FRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)6.83059118
2Golgi transport vesicle coating (GO:0048200)6.47960810
3COPI coating of Golgi vesicle (GO:0048205)6.47960810
4intestinal cholesterol absorption (GO:0030299)6.44323762
5UDP-N-acetylglucosamine metabolic process (GO:0006047)5.41635348
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.99085442
7bundle of His cell to Purkinje myocyte communication (GO:0086069)4.94589863
8indole-containing compound catabolic process (GO:0042436)4.85657359
9indolalkylamine catabolic process (GO:0046218)4.85657359
10tryptophan catabolic process (GO:0006569)4.85657359
11angiotensin maturation (GO:0002003)4.81144657
12COPII vesicle coating (GO:0048208)4.74566300
13regulation of pigment cell differentiation (GO:0050932)4.73883487
14intestinal epithelial cell development (GO:0060576)4.69093331
15positive regulation of developmental pigmentation (GO:0048087)4.62000480
16kynurenine metabolic process (GO:0070189)4.52978013
17protein retention in ER lumen (GO:0006621)4.49401501
18indolalkylamine metabolic process (GO:0006586)4.38812479
19negative regulation of keratinocyte proliferation (GO:0010839)4.33539842
20monoubiquitinated protein deubiquitination (GO:0035520)4.27769784
21establishment of protein localization to Golgi (GO:0072600)4.21584057
22interkinetic nuclear migration (GO:0022027)4.17771597
23tryptophan metabolic process (GO:0006568)4.09657358
24regulation of establishment of cell polarity (GO:2000114)4.07724164
25cilium or flagellum-dependent cell motility (GO:0001539)4.03925034
26protein K48-linked deubiquitination (GO:0071108)3.98839997
27peptide catabolic process (GO:0043171)3.96710028
28regulation of hippo signaling (GO:0035330)3.95465638
29snRNA transcription (GO:0009301)3.93961584
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.90834502
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.90834502
32phospholipid translocation (GO:0045332)3.79833265
33lipid translocation (GO:0034204)3.79833265
34neural tube formation (GO:0001841)3.79220450
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.72129514
36regulation of translation, ncRNA-mediated (GO:0045974)3.72129514
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.72129514
38protein K11-linked deubiquitination (GO:0035871)3.70817494
39nucleotide-sugar biosynthetic process (GO:0009226)3.70091788
40hemidesmosome assembly (GO:0031581)3.69381628
41negative regulation of sodium ion transport (GO:0010766)3.67352081
42peptide hormone processing (GO:0016486)3.65668983
43desmosome organization (GO:0002934)3.63164160
44regulation of establishment or maintenance of cell polarity (GO:0032878)3.61913602
45cellular response to vitamin D (GO:0071305)3.58406592
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57967445
47maintenance of gastrointestinal epithelium (GO:0030277)3.57850056
48oxidative demethylation (GO:0070989)3.57670713
49endocrine pancreas development (GO:0031018)3.54959912
50digestive system process (GO:0022600)3.49218740
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46087851
52regulation of gene silencing by RNA (GO:0060966)3.41192507
53regulation of posttranscriptional gene silencing (GO:0060147)3.41192507
54regulation of gene silencing by miRNA (GO:0060964)3.41192507
55signal peptide processing (GO:0006465)3.40212504
56negative regulation of protein localization to cell surface (GO:2000009)3.39129118
57bile acid and bile salt transport (GO:0015721)3.38657769
58transcytosis (GO:0045056)3.38475774
59indole-containing compound metabolic process (GO:0042430)3.36234310
60detection of light stimulus involved in sensory perception (GO:0050962)3.31511576
61detection of light stimulus involved in visual perception (GO:0050908)3.31511576
62glandular epithelial cell differentiation (GO:0002067)3.30001517
63cellular response to ethanol (GO:0071361)3.29433953
64regulation of sarcomere organization (GO:0060297)3.28651446
65hormone catabolic process (GO:0042447)3.27979818
66vitamin A metabolic process (GO:0006776)3.27915620
67adhesion of symbiont to host cell (GO:0044650)3.26873879
68virion attachment to host cell (GO:0019062)3.26873879
69negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26152815
70digestion (GO:0007586)3.25517731
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.25151349
72behavioral response to nicotine (GO:0035095)3.23157242
73protein K63-linked deubiquitination (GO:0070536)3.22127711
74nucleotide-sugar metabolic process (GO:0009225)3.20728598
75photoreceptor cell maintenance (GO:0045494)3.18197101
76reflex (GO:0060004)3.18067041
77serotonin metabolic process (GO:0042428)3.17483101
78cytoplasmic mRNA processing body assembly (GO:0033962)3.14387869
79actin filament depolymerization (GO:0030042)3.14275689
80negative regulation of systemic arterial blood pressure (GO:0003085)3.12326125
81vesicle coating (GO:0006901)3.10193008
82tight junction assembly (GO:0070830)3.05557593
83regulation of bile acid biosynthetic process (GO:0070857)3.03647328
84protein targeting to vacuole (GO:0006623)3.01588400
85protein targeting to lysosome (GO:0006622)3.01588400
86establishment of protein localization to vacuole (GO:0072666)3.01588400
87fucose catabolic process (GO:0019317)3.00767187
88L-fucose metabolic process (GO:0042354)3.00767187
89L-fucose catabolic process (GO:0042355)3.00767187
90cellular ketone body metabolic process (GO:0046950)3.00018161
91O-glycan processing (GO:0016266)2.98868203
92response to hepatocyte growth factor (GO:0035728)2.98773130
93cellular response to hepatocyte growth factor stimulus (GO:0035729)2.98773130
94NAD biosynthetic process (GO:0009435)2.97887473
95flavonoid metabolic process (GO:0009812)2.97197514
96exocrine pancreas development (GO:0031017)2.97063990
97cellular response to vitamin (GO:0071295)2.96651348
98primary amino compound metabolic process (GO:1901160)2.96599689
99endosome to melanosome transport (GO:0035646)2.94821737
100endosome to pigment granule transport (GO:0043485)2.94821737
101cellular response to sterol (GO:0036315)2.92692948
102columnar/cuboidal epithelial cell development (GO:0002066)2.92256928
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91512605
104cellular glucuronidation (GO:0052695)2.86727318
105activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84944281
106lipoprotein metabolic process (GO:0042157)2.84307725
107gamma-aminobutyric acid transport (GO:0015812)2.84286711
108pericardium development (GO:0060039)2.83553494
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83502129
110calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82755492
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82148299
112sequestering of metal ion (GO:0051238)2.77660525
113regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.77436934
114benzene-containing compound metabolic process (GO:0042537)2.76534950
115hepatocyte apoptotic process (GO:0097284)2.76223658
116amine catabolic process (GO:0009310)2.75348290
117cellular biogenic amine catabolic process (GO:0042402)2.75348290
118synaptic vesicle docking involved in exocytosis (GO:0016081)2.74964935
119regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.74575098
120drug catabolic process (GO:0042737)2.73982633
121positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.72538774
122behavioral response to ethanol (GO:0048149)2.70824525
123regulation of keratinocyte proliferation (GO:0010837)2.69723138
124tachykinin receptor signaling pathway (GO:0007217)2.69700080
125protein targeting to Golgi (GO:0000042)2.69475102
126thyroid hormone metabolic process (GO:0042403)2.68211686
127chondrocyte proliferation (GO:0035988)2.67464859
128adhesion of symbiont to host (GO:0044406)2.66843375
129histone H3-K4 trimethylation (GO:0080182)2.65620131
130glucuronate metabolic process (GO:0019585)2.65617050
131uronic acid metabolic process (GO:0006063)2.65617050
132renal absorption (GO:0070293)2.65566180
133positive regulation of nuclease activity (GO:0032075)2.65448420
134epithelial structure maintenance (GO:0010669)2.65231775
135membrane depolarization during action potential (GO:0086010)2.65214999
136ketone body metabolic process (GO:1902224)2.64921394
137central nervous system neuron axonogenesis (GO:0021955)2.64445125
138lung secretory cell differentiation (GO:0061140)2.64121034
139positive regulation of glycoprotein metabolic process (GO:1903020)2.63096679
140cardiovascular system development (GO:0072358)2.63038616
141limb development (GO:0060173)2.62638287
142appendage development (GO:0048736)2.62638287
143aromatic amino acid family catabolic process (GO:0009074)2.62452336
144protein N-linked glycosylation via asparagine (GO:0018279)2.61006740
145retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60452188
146regulation of Golgi to plasma membrane protein transport (GO:0042996)2.60152988
147endoplasmic reticulum unfolded protein response (GO:0030968)2.59932824
1484-hydroxyproline metabolic process (GO:0019471)2.58999640
149peptidyl-asparagine modification (GO:0018196)2.58468772
150sulfate transmembrane transport (GO:1902358)2.57915387
151neuronal action potential (GO:0019228)2.57748395
152fucose metabolic process (GO:0006004)2.55808987
153negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.55522620
154nucleus localization (GO:0051647)2.55504268
155positive regulation of protein localization to plasma membrane (GO:1903078)2.55136053
156regulation of apoptotic process involved in morphogenesis (GO:1902337)2.55027285
157sulfation (GO:0051923)2.53761652
158cellular response to unfolded protein (GO:0034620)2.53395192
159negative regulation of digestive system process (GO:0060457)2.53326588
160regulation of cholesterol homeostasis (GO:2000188)2.53075759
161sulfur amino acid catabolic process (GO:0000098)2.52175000
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.51564808
163diol metabolic process (GO:0034311)2.51022486
164striated muscle atrophy (GO:0014891)2.50950423
165regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50880611
166response to nitrosative stress (GO:0051409)2.50342677
167positive regulation of p38MAPK cascade (GO:1900745)2.47992309
168drug transmembrane transport (GO:0006855)2.47203804
169cell adhesion mediated by integrin (GO:0033627)2.46769231
170cilium movement (GO:0003341)2.45746320
171protein autoprocessing (GO:0016540)2.45333244
172zinc ion transport (GO:0006829)2.45130601
173negative regulation of mast cell activation (GO:0033004)2.44804076
174positive regulation of epidermal cell differentiation (GO:0045606)2.44611805
175positive regulation of actin filament depolymerization (GO:0030836)2.44343189
176regulation of developmental pigmentation (GO:0048070)2.44047446
177microtubule anchoring (GO:0034453)2.43345590
178positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.41322419
179branching involved in prostate gland morphogenesis (GO:0060442)2.40983503
180ER-nucleus signaling pathway (GO:0006984)2.40668656
181xenobiotic catabolic process (GO:0042178)2.40531834
182modified amino acid transport (GO:0072337)2.40146414
183cerebellar Purkinje cell differentiation (GO:0021702)2.39485590
184cAMP catabolic process (GO:0006198)2.38397794
185ER overload response (GO:0006983)2.38035773
186regulation of nuclease activity (GO:0032069)2.37810516
187detection of mechanical stimulus involved in sensory perception (GO:0050974)2.37664776
188cilium organization (GO:0044782)2.37308925
189phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35559946
190sphingoid metabolic process (GO:0046519)2.35186503
191cilium assembly (GO:0042384)2.34955687
192auditory receptor cell stereocilium organization (GO:0060088)2.34711607
193aromatic amino acid family metabolic process (GO:0009072)2.32369970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.33194111
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.01777781
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76013994
4GBX2_23144817_ChIP-Seq_PC3_Human3.41971003
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.35905564
6CDX2_20551321_ChIP-Seq_CACO-2_Human3.18981419
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10573186
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.03862386
9* SOX2_20726797_ChIP-Seq_SW620_Human2.91027876
10GATA4_25053715_ChIP-Seq_YYC3_Human2.89879787
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78879937
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77087536
13VDR_22108803_ChIP-Seq_LS180_Human2.66189088
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60662138
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53672123
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.51244863
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.50810205
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49198867
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.47211108
20EZH2_22144423_ChIP-Seq_EOC_Human2.47116329
21CLOCK_20551151_ChIP-Seq_293T_Human2.46349904
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43770460
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39941476
24ZNF274_21170338_ChIP-Seq_K562_Hela2.35836926
25CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31432170
26TAF15_26573619_Chip-Seq_HEK293_Human2.30791291
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.30766562
28ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28498674
29GATA6_25053715_ChIP-Seq_YYC3_Human2.25904790
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25898535
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20931780
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.19190328
33PPAR_26484153_Chip-Seq_NCI-H1993_Human2.16734493
34ESR2_21235772_ChIP-Seq_MCF-7_Human2.13973203
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.12868148
36IGF1R_20145208_ChIP-Seq_DFB_Human2.04182177
37* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00334847
38STAT3_23295773_ChIP-Seq_U87_Human1.99902853
39P300_19829295_ChIP-Seq_ESCs_Human1.97748528
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94371866
41* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93707477
42* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93707477
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.92542995
44SMAD4_21799915_ChIP-Seq_A2780_Human1.91097711
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.90717980
46ER_23166858_ChIP-Seq_MCF-7_Human1.89604219
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.89404567
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.88306280
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87235640
50CJUN_26792858_Chip-Seq_BT549_Human1.87094325
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83267957
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.83035802
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81590188
54AR_21909140_ChIP-Seq_LNCAP_Human1.79826392
55AR_21572438_ChIP-Seq_LNCaP_Human1.79620663
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76644293
57EWS_26573619_Chip-Seq_HEK293_Human1.76344346
58FUS_26573619_Chip-Seq_HEK293_Human1.75616442
59GATA1_22025678_ChIP-Seq_K562_Human1.75259762
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74964505
61* TCF4_23295773_ChIP-Seq_U87_Human1.73414242
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73000151
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70598235
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70388048
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67716124
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.65693281
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65068883
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60997538
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59305294
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59305294
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59149343
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.59051943
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58535951
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58179373
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56763447
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56581570
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.56522591
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55477699
79AR_25329375_ChIP-Seq_VCAP_Human1.54359984
80* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54227420
81* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54227420
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53664991
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53126108
84DROSHA_22980978_ChIP-Seq_HELA_Human1.52726557
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51965157
86CBP_20019798_ChIP-Seq_JUKART_Human1.51965157
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.50765754
88* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50121468
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49756041
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.48501196
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.42905450
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41459138
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39842418
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38386245
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.37350762
96* FOXA1_25552417_ChIP-Seq_VCAP_Human1.37265425
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37029093
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35881615
99TCF4_22108803_ChIP-Seq_LS180_Human1.35852969
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35771865
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.35153148
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34336630
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33949088
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33852279
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.33568182
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33362514
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32821565
108RUNX2_22187159_ChIP-Seq_PCA_Human1.32064714
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31559485
110KLF5_25053715_ChIP-Seq_YYC3_Human1.31412256
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.30271069
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29158026
113* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26919458
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26877261
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26829345
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26567188
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26329034
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.26134289
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25269792
120* EZH2_27294783_Chip-Seq_NPCs_Mouse1.24530235
121* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23401172
122ATF3_27146783_Chip-Seq_COLON_Human1.23167011
123* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23109887
124* FLI1_21867929_ChIP-Seq_TH2_Mouse1.21840389
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.21687186
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21350720
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.21228292
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.19384696
129* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18123150
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17758997
131BRD4_25478319_ChIP-Seq_HGPS_Human1.17615314
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17071480
133KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17046891
134KDM2B_26808549_Chip-Seq_REH_Human1.16646870
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16629871
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14523617
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13767820
138SMAD3_21741376_ChIP-Seq_HESCs_Human1.13201384
139REST_21632747_ChIP-Seq_MESCs_Mouse1.12598949
140* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12184776
141TP63_23658742_ChIP-Seq_EP156T_Human1.10666660
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10465370
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10308101
144CDX2_22108803_ChIP-Seq_LS180_Human1.09562572
145E2F1_18555785_Chip-Seq_ESCs_Mouse1.09525348
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09473562
147PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08554894
148P53_22387025_ChIP-Seq_ESCs_Mouse1.08060560
149P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06790977
150* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05204339
151TP53_18474530_ChIP-ChIP_U2OS_Human1.04594196
152* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03667481
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03552530
154* CRX_20693478_ChIP-Seq_RETINA_Mouse1.03224535
155SOX2_19829295_ChIP-Seq_ESCs_Human1.03011421
156NANOG_19829295_ChIP-Seq_ESCs_Human1.03011421
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02975033
158TP53_16413492_ChIP-PET_HCT116_Human1.02956209
159CBX2_27304074_Chip-Seq_ESCs_Mouse1.02716050
160* AR_19668381_ChIP-Seq_PC3_Human1.01964658
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01795190
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01792266
163* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00464180
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.99216848
165* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97770173
166FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97712685
167FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96707838
168CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94850976
169* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93587830
170TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93550685
171AHR_22903824_ChIP-Seq_MCF-7_Human0.93518159
172RACK7_27058665_Chip-Seq_MCF-7_Human0.93485243
173ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90751232
174Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90565609
175CHD1_26751641_Chip-Seq_LNCaP_Human0.90248704
176RXR_22108803_ChIP-Seq_LS180_Human0.84531040
177BCAT_22108803_ChIP-Seq_LS180_Human0.84387318
178TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82950963
179FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80917855
180TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78698218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.25386130
2MP0010234_abnormal_vibrissa_follicle4.37171445
3MP0008057_abnormal_DNA_replication4.33337750
4MP0005360_urolithiasis3.77999521
5MP0001666_abnormal_nutrient_absorption3.68928981
6MP0003646_muscle_fatigue3.38195928
7MP0004264_abnormal_extraembryonic_tissu3.23959872
8MP0002139_abnormal_hepatobiliary_system2.85821042
9MP0003252_abnormal_bile_duct2.78088735
10MP0009046_muscle_twitch2.56489098
11MP0001501_abnormal_sleep_pattern2.55409629
12MP0005365_abnormal_bile_salt2.50906244
13MP0005085_abnormal_gallbladder_physiolo2.50415100
14MP0003705_abnormal_hypodermis_morpholog2.49524136
15MP0003300_gastrointestinal_ulcer2.44959042
16MP0009384_cardiac_valve_regurgitation2.36600263
17MP0000462_abnormal_digestive_system2.36024364
18MP0006054_spinal_hemorrhage2.34827781
19MP0005551_abnormal_eye_electrophysiolog2.33089804
20MP0003183_abnormal_peptide_metabolism2.20863544
21MP0010352_gastrointestinal_tract_polyps2.17589986
22MP0000537_abnormal_urethra_morphology2.14802545
23MP0001968_abnormal_touch/_nociception2.10892588
24MP0005084_abnormal_gallbladder_morpholo1.95341424
25MP0008438_abnormal_cutaneous_collagen1.93697910
26MP0004043_abnormal_pH_regulation1.84053480
27MP0009745_abnormal_behavioral_response1.80006703
28MP0003890_abnormal_embryonic-extraembry1.76071922
29MP0005220_abnormal_exocrine_pancreas1.75515157
30MP0004272_abnormal_basement_membrane1.74491138
31MP0002736_abnormal_nociception_after1.73074127
32MP0008875_abnormal_xenobiotic_pharmacok1.71531435
33MP0003787_abnormal_imprinting1.70931162
34MP0008961_abnormal_basal_metabolism1.69884050
35MP0000013_abnormal_adipose_tissue1.69309236
36MP0002877_abnormal_melanocyte_morpholog1.68871270
37MP0008877_abnormal_DNA_methylation1.68284555
38MP0004130_abnormal_muscle_cell1.68006244
39MP0002876_abnormal_thyroid_physiology1.64727007
40MP0000538_abnormal_urinary_bladder1.64192653
41MP0005310_abnormal_salivary_gland1.64105947
42MP0009780_abnormal_chondrocyte_physiolo1.63776190
43MP0005275_abnormal_skin_tensile1.63449528
44MP0000678_abnormal_parathyroid_gland1.60397263
45MP0001486_abnormal_startle_reflex1.59236992
46MP0001485_abnormal_pinna_reflex1.58978572
47MP0003195_calcinosis1.58938573
48MP0003136_yellow_coat_color1.58634023
49MP0005174_abnormal_tail_pigmentation1.55565264
50MP0010386_abnormal_urinary_bladder1.52413415
51MP0004019_abnormal_vitamin_homeostasis1.52058927
52MP0002837_dystrophic_cardiac_calcinosis1.49435511
53MP0004142_abnormal_muscle_tone1.48049381
54MP0004145_abnormal_muscle_electrophysio1.47825053
55MP0009053_abnormal_anal_canal1.47190319
56MP0003868_abnormal_feces_composition1.47121041
57MP0000516_abnormal_urinary_system1.46638953
58MP0005367_renal/urinary_system_phenotyp1.46638953
59MP0002735_abnormal_chemical_nociception1.46630984
60MP0005646_abnormal_pituitary_gland1.46567654
61MP0003283_abnormal_digestive_organ1.44979949
62MP0004924_abnormal_behavior1.44354452
63MP0005386_behavior/neurological_phenoty1.44354452
64MP0005670_abnormal_white_adipose1.43227964
65MP0003950_abnormal_plasma_membrane1.43034681
66MP0005408_hypopigmentation1.42828570
67MP0002168_other_aberrant_phenotype1.42807002
68MP0002138_abnormal_hepatobiliary_system1.41888920
69MP0002009_preneoplasia1.40273862
70MP0006276_abnormal_autonomic_nervous1.40064644
71MP0009643_abnormal_urine_homeostasis1.39986157
72MP0002896_abnormal_bone_mineralization1.38806830
73MP0002060_abnormal_skin_morphology1.38087329
74MP0002272_abnormal_nervous_system1.37886167
75MP0002064_seizures1.37714290
76MP0001664_abnormal_digestion1.37022470
77MP0008872_abnormal_physiological_respon1.36831364
78MP0010678_abnormal_skin_adnexa1.36820019
79MP0003866_abnormal_defecation1.36541683
80MP0005253_abnormal_eye_physiology1.35064844
81MP0008004_abnormal_stomach_pH1.27634754
82MP0000613_abnormal_salivary_gland1.25744097
83MP0005645_abnormal_hypothalamus_physiol1.22258256
84MP0002067_abnormal_sensory_capabilities1.21730105
85MP0005266_abnormal_metabolism1.21061745
86MP0002572_abnormal_emotion/affect_behav1.20813669
87MP0003941_abnormal_skin_development1.17749212
88MP0001765_abnormal_ion_homeostasis1.15277328
89MP0001756_abnormal_urination1.15175530
90MP0002098_abnormal_vibrissa_morphology1.15166357
91MP0002638_abnormal_pupillary_reflex1.14633213
92MP0005257_abnormal_intraocular_pressure1.13579373
93MP0001944_abnormal_pancreas_morphology1.13514885
94MP0000477_abnormal_intestine_morphology1.13354570
95MP0010155_abnormal_intestine_physiology1.10218249
96MP0000230_abnormal_systemic_arterial1.10080892
97MP0001970_abnormal_pain_threshold1.10008012
98MP0003566_abnormal_cell_adhesion1.09912504
99MP0002557_abnormal_social/conspecific_i1.09884172
100MP0001984_abnormal_olfaction1.09751277
101MP0003635_abnormal_synaptic_transmissio1.08375899
102MP0004215_abnormal_myocardial_fiber1.07882551
103MP0002796_impaired_skin_barrier1.06855400
104MP0005083_abnormal_biliary_tract1.06183624
105MP0002733_abnormal_thermal_nociception1.06027894
106MP0005187_abnormal_penis_morphology1.06021497
107MP0005023_abnormal_wound_healing1.05698352
108MP0000566_synostosis1.04964969
109MP0000631_abnormal_neuroendocrine_gland1.04119476
110MP0010329_abnormal_lipoprotein_level1.03987036
111MP0001986_abnormal_taste_sensitivity1.03745552
112MP0003453_abnormal_keratinocyte_physiol1.02512282
113MP0010030_abnormal_orbit_morphology1.01587575
114MP0000003_abnormal_adipose_tissue1.01541481
115MP0004147_increased_porphyrin_level1.01533050
116MP0003633_abnormal_nervous_system1.00490422
117MP0002295_abnormal_pulmonary_circulatio1.00239620
118MP0004782_abnormal_surfactant_physiolog0.99363025
119MP0005636_abnormal_mineral_homeostasis0.99175795
120MP0005381_digestive/alimentary_phenotyp0.98585530
121MP0005395_other_phenotype0.96736385
122MP0001849_ear_inflammation0.96450446
123MP0002063_abnormal_learning/memory/cond0.96271536
124MP0000371_diluted_coat_color0.96001582
125MP0005503_abnormal_tendon_morphology0.95065655
126MP0005076_abnormal_cell_differentiation0.95018859
127MP0005167_abnormal_blood-brain_barrier0.94334664
128MP0002928_abnormal_bile_duct0.93240576
129MP0000490_abnormal_crypts_of0.93022859
130MP0003879_abnormal_hair_cell0.91892056
131MP0001873_stomach_inflammation0.91733218
132MP0003880_abnormal_central_pattern0.91090929
133MP0005332_abnormal_amino_acid0.90474094
134MP0009115_abnormal_fat_cell0.90259377
135MP0002102_abnormal_ear_morphology0.89472823
136MP0005379_endocrine/exocrine_gland_phen0.87304048
137MP0003937_abnormal_limbs/digits/tail_de0.86592310
138MP0003806_abnormal_nucleotide_metabolis0.86587675
139MP0002938_white_spotting0.86502003
140MP0009840_abnormal_foam_cell0.86206051
141MP0002229_neurodegeneration0.85935738
142MP0005448_abnormal_energy_balance0.85614705
143MP0002254_reproductive_system_inflammat0.85121546
144MP0002693_abnormal_pancreas_physiology0.85053142
145MP0005171_absent_coat_pigmentation0.83967812
146MP0000163_abnormal_cartilage_morphology0.83190377
147MP0003137_abnormal_impulse_conducting0.82797839
148MP0002734_abnormal_mechanical_nocicepti0.82627392
149MP0000467_abnormal_esophagus_morphology0.82154119
150MP0004085_abnormal_heartbeat0.81496790
151MP0000778_abnormal_nervous_system0.81100750
152MP0003631_nervous_system_phenotype0.80825735
153MP0002095_abnormal_skin_pigmentation0.80354395
154MP0005248_abnormal_Harderian_gland0.79931010
155MP0000427_abnormal_hair_cycle0.79349253
156MP0001663_abnormal_digestive_system0.79317007
157MP0000534_abnormal_ureter_morphology0.78703842
158MP0001216_abnormal_epidermal_layer0.78459108
159MP0005195_abnormal_posterior_eye0.77024526
160MP0001881_abnormal_mammary_gland0.76696310
161MP0000762_abnormal_tongue_morphology0.75588558
162MP0004742_abnormal_vestibular_system0.75462377
163MP0001324_abnormal_eye_pigmentation0.74989396
164MP0002136_abnormal_kidney_physiology0.73707032
165MP0003632_abnormal_nervous_system0.73649352
166MP0000372_irregular_coat_pigmentation0.72880861
167MP0003045_fibrosis0.72834879
168MP0000470_abnormal_stomach_morphology0.72161724
169MP0002277_abnormal_respiratory_mucosa0.71799488
170MP0003385_abnormal_body_wall0.71785562
171MP0003943_abnormal_hepatobiliary_system0.71366396
172MP0010368_abnormal_lymphatic_system0.71214495
173MP0009697_abnormal_copulation0.70452613
174MP0002166_altered_tumor_susceptibility0.70393622
175MP0005647_abnormal_sex_gland0.70098887
176MP0001440_abnormal_grooming_behavior0.69961440
177MP0000383_abnormal_hair_follicle0.69260189
178MP0000579_abnormal_nail_morphology0.67882497
179MP0000627_abnormal_mammary_gland0.67439482

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.68290787
2Right ventricular cardiomyopathy (HP:0011663)5.32994928
3Ileus (HP:0002595)5.13830622
4Hyperventilation (HP:0002883)5.12484617
5Gaze-evoked nystagmus (HP:0000640)4.37855825
6Pancreatic cysts (HP:0001737)4.36912097
7Progressive cerebellar ataxia (HP:0002073)4.36081759
8Protruding tongue (HP:0010808)3.93468963
9Pancreatic fibrosis (HP:0100732)3.81803851
10Hydroxyprolinuria (HP:0003080)3.75456053
11Abnormality of proline metabolism (HP:0010907)3.75456053
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.74752899
13True hermaphroditism (HP:0010459)3.68031098
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.56204909
15Atrophic scars (HP:0001075)3.55058542
16Clumsiness (HP:0002312)3.46670935
17Hypoglycemic coma (HP:0001325)3.42051648
18Aplasia/Hypoplasia of the tibia (HP:0005772)3.35554535
19Conjugated hyperbilirubinemia (HP:0002908)3.31403085
20Symptomatic seizures (HP:0011145)3.30892752
21Abdominal distention (HP:0003270)3.30449919
22Chronic hepatic failure (HP:0100626)3.29628070
23Fair hair (HP:0002286)3.23915619
24Abnormality of the renal cortex (HP:0011035)3.21926916
25Hypoglycemic seizures (HP:0002173)3.19784777
26Molar tooth sign on MRI (HP:0002419)3.18675366
27Abnormality of midbrain morphology (HP:0002418)3.18675366
28Rectal prolapse (HP:0002035)3.14064252
29Abnormal pancreas size (HP:0012094)3.05482358
30Cystic liver disease (HP:0006706)3.01569124
31Micronodular cirrhosis (HP:0001413)3.01439545
32Congenital stationary night blindness (HP:0007642)3.00752168
33Hyperglycemia (HP:0003074)3.00167459
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.00135983
35Febrile seizures (HP:0002373)2.94821790
36Hyperinsulinemic hypoglycemia (HP:0000825)2.94287612
37Abnormal biliary tract morphology (HP:0012440)2.93772278
38Nephronophthisis (HP:0000090)2.93294391
39Fat malabsorption (HP:0002630)2.90855330
40Abnormality of the renal medulla (HP:0100957)2.90835276
41Attenuation of retinal blood vessels (HP:0007843)2.83913278
42Malnutrition (HP:0004395)2.80437159
43Exocrine pancreatic insufficiency (HP:0001738)2.77938226
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.75448326
45Dysmetric saccades (HP:0000641)2.74218641
46Absent speech (HP:0001344)2.74023195
47Broad-based gait (HP:0002136)2.71451182
48Decreased circulating renin level (HP:0003351)2.69619098
49Tubular atrophy (HP:0000092)2.69604916
50Onycholysis (HP:0001806)2.68544664
51Aortic aneurysm (HP:0004942)2.66208802
52Abnormality of chloride homeostasis (HP:0011422)2.62976928
53Congenital sensorineural hearing impairment (HP:0008527)2.62694608
54Hypoplastic ischia (HP:0003175)2.59982443
55Hyperactive renin-angiotensin system (HP:0000841)2.59772306
56Hypobetalipoproteinemia (HP:0003563)2.58891972
57Abnormality of the ischium (HP:0003174)2.58853396
58Generalized hypopigmentation of hair (HP:0011358)2.57676012
59Thin bony cortex (HP:0002753)2.54624779
60Medial flaring of the eyebrow (HP:0010747)2.54176343
61Cupped ribs (HP:0000887)2.50716509
62Intrahepatic cholestasis (HP:0001406)2.49568011
63Abnormality of purine metabolism (HP:0004352)2.49311542
64Fragile skin (HP:0001030)2.48096192
65Cervical subluxation (HP:0003308)2.46966940
66Widely spaced teeth (HP:0000687)2.46234267
67Chronic diarrhea (HP:0002028)2.43526592
68Abnormality of the intrinsic pathway (HP:0010989)2.43494639
69Widely patent fontanelles and sutures (HP:0004492)2.42637512
70Abnormal foot bone ossification (HP:0010675)2.41363060
71Mildly elevated creatine phosphokinase (HP:0008180)2.39437356
72Dialeptic seizures (HP:0011146)2.39168383
73Inability to walk (HP:0002540)2.36690863
74Central scotoma (HP:0000603)2.36512959
75Preaxial foot polydactyly (HP:0001841)2.34967964
76Milia (HP:0001056)2.34154344
77Premature rupture of membranes (HP:0001788)2.33342393
78Focal seizures (HP:0007359)2.30387060
79Insulin-resistant diabetes mellitus (HP:0000831)2.29554787
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29492962
81Patellar aplasia (HP:0006443)2.29162317
82Gastrointestinal dysmotility (HP:0002579)2.28764135
83Hyperparathyroidism (HP:0000843)2.27941263
84Abnormality of the distal phalanges of the toes (HP:0010182)2.27594933
85Progressive inability to walk (HP:0002505)2.27583575
86Aortic dissection (HP:0002647)2.27550441
87Abnormality of the labia majora (HP:0012881)2.27356982
88Bony spicule pigmentary retinopathy (HP:0007737)2.26879363
89Furrowed tongue (HP:0000221)2.23269354
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.23267845
91Facial shape deformation (HP:0011334)2.22992666
92Potter facies (HP:0002009)2.22992666
93Subacute progressive viral hepatitis (HP:0006572)2.22516150
94Glycosuria (HP:0003076)2.21817406
95Abnormality of urine glucose concentration (HP:0011016)2.21817406
96Abnormal glucose tolerance (HP:0001952)2.21297533
97Congenital hepatic fibrosis (HP:0002612)2.20260908
98Absence seizures (HP:0002121)2.18686387
99Biliary tract neoplasm (HP:0100574)2.18032101
100Large for gestational age (HP:0001520)2.16555792
101Abolished electroretinogram (ERG) (HP:0000550)2.16375422
102Gait imbalance (HP:0002141)2.15638293
103Urinary bladder sphincter dysfunction (HP:0002839)2.14707158
104Increased cerebral lipofuscin (HP:0011813)2.14531127
105Congenital primary aphakia (HP:0007707)2.10496438
106Flat acetabular roof (HP:0003180)2.10086780
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07571308
108Abnormality of alanine metabolism (HP:0010916)2.07571308
109Hyperalaninemia (HP:0003348)2.07571308
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07221381
111Proximal tubulopathy (HP:0000114)2.07147713
112Genital tract atresia (HP:0001827)2.07055306
113Poor coordination (HP:0002370)2.06657401
114Abnormality of the gastric mucosa (HP:0004295)2.06159111
115Abnormal tarsal ossification (HP:0008369)2.04590788
116Aplasia/Hypoplasia of the patella (HP:0006498)2.04389202
117Focal segmental glomerulosclerosis (HP:0000097)2.03679179
118Generalized aminoaciduria (HP:0002909)2.02928938
119Cerebellar dysplasia (HP:0007033)2.02719067
120Birth length less than 3rd percentile (HP:0003561)2.00657494
121Polydipsia (HP:0001959)2.00242358
122Abnormal drinking behavior (HP:0030082)2.00242358
123Volvulus (HP:0002580)1.99935041
124Vaginal atresia (HP:0000148)1.99623223
125Progressive sensorineural hearing impairment (HP:0000408)1.99610654
126Stomach cancer (HP:0012126)1.99553035
127Palpitations (HP:0001962)1.98183519
128Late onset (HP:0003584)1.97549682
129Acanthocytosis (HP:0001927)1.95451060
130Hyperkalemia (HP:0002153)1.94236060
131Renal cortical cysts (HP:0000803)1.94044433
132Short foot (HP:0001773)1.93853444
133Tibial bowing (HP:0002982)1.93280769
134Absent/shortened dynein arms (HP:0200106)1.92391081
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.92391081
136Abnormal hemoglobin (HP:0011902)1.92384983
137Drooling (HP:0002307)1.91682319
138Ketoacidosis (HP:0001993)1.91530041
139Cupped ear (HP:0000378)1.91248945
140Gout (HP:0001997)1.91202055
141Abnormality of the pancreatic islet cells (HP:0006476)1.90929632
142Abnormality of endocrine pancreas physiology (HP:0012093)1.90929632
143Hypokalemia (HP:0002900)1.90480076
144Ureteral obstruction (HP:0006000)1.90082775
145Type II lissencephaly (HP:0007260)1.89608766
146Protrusio acetabuli (HP:0003179)1.89204378
147Abnormality of small intestinal villus morphology (HP:0011472)1.89190143
148Villous atrophy (HP:0011473)1.89190143
149Hypoplasia of dental enamel (HP:0006297)1.89022047
150Hypolipoproteinemia (HP:0010981)1.88324972
151Urinary glycosaminoglycan excretion (HP:0003541)1.86776087
152Mucopolysacchariduria (HP:0008155)1.86776087
153Sclerocornea (HP:0000647)1.85755209
154Increased corneal curvature (HP:0100692)1.85662409
155Keratoconus (HP:0000563)1.85662409
156Hypoplasia of the uterus (HP:0000013)1.84688748
157Femoral bowing (HP:0002980)1.83863352
158Nephrogenic diabetes insipidus (HP:0009806)1.81888562
159Chorioretinal atrophy (HP:0000533)1.81886829
160Insulin resistance (HP:0000855)1.81507750
161Pterygium (HP:0001059)1.81378186
162Hyperphosphatemia (HP:0002905)1.81173394
163Small hand (HP:0200055)1.81096661
164Dehydration (HP:0001944)1.80330213
165Impaired smooth pursuit (HP:0007772)1.80317540
166Highly arched eyebrow (HP:0002553)1.79921064
167Scotoma (HP:0000575)1.79877986
168Anencephaly (HP:0002323)1.79576899
169Tented upper lip vermilion (HP:0010804)1.79088774
170Absent radius (HP:0003974)1.78785555
171Abnormal ciliary motility (HP:0012262)1.78777444
172Postaxial foot polydactyly (HP:0001830)1.78131964
173Wide cranial sutures (HP:0010537)1.77844827
174Abnormality of the nasal septum (HP:0000419)1.77681103
175Preaxial hand polydactyly (HP:0001177)1.77343018
176Hypoplastic labia majora (HP:0000059)1.76249740
177Abnormality of the pubic bones (HP:0003172)1.75776254
178Pili torti (HP:0003777)1.75009051
179Pancreatic islet-cell hyperplasia (HP:0004510)1.74234377
180Blue irides (HP:0000635)1.74131059
181Male pseudohermaphroditism (HP:0000037)1.73936638
182Xanthomatosis (HP:0000991)1.73442341
183Abnormality of macular pigmentation (HP:0008002)1.73405233
184Plantar hyperkeratosis (HP:0007556)1.72974283
185Truncal obesity (HP:0001956)1.72778937
186Focal motor seizures (HP:0011153)1.72700004
187Pigmentary retinal degeneration (HP:0001146)1.72284810
188Facial diplegia (HP:0001349)1.72198510
189Aplasia involving forearm bones (HP:0009822)1.71837516
190Esophageal varix (HP:0002040)1.71759977
191Aneurysm (HP:0002617)1.71508512
192Ureteral stenosis (HP:0000071)1.71444390
193Thoracolumbar scoliosis (HP:0002944)1.70938234
194Curly hair (HP:0002212)1.70812479
195Increased purine levels (HP:0004368)1.70366091
196Hyperuricemia (HP:0002149)1.70366091
197Natal tooth (HP:0000695)1.69576283
198Woolly hair (HP:0002224)1.69525124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.05741804
2LMTK24.09862692
3EPHA23.88914681
4LATS13.67638297
5MST43.27211398
6MST1R3.19040628
7NUAK12.91325682
8MAP3K22.73007455
9CASK2.62081837
10AKT32.56931445
11ADRBK22.55875807
12INSRR2.48994499
13PTK62.31314912
14TAOK32.30804153
15MKNK22.18409613
16PIK3CG2.18344041
17FER2.12057131
18ERN12.10618558
19PRKG21.99902705
20PIK3CA1.98563087
21MAP2K21.91799842
22OXSR11.91258566
23MET1.87856714
24RIPK11.82370076
25MAPK131.81834462
26GRK11.80841932
27TESK11.79313763
28NTRK31.77439412
29PTK21.71748650
30DDR21.70219832
31MYLK1.68302264
32MAP3K31.67479936
33EPHB21.60710893
34WNK41.56870942
35ADRBK11.54161303
36STK38L1.52956531
37CAMK1G1.51022104
38EPHA31.45343388
39MAPK151.43870635
40CAMK1D1.40361183
41SGK21.39335380
42MAP3K41.38530045
43* FRK1.34627351
44PDGFRA1.34168954
45TNIK1.28093781
46NME11.27290210
47SIK11.25255396
48STK31.23794560
49ZAK1.23533017
50PAK31.18426943
51PINK11.17966420
52MAP3K71.17730009
53CDK121.16261947
54SIK21.15477725
55STK381.12636943
56BRD41.11142936
57TTN1.10642736
58STK391.07659561
59MAP2K11.07490397
60PTK2B1.07247185
61PASK1.06116989
62MAP4K21.02796504
63DAPK21.01448418
64PRKCI1.00652688
65STK100.99887622
66MARK10.96578281
67TRPM70.96045420
68TEC0.94530879
69BRSK20.91711019
70PAK20.87823499
71ERBB30.87553104
72CAMKK20.87467277
73SCYL20.86998045
74SGK2230.83687020
75SGK4940.83687020
76ERBB20.83609166
77WNK30.83083767
78PNCK0.82778245
79NEK90.82619010
80LIMK10.82529590
81ERBB40.82269831
82TLK10.79661716
83RPS6KB20.79557445
84PAK40.78854524
85IRAK30.77979870
86OBSCN0.76875737
87RPS6KA40.76076342
88PRKCG0.75824870
89FGFR20.71838066
90TXK0.71533149
91LRRK20.69183420
92IRAK10.68732812
93BLK0.68588241
94CAMK10.67708178
95PDK20.66619293
96MKNK10.66582618
97STK110.65341336
98CAMK40.65080109
99WNK10.64915527
100SGK10.64845381
101EPHA40.62441444
102CHUK0.61917482
103DYRK1B0.61896823
104CAMK2A0.61761346
105SGK30.61213574
106ROCK10.60184556
107MAPKAPK30.60170774
108NLK0.59665587
109DMPK0.58350229
110TNK20.57865750
111BCKDK0.56141497
112MAP3K10.56139494
113PKN10.54970737
114PDGFRB0.54763422
115TRIB30.54301230
116NEK20.53758185
117MAP2K60.52178645
118CSNK1D0.51247060
119PRKAA20.51044452
120BMX0.47695827
121MAPK110.46648107
122MAP3K80.45886464
123CSNK1A1L0.44916580
124AURKB0.43901852
125MARK30.43660196
126PLK20.43536653
127EPHB10.43272392
128BMPR1B0.43149936
129CDK30.40260548
130NTRK20.39962174
131CDC42BPA0.39860927
132RPS6KA30.39164729
133PBK0.38821056
134PRKG10.38766332
135PRKACA0.37522635
136KIT0.37407283
137PRKCE0.36781006
138NEK60.36471597
139PRKCH0.36224319
140PRKCZ0.36017880
141IKBKB0.35651590
142GSK3B0.35493818
143MUSK0.34606051
144PRKAA10.34069891
145ITK0.33208688
146PRKACB0.33100335
147PRKCB0.33098267
148GSK3A0.32853192
149CAMK2D0.32694719
150MAPK80.31905814
151IGF1R0.30659221
152MTOR0.30401813
153FLT30.29956087
154TTK0.29858942
155MAP3K140.28255438
156INSR0.27670767
157MELK0.27308373
158EIF2AK30.27273200
159CDK60.27185251
160MAPKAPK20.27010102
161HIPK20.26700842
162FGFR10.26048211
163TGFBR10.25405292
164PKN20.25077835
165JAK30.22753560
166PIM20.22256682
167CAMK2G0.21745294
168CSNK1A10.21576103
169EEF2K0.21452758

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.56663362
2Sulfur metabolism_Homo sapiens_hsa009204.34387727
3Fat digestion and absorption_Homo sapiens_hsa049753.62665413
4Mineral absorption_Homo sapiens_hsa049782.88177049
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49981396
6Renin-angiotensin system_Homo sapiens_hsa046142.48844075
7Nicotine addiction_Homo sapiens_hsa050332.35155163
8Protein digestion and absorption_Homo sapiens_hsa049742.29484051
9Protein export_Homo sapiens_hsa030602.18082382
10Vitamin digestion and absorption_Homo sapiens_hsa049772.11097963
11Folate biosynthesis_Homo sapiens_hsa007902.02466149
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99891403
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99369621
14Phototransduction_Homo sapiens_hsa047441.98479503
15Starch and sucrose metabolism_Homo sapiens_hsa005001.98239022
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92777986
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92590001
18Taste transduction_Homo sapiens_hsa047421.82923271
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79503096
20Galactose metabolism_Homo sapiens_hsa000521.77829369
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72644552
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72231783
23Caffeine metabolism_Homo sapiens_hsa002321.62673543
24Dorso-ventral axis formation_Homo sapiens_hsa043201.60223754
25Lysine degradation_Homo sapiens_hsa003101.58840809
26Ether lipid metabolism_Homo sapiens_hsa005651.53022785
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53019596
28Bile secretion_Homo sapiens_hsa049761.51820631
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50421307
30Morphine addiction_Homo sapiens_hsa050321.49961508
31Glutamatergic synapse_Homo sapiens_hsa047241.43262974
32Selenocompound metabolism_Homo sapiens_hsa004501.40903403
33Histidine metabolism_Homo sapiens_hsa003401.40145562
34Circadian entrainment_Homo sapiens_hsa047131.37424478
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36194416
36Olfactory transduction_Homo sapiens_hsa047401.33040028
37Glutathione metabolism_Homo sapiens_hsa004801.31338834
38Serotonergic synapse_Homo sapiens_hsa047261.29963136
39Tryptophan metabolism_Homo sapiens_hsa003801.29734533
40Adherens junction_Homo sapiens_hsa045201.29345925
41Calcium signaling pathway_Homo sapiens_hsa040201.28920473
42Salivary secretion_Homo sapiens_hsa049701.27410302
43Fatty acid degradation_Homo sapiens_hsa000711.25981824
44Tight junction_Homo sapiens_hsa045301.22373210
45ECM-receptor interaction_Homo sapiens_hsa045121.22086424
46Ovarian steroidogenesis_Homo sapiens_hsa049131.20122165
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18858987
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17438868
49Pancreatic secretion_Homo sapiens_hsa049721.17434885
50N-Glycan biosynthesis_Homo sapiens_hsa005101.16060401
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14265437
52Vibrio cholerae infection_Homo sapiens_hsa051101.13067478
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12765921
54Chemical carcinogenesis_Homo sapiens_hsa052041.09363610
55GABAergic synapse_Homo sapiens_hsa047271.08495543
56Fructose and mannose metabolism_Homo sapiens_hsa000511.07686496
57Bladder cancer_Homo sapiens_hsa052191.07455925
58Homologous recombination_Homo sapiens_hsa034401.06853415
59ABC transporters_Homo sapiens_hsa020101.04296197
60Linoleic acid metabolism_Homo sapiens_hsa005911.03734792
61Thyroid hormone synthesis_Homo sapiens_hsa049180.98916387
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97569051
63Circadian rhythm_Homo sapiens_hsa047100.97250867
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96698365
65Fatty acid biosynthesis_Homo sapiens_hsa000610.94965058
66Sphingolipid metabolism_Homo sapiens_hsa006000.94829503
67Fanconi anemia pathway_Homo sapiens_hsa034600.94149872
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92118477
69Cholinergic synapse_Homo sapiens_hsa047250.90844172
70Long-term depression_Homo sapiens_hsa047300.90144844
71Small cell lung cancer_Homo sapiens_hsa052220.88261244
72Focal adhesion_Homo sapiens_hsa045100.88202157
73Renin secretion_Homo sapiens_hsa049240.87846080
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87728191
75PPAR signaling pathway_Homo sapiens_hsa033200.87325637
76Arachidonic acid metabolism_Homo sapiens_hsa005900.87010001
77Gastric acid secretion_Homo sapiens_hsa049710.86988361
78cAMP signaling pathway_Homo sapiens_hsa040240.86076500
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83582725
80Oxytocin signaling pathway_Homo sapiens_hsa049210.83445490
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.80945703
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77873311
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76980362
84Thyroid cancer_Homo sapiens_hsa052160.75586363
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.75489410
86Hippo signaling pathway_Homo sapiens_hsa043900.74662993
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73423464
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71662012
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.71239531
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69950343
91Amoebiasis_Homo sapiens_hsa051460.69639867
92Dopaminergic synapse_Homo sapiens_hsa047280.69280239
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67908331
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67863583
95Phenylalanine metabolism_Homo sapiens_hsa003600.67445021
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66937574
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.64634576
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64304561
99Proteoglycans in cancer_Homo sapiens_hsa052050.62887606
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62523595
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.62148340
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61395258
103TGF-beta signaling pathway_Homo sapiens_hsa043500.61004198
104Retinol metabolism_Homo sapiens_hsa008300.59793600
105Arginine and proline metabolism_Homo sapiens_hsa003300.59754784
106Glycerolipid metabolism_Homo sapiens_hsa005610.58900966
107Other glycan degradation_Homo sapiens_hsa005110.57613471
108Arginine biosynthesis_Homo sapiens_hsa002200.57202902
109Prostate cancer_Homo sapiens_hsa052150.56704495
110Butanoate metabolism_Homo sapiens_hsa006500.55877732
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.54994838
112Peroxisome_Homo sapiens_hsa041460.53526354
113beta-Alanine metabolism_Homo sapiens_hsa004100.50568501
114FoxO signaling pathway_Homo sapiens_hsa040680.50319581
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49563639
116Platelet activation_Homo sapiens_hsa046110.49269461
117Propanoate metabolism_Homo sapiens_hsa006400.48724367
118Complement and coagulation cascades_Homo sapiens_hsa046100.48463434
119Nitrogen metabolism_Homo sapiens_hsa009100.47700559
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46257721
121Hepatitis C_Homo sapiens_hsa051600.44842006
122Legionellosis_Homo sapiens_hsa051340.44756374
123Amphetamine addiction_Homo sapiens_hsa050310.44330504
124Endometrial cancer_Homo sapiens_hsa052130.44113120
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43983444
126Choline metabolism in cancer_Homo sapiens_hsa052310.43137768
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43065635
128Tyrosine metabolism_Homo sapiens_hsa003500.42142619
129Insulin secretion_Homo sapiens_hsa049110.41623589
130Type II diabetes mellitus_Homo sapiens_hsa049300.41527991
131Insulin resistance_Homo sapiens_hsa049310.40482619
132Cocaine addiction_Homo sapiens_hsa050300.40091993
133Fatty acid metabolism_Homo sapiens_hsa012120.37832744
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35837793
135Graft-versus-host disease_Homo sapiens_hsa053320.35710111
136Ras signaling pathway_Homo sapiens_hsa040140.34898220
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.33170711
138Toxoplasmosis_Homo sapiens_hsa051450.31157822
139MicroRNAs in cancer_Homo sapiens_hsa052060.30949108
140TNF signaling pathway_Homo sapiens_hsa046680.30850903
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.29999715
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29864181
143Basal cell carcinoma_Homo sapiens_hsa052170.29275061
144Prolactin signaling pathway_Homo sapiens_hsa049170.28654520
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27753395
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.24820247
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24559830
148Steroid biosynthesis_Homo sapiens_hsa001000.18894991
149Metabolic pathways_Homo sapiens_hsa011000.18850910
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.18514338
151Pyruvate metabolism_Homo sapiens_hsa006200.17948980

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