FRG2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)8.50942420
2synaptonemal complex organization (GO:0070193)6.78510082
3histone lysine demethylation (GO:0070076)6.65649316
4synaptonemal complex assembly (GO:0007130)6.64384329
5regulation of exit from mitosis (GO:0007096)6.38316437
6regulation of RIG-I signaling pathway (GO:0039535)6.33810536
7histone demethylation (GO:0016577)6.27233772
8positive regulation of meiosis (GO:0045836)6.09790860
9multicellular organism reproduction (GO:0032504)5.95417258
10positive regulation of meiotic cell cycle (GO:0051446)5.75589469
11negative regulation of Ras GTPase activity (GO:0034261)5.66051920
12protein demethylation (GO:0006482)5.65952279
13protein dealkylation (GO:0008214)5.65952279
14gonadal mesoderm development (GO:0007506)5.57890788
15regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.54073449
16N-terminal protein amino acid acetylation (GO:0006474)5.47951410
17regulation of alternative mRNA splicing, via spliceosome (GO:0000381)5.33457865
18single fertilization (GO:0007338)4.77260224
19chromosome organization involved in meiosis (GO:0070192)4.71971014
20male meiosis I (GO:0007141)4.68784346
21regulation of acrosome reaction (GO:0060046)4.64020082
22response to UV-C (GO:0010225)4.53620946
23protein K48-linked deubiquitination (GO:0071108)4.44693176
24male meiosis (GO:0007140)4.41940512
25positive regulation of catecholamine secretion (GO:0033605)4.39164857
26acrosome reaction (GO:0007340)4.32330323
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.20884388
28positive regulation of uterine smooth muscle contraction (GO:0070474)4.20355569
29positive regulation of histone H3-K4 methylation (GO:0051571)4.15367026
30regulation of female receptivity (GO:0045924)4.13875613
31centriole replication (GO:0007099)4.08991022
32regulation of histone H3-K9 methylation (GO:0051570)4.04816376
33regulation of DNA endoreduplication (GO:0032875)3.91400836
34reproduction (GO:0000003)3.89596480
35meiosis I (GO:0007127)3.88176924
36intestinal epithelial cell development (GO:0060576)3.87144494
37regulation of defense response to virus by host (GO:0050691)3.81869946
38regulation of helicase activity (GO:0051095)3.74435406
39positive regulation of humoral immune response (GO:0002922)3.73179383
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.70265389
41protein K6-linked ubiquitination (GO:0085020)3.69051074
42protein K63-linked deubiquitination (GO:0070536)3.61667777
43female mating behavior (GO:0060180)3.60610264
44fertilization (GO:0009566)3.53831702
45regulation of meiosis (GO:0040020)3.48865907
46binding of sperm to zona pellucida (GO:0007339)3.45530378
47meiotic cell cycle process (GO:1903046)3.38735769
48regulation of mRNA splicing, via spliceosome (GO:0048024)3.36106629
49regulation of ruffle assembly (GO:1900027)3.35653786
50meiotic cell cycle (GO:0051321)3.32678764
51piRNA metabolic process (GO:0034587)3.31852038
52poly(A)+ mRNA export from nucleus (GO:0016973)3.28807903
53RNA localization (GO:0006403)3.25679167
54negative regulation of histone modification (GO:0031057)3.16362311
55response to lipoprotein particle (GO:0055094)3.11036468
56regulation of uterine smooth muscle contraction (GO:0070472)3.09562116
57epithelial cilium movement (GO:0003351)3.04997527
58regulation of female gonad development (GO:2000194)3.03787650
59mitotic metaphase plate congression (GO:0007080)3.03481425
60DNA replication-dependent nucleosome assembly (GO:0006335)3.03192586
61DNA replication-dependent nucleosome organization (GO:0034723)3.03192586
62striated muscle atrophy (GO:0014891)2.99805060
63pancreas development (GO:0031016)2.97776673
64cilium movement (GO:0003341)2.97218345
65regulation of mRNA processing (GO:0050684)2.95863891
66tryptophan catabolic process (GO:0006569)2.94032209
67indole-containing compound catabolic process (GO:0042436)2.94032209
68indolalkylamine catabolic process (GO:0046218)2.94032209
69aggressive behavior (GO:0002118)2.93333394
70positive regulation of DNA-dependent DNA replication (GO:2000105)2.91513819
71centrosome duplication (GO:0051298)2.89959360
72calcium ion-dependent exocytosis (GO:0017156)2.89487462
73demethylation (GO:0070988)2.89337370
74negative regulation of chromatin modification (GO:1903309)2.89309581
75maturation of SSU-rRNA (GO:0030490)2.88797460
76mitochondrial RNA metabolic process (GO:0000959)2.88645896
77sperm-egg recognition (GO:0035036)2.87767234
78regulation of meiotic cell cycle (GO:0051445)2.86978268
79N-terminal protein amino acid modification (GO:0031365)2.85790767
80regulation of receptor binding (GO:1900120)2.85149951
81organ formation (GO:0048645)2.85018736
82intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.84513131
83natural killer cell differentiation (GO:0001779)2.84269687
84citrulline biosynthetic process (GO:0019240)2.84104796
85positive regulation of skeletal muscle tissue development (GO:0048643)2.82420050
86negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.82294955
87positive regulation of prostaglandin secretion (GO:0032308)2.80843593
88negative regulation of smooth muscle cell differentiation (GO:0051151)2.79951885
89negative regulation of digestive system process (GO:0060457)2.77764152
90telomere maintenance via telomerase (GO:0007004)2.76454378
91vitamin catabolic process (GO:0009111)2.76187568
92fat-soluble vitamin catabolic process (GO:0042363)2.76187568
93pyrimidine dimer repair (GO:0006290)2.75791984
94spermatid development (GO:0007286)2.75151962
95kynurenine metabolic process (GO:0070189)2.74654586
96microtubule severing (GO:0051013)2.74434921
97protein kinase C signaling (GO:0070528)2.71908509
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.70468459
99regulation of centriole replication (GO:0046599)2.70003125
100histone H3-K9 demethylation (GO:0033169)17.2008415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.61985267
2EZH2_22144423_ChIP-Seq_EOC_Human5.78058509
3VDR_22108803_ChIP-Seq_LS180_Human4.23390420
4E2F7_22180533_ChIP-Seq_HELA_Human4.07165305
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.82702348
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.51016474
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.36780575
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08231664
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80872083
10IGF1R_20145208_ChIP-Seq_DFB_Human2.78845252
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.59563967
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57908143
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52349291
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.37885926
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23255291
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.22738645
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07026564
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05386492
19GBX2_23144817_ChIP-Seq_PC3_Human1.98881851
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96741990
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96220297
22IRF1_19129219_ChIP-ChIP_H3396_Human1.89347571
23AUTS2_25519132_ChIP-Seq_293T-REX_Human1.89263118
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86063210
25TCF4_23295773_ChIP-Seq_U87_Human1.77417104
26PRDM14_20953172_ChIP-Seq_ESCs_Human1.77357373
27MYC_18940864_ChIP-ChIP_HL60_Human1.75872992
28CBP_21632823_ChIP-Seq_H3396_Human1.73335192
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70373116
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67227288
31RXR_22108803_ChIP-Seq_LS180_Human1.60746631
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59277637
33SMRT_27268052_Chip-Seq_Bcells_Human1.49241392
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48744044
35AR_25329375_ChIP-Seq_VCAP_Human1.48293263
36TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.48196636
37RNF2_27304074_Chip-Seq_NSC_Mouse1.44407452
38STAT3_23295773_ChIP-Seq_U87_Human1.42031343
39P300_19829295_ChIP-Seq_ESCs_Human1.41860592
40TAF15_26573619_Chip-Seq_HEK293_Human1.40426054
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.38153404
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37298078
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35684353
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35038449
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34585198
46SMAD4_21799915_ChIP-Seq_A2780_Human1.33475676
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31177989
48SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30282693
49TCF4_22108803_ChIP-Seq_LS180_Human1.29327892
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27854524
51NCOR_22424771_ChIP-Seq_293T_Human1.26510960
52GF1_26923725_Chip-Seq_HPCs_Mouse1.24699398
53AR_21909140_ChIP-Seq_LNCAP_Human1.22835689
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22053609
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20950710
56TTF2_22483619_ChIP-Seq_HELA_Human1.19926194
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19660764
58* GATA3_26560356_Chip-Seq_TH1_Human1.19508273
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18231571
60BCAT_22108803_ChIP-Seq_LS180_Human1.17661216
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16698513
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16060715
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14904400
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14797981
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14003471
66FOXP3_21729870_ChIP-Seq_TREG_Human1.13571669
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13501713
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12096954
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.11872406
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.11140813
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.10840439
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.10513517
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.08467759
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.07861113
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.06249229
76TP53_22573176_ChIP-Seq_HFKS_Human1.05369871
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04319199
78RAC3_21632823_ChIP-Seq_H3396_Human1.02822444
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.01144902
80RUNX2_22187159_ChIP-Seq_PCA_Human1.01003964
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00673792
82STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99442208
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99364614
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98216190
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.97164259
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95815420
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94328369
88ESET_19884257_ChIP-Seq_ESCs_Mouse0.93765331
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.92754734
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91563830
91CBP_20019798_ChIP-Seq_JUKART_Human0.91563830
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.90674003
93EWS_26573619_Chip-Seq_HEK293_Human0.90008191
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88780838
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88425062
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.88108599
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87159900
98VDR_23849224_ChIP-Seq_CD4+_Human0.86732177
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86724388
100P300_27268052_Chip-Seq_Bcells_Human0.83751145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.91817224
2MP0006292_abnormal_olfactory_placode5.80792498
3MP0003950_abnormal_plasma_membrane3.91144514
4MP0003693_abnormal_embryo_hatching3.78108224
5MP0009379_abnormal_foot_pigmentation3.57726334
6MP0000678_abnormal_parathyroid_gland3.48514467
7MP0002160_abnormal_reproductive_system3.30998078
8MP0008058_abnormal_DNA_repair3.09985121
9MP0010094_abnormal_chromosome_stability2.81340067
10MP0000427_abnormal_hair_cycle2.72340540
11MP0005410_abnormal_fertilization2.49106266
12MP0003136_yellow_coat_color2.44574310
13MP0001929_abnormal_gametogenesis2.34039324
14MP0002751_abnormal_autonomic_nervous2.19077484
15MP0002210_abnormal_sex_determination2.10601505
16MP0005220_abnormal_exocrine_pancreas2.07127765
17MP0000372_irregular_coat_pigmentation1.93550910
18MP0006276_abnormal_autonomic_nervous1.89613386
19MP0003077_abnormal_cell_cycle1.85743166
20MP0003866_abnormal_defecation1.80940287
21MP0009840_abnormal_foam_cell1.77414645
22MP0005389_reproductive_system_phenotype1.75553985
23MP0001666_abnormal_nutrient_absorption1.73185900
24MP0000685_abnormal_immune_system1.72917745
25MP0001664_abnormal_digestion1.72853013
26MP0001502_abnormal_circadian_rhythm1.68706598
27MP0003699_abnormal_female_reproductive1.65480144
28MP0006072_abnormal_retinal_apoptosis1.61238330
29MP0000049_abnormal_middle_ear1.60203682
30MP0005360_urolithiasis1.59652692
31MP0003119_abnormal_digestive_system1.57608344
32MP0005076_abnormal_cell_differentiation1.57051736
33MP0003868_abnormal_feces_composition1.53683085
34MP0004381_abnormal_hair_follicle1.52276607
35MP0001986_abnormal_taste_sensitivity1.50581996
36MP0002396_abnormal_hematopoietic_system1.49757714
37MP0004043_abnormal_pH_regulation1.45664887
38MP0000653_abnormal_sex_gland1.42894085
39MP0003890_abnormal_embryonic-extraembry1.38113091
40MP0003111_abnormal_nucleus_morphology1.33590253
41MP0005645_abnormal_hypothalamus_physiol1.31793556
42MP0005647_abnormal_sex_gland1.31663828
43MP0004233_abnormal_muscle_weight1.31253452
44MP0008877_abnormal_DNA_methylation1.27056720
45MP0003698_abnormal_male_reproductive1.25872337
46MP0001119_abnormal_female_reproductive1.21799122
47MP0010307_abnormal_tumor_latency1.21726184
48MP0001730_embryonic_growth_arrest1.20458612
49MP0001145_abnormal_male_reproductive1.18475896
50MP0005646_abnormal_pituitary_gland1.17842035
51MP0003183_abnormal_peptide_metabolism1.15162904
52MP0000631_abnormal_neuroendocrine_gland1.14023393
53MP0000470_abnormal_stomach_morphology1.13383816
54MP0005423_abnormal_somatic_nervous1.07658443
55MP0000350_abnormal_cell_proliferation1.04877137
56MP0002161_abnormal_fertility/fecundity1.03790526
57MP0003938_abnormal_ear_development1.03748531
58MP0005075_abnormal_melanosome_morpholog0.98948452
59MP0005310_abnormal_salivary_gland0.96778497
60MP0003718_maternal_effect0.96022776
61MP0002102_abnormal_ear_morphology0.94993697
62MP0003936_abnormal_reproductive_system0.94377644
63MP0001501_abnormal_sleep_pattern0.91941530
64MP0002332_abnormal_exercise_endurance0.90081268
65MP0002090_abnormal_vision0.89502452
66MP0003763_abnormal_thymus_physiology0.89433161
67MP0000462_abnormal_digestive_system0.85019231
68MP0005253_abnormal_eye_physiology0.83317096
69MP0001944_abnormal_pancreas_morphology0.82680201
70MP0001286_abnormal_eye_development0.81640956
71MP0002876_abnormal_thyroid_physiology0.79168094
72MP0002095_abnormal_skin_pigmentation0.76905085
73MP0002138_abnormal_hepatobiliary_system0.76176335
74MP0002184_abnormal_innervation0.73691145
75MP0002277_abnormal_respiratory_mucosa0.73456359
76MP0005623_abnormal_meninges_morphology0.71504038
77MP0008057_abnormal_DNA_replication0.70525400
78MP0005551_abnormal_eye_electrophysiolog0.69938063
79MP0000230_abnormal_systemic_arterial0.68836932
80MP0001293_anophthalmia0.68110746
81MP0003959_abnormal_lean_body0.68083996
82MP0003121_genomic_imprinting0.67827742
83MP0002693_abnormal_pancreas_physiology0.66916564
84MP0003786_premature_aging0.65768927
85MP0002229_neurodegeneration0.63332371
86MP0002272_abnormal_nervous_system0.63232849
87MP0000465_gastrointestinal_hemorrhage0.62697915
88MP0009765_abnormal_xenobiotic_induced0.61875597
89MP0004742_abnormal_vestibular_system0.61697221
90MP0002019_abnormal_tumor_incidence0.60438684
91MP0004134_abnormal_chest_morphology0.57302785
92MP0002249_abnormal_larynx_morphology0.57102121
93MP0000534_abnormal_ureter_morphology0.56983415
94MP0002163_abnormal_gland_morphology0.56796909
95MP0004957_abnormal_blastocyst_morpholog0.56565138
96MP0001440_abnormal_grooming_behavior0.54495592
97MP0000689_abnormal_spleen_morphology0.52922941
98MP0009384_cardiac_valve_regurgitation0.50466928
99MP0000428_abnormal_craniofacial_morphol0.49494948
100MP0003879_abnormal_hair_cell0.47667357

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)7.09644391
2Median cleft lip (HP:0000161)4.51659656
3Microglossia (HP:0000171)4.06099011
4Oligodactyly (hands) (HP:0001180)3.98606386
5Short tibia (HP:0005736)3.97903561
6Aplasia/Hypoplasia of the tibia (HP:0005772)3.93240409
7Abnormal number of incisors (HP:0011064)3.86281589
8Atonic seizures (HP:0010819)3.80488956
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.60562217
10Impulsivity (HP:0100710)3.51052020
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.44453889
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.44453889
13Prostate neoplasm (HP:0100787)3.34380388
14Hyperphosphatemia (HP:0002905)3.22030686
15Abnormal auditory evoked potentials (HP:0006958)3.18654134
16Abnormality of the nasal septum (HP:0000419)3.12361055
17Chromsome breakage (HP:0040012)3.11670536
18Congenital sensorineural hearing impairment (HP:0008527)3.08507991
19Abnormality of chromosome stability (HP:0003220)3.06891114
20Short chin (HP:0000331)3.04373654
21Agammaglobulinemia (HP:0004432)3.01235509
22Adrenal hypoplasia (HP:0000835)2.96052104
23Tetany (HP:0001281)2.94488733
24Facial cleft (HP:0002006)2.91193883
25Abnormality of the corticospinal tract (HP:0002492)2.82601861
26Amelogenesis imperfecta (HP:0000705)2.81763523
27Reticulocytopenia (HP:0001896)2.79035176
28Ectopic kidney (HP:0000086)2.67650718
29Poikiloderma (HP:0001029)2.62221090
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62030390
31Chronic sinusitis (HP:0011109)2.61500721
32Oligodactyly (HP:0012165)2.60211114
33Metaphyseal dysplasia (HP:0100255)2.57512751
34Abnormality of the labia minora (HP:0012880)2.50819919
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.50493644
36Recurrent bronchitis (HP:0002837)2.45851280
37Submucous cleft hard palate (HP:0000176)2.41527207
38Meckel diverticulum (HP:0002245)2.41048058
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40259926
40Pancreatic fibrosis (HP:0100732)2.40060702
41Autoimmune thrombocytopenia (HP:0001973)2.37629128
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.35098780
43Abnormality of the ileum (HP:0001549)2.34482350
44Microretrognathia (HP:0000308)2.32880711
45Tetraparesis (HP:0002273)2.30951216
46Abnormality of lateral ventricle (HP:0030047)2.28563324
47Absence seizures (HP:0002121)2.28523382
48Abnormality of dental color (HP:0011073)2.25559106
49Absent thumb (HP:0009777)2.23998066
50Maternal diabetes (HP:0009800)2.22148765
51Abnormality of abdominal situs (HP:0011620)2.17133043
52Abdominal situs inversus (HP:0003363)2.17133043
53Clubbing of toes (HP:0100760)2.16583604
54Abnormality of the frontal sinuses (HP:0002687)2.14174117
55Genu varum (HP:0002970)2.12592908
56Autoimmune hemolytic anemia (HP:0001890)2.11691408
57Abnormality of the preputium (HP:0100587)2.11433299
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.11070900
59Exertional dyspnea (HP:0002875)2.10765511
60Mitochondrial inheritance (HP:0001427)2.07626478
61Increased CSF lactate (HP:0002490)2.07616291
62Duodenal stenosis (HP:0100867)2.06587218
63Small intestinal stenosis (HP:0012848)2.06587218
64Abnormality of the incisor (HP:0000676)2.06306477
65Disproportionate short-trunk short stature (HP:0003521)2.05993544
66Diastasis recti (HP:0001540)2.03452821
67Anhidrosis (HP:0000970)2.01101358
68Dialeptic seizures (HP:0011146)1.98840943
69Increased hepatocellular lipid droplets (HP:0006565)1.97931892
70Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95454622
71Supernumerary spleens (HP:0009799)1.93835273
72Neoplasm of the adrenal cortex (HP:0100641)1.93039059
73Acute necrotizing encephalopathy (HP:0006965)1.92831967
74Abnormal ciliary motility (HP:0012262)1.91716768
75Loss of speech (HP:0002371)1.91070601
76Short thumb (HP:0009778)1.90918353
77Facial hemangioma (HP:0000329)1.90462129
78Bronchitis (HP:0012387)1.89390671
79Sandal gap (HP:0001852)1.88885736
80Type I diabetes mellitus (HP:0100651)1.87705466
81Glossoptosis (HP:0000162)1.83625034
82B lymphocytopenia (HP:0010976)1.83095170
83Abnormality of the epiphyses of the hand (HP:0005924)1.82942153
84Abnormality of DNA repair (HP:0003254)1.81119429
85Osteomyelitis (HP:0002754)1.79660269
86Partial agenesis of the corpus callosum (HP:0001338)1.78016033
87Abnormal pancreas size (HP:0012094)1.77907482
88Volvulus (HP:0002580)1.76674502
89Hypoplasia of the radius (HP:0002984)1.76471145
90Oligomenorrhea (HP:0000876)1.73951454
91Hypoplasia of the iris (HP:0007676)1.73871944
92Fair hair (HP:0002286)1.72948827
93Sensory axonal neuropathy (HP:0003390)1.72520477
94Apathy (HP:0000741)1.71618481
95Renal Fanconi syndrome (HP:0001994)1.70119798
96Rhinitis (HP:0012384)1.68117202
97Hypoproteinemia (HP:0003075)1.67533741
98Abnormal mitochondria in muscle tissue (HP:0008316)1.66620353
99Abnormality of B cell number (HP:0010975)1.66429672
100Neurofibrillary tangles (HP:0002185)1.64672943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.84681559
2STK165.29251521
3TLK14.24597216
4CDK123.45940444
5ICK3.31511918
6PLK43.00754727
7VRK12.62897930
8VRK22.56765184
9TNIK2.54021384
10ZAK2.49028570
11TAOK32.42896948
12CDC72.33066542
13STK392.31488868
14AURKA2.27593516
15SRPK12.26820919
16CDK192.18938657
17BMPR1B1.99101403
18GRK11.93327792
19MAP3K101.92851015
20NLK1.80016474
21BUB11.61667308
22ACVR1B1.54125882
23NUAK11.51592517
24TEC1.35186326
25MAPKAPK31.29893423
26TTK1.27635860
27TRIM281.25500930
28CHEK21.24025890
29MAP2K31.18415941
30WNK11.11610024
31ARAF1.11177835
32AURKB1.09777267
33MELK1.08831936
34CDK81.01787606
35CDK70.98215764
36LATS20.90221254
37WNK40.88676412
38PLK10.86890559
39SGK20.86749078
40PLK20.83239596
41OXSR10.81361953
42EPHA40.77878396
43TGFBR10.77824811
44PBK0.76833168
45PIK3CG0.73886741
46EIF2AK30.72633038
47MARK20.70360285
48GRK70.69260605
49RAF10.68941377
50MAPK110.68598362
51STK240.66808466
52MAPK130.66353337
53PIK3CA0.65001119
54MAPKAPK20.64802950
55PKN10.64732983
56CHEK10.64509164
57CDK40.63044975
58BRAF0.60174943
59PIM10.58078982
60LIMK10.57727897
61ATR0.57400339
62MAP3K30.53738786
63PRKCI0.52903563
64PIM20.49373918
65MARK30.48626305
66CAMK40.44077580
67ERN10.41144904
68RPS6KA50.39255762
69SGK4940.38764439
70SGK2230.38764439
71CDK20.38526094
72ATM0.38161111
73RPS6KB20.36916544
74GRK50.34912923
75PRKD10.34503604
76CSNK1G10.33221719
77CSNK1D0.32591304
78PLK30.32580813
79CDK10.31165171
80CDK90.31020202
81PRKACA0.28222553
82MAPK120.27261233
83STK30.26914177
84DAPK10.25679661
85CSNK1E0.24844972
86RPS6KB10.24689384
87SYK0.24227142
88PRKAA10.22902109
89CAMK1D0.22272841
90CSNK2A10.19706670
91FRK0.19034106
92AKT20.18546141
93CSNK2A20.18105937
94SGK30.17780035
95IRAK40.17711303
96NEK60.17549786
97MAPK40.17386256
98LYN0.17012406
99IRAK10.16947953
100STK100.16785424

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005336.30200924
2Mismatch repair_Homo sapiens_hsa034303.81038716
3Homologous recombination_Homo sapiens_hsa034403.25829943
4Dorso-ventral axis formation_Homo sapiens_hsa043202.98959104
5Ribosome_Homo sapiens_hsa030102.97763066
6Fanconi anemia pathway_Homo sapiens_hsa034602.69234021
7DNA replication_Homo sapiens_hsa030302.67735955
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.55582900
9Phototransduction_Homo sapiens_hsa047442.50447666
10Non-homologous end-joining_Homo sapiens_hsa034502.37898846
11Basal transcription factors_Homo sapiens_hsa030222.36632217
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28954981
13RNA polymerase_Homo sapiens_hsa030202.01420032
14RNA degradation_Homo sapiens_hsa030181.92275309
15Sulfur metabolism_Homo sapiens_hsa009201.89805344
16Bile secretion_Homo sapiens_hsa049761.84026654
17mRNA surveillance pathway_Homo sapiens_hsa030151.73957987
18RNA transport_Homo sapiens_hsa030131.69187277
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.67431826
20Olfactory transduction_Homo sapiens_hsa047401.62677540
21Oocyte meiosis_Homo sapiens_hsa041141.62161830
22Tryptophan metabolism_Homo sapiens_hsa003801.43413386
23Base excision repair_Homo sapiens_hsa034101.42378359
24Cell cycle_Homo sapiens_hsa041101.37142167
25Primary immunodeficiency_Homo sapiens_hsa053401.32011248
26Systemic lupus erythematosus_Homo sapiens_hsa053221.31612942
27Pyrimidine metabolism_Homo sapiens_hsa002401.31246884
28Nucleotide excision repair_Homo sapiens_hsa034201.29798081
29Linoleic acid metabolism_Homo sapiens_hsa005911.29654958
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.23662332
31Retinol metabolism_Homo sapiens_hsa008301.22238387
32Alcoholism_Homo sapiens_hsa050341.19055059
33Purine metabolism_Homo sapiens_hsa002301.13179177
34Butanoate metabolism_Homo sapiens_hsa006501.07388099
35One carbon pool by folate_Homo sapiens_hsa006701.06948951
36Spliceosome_Homo sapiens_hsa030401.04410241
37Ovarian steroidogenesis_Homo sapiens_hsa049131.03751228
38Herpes simplex infection_Homo sapiens_hsa051680.96075510
39Fatty acid biosynthesis_Homo sapiens_hsa000610.94854847
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92942312
41p53 signaling pathway_Homo sapiens_hsa041150.87464942
42Insulin secretion_Homo sapiens_hsa049110.85348219
43Cholinergic synapse_Homo sapiens_hsa047250.81489227
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77124545
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76547553
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.76028168
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.74798064
48Serotonergic synapse_Homo sapiens_hsa047260.73958229
49Protein export_Homo sapiens_hsa030600.73615038
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70952293
51B cell receptor signaling pathway_Homo sapiens_hsa046620.68247645
52Morphine addiction_Homo sapiens_hsa050320.67790127
53Vitamin B6 metabolism_Homo sapiens_hsa007500.64814741
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62311612
55Chemical carcinogenesis_Homo sapiens_hsa052040.61486178
56Colorectal cancer_Homo sapiens_hsa052100.61248152
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.60827805
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57824654
59GABAergic synapse_Homo sapiens_hsa047270.57276119
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.56227526
61Apoptosis_Homo sapiens_hsa042100.55714588
62Huntingtons disease_Homo sapiens_hsa050160.55342875
63Arachidonic acid metabolism_Homo sapiens_hsa005900.55121653
64Hedgehog signaling pathway_Homo sapiens_hsa043400.54953415
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53671520
66Dopaminergic synapse_Homo sapiens_hsa047280.52016915
67cAMP signaling pathway_Homo sapiens_hsa040240.51710707
68Cocaine addiction_Homo sapiens_hsa050300.50862370
69Lysine degradation_Homo sapiens_hsa003100.49986965
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48798058
71Folate biosynthesis_Homo sapiens_hsa007900.47014341
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43405761
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42327187
74Taste transduction_Homo sapiens_hsa047420.42224833
75Viral carcinogenesis_Homo sapiens_hsa052030.41452112
76Calcium signaling pathway_Homo sapiens_hsa040200.40940946
77Asthma_Homo sapiens_hsa053100.34693049
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.32437203
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31726366
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29378603
81Circadian rhythm_Homo sapiens_hsa047100.28835580
82Circadian entrainment_Homo sapiens_hsa047130.28763944
83Amphetamine addiction_Homo sapiens_hsa050310.28513468
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28294925
85HTLV-I infection_Homo sapiens_hsa051660.27839303
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.26004909
87TGF-beta signaling pathway_Homo sapiens_hsa043500.25229459
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23556908
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22954083
90Nicotine addiction_Homo sapiens_hsa050330.22237073
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20525747
92Regulation of autophagy_Homo sapiens_hsa041400.19207827
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18601960
94Legionellosis_Homo sapiens_hsa051340.17956269
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16547217
96MicroRNAs in cancer_Homo sapiens_hsa052060.16502298
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16271620
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15062834
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14869902
100Epstein-Barr virus infection_Homo sapiens_hsa051690.14852526

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