ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K9 demethylation (GO:0033169)	5.96137675
2	positive regulation of meiosis (GO:0045836)	5.16843803
3	positive regulation of meiotic cell cycle (GO:0051446)	4.81237322
4	piRNA metabolic process (GO:0034587)	4.70256463
5	behavioral response to nicotine (GO:0035095)	4.61639470
6	male meiosis I (GO:0007141)	4.41845724
7	synaptonemal complex organization (GO:0070193)	4.28978802
8	indole-containing compound catabolic process (GO:0042436)	4.27142690
9	indolalkylamine catabolic process (GO:0046218)	4.27142690
10	tryptophan catabolic process (GO:0006569)	4.27142690
11	kynurenine metabolic process (GO:0070189)	4.13683481
12	male meiosis (GO:0007140)	4.06697990
13	multicellular organism reproduction (GO:0032504)	3.99622808
14	L-fucose catabolic process (GO:0042355)	3.95324785
15	fucose catabolic process (GO:0019317)	3.95324785
16	L-fucose metabolic process (GO:0042354)	3.95324785
17	synaptonemal complex assembly (GO:0007130)	3.90688940
18	indolalkylamine metabolic process (GO:0006586)	3.89406901
19	chromosome organization involved in meiosis (GO:0070192)	3.71685437
20	epithelial cilium movement (GO:0003351)	3.71215410
21	tryptophan metabolic process (GO:0006568)	3.66686896
22	rRNA catabolic process (GO:0016075)	3.66180309
23	oocyte development (GO:0048599)	3.64556080
24	DNA methylation involved in gamete generation (GO:0043046)	3.63281969
25	dopamine transport (GO:0015872)	3.60025495
26	meiosis I (GO:0007127)	3.58074476
27	axoneme assembly (GO:0035082)	3.57946148
28	regulation of acrosome reaction (GO:0060046)	3.43870194
29	synapsis (GO:0007129)	3.42166555
30	glycerophospholipid catabolic process (GO:0046475)	3.38747928
31	respiratory chain complex IV assembly (GO:0008535)	3.38591169
32	regulation of meiosis I (GO:0060631)	3.36838597
33	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.36794625
34	indole-containing compound metabolic process (GO:0042430)	3.31101618
35	reciprocal meiotic recombination (GO:0007131)	3.18009838
36	reciprocal DNA recombination (GO:0035825)	3.18009838
37	mitochondrial RNA metabolic process (GO:0000959)	3.17883725
38	cilium movement (GO:0003341)	3.15050793
39	DNA deamination (GO:0045006)	3.12976045
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11442403
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11000906
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11000906
43	NADH dehydrogenase complex assembly (GO:0010257)	3.11000906
44	protein K6-linked ubiquitination (GO:0085020)	3.10510950
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.08013160
46	centriole replication (GO:0007099)	3.05249324
47	replication fork processing (GO:0031297)	3.04932154
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02372616
49	protein complex biogenesis (GO:0070271)	3.01836551
50	double-strand break repair via homologous recombination (GO:0000724)	2.96786301
51	recombinational repair (GO:0000725)	2.95733091
52	serotonin metabolic process (GO:0042428)	2.92406131
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.89913445
54	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88536800
55	regulation of meiosis (GO:0040020)	2.88042293
56	response to pheromone (GO:0019236)	2.87169299
57	meiotic chromosome segregation (GO:0045132)	2.86479492
58	positive regulation of prostaglandin secretion (GO:0032308)	2.85994681
59	amine catabolic process (GO:0009310)	2.85268191
60	cellular biogenic amine catabolic process (GO:0042402)	2.85268191
61	primary amino compound metabolic process (GO:1901160)	2.83816935
62	inositol phosphate catabolic process (GO:0071545)	2.82343794
63	inositol phosphate dephosphorylation (GO:0046855)	2.80781526
64	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.80781526
65	cellular ketone body metabolic process (GO:0046950)	2.77157004
66	meiotic cell cycle (GO:0051321)	2.76952730
67	cAMP catabolic process (GO:0006198)	2.76288705
68	regulation of female receptivity (GO:0045924)	2.75472273
69	benzene-containing compound metabolic process (GO:0042537)	2.73887781
70	meiotic cell cycle process (GO:1903046)	2.71938517
71	cytochrome complex assembly (GO:0017004)	2.70901019
72	adaptation of signaling pathway (GO:0023058)	2.70741733
73	aromatic amino acid family catabolic process (GO:0009074)	2.69894851
74	regulation of neurotransmitter uptake (GO:0051580)	2.68530449
75	regulation of DNA endoreduplication (GO:0032875)	2.65472775
76	retinal cone cell development (GO:0046549)	2.63476311
77	meiotic nuclear division (GO:0007126)	2.61848336
78	tachykinin receptor signaling pathway (GO:0007217)	2.61351504
79	acrosome reaction (GO:0007340)	2.61107758
80	NAD biosynthetic process (GO:0009435)	2.58654272
81	polyol catabolic process (GO:0046174)	2.58377373
82	single fertilization (GO:0007338)	2.54698563
83	reproduction (GO:0000003)	2.52997639
84	positive regulation of fatty acid transport (GO:2000193)	2.52823870
85	cyclic nucleotide catabolic process (GO:0009214)	2.52690523
86	pseudouridine synthesis (GO:0001522)	2.51529898
87	protein K63-linked deubiquitination (GO:0070536)	2.46223753
88	spermatid development (GO:0007286)	2.45412317
89	ketone body metabolic process (GO:1902224)	2.45095605
90	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44292109
91	neuronal action potential (GO:0019228)	2.43975162
92	regulation of hexokinase activity (GO:1903299)	2.43964239
93	regulation of glucokinase activity (GO:0033131)	2.43964239
94	protein polyglutamylation (GO:0018095)	2.42915008
95	oxidative demethylation (GO:0070989)	2.42108700
96	hindbrain development (GO:0030902)	2.41356330
97	regulation of centriole replication (GO:0046599)	2.40233973
98	regulation of meiotic cell cycle (GO:0051445)	2.39656693
99	regulation of defense response to virus by host (GO:0050691)	2.37924378
100	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.37501965

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.97309729
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64803729
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.28101679
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17499213
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.06880874
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.88312599
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52486452
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.49012068
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44974334
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39539758
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34383350
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26029125
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23929427
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.18041389
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15738119
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02222001
17	P300_19829295_ChIP-Seq_ESCs_Human	2.00229534
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95448697
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94801277
20	EWS_26573619_Chip-Seq_HEK293_Human	1.93220430
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92300187
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86852244
23	FUS_26573619_Chip-Seq_HEK293_Human	1.84016161
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72200882
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71531915
26	* TCF4_23295773_ChIP-Seq_U87_Human	1.68263295
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67344355
28	STAT3_23295773_ChIP-Seq_U87_Human	1.64790555
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64375582
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63814360
31	AR_25329375_ChIP-Seq_VCAP_Human	1.62893444
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59605639
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59573205
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59441640
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.58970652
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.58800421
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58203524
38	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57395118
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56671967
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56277484
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.55161953
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54585683
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.54585683
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49531840
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49023388
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47986414
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46416781
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.46045644
49	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.45245758
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43592934
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.41532574
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40736297
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.40268574
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.40150139
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37271669
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36792977
57	NCOR_22424771_ChIP-Seq_293T_Human	1.35904241
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.34652745
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33475629
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33062165
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32320210
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31704510
63	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31646544
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28327093
65	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27866065
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26746213
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26354566
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24357402
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19984370
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17784394
71	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.14196793
72	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.14196793
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12640199
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10564132
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10063608
76	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09009350
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08873347
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06627351
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06312387
80	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06181816
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05870199
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05870199
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05699755
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04591869
85	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03969781
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03742830
87	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02974936
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01740013
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01594868
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01389530
91	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.99842718
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99510360
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99309998
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99239252
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99239252
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98601157
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97783583
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97278134
99	AR_20517297_ChIP-Seq_VCAP_Human	0.96824010
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96646786

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.75781660
2	MP0008877_abnormal_DNA_methylation	3.43169168
3	MP0003283_abnormal_digestive_organ	3.15355782
4	MP0003136_yellow_coat_color	2.89752847
5	MP0002102_abnormal_ear_morphology	2.66822774
6	MP0000427_abnormal_hair_cycle	2.40251264
7	MP0002160_abnormal_reproductive_system	2.26164278
8	MP0003195_calcinosis	2.17374739
9	MP0008872_abnormal_physiological_respon	2.10655177
10	MP0003718_maternal_effect	2.04907391
11	MP0005551_abnormal_eye_electrophysiolog	2.02449735
12	MP0006276_abnormal_autonomic_nervous	2.02267318
13	MP0002837_dystrophic_cardiac_calcinosis	1.98488540
14	MP0000372_irregular_coat_pigmentation	1.94080444
15	MP0002163_abnormal_gland_morphology	1.92201077
16	MP0002876_abnormal_thyroid_physiology	1.89126756
17	MP0009046_muscle_twitch	1.86612406
18	MP0008058_abnormal_DNA_repair	1.84518703
19	MP0004142_abnormal_muscle_tone	1.81079732
20	MP0000569_abnormal_digit_pigmentation	1.80098671
21	MP0005645_abnormal_hypothalamus_physiol	1.79382958
22	MP0003950_abnormal_plasma_membrane	1.74543880
23	MP0000631_abnormal_neuroendocrine_gland	1.73635926
24	MP0001929_abnormal_gametogenesis	1.72897296
25	MP0004043_abnormal_pH_regulation	1.70830275
26	MP0002210_abnormal_sex_determination	1.70658495
27	MP0005646_abnormal_pituitary_gland	1.69918658
28	MP0003787_abnormal_imprinting	1.69800843
29	MP0001968_abnormal_touch/_nociception	1.69200387
30	MP0009745_abnormal_behavioral_response	1.68558405
31	MP0005389_reproductive_system_phenotype	1.64201325
32	MP0005410_abnormal_fertilization	1.60981885
33	MP0001986_abnormal_taste_sensitivity	1.58823301
34	MP0005379_endocrine/exocrine_gland_phen	1.56848818
35	MP0002272_abnormal_nervous_system	1.55250046
36	MP0002138_abnormal_hepatobiliary_system	1.53673252
37	MP0006072_abnormal_retinal_apoptosis	1.53223474
38	MP0002653_abnormal_ependyma_morphology	1.52135305
39	MP0003646_muscle_fatigue	1.51101618
40	MP0002751_abnormal_autonomic_nervous	1.46354359
41	MP0003119_abnormal_digestive_system	1.40692277
42	MP0002736_abnormal_nociception_after	1.39439429
43	MP0004147_increased_porphyrin_level	1.35796535
44	MP0004742_abnormal_vestibular_system	1.33375525
45	MP0003698_abnormal_male_reproductive	1.29367680
46	MP0004885_abnormal_endolymph	1.29275102
47	MP0005253_abnormal_eye_physiology	1.26992227
48	MP0005084_abnormal_gallbladder_morpholo	1.24197930
49	MP0000653_abnormal_sex_gland	1.22935977
50	MP0003693_abnormal_embryo_hatching	1.21933834
51	MP0003890_abnormal_embryonic-extraembry	1.20611524
52	MP0002234_abnormal_pharynx_morphology	1.17926234
53	MP0002638_abnormal_pupillary_reflex	1.17809150
54	MP0000049_abnormal_middle_ear	1.17647470
55	MP0001485_abnormal_pinna_reflex	1.17542468
56	MP0004133_heterotaxia	1.16187988
57	MP0001502_abnormal_circadian_rhythm	1.15771117
58	MP0003121_genomic_imprinting	1.14262585
59	MP0002938_white_spotting	1.13668124
60	MP0008875_abnormal_xenobiotic_pharmacok	1.12795060
61	MP0001486_abnormal_startle_reflex	1.12436205
62	MP0002693_abnormal_pancreas_physiology	1.11245080
63	MP0001145_abnormal_male_reproductive	1.09703802
64	MP0002184_abnormal_innervation	1.08953403
65	MP0003880_abnormal_central_pattern	1.08573993
66	MP0002557_abnormal_social/conspecific_i	1.08000532
67	MP0000230_abnormal_systemic_arterial	1.04029300
68	MP0001293_anophthalmia	1.02166223
69	MP0005174_abnormal_tail_pigmentation	1.02100383
70	MP0000678_abnormal_parathyroid_gland	1.01341700
71	MP0008995_early_reproductive_senescence	1.01335725
72	MP0005220_abnormal_exocrine_pancreas	1.00850214
73	MP0001664_abnormal_digestion	1.00813074
74	MP0002067_abnormal_sensory_capabilities	0.98777187
75	MP0000015_abnormal_ear_pigmentation	0.98084190
76	MP0001905_abnormal_dopamine_level	0.97693819
77	MP0001944_abnormal_pancreas_morphology	0.96663487
78	MP0000778_abnormal_nervous_system	0.96504019
79	MP0000647_abnormal_sebaceous_gland	0.96276924
80	MP0001119_abnormal_female_reproductive	0.95211379
81	MP0002095_abnormal_skin_pigmentation	0.95001470
82	MP0002572_abnormal_emotion/affect_behav	0.94718552
83	MP0003635_abnormal_synaptic_transmissio	0.94288407
84	MP0000470_abnormal_stomach_morphology	0.93649192
85	MP0003938_abnormal_ear_development	0.93455551
86	MP0001919_abnormal_reproductive_system	0.90559716
87	MP0002277_abnormal_respiratory_mucosa	0.89903218
88	MP0002064_seizures	0.87741502
89	MP0002229_neurodegeneration	0.87673612
90	MP0005195_abnormal_posterior_eye	0.86813665
91	MP0001501_abnormal_sleep_pattern	0.84785246
92	MP0005075_abnormal_melanosome_morpholog	0.84330559
93	MP0003699_abnormal_female_reproductive	0.81501966
94	MP0002063_abnormal_learning/memory/cond	0.80681128
95	MP0004134_abnormal_chest_morphology	0.79615497
96	MP0001529_abnormal_vocalization	0.77463625
97	MP0001440_abnormal_grooming_behavior	0.76612392
98	MP0010094_abnormal_chromosome_stability	0.74645620
99	MP0005360_urolithiasis	0.74127812
100	MP0002161_abnormal_fertility/fecundity	0.73699593

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.17643635
2	Molar tooth sign on MRI (HP:0002419)	3.84709312
3	Abnormality of midbrain morphology (HP:0002418)	3.84709312
4	Pancreatic cysts (HP:0001737)	3.67298253
5	Abnormality of the labia minora (HP:0012880)	3.58398543
6	True hermaphroditism (HP:0010459)	3.28026937
7	Oligodactyly (hands) (HP:0001180)	3.20156504
8	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.00574469
9	Abnormality of alanine metabolism (HP:0010916)	3.00574469
10	Hyperalaninemia (HP:0003348)	3.00574469
11	Nephronophthisis (HP:0000090)	2.96621217
12	Type II lissencephaly (HP:0007260)	2.91622348
13	Abnormality of the renal cortex (HP:0011035)	2.88419867
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.79097747
15	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.76063857
16	Chronic hepatic failure (HP:0100626)	2.69686977
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65923554
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.61538377
19	Medial flaring of the eyebrow (HP:0010747)	2.59880109
20	Disproportionate short-trunk short stature (HP:0003521)	2.57503078
21	Abnormality of the renal medulla (HP:0100957)	2.54579739
22	Abnormality of the pons (HP:0007361)	2.51828911
23	Attenuation of retinal blood vessels (HP:0007843)	2.51010735
24	Pendular nystagmus (HP:0012043)	2.50765517
25	Hypoplasia of the fovea (HP:0007750)	2.49106441
26	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.49106441
27	Abolished electroretinogram (ERG) (HP:0000550)	2.46082543
28	Gaze-evoked nystagmus (HP:0000640)	2.41964468
29	Congenital sensorineural hearing impairment (HP:0008527)	2.40649460
30	Congenital stationary night blindness (HP:0007642)	2.38270579
31	Adrenal hypoplasia (HP:0000835)	2.36865270
32	Short tibia (HP:0005736)	2.34544842
33	Tubular atrophy (HP:0000092)	2.34311001
34	Abnormality of the fovea (HP:0000493)	2.33955016
35	Abnormal drinking behavior (HP:0030082)	2.32704236
36	Polydipsia (HP:0001959)	2.32704236
37	Sclerocornea (HP:0000647)	2.31249343
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.30935462
39	Hypoplasia of the pons (HP:0012110)	2.30257008
40	Limb dystonia (HP:0002451)	2.29459129
41	Median cleft lip (HP:0000161)	2.23656846
42	Postaxial foot polydactyly (HP:0001830)	2.22895202
43	Congenital, generalized hypertrichosis (HP:0004540)	2.19562471
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.19510271
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.18322108
46	Aplasia/Hypoplasia of the patella (HP:0006498)	2.17187379
47	Metaphyseal dysplasia (HP:0100255)	2.16994957
48	Cystic liver disease (HP:0006706)	2.16958357
49	Patellar aplasia (HP:0006443)	2.16221561
50	Acute necrotizing encephalopathy (HP:0006965)	2.15233046
51	Keratoconus (HP:0000563)	2.13202116
52	Increased corneal curvature (HP:0100692)	2.13202116
53	Optic nerve hypoplasia (HP:0000609)	2.12734420
54	Ketoacidosis (HP:0001993)	2.12429191
55	Mitochondrial inheritance (HP:0001427)	2.11683846
56	Increased CSF lactate (HP:0002490)	2.10202082
57	Oligodactyly (HP:0012165)	2.07668213
58	Lipid accumulation in hepatocytes (HP:0006561)	2.07497006
59	Renal cortical cysts (HP:0000803)	2.05307630
60	Abnormality of lateral ventricle (HP:0030047)	2.03704480
61	3-Methylglutaconic aciduria (HP:0003535)	2.00074359
62	Bilateral microphthalmos (HP:0007633)	1.99940157
63	Increased hepatocellular lipid droplets (HP:0006565)	1.99932533
64	Decreased circulating renin level (HP:0003351)	1.99057444
65	Retinal dysplasia (HP:0007973)	1.97614337
66	Gait imbalance (HP:0002141)	1.96672627
67	Premature ovarian failure (HP:0008209)	1.95281776
68	Clubbing of toes (HP:0100760)	1.94790164
69	Atonic seizures (HP:0010819)	1.94773557
70	Absent/shortened dynein arms (HP:0200106)	1.94390944
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94390944
72	Fair hair (HP:0002286)	1.94292231
73	Preaxial hand polydactyly (HP:0001177)	1.93023390
74	Congenital primary aphakia (HP:0007707)	1.91808628
75	Ectopic kidney (HP:0000086)	1.91401368
76	Genital tract atresia (HP:0001827)	1.90805697
77	Progressive macrocephaly (HP:0004481)	1.89819328
78	Ketosis (HP:0001946)	1.89580003
79	Cerebellar dysplasia (HP:0007033)	1.89507682
80	Meckel diverticulum (HP:0002245)	1.87781957
81	Conical tooth (HP:0000698)	1.87730422
82	Decreased central vision (HP:0007663)	1.87534842
83	Progressive inability to walk (HP:0002505)	1.85550365
84	Concave nail (HP:0001598)	1.85487680
85	Abnormality of the ileum (HP:0001549)	1.84861098
86	Pachygyria (HP:0001302)	1.83505910
87	Congenital hepatic fibrosis (HP:0002612)	1.83234830
88	Nephrogenic diabetes insipidus (HP:0009806)	1.82840212
89	Large for gestational age (HP:0001520)	1.81832070
90	Abnormality of chromosome stability (HP:0003220)	1.81813624
91	Postaxial hand polydactyly (HP:0001162)	1.80339342
92	Tachypnea (HP:0002789)	1.78801038
93	Inability to walk (HP:0002540)	1.78629262
94	Abnormality of urine glucose concentration (HP:0011016)	1.77270862
95	Glycosuria (HP:0003076)	1.77270862
96	Anencephaly (HP:0002323)	1.76750000
97	Methylmalonic acidemia (HP:0002912)	1.76711704
98	Renal Fanconi syndrome (HP:0001994)	1.76145055
99	Increased serum lactate (HP:0002151)	1.74073768
100	Febrile seizures (HP:0002373)	1.74026053

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.09378671
2	TLK1	4.14487063
3	ZAK	3.11011977
4	ADRBK2	2.87399064
5	NUAK1	2.79715664
6	BMPR1B	2.78851322
7	MAP4K2	2.58660562
8	STK39	2.30436850
9	STK16	2.29870630
10	WNK4	2.26023899
11	GRK1	2.15949515
12	TAOK3	2.04028948
13	ACVR1B	1.99803327
14	PINK1	1.97095910
15	TNIK	1.94647893
16	PLK4	1.89239257
17	MAPK13	1.85022835
18	INSRR	1.82568567
19	VRK1	1.75051381
20	DAPK2	1.59326844
21	NTRK3	1.58367766
22	VRK2	1.52436142
23	OXSR1	1.48482648
24	MAP3K4	1.45001595
25	TRIM28	1.37406496
26	WNK3	1.31550247
27	MAP2K7	1.26259780
28	EPHA4	1.21806562
29	PLK2	1.21798624
30	TEC	1.13681418
31	CSNK1G1	1.11305444
32	NLK	1.08486682
33	PKN1	1.02632017
34	STK3	0.96675647
35	AURKA	0.89555889
36	STK38L	0.88795356
37	BUB1	0.87912956
38	PDK2	0.85672603
39	CSNK1G2	0.84990543
40	WNK1	0.84704903
41	DYRK2	0.84604594
42	MST4	0.83600129
43	PLK1	0.81413003
44	PLK3	0.80027089
45	PHKG1	0.78496644
46	PHKG2	0.78496644
47	TGFBR1	0.76830639
48	PAK3	0.76537472
49	RPS6KA5	0.75826768
50	ADRBK1	0.74850598
51	CSNK1G3	0.72409972
52	CDK3	0.71524386
53	IRAK1	0.71388849
54	STK24	0.69925093
55	MKNK2	0.69544503
56	PRKCE	0.68507288
57	PIK3CA	0.68262330
58	GRK5	0.65610147
59	NTRK2	0.65063693
60	PNCK	0.63783778
61	CHEK2	0.62697546
62	PTK2B	0.61589369
63	CAMKK2	0.60766103
64	BRSK2	0.60382551
65	PRKCG	0.60201121
66	MAPKAPK5	0.56487984
67	MARK3	0.56209374
68	SGK2	0.55579953
69	PRKCI	0.55381503
70	BCKDK	0.54237592
71	TXK	0.53412625
72	EIF2AK3	0.52443535
73	BCR	0.50986437
74	TTK	0.50863020
75	CAMK2A	0.50809611
76	PRKCQ	0.50359839
77	PRKAA1	0.49714191
78	ATR	0.48452033
79	CDK19	0.47687173
80	CAMK1	0.47441065
81	PRKACA	0.46151335
82	MAP2K6	0.45135724
83	NEK2	0.44589759
84	ATM	0.43969838
85	CASK	0.43518286
86	STK11	0.42085700
87	CSNK1D	0.41374954
88	CDC7	0.38245559
89	PRKG1	0.35911776
90	CSNK1E	0.35847641
91	CSNK1A1	0.35833835
92	MARK1	0.35477663
93	SGK223	0.33717445
94	SGK494	0.33717445
95	FGFR2	0.32450598
96	ILK	0.32410816
97	MAP2K4	0.32330939
98	CDK8	0.32273347
99	AURKB	0.30818098
100	DYRK3	0.27671072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.95231401
2	Butanoate metabolism_Homo sapiens_hsa00650	2.50594125
3	Phototransduction_Homo sapiens_hsa04744	2.47736789
4	Homologous recombination_Homo sapiens_hsa03440	2.47484469
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.45815922
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.41479803
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33059211
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24229800
9	Protein export_Homo sapiens_hsa03060	2.19868978
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16337997
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12612724
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05972723
13	Basal transcription factors_Homo sapiens_hsa03022	2.03870665
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00641032
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.97438579
16	RNA polymerase_Homo sapiens_hsa03020	1.96621934
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.95023463
18	Olfactory transduction_Homo sapiens_hsa04740	1.80998773
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74001252
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60927057
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.59879780
22	Nicotine addiction_Homo sapiens_hsa05033	1.58477920
23	Insulin secretion_Homo sapiens_hsa04911	1.56185607
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.54301400
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52817782
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43012438
27	Morphine addiction_Homo sapiens_hsa05032	1.33826548
28	Parkinsons disease_Homo sapiens_hsa05012	1.31056259
29	RNA degradation_Homo sapiens_hsa03018	1.30715455
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.27908620
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.21756168
32	ABC transporters_Homo sapiens_hsa02010	1.20332753
33	Sulfur metabolism_Homo sapiens_hsa00920	1.20039219
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19567813
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14053357
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12162689
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11446007
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05387743
39	Caffeine metabolism_Homo sapiens_hsa00232	1.04598808
40	Retinol metabolism_Homo sapiens_hsa00830	1.04434047
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03232810
42	Serotonergic synapse_Homo sapiens_hsa04726	1.03114987
43	Fatty acid elongation_Homo sapiens_hsa00062	1.03058689
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02483541
45	GABAergic synapse_Homo sapiens_hsa04727	1.00828149
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99152081
47	Regulation of autophagy_Homo sapiens_hsa04140	0.98732702
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98080719
49	Taste transduction_Homo sapiens_hsa04742	0.97695661
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97293473
51	Huntingtons disease_Homo sapiens_hsa05016	0.92678093
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.92320150
53	Purine metabolism_Homo sapiens_hsa00230	0.91815258
54	RNA transport_Homo sapiens_hsa03013	0.90230628
55	Circadian entrainment_Homo sapiens_hsa04713	0.89240260
56	Cocaine addiction_Homo sapiens_hsa05030	0.88938925
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87541723
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86675036
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.85036980
60	Propanoate metabolism_Homo sapiens_hsa00640	0.81346319
61	Ribosome_Homo sapiens_hsa03010	0.80851276
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80829193
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.79325074
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78954960
65	One carbon pool by folate_Homo sapiens_hsa00670	0.78680693
66	Salivary secretion_Homo sapiens_hsa04970	0.77432913
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76149700
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74466236
69	Bile secretion_Homo sapiens_hsa04976	0.72860933
70	Circadian rhythm_Homo sapiens_hsa04710	0.71919998
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71660020
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68616480
73	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64460923
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63292257
75	Amphetamine addiction_Homo sapiens_hsa05031	0.62971106
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.61861203
77	Oocyte meiosis_Homo sapiens_hsa04114	0.57579211
78	Mismatch repair_Homo sapiens_hsa03430	0.55390532
79	Peroxisome_Homo sapiens_hsa04146	0.54730460
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54722278
81	Alzheimers disease_Homo sapiens_hsa05010	0.52404471
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51456306
83	Metabolic pathways_Homo sapiens_hsa01100	0.49622389
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48422935
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46961738
86	Mineral absorption_Homo sapiens_hsa04978	0.45342093
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.43045845
88	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41530215
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41328693
90	Asthma_Homo sapiens_hsa05310	0.41262046
91	Cholinergic synapse_Homo sapiens_hsa04725	0.41207449
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.40895368
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.39602280
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38870445
95	Lysine degradation_Homo sapiens_hsa00310	0.37062739
96	Renin secretion_Homo sapiens_hsa04924	0.34873933
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34142367
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32531005
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31072672
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30681318

FRG2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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