ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.41481733
2	piRNA metabolic process (GO:0034587)	4.44270072
3	respiratory chain complex IV assembly (GO:0008535)	4.33641078
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.02808717
5	cytochrome complex assembly (GO:0017004)	3.90687188
6	protein complex biogenesis (GO:0070271)	3.87093744
7	platelet dense granule organization (GO:0060155)	3.66093491
8	DNA methylation involved in gamete generation (GO:0043046)	3.61933091
9	preassembly of GPI anchor in ER membrane (GO:0016254)	3.56890476
10	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52101046
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47647664
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47647664
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38114827
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34578134
15	NADH dehydrogenase complex assembly (GO:0010257)	3.34578134
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34578134
17	cellular ketone body metabolic process (GO:0046950)	3.33818569
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.28013074
19	inositol phosphate catabolic process (GO:0071545)	3.25275707
20	mannosylation (GO:0097502)	3.15453365
21	protein deneddylation (GO:0000338)	3.14543262
22	cytidine deamination (GO:0009972)	3.13648466
23	cytidine metabolic process (GO:0046087)	3.13648466
24	cytidine catabolic process (GO:0006216)	3.13648466
25	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.11660279
26	inositol phosphate dephosphorylation (GO:0046855)	3.11660279
27	ketone body metabolic process (GO:1902224)	3.09738422
28	electron transport chain (GO:0022900)	3.05705049
29	ubiquinone biosynthetic process (GO:0006744)	3.05451571
30	respiratory electron transport chain (GO:0022904)	3.04889493
31	ATP synthesis coupled proton transport (GO:0015986)	3.03154753
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.03154753
33	rRNA modification (GO:0000154)	3.01930152
34	cullin deneddylation (GO:0010388)	3.00981264
35	adenosine metabolic process (GO:0046085)	3.00285307
36	metallo-sulfur cluster assembly (GO:0031163)	2.99807780
37	iron-sulfur cluster assembly (GO:0016226)	2.99807780
38	positive regulation of mitochondrial fission (GO:0090141)	2.99351622
39	branched-chain amino acid catabolic process (GO:0009083)	2.98386445
40	positive regulation of defense response to virus by host (GO:0002230)	2.96523500
41	positive regulation of prostaglandin secretion (GO:0032308)	2.96305769
42	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.94709855
43	C-terminal protein lipidation (GO:0006501)	2.92474207
44	signal peptide processing (GO:0006465)	2.91207788
45	male meiosis I (GO:0007141)	2.90208845
46	GPI anchor biosynthetic process (GO:0006506)	2.88806724
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.87448251
48	negative regulation of membrane potential (GO:0045837)	2.86384789
49	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86297468
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.85681490
51	regulation of glucokinase activity (GO:0033131)	2.84532996
52	regulation of hexokinase activity (GO:1903299)	2.84532996
53	GPI anchor metabolic process (GO:0006505)	2.84009711
54	ubiquinone metabolic process (GO:0006743)	2.82237924
55	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.81964415
56	proteasome assembly (GO:0043248)	2.79220490
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77682136
58	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.75400642
59	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.74094690
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.70438667
61	L-methionine salvage (GO:0071267)	2.65770736
62	L-methionine biosynthetic process (GO:0071265)	2.65770736
63	amino acid salvage (GO:0043102)	2.65770736
64	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.65376160
65	aldehyde catabolic process (GO:0046185)	2.64798141
66	dopamine transport (GO:0015872)	2.62824174
67	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.61217629
68	maturation of 5.8S rRNA (GO:0000460)	2.59708086
69	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.59253839
70	ATP hydrolysis coupled proton transport (GO:0015991)	2.59253839
71	peptidyl-histidine modification (GO:0018202)	2.58891363
72	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.58439984
73	L-phenylalanine catabolic process (GO:0006559)	2.58439984
74	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.58154315
75	regulation of mitochondrial translation (GO:0070129)	2.57943637
76	regulation of memory T cell differentiation (GO:0043380)	2.57718442
77	branched-chain amino acid metabolic process (GO:0009081)	2.56448543
78	polyol catabolic process (GO:0046174)	2.55507647
79	purine deoxyribonucleotide metabolic process (GO:0009151)	2.55244652
80	negative regulation of telomere maintenance (GO:0032205)	2.55144899
81	axoneme assembly (GO:0035082)	2.55048794
82	pseudouridine synthesis (GO:0001522)	2.54334083
83	regulation of cilium movement (GO:0003352)	2.54165951
84	meiosis I (GO:0007127)	2.53704028
85	DNA double-strand break processing (GO:0000729)	2.52335739
86	termination of RNA polymerase III transcription (GO:0006386)	2.50863088
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50863088
88	C-terminal protein amino acid modification (GO:0018410)	2.50747692
89	regulation of meiosis I (GO:0060631)	2.50071697
90	protein K6-linked ubiquitination (GO:0085020)	2.49840615
91	fucose catabolic process (GO:0019317)	2.48637071
92	L-fucose metabolic process (GO:0042354)	2.48637071
93	L-fucose catabolic process (GO:0042355)	2.48637071
94	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.46893450
95	ribonucleoprotein complex disassembly (GO:0032988)	2.45764479
96	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.45535518
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.45079813
98	isotype switching (GO:0045190)	2.45079813
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.45079813
100	proton transport (GO:0015992)	2.44743652

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.94209072
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.77637866
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67399371
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.35335452
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98468061
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90652205
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.87910615
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84132674
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.77938182
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.56730893
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.50433826
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.48567691
13	VDR_22108803_ChIP-Seq_LS180_Human	2.42489825
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30347184
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.27317501
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.20970180
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05595446
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.02775851
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95042801
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.88051225
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87021706
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75768950
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.74756179
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69039457
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.66693172
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.63415004
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.62906928
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.60878538
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.60866095
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60296794
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53328723
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53063845
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52972738
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52752217
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51139248
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47788954
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47784992
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47721827
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.46213564
40	AR_20517297_ChIP-Seq_VCAP_Human	1.44586793
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40564982
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40564982
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38854724
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38183523
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.38042632
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38042632
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35996119
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.34792803
49	GATA3_26560356_Chip-Seq_TH2_Human	1.33558710
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.33153665
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.30917278
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30430404
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28133303
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28133303
55	FUS_26573619_Chip-Seq_HEK293_Human	1.25681737
56	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23360914
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22175201
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22090747
59	EWS_26573619_Chip-Seq_HEK293_Human	1.20769980
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20006037
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18852298
62	P300_19829295_ChIP-Seq_ESCs_Human	1.18228304
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16850288
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15983687
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.15937601
66	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15656584
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15131487
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15015141
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14266128
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13259595
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12878482
72	NCOR_22424771_ChIP-Seq_293T_Human	1.12289083
73	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11084292
74	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.09122789
75	TAF15_26573619_Chip-Seq_HEK293_Human	1.08405767
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07069615
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06380516
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06032809
79	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05478958
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02820707
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02452344
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01554796
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.01117154
84	ERG_20517297_ChIP-Seq_VCAP_Human	1.01026306
85	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01013381
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00567188
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98967253
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97976017
89	MYB_26560356_Chip-Seq_TH2_Human	0.97952159
90	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96072529
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95858898
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.95327213
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93786496
94	GATA3_27048872_Chip-Seq_THYMUS_Human	0.91110138
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.90561135
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89585525
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89473389
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87353818
99	KDM5A_27292631_Chip-Seq_BREAST_Human	0.87219968
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87153821

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.16382764
2	MP0003195_calcinosis	3.74454721
3	MP0004147_increased_porphyrin_level	3.06044741
4	MP0008877_abnormal_DNA_methylation	3.03018451
5	MP0005075_abnormal_melanosome_morpholog	2.87385820
6	MP0000372_irregular_coat_pigmentation	2.44753060
7	MP0002653_abnormal_ependyma_morphology	2.37595565
8	MP0006072_abnormal_retinal_apoptosis	2.26361243
9	MP0008875_abnormal_xenobiotic_pharmacok	2.23770842
10	MP0003806_abnormal_nucleotide_metabolis	2.15170403
11	MP0005671_abnormal_response_to	2.05364154
12	MP0008058_abnormal_DNA_repair	1.85837784
13	MP0001764_abnormal_homeostasis	1.82538402
14	MP0005084_abnormal_gallbladder_morpholo	1.79580156
15	MP0008872_abnormal_physiological_respon	1.79104271
16	MP0006036_abnormal_mitochondrial_physio	1.76351971
17	MP0009697_abnormal_copulation	1.75981477
18	MP0002102_abnormal_ear_morphology	1.68680223
19	MP0005645_abnormal_hypothalamus_physiol	1.61551413
20	MP0005410_abnormal_fertilization	1.60918992
21	MP0002693_abnormal_pancreas_physiology	1.60872221
22	MP0005551_abnormal_eye_electrophysiolog	1.60852507
23	MP0001984_abnormal_olfaction	1.59553366
24	MP0001986_abnormal_taste_sensitivity	1.56461322
25	MP0005379_endocrine/exocrine_gland_phen	1.54585496
26	MP0006292_abnormal_olfactory_placode	1.47165683
27	MP0009046_muscle_twitch	1.46889353
28	MP0002876_abnormal_thyroid_physiology	1.46450052
29	MP0003786_premature_aging	1.44939346
30	MP0002160_abnormal_reproductive_system	1.44930587
31	MP0002166_altered_tumor_susceptibility	1.44716693
32	MP0005253_abnormal_eye_physiology	1.40877832
33	MP0001501_abnormal_sleep_pattern	1.39739281
34	MP0005646_abnormal_pituitary_gland	1.38291446
35	MP0008995_early_reproductive_senescence	1.37397403
36	MP0001905_abnormal_dopamine_level	1.36883900
37	MP0005085_abnormal_gallbladder_physiolo	1.36796340
38	MP0002638_abnormal_pupillary_reflex	1.35951376
39	MP0005332_abnormal_amino_acid	1.35043731
40	MP0005389_reproductive_system_phenotype	1.34566558
41	MP0003186_abnormal_redox_activity	1.33587800
42	MP0002163_abnormal_gland_morphology	1.33452529
43	MP0003252_abnormal_bile_duct	1.32374157
44	MP0002138_abnormal_hepatobiliary_system	1.25524828
45	MP0001529_abnormal_vocalization	1.23520757
46	MP0003718_maternal_effect	1.22422026
47	MP0001835_abnormal_antigen_presentation	1.19370453
48	MP0005365_abnormal_bile_salt	1.18975209
49	MP0005636_abnormal_mineral_homeostasis	1.17116593
50	MP0006276_abnormal_autonomic_nervous	1.14928773
51	MP0003045_fibrosis	1.14107910
52	MP0002006_tumorigenesis	1.13480228
53	MP0002909_abnormal_adrenal_gland	1.12727011
54	MP0003011_delayed_dark_adaptation	1.10181989
55	MP0004043_abnormal_pH_regulation	1.09583867
56	MP0006035_abnormal_mitochondrial_morpho	1.07648813
57	MP0009785_altered_susceptibility_to	1.06142539
58	MP0005220_abnormal_exocrine_pancreas	1.05728769
59	MP0002095_abnormal_skin_pigmentation	1.05424194
60	MP0004142_abnormal_muscle_tone	1.04384741
61	MP0001968_abnormal_touch/_nociception	1.04087183
62	MP0003763_abnormal_thymus_physiology	1.03723395
63	MP0005000_abnormal_immune_tolerance	1.02670157
64	MP0010386_abnormal_urinary_bladder	1.02115069
65	MP0003787_abnormal_imprinting	0.99868895
66	MP0001800_abnormal_humoral_immune	0.99635627
67	MP0002272_abnormal_nervous_system	0.99465129
68	MP0002736_abnormal_nociception_after	0.98883984
69	MP0002148_abnormal_hypersensitivity_rea	0.97232153
70	MP0005171_absent_coat_pigmentation	0.93480824
71	MP0002723_abnormal_immune_serum	0.92497523
72	MP0002928_abnormal_bile_duct	0.92281510
73	MP0010329_abnormal_lipoprotein_level	0.92260991
74	MP0002938_white_spotting	0.92021969
75	MP0009745_abnormal_behavioral_response	0.90545164
76	MP0001661_extended_life_span	0.89990398
77	MP0004145_abnormal_muscle_electrophysio	0.89677559
78	MP0001944_abnormal_pancreas_morphology	0.88238413
79	MP0001929_abnormal_gametogenesis	0.88007844
80	MP0001919_abnormal_reproductive_system	0.86592534
81	MP0002139_abnormal_hepatobiliary_system	0.83071752
82	MP0009780_abnormal_chondrocyte_physiolo	0.82145792
83	MP0005174_abnormal_tail_pigmentation	0.82033776
84	MP0004215_abnormal_myocardial_fiber	0.81149714
85	MP0003283_abnormal_digestive_organ	0.80836626
86	MP0000685_abnormal_immune_system	0.79824579
87	MP0005647_abnormal_sex_gland	0.79704347
88	MP0005408_hypopigmentation	0.79085344
89	MP0006054_spinal_hemorrhage	0.79018012
90	MP0003866_abnormal_defecation	0.77386367
91	MP0002229_neurodegeneration	0.75921524
92	MP0004381_abnormal_hair_follicle	0.75803239
93	MP0002078_abnormal_glucose_homeostasis	0.75276503
94	MP0001765_abnormal_ion_homeostasis	0.75106393
95	MP0000689_abnormal_spleen_morphology	0.73860156
96	MP0003698_abnormal_male_reproductive	0.73583086
97	MP0005535_abnormal_body_temperature	0.72101313
98	MP0001756_abnormal_urination	0.71769306
99	MP0009333_abnormal_splenocyte_physiolog	0.71549908
100	MP0000653_abnormal_sex_gland	0.71316977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.10183221
2	Hepatic necrosis (HP:0002605)	4.09314265
3	Mitochondrial inheritance (HP:0001427)	4.08952950
4	Acute necrotizing encephalopathy (HP:0006965)	3.92714839
5	Increased CSF lactate (HP:0002490)	3.74777518
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.70603225
7	Progressive macrocephaly (HP:0004481)	3.61463236
8	Acute encephalopathy (HP:0006846)	3.48469453
9	Pancreatic cysts (HP:0001737)	3.33185120
10	Increased hepatocellular lipid droplets (HP:0006565)	3.14137260
11	Ketoacidosis (HP:0001993)	3.10150474
12	Aplastic anemia (HP:0001915)	3.05534644
13	Hypothermia (HP:0002045)	3.05296730
14	Lipid accumulation in hepatocytes (HP:0006561)	3.00331759
15	Renal cortical cysts (HP:0000803)	2.99948656
16	Pancreatic fibrosis (HP:0100732)	2.99311988
17	Renal Fanconi syndrome (HP:0001994)	2.92190701
18	Increased intramyocellular lipid droplets (HP:0012240)	2.81529067
19	Increased serum lactate (HP:0002151)	2.81489147
20	Abnormality of the renal cortex (HP:0011035)	2.79398808
21	True hermaphroditism (HP:0010459)	2.75380471
22	Cerebral edema (HP:0002181)	2.72450140
23	Lactic acidosis (HP:0003128)	2.69718505
24	Severe combined immunodeficiency (HP:0004430)	2.68673253
25	Ketosis (HP:0001946)	2.62001604
26	Medial flaring of the eyebrow (HP:0010747)	2.60575795
27	Hypoglycemic coma (HP:0001325)	2.60222183
28	Nephronophthisis (HP:0000090)	2.55608167
29	Congenital stationary night blindness (HP:0007642)	2.54987947
30	Thyroiditis (HP:0100646)	2.53632540
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.52767970
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.52767970
33	Abnormality of midbrain morphology (HP:0002418)	2.52651712
34	Molar tooth sign on MRI (HP:0002419)	2.52651712
35	Respiratory failure (HP:0002878)	2.42380905
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.41271635
37	Increased muscle lipid content (HP:0009058)	2.40762184
38	Optic disc pallor (HP:0000543)	2.40190123
39	3-Methylglutaconic aciduria (HP:0003535)	2.40109739
40	Large for gestational age (HP:0001520)	2.32217075
41	Hypoproteinemia (HP:0003075)	2.30871903
42	Cystic liver disease (HP:0006706)	2.27356284
43	Methylmalonic acidemia (HP:0002912)	2.26882518
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25151301
45	IgG deficiency (HP:0004315)	2.22181483
46	Aplasia/hypoplasia of the uterus (HP:0008684)	2.22119940
47	Abnormality of urine glucose concentration (HP:0011016)	2.21092760
48	Glycosuria (HP:0003076)	2.21092760
49	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.20488690
50	Abnormal protein N-linked glycosylation (HP:0012347)	2.20488690
51	Abnormal protein glycosylation (HP:0012346)	2.20488690
52	Abnormal glycosylation (HP:0012345)	2.20488690
53	Methylmalonic aciduria (HP:0012120)	2.19417828
54	Hypomagnesemia (HP:0002917)	2.19030199
55	Abnormality of the renal medulla (HP:0100957)	2.18762950
56	Generalized aminoaciduria (HP:0002909)	2.17874527
57	Type I transferrin isoform profile (HP:0003642)	2.16640204
58	Progressive inability to walk (HP:0002505)	2.14203741
59	Dicarboxylic aciduria (HP:0003215)	2.11672322
60	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.11672322
61	Stomatitis (HP:0010280)	2.11334972
62	Hypoglycemic seizures (HP:0002173)	2.10308667
63	CNS demyelination (HP:0007305)	2.10071215
64	Abolished electroretinogram (ERG) (HP:0000550)	2.09271051
65	Attenuation of retinal blood vessels (HP:0007843)	2.08168246
66	Lethargy (HP:0001254)	2.07754467
67	Hyperglycinemia (HP:0002154)	2.01795843
68	Nephrogenic diabetes insipidus (HP:0009806)	2.01655951
69	Exertional dyspnea (HP:0002875)	2.01306882
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99497069
71	Abnormality of the pancreatic islet cells (HP:0006476)	1.98338153
72	Abnormality of endocrine pancreas physiology (HP:0012093)	1.98338153
73	Hyperinsulinemic hypoglycemia (HP:0000825)	1.97498581
74	Congenital primary aphakia (HP:0007707)	1.97436185
75	Chronic hepatic failure (HP:0100626)	1.94387068
76	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.94142187
77	Combined immunodeficiency (HP:0005387)	1.94059008
78	Abnormality of alanine metabolism (HP:0010916)	1.93905609
79	Hyperalaninemia (HP:0003348)	1.93905609
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93905609
81	Emotional lability (HP:0000712)	1.91840627
82	Tongue fasciculations (HP:0001308)	1.91320250
83	Gait imbalance (HP:0002141)	1.90536020
84	Exercise intolerance (HP:0003546)	1.90165582
85	Pancreatic islet-cell hyperplasia (HP:0004510)	1.89972522
86	Abnormal rod and cone electroretinograms (HP:0008323)	1.89562790
87	Hyperglycemia (HP:0003074)	1.88185157
88	Type II lissencephaly (HP:0007260)	1.85352317
89	Elevated erythrocyte sedimentation rate (HP:0003565)	1.81842567
90	Hypoplasia of the fovea (HP:0007750)	1.81151311
91	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.81151311
92	Progressive microcephaly (HP:0000253)	1.80880719
93	Short tibia (HP:0005736)	1.80336717
94	Abnormality of renal resorption (HP:0011038)	1.80276815
95	Abnormal drinking behavior (HP:0030082)	1.75150015
96	Polydipsia (HP:0001959)	1.75150015
97	Adrenal hypoplasia (HP:0000835)	1.73631485
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72680892
99	Pancytopenia (HP:0001876)	1.72577240
100	Inability to walk (HP:0002540)	1.70000047

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.24420627
2	MAP4K2	3.46977498
3	BCKDK	3.00259074
4	TXK	2.76770204
5	TESK2	2.62392887
6	NUAK1	2.35467843
7	PASK	2.18180106
8	TAOK3	2.15863021
9	ZAK	1.95249886
10	WNK3	1.91325642
11	ADRBK2	1.89342993
12	MST4	1.84153383
13	KDR	1.72386883
14	INSRR	1.61945969
15	VRK2	1.60859966
16	CSNK1G3	1.60507475
17	PINK1	1.59411407
18	TRIM28	1.58143737
19	ERBB3	1.58089259
20	STK38L	1.57649259
21	MAP3K12	1.56423551
22	BMPR2	1.43705489
23	WNK4	1.42012501
24	GRK1	1.37742556
25	CSNK1G1	1.33757733
26	PHKG1	1.33427231
27	PHKG2	1.33427231
28	CSNK1G2	1.32732929
29	BCR	1.31996480
30	EIF2AK3	1.31180491
31	CSNK1A1L	1.28545706
32	MAPKAPK3	1.26501988
33	MAPK13	1.19344524
34	KIT	1.14690210
35	TEC	1.10928768
36	VRK1	1.10205935
37	BMPR1B	1.09766697
38	LIMK1	1.06766804
39	IKBKB	1.02803868
40	PIM2	1.02049336
41	TLK1	1.01648701
42	BRSK2	1.00509622
43	ACVR1B	0.99758875
44	SRPK1	0.99573334
45	CAMKK2	0.98820184
46	ITK	0.92568750
47	TESK1	0.89387171
48	MUSK	0.86276785
49	PLK2	0.83380205
50	PRKCQ	0.82431760
51	STK16	0.80874337
52	SYK	0.80144589
53	STK39	0.78962459
54	DAPK1	0.77230564
55	DAPK2	0.76560965
56	MAP2K7	0.75825317
57	OXSR1	0.70460901
58	IKBKE	0.70014623
59	EIF2AK1	0.69064450
60	EPHA3	0.66231073
61	DYRK2	0.65491187
62	RPS6KA5	0.64376026
63	SIK3	0.64302781
64	NME1	0.63745885
65	LCK	0.63307282
66	PRKCE	0.63008550
67	LATS1	0.62391389
68	GRK7	0.61714380
69	MAP2K6	0.61650996
70	PLK4	0.60215554
71	PLK3	0.60215238
72	RIPK4	0.57003864
73	PIK3CG	0.54799762
74	MAP3K4	0.54709032
75	PTK2B	0.53400210
76	MAPKAPK5	0.53027498
77	ADRBK1	0.51978715
78	FLT3	0.48978997
79	PRKCI	0.48495559
80	PAK3	0.47661993
81	BUB1	0.47188842
82	LYN	0.46662662
83	NEK1	0.43788120
84	MAP2K2	0.42858722
85	STK3	0.42412442
86	MAP3K5	0.39398677
87	FES	0.39315672
88	NLK	0.37857111
89	CSNK1A1	0.37626489
90	IGF1R	0.36820420
91	CCNB1	0.34453202
92	FER	0.34157528
93	PRKACA	0.34137469
94	ABL1	0.34001794
95	GRK5	0.32963682
96	CSF1R	0.32639549
97	FGFR2	0.32390598
98	PRKCA	0.31135980
99	CAMK2A	0.30806659
100	TNK2	0.30594418

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.91636729
2	Proteasome_Homo sapiens_hsa03050	3.18856116
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17350066
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.83848160
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.63945991
6	Parkinsons disease_Homo sapiens_hsa05012	2.44267358
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15062167
8	Phototransduction_Homo sapiens_hsa04744	2.14145183
9	RNA polymerase_Homo sapiens_hsa03020	2.13521768
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.02722914
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00767654
12	Butanoate metabolism_Homo sapiens_hsa00650	1.82849941
13	Fatty acid elongation_Homo sapiens_hsa00062	1.80455159
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.77376997
15	Homologous recombination_Homo sapiens_hsa03440	1.73738011
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.67070266
17	Propanoate metabolism_Homo sapiens_hsa00640	1.65283135
18	Caffeine metabolism_Homo sapiens_hsa00232	1.61470516
19	Sulfur metabolism_Homo sapiens_hsa00920	1.51569864
20	Peroxisome_Homo sapiens_hsa04146	1.50641979
21	Alzheimers disease_Homo sapiens_hsa05010	1.48012789
22	Huntingtons disease_Homo sapiens_hsa05016	1.42169765
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.40627413
24	Basal transcription factors_Homo sapiens_hsa03022	1.40121903
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.36973762
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.35365921
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31668653
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.31072401
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29746023
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28073009
31	Regulation of autophagy_Homo sapiens_hsa04140	1.26053055
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.21906939
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19140168
34	Asthma_Homo sapiens_hsa05310	1.16653038
35	One carbon pool by folate_Homo sapiens_hsa00670	1.15969659
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.13460946
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12744512
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11821632
39	RNA degradation_Homo sapiens_hsa03018	1.11354323
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.11048933
41	Allograft rejection_Homo sapiens_hsa05330	1.10638907
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.09243046
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07845946
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07713116
45	Mismatch repair_Homo sapiens_hsa03430	1.05443320
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04501995
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.03752965
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00986282
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00686732
50	Purine metabolism_Homo sapiens_hsa00230	0.98345246
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97536504
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96773983
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95655161
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94470010
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93288484
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.91283878
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87491864
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.87020809
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.85929841
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.84347788
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.82002125
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81279823
63	Metabolic pathways_Homo sapiens_hsa01100	0.80457497
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80400282
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.80248095
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79072281
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76878209
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73588854
69	Retinol metabolism_Homo sapiens_hsa00830	0.68944315
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.67201697
71	Antigen processing and presentation_Homo sapiens_hsa04612	0.67135687
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66520442
73	Folate biosynthesis_Homo sapiens_hsa00790	0.66216880
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66001372
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64269662
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63006042
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62254953
78	Insulin secretion_Homo sapiens_hsa04911	0.61833779
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61578832
80	Sulfur relay system_Homo sapiens_hsa04122	0.60915361
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60630670
82	Taste transduction_Homo sapiens_hsa04742	0.59243615
83	Olfactory transduction_Homo sapiens_hsa04740	0.57685969
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54881280
85	Fatty acid degradation_Homo sapiens_hsa00071	0.54874786
86	Glutathione metabolism_Homo sapiens_hsa00480	0.54771789
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52693577
88	Ribosome_Homo sapiens_hsa03010	0.51323171
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.47355484
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.46553432
91	Nicotine addiction_Homo sapiens_hsa05033	0.45931977
92	Base excision repair_Homo sapiens_hsa03410	0.44333648
93	ABC transporters_Homo sapiens_hsa02010	0.44100360
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40486827
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38121516
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37448519
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.36092917
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36074354
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.32069210
100	RNA transport_Homo sapiens_hsa03013	0.31384482

FRG1JP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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