FRG1DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.74297489
2cytidine metabolic process (GO:0046087)4.41812378
3cytidine catabolic process (GO:0006216)4.41812378
4cytidine deamination (GO:0009972)4.41812378
5piRNA metabolic process (GO:0034587)4.19675841
6positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.07676447
7pyrimidine ribonucleoside catabolic process (GO:0046133)3.98567601
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89018643
9regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.67609135
10rRNA modification (GO:0000154)3.52763748
11respiratory chain complex IV assembly (GO:0008535)3.49664559
12response to pheromone (GO:0019236)3.37508901
13synapsis (GO:0007129)3.32681180
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31351974
15phosphorylated carbohydrate dephosphorylation (GO:0046838)3.29160206
16inositol phosphate dephosphorylation (GO:0046855)3.29160206
17inositol phosphate catabolic process (GO:0071545)3.28109404
18positive regulation of defense response to virus by host (GO:0002230)3.22292858
19mannosylation (GO:0097502)3.22277013
20rRNA methylation (GO:0031167)3.22082666
21male meiosis I (GO:0007141)3.21681116
22protein complex biogenesis (GO:0070271)3.20882895
23cytochrome complex assembly (GO:0017004)3.19522648
24cellular ketone body metabolic process (GO:0046950)3.18718592
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.07324619
26NADH dehydrogenase complex assembly (GO:0010257)3.07324619
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07324619
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07207847
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06037580
30ATP synthesis coupled proton transport (GO:0015986)3.06037580
31ketone body metabolic process (GO:1902224)3.06037342
32DNA methylation involved in gamete generation (GO:0043046)3.05428349
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04149303
34rRNA catabolic process (GO:0016075)3.02353361
35platelet dense granule organization (GO:0060155)3.01761026
36proteasome assembly (GO:0043248)2.94245788
37respiratory electron transport chain (GO:0022904)2.94146862
38actin nucleation (GO:0045010)2.93909240
39electron transport chain (GO:0022900)2.92212885
40regulation of meiosis I (GO:0060631)2.92111472
41mitochondrial respiratory chain complex assembly (GO:0033108)2.91961550
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88435989
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88435989
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86633411
45ubiquinone biosynthetic process (GO:0006744)2.84646732
46DNA double-strand break processing (GO:0000729)2.74533527
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72394880
48response to interferon-beta (GO:0035456)2.70759842
49regulation of memory T cell differentiation (GO:0043380)2.68111969
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65148075
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64571195
52regulation of B cell apoptotic process (GO:0002902)2.64321279
53S-adenosylmethionine metabolic process (GO:0046500)2.62674028
54oxidative phosphorylation (GO:0006119)2.59232762
55deoxyribonucleotide catabolic process (GO:0009264)2.58984064
56water-soluble vitamin biosynthetic process (GO:0042364)2.58360069
57deoxyribose phosphate catabolic process (GO:0046386)2.57517256
58base-excision repair, AP site formation (GO:0006285)2.57477818
59negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56475692
60detection of light stimulus involved in sensory perception (GO:0050962)2.55200752
61detection of light stimulus involved in visual perception (GO:0050908)2.55200752
62male meiosis (GO:0007140)2.53517179
63autophagic vacuole fusion (GO:0000046)2.52383765
64polyol catabolic process (GO:0046174)2.52172537
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51426064
66aggressive behavior (GO:0002118)2.51307123
67purine deoxyribonucleotide catabolic process (GO:0009155)2.51112172
68deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.51006421
69dopamine transport (GO:0015872)2.49740491
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49449247
71positive regulation of histone H3-K4 methylation (GO:0051571)2.49277267
72positive regulation of alpha-beta T cell proliferation (GO:0046641)2.48716926
73adenosine metabolic process (GO:0046085)2.46491301
74pseudouridine synthesis (GO:0001522)2.46259204
75regulation of mitochondrial translation (GO:0070129)2.45428684
76positive regulation of interleukin-17 production (GO:0032740)2.44660673
77meiosis I (GO:0007127)2.44247023
78pyrimidine nucleotide catabolic process (GO:0006244)2.43169294
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41189140
80aldehyde catabolic process (GO:0046185)2.41053530
81anterograde synaptic vesicle transport (GO:0048490)2.40960818
82purine nucleotide salvage (GO:0032261)2.40941206
83cellular response to interferon-beta (GO:0035458)2.39096187
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38921255
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38745392
86purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.38154487
87maturation of 5.8S rRNA (GO:0000460)2.37642597
88protein-cofactor linkage (GO:0018065)2.37024032
89axoneme assembly (GO:0035082)2.36413879
90preassembly of GPI anchor in ER membrane (GO:0016254)2.36305355
91organic cation transport (GO:0015695)2.35426038
92regulation of germinal center formation (GO:0002634)2.34747318
93pyrimidine nucleoside catabolic process (GO:0046135)2.34298728
94short-chain fatty acid metabolic process (GO:0046459)2.33463965
95purine deoxyribonucleotide metabolic process (GO:0009151)2.33456357
96regulation of B cell receptor signaling pathway (GO:0050855)2.32845233
97quinone biosynthetic process (GO:1901663)2.31761425
98terpenoid biosynthetic process (GO:0016114)2.30694493
99negative regulation of acute inflammatory response (GO:0002674)2.30077471
100ubiquinone metabolic process (GO:0006743)2.29791261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.60693003
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.58665714
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31610789
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.16118535
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06742002
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93555766
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.76412988
8VDR_23849224_ChIP-Seq_CD4+_Human2.63121668
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52090036
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51672596
11VDR_22108803_ChIP-Seq_LS180_Human2.44308960
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38563902
13IGF1R_20145208_ChIP-Seq_DFB_Human2.36072219
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.30620074
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29418651
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.28025839
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.19814079
18FOXP3_21729870_ChIP-Seq_TREG_Human2.09588838
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04253131
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87136230
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78940907
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74422152
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73823018
24ELK1_19687146_ChIP-ChIP_HELA_Human1.71912235
25TP53_22573176_ChIP-Seq_HFKS_Human1.71494799
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69720456
27SCL_19346495_ChIP-Seq_HPC-7_Human1.68158270
28GATA3_26560356_Chip-Seq_TH2_Human1.64111492
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62937100
30MYB_26560356_Chip-Seq_TH2_Human1.62686004
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55856874
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.54413303
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53294303
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53066315
35GATA1_22025678_ChIP-Seq_K562_Human1.51750014
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50840227
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49860316
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49842056
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47474008
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.45510810
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.43751198
42AR_20517297_ChIP-Seq_VCAP_Human1.43349930
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42848671
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.41372513
45MYC_18940864_ChIP-ChIP_HL60_Human1.39773569
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.39149882
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39149882
48CIITA_25753668_ChIP-Seq_RAJI_Human1.38534604
49ER_23166858_ChIP-Seq_MCF-7_Human1.33431989
50SPI1_23547873_ChIP-Seq_NB4_Human1.31270843
51EWS_26573619_Chip-Seq_HEK293_Human1.30561216
52GATA3_27048872_Chip-Seq_THYMUS_Human1.28203182
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27408278
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26457651
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26170360
56SOX2_19829295_ChIP-Seq_ESCs_Human1.22661098
57NANOG_19829295_ChIP-Seq_ESCs_Human1.22661098
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18503941
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17607244
60TAF15_26573619_Chip-Seq_HEK293_Human1.17388589
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16667012
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16317697
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16260579
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16257971
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14934149
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.14062832
67NCOR_22424771_ChIP-Seq_293T_Human1.13809903
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12497144
69FUS_26573619_Chip-Seq_HEK293_Human1.11843561
70IRF1_19129219_ChIP-ChIP_H3396_Human1.11370609
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09311794
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08552727
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.08463674
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08260064
75RUNX_20019798_ChIP-Seq_JUKART_Human1.06524671
76ERG_20517297_ChIP-Seq_VCAP_Human1.06226093
77GATA3_26560356_Chip-Seq_TH1_Human1.06215727
78DCP1A_22483619_ChIP-Seq_HELA_Human1.05682894
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05435028
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04819425
81MYB_26560356_Chip-Seq_TH1_Human1.03399220
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03002855
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02299073
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01857881
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.01831553
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01449590
87GABP_19822575_ChIP-Seq_HepG2_Human1.00746607
88NANOG_20526341_ChIP-Seq_ESCs_Human1.00283148
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00210995
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00038045
91TAF2_19829295_ChIP-Seq_ESCs_Human0.99655359
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99365908
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99077742
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97316338
95RBPJ_21746931_ChIP-Seq_IB4_Human0.96366670
96MYC_19829295_ChIP-Seq_ESCs_Human0.96051631
97HTT_18923047_ChIP-ChIP_STHdh_Human0.94461417
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.93544014
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93106176
100PHF8_20622853_ChIP-Seq_HELA_Human0.91041963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.71646169
2MP0000372_irregular_coat_pigmentation3.62488890
3MP0003806_abnormal_nucleotide_metabolis2.85788892
4MP0008877_abnormal_DNA_methylation2.77226628
5MP0005671_abnormal_response_to2.59899596
6MP0001835_abnormal_antigen_presentation2.54368148
7MP0005646_abnormal_pituitary_gland2.38639118
8MP0005645_abnormal_hypothalamus_physiol2.37516009
9MP0005075_abnormal_melanosome_morpholog2.27729105
10MP0006072_abnormal_retinal_apoptosis2.21210163
11MP0002837_dystrophic_cardiac_calcinosis2.04330356
12MP0008058_abnormal_DNA_repair1.99134041
13MP0002876_abnormal_thyroid_physiology1.95052514
14MP0006036_abnormal_mitochondrial_physio1.83600652
15MP0003195_calcinosis1.75965195
16MP0002102_abnormal_ear_morphology1.70471717
17MP0003786_premature_aging1.69269873
18MP0002638_abnormal_pupillary_reflex1.69125694
19MP0002148_abnormal_hypersensitivity_rea1.66909842
20MP0001764_abnormal_homeostasis1.62169677
21MP0009785_altered_susceptibility_to1.58128771
22MP0002396_abnormal_hematopoietic_system1.57197184
23MP0001800_abnormal_humoral_immune1.57191864
24MP0005000_abnormal_immune_tolerance1.54287927
25MP0005551_abnormal_eye_electrophysiolog1.50380369
26MP0008875_abnormal_xenobiotic_pharmacok1.49559615
27MP0005379_endocrine/exocrine_gland_phen1.48501324
28MP0003763_abnormal_thymus_physiology1.47906918
29MP0002166_altered_tumor_susceptibility1.46384906
30MP0005174_abnormal_tail_pigmentation1.45997938
31MP0002723_abnormal_immune_serum1.45820747
32MP0008872_abnormal_physiological_respon1.45381467
33MP0005253_abnormal_eye_physiology1.43435296
34MP0005332_abnormal_amino_acid1.40471599
35MP0000015_abnormal_ear_pigmentation1.37635580
36MP0002163_abnormal_gland_morphology1.36065965
37MP0008995_early_reproductive_senescence1.34965391
38MP0003646_muscle_fatigue1.34694176
39MP0003718_maternal_effect1.31897435
40MP0003656_abnormal_erythrocyte_physiolo1.31228457
41MP0005636_abnormal_mineral_homeostasis1.29969724
42MP0002693_abnormal_pancreas_physiology1.29717964
43MP0005464_abnormal_platelet_physiology1.28626930
44MP0005084_abnormal_gallbladder_morpholo1.27523759
45MP0002452_abnormal_antigen_presenting1.25543582
46MP0002398_abnormal_bone_marrow1.25392879
47MP0002420_abnormal_adaptive_immunity1.24927364
48MP0001819_abnormal_immune_cell1.23138027
49MP0001986_abnormal_taste_sensitivity1.22743763
50MP0000013_abnormal_adipose_tissue1.20774060
51MP0005389_reproductive_system_phenotype1.18803768
52MP0002095_abnormal_skin_pigmentation1.18790749
53MP0001873_stomach_inflammation1.16646119
54MP0001545_abnormal_hematopoietic_system1.16589800
55MP0005397_hematopoietic_system_phenotyp1.16589800
56MP0001905_abnormal_dopamine_level1.14348377
57MP0000689_abnormal_spleen_morphology1.13920073
58MP0001661_extended_life_span1.11971534
59MP0002006_tumorigenesis1.11844366
60MP0004142_abnormal_muscle_tone1.11709280
61MP0000685_abnormal_immune_system1.10919480
62MP0001501_abnormal_sleep_pattern1.10709971
63MP0004043_abnormal_pH_regulation1.08340071
64MP0000716_abnormal_immune_system1.07645485
65MP0004145_abnormal_muscle_electrophysio1.06605328
66MP0005410_abnormal_fertilization1.06419227
67MP0001929_abnormal_gametogenesis1.04909471
68MP0002160_abnormal_reproductive_system1.03650093
69MP0005387_immune_system_phenotype1.03640394
70MP0001790_abnormal_immune_system1.03640394
71MP0000465_gastrointestinal_hemorrhage1.02799118
72MP0009697_abnormal_copulation1.00553153
73MP0005025_abnormal_response_to0.99263131
74MP0000516_abnormal_urinary_system0.97453852
75MP0005367_renal/urinary_system_phenotyp0.97453852
76MP0001968_abnormal_touch/_nociception0.96843163
77MP0009333_abnormal_splenocyte_physiolog0.95365118
78MP0002722_abnormal_immune_system0.95149591
79MP0003252_abnormal_bile_duct0.94827395
80MP0001919_abnormal_reproductive_system0.94308821
81MP0002429_abnormal_blood_cell0.90809446
82MP0003724_increased_susceptibility_to0.90657957
83MP0005408_hypopigmentation0.89690778
84MP0001765_abnormal_ion_homeostasis0.89557636
85MP0002909_abnormal_adrenal_gland0.89040907
86MP0008469_abnormal_protein_level0.88707220
87MP0009643_abnormal_urine_homeostasis0.88298545
88MP0005220_abnormal_exocrine_pancreas0.88235742
89MP0003787_abnormal_imprinting0.87961684
90MP0003186_abnormal_redox_activity0.86043267
91MP0006035_abnormal_mitochondrial_morpho0.85767541
92MP0001845_abnormal_inflammatory_respons0.84140841
93MP0002405_respiratory_system_inflammati0.83456882
94MP0000703_abnormal_thymus_morphology0.81868662
95MP0006276_abnormal_autonomic_nervous0.81023498
96MP0001984_abnormal_olfaction0.78985577
97MP0001853_heart_inflammation0.77251057
98MP0010155_abnormal_intestine_physiology0.76906915
99MP0009046_muscle_twitch0.76828278
100MP0002419_abnormal_innate_immunity0.74957160

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)3.74192868
2Renal Fanconi syndrome (HP:0001994)3.72325227
3Hepatocellular necrosis (HP:0001404)3.67067747
4Hepatic necrosis (HP:0002605)3.62609801
5Acute necrotizing encephalopathy (HP:0006965)3.41106849
6Increased CSF lactate (HP:0002490)3.40203750
7Lipid accumulation in hepatocytes (HP:0006561)3.33999143
8Increased hepatocellular lipid droplets (HP:0006565)3.26292604
9Severe combined immunodeficiency (HP:0004430)3.21633002
10Progressive macrocephaly (HP:0004481)3.18514217
11Abnormal mitochondria in muscle tissue (HP:0008316)3.10978780
12Acute encephalopathy (HP:0006846)3.04917199
13Congenital stationary night blindness (HP:0007642)3.04351823
14Panhypogammaglobulinemia (HP:0003139)2.84661415
15Agammaglobulinemia (HP:0004432)2.82715136
16Thyroiditis (HP:0100646)2.80610001
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.78750234
18Ketoacidosis (HP:0001993)2.72373344
19Increased intramyocellular lipid droplets (HP:0012240)2.70850447
203-Methylglutaconic aciduria (HP:0003535)2.70110557
21Generalized aminoaciduria (HP:0002909)2.68727509
22Renal cortical cysts (HP:0000803)2.67962843
23Abnormality of B cell number (HP:0010975)2.66463387
24IgG deficiency (HP:0004315)2.61702637
25Abnormal rod and cone electroretinograms (HP:0008323)2.58981802
26Elevated erythrocyte sedimentation rate (HP:0003565)2.55988306
27Attenuation of retinal blood vessels (HP:0007843)2.53269325
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52278141
29Abnormality of the prostate (HP:0008775)2.50887898
30Type II lissencephaly (HP:0007260)2.50626034
31Increased muscle lipid content (HP:0009058)2.49216282
32Hypothermia (HP:0002045)2.47991031
33Chronic mucocutaneous candidiasis (HP:0002728)2.45920786
34Recurrent cutaneous fungal infections (HP:0011370)2.45920786
35Abnormal protein N-linked glycosylation (HP:0012347)2.42238788
36Abnormal protein glycosylation (HP:0012346)2.42238788
37Abnormal glycosylation (HP:0012345)2.42238788
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42238788
39Combined immunodeficiency (HP:0005387)2.40601221
40Methylmalonic acidemia (HP:0002912)2.38945422
41Glycosuria (HP:0003076)2.38814492
42Abnormality of urine glucose concentration (HP:0011016)2.38814492
43Abnormality of renal resorption (HP:0011038)2.37652574
44Increased serum lactate (HP:0002151)2.36142634
45Type I transferrin isoform profile (HP:0003642)2.35766713
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34421777
47Exertional dyspnea (HP:0002875)2.34212633
48Hypoproteinemia (HP:0003075)2.34077913
49Petechiae (HP:0000967)2.33953234
50Progressive microcephaly (HP:0000253)2.33664638
51Stomatitis (HP:0010280)2.33040982
52Abnormality of T cell physiology (HP:0011840)2.30433645
53Lactic acidosis (HP:0003128)2.28804768
54Optic disc pallor (HP:0000543)2.23972134
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23666010
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23666010
57Hyperthyroidism (HP:0000836)2.22828397
58Abnormal drinking behavior (HP:0030082)2.19264996
59Polydipsia (HP:0001959)2.19264996
60Abnormality of T cells (HP:0002843)2.17871727
61B lymphocytopenia (HP:0010976)2.14625889
62Ketosis (HP:0001946)2.13536584
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12073457
64Cerebral edema (HP:0002181)2.10947787
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.08953607
66Abnormality of eosinophils (HP:0001879)2.08018134
67Pancreatic cysts (HP:0001737)2.07972091
68Abnormality of the renal cortex (HP:0011035)2.06979316
69Respiratory failure (HP:0002878)2.06548575
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06330499
71Dicarboxylic aciduria (HP:0003215)2.06330499
72Hypoplasia of the fovea (HP:0007750)1.98258992
73Aplasia/Hypoplasia of the fovea (HP:0008060)1.98258992
74Recurrent fungal infections (HP:0002841)1.96389239
75Aplasia/hypoplasia of the uterus (HP:0008684)1.95671170
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95352667
77Methylmalonic aciduria (HP:0012120)1.92668879
78Lethargy (HP:0001254)1.92579406
79Abnormality of T cell number (HP:0011839)1.92433249
80Cutaneous melanoma (HP:0012056)1.92213453
81Aplastic anemia (HP:0001915)1.91907870
82Abnormality of the fovea (HP:0000493)1.90112752
83Decreased central vision (HP:0007663)1.88995889
84Meningitis (HP:0001287)1.87417501
85Chronic obstructive pulmonary disease (HP:0006510)1.87239830
86Obstructive lung disease (HP:0006536)1.87239830
87Abnormality of macular pigmentation (HP:0008002)1.86592412
88CNS demyelination (HP:0007305)1.84831834
89Medial flaring of the eyebrow (HP:0010747)1.84515667
90Abolished electroretinogram (ERG) (HP:0000550)1.83419722
91Autoimmune hemolytic anemia (HP:0001890)1.83242686
92Constricted visual fields (HP:0001133)1.81649335
93Congenital, generalized hypertrichosis (HP:0004540)1.81105920
94Tetany (HP:0001281)1.80314158
95Pulmonary infiltrates (HP:0002113)1.80169229
96Abnormality of midbrain morphology (HP:0002418)1.79327408
97Molar tooth sign on MRI (HP:0002419)1.79327408
98Hypoplasia of the uterus (HP:0000013)1.77130479
99Pancreatic fibrosis (HP:0100732)1.76717824
100Abnormality of vitamin B metabolism (HP:0004340)1.76649489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.97854049
2TXK3.50734797
3MAP4K23.43465246
4TAOK33.26426099
5BMPR22.85402259
6EIF2AK32.41904640
7ADRBK22.23306376
8NUAK12.22116265
9ZAK2.19830182
10KIT2.08306708
11TESK22.04043154
12KDR1.94199807
13TLK11.83868072
14VRK21.79500082
15GRK11.70595194
16MAP4K11.68709427
17FLT31.68604673
18TEC1.65335192
19BMPR1B1.55639704
20MST41.54938633
21PINK11.49769766
22IKBKB1.49346834
23SCYL21.41435762
24BCKDK1.38347923
25EIF2AK11.32927473
26RIPK41.31646346
27WNK31.29138644
28SYK1.28072129
29ITK1.25786403
30WNK41.25184190
31OXSR11.24350368
32MAP3K121.16139806
33CSF1R1.15208712
34IKBKE1.14641200
35MARK31.06702104
36CCNB11.05673070
37MAPK131.05122674
38PHKG11.03863761
39PHKG21.03863761
40VRK11.02635329
41GRK60.99947521
42INSRR0.98029893
43TNK20.95911258
44STK390.95317604
45MUSK0.95169923
46BTK0.94696384
47EIF2AK20.93952993
48MATK0.92948253
49ERBB30.92231073
50MAP2K60.85897885
51PLK20.84028735
52PRKG20.82097629
53CSNK1G30.82089295
54PRKCQ0.80055352
55LCK0.77370664
56LYN0.75379086
57FES0.75133392
58PIK3CG0.73294561
59STK30.68273730
60TRPM70.67857468
61DAPK10.67049305
62MAP2K20.66848909
63PRKCE0.64867992
64TAF10.64802295
65STK160.64564357
66CSNK1G20.63578567
67PIM20.62979727
68PLK40.61051628
69GRK70.60783705
70DAPK20.60594651
71TBK10.60489669
72MAP3K140.60419839
73JAK30.58763033
74CSNK1G10.58027336
75PASK0.56851561
76STK240.52701514
77PRKCI0.51390698
78PIM10.51230287
79ADRBK10.48382978
80RPS6KA50.46721811
81PDK20.46599362
82ABL10.46262665
83ZAP700.44830689
84IGF1R0.44654556
85ATR0.43894115
86CLK10.43160728
87CSNK2A20.42999713
88HCK0.41899795
89PLK30.38594414
90PRKACA0.38398396
91ATM0.38082872
92NTRK30.36758044
93SRPK10.36694976
94RAF10.35421534
95PRKCA0.34148910
96MAPK110.33377992
97PKN10.31964525
98STK38L0.29464858
99EGFR0.29249037
100TRIM280.28647234

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.03292233
2Oxidative phosphorylation_Homo sapiens_hsa001903.03076674
3Asthma_Homo sapiens_hsa053102.72224027
4Type I diabetes mellitus_Homo sapiens_hsa049402.70678904
5Proteasome_Homo sapiens_hsa030502.70123270
6Protein export_Homo sapiens_hsa030602.66167958
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.61005730
8Parkinsons disease_Homo sapiens_hsa050122.50764819
9Allograft rejection_Homo sapiens_hsa053302.39331555
10Autoimmune thyroid disease_Homo sapiens_hsa053202.35603916
11Graft-versus-host disease_Homo sapiens_hsa053322.27704213
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.27444839
13Homologous recombination_Homo sapiens_hsa034402.00916651
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90756962
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82196531
16Butanoate metabolism_Homo sapiens_hsa006501.76985283
17One carbon pool by folate_Homo sapiens_hsa006701.72770822
18Non-homologous end-joining_Homo sapiens_hsa034501.72143687
19Sulfur metabolism_Homo sapiens_hsa009201.69395093
20RNA polymerase_Homo sapiens_hsa030201.64264629
21Basal transcription factors_Homo sapiens_hsa030221.62772498
22Phototransduction_Homo sapiens_hsa047441.60163314
23Rheumatoid arthritis_Homo sapiens_hsa053231.57520810
24Selenocompound metabolism_Homo sapiens_hsa004501.51674340
25Alzheimers disease_Homo sapiens_hsa050101.51064925
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44477758
27Fanconi anemia pathway_Homo sapiens_hsa034601.38712856
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36698229
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36247027
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36028330
31RNA degradation_Homo sapiens_hsa030181.35715583
32Antigen processing and presentation_Homo sapiens_hsa046121.34673832
33Huntingtons disease_Homo sapiens_hsa050161.31883905
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22510786
35Linoleic acid metabolism_Homo sapiens_hsa005911.18837313
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17625833
37Peroxisome_Homo sapiens_hsa041461.16185348
38Nucleotide excision repair_Homo sapiens_hsa034201.13420149
39Olfactory transduction_Homo sapiens_hsa047401.10880523
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09522091
41Hematopoietic cell lineage_Homo sapiens_hsa046401.08919954
42Fatty acid elongation_Homo sapiens_hsa000621.08374907
43Ribosome_Homo sapiens_hsa030101.08130855
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04418623
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04313249
46Collecting duct acid secretion_Homo sapiens_hsa049661.02729613
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02078079
48Pyrimidine metabolism_Homo sapiens_hsa002400.98416730
49Propanoate metabolism_Homo sapiens_hsa006400.97285343
50Purine metabolism_Homo sapiens_hsa002300.96374766
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95020650
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90998918
53Mismatch repair_Homo sapiens_hsa034300.90691452
54Ether lipid metabolism_Homo sapiens_hsa005650.89420852
55Regulation of autophagy_Homo sapiens_hsa041400.82421449
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81747574
57Nitrogen metabolism_Homo sapiens_hsa009100.80372059
58Folate biosynthesis_Homo sapiens_hsa007900.80064101
59Chemical carcinogenesis_Homo sapiens_hsa052040.78671207
60Base excision repair_Homo sapiens_hsa034100.76250951
61Cardiac muscle contraction_Homo sapiens_hsa042600.75969367
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72646276
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69897559
64Metabolic pathways_Homo sapiens_hsa011000.68805856
65Herpes simplex infection_Homo sapiens_hsa051680.66919240
66Tryptophan metabolism_Homo sapiens_hsa003800.64964876
67Arachidonic acid metabolism_Homo sapiens_hsa005900.64778920
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63689849
69Leishmaniasis_Homo sapiens_hsa051400.60678357
70DNA replication_Homo sapiens_hsa030300.60177179
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.59699293
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59436009
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57390433
74Retinol metabolism_Homo sapiens_hsa008300.53756493
75Viral myocarditis_Homo sapiens_hsa054160.52687991
76Caffeine metabolism_Homo sapiens_hsa002320.52091630
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.51137324
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50791529
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49499821
80RNA transport_Homo sapiens_hsa030130.46739692
81Staphylococcus aureus infection_Homo sapiens_hsa051500.45762328
82Glutathione metabolism_Homo sapiens_hsa004800.44878607
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44702919
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43903055
85Legionellosis_Homo sapiens_hsa051340.41701173
86Tyrosine metabolism_Homo sapiens_hsa003500.41391892
87ABC transporters_Homo sapiens_hsa020100.41227092
88Spliceosome_Homo sapiens_hsa030400.41102527
89Fatty acid metabolism_Homo sapiens_hsa012120.41055413
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.40772034
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40322114
92N-Glycan biosynthesis_Homo sapiens_hsa005100.37306236
93Insulin secretion_Homo sapiens_hsa049110.36428569
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.36287038
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36106120
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.36036435
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34904830
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30755072
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30743440
100Measles_Homo sapiens_hsa051620.30096358

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