabolic process (GO:0016072)2.72286150
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71256112
125ATP biosynthetic process (GO:0006754)2.70979362
126positive regulation of histone methylation (GO:0031062)2.70905150
127cellular response to glucocorticoid stimulus (GO:0071385)2.70649357
128negative regulation of protein acetylation (GO:1901984)2.70242595
129negative regulation of histone acetylation (GO:0035067)2.70027008
130regulation of gene expression by genetic imprinting (GO:0006349)2.68821438
131response to testosterone (GO:0033574)2.68713848
132muscle adaptation (GO:0043500)2.68576104
133organelle disassembly (GO:1903008)2.68357492
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68288775
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.67734218
136DNA ligation (GO:0006266)2.64260472
137viral mRNA export from host cell nucleus (GO:0046784)2.64003702
138maturation of 5.8S rRNA (GO:0000460)2.63928172
139transcription from RNA polymerase I promoter (GO:0006360)2.63772041
140mitotic metaphase plate congression (GO:0007080)2.63622791
141protein K11-linked ubiquitination (GO:0070979)2.62893870
142translation (GO:0006412)2.62860115
143water-soluble vitamin biosynthetic process (GO:0042364)2.62201235
144ribosome biogenesis (GO:0042254)2.60298757
145histone mRNA metabolic process (GO:0008334)2.59955069
146myotube cell development (GO:0014904)2.59823615
147negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59505260
148negative regulation of peptidyl-lysine acetylation (GO:2000757)2.59317727
149negative regulation of fatty acid biosynthetic process (GO:0045717)2.58370479
150resolution of meiotic recombination intermediates (GO:0000712)2.57928549
151regulation of cellular amino acid metabolic process (GO:0006521)2.57916217
152spliceosomal snRNP assembly (GO:0000387)2.57508256
153telomere organization (GO:0032200)2.57481362
154cellular ketone body metabolic process (GO:0046950)2.57473086
155regulation of relaxation of muscle (GO:1901077)2.57411939
156telomere maintenance (GO:0000723)2.57157189
157pseudouridine synthesis (GO:0001522)2.56904627
158attachment of spindle microtubules to kinetochore (GO:0008608)2.54956007
159DNA catabolic process, exonucleolytic (GO:0000738)2.53284106
160mismatch repair (GO:0006298)2.52242836
161maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51866005
162DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.51572730
163positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.49762807
164cellular component biogenesis (GO:0044085)2.49279756
165spliceosomal complex assembly (GO:0000245)2.47708069
166histone exchange (GO:0043486)2.47032266
167intra-S DNA damage checkpoint (GO:0031573)2.46372227
168regulation of double-strand break repair via homologous recombination (GO:0010569)2.45948695
169establishment of integrated proviral latency (GO:0075713)2.45639310
170positive regulation of ligase activity (GO:0051351)2.43199675
171nucleotide-excision repair (GO:0006289)2.42373923
172response to interferon-beta (GO:0035456)2.41940489
173cell cycle G1/S phase transition (GO:0044843)2.40250885
174G1/S transition of mitotic cell cycle (GO:0000082)2.40250885
175protein complex disassembly (GO:0043241)2.40170793
176metaphase plate congression (GO:0051310)2.40122081
177transcription initiation from RNA polymerase I promoter (GO:0006361)2.38331357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23043967
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84762705
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.58607825
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40811783
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.32434392
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10476649
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09673111
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09227288
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09040401
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08813450
11* VDR_22108803_ChIP-Seq_LS180_Human2.84315813
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81870215
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.66155989
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62770942
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62476095
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59315546
17* VDR_23849224_ChIP-Seq_CD4+_Human2.58205486
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50075123
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49965384
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.46615945
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45122199
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43320313
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43026794
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42307964
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39393456
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.38243806
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35905883
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28964530
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28339860
30ZNF274_21170338_ChIP-Seq_K562_Hela2.26108746
31ELK1_19687146_ChIP-ChIP_HELA_Human2.24119586
32IRF8_22096565_ChIP-ChIP_GC-B_Human2.22227831
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.20045842
34IRF8_21731497_ChIP-ChIP_J774_Mouse2.19219252
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17684773
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.15989312
37* FOXP3_21729870_ChIP-Seq_TREG_Human2.14539311
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13850216
39HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08850669
40MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08637878
41* FUS_26573619_Chip-Seq_HEK293_Human2.06767113
42* SRF_21415370_ChIP-Seq_HL-1_Mouse2.02251534
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99428663
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93998418
45EWS_26573619_Chip-Seq_HEK293_Human1.90545236
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.89238326
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88568173
48XRN2_22483619_ChIP-Seq_HELA_Human1.86497566
49* DCP1A_22483619_ChIP-Seq_HELA_Human1.85973449
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84672351
51* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81144805
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80724692
53* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80492128
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.79483568
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77826549
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77222202
57* TAF15_26573619_Chip-Seq_HEK293_Human1.74484795
58* TTF2_22483619_ChIP-Seq_HELA_Human1.71820694
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71332413
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71259227
61EZH2_22144423_ChIP-Seq_EOC_Human1.70779887
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.68892355
63SPI1_23547873_ChIP-Seq_NB4_Human1.67460148
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66505158
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61646211
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61571108
67GABP_19822575_ChIP-Seq_HepG2_Human1.61533743
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61371537
69TP53_22573176_ChIP-Seq_HFKS_Human1.61307739
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.58909017
71IGF1R_20145208_ChIP-Seq_DFB_Human1.55013291
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54620825
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53992691
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49806999
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48536979
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46485038
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43377309
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41604727
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40827449
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37859173
81GBX2_23144817_ChIP-Seq_PC3_Human1.36200514
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.34478858
83* P300_19829295_ChIP-Seq_ESCs_Human1.29621412
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28413928
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26506571
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26404325
87CIITA_25753668_ChIP-Seq_RAJI_Human1.25978746
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23054026
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22800329
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22238316
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21706409
92* ER_23166858_ChIP-Seq_MCF-7_Human1.21126847
93* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20200373
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20171757
95MYC_18940864_ChIP-ChIP_HL60_Human1.19461715
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19303798
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17279325
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.17119529
99* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15861795
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15643668
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14307181
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13866541
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12028254
104CBP_20019798_ChIP-Seq_JUKART_Human1.12028254
105IRF1_19129219_ChIP-ChIP_H3396_Human1.11461163
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10761414
107SCL_19346495_ChIP-Seq_HPC-7_Human1.10413076
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09053922
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.08136453
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07382154
111SALL4_22934838_ChIP-ChIP_CD34+_Human1.07095511
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06836534
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05013798
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04747108
115MYB_26560356_Chip-Seq_TH2_Human1.04205115
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04188920
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02943383
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.01474075
119CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98607589
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97898720
121SMAD4_21799915_ChIP-Seq_A2780_Human0.97601656
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96481221
123SOX2_19829295_ChIP-Seq_ESCs_Human0.95736877
124NANOG_19829295_ChIP-Seq_ESCs_Human0.95736877
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.95178956
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.93803096
127* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91742101
128AR_20517297_ChIP-Seq_VCAP_Human0.91427242
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91092456
130KDM5A_27292631_Chip-Seq_BREAST_Human0.90896266
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90174260
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89951585
133MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89897710
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89292734
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88936387
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87651487
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87547238
138AR_21909140_ChIP-Seq_LNCAP_Human0.87384556
139MYB_26560356_Chip-Seq_TH1_Human0.86786202
140P300_18555785_Chip-Seq_ESCs_Mouse0.86725742
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86390492
142P53_22387025_ChIP-Seq_ESCs_Mouse0.85406827
143TFEB_21752829_ChIP-Seq_HELA_Human0.84265045
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83476010
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83416124
146* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82355663
147IRF8_27001747_Chip-Seq_BMDM_Mouse0.82314362
148* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82190866
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80096705
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79381699
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78351350
152SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77417139
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.76910577
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76571768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.79738129
2MP0000747_muscle_weakness4.05254886
3MP0003693_abnormal_embryo_hatching3.65602963
4MP0008058_abnormal_DNA_repair3.28819605
5MP0001835_abnormal_antigen_presentation3.16817498
6MP0010094_abnormal_chromosome_stability3.10155795
7MP0002269_muscular_atrophy3.03957819
8MP0008057_abnormal_DNA_replication2.98504322
9MP0004036_abnormal_muscle_relaxation2.73285192
10MP0005671_abnormal_response_to2.70815623
11MP0002089_abnormal_postnatal_growth/wei2.65222207
12MP0000749_muscle_degeneration2.61393177
13MP0003077_abnormal_cell_cycle2.49443287
14MP0003111_abnormal_nucleus_morphology2.49391770
15MP0003806_abnormal_nucleotide_metabolis2.47718909
16MP0009785_altered_susceptibility_to2.45743134
17MP0002396_abnormal_hematopoietic_system2.44201623
18MP0003763_abnormal_thymus_physiology2.34833148
19MP0002148_abnormal_hypersensitivity_rea2.33110903
20MP0004957_abnormal_blastocyst_morpholog2.31243765
21MP0008007_abnormal_cellular_replicative2.14989932
22MP0003786_premature_aging2.13770878
23MP0000759_abnormal_skeletal_muscle2.13266337
24MP0000685_abnormal_immune_system2.12880797
25MP0001800_abnormal_humoral_immune2.11746604
26MP0002102_abnormal_ear_morphology2.08385930
27MP0006292_abnormal_olfactory_placode2.04527679
28MP0009333_abnormal_splenocyte_physiolog2.02377883
29MP0002837_dystrophic_cardiac_calcinosis1.97563024
30MP0002106_abnormal_muscle_physiology1.96021247
31MP0002452_abnormal_antigen_presenting1.94869071
32MP0005000_abnormal_immune_tolerance1.92743213
33MP0008877_abnormal_DNA_methylation1.90774407
34MP0002736_abnormal_nociception_after1.88925021
35MP0002420_abnormal_adaptive_immunity1.88907802
36MP0001819_abnormal_immune_cell1.87559189
37MP0003950_abnormal_plasma_membrane1.87088523
38MP0002723_abnormal_immune_serum1.86718838
39MP0003136_yellow_coat_color1.86692149
40MP0002398_abnormal_bone_marrow1.86292530
41MP0006072_abnormal_retinal_apoptosis1.85960383
42MP0005025_abnormal_response_to1.85895754
43MP0000490_abnormal_crypts_of1.84642352
44MP0004142_abnormal_muscle_tone1.80751078
45MP0002132_abnormal_respiratory_system1.80458174
46MP0002108_abnormal_muscle_morphology1.80136911
47MP0003436_decreased_susceptibility_to1.74880984
48MP0005083_abnormal_biliary_tract1.72776568
49MP0005620_abnormal_muscle_contractility1.68901090
50MP0001790_abnormal_immune_system1.67169850
51MP0005387_immune_system_phenotype1.67169850
52MP0002419_abnormal_innate_immunity1.66173545
53MP0008932_abnormal_embryonic_tissue1.63589213
54MP0003646_muscle_fatigue1.63529046
55MP0000716_abnormal_immune_system1.63332384
56MP0005075_abnormal_melanosome_morpholog1.61947160
57MP0006036_abnormal_mitochondrial_physio1.60571225
58MP0008260_abnormal_autophagy1.60302190
59MP0000689_abnormal_spleen_morphology1.55516531
60MP0002722_abnormal_immune_system1.54622698
61MP0000569_abnormal_digit_pigmentation1.54501177
62MP0003959_abnormal_lean_body1.51225163
63MP0005174_abnormal_tail_pigmentation1.50887792
64MP0001968_abnormal_touch/_nociception1.50153236
65MP0005369_muscle_phenotype1.49320695
66MP0002405_respiratory_system_inflammati1.49271992
67MP0000015_abnormal_ear_pigmentation1.45983528
68MP0002429_abnormal_blood_cell1.45512326
69MP0002277_abnormal_respiratory_mucosa1.44458743
70MP0001853_heart_inflammation1.43427083
71MP0004087_abnormal_muscle_fiber1.39806332
72MP0006035_abnormal_mitochondrial_morpho1.38794474
73MP0001986_abnormal_taste_sensitivity1.37809106
74MP0001188_hyperpigmentation1.37213156
75MP0000703_abnormal_thymus_morphology1.37086485
76MP0002095_abnormal_skin_pigmentation1.37075022
77MP0004808_abnormal_hematopoietic_stem1.35487687
78MP0003724_increased_susceptibility_to1.34526681
79MP0004215_abnormal_myocardial_fiber1.33882596
80MP0003880_abnormal_central_pattern1.33116729
81MP0003787_abnormal_imprinting1.32396981
82MP0010155_abnormal_intestine_physiology1.32330004
83MP0000631_abnormal_neuroendocrine_gland1.31365709
84MP0008995_early_reproductive_senescence1.30881899
85MP0001529_abnormal_vocalization1.30477503
86MP0009379_abnormal_foot_pigmentation1.29097447
87MP0003186_abnormal_redox_activity1.28911840
88MP0003718_maternal_effect1.28070232
89MP0000566_synostosis1.27004121
90MP0002006_tumorigenesis1.26879180
91MP0000427_abnormal_hair_cycle1.26806388
92MP0005084_abnormal_gallbladder_morpholo1.24290005
93MP0003937_abnormal_limbs/digits/tail_de1.23523928
94MP0000465_gastrointestinal_hemorrhage1.19347028
95MP0002019_abnormal_tumor_incidence1.18891955
96MP0004043_abnormal_pH_regulation1.18073217
97MP0001873_stomach_inflammation1.17715967
98MP0000372_irregular_coat_pigmentation1.16442140
99MP0004381_abnormal_hair_follicle1.16210062
100MP0006082_CNS_inflammation1.15907514
101MP0005464_abnormal_platelet_physiology1.14724695
102MP0001845_abnormal_inflammatory_respons1.06025051
103MP0000313_abnormal_cell_death1.05074501
104MP0002166_altered_tumor_susceptibility1.04277600
105MP0005551_abnormal_eye_electrophysiolog1.02202173
106MP0005253_abnormal_eye_physiology1.02044668
107MP0005397_hematopoietic_system_phenotyp1.01888268
108MP0001545_abnormal_hematopoietic_system1.01888268
109MP0000750_abnormal_muscle_regeneration1.01683157
110MP0002210_abnormal_sex_determination0.98789871
111MP0009697_abnormal_copulation0.97806759
112MP0000858_altered_metastatic_potential0.96813955
113MP0005645_abnormal_hypothalamus_physiol0.96387163
114MP0002163_abnormal_gland_morphology0.95225198
115MP0009250_abnormal_appendicular_skeleto0.93832424
116MP0003866_abnormal_defecation0.93800951
117MP0005646_abnormal_pituitary_gland0.92898577
118MP0004885_abnormal_endolymph0.92111005
119MP0003941_abnormal_skin_development0.91797214
120MP0001119_abnormal_female_reproductive0.90133612
121MP0002139_abnormal_hepatobiliary_system0.90088777
122MP0000350_abnormal_cell_proliferation0.88523678
123MP0003121_genomic_imprinting0.86492927
124MP0002938_white_spotting0.86109747
125MP0001905_abnormal_dopamine_level0.85630805
126MP0005409_darkened_coat_color0.84108727
127MP0004270_analgesia0.83706312
128MP0003448_altered_tumor_morphology0.82480734
129MP0001764_abnormal_homeostasis0.80003453
130MP0001486_abnormal_startle_reflex0.77989712
131MP0001984_abnormal_olfaction0.77881857
132MP0009745_abnormal_behavioral_response0.77291252
133MP0002933_joint_inflammation0.77286237
134MP0002638_abnormal_pupillary_reflex0.76864353
135MP0001293_anophthalmia0.76507797
136MP0004134_abnormal_chest_morphology0.75675058
137MP0003698_abnormal_male_reproductive0.74991060
138MP0000049_abnormal_middle_ear0.73060158
139MP0003315_abnormal_perineum_morphology0.72655446
140MP0001145_abnormal_male_reproductive0.72393380
141MP0002272_abnormal_nervous_system0.72382117
142MP0005310_abnormal_salivary_gland0.72367277
143MP0005389_reproductive_system_phenotype0.71837344
144MP0008469_abnormal_protein_level0.71408671
145MP0005408_hypopigmentation0.69787043
146MP0003195_calcinosis0.69499906
147MP0001929_abnormal_gametogenesis0.69426718
148MP0008789_abnormal_olfactory_epithelium0.68950983
149MP0010307_abnormal_tumor_latency0.67618573
150MP0003890_abnormal_embryonic-extraembry0.67397551
151MP0002160_abnormal_reproductive_system0.67231538
152MP0001919_abnormal_reproductive_system0.66604163
153MP0001243_abnormal_dermal_layer0.66460147
154MP0005636_abnormal_mineral_homeostasis0.65953092
155MP0002009_preneoplasia0.65406249
156MP0000653_abnormal_sex_gland0.64476536
157MP0005266_abnormal_metabolism0.63745850
158MP0003567_abnormal_fetal_cardiomyocyte0.63574874
159MP0005379_endocrine/exocrine_gland_phen0.62276304
160MP0002067_abnormal_sensory_capabilities0.61454133
161MP0008872_abnormal_physiological_respon0.61429094
162MP0001186_pigmentation_phenotype0.59815860
163MP0004147_increased_porphyrin_level0.58615425
164MP0001533_abnormal_skeleton_physiology0.57414167
165MP0001730_embryonic_growth_arrest0.57109970
166MP0001542_abnormal_bone_strength0.56091335

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.17822402
2Distal arthrogryposis (HP:0005684)5.01951365
3Absent phalangeal crease (HP:0006109)4.59660025
4Acute necrotizing encephalopathy (HP:0006965)4.34326197
5Abnormal finger flexion creases (HP:0006143)4.24453825
6Reticulocytopenia (HP:0001896)4.07117874
7Muscle fiber inclusion bodies (HP:0100299)4.00391815
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.95408257
9Round ear (HP:0100830)3.93261549
10Progressive macrocephaly (HP:0004481)3.91659912
11Calcaneovalgus deformity (HP:0001848)3.89909050
12Abnormal mitochondria in muscle tissue (HP:0008316)3.89586095
13Exercise-induced myalgia (HP:0003738)3.89292918
14Acute encephalopathy (HP:0006846)3.77719056
15Mitochondrial inheritance (HP:0001427)3.71191320
16Chromsome breakage (HP:0040012)3.65063933
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61050123
18Deformed tarsal bones (HP:0008119)3.58461775
19Ulnar deviation of the wrist (HP:0003049)3.55200565
20Birth length less than 3rd percentile (HP:0003561)3.50661707
21Increased CSF lactate (HP:0002490)3.50512338
22Type I transferrin isoform profile (HP:0003642)3.17236908
23Hyperkalemia (HP:0002153)3.07908920
24Abnormality of cells of the erythroid lineage (HP:0012130)3.04934856
25Recurrent abscess formation (HP:0002722)3.03985054
26Hepatocellular necrosis (HP:0001404)2.94441838
27IgM deficiency (HP:0002850)2.91324385
28Abnormal number of erythroid precursors (HP:0012131)2.90871578
29Lipid accumulation in hepatocytes (HP:0006561)2.87835134
30Hepatic necrosis (HP:0002605)2.85964675
31Petechiae (HP:0000967)2.74400100
32Myositis (HP:0100614)2.74127046
33IgG deficiency (HP:0004315)2.69211075
34Abnormality of the preputium (HP:0100587)2.66803505
35Cerebral edema (HP:0002181)2.64692250
36Abnormality of DNA repair (HP:0003254)2.63913598
37Elevated erythrocyte sedimentation rate (HP:0003565)2.61987108
38Thrombocytosis (HP:0001894)2.61458645
39Meckel diverticulum (HP:0002245)2.61066122
40Aplastic anemia (HP:0001915)2.58889429
41Abnormality of chromosome stability (HP:0003220)2.57136406
42Renal Fanconi syndrome (HP:0001994)2.55844646
43Recurrent bacterial skin infections (HP:0005406)2.54231964
44Abnormality of the ileum (HP:0001549)2.51193691
45Retrobulbar optic neuritis (HP:0100654)2.48604735
46Optic neuritis (HP:0100653)2.48604735
47Severe combined immunodeficiency (HP:0004430)2.44804338
48Myotonia (HP:0002486)2.44457187
49Myoglobinuria (HP:0002913)2.44449011
50Exercise-induced muscle cramps (HP:0003710)2.43772017
51Pallor (HP:0000980)2.42612288
52Reduced antithrombin III activity (HP:0001976)2.41441373
53Type 2 muscle fiber atrophy (HP:0003554)2.40295990
54Recurrent pneumonia (HP:0006532)2.39395148
55Chronic obstructive pulmonary disease (HP:0006510)2.38588898
56Obstructive lung disease (HP:0006536)2.38588898
57Abnormality of B cell number (HP:0010975)2.35025710
58B lymphocytopenia (HP:0010976)2.35025710
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.33988318
603-Methylglutaconic aciduria (HP:0003535)2.33944154
61Exercise intolerance (HP:0003546)2.30455340
62Type 1 muscle fiber predominance (HP:0003803)2.27539367
63Lymphoma (HP:0002665)2.27322400
64Eczematoid dermatitis (HP:0000976)2.26129159
65Increased serum lactate (HP:0002151)2.25614401
66Abnormality of midbrain morphology (HP:0002418)2.25300149
67Molar tooth sign on MRI (HP:0002419)2.25300149
68Oligodactyly (hands) (HP:0001180)2.24452347
69Macrocytic anemia (HP:0001972)2.21907429
70Gonadotropin excess (HP:0000837)2.21580272
71Bone marrow hypocellularity (HP:0005528)2.21422359
72Agammaglobulinemia (HP:0004432)2.20974946
73Myelodysplasia (HP:0002863)2.20418625
74Abnormality of the prostate (HP:0008775)2.20130813
75Granulocytopenia (HP:0001913)2.19635227
76Meningitis (HP:0001287)2.19428060
77Exertional dyspnea (HP:0002875)2.18485360
78Breast hypoplasia (HP:0003187)2.17389419
79Lactic acidosis (HP:0003128)2.16992593
80Combined immunodeficiency (HP:0005387)2.16925349
81Volvulus (HP:0002580)2.15992530
82Clubbing of toes (HP:0100760)2.15694672
83Optic disc pallor (HP:0000543)2.15297854
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14499818
85Abnormal protein N-linked glycosylation (HP:0012347)2.14499818
86Abnormal protein glycosylation (HP:0012346)2.14499818
87Abnormal glycosylation (HP:0012345)2.14499818
88Respiratory failure (HP:0002878)2.13930125
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13641101
90Abnormality of alanine metabolism (HP:0010916)2.13641101
91Hyperalaninemia (HP:0003348)2.13641101
92Muscle fiber atrophy (HP:0100295)2.13514269
93Orchitis (HP:0100796)2.13224701
94Fibular aplasia (HP:0002990)2.12544838
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12152301
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12152301
97Thyroiditis (HP:0100646)2.11085055
98Methylmalonic acidemia (HP:0002912)2.10787267
99Patellar aplasia (HP:0006443)2.10424720
100Aplasia/Hypoplasia of the tongue (HP:0010295)2.09445158
101Absent thumb (HP:0009777)2.09232792
102Myopathic facies (HP:0002058)2.08825818
103Abnormality of eosinophils (HP:0001879)2.08498318
104Eosinophilia (HP:0001880)2.07138047
105Duplicated collecting system (HP:0000081)2.06525348
106Lymphopenia (HP:0001888)2.06289138
107Increased hepatocellular lipid droplets (HP:0006565)2.05884903
108Microglossia (HP:0000171)2.05206618
109Mediastinal lymphadenopathy (HP:0100721)2.04928067
110Abnormality of the renal collecting system (HP:0004742)2.04575431
111Nephronophthisis (HP:0000090)2.04452973
112Paralysis (HP:0003470)2.03399523
113Panhypogammaglobulinemia (HP:0003139)2.02684199
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.02658154
115Increased intramyocellular lipid droplets (HP:0012240)2.02536497
116Recurrent lower respiratory tract infections (HP:0002783)2.02515660
117Prostate neoplasm (HP:0100787)2.02442093
118Premature graying of hair (HP:0002216)2.01916325
119Poikiloderma (HP:0001029)2.01634833
120Abnormality of potassium homeostasis (HP:0011042)2.01552033
121Rough bone trabeculation (HP:0100670)2.00583845
122Recurrent bronchitis (HP:0002837)2.00527200
123Agnosia (HP:0010524)1.99924122
124Metabolic acidosis (HP:0001942)1.99377586
125Cleft eyelid (HP:0000625)1.98976758
126Abnormality of the labia minora (HP:0012880)1.98470074
127True hermaphroditism (HP:0010459)1.98402103
128Generalized aminoaciduria (HP:0002909)1.97620480
129Abnormality of T cells (HP:0002843)1.97591651
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96385441
131Aplasia/Hypoplasia of the patella (HP:0006498)1.95845492
132Recurrent fungal infections (HP:0002841)1.95411495
13311 pairs of ribs (HP:0000878)1.95024247
134Degeneration of anterior horn cells (HP:0002398)1.94574959
135Abnormality of the anterior horn cell (HP:0006802)1.94574959
136Stenosis of the external auditory canal (HP:0000402)1.94401693
137Duodenal stenosis (HP:0100867)1.93286075
138Small intestinal stenosis (HP:0012848)1.93286075
139Microvesicular hepatic steatosis (HP:0001414)1.92959097
140Decreased circulating renin level (HP:0003351)1.92065657
141Increased IgM level (HP:0003496)1.90119052
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90067901
143Neutropenia (HP:0001875)1.89409759
144Pancytopenia (HP:0001876)1.88888546
145Pancreatic cysts (HP:0001737)1.88565860
146Abnormality of T cell physiology (HP:0011840)1.87449360
147Vasculitis (HP:0002633)1.87176593
148Encephalitis (HP:0002383)1.86580969
149Chronic otitis media (HP:0000389)1.86105286
150Abnormality of T cell number (HP:0011839)1.85247603
151Leukocytosis (HP:0001974)1.84714893
152Congenital stationary night blindness (HP:0007642)1.84073706
153Methylmalonic aciduria (HP:0012120)1.84003108
154Recurrent viral infections (HP:0004429)1.83239646
155Medial flaring of the eyebrow (HP:0010747)1.82345204
156Triphalangeal thumb (HP:0001199)1.81996089
157Oral leukoplakia (HP:0002745)1.81951870
158Pancreatic fibrosis (HP:0100732)1.81470346
159Abnormality of the fovea (HP:0000493)1.80429504
160Increased serum pyruvate (HP:0003542)1.80427362
161Rhabdomyolysis (HP:0003201)1.80255632
162Posterior subcapsular cataract (HP:0007787)1.79675104
163Recurrent cutaneous fungal infections (HP:0011370)1.79089664
164Congenital, generalized hypertrichosis (HP:0004540)1.78550815
165Abnormality of renal resorption (HP:0011038)1.78455165
166Long clavicles (HP:0000890)1.75032627
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.74358436
168Hypoplasia of the fovea (HP:0007750)1.74358436
169Abnormality of macular pigmentation (HP:0008002)1.74358117
170Respiratory difficulties (HP:0002880)1.74159228
171Abnormal pupillary function (HP:0007686)1.73241980
172Colon cancer (HP:0003003)1.71191802
173Renal cortical cysts (HP:0000803)1.70843942
174Abnormality of urine glucose concentration (HP:0011016)1.67680569
175Glycosuria (HP:0003076)1.67680569
176X-linked dominant inheritance (HP:0001423)1.63898426
177Muscle stiffness (HP:0003552)1.63201328
178Hypoplastic iliac wings (HP:0002866)1.63102271
179Abnormality of the pons (HP:0007361)1.61399661
180Ovarian neoplasm (HP:0100615)1.61011852
181Abnormality of the renal medulla (HP:0100957)1.60774502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.28530211
2BUB12.99371862
3TAOK32.92772006
4SRPK12.72773616
5TIE12.70707173
6PHKG22.69971084
7PHKG12.69971084
8OBSCN2.67859514
9EIF2AK12.63012773
10TXK2.62726886
11NME22.46920650
12WEE12.41082538
13WNK42.36424528
14EIF2AK32.33048857
15IRAK42.23271844
16ACVR1B2.20850565
17MAPK132.14515136
18MKNK11.99882247
19VRK11.93883087
20VRK21.92529053
21MAP4K21.92317071
22PLK41.91227409
23MAP4K11.90525937
24MKNK21.90133016
25BLK1.77106464
26MAP3K141.74909717
27CDC71.71933557
28TEC1.71348078
29ZAK1.67496668
30KIT1.61065848
31EIF2AK21.59541034
32MST41.58335961
33PIM21.54382473
34PINK11.52938553
35CAMKK21.51992894
36TLK11.49796699
37WNK31.49022681
38PBK1.39682456
39BTK1.39097915
40FRK1.38603198
41IRAK31.33325432
42DYRK31.30133439
43PASK1.29106625
44IKBKB1.28072938
45CLK11.27403067
46BMPR1B1.27069000
47WNK11.26362210
48OXSR11.23741962
49SIK31.22719057
50CCNB11.20323347
51IKBKE1.19053175
52PLK11.17519429
53STK391.16133733
54BRSK21.15646089
55ATR1.13799978
56PIK3CA1.12467232
57PIK3CG1.11955709
58ZAP701.11839768
59NEK11.10950998
60CDK81.09942997
61NUAK11.09771388
62BCKDK1.06544796
63YES11.05721301
64JAK31.05195524
65CSNK1G11.03452749
66SYK1.03139830
67AURKB1.01540254
68TRIM281.00869711
69RPS6KB21.00599752
70MAP3K121.00243952
71STK41.00147610
72PIM10.99775554
73CDK70.99028945
74NEK20.98753016
75TSSK60.97801058
76TYK20.97691183
77LYN0.96480636
78TGFBR10.96401066
79ADRBK20.96199264
80NLK0.95306883
81TAF10.94133978
82TESK20.92702992
83IRAK10.89438905
84INSRR0.88784210
85MAP3K40.88299762
86TBK10.84315876
87TTK0.82203804
88STK240.80946006
89PLK30.80503739
90CSNK1G20.78421027
91CHEK20.77603622
92LCK0.77296012
93CSNK1G30.77015378
94DYRK20.76808151
95STK100.76524202
96NEK60.75488357
97RPS6KA50.73601600
98PDK20.70801315
99KDR0.70618861
100PLK20.70341736
101CASK0.69850226
102TYRO30.69660697
103LIMK10.67634997
104CSF1R0.67378038
105CHUK0.65868627
106RPS6KA40.64433899
107MAP2K30.63238383
108CSNK2A10.61733807
109CAMK2G0.61411466
110GRK70.60222660
111BMPR20.60127660
112TAOK20.59892932
113AURKA0.58613440
114CSNK1A1L0.56628589
115MUSK0.56218881
116TNIK0.54590772
117PRKG10.54312118
118BRSK10.52762818
119CDK30.50129561
120MAP2K70.50111367
121ERBB30.49181540
122ITK0.48760956
123GRK10.47311662
124MARK30.47229135
125MAP3K30.46637981
126CSNK2A20.45916962
127MINK10.45299570
128CHEK10.45249742
129ATM0.44777690
130BRAF0.44715964
131TRPM70.43665171
132CDK40.42541995
133RIPK40.42099635
134PRKACB0.41349894
135NME10.39993084
136BCR0.39958709
137STK30.38944916
138MAPKAPK20.36953870
139ILK0.36421801
140TNK20.36189880
141BRD40.35602256
142PRKCG0.35229682
143CAMK1D0.34877521
144PRKCE0.32745426
145PRKACA0.32057069
146CSNK1E0.31773711
147PRKCQ0.31700075
148CSNK1A10.31635845

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.69166440
2DNA replication_Homo sapiens_hsa030303.58436518
3Proteasome_Homo sapiens_hsa030503.53991596
4RNA polymerase_Homo sapiens_hsa030203.26148097
5Mismatch repair_Homo sapiens_hsa034303.23518000
6Homologous recombination_Homo sapiens_hsa034402.87411154
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60473808
8Base excision repair_Homo sapiens_hsa034102.53363676
9Spliceosome_Homo sapiens_hsa030402.51217144
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50600066
11Nucleotide excision repair_Homo sapiens_hsa034202.45335308
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.43624910
13Non-homologous end-joining_Homo sapiens_hsa034502.37547429
14Fanconi anemia pathway_Homo sapiens_hsa034602.20139621
15Pyrimidine metabolism_Homo sapiens_hsa002402.17080185
16Basal transcription factors_Homo sapiens_hsa030222.14547684
17Primary immunodeficiency_Homo sapiens_hsa053402.05267496
18Cardiac muscle contraction_Homo sapiens_hsa042602.01677323
19RNA transport_Homo sapiens_hsa030131.84610617
20Cell cycle_Homo sapiens_hsa041101.80748291
21RNA degradation_Homo sapiens_hsa030181.70844773
22Protein export_Homo sapiens_hsa030601.69438590
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.53815326
24Tight junction_Homo sapiens_hsa045301.47034406
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.43449982
26Graft-versus-host disease_Homo sapiens_hsa053321.40727753
27Allograft rejection_Homo sapiens_hsa053301.37429763
28Herpes simplex infection_Homo sapiens_hsa051681.34718428
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30565025
30Purine metabolism_Homo sapiens_hsa002301.30173472
31p53 signaling pathway_Homo sapiens_hsa041151.26218726
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25845637
33Epstein-Barr virus infection_Homo sapiens_hsa051691.21452804
34Oocyte meiosis_Homo sapiens_hsa041141.20847302
35Measles_Homo sapiens_hsa051621.20319675
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.15624619
37Hematopoietic cell lineage_Homo sapiens_hsa046401.15206919
38Antigen processing and presentation_Homo sapiens_hsa046121.13256228
39Propanoate metabolism_Homo sapiens_hsa006401.13048380
40One carbon pool by folate_Homo sapiens_hsa006701.11739381
41Nitrogen metabolism_Homo sapiens_hsa009101.11106216
42Autoimmune thyroid disease_Homo sapiens_hsa053201.03957468
43Leishmaniasis_Homo sapiens_hsa051401.03519317
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02845256
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01414684
46Phototransduction_Homo sapiens_hsa047440.99097195
47Asthma_Homo sapiens_hsa053100.98659694
48Legionellosis_Homo sapiens_hsa051340.98242654
49Olfactory transduction_Homo sapiens_hsa047400.97095550
50mRNA surveillance pathway_Homo sapiens_hsa030150.93947926
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92694113
52Oxidative phosphorylation_Homo sapiens_hsa001900.91291165
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90474345
54Caffeine metabolism_Homo sapiens_hsa002320.88097338
55Butanoate metabolism_Homo sapiens_hsa006500.87599444
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86499271
57Systemic lupus erythematosus_Homo sapiens_hsa053220.85613840
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84618465
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82831120
60Parkinsons disease_Homo sapiens_hsa050120.80914335
61Huntingtons disease_Homo sapiens_hsa050160.79500154
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78752200
63Arachidonic acid metabolism_Homo sapiens_hsa005900.75924448
64Regulation of autophagy_Homo sapiens_hsa041400.75098565
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74834333
66Selenocompound metabolism_Homo sapiens_hsa004500.73073664
67Rheumatoid arthritis_Homo sapiens_hsa053230.73044447
68Malaria_Homo sapiens_hsa051440.71913214
69Influenza A_Homo sapiens_hsa051640.71053385
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70750996
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70198584
72Other glycan degradation_Homo sapiens_hsa005110.68895849
73Shigellosis_Homo sapiens_hsa051310.68243904
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.66249219
75Circadian rhythm_Homo sapiens_hsa047100.65136618
76Collecting duct acid secretion_Homo sapiens_hsa049660.63121870
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62159723
78Apoptosis_Homo sapiens_hsa042100.61298686
79Viral carcinogenesis_Homo sapiens_hsa052030.61077508
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60114458
81Nicotine addiction_Homo sapiens_hsa050330.60060412
82Pentose phosphate pathway_Homo sapiens_hsa000300.59773806
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59464062
84Pyruvate metabolism_Homo sapiens_hsa006200.59087826
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59017710
86B cell receptor signaling pathway_Homo sapiens_hsa046620.58505385
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.57406012
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55340165
89Folate biosynthesis_Homo sapiens_hsa007900.55158058
90Chemical carcinogenesis_Homo sapiens_hsa052040.54535451
91HTLV-I infection_Homo sapiens_hsa051660.54425550
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54226071
93Oxytocin signaling pathway_Homo sapiens_hsa049210.53894699
94T cell receptor signaling pathway_Homo sapiens_hsa046600.52843473
95Calcium signaling pathway_Homo sapiens_hsa040200.52159601
96Pertussis_Homo sapiens_hsa051330.51916420
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50118144
98Morphine addiction_Homo sapiens_hsa050320.49416686
99Hepatitis B_Homo sapiens_hsa051610.49123860
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48469704
101Sphingolipid metabolism_Homo sapiens_hsa006000.47598729
102Type I diabetes mellitus_Homo sapiens_hsa049400.47527170
103Peroxisome_Homo sapiens_hsa041460.46608324
104Osteoclast differentiation_Homo sapiens_hsa043800.46576771
105Circadian entrainment_Homo sapiens_hsa047130.44549778
106Sulfur relay system_Homo sapiens_hsa041220.44429315
107Tuberculosis_Homo sapiens_hsa051520.44030270
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42851609
109GABAergic synapse_Homo sapiens_hsa047270.41170681
110Tryptophan metabolism_Homo sapiens_hsa003800.39457665
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39267237
112Salmonella infection_Homo sapiens_hsa051320.36865093
113Alzheimers disease_Homo sapiens_hsa050100.35992469
114N-Glycan biosynthesis_Homo sapiens_hsa005100.35842575
115Wnt signaling pathway_Homo sapiens_hsa043100.35157544
116Dopaminergic synapse_Homo sapiens_hsa047280.34905290
117TNF signaling pathway_Homo sapiens_hsa046680.34771439
118Phagosome_Homo sapiens_hsa041450.33929992
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32949684
120Glutathione metabolism_Homo sapiens_hsa004800.32586533
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30780207
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30689420
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30565707
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30155268
125Viral myocarditis_Homo sapiens_hsa054160.29950936
126Fatty acid elongation_Homo sapiens_hsa000620.28406768
127Taste transduction_Homo sapiens_hsa047420.27991352
128Serotonergic synapse_Homo sapiens_hsa047260.27373294
129Toxoplasmosis_Homo sapiens_hsa051450.26655848
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26426147
131Renin secretion_Homo sapiens_hsa049240.26349889
132Chemokine signaling pathway_Homo sapiens_hsa040620.25684657
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25078926
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23839353
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.23402258
136Hedgehog signaling pathway_Homo sapiens_hsa043400.23326291
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23205449
138Ether lipid metabolism_Homo sapiens_hsa005650.22398598
139African trypanosomiasis_Homo sapiens_hsa051430.22392141
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21899389
141Retinol metabolism_Homo sapiens_hsa008300.20788273
142Insulin secretion_Homo sapiens_hsa049110.20710460
143Linoleic acid metabolism_Homo sapiens_hsa005910.20703903
144Metabolic pathways_Homo sapiens_hsa011000.20634277
145Hepatitis C_Homo sapiens_hsa051600.20629576
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.18700074

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