ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of meiosis (GO:0045836)	6.72327907
2	oocyte development (GO:0048599)	6.33159818
3	positive regulation of meiotic cell cycle (GO:0051446)	6.32315316
4	multicellular organism reproduction (GO:0032504)	5.71168647
5	synaptonemal complex organization (GO:0070193)	5.65077744
6	negative regulation of Ras GTPase activity (GO:0034261)	5.49134106
7	histone lysine demethylation (GO:0070076)	5.37632840
8	synaptonemal complex assembly (GO:0007130)	5.35005529
9	gonadal mesoderm development (GO:0007506)	5.27292304
10	histone demethylation (GO:0016577)	5.13816437
11	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.11853970
12	regulation of acrosome reaction (GO:0060046)	4.93771852
13	regulation of RIG-I signaling pathway (GO:0039535)	4.91985809
14	regulation of exit from mitosis (GO:0007096)	4.79879131
15	protein demethylation (GO:0006482)	4.70153631
16	protein dealkylation (GO:0008214)	4.70153631
17	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.58379500
18	positive regulation of catecholamine secretion (GO:0033605)	4.56337540
19	acrosome reaction (GO:0007340)	4.49632115
20	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.39603615
21	piRNA metabolic process (GO:0034587)	4.35414156
22	single fertilization (GO:0007338)	4.29656303
23	male meiosis (GO:0007140)	4.29231298
24	epithelial cilium movement (GO:0003351)	4.25589757
25	regulation of female receptivity (GO:0045924)	3.98839407
26	male meiosis I (GO:0007141)	3.97917799
27	cilium movement (GO:0003341)	3.87773193
28	protein K48-linked deubiquitination (GO:0071108)	3.81543092
29	centriole replication (GO:0007099)	3.78628374
30	N-terminal protein amino acid acetylation (GO:0006474)	3.75411583
31	indole-containing compound catabolic process (GO:0042436)	3.75317973
32	indolalkylamine catabolic process (GO:0046218)	3.75317973
33	tryptophan catabolic process (GO:0006569)	3.75317973
34	indolalkylamine metabolic process (GO:0006586)	3.73567778
35	chromosome organization involved in meiosis (GO:0070192)	3.65340198
36	kynurenine metabolic process (GO:0070189)	3.62279766
37	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.60950422
38	reproduction (GO:0000003)	3.57758531
39	aggressive behavior (GO:0002118)	3.48092332
40	regulation of meiosis (GO:0040020)	3.46020581
41	regulation of uterine smooth muscle contraction (GO:0070472)	3.43064628
42	behavioral response to nicotine (GO:0035095)	3.42750359
43	female mating behavior (GO:0060180)	3.32640213
44	peristalsis (GO:0030432)	3.28135324
45	regulation of defense response to virus by host (GO:0050691)	3.26621602
46	tryptophan metabolic process (GO:0006568)	3.21571164
47	fertilization (GO:0009566)	3.20142195
48	DNA methylation involved in gamete generation (GO:0043046)	3.14075297
49	protein K63-linked deubiquitination (GO:0070536)	3.13954163
50	calcium ion-dependent exocytosis (GO:0017156)	3.12603692
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10585251
52	positive regulation of histone H3-K4 methylation (GO:0051571)	3.09052483
53	meiosis I (GO:0007127)	3.07950090
54	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.04746089
55	regulation of penile erection (GO:0060405)	3.01055491
56	regulation of ruffle assembly (GO:1900027)	2.98848351
57	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.98557875
58	meiotic cell cycle (GO:0051321)	2.96600269
59	binding of sperm to zona pellucida (GO:0007339)	2.94130280
60	positive regulation of digestive system process (GO:0060456)	2.92183709
61	cochlea development (GO:0090102)	2.91428147
62	regulation of helicase activity (GO:0051095)	2.91374843
63	postsynaptic membrane organization (GO:0001941)	2.88455970
64	demethylation (GO:0070988)	2.87717354
65	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.87456617
66	neurofilament cytoskeleton organization (GO:0060052)	2.86603177
67	spermatid development (GO:0007286)	2.85910639
68	indole-containing compound metabolic process (GO:0042430)	2.82919071
69	NAD biosynthetic process (GO:0009435)	2.82050760
70	regulation of meiotic cell cycle (GO:0051445)	2.81945943
71	regulation of neurotransmitter uptake (GO:0051580)	2.80930803
72	sperm-egg recognition (GO:0035036)	2.80018174
73	phasic smooth muscle contraction (GO:0014821)	2.79797894
74	exocrine pancreas development (GO:0031017)	2.76465283
75	regulation of DNA endoreduplication (GO:0032875)	2.76059402
76	maternal behavior (GO:0042711)	2.75447166
77	positive regulation of prostaglandin secretion (GO:0032308)	2.74033445
78	protein K6-linked ubiquitination (GO:0085020)	2.73046737
79	ventricular system development (GO:0021591)	2.72054156
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71488202
81	negative regulation of digestive system process (GO:0060457)	2.70271425
82	sleep (GO:0030431)	2.69900741
83	pancreas development (GO:0031016)	2.69864723
84	cellular anion homeostasis (GO:0030002)	2.69782617
85	fat-soluble vitamin catabolic process (GO:0042363)	2.68920111
86	vitamin catabolic process (GO:0009111)	2.68920111
87	positive regulation of amine transport (GO:0051954)	2.68031906
88	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.67672580
89	negative regulation of reproductive process (GO:2000242)	2.66691167
90	protein complex biogenesis (GO:0070271)	2.66225029
91	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65776605
92	NADH dehydrogenase complex assembly (GO:0010257)	2.65776605
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65776605
94	photoreceptor cell maintenance (GO:0045494)	2.65647941
95	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.63873053
96	meiotic cell cycle process (GO:1903046)	2.62900227
97	hindbrain development (GO:0030902)	2.61392398
98	response to UV-C (GO:0010225)	2.60605446
99	RNA localization (GO:0006403)	2.60205540
100	histone H3-K9 demethylation (GO:0033169)	14.5270994

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.17731565
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.54647731
3	VDR_22108803_ChIP-Seq_LS180_Human	3.47397421
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.45852065
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.15374586
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76183891
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70061079
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.59667634
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.57013671
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53915907
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52831207
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.23881233
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13836220
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.13316728
15	P300_19829295_ChIP-Seq_ESCs_Human	2.08074976
16	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.99410047
17	RNF2_27304074_Chip-Seq_NSC_Mouse	1.95589337
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.93446143
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85805947
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.84808306
21	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.82597881
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79665259
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.79209339
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78633777
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74425300
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74254203
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70971870
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.70581864
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67760631
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.67144353
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66410743
32	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.64799475
33	* TCF4_23295773_ChIP-Seq_U87_Human	1.64256464
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64231803
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63389089
36	AR_25329375_ChIP-Seq_VCAP_Human	1.63172363
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62665134
38	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.62339057
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58456595
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56548756
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55453407
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55283967
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.54949490
44	* STAT3_23295773_ChIP-Seq_U87_Human	1.53820686
45	FUS_26573619_Chip-Seq_HEK293_Human	1.52669168
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52502507
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51444459
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49981107
49	EWS_26573619_Chip-Seq_HEK293_Human	1.44290009
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42635428
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.42339552
52	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41747166
53	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.38807433
54	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.38238286
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.37363954
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36691803
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35945048
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35882638
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.35851508
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35095208
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31915219
62	CBP_21632823_ChIP-Seq_H3396_Human	1.30536553
63	* TCF4_22108803_ChIP-Seq_LS180_Human	1.28760070
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.27687824
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22008394
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21487532
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.20112684
68	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19963958
69	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.19132170
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18643865
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.18643865
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17103314
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16429673
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15450524
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14426854
76	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.13633187
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12632519
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12530475
79	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12000889
80	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.11627847
81	ER_23166858_ChIP-Seq_MCF-7_Human	1.10295892
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06792693
83	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.05443306
84	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.05443306
85	* NCOR_22424771_ChIP-Seq_293T_Human	1.05309415
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04842739
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04579445
88	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.03438450
89	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.02663325
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01539369
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00796326
92	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00162574
93	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00162574
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.98636952
95	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98496100
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96135142
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95928944
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95885498
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92601732
100	* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91750824

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.44441363
2	MP0003283_abnormal_digestive_organ	3.63304053
3	MP0003136_yellow_coat_color	3.27855663
4	MP0000427_abnormal_hair_cycle	2.88393038
5	MP0002160_abnormal_reproductive_system	2.86944222
6	MP0006276_abnormal_autonomic_nervous	2.73696379
7	MP0009379_abnormal_foot_pigmentation	2.55302856
8	MP0003950_abnormal_plasma_membrane	2.55062877
9	MP0005410_abnormal_fertilization	2.40171471
10	MP0000678_abnormal_parathyroid_gland	2.24410309
11	MP0008058_abnormal_DNA_repair	2.16784230
12	MP0002102_abnormal_ear_morphology	2.11738569
13	MP0001502_abnormal_circadian_rhythm	2.09185205
14	MP0005646_abnormal_pituitary_gland	2.07732705
15	MP0003693_abnormal_embryo_hatching	2.07018665
16	MP0000569_abnormal_digit_pigmentation	2.06815258
17	MP0008877_abnormal_DNA_methylation	2.02364983
18	MP0001929_abnormal_gametogenesis	1.95023378
19	MP0003119_abnormal_digestive_system	1.91593645
20	MP0004043_abnormal_pH_regulation	1.87758101
21	MP0006072_abnormal_retinal_apoptosis	1.87324389
22	MP0005220_abnormal_exocrine_pancreas	1.84181405
23	MP0002751_abnormal_autonomic_nervous	1.84083479
24	MP0001664_abnormal_digestion	1.83342932
25	MP0002163_abnormal_gland_morphology	1.80207990
26	MP0002210_abnormal_sex_determination	1.65097847
27	MP0005389_reproductive_system_phenotype	1.58181934
28	MP0000631_abnormal_neuroendocrine_gland	1.57890329
29	MP0000049_abnormal_middle_ear	1.49642252
30	MP0002272_abnormal_nervous_system	1.49285753
31	MP0009745_abnormal_behavioral_response	1.48222591
32	MP0005551_abnormal_eye_electrophysiolog	1.47457224
33	MP0003183_abnormal_peptide_metabolism	1.41776450
34	MP0003718_maternal_effect	1.38282356
35	MP0003698_abnormal_male_reproductive	1.38065171
36	MP0000778_abnormal_nervous_system	1.36836346
37	MP0003890_abnormal_embryonic-extraembry	1.35631089
38	MP0001486_abnormal_startle_reflex	1.34207755
39	MP0000653_abnormal_sex_gland	1.31038995
40	MP0004742_abnormal_vestibular_system	1.30176432
41	MP0001968_abnormal_touch/_nociception	1.29356543
42	MP0009046_muscle_twitch	1.28934244
43	MP0002277_abnormal_respiratory_mucosa	1.27615284
44	MP0003699_abnormal_female_reproductive	1.26512294
45	MP0002184_abnormal_innervation	1.23352419
46	MP0000230_abnormal_systemic_arterial	1.22188504
47	MP0002837_dystrophic_cardiac_calcinosis	1.21781855
48	MP0001666_abnormal_nutrient_absorption	1.21076709
49	MP0002735_abnormal_chemical_nociception	1.19399513
50	MP0005360_urolithiasis	1.18767213
51	MP0005499_abnormal_olfactory_system	1.16418645
52	MP0005394_taste/olfaction_phenotype	1.16418645
53	MP0001501_abnormal_sleep_pattern	1.16157600
54	MP0004142_abnormal_muscle_tone	1.15325817
55	MP0000372_irregular_coat_pigmentation	1.14077233
56	MP0005084_abnormal_gallbladder_morpholo	1.12548427
57	MP0005253_abnormal_eye_physiology	1.12479261
58	MP0001485_abnormal_pinna_reflex	1.12051393
59	MP0001145_abnormal_male_reproductive	1.09561280
60	MP0001440_abnormal_grooming_behavior	1.06155006
61	MP0003868_abnormal_feces_composition	1.04158854
62	MP0000647_abnormal_sebaceous_gland	1.03340557
63	MP0001119_abnormal_female_reproductive	1.03304820
64	MP0008872_abnormal_physiological_respon	1.02323116
65	MP0002161_abnormal_fertility/fecundity	0.99736960
66	MP0005645_abnormal_hypothalamus_physiol	0.99018674
67	MP0002736_abnormal_nociception_after	0.98934878
68	MP0002557_abnormal_social/conspecific_i	0.98490938
69	MP0002229_neurodegeneration	0.98407131
70	MP0003866_abnormal_defecation	0.98280766
71	MP0002067_abnormal_sensory_capabilities	0.95980595
72	MP0009384_cardiac_valve_regurgitation	0.94341071
73	MP0002734_abnormal_mechanical_nocicepti	0.94156089
74	MP0003936_abnormal_reproductive_system	0.93977053
75	MP0003121_genomic_imprinting	0.93717424
76	MP0003880_abnormal_central_pattern	0.92974365
77	MP0001286_abnormal_eye_development	0.91490748
78	MP0003195_calcinosis	0.91459766
79	MP0001963_abnormal_hearing_physiology	0.89355309
80	MP0003635_abnormal_synaptic_transmissio	0.88301043
81	MP0005647_abnormal_sex_gland	0.88212669
82	MP0000470_abnormal_stomach_morphology	0.87629949
83	MP0005379_endocrine/exocrine_gland_phen	0.86256211
84	MP0004270_analgesia	0.85868070
85	MP0000026_abnormal_inner_ear	0.84701733
86	MP0003938_abnormal_ear_development	0.83337692
87	MP0002752_abnormal_somatic_nervous	0.81343678
88	MP0010094_abnormal_chromosome_stability	0.80963169
89	MP0002064_seizures	0.79930558
90	MP0002693_abnormal_pancreas_physiology	0.79074676
91	MP0008789_abnormal_olfactory_epithelium	0.78890972
92	MP0005670_abnormal_white_adipose	0.78507105
93	MP0001944_abnormal_pancreas_morphology	0.77446463
94	MP0002090_abnormal_vision	0.76967892
95	MP0003937_abnormal_limbs/digits/tail_de	0.75586260
96	MP0002095_abnormal_skin_pigmentation	0.72789758
97	MP0001764_abnormal_homeostasis	0.72363927
98	MP0002572_abnormal_emotion/affect_behav	0.71855446
99	MP0009840_abnormal_foam_cell	0.71446834
100	MP0005195_abnormal_posterior_eye	0.71264443

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	4.51571449
2	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.14621029
3	Short tibia (HP:0005736)	4.10568464
4	Median cleft lip (HP:0000161)	4.07781410
5	Oligodactyly (hands) (HP:0001180)	3.95347927
6	Pancreatic fibrosis (HP:0100732)	3.90284729
7	Atonic seizures (HP:0010819)	3.81425656
8	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.37685263
9	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.37685263
10	Amelogenesis imperfecta (HP:0000705)	3.21538315
11	Abnormal ciliary motility (HP:0012262)	2.94139600
12	Congenital sensorineural hearing impairment (HP:0008527)	2.93912179
13	Abnormality of the nasal septum (HP:0000419)	2.93282480
14	Medial flaring of the eyebrow (HP:0010747)	2.90096752
15	Adrenal hypoplasia (HP:0000835)	2.89441116
16	Tetany (HP:0001281)	2.80107504
17	Absent/shortened dynein arms (HP:0200106)	2.76405561
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.76405561
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.76011408
20	Genital tract atresia (HP:0001827)	2.73530654
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.72690479
22	True hermaphroditism (HP:0010459)	2.71729669
23	Oligodactyly (HP:0012165)	2.70750163
24	Abnormality of the corticospinal tract (HP:0002492)	2.67440345
25	Impulsivity (HP:0100710)	2.66336031
26	Gait imbalance (HP:0002141)	2.61812504
27	Abnormality of the renal cortex (HP:0011035)	2.60407410
28	Hyperalaninemia (HP:0003348)	2.59701999
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59701999
30	Abnormality of alanine metabolism (HP:0010916)	2.59701999
31	Abnormality of the labia minora (HP:0012880)	2.59222583
32	Molar tooth sign on MRI (HP:0002419)	2.58450492
33	Abnormality of midbrain morphology (HP:0002418)	2.58450492
34	Microglossia (HP:0000171)	2.51519297
35	Congenital primary aphakia (HP:0007707)	2.50216653
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.49232420
37	Increased hepatocellular lipid droplets (HP:0006565)	2.49030125
38	Hyperphosphatemia (HP:0002905)	2.48011303
39	Metaphyseal dysplasia (HP:0100255)	2.47276809
40	Concave nail (HP:0001598)	2.43316757
41	Pancreatic cysts (HP:0001737)	2.42678109
42	Gaze-evoked nystagmus (HP:0000640)	2.41070360
43	Focal motor seizures (HP:0011153)	2.40044037
44	Abnormality of dental color (HP:0011073)	2.39799307
45	Abnormal number of incisors (HP:0011064)	2.39119842
46	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.37324810
47	Ectopic kidney (HP:0000086)	2.31978544
48	Abnormality of abdominal situs (HP:0011620)	2.28046896
49	Abdominal situs inversus (HP:0003363)	2.28046896
50	Abnormal auditory evoked potentials (HP:0006958)	2.23004922
51	Exertional dyspnea (HP:0002875)	2.22022945
52	Nephrogenic diabetes insipidus (HP:0009806)	2.21664899
53	Febrile seizures (HP:0002373)	2.21424875
54	Ulnar claw (HP:0001178)	2.21236343
55	Lipid accumulation in hepatocytes (HP:0006561)	2.19580224
56	Renal cortical cysts (HP:0000803)	2.15955204
57	Dialeptic seizures (HP:0011146)	2.13965129
58	Type I diabetes mellitus (HP:0100651)	2.13251501
59	Renal Fanconi syndrome (HP:0001994)	2.12379473
60	Facial cleft (HP:0002006)	2.12120837
61	Microretrognathia (HP:0000308)	2.11756948
62	Optic nerve hypoplasia (HP:0000609)	2.11472524
63	Mitochondrial inheritance (HP:0001427)	2.07320888
64	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07070966
65	Abnormal respiratory epithelium morphology (HP:0012253)	2.07070966
66	Vaginal atresia (HP:0000148)	2.06518466
67	Postaxial foot polydactyly (HP:0001830)	2.06495674
68	3-Methylglutaconic aciduria (HP:0003535)	2.05600811
69	Maternal diabetes (HP:0009800)	2.02453590
70	Increased CSF lactate (HP:0002490)	2.01552775
71	Mesangial abnormality (HP:0001966)	2.00255208
72	Abnormality of renal resorption (HP:0011038)	1.99381239
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96417566
74	Gastrointestinal atresia (HP:0002589)	1.95954830
75	Abolished electroretinogram (ERG) (HP:0000550)	1.95918224
76	Poor coordination (HP:0002370)	1.94808906
77	Myokymia (HP:0002411)	1.93537270
78	Pendular nystagmus (HP:0012043)	1.93154540
79	Disproportionate short-trunk short stature (HP:0003521)	1.92881335
80	Fair hair (HP:0002286)	1.92855586
81	Abnormality of the renal medulla (HP:0100957)	1.92796016
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.92615292
83	Nephronophthisis (HP:0000090)	1.91765069
84	Rhinitis (HP:0012384)	1.91361160
85	Preaxial hand polydactyly (HP:0001177)	1.90804066
86	Absence seizures (HP:0002121)	1.88201246
87	Attenuation of retinal blood vessels (HP:0007843)	1.85034693
88	Acute necrotizing encephalopathy (HP:0006965)	1.84013145
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83415521
90	Abnormality of chromosome stability (HP:0003220)	1.82811747
91	Short chin (HP:0000331)	1.82746109
92	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.81913731
93	Colon cancer (HP:0003003)	1.81439255
94	Retinitis pigmentosa (HP:0000510)	1.80649046
95	Submucous cleft hard palate (HP:0000176)	1.78203884
96	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78107654
97	Absent thumb (HP:0009777)	1.71581318
98	Anterior segment dysgenesis (HP:0007700)	1.68311448
99	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.67817699
100	Sclerocornea (HP:0000647)	1.67182555

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.98889477
2	TNIK	3.82849693
3	ZAK	3.74938067
4	TLK1	3.15590195
5	INSRR	3.11436973
6	VRK1	2.75219838
7	TAOK3	2.55227500
8	MAP4K2	2.53273307
9	PLK4	2.37807132
10	BMPR1B	2.34853862
11	NUAK1	2.14513882
12	STK39	2.06843548
13	FRK	2.03950638
14	AURKA	1.96391425
15	ACVR1B	1.95274625
16	SRPK1	1.77593076
17	WNK4	1.77331919
18	CDK12	1.72689904
19	CDK19	1.70414600
20	TEC	1.70253267
21	WNK3	1.61610815
22	NLK	1.56597250
23	CDC7	1.40214025
24	MARK1	1.40020929
25	ADRBK2	1.35783608
26	GRK1	1.33874616
27	CASK	1.32128810
28	MAPK13	1.31441006
29	VRK2	1.26231359
30	EPHA4	1.25214846
31	PINK1	1.19597234
32	OXSR1	1.17720565
33	PIK3CA	1.16783443
34	CHEK2	1.10135254
35	PKN1	1.05917954
36	SGK2	1.05608750
37	CSNK1G1	1.00703007
38	LATS1	0.95726806
39	WNK1	0.95018413
40	PLK2	0.90832424
41	GRK7	0.89957676
42	TTK	0.85864449
43	CAMKK2	0.81953703
44	TESK2	0.80267746
45	PLK1	0.78825941
46	RPS6KA5	0.75712811
47	TNK2	0.74798403
48	MAP2K7	0.72782045
49	TRIM28	0.72437406
50	AURKB	0.71648661
51	MELK	0.67016436
52	TGFBR1	0.65299185
53	NTRK2	0.64902170
54	PBK	0.61831068
55	CSNK1G2	0.61596741
56	CSNK1D	0.57197236
57	PLK3	0.56435150
58	MARK2	0.56187615
59	LATS2	0.55330979
60	CAMK4	0.55090866
61	PRKCE	0.54697299
62	STK38L	0.54658442
63	CDK3	0.54584186
64	CAMK2A	0.53516960
65	DYRK3	0.53063725
66	CAMK1	0.52937142
67	PRKACA	0.52875305
68	SGK223	0.50264480
69	SGK494	0.50264480
70	CSNK1E	0.48488708
71	NME1	0.48346231
72	ADRBK1	0.45686603
73	MAP2K6	0.42987713
74	ATM	0.42358838
75	MAP2K3	0.41903409
76	ITK	0.40915252
77	PNCK	0.40598659
78	GRK5	0.39370773
79	ICK	0.38682492
80	MAPK15	0.38650346
81	STK3	0.38620769
82	DYRK2	0.38070657
83	PIM1	0.37884628
84	PRKCG	0.37811734
85	MINK1	0.36323710
86	MAP3K3	0.36222511
87	MAP3K4	0.36199711
88	DYRK1A	0.34308067
89	CSNK1G3	0.34279918
90	PRKCQ	0.32468737
91	CDK5	0.32367136
92	CHEK1	0.31980559
93	PIM2	0.31419471
94	PRKCZ	0.29101619
95	PRKG1	0.28812679
96	IRAK1	0.28752670
97	CSNK1A1	0.28713035
98	PIK3CG	0.27502028
99	PRKCA	0.26565882
100	PRKACB	0.25398809

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.82538807
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.80156471
3	Basal transcription factors_Homo sapiens_hsa03022	2.73875645
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.72281462
5	Phototransduction_Homo sapiens_hsa04744	2.65699321
6	Homologous recombination_Homo sapiens_hsa03440	2.33290401
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.14261513
8	Nicotine addiction_Homo sapiens_hsa05033	1.99536504
9	Ribosome_Homo sapiens_hsa03010	1.98430236
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98229448
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96423203
12	Mismatch repair_Homo sapiens_hsa03430	1.90389820
13	Butanoate metabolism_Homo sapiens_hsa00650	1.75720678
14	RNA polymerase_Homo sapiens_hsa03020	1.65748762
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.62918211
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59520394
17	Olfactory transduction_Homo sapiens_hsa04740	1.59380649
18	Bile secretion_Homo sapiens_hsa04976	1.56354864
19	Sulfur metabolism_Homo sapiens_hsa00920	1.50622854
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44157558
21	Insulin secretion_Homo sapiens_hsa04911	1.42351238
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.41549534
23	RNA degradation_Homo sapiens_hsa03018	1.40030564
24	Retinol metabolism_Homo sapiens_hsa00830	1.35466879
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.35420413
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34648767
27	Morphine addiction_Homo sapiens_hsa05032	1.33269898
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32045417
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31390052
30	Huntingtons disease_Homo sapiens_hsa05016	1.31070837
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.28946837
32	GABAergic synapse_Homo sapiens_hsa04727	1.27670302
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.23289749
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15929396
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14430910
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14247520
37	Serotonergic synapse_Homo sapiens_hsa04726	1.14039671
38	Parkinsons disease_Homo sapiens_hsa05012	1.13414475
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.12110595
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10351634
41	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04890954
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04879844
43	Circadian entrainment_Homo sapiens_hsa04713	1.04405383
44	Circadian rhythm_Homo sapiens_hsa04710	1.02021740
45	Protein export_Homo sapiens_hsa03060	0.98662805
46	RNA transport_Homo sapiens_hsa03013	0.96072071
47	Taste transduction_Homo sapiens_hsa04742	0.94986330
48	Salivary secretion_Homo sapiens_hsa04970	0.91338223
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91330329
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.90749456
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88902179
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.87272719
53	Cocaine addiction_Homo sapiens_hsa05030	0.87221144
54	Cholinergic synapse_Homo sapiens_hsa04725	0.85859391
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.83885759
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83014645
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.82921820
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82889935
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81455077
60	Purine metabolism_Homo sapiens_hsa00230	0.79195283
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.79157997
62	Alcoholism_Homo sapiens_hsa05034	0.78208871
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.78107705
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.77874158
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75183067
66	Oocyte meiosis_Homo sapiens_hsa04114	0.74931963
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.73273127
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72830552
69	Caffeine metabolism_Homo sapiens_hsa00232	0.71042949
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.67976966
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66616372
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66375350
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64019407
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.60964565
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.60328086
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58841597
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.57961075
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55014360
79	Amphetamine addiction_Homo sapiens_hsa05031	0.54747418
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.53091018
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52499108
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51992676
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50853344
84	Lysine degradation_Homo sapiens_hsa00310	0.49703678
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49161915
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46082052
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45229316
88	ABC transporters_Homo sapiens_hsa02010	0.42782784
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.41036042
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.40970606
91	Alzheimers disease_Homo sapiens_hsa05010	0.40038975
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38618272
93	Regulation of autophagy_Homo sapiens_hsa04140	0.37767827
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37480287
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35892205
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.34802909
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33769946
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33547397
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31696436
100	Metabolic pathways_Homo sapiens_hsa01100	0.31335660

FRG2C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »