FRG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)5.96137675
2positive regulation of meiosis (GO:0045836)5.16843803
3positive regulation of meiotic cell cycle (GO:0051446)4.81237322
4piRNA metabolic process (GO:0034587)4.70256463
5behavioral response to nicotine (GO:0035095)4.61639470
6male meiosis I (GO:0007141)4.41845724
7synaptonemal complex organization (GO:0070193)4.28978802
8indole-containing compound catabolic process (GO:0042436)4.27142690
9indolalkylamine catabolic process (GO:0046218)4.27142690
10tryptophan catabolic process (GO:0006569)4.27142690
11kynurenine metabolic process (GO:0070189)4.13683481
12male meiosis (GO:0007140)4.06697990
13multicellular organism reproduction (GO:0032504)3.99622808
14L-fucose catabolic process (GO:0042355)3.95324785
15fucose catabolic process (GO:0019317)3.95324785
16L-fucose metabolic process (GO:0042354)3.95324785
17synaptonemal complex assembly (GO:0007130)3.90688940
18indolalkylamine metabolic process (GO:0006586)3.89406901
19chromosome organization involved in meiosis (GO:0070192)3.71685437
20epithelial cilium movement (GO:0003351)3.71215410
21tryptophan metabolic process (GO:0006568)3.66686896
22rRNA catabolic process (GO:0016075)3.66180309
23oocyte development (GO:0048599)3.64556080
24DNA methylation involved in gamete generation (GO:0043046)3.63281969
25dopamine transport (GO:0015872)3.60025495
26meiosis I (GO:0007127)3.58074476
27axoneme assembly (GO:0035082)3.57946148
28regulation of acrosome reaction (GO:0060046)3.43870194
29synapsis (GO:0007129)3.42166555
30glycerophospholipid catabolic process (GO:0046475)3.38747928
31respiratory chain complex IV assembly (GO:0008535)3.38591169
32regulation of meiosis I (GO:0060631)3.36838597
33regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.36794625
34indole-containing compound metabolic process (GO:0042430)3.31101618
35reciprocal meiotic recombination (GO:0007131)3.18009838
36reciprocal DNA recombination (GO:0035825)3.18009838
37mitochondrial RNA metabolic process (GO:0000959)3.17883725
38cilium movement (GO:0003341)3.15050793
39DNA deamination (GO:0045006)3.12976045
40mitochondrial respiratory chain complex assembly (GO:0033108)3.11442403
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11000906
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.11000906
43NADH dehydrogenase complex assembly (GO:0010257)3.11000906
44protein K6-linked ubiquitination (GO:0085020)3.10510950
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08013160
46centriole replication (GO:0007099)3.05249324
47replication fork processing (GO:0031297)3.04932154
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02372616
49protein complex biogenesis (GO:0070271)3.01836551
50double-strand break repair via homologous recombination (GO:0000724)2.96786301
51recombinational repair (GO:0000725)2.95733091
52serotonin metabolic process (GO:0042428)2.92406131
53water-soluble vitamin biosynthetic process (GO:0042364)2.89913445
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.88536800
55regulation of meiosis (GO:0040020)2.88042293
56response to pheromone (GO:0019236)2.87169299
57meiotic chromosome segregation (GO:0045132)2.86479492
58positive regulation of prostaglandin secretion (GO:0032308)2.85994681
59amine catabolic process (GO:0009310)2.85268191
60cellular biogenic amine catabolic process (GO:0042402)2.85268191
61primary amino compound metabolic process (GO:1901160)2.83816935
62inositol phosphate catabolic process (GO:0071545)2.82343794
63inositol phosphate dephosphorylation (GO:0046855)2.80781526
64phosphorylated carbohydrate dephosphorylation (GO:0046838)2.80781526
65cellular ketone body metabolic process (GO:0046950)2.77157004
66meiotic cell cycle (GO:0051321)2.76952730
67cAMP catabolic process (GO:0006198)2.76288705
68regulation of female receptivity (GO:0045924)2.75472273
69benzene-containing compound metabolic process (GO:0042537)2.73887781
70meiotic cell cycle process (GO:1903046)2.71938517
71cytochrome complex assembly (GO:0017004)2.70901019
72adaptation of signaling pathway (GO:0023058)2.70741733
73aromatic amino acid family catabolic process (GO:0009074)2.69894851
74regulation of neurotransmitter uptake (GO:0051580)2.68530449
75regulation of DNA endoreduplication (GO:0032875)2.65472775
76retinal cone cell development (GO:0046549)2.63476311
77meiotic nuclear division (GO:0007126)2.61848336
78tachykinin receptor signaling pathway (GO:0007217)2.61351504
79acrosome reaction (GO:0007340)2.61107758
80NAD biosynthetic process (GO:0009435)2.58654272
81polyol catabolic process (GO:0046174)2.58377373
82single fertilization (GO:0007338)2.54698563
83reproduction (GO:0000003)2.52997639
84positive regulation of fatty acid transport (GO:2000193)2.52823870
85cyclic nucleotide catabolic process (GO:0009214)2.52690523
86pseudouridine synthesis (GO:0001522)2.51529898
87protein K63-linked deubiquitination (GO:0070536)2.46223753
88spermatid development (GO:0007286)2.45412317
89ketone body metabolic process (GO:1902224)2.45095605
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44292109
91neuronal action potential (GO:0019228)2.43975162
92regulation of hexokinase activity (GO:1903299)2.43964239
93regulation of glucokinase activity (GO:0033131)2.43964239
94protein polyglutamylation (GO:0018095)2.42915008
95oxidative demethylation (GO:0070989)2.42108700
96hindbrain development (GO:0030902)2.41356330
97regulation of centriole replication (GO:0046599)2.40233973
98regulation of meiotic cell cycle (GO:0051445)2.39656693
99regulation of defense response to virus by host (GO:0050691)2.37924378
100negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37501965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.97309729
2EZH2_22144423_ChIP-Seq_EOC_Human3.64803729
3GBX2_23144817_ChIP-Seq_PC3_Human3.28101679
4ZNF274_21170338_ChIP-Seq_K562_Hela3.17499213
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06880874
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88312599
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52486452
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49012068
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44974334
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.39539758
11IGF1R_20145208_ChIP-Seq_DFB_Human2.34383350
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26029125
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23929427
14TAF15_26573619_Chip-Seq_HEK293_Human2.18041389
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15738119
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.02222001
17P300_19829295_ChIP-Seq_ESCs_Human2.00229534
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.95448697
19IRF1_19129219_ChIP-ChIP_H3396_Human1.94801277
20EWS_26573619_Chip-Seq_HEK293_Human1.93220430
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92300187
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86852244
23FUS_26573619_Chip-Seq_HEK293_Human1.84016161
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72200882
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71531915
26* TCF4_23295773_ChIP-Seq_U87_Human1.68263295
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67344355
28STAT3_23295773_ChIP-Seq_U87_Human1.64790555
29SMAD4_21799915_ChIP-Seq_A2780_Human1.64375582
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63814360
31AR_25329375_ChIP-Seq_VCAP_Human1.62893444
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59605639
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59573205
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.59441640
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58970652
36ER_23166858_ChIP-Seq_MCF-7_Human1.58800421
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58203524
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57395118
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56671967
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56277484
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.55161953
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54585683
43CBP_20019798_ChIP-Seq_JUKART_Human1.54585683
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49531840
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49023388
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47986414
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46416781
48TP53_22573176_ChIP-Seq_HFKS_Human1.46045644
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45245758
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.43592934
51MYC_18940864_ChIP-ChIP_HL60_Human1.41532574
52RNF2_27304074_Chip-Seq_NSC_Mouse1.40736297
53BCAT_22108803_ChIP-Seq_LS180_Human1.40268574
54TCF4_22108803_ChIP-Seq_LS180_Human1.40150139
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37271669
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36792977
57NCOR_22424771_ChIP-Seq_293T_Human1.35904241
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.34652745
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.33475629
60REST_21632747_ChIP-Seq_MESCs_Mouse1.33062165
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32320210
62RUNX2_22187159_ChIP-Seq_PCA_Human1.31704510
63* PRDM14_20953172_ChIP-Seq_ESCs_Human1.31646544
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28327093
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27866065
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26746213
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26354566
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24357402
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.19984370
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.17784394
71* NANOG_19829295_ChIP-Seq_ESCs_Human1.14196793
72* SOX2_19829295_ChIP-Seq_ESCs_Human1.14196793
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.12640199
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10564132
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10063608
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.09009350
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08873347
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.06627351
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06312387
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06181816
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.05870199
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05870199
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.05699755
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04591869
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03969781
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03742830
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02974936
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01740013
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01594868
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01389530
91SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99842718
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99510360
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99309998
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99239252
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99239252
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98601157
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.97783583
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97278134
99AR_20517297_ChIP-Seq_VCAP_Human0.96824010
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96646786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.75781660
2MP0008877_abnormal_DNA_methylation3.43169168
3MP0003283_abnormal_digestive_organ3.15355782
4MP0003136_yellow_coat_color2.89752847
5MP0002102_abnormal_ear_morphology2.66822774
6MP0000427_abnormal_hair_cycle2.40251264
7MP0002160_abnormal_reproductive_system2.26164278
8MP0003195_calcinosis2.17374739
9MP0008872_abnormal_physiological_respon2.10655177
10MP0003718_maternal_effect2.04907391
11MP0005551_abnormal_eye_electrophysiolog2.02449735
12MP0006276_abnormal_autonomic_nervous2.02267318
13MP0002837_dystrophic_cardiac_calcinosis1.98488540
14MP0000372_irregular_coat_pigmentation1.94080444
15MP0002163_abnormal_gland_morphology1.92201077
16MP0002876_abnormal_thyroid_physiology1.89126756
17MP0009046_muscle_twitch1.86612406
18MP0008058_abnormal_DNA_repair1.84518703
19MP0004142_abnormal_muscle_tone1.81079732
20MP0000569_abnormal_digit_pigmentation1.80098671
21MP0005645_abnormal_hypothalamus_physiol1.79382958
22MP0003950_abnormal_plasma_membrane1.74543880
23MP0000631_abnormal_neuroendocrine_gland1.73635926
24MP0001929_abnormal_gametogenesis1.72897296
25MP0004043_abnormal_pH_regulation1.70830275
26MP0002210_abnormal_sex_determination1.70658495
27MP0005646_abnormal_pituitary_gland1.69918658
28MP0003787_abnormal_imprinting1.69800843
29MP0001968_abnormal_touch/_nociception1.69200387
30MP0009745_abnormal_behavioral_response1.68558405
31MP0005389_reproductive_system_phenotype1.64201325
32MP0005410_abnormal_fertilization1.60981885
33MP0001986_abnormal_taste_sensitivity1.58823301
34MP0005379_endocrine/exocrine_gland_phen1.56848818
35MP0002272_abnormal_nervous_system1.55250046
36MP0002138_abnormal_hepatobiliary_system1.53673252
37MP0006072_abnormal_retinal_apoptosis1.53223474
38MP0002653_abnormal_ependyma_morphology1.52135305
39MP0003646_muscle_fatigue1.51101618
40MP0002751_abnormal_autonomic_nervous1.46354359
41MP0003119_abnormal_digestive_system1.40692277
42MP0002736_abnormal_nociception_after1.39439429
43MP0004147_increased_porphyrin_level1.35796535
44MP0004742_abnormal_vestibular_system1.33375525
45MP0003698_abnormal_male_reproductive1.29367680
46MP0004885_abnormal_endolymph1.29275102
47MP0005253_abnormal_eye_physiology1.26992227
48MP0005084_abnormal_gallbladder_morpholo1.24197930
49MP0000653_abnormal_sex_gland1.22935977
50MP0003693_abnormal_embryo_hatching1.21933834
51MP0003890_abnormal_embryonic-extraembry1.20611524
52MP0002234_abnormal_pharynx_morphology1.17926234
53MP0002638_abnormal_pupillary_reflex1.17809150
54MP0000049_abnormal_middle_ear1.17647470
55MP0001485_abnormal_pinna_reflex1.17542468
56MP0004133_heterotaxia1.16187988
57MP0001502_abnormal_circadian_rhythm1.15771117
58MP0003121_genomic_imprinting1.14262585
59MP0002938_white_spotting1.13668124
60MP0008875_abnormal_xenobiotic_pharmacok1.12795060
61MP0001486_abnormal_startle_reflex1.12436205
62MP0002693_abnormal_pancreas_physiology1.11245080
63MP0001145_abnormal_male_reproductive1.09703802
64MP0002184_abnormal_innervation1.08953403
65MP0003880_abnormal_central_pattern1.08573993
66MP0002557_abnormal_social/conspecific_i1.08000532
67MP0000230_abnormal_systemic_arterial1.04029300
68MP0001293_anophthalmia1.02166223
69MP0005174_abnormal_tail_pigmentation1.02100383
70MP0000678_abnormal_parathyroid_gland1.01341700
71MP0008995_early_reproductive_senescence1.01335725
72MP0005220_abnormal_exocrine_pancreas1.00850214
73MP0001664_abnormal_digestion1.00813074
74MP0002067_abnormal_sensory_capabilities0.98777187
75MP0000015_abnormal_ear_pigmentation0.98084190
76MP0001905_abnormal_dopamine_level0.97693819
77MP0001944_abnormal_pancreas_morphology0.96663487
78MP0000778_abnormal_nervous_system0.96504019
79MP0000647_abnormal_sebaceous_gland0.96276924
80MP0001119_abnormal_female_reproductive0.95211379
81MP0002095_abnormal_skin_pigmentation0.95001470
82MP0002572_abnormal_emotion/affect_behav0.94718552
83MP0003635_abnormal_synaptic_transmissio0.94288407
84MP0000470_abnormal_stomach_morphology0.93649192
85MP0003938_abnormal_ear_development0.93455551
86MP0001919_abnormal_reproductive_system0.90559716
87MP0002277_abnormal_respiratory_mucosa0.89903218
88MP0002064_seizures0.87741502
89MP0002229_neurodegeneration0.87673612
90MP0005195_abnormal_posterior_eye0.86813665
91MP0001501_abnormal_sleep_pattern0.84785246
92MP0005075_abnormal_melanosome_morpholog0.84330559
93MP0003699_abnormal_female_reproductive0.81501966
94MP0002063_abnormal_learning/memory/cond0.80681128
95MP0004134_abnormal_chest_morphology0.79615497
96MP0001529_abnormal_vocalization0.77463625
97MP0001440_abnormal_grooming_behavior0.76612392
98MP0010094_abnormal_chromosome_stability0.74645620
99MP0005360_urolithiasis0.74127812
100MP0002161_abnormal_fertility/fecundity0.73699593

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.17643635
2Abnormality of midbrain morphology (HP:0002418)3.84709312
3Molar tooth sign on MRI (HP:0002419)3.84709312
4Pancreatic cysts (HP:0001737)3.67298253
5Abnormality of the labia minora (HP:0012880)3.58398543
6True hermaphroditism (HP:0010459)3.28026937
7Oligodactyly (hands) (HP:0001180)3.20156504
8Abnormality of alanine metabolism (HP:0010916)3.00574469
9Hyperalaninemia (HP:0003348)3.00574469
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00574469
11Nephronophthisis (HP:0000090)2.96621217
12Type II lissencephaly (HP:0007260)2.91622348
13Abnormality of the renal cortex (HP:0011035)2.88419867
14Aplasia/Hypoplasia of the tibia (HP:0005772)2.79097747
15Aplasia/Hypoplasia of the tongue (HP:0010295)2.76063857
16Chronic hepatic failure (HP:0100626)2.69686977
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65923554
18Abnormal rod and cone electroretinograms (HP:0008323)2.61538377
19Medial flaring of the eyebrow (HP:0010747)2.59880109
20Disproportionate short-trunk short stature (HP:0003521)2.57503078
21Abnormality of the renal medulla (HP:0100957)2.54579739
22Abnormality of the pons (HP:0007361)2.51828911
23Attenuation of retinal blood vessels (HP:0007843)2.51010735
24Pendular nystagmus (HP:0012043)2.50765517
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.49106441
26Hypoplasia of the fovea (HP:0007750)2.49106441
27Abolished electroretinogram (ERG) (HP:0000550)2.46082543
28Gaze-evoked nystagmus (HP:0000640)2.41964468
29Congenital sensorineural hearing impairment (HP:0008527)2.40649460
30Congenital stationary night blindness (HP:0007642)2.38270579
31Adrenal hypoplasia (HP:0000835)2.36865270
32Short tibia (HP:0005736)2.34544842
33Tubular atrophy (HP:0000092)2.34311001
34Abnormality of the fovea (HP:0000493)2.33955016
35Polydipsia (HP:0001959)2.32704236
36Abnormal drinking behavior (HP:0030082)2.32704236
37Sclerocornea (HP:0000647)2.31249343
38Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30935462
39Hypoplasia of the pons (HP:0012110)2.30257008
40Limb dystonia (HP:0002451)2.29459129
41Median cleft lip (HP:0000161)2.23656846
42Postaxial foot polydactyly (HP:0001830)2.22895202
43Congenital, generalized hypertrichosis (HP:0004540)2.19562471
44Bony spicule pigmentary retinopathy (HP:0007737)2.19510271
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.18322108
46Aplasia/Hypoplasia of the patella (HP:0006498)2.17187379
47Metaphyseal dysplasia (HP:0100255)2.16994957
48Cystic liver disease (HP:0006706)2.16958357
49Patellar aplasia (HP:0006443)2.16221561
50Acute necrotizing encephalopathy (HP:0006965)2.15233046
51Increased corneal curvature (HP:0100692)2.13202116
52Keratoconus (HP:0000563)2.13202116
53Optic nerve hypoplasia (HP:0000609)2.12734420
54Ketoacidosis (HP:0001993)2.12429191
55Mitochondrial inheritance (HP:0001427)2.11683846
56Increased CSF lactate (HP:0002490)2.10202082
57Oligodactyly (HP:0012165)2.07668213
58Lipid accumulation in hepatocytes (HP:0006561)2.07497006
59Renal cortical cysts (HP:0000803)2.05307630
60Abnormality of lateral ventricle (HP:0030047)2.03704480
613-Methylglutaconic aciduria (HP:0003535)2.00074359
62Bilateral microphthalmos (HP:0007633)1.99940157
63Increased hepatocellular lipid droplets (HP:0006565)1.99932533
64Decreased circulating renin level (HP:0003351)1.99057444
65Retinal dysplasia (HP:0007973)1.97614337
66Gait imbalance (HP:0002141)1.96672627
67Premature ovarian failure (HP:0008209)1.95281776
68Clubbing of toes (HP:0100760)1.94790164
69Atonic seizures (HP:0010819)1.94773557
70Dynein arm defect of respiratory motile cilia (HP:0012255)1.94390944
71Absent/shortened dynein arms (HP:0200106)1.94390944
72Fair hair (HP:0002286)1.94292231
73Preaxial hand polydactyly (HP:0001177)1.93023390
74Congenital primary aphakia (HP:0007707)1.91808628
75Ectopic kidney (HP:0000086)1.91401368
76Genital tract atresia (HP:0001827)1.90805697
77Progressive macrocephaly (HP:0004481)1.89819328
78Ketosis (HP:0001946)1.89580003
79Cerebellar dysplasia (HP:0007033)1.89507682
80Meckel diverticulum (HP:0002245)1.87781957
81Conical tooth (HP:0000698)1.87730422
82Decreased central vision (HP:0007663)1.87534842
83Progressive inability to walk (HP:0002505)1.85550365
84Concave nail (HP:0001598)1.85487680
85Abnormality of the ileum (HP:0001549)1.84861098
86Pachygyria (HP:0001302)1.83505910
87Congenital hepatic fibrosis (HP:0002612)1.83234830
88Nephrogenic diabetes insipidus (HP:0009806)1.82840212
89Large for gestational age (HP:0001520)1.81832070
90Abnormality of chromosome stability (HP:0003220)1.81813624
91Postaxial hand polydactyly (HP:0001162)1.80339342
92Tachypnea (HP:0002789)1.78801038
93Inability to walk (HP:0002540)1.78629262
94Glycosuria (HP:0003076)1.77270862
95Abnormality of urine glucose concentration (HP:0011016)1.77270862
96Anencephaly (HP:0002323)1.76750000
97Methylmalonic acidemia (HP:0002912)1.76711704
98Renal Fanconi syndrome (HP:0001994)1.76145055
99Increased serum lactate (HP:0002151)1.74073768
100Febrile seizures (HP:0002373)1.74026053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.09378671
2TLK14.14487063
3ZAK3.11011977
4ADRBK22.87399064
5NUAK12.79715664
6BMPR1B2.78851322
7MAP4K22.58660562
8STK392.30436850
9STK162.29870630
10WNK42.26023899
11GRK12.15949515
12TAOK32.04028948
13ACVR1B1.99803327
14PINK11.97095910
15TNIK1.94647893
16PLK41.89239257
17MAPK131.85022835
18INSRR1.82568567
19VRK11.75051381
20DAPK21.59326844
21NTRK31.58367766
22VRK21.52436142
23OXSR11.48482648
24MAP3K41.45001595
25TRIM281.37406496
26WNK31.31550247
27MAP2K71.26259780
28EPHA41.21806562
29PLK21.21798624
30TEC1.13681418
31CSNK1G11.11305444
32NLK1.08486682
33PKN11.02632017
34STK30.96675647
35AURKA0.89555889
36STK38L0.88795356
37BUB10.87912956
38PDK20.85672603
39CSNK1G20.84990543
40WNK10.84704903
41DYRK20.84604594
42MST40.83600129
43PLK10.81413003
44PLK30.80027089
45PHKG10.78496644
46PHKG20.78496644
47TGFBR10.76830639
48PAK30.76537472
49RPS6KA50.75826768
50ADRBK10.74850598
51CSNK1G30.72409972
52CDK30.71524386
53IRAK10.71388849
54STK240.69925093
55MKNK20.69544503
56PRKCE0.68507288
57PIK3CA0.68262330
58GRK50.65610147
59NTRK20.65063693
60PNCK0.63783778
61CHEK20.62697546
62PTK2B0.61589369
63CAMKK20.60766103
64BRSK20.60382551
65PRKCG0.60201121
66MAPKAPK50.56487984
67MARK30.56209374
68SGK20.55579953
69PRKCI0.55381503
70BCKDK0.54237592
71TXK0.53412625
72EIF2AK30.52443535
73BCR0.50986437
74TTK0.50863020
75CAMK2A0.50809611
76PRKCQ0.50359839
77PRKAA10.49714191
78ATR0.48452033
79CDK190.47687173
80CAMK10.47441065
81PRKACA0.46151335
82MAP2K60.45135724
83NEK20.44589759
84ATM0.43969838
85CASK0.43518286
86STK110.42085700
87CSNK1D0.41374954
88CDC70.38245559
89PRKG10.35911776
90CSNK1E0.35847641
91CSNK1A10.35833835
92MARK10.35477663
93SGK2230.33717445
94SGK4940.33717445
95FGFR20.32450598
96ILK0.32410816
97MAP2K40.32330939
98CDK80.32273347
99AURKB0.30818098
100DYRK30.27671072

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.95231401
2Butanoate metabolism_Homo sapiens_hsa006502.50594125
3Phototransduction_Homo sapiens_hsa047442.47736789
4Homologous recombination_Homo sapiens_hsa034402.47484469
5Selenocompound metabolism_Homo sapiens_hsa004502.45815922
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.41479803
7Linoleic acid metabolism_Homo sapiens_hsa005912.33059211
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24229800
9Protein export_Homo sapiens_hsa030602.19868978
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16337997
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12612724
12Fanconi anemia pathway_Homo sapiens_hsa034602.05972723
13Basal transcription factors_Homo sapiens_hsa030222.03870665
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00641032
15Nitrogen metabolism_Homo sapiens_hsa009101.97438579
16RNA polymerase_Homo sapiens_hsa030201.96621934
17Tryptophan metabolism_Homo sapiens_hsa003801.95023463
18Olfactory transduction_Homo sapiens_hsa047401.80998773
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74001252
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60927057
21Oxidative phosphorylation_Homo sapiens_hsa001901.59879780
22Nicotine addiction_Homo sapiens_hsa050331.58477920
23Insulin secretion_Homo sapiens_hsa049111.56185607
24Dorso-ventral axis formation_Homo sapiens_hsa043201.54301400
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52817782
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43012438
27Morphine addiction_Homo sapiens_hsa050321.33826548
28Parkinsons disease_Homo sapiens_hsa050121.31056259
29RNA degradation_Homo sapiens_hsa030181.30715455
30Ether lipid metabolism_Homo sapiens_hsa005651.27908620
31Ovarian steroidogenesis_Homo sapiens_hsa049131.21756168
32ABC transporters_Homo sapiens_hsa020101.20332753
33Sulfur metabolism_Homo sapiens_hsa009201.20039219
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.19567813
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14053357
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12162689
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11446007
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.05387743
39Caffeine metabolism_Homo sapiens_hsa002321.04598808
40Retinol metabolism_Homo sapiens_hsa008301.04434047
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.03232810
42Serotonergic synapse_Homo sapiens_hsa047261.03114987
43Fatty acid elongation_Homo sapiens_hsa000621.03058689
44Collecting duct acid secretion_Homo sapiens_hsa049661.02483541
45GABAergic synapse_Homo sapiens_hsa047271.00828149
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99152081
47Regulation of autophagy_Homo sapiens_hsa041400.98732702
48Pyrimidine metabolism_Homo sapiens_hsa002400.98080719
49Taste transduction_Homo sapiens_hsa047420.97695661
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97293473
51Huntingtons disease_Homo sapiens_hsa050160.92678093
52Non-homologous end-joining_Homo sapiens_hsa034500.92320150
53Purine metabolism_Homo sapiens_hsa002300.91815258
54RNA transport_Homo sapiens_hsa030130.90230628
55Circadian entrainment_Homo sapiens_hsa047130.89240260
56Cocaine addiction_Homo sapiens_hsa050300.88938925
57Chemical carcinogenesis_Homo sapiens_hsa052040.87541723
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86675036
59Glutamatergic synapse_Homo sapiens_hsa047240.85036980
60Propanoate metabolism_Homo sapiens_hsa006400.81346319
61Ribosome_Homo sapiens_hsa030100.80851276
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80829193
63Dopaminergic synapse_Homo sapiens_hsa047280.79325074
64Vitamin B6 metabolism_Homo sapiens_hsa007500.78954960
65One carbon pool by folate_Homo sapiens_hsa006700.78680693
66Salivary secretion_Homo sapiens_hsa049700.77432913
67Arachidonic acid metabolism_Homo sapiens_hsa005900.76149700
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.74466236
69Bile secretion_Homo sapiens_hsa049760.72860933
70Circadian rhythm_Homo sapiens_hsa047100.71919998
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71660020
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68616480
73Cardiac muscle contraction_Homo sapiens_hsa042600.64460923
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63292257
75Amphetamine addiction_Homo sapiens_hsa050310.62971106
76Calcium signaling pathway_Homo sapiens_hsa040200.61861203
77Oocyte meiosis_Homo sapiens_hsa041140.57579211
78Mismatch repair_Homo sapiens_hsa034300.55390532
79Peroxisome_Homo sapiens_hsa041460.54730460
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54722278
81Alzheimers disease_Homo sapiens_hsa050100.52404471
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51456306
83Metabolic pathways_Homo sapiens_hsa011000.49622389
84beta-Alanine metabolism_Homo sapiens_hsa004100.48422935
85Synaptic vesicle cycle_Homo sapiens_hsa047210.46961738
86Mineral absorption_Homo sapiens_hsa049780.45342093
87Fatty acid metabolism_Homo sapiens_hsa012120.43045845
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41530215
89Hedgehog signaling pathway_Homo sapiens_hsa043400.41328693
90Asthma_Homo sapiens_hsa053100.41262046
91Cholinergic synapse_Homo sapiens_hsa047250.41207449
92cAMP signaling pathway_Homo sapiens_hsa040240.40895368
93Fat digestion and absorption_Homo sapiens_hsa049750.39602280
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.38870445
95Lysine degradation_Homo sapiens_hsa003100.37062739
96Renin secretion_Homo sapiens_hsa049240.34873933
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34142367
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32531005
99Fatty acid biosynthesis_Homo sapiens_hsa000610.31072672
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30681318

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »