ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	respiratory chain complex IV assembly (GO:0008535)	4.52541862
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.38824058
3	cytochrome complex assembly (GO:0017004)	4.13787179
4	DNA deamination (GO:0045006)	3.91165871
5	positive regulation of mitochondrial fission (GO:0090141)	3.83698985
6	inositol phosphate catabolic process (GO:0071545)	3.59071630
7	rRNA modification (GO:0000154)	3.55185658
8	preassembly of GPI anchor in ER membrane (GO:0016254)	3.46997227
9	protein complex biogenesis (GO:0070271)	3.45727144
10	piRNA metabolic process (GO:0034587)	3.42862339
11	proteasome assembly (GO:0043248)	3.38914308
12	adenosine metabolic process (GO:0046085)	3.35108002
13	rRNA methylation (GO:0031167)	3.34587809
14	cellular ketone body metabolic process (GO:0046950)	3.31026979
15	platelet dense granule organization (GO:0060155)	3.22596384
16	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.16235403
17	inositol phosphate dephosphorylation (GO:0046855)	3.16235403
18	response to pheromone (GO:0019236)	3.14697570
19	ketone body metabolic process (GO:1902224)	3.11127371
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08501259
21	cytidine deamination (GO:0009972)	3.05291710
22	cytidine metabolic process (GO:0046087)	3.05291710
23	cytidine catabolic process (GO:0006216)	3.05291710
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.97484011
25	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.94787826
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.93310040
27	polyol catabolic process (GO:0046174)	2.90725107
28	NADH dehydrogenase complex assembly (GO:0010257)	2.89627044
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.89627044
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.89627044
31	mannosylation (GO:0097502)	2.89436429
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.83265615
33	ATP synthesis coupled proton transport (GO:0015986)	2.83265615
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.82928419
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.82211924
36	DNA double-strand break processing (GO:0000729)	2.80059944
37	C-terminal protein lipidation (GO:0006501)	2.79573678
38	protein K6-linked ubiquitination (GO:0085020)	2.76461507
39	vitamin biosynthetic process (GO:0009110)	2.75616011
40	actin nucleation (GO:0045010)	2.71808265
41	DNA methylation involved in gamete generation (GO:0043046)	2.71511225
42	aldehyde catabolic process (GO:0046185)	2.70680620
43	ubiquinone biosynthetic process (GO:0006744)	2.70412188
44	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.69185167
45	respiratory electron transport chain (GO:0022904)	2.65408943
46	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.65320766
47	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.64052037
48	protein deneddylation (GO:0000338)	2.63815125
49	electron transport chain (GO:0022900)	2.63799905
50	synapsis (GO:0007129)	2.60660514
51	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.59194754
52	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.56800973
53	maturation of 5.8S rRNA (GO:0000460)	2.56784219
54	ATP hydrolysis coupled proton transport (GO:0015991)	2.56537123
55	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.56537123
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56316506
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56316506
58	regulation of mitochondrial fission (GO:0090140)	2.54368624
59	anterograde synaptic vesicle transport (GO:0048490)	2.53985072
60	GPI anchor biosynthetic process (GO:0006506)	2.53850403
61	C-terminal protein amino acid modification (GO:0018410)	2.52463315
62	GPI anchor metabolic process (GO:0006505)	2.51656365
63	cullin deneddylation (GO:0010388)	2.51576195
64	dopamine transport (GO:0015872)	2.51359876
65	S-adenosylmethionine metabolic process (GO:0046500)	2.51034027
66	amino acid salvage (GO:0043102)	2.49742980
67	L-methionine salvage (GO:0071267)	2.49742980
68	L-methionine biosynthetic process (GO:0071265)	2.49742980
69	protein-cofactor linkage (GO:0018065)	2.49594203
70	branched-chain amino acid catabolic process (GO:0009083)	2.48789516
71	negative regulation of neurological system process (GO:0031645)	2.47473511
72	terpenoid biosynthetic process (GO:0016114)	2.44901221
73	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44299382
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.43491399
75	metallo-sulfur cluster assembly (GO:0031163)	2.43489160
76	iron-sulfur cluster assembly (GO:0016226)	2.43489160
77	positive regulation of defense response to virus by host (GO:0002230)	2.42206498
78	negative regulation of membrane potential (GO:0045837)	2.41471341
79	regulation of glucokinase activity (GO:0033131)	2.41157460
80	regulation of hexokinase activity (GO:1903299)	2.41157460
81	ubiquinone metabolic process (GO:0006743)	2.40446323
82	nucleotide transmembrane transport (GO:1901679)	2.39769473
83	signal peptide processing (GO:0006465)	2.39688052
84	proton transport (GO:0015992)	2.37357477
85	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.37292689
86	regulation of meiosis I (GO:0060631)	2.37287957
87	tolerance induction (GO:0002507)	2.36339875
88	hydrogen transport (GO:0006818)	2.33032284
89	adaptation of signaling pathway (GO:0023058)	2.32425372
90	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.32152164
91	hydrogen ion transmembrane transport (GO:1902600)	2.30959853
92	glycolipid biosynthetic process (GO:0009247)	2.30005273
93	kynurenine metabolic process (GO:0070189)	2.29336491
94	glucosamine-containing compound catabolic process (GO:1901072)	2.29261811
95	quinone biosynthetic process (GO:1901663)	2.29236452
96	L-fucose catabolic process (GO:0042355)	2.29173137
97	fucose catabolic process (GO:0019317)	2.29173137
98	L-fucose metabolic process (GO:0042354)	2.29173137
99	indolalkylamine metabolic process (GO:0006586)	2.28987624
100	peptidyl-histidine modification (GO:0018202)	2.27830747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65968691
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.60336168
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.42790857
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.18425089
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10027538
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98490250
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.90202057
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.66607371
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55669314
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53202381
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.51320749
12	VDR_22108803_ChIP-Seq_LS180_Human	2.28208425
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26257305
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24079746
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.20467192
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14516008
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09429461
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08514088
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92906154
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89043458
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.85793168
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.77988542
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77826700
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.76132324
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.75464724
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.72838437
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.70238868
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.66448517
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.65704384
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.65060552
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.64729448
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63142778
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58156018
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56794532
35	GATA3_26560356_Chip-Seq_TH2_Human	1.51072682
36	AR_20517297_ChIP-Seq_VCAP_Human	1.50705297
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47279294
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.47006836
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45565369
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.44879002
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43496520
42	EWS_26573619_Chip-Seq_HEK293_Human	1.42546285
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38847089
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34983250
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34983250
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.34588512
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33374575
48	FUS_26573619_Chip-Seq_HEK293_Human	1.32470986
49	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31011407
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30210410
51	P300_19829295_ChIP-Seq_ESCs_Human	1.29382827
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.28589228
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25056129
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24119040
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23934470
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.23934470
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20926976
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19936188
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19695085
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.16688385
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.15931321
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14588058
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14277973
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14269136
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14269136
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13464567
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13008322
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12400209
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11977030
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10785617
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09905701
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08225765
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07481971
74	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04855857
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.04621470
76	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04382539
77	MYB_26560356_Chip-Seq_TH2_Human	1.04010778
78	TFEB_21752829_ChIP-Seq_HELA_Human	1.02748636
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.01960447
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01357688
81	SPI1_23547873_ChIP-Seq_NB4_Human	1.00681091
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00278698
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.99642135
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98912890
85	AR_25329375_ChIP-Seq_VCAP_Human	0.98355318
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98203658
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97810996
88	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97228238
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96428934
90	TCF4_23295773_ChIP-Seq_U87_Human	0.95140916
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94891768
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93970708
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93937256
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.92844750
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92760773
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92270842
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91483246
98	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.91260585
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90965680
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90286359

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.25382204
2	MP0000372_irregular_coat_pigmentation	3.24392638
3	MP0002837_dystrophic_cardiac_calcinosis	3.04337300
4	MP0005646_abnormal_pituitary_gland	2.97026805
5	MP0008877_abnormal_DNA_methylation	2.46611758
6	MP0003195_calcinosis	2.40768142
7	MP0004147_increased_porphyrin_level	2.29896206
8	MP0002102_abnormal_ear_morphology	2.22498100
9	MP0001835_abnormal_antigen_presentation	2.20459696
10	MP0006072_abnormal_retinal_apoptosis	2.09285978
11	MP0006036_abnormal_mitochondrial_physio	2.00604899
12	MP0000569_abnormal_digit_pigmentation	1.92544518
13	MP0005671_abnormal_response_to	1.87900644
14	MP0005075_abnormal_melanosome_morpholog	1.86652969
15	MP0001764_abnormal_homeostasis	1.70848032
16	MP0002876_abnormal_thyroid_physiology	1.69410688
17	MP0005084_abnormal_gallbladder_morpholo	1.69393992
18	MP0005379_endocrine/exocrine_gland_phen	1.61984312
19	MP0008872_abnormal_physiological_respon	1.60782771
20	MP0006054_spinal_hemorrhage	1.59079447
21	MP0005332_abnormal_amino_acid	1.56851465
22	MP0002138_abnormal_hepatobiliary_system	1.54993507
23	MP0003186_abnormal_redox_activity	1.54947133
24	MP0001968_abnormal_touch/_nociception	1.51984761
25	MP0009697_abnormal_copulation	1.49130573
26	MP0008875_abnormal_xenobiotic_pharmacok	1.48667574
27	MP0002693_abnormal_pancreas_physiology	1.45954210
28	MP0009785_altered_susceptibility_to	1.42388405
29	MP0001800_abnormal_humoral_immune	1.40522003
30	MP0001984_abnormal_olfaction	1.38521876
31	MP0002163_abnormal_gland_morphology	1.37018743
32	MP0003172_abnormal_lysosome_physiology	1.36608824
33	MP0003786_premature_aging	1.34304275
34	MP0003252_abnormal_bile_duct	1.33273706
35	MP0008058_abnormal_DNA_repair	1.32428750
36	MP0005551_abnormal_eye_electrophysiolog	1.32411067
37	MP0006035_abnormal_mitochondrial_morpho	1.30627376
38	MP0002166_altered_tumor_susceptibility	1.30290986
39	MP0001529_abnormal_vocalization	1.29963011
40	MP0000685_abnormal_immune_system	1.29728689
41	MP0005410_abnormal_fertilization	1.29396132
42	MP0005636_abnormal_mineral_homeostasis	1.29186149
43	MP0005645_abnormal_hypothalamus_physiol	1.24436921
44	MP0001501_abnormal_sleep_pattern	1.22987871
45	MP0003724_increased_susceptibility_to	1.22862356
46	MP0005253_abnormal_eye_physiology	1.22418685
47	MP0009046_muscle_twitch	1.21722878
48	MP0003656_abnormal_erythrocyte_physiolo	1.21146451
49	MP0002723_abnormal_immune_serum	1.20965615
50	MP0002148_abnormal_hypersensitivity_rea	1.20851061
51	MP0005220_abnormal_exocrine_pancreas	1.17266223
52	MP0000015_abnormal_ear_pigmentation	1.16073268
53	MP0004043_abnormal_pH_regulation	1.15965443
54	MP0005000_abnormal_immune_tolerance	1.15734866
55	MP0005389_reproductive_system_phenotype	1.14899543
56	MP0001919_abnormal_reproductive_system	1.14877893
57	MP0001986_abnormal_taste_sensitivity	1.11852782
58	MP0004885_abnormal_endolymph	1.09963542
59	MP0005464_abnormal_platelet_physiology	1.09506986
60	MP0003787_abnormal_imprinting	1.09143934
61	MP0002139_abnormal_hepatobiliary_system	1.04688719
62	MP0005408_hypopigmentation	1.03771993
63	MP0002452_abnormal_antigen_presenting	1.03392614
64	MP0003718_maternal_effect	1.03324784
65	MP0002160_abnormal_reproductive_system	1.02409807
66	MP0002006_tumorigenesis	0.97833839
67	MP0004145_abnormal_muscle_electrophysio	0.97343363
68	MP0005174_abnormal_tail_pigmentation	0.95535994
69	MP0010329_abnormal_lipoprotein_level	0.95289403
70	MP0001944_abnormal_pancreas_morphology	0.95214585
71	MP0005365_abnormal_bile_salt	0.94819929
72	MP0001845_abnormal_inflammatory_respons	0.94408693
73	MP0000516_abnormal_urinary_system	0.93854814
74	MP0005367_renal/urinary_system_phenotyp	0.93854814
75	MP0002751_abnormal_autonomic_nervous	0.92505637
76	MP0001661_extended_life_span	0.92487078
77	MP0002736_abnormal_nociception_after	0.91736152
78	MP0004142_abnormal_muscle_tone	0.91709932
79	MP0002909_abnormal_adrenal_gland	0.91638336
80	MP0001905_abnormal_dopamine_level	0.91453442
81	MP0002420_abnormal_adaptive_immunity	0.90860653
82	MP0001819_abnormal_immune_cell	0.90802652
83	MP0002095_abnormal_skin_pigmentation	0.88189773
84	MP0001765_abnormal_ion_homeostasis	0.87508934
85	MP0002272_abnormal_nervous_system	0.87493863
86	MP0000427_abnormal_hair_cycle	0.87162077
87	MP0005360_urolithiasis	0.86416741
88	MP0005085_abnormal_gallbladder_physiolo	0.85626106
89	MP0002928_abnormal_bile_duct	0.84201337
90	MP0001790_abnormal_immune_system	0.82791778
91	MP0005387_immune_system_phenotype	0.82791778
92	MP0000358_abnormal_cell_content/	0.81189788
93	MP0008469_abnormal_protein_level	0.80975582
94	MP0005266_abnormal_metabolism	0.80938021
95	MP0000689_abnormal_spleen_morphology	0.80872108
96	MP0004924_abnormal_behavior	0.80171665
97	MP0005386_behavior/neurological_phenoty	0.80171665
98	MP0009745_abnormal_behavioral_response	0.79814115
99	MP0000613_abnormal_salivary_gland	0.77552771
100	MP0002398_abnormal_bone_marrow	0.77281244

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	3.86365697
2	Hepatic necrosis (HP:0002605)	3.61067334
3	Renal cortical cysts (HP:0000803)	3.46232511
4	Hepatocellular necrosis (HP:0001404)	3.45056663
5	Mitochondrial inheritance (HP:0001427)	3.44624225
6	Increased CSF lactate (HP:0002490)	3.41360859
7	3-Methylglutaconic aciduria (HP:0003535)	3.32286148
8	Acute necrotizing encephalopathy (HP:0006965)	3.31245808
9	Renal Fanconi syndrome (HP:0001994)	3.23202383
10	Progressive macrocephaly (HP:0004481)	3.23131112
11	Increased hepatocellular lipid droplets (HP:0006565)	3.23055296
12	Lipid accumulation in hepatocytes (HP:0006561)	3.12076484
13	Methylmalonic acidemia (HP:0002912)	3.08004551
14	Acute encephalopathy (HP:0006846)	3.06553674
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94978831
16	Tongue fasciculations (HP:0001308)	2.83826909
17	Ketoacidosis (HP:0001993)	2.77411435
18	Abnormality of the renal cortex (HP:0011035)	2.70256841
19	Severe combined immunodeficiency (HP:0004430)	2.66767584
20	Methylmalonic aciduria (HP:0012120)	2.66710527
21	Glycosuria (HP:0003076)	2.60353058
22	Abnormality of urine glucose concentration (HP:0011016)	2.60353058
23	Stomatitis (HP:0010280)	2.60193366
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.58364003
25	Thyroiditis (HP:0100646)	2.54237085
26	Pancreatic cysts (HP:0001737)	2.53399883
27	Increased serum lactate (HP:0002151)	2.51455383
28	Medial flaring of the eyebrow (HP:0010747)	2.38813172
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34913792
30	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.34335454
31	Aplasia/hypoplasia of the uterus (HP:0008684)	2.34011005
32	Lactic acidosis (HP:0003128)	2.33680973
33	Molar tooth sign on MRI (HP:0002419)	2.32625606
34	Abnormality of midbrain morphology (HP:0002418)	2.32625606
35	Muscle fibrillation (HP:0010546)	2.31480427
36	Pancreatic fibrosis (HP:0100732)	2.30912973
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.28727862
38	Dicarboxylic aciduria (HP:0003215)	2.28727862
39	Increased intramyocellular lipid droplets (HP:0012240)	2.26938508
40	Abnormality of vitamin B metabolism (HP:0004340)	2.26858417
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26692495
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26692495
43	Ketosis (HP:0001946)	2.26524733
44	Optic disc pallor (HP:0000543)	2.25713934
45	Nephronophthisis (HP:0000090)	2.24580289
46	Exertional dyspnea (HP:0002875)	2.24456860
47	Abnormal protein glycosylation (HP:0012346)	2.23376683
48	Abnormal glycosylation (HP:0012345)	2.23376683
49	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.23376683
50	Abnormal protein N-linked glycosylation (HP:0012347)	2.23376683
51	Abolished electroretinogram (ERG) (HP:0000550)	2.22681092
52	Cerebral edema (HP:0002181)	2.21065407
53	Abnormality of renal resorption (HP:0011038)	2.19968296
54	Respiratory failure (HP:0002878)	2.16732259
55	IgG deficiency (HP:0004315)	2.11978668
56	Hypoproteinemia (HP:0003075)	2.11240556
57	Abnormality of dental color (HP:0011073)	2.10741085
58	Congenital stationary night blindness (HP:0007642)	2.04327521
59	Hypoglycemic coma (HP:0001325)	2.04292305
60	Hypoplasia of the uterus (HP:0000013)	2.01678558
61	Lethargy (HP:0001254)	2.00078728
62	Abnormality of methionine metabolism (HP:0010901)	1.99599705
63	Combined immunodeficiency (HP:0005387)	1.99219521
64	Abnormality of B cell number (HP:0010975)	1.99085343
65	Progressive inability to walk (HP:0002505)	1.98666414
66	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.98533106
67	Type I transferrin isoform profile (HP:0003642)	1.96528139
68	Chronic diarrhea (HP:0002028)	1.92784616
69	Increased muscle lipid content (HP:0009058)	1.91293143
70	Generalized aminoaciduria (HP:0002909)	1.89863021
71	Polydipsia (HP:0001959)	1.86721000
72	Abnormal drinking behavior (HP:0030082)	1.86721000
73	Large for gestational age (HP:0001520)	1.86400206
74	Abnormality of the renal medulla (HP:0100957)	1.85815889
75	True hermaphroditism (HP:0010459)	1.84425831
76	CNS demyelination (HP:0007305)	1.83048246
77	Attenuation of retinal blood vessels (HP:0007843)	1.82207835
78	Abnormality of the prostate (HP:0008775)	1.81576137
79	Chronic hepatic failure (HP:0100626)	1.81410976
80	Hyperinsulinemic hypoglycemia (HP:0000825)	1.80320392
81	Nephrogenic diabetes insipidus (HP:0009806)	1.80117697
82	B lymphocytopenia (HP:0010976)	1.78850670
83	Congenital, generalized hypertrichosis (HP:0004540)	1.78569758
84	Hyperphosphaturia (HP:0003109)	1.77211919
85	Type II lissencephaly (HP:0007260)	1.76802269
86	Proximal tubulopathy (HP:0000114)	1.75786382
87	Vacuolated lymphocytes (HP:0001922)	1.75708928
88	Panhypogammaglobulinemia (HP:0003139)	1.75165935
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.75049190
90	Elevated erythrocyte sedimentation rate (HP:0003565)	1.74159989
91	Abnormality of macular pigmentation (HP:0008002)	1.73283102
92	Abnormality of the anterior horn cell (HP:0006802)	1.72378523
93	Degeneration of anterior horn cells (HP:0002398)	1.72378523
94	Petechiae (HP:0000967)	1.72168339
95	Emotional lability (HP:0000712)	1.72072267
96	Pancreatic islet-cell hyperplasia (HP:0004510)	1.71657929
97	Progressive microcephaly (HP:0000253)	1.71282556
98	Congenital primary aphakia (HP:0007707)	1.70228914
99	Hypomagnesemia (HP:0002917)	1.69107820
100	Anhidrosis (HP:0000970)	1.68852068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.37889793
2	MAP4K2	3.34737234
3	BMPR1B	3.29640994
4	MAP3K12	3.02390438
5	TAOK3	3.00276645
6	EIF2AK3	2.91819150
7	BMPR2	2.90906895
8	TXK	2.38472773
9	PASK	2.37283066
10	WNK3	2.10927057
11	EIF2AK1	2.06735374
12	ERBB3	2.06679864
13	MST4	1.93715496
14	STK16	1.92611981
15	ADRBK2	1.87808553
16	NUAK1	1.83643634
17	MAPK13	1.59758055
18	RIPK4	1.58634902
19	BCKDK	1.57953661
20	CAMKK2	1.54551229
21	TEC	1.51952711
22	MAP3K14	1.46285402
23	BCR	1.45244792
24	PLK2	1.40834184
25	TRIM28	1.35116258
26	GRK1	1.33655123
27	PHKG1	1.26132777
28	PHKG2	1.26132777
29	ACVR1B	1.25130426
30	IKBKB	1.19846391
31	TLK1	1.17778502
32	MAPKAPK3	1.16069416
33	CSNK1G3	1.13394343
34	CDK8	1.12472921
35	PINK1	1.08295278
36	ZAK	1.06003324
37	CSNK1G2	0.99006553
38	TESK2	0.96765591
39	SYK	0.93545068
40	ITK	0.91791182
41	CSNK1G1	0.89300148
42	MATK	0.88241341
43	TNK2	0.86347016
44	CSNK1A1L	0.81290363
45	WNK4	0.79174454
46	PRKCQ	0.78634461
47	PTK2B	0.77384312
48	DAPK2	0.75031406
49	EIF2AK2	0.73989116
50	KIT	0.73617773
51	TGFBR1	0.73338265
52	SIK3	0.73008970
53	PRKCE	0.72435660
54	TRPM7	0.72005752
55	PAK3	0.71590580
56	FLT3	0.71009771
57	PLK3	0.69832491
58	DAPK1	0.69791519
59	CSF1R	0.69419502
60	PLK4	0.69386792
61	MAP2K6	0.65204766
62	GRK6	0.64174884
63	MARK3	0.64099841
64	MAP4K1	0.63904022
65	CCNB1	0.63644716
66	IKBKE	0.61280879
67	LYN	0.60920462
68	FGFR2	0.58592271
69	LCK	0.58211566
70	CAMKK1	0.57610361
71	BTK	0.56274086
72	INSRR	0.55492098
73	CLK1	0.53732062
74	BRSK2	0.50059710
75	LIMK1	0.49665600
76	STK38L	0.49231270
77	PRKCI	0.49103716
78	MYLK	0.48867387
79	ADRBK1	0.48052510
80	GRK7	0.47008816
81	SCYL2	0.46754318
82	IRAK1	0.44044545
83	VRK1	0.41574827
84	RPS6KA4	0.41255448
85	CSNK1A1	0.39668301
86	ABL1	0.38555622
87	OXSR1	0.37812633
88	PIK3CG	0.37667810
89	TBK1	0.35737702
90	GRK5	0.34317196
91	STK3	0.33215078
92	CHUK	0.33009927
93	HCK	0.30706749
94	RPS6KB2	0.29881533
95	IGF1R	0.28512795
96	PRKCG	0.27774685
97	JAK1	0.27625731
98	MINK1	0.25500913
99	ZAP70	0.25194084
100	PRKCA	0.24851922

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.64659871
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.94006838
3	Type I diabetes mellitus_Homo sapiens_hsa04940	2.85770815
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.71326069
5	Asthma_Homo sapiens_hsa05310	2.67950498
6	Proteasome_Homo sapiens_hsa03050	2.56612788
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.45976298
8	Allograft rejection_Homo sapiens_hsa05330	2.41464537
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.31592059
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.29143496
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.27542071
12	Parkinsons disease_Homo sapiens_hsa05012	2.12465695
13	Collecting duct acid secretion_Homo sapiens_hsa04966	2.09447192
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91698613
15	Phototransduction_Homo sapiens_hsa04744	1.89932283
16	Butanoate metabolism_Homo sapiens_hsa00650	1.87222249
17	Regulation of autophagy_Homo sapiens_hsa04140	1.84567583
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74880092
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.69700555
20	Basal transcription factors_Homo sapiens_hsa03022	1.65496022
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.59774151
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59463149
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.57180164
24	Fatty acid elongation_Homo sapiens_hsa00062	1.56940587
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48658926
26	Peroxisome_Homo sapiens_hsa04146	1.42483859
27	RNA degradation_Homo sapiens_hsa03018	1.36546250
28	RNA polymerase_Homo sapiens_hsa03020	1.36186299
29	Homologous recombination_Homo sapiens_hsa03440	1.33039299
30	Propanoate metabolism_Homo sapiens_hsa00640	1.32547138
31	Sulfur metabolism_Homo sapiens_hsa00920	1.31390011
32	Alzheimers disease_Homo sapiens_hsa05010	1.28534891
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26748793
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19986730
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17769530
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.17683022
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12448697
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.11985920
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.02122874
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.02101832
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.00368896
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.99940022
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97531734
44	Huntingtons disease_Homo sapiens_hsa05016	0.96516653
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96169331
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96083711
47	Caffeine metabolism_Homo sapiens_hsa00232	0.91987123
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89538723
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.84710102
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.84219826
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73919381
52	Purine metabolism_Homo sapiens_hsa00230	0.72812643
53	Circadian rhythm_Homo sapiens_hsa04710	0.72649954
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71099399
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71023707
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70998408
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69193512
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68946849
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68709495
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66915468
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66891555
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.66600855
63	Metabolic pathways_Homo sapiens_hsa01100	0.65485408
64	Olfactory transduction_Homo sapiens_hsa04740	0.63274357
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.63124776
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62993845
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.62419475
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62217771
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62026435
70	Insulin secretion_Homo sapiens_hsa04911	0.61159792
71	One carbon pool by folate_Homo sapiens_hsa00670	0.58311526
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.55574550
73	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.55488574
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.53796709
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53657106
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51219348
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50614536
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50132558
79	Viral myocarditis_Homo sapiens_hsa05416	0.48299631
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47344755
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46704189
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45599690
83	Lysosome_Homo sapiens_hsa04142	0.45525411
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45421985
85	Mismatch repair_Homo sapiens_hsa03430	0.45084327
86	Shigellosis_Homo sapiens_hsa05131	0.43748896
87	Retinol metabolism_Homo sapiens_hsa00830	0.41180744
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39934085
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38877232
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37123038
91	Legionellosis_Homo sapiens_hsa05134	0.36828976
92	Herpes simplex infection_Homo sapiens_hsa05168	0.36287816
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34407448
94	Leishmaniasis_Homo sapiens_hsa05140	0.33979278
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33670649
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.33125870
97	RNA transport_Homo sapiens_hsa03013	0.32813892
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32580977
99	Glutathione metabolism_Homo sapiens_hsa00480	0.30423857
100	Folate biosynthesis_Homo sapiens_hsa00790	0.29817840

FRG1BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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