ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	8.50942420
2	synaptonemal complex organization (GO:0070193)	6.78510082
3	histone lysine demethylation (GO:0070076)	6.65649316
4	synaptonemal complex assembly (GO:0007130)	6.64384329
5	regulation of exit from mitosis (GO:0007096)	6.38316437
6	regulation of RIG-I signaling pathway (GO:0039535)	6.33810536
7	histone demethylation (GO:0016577)	6.27233772
8	positive regulation of meiosis (GO:0045836)	6.09790860
9	multicellular organism reproduction (GO:0032504)	5.95417258
10	positive regulation of meiotic cell cycle (GO:0051446)	5.75589469
11	negative regulation of Ras GTPase activity (GO:0034261)	5.66051920
12	protein dealkylation (GO:0008214)	5.65952279
13	protein demethylation (GO:0006482)	5.65952279
14	gonadal mesoderm development (GO:0007506)	5.57890788
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.54073449
16	N-terminal protein amino acid acetylation (GO:0006474)	5.47951410
17	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.33457865
18	single fertilization (GO:0007338)	4.77260224
19	chromosome organization involved in meiosis (GO:0070192)	4.71971014
20	male meiosis I (GO:0007141)	4.68784346
21	regulation of acrosome reaction (GO:0060046)	4.64020082
22	response to UV-C (GO:0010225)	4.53620946
23	protein K48-linked deubiquitination (GO:0071108)	4.44693176
24	male meiosis (GO:0007140)	4.41940512
25	positive regulation of catecholamine secretion (GO:0033605)	4.39164857
26	acrosome reaction (GO:0007340)	4.32330323
27	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.20884388
28	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.20355569
29	positive regulation of histone H3-K4 methylation (GO:0051571)	4.15367026
30	regulation of female receptivity (GO:0045924)	4.13875613
31	centriole replication (GO:0007099)	4.08991022
32	regulation of histone H3-K9 methylation (GO:0051570)	4.04816376
33	regulation of DNA endoreduplication (GO:0032875)	3.91400836
34	reproduction (GO:0000003)	3.89596480
35	meiosis I (GO:0007127)	3.88176924
36	intestinal epithelial cell development (GO:0060576)	3.87144494
37	regulation of defense response to virus by host (GO:0050691)	3.81869946
38	regulation of helicase activity (GO:0051095)	3.74435406
39	positive regulation of humoral immune response (GO:0002922)	3.73179383
40	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.70265389
41	protein K6-linked ubiquitination (GO:0085020)	3.69051074
42	protein K63-linked deubiquitination (GO:0070536)	3.61667777
43	female mating behavior (GO:0060180)	3.60610264
44	fertilization (GO:0009566)	3.53831702
45	regulation of meiosis (GO:0040020)	3.48865907
46	binding of sperm to zona pellucida (GO:0007339)	3.45530378
47	meiotic cell cycle process (GO:1903046)	3.38735769
48	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.36106629
49	regulation of ruffle assembly (GO:1900027)	3.35653786
50	meiotic cell cycle (GO:0051321)	3.32678764
51	piRNA metabolic process (GO:0034587)	3.31852038
52	poly(A)+ mRNA export from nucleus (GO:0016973)	3.28807903
53	RNA localization (GO:0006403)	3.25679167
54	negative regulation of histone modification (GO:0031057)	3.16362311
55	response to lipoprotein particle (GO:0055094)	3.11036468
56	regulation of uterine smooth muscle contraction (GO:0070472)	3.09562116
57	epithelial cilium movement (GO:0003351)	3.04997527
58	regulation of female gonad development (GO:2000194)	3.03787650
59	mitotic metaphase plate congression (GO:0007080)	3.03481425
60	DNA replication-dependent nucleosome organization (GO:0034723)	3.03192586
61	DNA replication-dependent nucleosome assembly (GO:0006335)	3.03192586
62	striated muscle atrophy (GO:0014891)	2.99805060
63	pancreas development (GO:0031016)	2.97776673
64	cilium movement (GO:0003341)	2.97218345
65	regulation of mRNA processing (GO:0050684)	2.95863891
66	tryptophan catabolic process (GO:0006569)	2.94032209
67	indole-containing compound catabolic process (GO:0042436)	2.94032209
68	indolalkylamine catabolic process (GO:0046218)	2.94032209
69	aggressive behavior (GO:0002118)	2.93333394
70	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.91513819
71	centrosome duplication (GO:0051298)	2.89959360
72	calcium ion-dependent exocytosis (GO:0017156)	2.89487462
73	demethylation (GO:0070988)	2.89337370
74	negative regulation of chromatin modification (GO:1903309)	2.89309581
75	maturation of SSU-rRNA (GO:0030490)	2.88797460
76	mitochondrial RNA metabolic process (GO:0000959)	2.88645896
77	sperm-egg recognition (GO:0035036)	2.87767234
78	regulation of meiotic cell cycle (GO:0051445)	2.86978268
79	N-terminal protein amino acid modification (GO:0031365)	2.85790767
80	regulation of receptor binding (GO:1900120)	2.85149951
81	organ formation (GO:0048645)	2.85018736
82	intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)	2.84513131
83	natural killer cell differentiation (GO:0001779)	2.84269687
84	citrulline biosynthetic process (GO:0019240)	2.84104796
85	positive regulation of skeletal muscle tissue development (GO:0048643)	2.82420050
86	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.82294955
87	positive regulation of prostaglandin secretion (GO:0032308)	2.80843593
88	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.79951885
89	negative regulation of digestive system process (GO:0060457)	2.77764152
90	telomere maintenance via telomerase (GO:0007004)	2.76454378
91	fat-soluble vitamin catabolic process (GO:0042363)	2.76187568
92	vitamin catabolic process (GO:0009111)	2.76187568
93	pyrimidine dimer repair (GO:0006290)	2.75791984
94	spermatid development (GO:0007286)	2.75151962
95	kynurenine metabolic process (GO:0070189)	2.74654586
96	microtubule severing (GO:0051013)	2.74434921
97	protein kinase C signaling (GO:0070528)	2.71908509
98	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.70468459
99	regulation of centriole replication (GO:0046599)	2.70003125
100	histone H3-K9 demethylation (GO:0033169)	17.2008415

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.61985267
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.78058509
3	VDR_22108803_ChIP-Seq_LS180_Human	4.23390420
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.07165305
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.82702348
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.51016474
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.36780575
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.08231664
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.80872083
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78845252
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.59563967
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.57908143
13	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.52349291
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.37885926
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23255291
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.22738645
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07026564
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05386492
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.98881851
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.96741990
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.96220297
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89347571
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.89263118
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.86063210
25	TCF4_23295773_ChIP-Seq_U87_Human	1.77417104
26	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.77357373
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.75872992
28	CBP_21632823_ChIP-Seq_H3396_Human	1.73335192
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.70373116
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.67227288
31	RXR_22108803_ChIP-Seq_LS180_Human	1.60746631
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59277637
33	SMRT_27268052_Chip-Seq_Bcells_Human	1.49241392
34	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.48744044
35	AR_25329375_ChIP-Seq_VCAP_Human	1.48293263
36	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.48196636
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44407452
38	STAT3_23295773_ChIP-Seq_U87_Human	1.42031343
39	P300_19829295_ChIP-Seq_ESCs_Human	1.41860592
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.40426054
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38153404
42	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.37298078
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35684353
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35038449
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34585198
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33475676
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31177989
48	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.30282693
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.29327892
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27854524
51	NCOR_22424771_ChIP-Seq_293T_Human	1.26510960
52	GF1_26923725_Chip-Seq_HPCs_Mouse	1.24699398
53	AR_21909140_ChIP-Seq_LNCAP_Human	1.22835689
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.22053609
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20950710
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.19926194
57	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19660764
58	* GATA3_26560356_Chip-Seq_TH1_Human	1.19508273
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18231571
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.17661216
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16698513
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.16060715
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14904400
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14797981
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14003471
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13571669
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13501713
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12096954
69	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11872406
70	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11140813
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10840439
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10513517
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08467759
74	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.07861113
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06249229
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.05369871
77	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04319199
78	RAC3_21632823_ChIP-Seq_H3396_Human	1.02822444
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01144902
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01003964
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00673792
82	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.99442208
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99364614
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98216190
85	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.97164259
86	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.95815420
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.94328369
88	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.93765331
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92754734
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.91563830
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91563830
92	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.90674003
93	EWS_26573619_Chip-Seq_HEK293_Human	0.90008191
94	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88780838
95	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.88425062
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.88108599
97	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.87159900
98	VDR_23849224_ChIP-Seq_CD4+_Human	0.86732177
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.86724388
100	P300_27268052_Chip-Seq_Bcells_Human	0.83751145

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	5.91817224
2	MP0006292_abnormal_olfactory_placode	5.80792498
3	MP0003950_abnormal_plasma_membrane	3.91144514
4	MP0003693_abnormal_embryo_hatching	3.78108224
5	MP0009379_abnormal_foot_pigmentation	3.57726334
6	MP0000678_abnormal_parathyroid_gland	3.48514467
7	MP0002160_abnormal_reproductive_system	3.30998078
8	MP0008058_abnormal_DNA_repair	3.09985121
9	MP0010094_abnormal_chromosome_stability	2.81340067
10	MP0000427_abnormal_hair_cycle	2.72340540
11	MP0005410_abnormal_fertilization	2.49106266
12	MP0003136_yellow_coat_color	2.44574310
13	MP0001929_abnormal_gametogenesis	2.34039324
14	MP0002751_abnormal_autonomic_nervous	2.19077484
15	MP0002210_abnormal_sex_determination	2.10601505
16	MP0005220_abnormal_exocrine_pancreas	2.07127765
17	MP0000372_irregular_coat_pigmentation	1.93550910
18	MP0006276_abnormal_autonomic_nervous	1.89613386
19	MP0003077_abnormal_cell_cycle	1.85743166
20	MP0003866_abnormal_defecation	1.80940287
21	MP0009840_abnormal_foam_cell	1.77414645
22	MP0005389_reproductive_system_phenotype	1.75553985
23	MP0001666_abnormal_nutrient_absorption	1.73185900
24	MP0000685_abnormal_immune_system	1.72917745
25	MP0001664_abnormal_digestion	1.72853013
26	MP0001502_abnormal_circadian_rhythm	1.68706598
27	MP0003699_abnormal_female_reproductive	1.65480144
28	MP0006072_abnormal_retinal_apoptosis	1.61238330
29	MP0000049_abnormal_middle_ear	1.60203682
30	MP0005360_urolithiasis	1.59652692
31	MP0003119_abnormal_digestive_system	1.57608344
32	MP0005076_abnormal_cell_differentiation	1.57051736
33	MP0003868_abnormal_feces_composition	1.53683085
34	MP0004381_abnormal_hair_follicle	1.52276607
35	MP0001986_abnormal_taste_sensitivity	1.50581996
36	MP0002396_abnormal_hematopoietic_system	1.49757714
37	MP0004043_abnormal_pH_regulation	1.45664887
38	MP0000653_abnormal_sex_gland	1.42894085
39	MP0003890_abnormal_embryonic-extraembry	1.38113091
40	MP0003111_abnormal_nucleus_morphology	1.33590253
41	MP0005645_abnormal_hypothalamus_physiol	1.31793556
42	MP0005647_abnormal_sex_gland	1.31663828
43	MP0004233_abnormal_muscle_weight	1.31253452
44	MP0008877_abnormal_DNA_methylation	1.27056720
45	MP0003698_abnormal_male_reproductive	1.25872337
46	MP0001119_abnormal_female_reproductive	1.21799122
47	MP0010307_abnormal_tumor_latency	1.21726184
48	MP0001730_embryonic_growth_arrest	1.20458612
49	MP0001145_abnormal_male_reproductive	1.18475896
50	MP0005646_abnormal_pituitary_gland	1.17842035
51	MP0003183_abnormal_peptide_metabolism	1.15162904
52	MP0000631_abnormal_neuroendocrine_gland	1.14023393
53	MP0000470_abnormal_stomach_morphology	1.13383816
54	MP0005423_abnormal_somatic_nervous	1.07658443
55	MP0000350_abnormal_cell_proliferation	1.04877137
56	MP0002161_abnormal_fertility/fecundity	1.03790526
57	MP0003938_abnormal_ear_development	1.03748531
58	MP0005075_abnormal_melanosome_morpholog	0.98948452
59	MP0005310_abnormal_salivary_gland	0.96778497
60	MP0003718_maternal_effect	0.96022776
61	MP0002102_abnormal_ear_morphology	0.94993697
62	MP0003936_abnormal_reproductive_system	0.94377644
63	MP0001501_abnormal_sleep_pattern	0.91941530
64	MP0002332_abnormal_exercise_endurance	0.90081268
65	MP0002090_abnormal_vision	0.89502452
66	MP0003763_abnormal_thymus_physiology	0.89433161
67	MP0000462_abnormal_digestive_system	0.85019231
68	MP0005253_abnormal_eye_physiology	0.83317096
69	MP0001944_abnormal_pancreas_morphology	0.82680201
70	MP0001286_abnormal_eye_development	0.81640956
71	MP0002876_abnormal_thyroid_physiology	0.79168094
72	MP0002095_abnormal_skin_pigmentation	0.76905085
73	MP0002138_abnormal_hepatobiliary_system	0.76176335
74	MP0002184_abnormal_innervation	0.73691145
75	MP0002277_abnormal_respiratory_mucosa	0.73456359
76	MP0005623_abnormal_meninges_morphology	0.71504038
77	MP0008057_abnormal_DNA_replication	0.70525400
78	MP0005551_abnormal_eye_electrophysiolog	0.69938063
79	MP0000230_abnormal_systemic_arterial	0.68836932
80	MP0001293_anophthalmia	0.68110746
81	MP0003959_abnormal_lean_body	0.68083996
82	MP0003121_genomic_imprinting	0.67827742
83	MP0002693_abnormal_pancreas_physiology	0.66916564
84	MP0003786_premature_aging	0.65768927
85	MP0002229_neurodegeneration	0.63332371
86	MP0002272_abnormal_nervous_system	0.63232849
87	MP0000465_gastrointestinal_hemorrhage	0.62697915
88	MP0009765_abnormal_xenobiotic_induced	0.61875597
89	MP0004742_abnormal_vestibular_system	0.61697221
90	MP0002019_abnormal_tumor_incidence	0.60438684
91	MP0004134_abnormal_chest_morphology	0.57302785
92	MP0002249_abnormal_larynx_morphology	0.57102121
93	MP0000534_abnormal_ureter_morphology	0.56983415
94	MP0002163_abnormal_gland_morphology	0.56796909
95	MP0004957_abnormal_blastocyst_morpholog	0.56565138
96	MP0001440_abnormal_grooming_behavior	0.54495592
97	MP0000689_abnormal_spleen_morphology	0.52922941
98	MP0009384_cardiac_valve_regurgitation	0.50466928
99	MP0000428_abnormal_craniofacial_morphol	0.49494948
100	MP0003879_abnormal_hair_cell	0.47667357

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	7.09644391
2	Median cleft lip (HP:0000161)	4.51659656
3	Microglossia (HP:0000171)	4.06099011
4	Oligodactyly (hands) (HP:0001180)	3.98606386
5	Short tibia (HP:0005736)	3.97903561
6	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.93240409
7	Abnormal number of incisors (HP:0011064)	3.86281589
8	Atonic seizures (HP:0010819)	3.80488956
9	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.60562217
10	Impulsivity (HP:0100710)	3.51052020
11	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.44453889
12	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.44453889
13	Prostate neoplasm (HP:0100787)	3.34380388
14	Hyperphosphatemia (HP:0002905)	3.22030686
15	Abnormal auditory evoked potentials (HP:0006958)	3.18654134
16	Abnormality of the nasal septum (HP:0000419)	3.12361055
17	Chromsome breakage (HP:0040012)	3.11670536
18	Congenital sensorineural hearing impairment (HP:0008527)	3.08507991
19	Abnormality of chromosome stability (HP:0003220)	3.06891114
20	Short chin (HP:0000331)	3.04373654
21	Agammaglobulinemia (HP:0004432)	3.01235509
22	Adrenal hypoplasia (HP:0000835)	2.96052104
23	Tetany (HP:0001281)	2.94488733
24	Facial cleft (HP:0002006)	2.91193883
25	Abnormality of the corticospinal tract (HP:0002492)	2.82601861
26	Amelogenesis imperfecta (HP:0000705)	2.81763523
27	Reticulocytopenia (HP:0001896)	2.79035176
28	Ectopic kidney (HP:0000086)	2.67650718
29	Poikiloderma (HP:0001029)	2.62221090
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.62030390
31	Chronic sinusitis (HP:0011109)	2.61500721
32	Oligodactyly (HP:0012165)	2.60211114
33	Metaphyseal dysplasia (HP:0100255)	2.57512751
34	Abnormality of the labia minora (HP:0012880)	2.50819919
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.50493644
36	Recurrent bronchitis (HP:0002837)	2.45851280
37	Submucous cleft hard palate (HP:0000176)	2.41527207
38	Meckel diverticulum (HP:0002245)	2.41048058
39	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40259926
40	Pancreatic fibrosis (HP:0100732)	2.40060702
41	Autoimmune thrombocytopenia (HP:0001973)	2.37629128
42	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35098780
43	Abnormality of the ileum (HP:0001549)	2.34482350
44	Microretrognathia (HP:0000308)	2.32880711
45	Tetraparesis (HP:0002273)	2.30951216
46	Abnormality of lateral ventricle (HP:0030047)	2.28563324
47	Absence seizures (HP:0002121)	2.28523382
48	Abnormality of dental color (HP:0011073)	2.25559106
49	Absent thumb (HP:0009777)	2.23998066
50	Maternal diabetes (HP:0009800)	2.22148765
51	Abnormality of abdominal situs (HP:0011620)	2.17133043
52	Abdominal situs inversus (HP:0003363)	2.17133043
53	Clubbing of toes (HP:0100760)	2.16583604
54	Abnormality of the frontal sinuses (HP:0002687)	2.14174117
55	Genu varum (HP:0002970)	2.12592908
56	Autoimmune hemolytic anemia (HP:0001890)	2.11691408
57	Abnormality of the preputium (HP:0100587)	2.11433299
58	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.11070900
59	Exertional dyspnea (HP:0002875)	2.10765511
60	Mitochondrial inheritance (HP:0001427)	2.07626478
61	Increased CSF lactate (HP:0002490)	2.07616291
62	Small intestinal stenosis (HP:0012848)	2.06587218
63	Duodenal stenosis (HP:0100867)	2.06587218
64	Abnormality of the incisor (HP:0000676)	2.06306477
65	Disproportionate short-trunk short stature (HP:0003521)	2.05993544
66	Diastasis recti (HP:0001540)	2.03452821
67	Anhidrosis (HP:0000970)	2.01101358
68	Dialeptic seizures (HP:0011146)	1.98840943
69	Increased hepatocellular lipid droplets (HP:0006565)	1.97931892
70	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.95454622
71	Supernumerary spleens (HP:0009799)	1.93835273
72	Neoplasm of the adrenal cortex (HP:0100641)	1.93039059
73	Acute necrotizing encephalopathy (HP:0006965)	1.92831967
74	Abnormal ciliary motility (HP:0012262)	1.91716768
75	Loss of speech (HP:0002371)	1.91070601
76	Short thumb (HP:0009778)	1.90918353
77	Facial hemangioma (HP:0000329)	1.90462129
78	Bronchitis (HP:0012387)	1.89390671
79	Sandal gap (HP:0001852)	1.88885736
80	Type I diabetes mellitus (HP:0100651)	1.87705466
81	Glossoptosis (HP:0000162)	1.83625034
82	B lymphocytopenia (HP:0010976)	1.83095170
83	Abnormality of the epiphyses of the hand (HP:0005924)	1.82942153
84	Abnormality of DNA repair (HP:0003254)	1.81119429
85	Osteomyelitis (HP:0002754)	1.79660269
86	Partial agenesis of the corpus callosum (HP:0001338)	1.78016033
87	Abnormal pancreas size (HP:0012094)	1.77907482
88	Volvulus (HP:0002580)	1.76674502
89	Hypoplasia of the radius (HP:0002984)	1.76471145
90	Oligomenorrhea (HP:0000876)	1.73951454
91	Hypoplasia of the iris (HP:0007676)	1.73871944
92	Fair hair (HP:0002286)	1.72948827
93	Sensory axonal neuropathy (HP:0003390)	1.72520477
94	Apathy (HP:0000741)	1.71618481
95	Renal Fanconi syndrome (HP:0001994)	1.70119798
96	Rhinitis (HP:0012384)	1.68117202
97	Hypoproteinemia (HP:0003075)	1.67533741
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.66620353
99	Abnormality of B cell number (HP:0010975)	1.66429672
100	Neurofibrillary tangles (HP:0002185)	1.64672943

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.84681559
2	STK16	5.29251521
3	TLK1	4.24597216
4	CDK12	3.45940444
5	ICK	3.31511918
6	PLK4	3.00754727
7	VRK1	2.62897930
8	VRK2	2.56765184
9	TNIK	2.54021384
10	ZAK	2.49028570
11	TAOK3	2.42896948
12	CDC7	2.33066542
13	STK39	2.31488868
14	AURKA	2.27593516
15	SRPK1	2.26820919
16	CDK19	2.18938657
17	BMPR1B	1.99101403
18	GRK1	1.93327792
19	MAP3K10	1.92851015
20	NLK	1.80016474
21	BUB1	1.61667308
22	ACVR1B	1.54125882
23	NUAK1	1.51592517
24	TEC	1.35186326
25	MAPKAPK3	1.29893423
26	TTK	1.27635860
27	TRIM28	1.25500930
28	CHEK2	1.24025890
29	MAP2K3	1.18415941
30	WNK1	1.11610024
31	ARAF	1.11177835
32	AURKB	1.09777267
33	MELK	1.08831936
34	CDK8	1.01787606
35	CDK7	0.98215764
36	LATS2	0.90221254
37	WNK4	0.88676412
38	PLK1	0.86890559
39	SGK2	0.86749078
40	PLK2	0.83239596
41	OXSR1	0.81361953
42	EPHA4	0.77878396
43	TGFBR1	0.77824811
44	PBK	0.76833168
45	PIK3CG	0.73886741
46	EIF2AK3	0.72633038
47	MARK2	0.70360285
48	GRK7	0.69260605
49	RAF1	0.68941377
50	MAPK11	0.68598362
51	STK24	0.66808466
52	MAPK13	0.66353337
53	PIK3CA	0.65001119
54	MAPKAPK2	0.64802950
55	PKN1	0.64732983
56	CHEK1	0.64509164
57	CDK4	0.63044975
58	BRAF	0.60174943
59	PIM1	0.58078982
60	LIMK1	0.57727897
61	ATR	0.57400339
62	MAP3K3	0.53738786
63	PRKCI	0.52903563
64	PIM2	0.49373918
65	MARK3	0.48626305
66	CAMK4	0.44077580
67	ERN1	0.41144904
68	RPS6KA5	0.39255762
69	SGK494	0.38764439
70	SGK223	0.38764439
71	CDK2	0.38526094
72	ATM	0.38161111
73	RPS6KB2	0.36916544
74	GRK5	0.34912923
75	PRKD1	0.34503604
76	CSNK1G1	0.33221719
77	CSNK1D	0.32591304
78	PLK3	0.32580813
79	CDK1	0.31165171
80	CDK9	0.31020202
81	PRKACA	0.28222553
82	MAPK12	0.27261233
83	STK3	0.26914177
84	DAPK1	0.25679661
85	CSNK1E	0.24844972
86	RPS6KB1	0.24689384
87	SYK	0.24227142
88	PRKAA1	0.22902109
89	CAMK1D	0.22272841
90	CSNK2A1	0.19706670
91	FRK	0.19034106
92	AKT2	0.18546141
93	CSNK2A2	0.18105937
94	SGK3	0.17780035
95	IRAK4	0.17711303
96	NEK6	0.17549786
97	MAPK4	0.17386256
98	LYN	0.17012406
99	IRAK1	0.16947953
100	STK10	0.16785424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	6.30200924
2	Mismatch repair_Homo sapiens_hsa03430	3.81038716
3	Homologous recombination_Homo sapiens_hsa03440	3.25829943
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.98959104
5	Ribosome_Homo sapiens_hsa03010	2.97763066
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.69234021
7	DNA replication_Homo sapiens_hsa03030	2.67735955
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.55582900
9	Phototransduction_Homo sapiens_hsa04744	2.50447666
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.37898846
11	Basal transcription factors_Homo sapiens_hsa03022	2.36632217
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.28954981
13	RNA polymerase_Homo sapiens_hsa03020	2.01420032
14	RNA degradation_Homo sapiens_hsa03018	1.92275309
15	Sulfur metabolism_Homo sapiens_hsa00920	1.89805344
16	Bile secretion_Homo sapiens_hsa04976	1.84026654
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.73957987
18	RNA transport_Homo sapiens_hsa03013	1.69187277
19	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.67431826
20	Olfactory transduction_Homo sapiens_hsa04740	1.62677540
21	Oocyte meiosis_Homo sapiens_hsa04114	1.62161830
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.43413386
23	Base excision repair_Homo sapiens_hsa03410	1.42378359
24	Cell cycle_Homo sapiens_hsa04110	1.37142167
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.32011248
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.31612942
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31246884
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.29798081
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29654958
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23662332
31	Retinol metabolism_Homo sapiens_hsa00830	1.22238387
32	Alcoholism_Homo sapiens_hsa05034	1.19055059
33	Purine metabolism_Homo sapiens_hsa00230	1.13179177
34	Butanoate metabolism_Homo sapiens_hsa00650	1.07388099
35	One carbon pool by folate_Homo sapiens_hsa00670	1.06948951
36	Spliceosome_Homo sapiens_hsa03040	1.04410241
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.03751228
38	Herpes simplex infection_Homo sapiens_hsa05168	0.96075510
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.94854847
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.92942312
41	p53 signaling pathway_Homo sapiens_hsa04115	0.87464942
42	Insulin secretion_Homo sapiens_hsa04911	0.85348219
43	Cholinergic synapse_Homo sapiens_hsa04725	0.81489227
44	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.77124545
45	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.76547553
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76028168
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.74798064
48	Serotonergic synapse_Homo sapiens_hsa04726	0.73958229
49	Protein export_Homo sapiens_hsa03060	0.73615038
50	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.70952293
51	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.68247645
52	Morphine addiction_Homo sapiens_hsa05032	0.67790127
53	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64814741
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62311612
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61486178
56	Colorectal cancer_Homo sapiens_hsa05210	0.61248152
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60827805
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57824654
59	GABAergic synapse_Homo sapiens_hsa04727	0.57276119
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56227526
61	Apoptosis_Homo sapiens_hsa04210	0.55714588
62	Huntingtons disease_Homo sapiens_hsa05016	0.55342875
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55121653
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54953415
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53671520
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.52016915
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.51710707
68	Cocaine addiction_Homo sapiens_hsa05030	0.50862370
69	Lysine degradation_Homo sapiens_hsa00310	0.49986965
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48798058
71	Folate biosynthesis_Homo sapiens_hsa00790	0.47014341
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43405761
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42327187
74	Taste transduction_Homo sapiens_hsa04742	0.42224833
75	Viral carcinogenesis_Homo sapiens_hsa05203	0.41452112
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.40940946
77	Asthma_Homo sapiens_hsa05310	0.34693049
78	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.32437203
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.31726366
80	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.29378603
81	Circadian rhythm_Homo sapiens_hsa04710	0.28835580
82	Circadian entrainment_Homo sapiens_hsa04713	0.28763944
83	Amphetamine addiction_Homo sapiens_hsa05031	0.28513468
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28294925
85	HTLV-I infection_Homo sapiens_hsa05166	0.27839303
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26004909
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.25229459
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23556908
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22954083
90	Nicotine addiction_Homo sapiens_hsa05033	0.22237073
91	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.20525747
92	Regulation of autophagy_Homo sapiens_hsa04140	0.19207827
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.18601960
94	Legionellosis_Homo sapiens_hsa05134	0.17956269
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.16547217
96	MicroRNAs in cancer_Homo sapiens_hsa05206	0.16502298
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16271620
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.15062834
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.14869902
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.14852526

FRG2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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