FRMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in visual perception (GO:0050908)6.20636524
2detection of light stimulus involved in sensory perception (GO:0050962)6.20636524
3synaptic vesicle exocytosis (GO:0016079)5.82146612
4protein localization to synapse (GO:0035418)5.49135211
5negative regulation of cytosolic calcium ion concentration (GO:0051481)5.25899589
6protein neddylation (GO:0045116)5.25149815
7response to pheromone (GO:0019236)5.24084628
8thrombin receptor signaling pathway (GO:0070493)5.10382559
9gamma-aminobutyric acid signaling pathway (GO:0007214)4.94941975
10regulation of platelet aggregation (GO:0090330)4.94089458
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.87390568
12negative regulation of homotypic cell-cell adhesion (GO:0034111)4.75015528
13neuron cell-cell adhesion (GO:0007158)4.72555226
14negative regulation of protein localization to cell surface (GO:2000009)4.71079142
15neutrophil activation involved in immune response (GO:0002283)4.65966309
16vocalization behavior (GO:0071625)4.53850469
17innervation (GO:0060384)4.52703192
18cellular potassium ion homeostasis (GO:0030007)4.52369044
19regulation of synaptic vesicle exocytosis (GO:2000300)4.51570712
20positive regulation of endothelial cell differentiation (GO:0045603)4.48551007
21adenosine receptor signaling pathway (GO:0001973)4.48075672
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46266033
23relaxation of smooth muscle (GO:0044557)4.43914477
24sodium ion export (GO:0071436)4.43017004
25synaptic vesicle endocytosis (GO:0048488)4.39696517
26positive regulation of synapse maturation (GO:0090129)4.35737183
27negative regulation of heart rate (GO:0010459)4.35216904
28retinal rod cell development (GO:0046548)4.34516973
29regulation of platelet activation (GO:0010543)4.31900344
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.24553932
31membrane depolarization during action potential (GO:0086010)4.18731002
32cell migration in hindbrain (GO:0021535)4.11354865
33regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08414872
34regulation of integrin-mediated signaling pathway (GO:2001044)4.08305761
35negative regulation of platelet activation (GO:0010544)4.07109954
36positive regulation of receptor recycling (GO:0001921)4.05233091
37regulation of lipoprotein metabolic process (GO:0050746)4.03702206
38mating behavior (GO:0007617)4.03536480
39blood coagulation, intrinsic pathway (GO:0007597)4.01930164
40negative regulation of norepinephrine secretion (GO:0010700)4.00327021
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.99249620
42urinary tract smooth muscle contraction (GO:0014848)3.98711092
43potassium ion homeostasis (GO:0055075)3.92897916
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.88427396
45muscle filament sliding (GO:0030049)3.82902296
46actin-myosin filament sliding (GO:0033275)3.82902296
47positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.80643876
48regulation of synapse maturation (GO:0090128)3.79856375
49regulation of synaptic vesicle transport (GO:1902803)3.78700201
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74737332
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.71252727
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.69528498
53glutamate secretion (GO:0014047)3.66306080
54synapse assembly (GO:0007416)3.65889842
55sarcoplasmic reticulum calcium ion transport (GO:0070296)3.65194490
56negative regulation of heart contraction (GO:0045822)3.63317646
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.63034474
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62357250
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61635910
60platelet aggregation (GO:0070527)3.53976706
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.53799226
62leukocyte migration involved in inflammatory response (GO:0002523)3.53212322
63striatum development (GO:0021756)3.53206531
64retinal ganglion cell axon guidance (GO:0031290)3.52882428
65cell communication by electrical coupling (GO:0010644)3.51370214
66synaptic vesicle maturation (GO:0016188)3.49598997
67glutamate receptor signaling pathway (GO:0007215)3.49207246
68negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.44155233
69actin-mediated cell contraction (GO:0070252)3.43756255
70synaptic vesicle transport (GO:0048489)3.43174763
71establishment of synaptic vesicle localization (GO:0097480)3.43174763
72retinal cone cell development (GO:0046549)3.41066447
73detection of temperature stimulus (GO:0016048)3.40989307
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39268485
75membrane hyperpolarization (GO:0060081)3.38129900
76detection of temperature stimulus involved in sensory perception (GO:0050961)3.36816893
77detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.36816893
78regulation of endothelial cell differentiation (GO:0045601)3.35498476
79neurotransmitter secretion (GO:0007269)3.34984681
80regulation of cAMP-dependent protein kinase activity (GO:2000479)3.34280347
81prepulse inhibition (GO:0060134)3.34128648
82positive regulation of potassium ion transmembrane transport (GO:1901381)3.34024783
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.33928360
84regulation of receptor recycling (GO:0001919)3.33653623
85exploration behavior (GO:0035640)3.32659530
86relaxation of muscle (GO:0090075)3.32044048
87neuronal action potential (GO:0019228)3.30248153
88neurotransmitter-gated ion channel clustering (GO:0072578)3.29958413
89regulation of synapse structural plasticity (GO:0051823)3.28149814
90negative regulation of appetite (GO:0032099)3.27407241
91negative regulation of response to food (GO:0032096)3.27407241
92neurofilament cytoskeleton organization (GO:0060052)3.26196466
93regulation of neurotransmitter secretion (GO:0046928)3.25935913
94calcium ion import (GO:0070509)3.24693968
95cerebellar Purkinje cell differentiation (GO:0021702)3.24341298
96cellular sodium ion homeostasis (GO:0006883)3.22712332
97negative regulation of thymocyte apoptotic process (GO:0070244)3.21924265
98polyamine biosynthetic process (GO:0006596)3.21497380
99platelet degranulation (GO:0002576)3.21426311
100low-density lipoprotein particle remodeling (GO:0034374)3.20882088
101neuron-neuron synaptic transmission (GO:0007270)3.20845450
102regulation of glutamate receptor signaling pathway (GO:1900449)3.19439524
103positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.19296914
104postsynaptic membrane organization (GO:0001941)3.15648010
105cellular response to epinephrine stimulus (GO:0071872)3.15351014
106positive regulation of cAMP-mediated signaling (GO:0043950)3.14826600
107phospholipid homeostasis (GO:0055091)3.12890495
108presynaptic membrane assembly (GO:0097105)3.11480469
109long-term synaptic potentiation (GO:0060291)3.10240813
110long-chain fatty acid biosynthetic process (GO:0042759)3.09196480
111axon cargo transport (GO:0008088)3.08915198
112regulation of voltage-gated calcium channel activity (GO:1901385)3.08684175
113G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.08145343
114relaxation of cardiac muscle (GO:0055119)3.07721771
115activation of protein kinase A activity (GO:0034199)3.07287308
116regulation of neurotransmitter transport (GO:0051588)3.07239518
117response to epinephrine (GO:0071871)3.06593849
118synaptic vesicle docking involved in exocytosis (GO:0016081)3.06120169
119sarcomere organization (GO:0045214)3.05996508
120regulation of skeletal muscle contraction (GO:0014819)3.05421696
121neurotransmitter transport (GO:0006836)3.04635235
122pyrimidine nucleobase catabolic process (GO:0006208)3.02649462
123neuronal action potential propagation (GO:0019227)3.01962216
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01404204
125positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01244715
126dendrite morphogenesis (GO:0048813)3.00623235
127negative regulation of calcium ion transmembrane transport (GO:1903170)3.00566471
128negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.00566471
129regulation of Golgi to plasma membrane protein transport (GO:0042996)3.00094896
130establishment of mitochondrion localization (GO:0051654)2.99060999
131positive regulation of Rho protein signal transduction (GO:0035025)2.98873514
132homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.98135320
133neuron recognition (GO:0008038)2.98038840
134potassium ion transmembrane transport (GO:0071805)2.97821814
135cellular potassium ion transport (GO:0071804)2.97821814
136synaptic transmission, glutamatergic (GO:0035249)2.94796490
137negative regulation of blood circulation (GO:1903523)2.94572807
138potassium ion export (GO:0071435)2.92879593
139negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.91650495
140purinergic nucleotide receptor signaling pathway (GO:0035590)2.91598413
141response to histamine (GO:0034776)2.91029363
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90288456
143positive regulation of mast cell activation (GO:0033005)2.89622636
144positive regulation of potassium ion transport (GO:0043268)2.89346684
145eye photoreceptor cell development (GO:0042462)2.89098904
146establishment of vesicle localization (GO:0051650)2.88970671
147regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88294261
148regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88294261
149behavioral response to cocaine (GO:0048148)2.88144574
150negative regulation of microtubule polymerization (GO:0031115)2.87915212
151regulation of relaxation of muscle (GO:1901077)2.87747189
152regulation of vesicle fusion (GO:0031338)2.87310046
153positive regulation of synapse assembly (GO:0051965)2.87304023
154regulation of homotypic cell-cell adhesion (GO:0034110)2.87230241
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86279810
156negative regulation of dendrite development (GO:2000171)2.86105114
157synaptic transmission (GO:0007268)2.85851250
158fusion of sperm to egg plasma membrane (GO:0007342)2.85279306
159membrane depolarization (GO:0051899)2.84928783
160photoreceptor cell development (GO:0042461)2.84779970
161lipoxygenase pathway (GO:0019372)2.83019611
162positive regulation of myoblast differentiation (GO:0045663)2.82339795
163negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81208149
164regulation of female receptivity (GO:0045924)2.80202176
165negative regulation of catecholamine secretion (GO:0033604)2.79222813
166regulation of macrophage derived foam cell differentiation (GO:0010743)2.78823274
167myofibril assembly (GO:0030239)2.78093947
168positive regulation of systemic arterial blood pressure (GO:0003084)2.77822303
169negative regulation of muscle contraction (GO:0045932)2.76512767
170positive regulation of cardiac muscle hypertrophy (GO:0010613)2.76496903
171positive regulation of muscle hypertrophy (GO:0014742)2.76496903
172platelet activation (GO:0030168)2.74563545
173negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.72839716
174neutrophil activation (GO:0042119)2.71227041
175angiogenesis involved in wound healing (GO:0060055)2.69714993
176termination of G-protein coupled receptor signaling pathway (GO:0038032)2.65002086
177striated muscle contraction (GO:0006941)2.64949509
178regulation of norepinephrine secretion (GO:0014061)2.64399907
179purinergic receptor signaling pathway (GO:0035587)2.64115683
180cardiac muscle contraction (GO:0060048)2.62539641
181G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.60716149
182negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59617156
183actin filament-based movement (GO:0030048)2.59572364
184cardiac myofibril assembly (GO:0055003)2.56343682
185regulation of calcium ion transmembrane transport (GO:1903169)2.55860598
186regulation of calcium ion transmembrane transporter activity (GO:1901019)2.55860598
187beta-amyloid metabolic process (GO:0050435)2.55506219
188cardiac muscle hypertrophy (GO:0003300)2.53861538
189extracellular fibril organization (GO:0043206)2.52732140
190regulation of actin filament-based movement (GO:1903115)2.51689803
191termination of signal transduction (GO:0023021)2.50723147
192regulation of protein localization to cell surface (GO:2000008)2.48201890
193calcium-mediated signaling using intracellular calcium source (GO:0035584)2.47584401
194striated muscle hypertrophy (GO:0014897)2.45615079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.15045301
2EZH2_22144423_ChIP-Seq_EOC_Human3.52001593
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42128318
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.87923682
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81831476
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80340215
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72853497
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.65867856
9TAF15_26573619_Chip-Seq_HEK293_Human2.54690767
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54559715
11REST_21632747_ChIP-Seq_MESCs_Mouse2.54132179
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47615408
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43238976
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39428697
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39428697
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.34339645
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32900585
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32547490
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30111080
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29095997
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25377830
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22548562
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20987574
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19737642
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14513994
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.09102437
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09097028
28IGF1R_20145208_ChIP-Seq_DFB_Human2.08765841
29AR_21572438_ChIP-Seq_LNCaP_Human2.04841751
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04281208
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01467721
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01266483
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00770793
34DROSHA_22980978_ChIP-Seq_HELA_Human2.00084326
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99546261
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99368820
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95701017
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.92902967
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.85274588
40* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84814111
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.82358337
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.79160188
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77928892
44P300_19829295_ChIP-Seq_ESCs_Human1.77745897
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75925755
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.71126204
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.70326748
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68545418
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64957940
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.64286642
51SCL_19346495_ChIP-Seq_HPC-7_Human1.63032651
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62634503
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58456121
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58456121
55FUS_26573619_Chip-Seq_HEK293_Human1.56763951
56* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.56298182
57GATA1_19941826_ChIP-Seq_K562_Human1.52008157
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51118474
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.46878154
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46770298
61AR_25329375_ChIP-Seq_VCAP_Human1.45524318
62GATA2_19941826_ChIP-Seq_K562_Human1.45122495
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43045650
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.42780161
65HTT_18923047_ChIP-ChIP_STHdh_Human1.42304733
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39370929
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.36040878
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35723707
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.35622853
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35093588
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.34682181
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34146238
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34059392
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33562987
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33292595
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32843019
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.32359961
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31936654
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29899606
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29094077
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29031382
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28376203
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.24805992
84* STAT3_23295773_ChIP-Seq_U87_Human1.24779566
85ER_23166858_ChIP-Seq_MCF-7_Human1.24407011
86VDR_22108803_ChIP-Seq_LS180_Human1.23411694
87BCAT_22108803_ChIP-Seq_LS180_Human1.21364170
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20474604
89KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20031633
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19144052
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19144052
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.18765222
93AHR_22903824_ChIP-Seq_MCF-7_Human1.18512265
94* AR_19668381_ChIP-Seq_PC3_Human1.17929234
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17791253
96* TCF4_23295773_ChIP-Seq_U87_Human1.15704919
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14943036
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.14368967
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13626629
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.12720707
101GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12610107
102GATA1_22025678_ChIP-Seq_K562_Human1.12253881
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11925495
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.11366573
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10973953
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10446003
107TP53_16413492_ChIP-PET_HCT116_Human1.09420681
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.08335695
109EWS_26573619_Chip-Seq_HEK293_Human1.07300849
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.07285889
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.07235609
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07157872
113KDM2B_26808549_Chip-Seq_REH_Human1.07136065
114CBP_20019798_ChIP-Seq_JUKART_Human1.07085673
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07085673
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06713991
117RUNX2_22187159_ChIP-Seq_PCA_Human1.06509651
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06244457
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06146921
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05687397
121GF1_26923725_Chip-Seq_HPCs_Mouse1.05299908
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.05040670
123JUN_21703547_ChIP-Seq_K562_Human1.04985402
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03944150
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03557969
126LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02389797
127P53_22387025_ChIP-Seq_ESCs_Mouse1.02386713
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00637032
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00281255
130ZNF274_21170338_ChIP-Seq_K562_Hela1.00064969
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.99889355
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99741484
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.99401824
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.98337225
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95792470
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.95304521
137SOX9_26525672_Chip-Seq_HEART_Mouse0.95036912
138KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94604233
139* SALL4_22934838_ChIP-ChIP_CD34+_Human0.94137880
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93569598
141SPI1_23127762_ChIP-Seq_K562_Human0.93474319
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.93422278
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92105197
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91505364
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91449944
146NANOG_19829295_ChIP-Seq_ESCs_Human0.91449944
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.91431839
148CJUN_26792858_Chip-Seq_BT549_Human0.91310914
149CDX2_22108803_ChIP-Seq_LS180_Human0.91223882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.79311211
2MP0008004_abnormal_stomach_pH4.55481726
3MP0005551_abnormal_eye_electrophysiolog3.65330655
4MP0001968_abnormal_touch/_nociception3.44716506
5MP0003880_abnormal_central_pattern3.36437048
6MP0002735_abnormal_chemical_nociception3.23970323
7MP0001984_abnormal_olfaction3.16240357
8MP0004510_myositis3.14250195
9MP0004859_abnormal_synaptic_plasticity3.10869462
10MP0006276_abnormal_autonomic_nervous3.01820445
11MP0002736_abnormal_nociception_after2.92279145
12MP0003635_abnormal_synaptic_transmissio2.77985497
13MP0002734_abnormal_mechanical_nocicepti2.77777229
14MP0000465_gastrointestinal_hemorrhage2.72842684
15MP0003724_increased_susceptibility_to2.71561822
16MP0004270_analgesia2.68149323
17MP0006072_abnormal_retinal_apoptosis2.67881466
18MP0001502_abnormal_circadian_rhythm2.61878918
19MP0004130_abnormal_muscle_cell2.54096646
20MP0009046_muscle_twitch2.52127465
21MP0004484_altered_response_of2.44661979
22MP0002184_abnormal_innervation2.43550095
23MP0002972_abnormal_cardiac_muscle2.41161970
24MP0001486_abnormal_startle_reflex2.37915815
25MP0002063_abnormal_learning/memory/cond2.36403190
26MP0005620_abnormal_muscle_contractility2.34908097
27MP0002090_abnormal_vision2.32980250
28MP0002272_abnormal_nervous_system2.30987656
29MP0001188_hyperpigmentation2.28857138
30MP0002064_seizures2.24795230
31MP0002067_abnormal_sensory_capabilities2.23726018
32MP0009745_abnormal_behavioral_response2.20879647
33MP0000230_abnormal_systemic_arterial2.20644828
34MP0002572_abnormal_emotion/affect_behav2.07732671
35MP0005423_abnormal_somatic_nervous2.07655161
36MP0005253_abnormal_eye_physiology1.96558646
37MP0005670_abnormal_white_adipose1.95061804
38MP0002638_abnormal_pupillary_reflex1.92105303
39MP0002733_abnormal_thermal_nociception1.89657567
40MP0001970_abnormal_pain_threshold1.89644687
41MP0000778_abnormal_nervous_system1.85339464
42MP0006138_congestive_heart_failure1.84716843
43MP0001879_abnormal_lymphatic_vessel1.83909255
44MP0004233_abnormal_muscle_weight1.81913389
45MP0004858_abnormal_nervous_system1.79139208
46MP0003646_muscle_fatigue1.78918936
47MP0005167_abnormal_blood-brain_barrier1.78274273
48MP0000343_altered_response_to1.74131146
49MP0000749_muscle_degeneration1.72390960
50MP0001544_abnormal_cardiovascular_syste1.71037640
51MP0005385_cardiovascular_system_phenoty1.71037640
52MP0005083_abnormal_biliary_tract1.70716835
53MP0006292_abnormal_olfactory_placode1.68609513
54MP0003828_pulmonary_edema1.65047170
55MP0002752_abnormal_somatic_nervous1.61105681
56MP0002557_abnormal_social/conspecific_i1.61103683
57MP0002882_abnormal_neuron_morphology1.59906948
58MP0005410_abnormal_fertilization1.56791970
59MP0004782_abnormal_surfactant_physiolog1.55720559
60MP0005499_abnormal_olfactory_system1.54531696
61MP0005394_taste/olfaction_phenotype1.54531696
62MP0005195_abnormal_posterior_eye1.53708196
63MP0010386_abnormal_urinary_bladder1.53447446
64MP0001529_abnormal_vocalization1.51336463
65MP0000955_abnormal_spinal_cord1.50604508
66MP0003718_maternal_effect1.49901270
67MP0002106_abnormal_muscle_physiology1.47247932
68MP0003136_yellow_coat_color1.45896168
69MP0001986_abnormal_taste_sensitivity1.45395117
70MP0002751_abnormal_autonomic_nervous1.42056786
71MP0008789_abnormal_olfactory_epithelium1.42014598
72MP0003879_abnormal_hair_cell1.41730017
73MP0000631_abnormal_neuroendocrine_gland1.40234976
74MP0002229_neurodegeneration1.39934544
75MP0004811_abnormal_neuron_physiology1.39548953
76MP0002837_dystrophic_cardiac_calcinosis1.35597495
77MP0001501_abnormal_sleep_pattern1.35061976
78MP0004142_abnormal_muscle_tone1.35049496
79MP0001440_abnormal_grooming_behavior1.29882866
80MP0004924_abnormal_behavior1.27849902
81MP0005386_behavior/neurological_phenoty1.27849902
82MP0003183_abnormal_peptide_metabolism1.26461810
83MP0000751_myopathy1.26311990
84MP0008569_lethality_at_weaning1.25918682
85MP0004087_abnormal_muscle_fiber1.24008245
86MP0003566_abnormal_cell_adhesion1.23530418
87MP0009780_abnormal_chondrocyte_physiolo1.22948699
88MP0005085_abnormal_gallbladder_physiolo1.22646813
89MP0003122_maternal_imprinting1.19479658
90MP0005409_darkened_coat_color1.19470575
91MP0004215_abnormal_myocardial_fiber1.19102371
92MP0004145_abnormal_muscle_electrophysio1.18328481
93MP0003303_peritoneal_inflammation1.18255505
94MP0008260_abnormal_autophagy1.18137492
95MP0005646_abnormal_pituitary_gland1.17525906
96MP0002822_catalepsy1.17521677
97MP0004742_abnormal_vestibular_system1.16140554
98MP0005248_abnormal_Harderian_gland1.15753514
99MP0003638_abnormal_response/metabolism_1.15463139
100MP0001346_abnormal_lacrimal_gland1.14777599
101MP0002066_abnormal_motor_capabilities/c1.13743628
102MP0005645_abnormal_hypothalamus_physiol1.10862453
103MP0003787_abnormal_imprinting1.10255193
104MP0005369_muscle_phenotype1.09182132
105MP0005666_abnormal_adipose_tissue1.05678346
106MP0001963_abnormal_hearing_physiology1.04479382
107MP0009697_abnormal_copulation1.02538659
108MP0008775_abnormal_heart_ventricle1.01977200
109MP0010368_abnormal_lymphatic_system1.00741022
110MP0003634_abnormal_glial_cell1.00210587
111MP0000249_abnormal_blood_vessel0.99159043
112MP0010329_abnormal_lipoprotein_level0.98756829
113MP0005187_abnormal_penis_morphology0.97642747
114MP0002152_abnormal_brain_morphology0.97280023
115MP0002102_abnormal_ear_morphology0.94045905
116MP0005165_increased_susceptibility_to0.93514039
117MP0008874_decreased_physiological_sensi0.93498854
118MP0003011_delayed_dark_adaptation0.91372502
119MP0003137_abnormal_impulse_conducting0.91024113
120MP0005084_abnormal_gallbladder_morpholo0.90726946
121MP0003950_abnormal_plasma_membrane0.89923856
122MP0005330_cardiomyopathy0.88624763
123MP0002127_abnormal_cardiovascular_syste0.88597337
124MP0004085_abnormal_heartbeat0.88224239
125MP0000026_abnormal_inner_ear0.86520212
126MP0002069_abnormal_eating/drinking_beha0.85354985
127MP0005595_abnormal_vascular_smooth0.83695888
128MP0002132_abnormal_respiratory_system0.81778911
129MP0001765_abnormal_ion_homeostasis0.80524316
130MP0000534_abnormal_ureter_morphology0.80296469
131MP0003656_abnormal_erythrocyte_physiolo0.80262500
132MP0002909_abnormal_adrenal_gland0.80176725
133MP0004036_abnormal_muscle_relaxation0.79969720
134MP0010030_abnormal_orbit_morphology0.78023221
135MP0001324_abnormal_eye_pigmentation0.76342474
136MP0003329_amyloid_beta_deposits0.76055335
137MP0002128_abnormal_blood_circulation0.75706982
138MP0005535_abnormal_body_temperature0.75089360
139MP0010630_abnormal_cardiac_muscle0.75086946
140MP0000372_irregular_coat_pigmentation0.74963664
141MP0000759_abnormal_skeletal_muscle0.73310913
142MP0001905_abnormal_dopamine_level0.73090551
143MP0000747_muscle_weakness0.72335801
144MP0002971_abnormal_brown_adipose0.71394567
145MP0003633_abnormal_nervous_system0.71371991
146MP0002653_abnormal_ependyma_morphology0.71231717
147MP0001851_eye_inflammation0.71030766
148MP0005171_absent_coat_pigmentation0.70332213
149MP0000015_abnormal_ear_pigmentation0.70239287
150MP0004084_abnormal_cardiac_muscle0.69098368
151MP0005365_abnormal_bile_salt0.68776531
152MP0004885_abnormal_endolymph0.68602617
153MP0005391_vision/eye_phenotype0.65748372
154MP0001756_abnormal_urination0.65647958
155MP0002332_abnormal_exercise_endurance0.65598549
156MP0000750_abnormal_muscle_regeneration0.64628552
157MP0003091_abnormal_cell_migration0.64074055
158MP0002118_abnormal_lipid_homeostasis0.63719859
159MP0006036_abnormal_mitochondrial_physio0.63263211
160MP0008872_abnormal_physiological_respon0.63249547
161MP0009642_abnormal_blood_homeostasis0.62127483
162MP0001270_distended_abdomen0.61674958
163MP0001664_abnormal_digestion0.61431247
164MP0001663_abnormal_digestive_system0.61393892
165MP0001299_abnormal_eye_distance/0.61200501
166MP0003631_nervous_system_phenotype0.61144036
167MP0009763_increased_sensitivity_to0.60012229
168MP0000569_abnormal_digit_pigmentation0.59324343
169MP0003861_abnormal_nervous_system0.58962018

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.99186252
2Prolonged bleeding time (HP:0003010)8.59427610
3Increased mean platelet volume (HP:0011877)8.19865777
4Menorrhagia (HP:0000132)8.16737577
5Abnormal platelet volume (HP:0011876)7.57101995
6Petechiae (HP:0000967)6.87880730
7Purpura (HP:0000979)6.42095560
8Febrile seizures (HP:0002373)5.94750398
9Central scotoma (HP:0000603)5.64250084
10Epistaxis (HP:0000421)5.59403318
11Epileptic encephalopathy (HP:0200134)5.40628675
12Severe visual impairment (HP:0001141)5.28214247
13Abnormality of macular pigmentation (HP:0008002)5.16853918
14Gingival bleeding (HP:0000225)5.03748590
15Septo-optic dysplasia (HP:0100842)4.43806168
16Bundle branch block (HP:0011710)4.37879012
17Hyperlipoproteinemia (HP:0010980)4.35306254
18Abnormal platelet function (HP:0011869)4.16905877
19Impaired platelet aggregation (HP:0003540)4.16905877
20Focal motor seizures (HP:0011153)4.13014471
21Myokymia (HP:0002411)4.08361613
22Ulnar claw (HP:0001178)4.05396696
23Absence seizures (HP:0002121)4.04875120
24Muscle fiber inclusion bodies (HP:0100299)3.99361542
25Muscle fiber splitting (HP:0003555)3.88730383
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.88501143
27Progressive cerebellar ataxia (HP:0002073)3.85273441
28Nemaline bodies (HP:0003798)3.83841309
29Abnormal rod and cone electroretinograms (HP:0008323)3.81919306
30Spontaneous hematomas (HP:0007420)3.75165554
31Acanthocytosis (HP:0001927)3.57074569
32Scotoma (HP:0000575)3.53654262
33Dialeptic seizures (HP:0011146)3.52340157
34Action tremor (HP:0002345)3.50372015
35Atonic seizures (HP:0010819)3.45018695
36Poikilocytosis (HP:0004447)3.43026253
37Focal seizures (HP:0007359)3.39500258
38Hyporeflexia of lower limbs (HP:0002600)3.34471347
39Sudden death (HP:0001699)3.33735671
40Decreased central vision (HP:0007663)3.23025447
41Aplasia/Hypoplasia of the fovea (HP:0008060)3.22145361
42Hypoplasia of the fovea (HP:0007750)3.22145361
43Gait imbalance (HP:0002141)3.15296997
44Conjunctival telangiectasia (HP:0000524)3.11562074
45Ventricular fibrillation (HP:0001663)3.07014797
46Papillary thyroid carcinoma (HP:0002895)3.00745411
47Abnormality of the left ventricular outflow tract (HP:0011103)3.00079654
48Subaortic stenosis (HP:0001682)3.00079654
49Keratoconus (HP:0000563)2.99838007
50Increased corneal curvature (HP:0100692)2.99838007
51Dyschromatopsia (HP:0007641)2.95314772
52Exercise-induced myalgia (HP:0003738)2.95311280
53Visual hallucinations (HP:0002367)2.92892268
54Generalized tonic-clonic seizures (HP:0002069)2.82528656
55Insidious onset (HP:0003587)2.79252092
56Termporal pattern (HP:0011008)2.79252092
57Polyphagia (HP:0002591)2.79179127
58Congenital primary aphakia (HP:0007707)2.78107186
59Medial flaring of the eyebrow (HP:0010747)2.75221775
60Abnormal pupillary function (HP:0007686)2.74313918
61Type 1 muscle fiber predominance (HP:0003803)2.73255146
62Mutism (HP:0002300)2.72263191
63Exercise-induced muscle cramps (HP:0003710)2.70729030
64Muscle hypertrophy of the lower extremities (HP:0008968)2.70123404
65Abnormality of the fovea (HP:0000493)2.68189891
66Nephrogenic diabetes insipidus (HP:0009806)2.67470392
67Abnormality of the calf musculature (HP:0001430)2.65401339
68Ventricular tachycardia (HP:0004756)2.65200780
69Optic nerve hypoplasia (HP:0000609)2.64132364
70Abnormality of lateral ventricle (HP:0030047)2.62049444
71Calf muscle hypertrophy (HP:0008981)2.57629925
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.56951896
73Atrial fibrillation (HP:0005110)2.56777205
74Increased density of long bones (HP:0006392)2.55461572
75Abnormal auditory evoked potentials (HP:0006958)2.53974181
76Bruising susceptibility (HP:0000978)2.50299343
77Distal lower limb amyotrophy (HP:0008944)2.47586305
78Limb dystonia (HP:0002451)2.47382410
79Absent septum pellucidum (HP:0001331)2.45574665
80Paralysis (HP:0003470)2.45049250
81Heart block (HP:0012722)2.44739896
82Syncope (HP:0001279)2.44394222
83Drooling (HP:0002307)2.43460448
84Excessive salivation (HP:0003781)2.43460448
85Abnormal hair whorl (HP:0010721)2.41532698
86Primary atrial arrhythmia (HP:0001692)2.41274363
87Hemiparesis (HP:0001269)2.41051406
88Frequent falls (HP:0002359)2.40610164
89Rimmed vacuoles (HP:0003805)2.40505652
90Bony spicule pigmentary retinopathy (HP:0007737)2.34966644
91Abnormality of the common coagulation pathway (HP:0010990)2.34289695
92Cholecystitis (HP:0001082)2.33226575
93Abnormal gallbladder physiology (HP:0012438)2.33226575
94Genital tract atresia (HP:0001827)2.33050290
95Steppage gait (HP:0003376)2.31329352
96Distal lower limb muscle weakness (HP:0009053)2.29208501
97Supranuclear gaze palsy (HP:0000605)2.29160993
98Abnormal atrioventricular conduction (HP:0005150)2.28772946
99Fetal akinesia sequence (HP:0001989)2.27281443
100EEG with generalized epileptiform discharges (HP:0011198)2.27179919
101Supraventricular tachycardia (HP:0004755)2.26888631
102Epileptiform EEG discharges (HP:0011182)2.26843649
103Albinism (HP:0001022)2.26273346
104Vaginal atresia (HP:0000148)2.25130545
105Ankle clonus (HP:0011448)2.24648411
106Hypoplasia of the brainstem (HP:0002365)2.24355859
107Aplasia/Hypoplasia of the brainstem (HP:0007362)2.24355859
108Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.23926791
109Supraventricular arrhythmia (HP:0005115)2.22874737
110Retinal dysplasia (HP:0007973)2.21756326
111Lipoatrophy (HP:0100578)2.20234708
112Growth hormone deficiency (HP:0000824)2.17438883
113Generalized aminoaciduria (HP:0002909)2.17161917
114Abnormal eating behavior (HP:0100738)2.17050135
115EMG: myopathic abnormalities (HP:0003458)2.16081428
116Lower limb amyotrophy (HP:0007210)2.13784625
117Pheochromocytoma (HP:0002666)2.12338610
118Generalized hypopigmentation (HP:0007513)2.11909151
119Hypophosphatemic rickets (HP:0004912)2.11485489
120Failure to thrive in infancy (HP:0001531)2.11470569
121Poor coordination (HP:0002370)2.09067753
122Dysdiadochokinesis (HP:0002075)2.07311715
123Specific learning disability (HP:0001328)2.07153990
124Ventricular arrhythmia (HP:0004308)2.06749674
125Abnormality of skeletal muscle fiber size (HP:0012084)2.06694113
126Abnormality of the septum pellucidum (HP:0007375)2.06349679
127Hypothermia (HP:0002045)2.05570723
128Nausea (HP:0002018)2.05542311
129Aplasia/Hypoplasia of the macula (HP:0008059)2.05162214
130Thyroid-stimulating hormone excess (HP:0002925)2.05116407
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05097173
132Prolonged QT interval (HP:0001657)2.04911294
133Myoglobinuria (HP:0002913)2.04545388
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03777521
135Hypoventilation (HP:0002791)2.01560059
136Difficulty running (HP:0009046)2.00225159
137Abnormality of the lower motor neuron (HP:0002366)1.98763438
138Areflexia of lower limbs (HP:0002522)1.97812303
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97120244
140Dilated cardiomyopathy (HP:0001644)1.96932937
141Hyperventilation (HP:0002883)1.96918394
142Narrow nasal bridge (HP:0000446)1.96810365
143Depression (HP:0000716)1.96113099
144Distal arthrogryposis (HP:0005684)1.95928930
145Aplasia/Hypoplasia of the lens (HP:0008063)1.93806701
146Segmental peripheral demyelination/remyelination (HP:0003481)1.92984126
147Upper limb muscle weakness (HP:0003484)1.92983815
148Abnormality of the vocal cords (HP:0008777)1.92314369
149Tinnitus (HP:0000360)1.92120026
150Severe Myopia (HP:0011003)1.90351469
151Gaze-evoked nystagmus (HP:0000640)1.88503137
152Truncal ataxia (HP:0002078)1.88025595
153Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87692946
154EMG: neuropathic changes (HP:0003445)1.85258382
155Neck muscle weakness (HP:0000467)1.83936939
156Biliary tract neoplasm (HP:0100574)1.83886614
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.82707381
158Hammertoe (HP:0001765)1.82253851
159Absent speech (HP:0001344)1.81925943
160Amblyopia (HP:0000646)1.81627980
161Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81404461
162Increased variability in muscle fiber diameter (HP:0003557)1.81024845
163Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81024675
164Neuroendocrine neoplasm (HP:0100634)1.80980381
165Hypsarrhythmia (HP:0002521)1.80719424
166Asymmetric septal hypertrophy (HP:0001670)1.80694335
167Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80391707
168Genetic anticipation (HP:0003743)1.79049697
169Thyroid carcinoma (HP:0002890)1.76737901
170Urinary bladder sphincter dysfunction (HP:0002839)1.76668226
171Scanning speech (HP:0002168)1.76631302
172Congenital sensorineural hearing impairment (HP:0008527)1.75840842
173Difficulty walking (HP:0002355)1.72983263
174Esotropia (HP:0000565)1.72490211
175Polycythemia (HP:0001901)1.71811624
176Broad-based gait (HP:0002136)1.70769968
177Spastic gait (HP:0002064)1.69381518
178Astigmatism (HP:0000483)1.69127850
179Joint hemorrhage (HP:0005261)1.67918880
180Muscle fibrillation (HP:0010546)1.67894357
181Impaired proprioception (HP:0010831)1.67833796
182Xanthomatosis (HP:0000991)1.67310357
183Abnormality of salivation (HP:0100755)1.67072350
184Left ventricular hypertrophy (HP:0001712)1.66656453
185Gowers sign (HP:0003391)1.64088320
186Male infertility (HP:0003251)1.62229402
187Mitral stenosis (HP:0001718)1.61283755
188Tongue fasciculations (HP:0001308)1.61142648
189Abnormal EKG (HP:0003115)1.60776752
190Generalized muscle weakness (HP:0003324)1.58866675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.61281488
2MARK14.20482457
3OBSCN4.19588456
4MAP3K43.51710501
5MYLK3.44073768
6MINK13.05414601
7MAP2K72.96640560
8BMX2.94582565
9MST42.89052392
10NTRK32.80722981
11RIPK42.70167746
12PAK62.70143057
13PRPF4B2.38056727
14TEC2.30588946
15PTK2B2.27599510
16PHKG12.27436101
17PHKG22.27436101
18PIK3CG2.24909634
19MAPK132.14657035
20EIF2AK12.12244954
21MAP3K91.97593456
22NME11.85306726
23TAOK31.84943017
24AKT31.74797290
25SIK31.72234740
26NTRK21.72058694
27NEK11.63111985
28TTN1.62763204
29ARAF1.62138146
30DYRK1A1.51625547
31EPHA41.49752100
32MAP2K41.48201153
33MAPKAPK31.47273139
34SGK2231.42515029
35SGK4941.42515029
36BTK1.39832393
37CSF1R1.39191262
38CDK81.36902983
39TNIK1.36395980
40SGK21.34361257
41PLK21.33296839
42DAPK21.32795069
43LMTK21.27897937
44FGR1.26063625
45ACVR1B1.24954825
46LATS21.24784140
47STK241.24480501
48GRK51.23081928
49TNK21.19752606
50DMPK1.19323776
51MAP3K121.19045395
52SYK1.19045113
53MAPK121.16890096
54CDK51.16470109
55ILK1.16368222
56PRKCG1.13715819
57PKN21.11430366
58PINK11.08770734
59ERBB31.08379596
60EPHA31.05865659
61EPHB21.05521323
62STK381.04781173
63DYRK21.04113175
64ZAP701.03502399
65TAOK21.02151383
66KSR11.01909077
67PRKCE0.97682723
68CDK140.96474095
69INSRR0.95614480
70CAMK2A0.95477282
71MAP3K60.94829722
72STK30.93908780
73FER0.91933574
74CDK180.91073118
75MAP3K50.91001972
76UHMK10.89399906
77PRKD10.87940328
78NTRK10.85478909
79CAMK2D0.85291047
80YES10.84671367
81WNK30.83856354
82GRK60.83248543
83CDK150.82388433
84BCR0.79478779
85PKN10.77643958
86SIK20.76860673
87TRIM280.76289016
88FRK0.75946876
89HCK0.75695841
90PNCK0.72552491
91CSNK1G20.72382073
92IRAK20.71647464
93SGK30.71627944
94CDK11A0.71529010
95PAK30.69698733
96PDK10.68760374
97IRAK10.68496538
98PIM20.67965056
99STK390.67007052
100CAMKK20.66545914
101PRKACG0.66537226
102BMPR20.63537114
103CDK30.63209906
104TIE10.63188604
105FES0.61949944
106RPS6KA20.61705460
107MAP2K30.59752891
108CAMK2B0.59008422
109ADRBK20.58781005
110PAK10.58351847
111ADRBK10.58334835
112BRAF0.56994652
113TAOK10.56708733
114PRKG10.56634843
115ERBB20.56468862
116EPHB10.55552896
117PRKACA0.55480567
118PRKAA10.54494637
119RAF10.53336296
120PRKCZ0.53101632
121MET0.52599256
122BMPR1B0.52562274
123MAP4K20.52410583
124CAMK10.51598260
125MARK20.51398374
126KSR20.51378389
127DAPK10.51292776
128GRK70.51275445
129LIMK10.50814459
130MAP2K10.50670412
131CAMK2G0.50252006
132CCNB10.50246599
133DDR20.50064567
134PDPK10.49935387
135PIK3CA0.49415615
136PRKCB0.49046563
137NEK90.47992048
138ROCK20.46547910
139STK38L0.46505469
140MARK30.46487669
141MAPK100.46370568
142DYRK1B0.45015070
143SGK10.44807489
144OXSR10.43450177
145MAP3K70.43091607
146CAMKK10.42826845
147RPS6KA30.42776096
148WNK10.42275121
149PRKCA0.42253796
150ROCK10.42120812
151LYN0.41941408
152MAPK90.41488280
153NEK60.40525187
154CSNK1G30.39183326
155RET0.38435365
156PLK30.37983314
157PRKACB0.36786723

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.84844262
2Synaptic vesicle cycle_Homo sapiens_hsa047214.03721222
3Platelet activation_Homo sapiens_hsa046113.87029476
4GABAergic synapse_Homo sapiens_hsa047273.38572982
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.26603023
6Morphine addiction_Homo sapiens_hsa050323.07306155
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.63088414
8Olfactory transduction_Homo sapiens_hsa047402.50766348
9Circadian entrainment_Homo sapiens_hsa047132.47568680
10Insulin secretion_Homo sapiens_hsa049112.07047800
11Collecting duct acid secretion_Homo sapiens_hsa049662.06818475
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03864995
13Serotonergic synapse_Homo sapiens_hsa047262.03315839
14Phototransduction_Homo sapiens_hsa047442.00878559
15Taste transduction_Homo sapiens_hsa047422.00853703
16Glutamatergic synapse_Homo sapiens_hsa047241.99368425
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.90733104
18ECM-receptor interaction_Homo sapiens_hsa045121.90581500
19Cholinergic synapse_Homo sapiens_hsa047251.84933232
20Dopaminergic synapse_Homo sapiens_hsa047281.84530456
21Salivary secretion_Homo sapiens_hsa049701.81376371
22Nitrogen metabolism_Homo sapiens_hsa009101.78216903
23Renin secretion_Homo sapiens_hsa049241.75077888
24Circadian rhythm_Homo sapiens_hsa047101.71418135
25Cardiac muscle contraction_Homo sapiens_hsa042601.69803688
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62757205
27Oxytocin signaling pathway_Homo sapiens_hsa049211.45564803
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42200111
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40403655
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39866490
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39718936
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36523193
33Calcium signaling pathway_Homo sapiens_hsa040201.33425589
34Arachidonic acid metabolism_Homo sapiens_hsa005901.30498592
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28709921
36Amphetamine addiction_Homo sapiens_hsa050311.23961351
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23550444
38Long-term depression_Homo sapiens_hsa047301.22019988
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21725712
40Chemokine signaling pathway_Homo sapiens_hsa040621.20588328
41Axon guidance_Homo sapiens_hsa043601.20077301
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19858572
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18096529
44Gap junction_Homo sapiens_hsa045401.17519985
45Vibrio cholerae infection_Homo sapiens_hsa051101.15586113
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14719427
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13376789
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11522832
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10188544
50Focal adhesion_Homo sapiens_hsa045101.08899656
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08577692
52Renin-angiotensin system_Homo sapiens_hsa046141.08327516
53Long-term potentiation_Homo sapiens_hsa047201.08272452
54Starch and sucrose metabolism_Homo sapiens_hsa005001.07570021
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06643978
56Cocaine addiction_Homo sapiens_hsa050301.04363686
57Dilated cardiomyopathy_Homo sapiens_hsa054141.03138734
58Fructose and mannose metabolism_Homo sapiens_hsa000511.02267514
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01180683
60Glycerolipid metabolism_Homo sapiens_hsa005610.99435217
61PPAR signaling pathway_Homo sapiens_hsa033200.96896018
62cAMP signaling pathway_Homo sapiens_hsa040240.94466367
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93775017
64Adherens junction_Homo sapiens_hsa045200.89487253
65GnRH signaling pathway_Homo sapiens_hsa049120.88907103
66Linoleic acid metabolism_Homo sapiens_hsa005910.87340540
67Gastric acid secretion_Homo sapiens_hsa049710.87101416
68Arginine and proline metabolism_Homo sapiens_hsa003300.86461318
69Oxidative phosphorylation_Homo sapiens_hsa001900.84542067
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.84184988
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.83407731
72Bile secretion_Homo sapiens_hsa049760.83239119
73Type II diabetes mellitus_Homo sapiens_hsa049300.82605332
74Hematopoietic cell lineage_Homo sapiens_hsa046400.82103670
75Mineral absorption_Homo sapiens_hsa049780.81732265
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80348185
77Ovarian steroidogenesis_Homo sapiens_hsa049130.79939833
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77939133
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77798147
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77234920
81beta-Alanine metabolism_Homo sapiens_hsa004100.76350821
82ErbB signaling pathway_Homo sapiens_hsa040120.75522255
83Fat digestion and absorption_Homo sapiens_hsa049750.72798115
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67697582
85Alzheimers disease_Homo sapiens_hsa050100.66811482
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.65883520
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65811782
88MAPK signaling pathway_Homo sapiens_hsa040100.65085536
89Alcoholism_Homo sapiens_hsa050340.62967176
90Sulfur metabolism_Homo sapiens_hsa009200.62572000
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.62422766
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61332119
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60297412
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60277730
95Tight junction_Homo sapiens_hsa045300.59377493
96ABC transporters_Homo sapiens_hsa020100.58570191
97Parkinsons disease_Homo sapiens_hsa050120.57744652
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56298645
99Phagosome_Homo sapiens_hsa041450.55163101
100Rheumatoid arthritis_Homo sapiens_hsa053230.54329707
101Ras signaling pathway_Homo sapiens_hsa040140.53549488
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52857485
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52795857
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.50977674
105Melanoma_Homo sapiens_hsa052180.50457743
106Pancreatic secretion_Homo sapiens_hsa049720.49590425
107Amoebiasis_Homo sapiens_hsa051460.48846635
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.48787280
109Pancreatic cancer_Homo sapiens_hsa052120.47925836
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46117346
111Estrogen signaling pathway_Homo sapiens_hsa049150.46080284
112Fatty acid biosynthesis_Homo sapiens_hsa000610.45721664
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45332379
114Endometrial cancer_Homo sapiens_hsa052130.45330191
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43674926
116Galactose metabolism_Homo sapiens_hsa000520.42231138
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41401732
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41099953
119Regulation of autophagy_Homo sapiens_hsa041400.40860370
120Shigellosis_Homo sapiens_hsa051310.40719178
121Choline metabolism in cancer_Homo sapiens_hsa052310.39305311
122Melanogenesis_Homo sapiens_hsa049160.39282497
123Colorectal cancer_Homo sapiens_hsa052100.38702307
124Renal cell carcinoma_Homo sapiens_hsa052110.37334108
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36941980
126Glioma_Homo sapiens_hsa052140.34272166
127Ether lipid metabolism_Homo sapiens_hsa005650.33236904
128mTOR signaling pathway_Homo sapiens_hsa041500.32124320
129Inositol phosphate metabolism_Homo sapiens_hsa005620.31930571
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.31184259
131Oocyte meiosis_Homo sapiens_hsa041140.31068437
132Dorso-ventral axis formation_Homo sapiens_hsa043200.30869503
133Thyroid hormone synthesis_Homo sapiens_hsa049180.29517523
134Huntingtons disease_Homo sapiens_hsa050160.27832673
135Rap1 signaling pathway_Homo sapiens_hsa040150.27455704
136Insulin signaling pathway_Homo sapiens_hsa049100.27088688
137Wnt signaling pathway_Homo sapiens_hsa043100.25335217
138Endocytosis_Homo sapiens_hsa041440.25231820
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19413809
140Glucagon signaling pathway_Homo sapiens_hsa049220.19017231
141Hedgehog signaling pathway_Homo sapiens_hsa043400.18241561

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