ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein complex biogenesis (GO:0070271)	4.42395032
2	DNA deamination (GO:0045006)	4.35533440
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.24243953
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.24243953
5	NADH dehydrogenase complex assembly (GO:0010257)	4.24243953
6	behavioral response to nicotine (GO:0035095)	4.04187410
7	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00742367
8	respiratory chain complex IV assembly (GO:0008535)	3.87037843
9	platelet dense granule organization (GO:0060155)	3.75653141
10	cytochrome complex assembly (GO:0017004)	3.67133538
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.64901489
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.63220522
13	response to pheromone (GO:0019236)	3.60219599
14	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.58260999
15	piRNA metabolic process (GO:0034587)	3.53117441
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.52948711
17	ATP synthesis coupled proton transport (GO:0015986)	3.46629878
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.46629878
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.42153580
20	mannosylation (GO:0097502)	3.38259038
21	protein-cofactor linkage (GO:0018065)	3.33781301
22	regulation of cilium movement (GO:0003352)	3.24091878
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.22408592
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.20464053
25	seminiferous tubule development (GO:0072520)	3.07945885
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.06874453
27	detection of light stimulus involved in visual perception (GO:0050908)	3.06874453
28	fucose catabolic process (GO:0019317)	3.05733141
29	L-fucose metabolic process (GO:0042354)	3.05733141
30	L-fucose catabolic process (GO:0042355)	3.05733141
31	electron transport chain (GO:0022900)	3.02130092
32	respiratory electron transport chain (GO:0022904)	3.01167087
33	protein K11-linked deubiquitination (GO:0035871)	3.00009979
34	nonmotile primary cilium assembly (GO:0035058)	2.99339502
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98328843
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98328843
37	indolalkylamine metabolic process (GO:0006586)	2.97239924
38	epithelial cilium movement (GO:0003351)	2.96517448
39	axoneme assembly (GO:0035082)	2.95561793
40	protein polyglutamylation (GO:0018095)	2.94623322
41	negative regulation of telomere maintenance (GO:0032205)	2.90836363
42	tryptophan catabolic process (GO:0006569)	2.88010454
43	indole-containing compound catabolic process (GO:0042436)	2.88010454
44	indolalkylamine catabolic process (GO:0046218)	2.88010454
45	neural tube formation (GO:0001841)	2.87464743
46	GPI anchor metabolic process (GO:0006505)	2.79454063
47	dopamine transport (GO:0015872)	2.78746611
48	DNA methylation involved in gamete generation (GO:0043046)	2.78730949
49	centriole replication (GO:0007099)	2.78703026
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76123820
51	negative regulation of mast cell activation (GO:0033004)	2.75647630
52	cellular ketone body metabolic process (GO:0046950)	2.73938743
53	base-excision repair, AP site formation (GO:0006285)	2.73060383
54	regulation of meiosis I (GO:0060631)	2.68905422
55	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.67504612
56	DNA double-strand break processing (GO:0000729)	2.66901289
57	male meiosis (GO:0007140)	2.64831121
58	recombinational repair (GO:0000725)	2.63742761
59	positive regulation of protein homodimerization activity (GO:0090073)	2.63275393
60	tryptophan metabolic process (GO:0006568)	2.62217868
61	double-strand break repair via homologous recombination (GO:0000724)	2.62155004
62	male meiosis I (GO:0007141)	2.60257356
63	adenosine metabolic process (GO:0046085)	2.59862799
64	chaperone-mediated protein transport (GO:0072321)	2.58558711
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58155364
66	replication fork processing (GO:0031297)	2.57767118
67	hydrogen ion transmembrane transport (GO:1902600)	2.57272402
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.56476861
69	inositol phosphate catabolic process (GO:0071545)	2.54880923
70	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.52421256
71	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.52253406
72	proton transport (GO:0015992)	2.51733357
73	ketone body metabolic process (GO:1902224)	2.51400841
74	photoreceptor cell maintenance (GO:0045494)	2.50862922
75	GPI anchor biosynthetic process (GO:0006506)	2.50784623
76	protein localization to cilium (GO:0061512)	2.50777171
77	rRNA modification (GO:0000154)	2.50404287
78	hydrogen transport (GO:0006818)	2.48772560
79	peptidyl-histidine modification (GO:0018202)	2.48665340
80	ubiquinone biosynthetic process (GO:0006744)	2.47740526
81	cilium morphogenesis (GO:0060271)	2.44939644
82	C-terminal protein lipidation (GO:0006501)	2.44450893
83	kynurenine metabolic process (GO:0070189)	2.42704827
84	positive regulation of prostaglandin secretion (GO:0032308)	2.40572282
85	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.39084259
86	retinal cone cell development (GO:0046549)	2.37282373
87	proteasome assembly (GO:0043248)	2.36122330
88	regulation of action potential (GO:0098900)	2.35563432
89	photoreceptor cell development (GO:0042461)	2.35529233
90	cilium movement (GO:0003341)	2.35397890
91	negative regulation of response to food (GO:0032096)	2.34651790
92	negative regulation of appetite (GO:0032099)	2.34651790
93	protein deneddylation (GO:0000338)	2.34508075
94	protein K6-linked ubiquitination (GO:0085020)	2.33970887
95	tRNA processing (GO:0008033)	2.33813171
96	regulation of hexokinase activity (GO:1903299)	2.33761729
97	regulation of glucokinase activity (GO:0033131)	2.33761729
98	neuronal action potential (GO:0019228)	2.33747660
99	synapsis (GO:0007129)	2.33103033
100	cilium organization (GO:0044782)	2.32915408

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.65988559
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33244061
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.28820804
4	VDR_22108803_ChIP-Seq_LS180_Human	3.19893795
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.86651981
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58064322
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.57588006
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53807873
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40498563
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36324189
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29274462
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28146068
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.24962646
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.18258023
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14687312
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07765860
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04337933
18	EWS_26573619_Chip-Seq_HEK293_Human	2.03049129
19	FUS_26573619_Chip-Seq_HEK293_Human	1.96727268
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.92712558
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92163540
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92068866
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.89201929
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.88912996
25	P300_19829295_ChIP-Seq_ESCs_Human	1.86979378
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.81400614
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69129436
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68114180
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65482504
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.59639261
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55639864
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.53643446
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53643446
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51723464
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.48513539
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.47590830
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46991703
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.46161252
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45142762
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43957664
41	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43858954
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.41486345
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.37441865
44	AR_25329375_ChIP-Seq_VCAP_Human	1.33179282
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31855841
46	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.30991403
47	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.29058370
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28941958
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28941958
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.28837525
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27595212
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27313729
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26965074
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26207824
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26207824
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22857005
57	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22503406
58	AR_20517297_ChIP-Seq_VCAP_Human	1.21772978
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21111409
60	STAT3_23295773_ChIP-Seq_U87_Human	1.20392053
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18348014
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17720706
63	TCF4_23295773_ChIP-Seq_U87_Human	1.16258408
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15991019
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15780084
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15770526
67	NCOR_22424771_ChIP-Seq_293T_Human	1.15284959
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14245436
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.14200973
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13994231
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12641015
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11990813
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11254700
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.11135121
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08896107
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08540979
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07996327
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07635152
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07131726
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07131726
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06053434
82	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05930148
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.05152832
84	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04850092
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03899586
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03259043
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03191920
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02709056
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02139530
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01802164
91	GATA3_26560356_Chip-Seq_TH2_Human	1.01055295
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00921223
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00918654
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00898167
95	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00700542
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00298793
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99945498
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98394698
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98018925
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97303467

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.29228847
2	MP0006072_abnormal_retinal_apoptosis	2.53600388
3	MP0006292_abnormal_olfactory_placode	2.52444100
4	MP0005084_abnormal_gallbladder_morpholo	2.47466791
5	MP0002837_dystrophic_cardiac_calcinosis	2.45149714
6	MP0005646_abnormal_pituitary_gland	2.40040458
7	MP0002102_abnormal_ear_morphology	2.39957200
8	MP0003787_abnormal_imprinting	2.35242667
9	MP0000372_irregular_coat_pigmentation	2.33002445
10	MP0005551_abnormal_eye_electrophysiolog	2.20723220
11	MP0003195_calcinosis	2.12167092
12	MP0005645_abnormal_hypothalamus_physiol	2.11864766
13	MP0002653_abnormal_ependyma_morphology	2.03458914
14	MP0001986_abnormal_taste_sensitivity	2.00565964
15	MP0008058_abnormal_DNA_repair	1.99793243
16	MP0001968_abnormal_touch/_nociception	1.98036697
17	MP0002638_abnormal_pupillary_reflex	1.92340764
18	MP0008872_abnormal_physiological_respon	1.74173256
19	MP0005253_abnormal_eye_physiology	1.70559184
20	MP0001984_abnormal_olfaction	1.70182269
21	MP0009046_muscle_twitch	1.68607645
22	MP0005075_abnormal_melanosome_morpholog	1.68386339
23	MP0003880_abnormal_central_pattern	1.66539567
24	MP0008995_early_reproductive_senescence	1.63015021
25	MP0009745_abnormal_behavioral_response	1.61847044
26	MP0004147_increased_porphyrin_level	1.59755495
27	MP0002272_abnormal_nervous_system	1.57736928
28	MP0001529_abnormal_vocalization	1.56344624
29	MP0002876_abnormal_thyroid_physiology	1.55433025
30	MP0002736_abnormal_nociception_after	1.50673954
31	MP0004142_abnormal_muscle_tone	1.50469809
32	MP0000569_abnormal_digit_pigmentation	1.46221720
33	MP0006276_abnormal_autonomic_nervous	1.41056813
34	MP0010386_abnormal_urinary_bladder	1.39717364
35	MP0001905_abnormal_dopamine_level	1.37873706
36	MP0008875_abnormal_xenobiotic_pharmacok	1.34561014
37	MP0002928_abnormal_bile_duct	1.30215668
38	MP0001501_abnormal_sleep_pattern	1.30004272
39	MP0005174_abnormal_tail_pigmentation	1.28661436
40	MP0002163_abnormal_gland_morphology	1.28081192
41	MP0004043_abnormal_pH_regulation	1.26871890
42	MP0002160_abnormal_reproductive_system	1.24753997
43	MP0003121_genomic_imprinting	1.23570266
44	MP0004133_heterotaxia	1.23279424
45	MP0001486_abnormal_startle_reflex	1.22048744
46	MP0000631_abnormal_neuroendocrine_gland	1.21378629
47	MP0001764_abnormal_homeostasis	1.20023100
48	MP0005410_abnormal_fertilization	1.18656188
49	MP0002938_white_spotting	1.18371329
50	MP0002095_abnormal_skin_pigmentation	1.18370629
51	MP0005379_endocrine/exocrine_gland_phen	1.18335969
52	MP0003718_maternal_effect	1.18146767
53	MP0008961_abnormal_basal_metabolism	1.16506375
54	MP0003806_abnormal_nucleotide_metabolis	1.16202124
55	MP0001485_abnormal_pinna_reflex	1.16078317
56	MP0008789_abnormal_olfactory_epithelium	1.13965674
57	MP0004885_abnormal_endolymph	1.13759128
58	MP0005389_reproductive_system_phenotype	1.13571654
59	MP0003011_delayed_dark_adaptation	1.13389162
60	MP0006036_abnormal_mitochondrial_physio	1.13220916
61	MP0002572_abnormal_emotion/affect_behav	1.12591455
62	MP0002735_abnormal_chemical_nociception	1.11917270
63	MP0003252_abnormal_bile_duct	1.06578030
64	MP0003786_premature_aging	1.06287649
65	MP0003186_abnormal_redox_activity	1.06188046
66	MP0005671_abnormal_response_to	1.04629136
67	MP0004742_abnormal_vestibular_system	1.04338653
68	MP0004145_abnormal_muscle_electrophysio	1.02834706
69	MP0002064_seizures	1.00830916
70	MP0002822_catalepsy	1.00730802
71	MP0001970_abnormal_pain_threshold	1.00481347
72	MP0002693_abnormal_pancreas_physiology	0.99865619
73	MP0002751_abnormal_autonomic_nervous	0.98932360
74	MP0001929_abnormal_gametogenesis	0.98436962
75	MP0002733_abnormal_thermal_nociception	0.97651742
76	MP0002557_abnormal_social/conspecific_i	0.96680131
77	MP0004924_abnormal_behavior	0.95350468
78	MP0005386_behavior/neurological_phenoty	0.95350468
79	MP0003136_yellow_coat_color	0.93192122
80	MP0003283_abnormal_digestive_organ	0.92909536
81	MP0009697_abnormal_copulation	0.92676276
82	MP0003698_abnormal_male_reproductive	0.90932606
83	MP0005220_abnormal_exocrine_pancreas	0.89393624
84	MP0002067_abnormal_sensory_capabilities	0.88148023
85	MP0002234_abnormal_pharynx_morphology	0.87434522
86	MP0000427_abnormal_hair_cycle	0.84822441
87	MP0005195_abnormal_posterior_eye	0.83861107
88	MP0002277_abnormal_respiratory_mucosa	0.83832014
89	MP0003635_abnormal_synaptic_transmissio	0.83827831
90	MP0001835_abnormal_antigen_presentation	0.83662776
91	MP0003646_muscle_fatigue	0.82880945
92	MP0002229_neurodegeneration	0.81713288
93	MP0002210_abnormal_sex_determination	0.81652593
94	MP0001919_abnormal_reproductive_system	0.80398846
95	MP0005332_abnormal_amino_acid	0.80060299
96	MP0000653_abnormal_sex_gland	0.78927089
97	MP0000230_abnormal_systemic_arterial	0.75103186
98	MP0006035_abnormal_mitochondrial_morpho	0.73887275
99	MP0002138_abnormal_hepatobiliary_system	0.73736157
100	MP0005394_taste/olfaction_phenotype	0.73592842

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.87776744
2	Abnormality of midbrain morphology (HP:0002418)	3.81968449
3	Molar tooth sign on MRI (HP:0002419)	3.81968449
4	Pancreatic fibrosis (HP:0100732)	3.70152810
5	Mitochondrial inheritance (HP:0001427)	3.60441935
6	Acute necrotizing encephalopathy (HP:0006965)	3.60129561
7	True hermaphroditism (HP:0010459)	3.59171891
8	Hepatocellular necrosis (HP:0001404)	3.31044357
9	Nephronophthisis (HP:0000090)	3.30486045
10	Medial flaring of the eyebrow (HP:0010747)	3.27443818
11	Increased CSF lactate (HP:0002490)	3.27040191
12	Progressive macrocephaly (HP:0004481)	3.20025113
13	Congenital stationary night blindness (HP:0007642)	3.18365677
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18154550
15	Acute encephalopathy (HP:0006846)	3.11621661
16	Hepatic necrosis (HP:0002605)	3.11338434
17	Hypothermia (HP:0002045)	3.06130543
18	Lipid accumulation in hepatocytes (HP:0006561)	2.85384676
19	Abnormality of the renal medulla (HP:0100957)	2.85005249
20	Increased hepatocellular lipid droplets (HP:0006565)	2.81173843
21	Abnormality of the renal cortex (HP:0011035)	2.80563483
22	Renal cortical cysts (HP:0000803)	2.72519253
23	3-Methylglutaconic aciduria (HP:0003535)	2.67067796
24	Renal Fanconi syndrome (HP:0001994)	2.63182528
25	Abolished electroretinogram (ERG) (HP:0000550)	2.61230619
26	Type II lissencephaly (HP:0007260)	2.60941351
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.58610823
28	Methylmalonic acidemia (HP:0002912)	2.58460364
29	Gait imbalance (HP:0002141)	2.55364604
30	Congenital primary aphakia (HP:0007707)	2.54858151
31	Cystic liver disease (HP:0006706)	2.44868378
32	Attenuation of retinal blood vessels (HP:0007843)	2.43250703
33	Nephrogenic diabetes insipidus (HP:0009806)	2.39878210
34	Hyperventilation (HP:0002883)	2.39365363
35	Methylmalonic aciduria (HP:0012120)	2.32454587
36	Abnormality of renal resorption (HP:0011038)	2.29800629
37	Optic disc pallor (HP:0000543)	2.29198852
38	Cerebral edema (HP:0002181)	2.27699015
39	Gaze-evoked nystagmus (HP:0000640)	2.22037976
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.21162176
41	Male pseudohermaphroditism (HP:0000037)	2.08449586
42	Chronic hepatic failure (HP:0100626)	2.07892324
43	Lactic acidosis (HP:0003128)	2.06347446
44	Genital tract atresia (HP:0001827)	2.05786105
45	Sclerocornea (HP:0000647)	2.05582747
46	Increased serum lactate (HP:0002151)	2.05277726
47	Febrile seizures (HP:0002373)	2.04514305
48	Decreased central vision (HP:0007663)	2.03831106
49	Increased intramyocellular lipid droplets (HP:0012240)	2.02807733
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01053270
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99289395
52	Polydipsia (HP:0001959)	1.96058779
53	Abnormal drinking behavior (HP:0030082)	1.96058779
54	Exertional dyspnea (HP:0002875)	1.95799229
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95610880
56	Thyroiditis (HP:0100646)	1.95374106
57	Abnormality of the labia minora (HP:0012880)	1.94963005
58	Polyuria (HP:0000103)	1.93559788
59	Inability to walk (HP:0002540)	1.92933442
60	Vaginal atresia (HP:0000148)	1.92818331
61	Congenital hepatic fibrosis (HP:0002612)	1.92765011
62	Glycosuria (HP:0003076)	1.92069600
63	Abnormality of urine glucose concentration (HP:0011016)	1.92069600
64	Postaxial foot polydactyly (HP:0001830)	1.90589905
65	Broad-based gait (HP:0002136)	1.89141401
66	Respiratory failure (HP:0002878)	1.88929437
67	Type I transferrin isoform profile (HP:0003642)	1.88744054
68	Abnormal protein glycosylation (HP:0012346)	1.88073042
69	Abnormal glycosylation (HP:0012345)	1.88073042
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88073042
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.88073042
72	Ketosis (HP:0001946)	1.87488863
73	Pendular nystagmus (HP:0012043)	1.85923480
74	Progressive cerebellar ataxia (HP:0002073)	1.85360117
75	Colon cancer (HP:0003003)	1.83038203
76	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81028180
77	Cerebellar dysplasia (HP:0007033)	1.79149068
78	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78939932
79	Abnormality of alanine metabolism (HP:0010916)	1.78939932
80	Hyperalaninemia (HP:0003348)	1.78939932
81	Severe combined immunodeficiency (HP:0004430)	1.78558870
82	Short tibia (HP:0005736)	1.77884969
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75748951
84	Absent/shortened dynein arms (HP:0200106)	1.75748951
85	Focal motor seizures (HP:0011153)	1.75533973
86	Anencephaly (HP:0002323)	1.74238697
87	Increased muscle lipid content (HP:0009058)	1.74057408
88	Ketoacidosis (HP:0001993)	1.73638187
89	Postaxial hand polydactyly (HP:0001162)	1.72762658
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.71945594
91	Lissencephaly (HP:0001339)	1.71933805
92	Hyperglycinemia (HP:0002154)	1.71459507
93	Lethargy (HP:0001254)	1.71086804
94	Large for gestational age (HP:0001520)	1.70562897
95	Constricted visual fields (HP:0001133)	1.69646178
96	Progressive inability to walk (HP:0002505)	1.69320615
97	Bile duct proliferation (HP:0001408)	1.68836570
98	Abnormal biliary tract physiology (HP:0012439)	1.68836570
99	Retinal dysplasia (HP:0007973)	1.65994463
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.65534706

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.59085201
2	MAP4K2	3.74049177
3	TAOK3	3.71079948
4	NUAK1	2.59044749
5	WNK3	2.45972100
6	ADRBK2	2.37051793
7	BMPR1B	2.25645967
8	ZAK	2.25570052
9	PINK1	2.23721152
10	BCKDK	2.15762793
11	GRK1	2.08692777
12	MAPK13	2.02716415
13	TXK	1.96685654
14	TLK1	1.95462950
15	VRK2	1.92469442
16	VRK1	1.89240137
17	INSRR	1.69460570
18	MAP3K4	1.43444271
19	CASK	1.37412728
20	WNK4	1.35585533
21	ACVR1B	1.22399371
22	CCNB1	1.22289234
23	MST4	1.19711891
24	TEC	1.09198756
25	NTRK2	1.07977988
26	KIT	1.07224931
27	MAP2K7	1.07054430
28	DYRK2	1.06004960
29	PAK3	1.01510681
30	OXSR1	0.99131649
31	CAMKK2	0.98830996
32	PLK4	0.97149814
33	TNIK	0.97119145
34	TNK2	0.96463703
35	STK39	0.94672184
36	TRIM28	0.94660736
37	CSNK1G2	0.91055089
38	CSNK1G3	0.87144310
39	IKBKB	0.86099657
40	PRKCE	0.84937291
41	PLK2	0.80893826
42	CSNK1G1	0.80345571
43	CDK8	0.80002312
44	MAP4K1	0.79473469
45	ERBB3	0.78702759
46	STK16	0.77383258
47	PRKCQ	0.76314505
48	FLT3	0.74805914
49	MUSK	0.74071380
50	BMPR2	0.73367071
51	PKN1	0.71446654
52	EIF2AK3	0.69812551
53	PHKG2	0.68835842
54	PHKG1	0.68835842
55	ADRBK1	0.68343082
56	PIK3CG	0.68222960
57	PNCK	0.66774176
58	BCR	0.65690059
59	PRKCG	0.65354164
60	SYK	0.64873213
61	CSNK1A1L	0.62728126
62	RPS6KA5	0.61238440
63	MAPK15	0.60296818
64	KDR	0.59216889
65	ITK	0.58378546
66	MAPKAPK5	0.58274259
67	MKNK2	0.58236840
68	BRSK2	0.58230912
69	MARK3	0.57454207
70	PLK3	0.56919814
71	IKBKE	0.56257358
72	DAPK2	0.55860533
73	NTRK3	0.55702779
74	MAPKAPK3	0.54865312
75	PTK2B	0.51680062
76	OBSCN	0.51678104
77	PASK	0.50953447
78	CAMK2A	0.50604756
79	PRKACA	0.50271314
80	MARK1	0.47089153
81	GRK5	0.46725290
82	MAP2K6	0.46582170
83	NEK2	0.46559245
84	FES	0.46415815
85	STK38L	0.46138774
86	CAMK1	0.45653349
87	ATR	0.44350300
88	LYN	0.43812134
89	CDC7	0.42503658
90	CSNK1A1	0.41349032
91	CDK3	0.41313359
92	BTK	0.39449008
93	ATM	0.38351850
94	LCK	0.37684350
95	FGFR2	0.37649039
96	PRKG1	0.37058911
97	PRKCA	0.36051177
98	TESK2	0.35909244
99	STK3	0.35272031
100	AKT3	0.34067333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58084254
2	Parkinsons disease_Homo sapiens_hsa05012	2.89826166
3	Protein export_Homo sapiens_hsa03060	2.78491358
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63678756
5	Homologous recombination_Homo sapiens_hsa03440	2.46515777
6	Phototransduction_Homo sapiens_hsa04744	2.35730151
7	RNA polymerase_Homo sapiens_hsa03020	2.16694669
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.14463117
9	Huntingtons disease_Homo sapiens_hsa05016	1.79133856
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78083042
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76509304
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75169310
13	Butanoate metabolism_Homo sapiens_hsa00650	1.74171124
14	Proteasome_Homo sapiens_hsa03050	1.72882124
15	Alzheimers disease_Homo sapiens_hsa05010	1.72764256
16	Olfactory transduction_Homo sapiens_hsa04740	1.68236931
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66839613
18	RNA degradation_Homo sapiens_hsa03018	1.64378039
19	Basal transcription factors_Homo sapiens_hsa03022	1.63801764
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.61209550
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.56340672
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.56137450
23	Ribosome_Homo sapiens_hsa03010	1.53592398
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51396037
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49260525
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48714582
27	Regulation of autophagy_Homo sapiens_hsa04140	1.44364266
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44091312
29	Propanoate metabolism_Homo sapiens_hsa00640	1.42517044
30	Asthma_Homo sapiens_hsa05310	1.39779965
31	Nicotine addiction_Homo sapiens_hsa05033	1.36395823
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35216478
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.35152035
34	Mismatch repair_Homo sapiens_hsa03430	1.32814666
35	Peroxisome_Homo sapiens_hsa04146	1.31729338
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29807995
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28132654
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26576188
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.24183668
40	Taste transduction_Homo sapiens_hsa04742	1.21395658
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.14043805
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.13693817
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.09377229
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.06929163
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06864194
46	Nucleotide excision repair_Homo sapiens_hsa03420	1.06389216
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05947999
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05038676
49	Caffeine metabolism_Homo sapiens_hsa00232	1.04609324
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02447980
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00948918
52	Purine metabolism_Homo sapiens_hsa00230	1.00312665
53	Graft-versus-host disease_Homo sapiens_hsa05332	1.00038467
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94727599
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.91686881
56	Allograft rejection_Homo sapiens_hsa05330	0.91670001
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91160164
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91143142
59	Base excision repair_Homo sapiens_hsa03410	0.89913014
60	Insulin secretion_Homo sapiens_hsa04911	0.83533526
61	Sulfur metabolism_Homo sapiens_hsa00920	0.82503807
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82289701
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81112247
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81024374
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80741081
66	Fatty acid elongation_Homo sapiens_hsa00062	0.79402220
67	One carbon pool by folate_Homo sapiens_hsa00670	0.77323320
68	Retinol metabolism_Homo sapiens_hsa00830	0.76518399
69	Morphine addiction_Homo sapiens_hsa05032	0.76236924
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74952778
71	Metabolic pathways_Homo sapiens_hsa01100	0.70082976
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69904806
73	GABAergic synapse_Homo sapiens_hsa04727	0.67765467
74	Circadian entrainment_Homo sapiens_hsa04713	0.67414347
75	Salivary secretion_Homo sapiens_hsa04970	0.65209496
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65149485
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63388333
78	DNA replication_Homo sapiens_hsa03030	0.60298219
79	ABC transporters_Homo sapiens_hsa02010	0.59551141
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57010330
81	Serotonergic synapse_Homo sapiens_hsa04726	0.56796228
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55232994
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54297134
84	Glutathione metabolism_Homo sapiens_hsa00480	0.51766278
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48367401
86	Folate biosynthesis_Homo sapiens_hsa00790	0.47962205
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.45869111
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.45416644
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45020320
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.44738126
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44187375
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42770045
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42087449
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40159685
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39728457
96	Amphetamine addiction_Homo sapiens_hsa05031	0.38896400
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35956438
98	Spliceosome_Homo sapiens_hsa03040	0.35314766
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32946706
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32351292

FRG1HP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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