ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.15810014
2	aldehyde catabolic process (GO:0046185)	3.99014041
3	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.83545043
4	regulation of cytokine secretion involved in immune response (GO:0002739)	3.76147047
5	platelet dense granule organization (GO:0060155)	3.68027484
6	very-low-density lipoprotein particle assembly (GO:0034379)	3.56901919
7	xenobiotic catabolic process (GO:0042178)	3.35362452
8	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.33211280
9	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.30918169
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.18737442
11	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	3.15354965
12	regulation of hypersensitivity (GO:0002883)	3.11005170
13	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.10091352
14	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.04301378
15	adenosine metabolic process (GO:0046085)	2.95120811
16	oxidative phosphorylation (GO:0006119)	2.88135019
17	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.87414127
18	plasma lipoprotein particle assembly (GO:0034377)	2.85794998
19	regulation of T-helper 1 cell differentiation (GO:0045625)	2.79896919
20	regulation of interferon-alpha production (GO:0032647)	2.78669752
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.77467936
22	L-phenylalanine catabolic process (GO:0006559)	2.77467936
23	ribonucleoprotein complex disassembly (GO:0032988)	2.76074336
24	regulation of cholesterol esterification (GO:0010872)	2.74580270
25	regulation of metalloenzyme activity (GO:0048552)	2.74344135
26	mannosylation (GO:0097502)	2.66846574
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61955418
28	protein-lipid complex assembly (GO:0065005)	2.59285498
29	regulation of chemokine biosynthetic process (GO:0045073)	2.58890611
30	proteasome assembly (GO:0043248)	2.58664249
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.58636069
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.58636069
33	NADH dehydrogenase complex assembly (GO:0010257)	2.58636069
34	organelle disassembly (GO:1903008)	2.57112960
35	negative regulation of mast cell activation (GO:0033004)	2.56031599
36	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.55673463
37	positive regulation of interferon-alpha production (GO:0032727)	2.54879629
38	aromatic amino acid family catabolic process (GO:0009074)	2.53924715
39	positive regulation of interferon-beta production (GO:0032728)	2.53425120
40	protein complex biogenesis (GO:0070271)	2.51476797
41	rRNA modification (GO:0000154)	2.50524740
42	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.47862533
43	daunorubicin metabolic process (GO:0044597)	2.44815856
44	polyketide metabolic process (GO:0030638)	2.44815856
45	doxorubicin metabolic process (GO:0044598)	2.44815856
46	L-phenylalanine metabolic process (GO:0006558)	2.41229230
47	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.41229230
48	respiratory chain complex IV assembly (GO:0008535)	2.39339659
49	inositol phosphate catabolic process (GO:0071545)	2.38990221
50	cholesterol efflux (GO:0033344)	2.38187292
51	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.37185832
52	rRNA methylation (GO:0031167)	2.36879545
53	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.35831161
54	positive regulation of mast cell degranulation (GO:0043306)	2.35831161
55	cellular response to thyroid hormone stimulus (GO:0097067)	2.34855602
56	regulation of glucokinase activity (GO:0033131)	2.34372725
57	regulation of hexokinase activity (GO:1903299)	2.34372725
58	cellular respiration (GO:0045333)	2.33704576
59	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.33561770
60	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.33443069
61	tryptophan catabolic process (GO:0006569)	2.32997408
62	indole-containing compound catabolic process (GO:0042436)	2.32997408
63	indolalkylamine catabolic process (GO:0046218)	2.32997408
64	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.32821694
65	mature B cell differentiation involved in immune response (GO:0002313)	2.31320082
66	regulation of interleukin-8 secretion (GO:2000482)	2.30798010
67	low-density lipoprotein particle remodeling (GO:0034374)	2.30293867
68	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.30123779
69	ribosomal large subunit biogenesis (GO:0042273)	2.28977459
70	membrane raft organization (GO:0031579)	2.28009877
71	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.26238995
72	cytochrome complex assembly (GO:0017004)	2.24239585
73	positive regulation of response to biotic stimulus (GO:0002833)	2.24067477
74	regulation of interleukin-1 beta secretion (GO:0050706)	2.23891246
75	regulation of germinal center formation (GO:0002634)	2.23727919
76	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.22945323
77	membrane budding (GO:0006900)	2.22139967
78	cellular ketone body metabolic process (GO:0046950)	2.21676370
79	branched-chain amino acid catabolic process (GO:0009083)	2.21462325
80	positive regulation of interleukin-17 production (GO:0032740)	2.21140644
81	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.20062770
82	positive regulation of monocyte chemotaxis (GO:0090026)	2.19346019
83	positive regulation of mast cell activation (GO:0033005)	2.18657727
84	regulation of immunoglobulin secretion (GO:0051023)	2.17937427
85	kynurenine metabolic process (GO:0070189)	2.16978060
86	immunoglobulin mediated immune response (GO:0016064)	2.16720744
87	phagocytosis, engulfment (GO:0006911)	2.15023863
88	aerobic respiration (GO:0009060)	2.14720837
89	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.14151665
90	inositol phosphate dephosphorylation (GO:0046855)	2.14151665
91	mast cell activation (GO:0045576)	2.14031342
92	tryptophan metabolic process (GO:0006568)	2.13757630
93	aminoglycoside antibiotic metabolic process (GO:0030647)	2.13356281
94	regulation of myeloid cell apoptotic process (GO:0033032)	2.12804337
95	negative regulation of lipid storage (GO:0010888)	2.10749940
96	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.10647269
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.10642726
98	regulation of alpha-beta T cell proliferation (GO:0046640)	2.09127130
99	regulation of interferon-beta production (GO:0032648)	2.08367938
100	regulation of triglyceride catabolic process (GO:0010896)	2.08185260

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52127434
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.24450851
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.09782312
4	ELK1_19687146_ChIP-ChIP_HELA_Human	2.82009932
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.70917287
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.37986951
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.35885314
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.26672176
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25547592
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.22571772
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.12566301
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.11033343
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.03558552
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.98066375
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.96926137
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.95130881
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.94808189
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.92680892
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.90214350
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.89566078
21	VDR_22108803_ChIP-Seq_LS180_Human	1.79983274
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78600504
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76773410
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.74271305
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.72232902
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66738576
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63015163
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61031460
29	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.57004256
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55103677
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54949129
32	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.49749629
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48487482
34	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.48151158
35	SPI1_23547873_ChIP-Seq_NB4_Human	1.45845358
36	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.45469664
37	GATA3_26560356_Chip-Seq_TH2_Human	1.41525491
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40591027
39	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.34870061
40	P300_19829295_ChIP-Seq_ESCs_Human	1.34668178
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33188236
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31898187
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30591192
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29653910
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.28969960
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.26537567
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25988333
48	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25466165
49	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23219094
50	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23163572
51	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.22454783
52	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.22454783
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21546583
54	FUS_26573619_Chip-Seq_HEK293_Human	1.21026075
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20587248
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19516442
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19348669
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19348669
59	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18212048
60	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.18175196
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17464561
62	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.16843681
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16739998
64	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.16259823
65	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.16169386
66	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.15814792
67	EWS_26573619_Chip-Seq_HEK293_Human	1.15628292
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15595441
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15049798
70	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.14882912
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12589135
72	AR_20517297_ChIP-Seq_VCAP_Human	1.12578842
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11415014
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11415014
75	CDX2_22108803_ChIP-Seq_LS180_Human	1.10452969
76	MYB_26560356_Chip-Seq_TH2_Human	1.09511362
77	TFEB_21752829_ChIP-Seq_HELA_Human	1.07769394
78	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06861571
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06830779
80	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.05139725
81	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.04528110
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03825862
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03348762
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.02971921
85	BRD4_25478319_ChIP-Seq_HGPS_Human	1.02705098
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.01826811
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01765388
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.01582534
89	GABP_19822575_ChIP-Seq_HepG2_Human	1.01263948
90	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.00461202
91	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99889181
92	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.99875106
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99782571
94	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.97228572
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97222659
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96239637
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.95522128
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95522128
99	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.95279038
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.95170556

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	3.84322268
2	MP0006054_spinal_hemorrhage	3.39993342
3	MP0003806_abnormal_nucleotide_metabolis	3.13735173
4	MP0003950_abnormal_plasma_membrane	2.96267674
5	MP0000569_abnormal_digit_pigmentation	2.58488263
6	MP0003195_calcinosis	2.57130348
7	MP0009785_altered_susceptibility_to	2.54002504
8	MP0005671_abnormal_response_to	2.49079613
9	MP0005084_abnormal_gallbladder_morpholo	2.32917978
10	MP0001545_abnormal_hematopoietic_system	2.26510727
11	MP0005397_hematopoietic_system_phenotyp	2.26510727
12	MP0001835_abnormal_antigen_presentation	2.25549693
13	MP0009697_abnormal_copulation	2.18749794
14	MP0006082_CNS_inflammation	2.15600245
15	MP0002148_abnormal_hypersensitivity_rea	2.14730316
16	MP0002163_abnormal_gland_morphology	2.04096558
17	MP0003656_abnormal_erythrocyte_physiolo	1.97883178
18	MP0005085_abnormal_gallbladder_physiolo	1.89200050
19	MP0004147_increased_porphyrin_level	1.88687721
20	MP0006036_abnormal_mitochondrial_physio	1.84550675
21	MP0005464_abnormal_platelet_physiology	1.77464238
22	MP0003252_abnormal_bile_duct	1.77202378
23	MP0002837_dystrophic_cardiac_calcinosis	1.74955454
24	MP0005379_endocrine/exocrine_gland_phen	1.72939294
25	MP0001764_abnormal_homeostasis	1.72781289
26	MP0003186_abnormal_redox_activity	1.72239525
27	MP0002132_abnormal_respiratory_system	1.65460258
28	MP0002102_abnormal_ear_morphology	1.61914741
29	MP0001853_heart_inflammation	1.61795090
30	MP0005365_abnormal_bile_salt	1.59501129
31	MP0008875_abnormal_xenobiotic_pharmacok	1.52327967
32	MP0008469_abnormal_protein_level	1.50581004
33	MP0003191_abnormal_cellular_cholesterol	1.47771092
34	MP0010329_abnormal_lipoprotein_level	1.46933486
35	MP0005360_urolithiasis	1.46447054
36	MP0002419_abnormal_innate_immunity	1.44674195
37	MP0005000_abnormal_immune_tolerance	1.43507933
38	MP0005058_abnormal_lysosome_morphology	1.42464029
39	MP0003436_decreased_susceptibility_to	1.40473784
40	MP0005025_abnormal_response_to	1.38108538
41	MP0002138_abnormal_hepatobiliary_system	1.33574569
42	MP0003172_abnormal_lysosome_physiology	1.33377176
43	MP0001661_extended_life_span	1.32955587
44	MP0002723_abnormal_immune_serum	1.31058622
45	MP0000685_abnormal_immune_system	1.29968429
46	MP0004883_abnormal_blood_vessel	1.28848485
47	MP0001845_abnormal_inflammatory_respons	1.26911380
48	MP0005164_abnormal_response_to	1.26120632
49	MP0005332_abnormal_amino_acid	1.25550244
50	MP0008058_abnormal_DNA_repair	1.24048359
51	MP0002452_abnormal_antigen_presenting	1.22693522
52	MP0000015_abnormal_ear_pigmentation	1.21460042
53	MP0008877_abnormal_DNA_methylation	1.20744165
54	MP0009764_decreased_sensitivity_to	1.19384206
55	MP0005174_abnormal_tail_pigmentation	1.17124674
56	MP0003183_abnormal_peptide_metabolism	1.15852757
57	MP0005408_hypopigmentation	1.15338588
58	MP0009840_abnormal_foam_cell	1.13802961
59	MP0001800_abnormal_humoral_immune	1.13638357
60	MP0008872_abnormal_physiological_respon	1.13076699
61	MP0005636_abnormal_mineral_homeostasis	1.12518500
62	MP0003724_increased_susceptibility_to	1.12486376
63	MP0003868_abnormal_feces_composition	1.12074859
64	MP0005410_abnormal_fertilization	1.11389583
65	MP0001666_abnormal_nutrient_absorption	1.07494719
66	MP0010386_abnormal_urinary_bladder	1.06613812
67	MP0005645_abnormal_hypothalamus_physiol	1.04141983
68	MP0009763_increased_sensitivity_to	1.03635372
69	MP0000372_irregular_coat_pigmentation	1.03610555
70	MP0003075_altered_response_to	1.01263673
71	MP0006035_abnormal_mitochondrial_morpho	0.98812387
72	MP0001819_abnormal_immune_cell	0.98636278
73	MP0003303_peritoneal_inflammation	0.97996848
74	MP0002420_abnormal_adaptive_immunity	0.97587309
75	MP0000516_abnormal_urinary_system	0.94991228
76	MP0005367_renal/urinary_system_phenotyp	0.94991228
77	MP0002006_tumorigenesis	0.94651900
78	MP0005387_immune_system_phenotype	0.93914462
79	MP0001790_abnormal_immune_system	0.93914462
80	MP0001986_abnormal_taste_sensitivity	0.91729953
81	MP0005376_homeostasis/metabolism_phenot	0.90330136
82	MP0000689_abnormal_spleen_morphology	0.88217556
83	MP0002405_respiratory_system_inflammati	0.87075034
84	MP0002396_abnormal_hematopoietic_system	0.86639051
85	MP0000609_abnormal_liver_physiology	0.86521101
86	MP0000358_abnormal_cell_content/	0.85216805
87	MP0003718_maternal_effect	0.80579630
88	MP0005319_abnormal_enzyme/_coenzyme	0.80507994
89	MP0005167_abnormal_blood-brain_barrier	0.79579856
90	MP0001533_abnormal_skeleton_physiology	0.79462788
91	MP0010155_abnormal_intestine_physiology	0.78557179
92	MP0002876_abnormal_thyroid_physiology	0.77446119
93	MP0008873_increased_physiological_sensi	0.77335893
94	MP0008004_abnormal_stomach_pH	0.77030213
95	MP0002090_abnormal_vision	0.76957918
96	MP0000716_abnormal_immune_system	0.76836202
97	MP0002254_reproductive_system_inflammat	0.72933599
98	MP0001542_abnormal_bone_strength	0.72921905
99	MP0000639_abnormal_adrenal_gland	0.71244217
100	MP0002928_abnormal_bile_duct	0.71226530

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	3.64431794
2	Hepatic necrosis (HP:0002605)	3.43779063
3	Acute necrotizing encephalopathy (HP:0006965)	3.26921901
4	Hypothermia (HP:0002045)	3.23224323
5	Mitochondrial inheritance (HP:0001427)	3.22306043
6	Vacuolated lymphocytes (HP:0001922)	3.21408294
7	Renal cortical cysts (HP:0000803)	3.18219374
8	Increased CSF lactate (HP:0002490)	3.13527783
9	Acute encephalopathy (HP:0006846)	3.04337548
10	Petechiae (HP:0000967)	2.99900840
11	Progressive macrocephaly (HP:0004481)	2.98490681
12	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88418810
13	Acanthocytosis (HP:0001927)	2.78365572
14	Stomatitis (HP:0010280)	2.76851363
15	Thrombocytosis (HP:0001894)	2.63818768
16	Abnormality of liposaccharide metabolism (HP:0010968)	2.51202555
17	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.51202555
18	Abnormality of glycolipid metabolism (HP:0010969)	2.51202555
19	Generalized aminoaciduria (HP:0002909)	2.46291598
20	Lipid accumulation in hepatocytes (HP:0006561)	2.39760707
21	Gingival bleeding (HP:0000225)	2.39716455
22	Type I transferrin isoform profile (HP:0003642)	2.35808722
23	Prolonged neonatal jaundice (HP:0006579)	2.33716217
24	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.31930315
25	Renal Fanconi syndrome (HP:0001994)	2.28138813
26	Increased hepatocellular lipid droplets (HP:0006565)	2.27375406
27	3-Methylglutaconic aciduria (HP:0003535)	2.27253032
28	Abnormality of B cell number (HP:0010975)	2.26687810
29	Hypobetalipoproteinemia (HP:0003563)	2.21571403
30	Dysostosis multiplex (HP:0000943)	2.16685209
31	Respiratory failure (HP:0002878)	2.15658844
32	Abnormality of urine glucose concentration (HP:0011016)	2.15185583
33	Glycosuria (HP:0003076)	2.15185583
34	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.13925589
35	Abnormal protein N-linked glycosylation (HP:0012347)	2.13925589
36	Abnormal protein glycosylation (HP:0012346)	2.13925589
37	Abnormal glycosylation (HP:0012345)	2.13925589
38	CNS demyelination (HP:0007305)	2.13871800
39	Reduced antithrombin III activity (HP:0001976)	2.12610644
40	Spondylolisthesis (HP:0003302)	2.12423522
41	Retrobulbar optic neuritis (HP:0100654)	2.11970985
42	Optic neuritis (HP:0100653)	2.11970985
43	Exertional dyspnea (HP:0002875)	2.11871123
44	Acute hepatic failure (HP:0006554)	2.09632589
45	Abnormality of the wing of the ilium (HP:0011867)	2.09381842
46	Short middle phalanx of the 5th finger (HP:0004220)	2.09124560
47	Abnormality of the renal cortex (HP:0011035)	2.09098872
48	Entropion (HP:0000621)	2.08521554
49	Pulmonary infiltrates (HP:0002113)	2.07940401
50	Proximal tubulopathy (HP:0000114)	2.05372806
51	Methylmalonic acidemia (HP:0002912)	2.04858960
52	Beaking of vertebral bodies (HP:0004568)	2.03717442
53	Increased serum lactate (HP:0002151)	2.03257950
54	Prolonged partial thromboplastin time (HP:0003645)	2.02912170
55	Poikilocytosis (HP:0004447)	2.00894155
56	Abnormality of the prostate (HP:0008775)	2.00214988
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.00198575
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.00198575
59	Lactic acidosis (HP:0003128)	1.99798557
60	Cerebral edema (HP:0002181)	1.99679747
61	Pancreatic cysts (HP:0001737)	1.94264732
62	Congenital, generalized hypertrichosis (HP:0004540)	1.93313721
63	Albinism (HP:0001022)	1.92902782
64	Abnormality of the common coagulation pathway (HP:0010990)	1.91040811
65	Medial flaring of the eyebrow (HP:0010747)	1.90650961
66	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.88485681
67	Abnormality of dental color (HP:0011073)	1.85317322
68	Spontaneous abortion (HP:0005268)	1.84017535
69	Mucopolysacchariduria (HP:0008155)	1.81724062
70	Urinary glycosaminoglycan excretion (HP:0003541)	1.81724062
71	Epistaxis (HP:0000421)	1.81335386
72	Abnormality of glycolysis (HP:0004366)	1.81200779
73	Abnormality of polysaccharide metabolism (HP:0011012)	1.80969227
74	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.80969227
75	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.80969227
76	Thrombophlebitis (HP:0004418)	1.80655775
77	Abnormality of methionine metabolism (HP:0010901)	1.80499916
78	Abnormality of eosinophils (HP:0001879)	1.79895751
79	Autoimmune hemolytic anemia (HP:0001890)	1.79836093
80	IgG deficiency (HP:0004315)	1.79564639
81	Prolonged bleeding time (HP:0003010)	1.79288944
82	Polyneuropathy (HP:0001271)	1.79186954
83	Myositis (HP:0100614)	1.78890218
84	Abnormal gallbladder physiology (HP:0012438)	1.78776810
85	Cholecystitis (HP:0001082)	1.78776810
86	Thyroiditis (HP:0100646)	1.78772918
87	Eosinophilia (HP:0001880)	1.77939782
88	Abnormality of midbrain morphology (HP:0002418)	1.77283568
89	Molar tooth sign on MRI (HP:0002419)	1.77283568
90	Disproportionate short-trunk short stature (HP:0003521)	1.77121971
91	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.73157806
92	Type 2 muscle fiber atrophy (HP:0003554)	1.72677911
93	Fatigue (HP:0012378)	1.71805497
94	Flared iliac wings (HP:0002869)	1.69425501
95	Increased intramyocellular lipid droplets (HP:0012240)	1.69049499
96	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.68742429
97	Poikiloderma (HP:0001029)	1.68673866
98	Lethargy (HP:0001254)	1.68331285
99	Cutaneous melanoma (HP:0012056)	1.67939732
100	Chronic diarrhea (HP:0002028)	1.67400751

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.39988207
2	BMPR2	3.91302632
3	MST4	3.28042987
4	EIF2AK3	3.24282480
5	MAP3K12	2.49023897
6	FRK	2.47229330
7	TAOK3	2.27622772
8	NUAK1	2.24938614
9	ACVR1B	2.09883353
10	TXK	2.05372547
11	TEC	1.82680050
12	CAMKK2	1.81249775
13	PDK2	1.79739854
14	EIF2AK1	1.78879431
15	FLT3	1.76531208
16	AKT3	1.76387542
17	PIK3CG	1.74763426
18	CDK19	1.67185062
19	CDK8	1.62709883
20	MYLK	1.51326193
21	GRK7	1.49328887
22	ERBB3	1.44561965
23	SCYL2	1.34112034
24	WNK3	1.33324316
25	MAP3K14	1.32230568
26	IKBKB	1.29851731
27	PINK1	1.29058319
28	BMPR1B	1.22947497
29	TGFBR2	1.21851765
30	WNK4	1.19003294
31	STK39	1.18609199
32	KIT	1.17713153
33	BCKDK	1.08673517
34	ZAK	1.08345201
35	PBK	1.05144160
36	TRIM28	1.03844740
37	MATK	1.02847546
38	TRPM7	1.00842824
39	TYK2	1.00726324
40	STK3	1.00404188
41	ADRBK2	0.98283568
42	IRAK3	0.96220252
43	STK38L	0.95922370
44	STK24	0.93618625
45	BCR	0.92223755
46	TBK1	0.91492648
47	OXSR1	0.89590913
48	CSF1R	0.89085978
49	ILK	0.88998479
50	TLK1	0.87739702
51	NME2	0.87615739
52	PLK2	0.86844581
53	JAK3	0.79224287
54	NEK1	0.78028706
55	CCNB1	0.76874046
56	RIPK4	0.76846930
57	LYN	0.70657034
58	PLK3	0.68598605
59	PRKCQ	0.66153122
60	IGF1R	0.63486275
61	GRK1	0.63474810
62	PRKCE	0.63455891
63	INSRR	0.61237066
64	LCK	0.58244480
65	MAP2K6	0.57959729
66	ABL1	0.57272745
67	ERBB4	0.56862029
68	SIK3	0.54802239
69	MKNK1	0.51695815
70	ITK	0.50744845
71	MAPK13	0.50588697
72	EIF2AK2	0.49893485
73	MARK3	0.46786287
74	MUSK	0.46314758
75	VRK1	0.45993261
76	SYK	0.45581678
77	PKN1	0.45345888
78	PAK3	0.45168435
79	BRD4	0.45064801
80	FGFR3	0.44487309
81	EGFR	0.44389192
82	ABL2	0.41236966
83	CSNK2A1	0.39804837
84	ADRBK1	0.38242702
85	DDR2	0.38120209
86	GRK6	0.37245244
87	CSNK1G3	0.37152156
88	IKBKE	0.37068747
89	MAP2K3	0.36806637
90	PHKG1	0.36561827
91	PHKG2	0.36561827
92	JAK1	0.35357081
93	CLK1	0.34710125
94	CSNK2A2	0.34516169
95	IRAK4	0.32140811
96	INSR	0.31922774
97	DAPK3	0.31175936
98	BTK	0.30301230
99	TIE1	0.29707879
100	CSNK1G2	0.29040656

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.51570449
2	Asthma_Homo sapiens_hsa05310	3.47167225
3	Graft-versus-host disease_Homo sapiens_hsa05332	2.60427069
4	Allograft rejection_Homo sapiens_hsa05330	2.45091063
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.40550153
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.33365185
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.18878773
8	Rheumatoid arthritis_Homo sapiens_hsa05323	2.07530193
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03462706
10	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.95457806
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.90864244
12	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.86868517
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69082581
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65650407
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63749410
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.63002137
17	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.60447322
18	Sulfur metabolism_Homo sapiens_hsa00920	1.56304696
19	Fatty acid elongation_Homo sapiens_hsa00062	1.55956756
20	Proteasome_Homo sapiens_hsa03050	1.51822478
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.50898262
22	Glutathione metabolism_Homo sapiens_hsa00480	1.49970448
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46465554
24	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.45965512
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.44663542
26	Basal transcription factors_Homo sapiens_hsa03022	1.42123892
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41353042
28	Other glycan degradation_Homo sapiens_hsa00511	1.40855758
29	Parkinsons disease_Homo sapiens_hsa05012	1.35994691
30	Leishmaniasis_Homo sapiens_hsa05140	1.34642185
31	Complement and coagulation cascades_Homo sapiens_hsa04610	1.34510322
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27631678
33	Butanoate metabolism_Homo sapiens_hsa00650	1.26998341
34	Legionellosis_Homo sapiens_hsa05134	1.23640403
35	African trypanosomiasis_Homo sapiens_hsa05143	1.23094535
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.23077244
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20645975
38	RNA polymerase_Homo sapiens_hsa03020	1.20351281
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19846072
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.15624149
41	Peroxisome_Homo sapiens_hsa04146	1.15547833
42	Propanoate metabolism_Homo sapiens_hsa00640	1.14765440
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14107195
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13345930
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10573431
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05366850
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.05257445
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04995282
49	Homologous recombination_Homo sapiens_hsa03440	1.03399401
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01683262
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.98787294
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.97446969
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97076299
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96488713
55	Fatty acid degradation_Homo sapiens_hsa00071	0.96074376
56	Ribosome_Homo sapiens_hsa03010	0.95141580
57	Regulation of autophagy_Homo sapiens_hsa04140	0.94620996
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.91295878
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90835007
60	Viral myocarditis_Homo sapiens_hsa05416	0.90651068
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.89448968
62	Tuberculosis_Homo sapiens_hsa05152	0.89400857
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.87481766
64	RNA degradation_Homo sapiens_hsa03018	0.85255454
65	Shigellosis_Homo sapiens_hsa05131	0.85004395
66	Lysosome_Homo sapiens_hsa04142	0.83565904
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.82774285
68	Malaria_Homo sapiens_hsa05144	0.81916346
69	Pertussis_Homo sapiens_hsa05133	0.80247782
70	Alzheimers disease_Homo sapiens_hsa05010	0.79406887
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78975483
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78725737
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.78601255
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77175554
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.76596660
76	Phagosome_Homo sapiens_hsa04145	0.76034423
77	Herpes simplex infection_Homo sapiens_hsa05168	0.74274413
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71180290
79	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.69629195
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68843119
81	One carbon pool by folate_Homo sapiens_hsa00670	0.68796751
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.63652972
83	Retinol metabolism_Homo sapiens_hsa00830	0.62511782
84	Salmonella infection_Homo sapiens_hsa05132	0.62217729
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59307851
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59261921
87	Huntingtons disease_Homo sapiens_hsa05016	0.57226070
88	Phototransduction_Homo sapiens_hsa04744	0.53109000
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51254020
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.50790853
91	Purine metabolism_Homo sapiens_hsa00230	0.49873584
92	Metabolic pathways_Homo sapiens_hsa01100	0.47888285
93	Influenza A_Homo sapiens_hsa05164	0.47876103
94	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46488933
95	Galactose metabolism_Homo sapiens_hsa00052	0.46412309
96	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46242943
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45562216
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37549600
99	Toxoplasmosis_Homo sapiens_hsa05145	0.37141242
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31897949

FRG1CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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