FRMD4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89088811
2L-phenylalanine catabolic process (GO:0006559)4.89088811
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36523015
4L-phenylalanine metabolic process (GO:0006558)4.36523015
5aromatic amino acid family catabolic process (GO:0009074)4.30420660
6endothelium development (GO:0003158)4.16009106
7tryptophan catabolic process (GO:0006569)3.88542297
8indole-containing compound catabolic process (GO:0042436)3.88542297
9indolalkylamine catabolic process (GO:0046218)3.88542297
10tryptophan metabolic process (GO:0006568)3.83888196
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.76740974
12protein carboxylation (GO:0018214)3.71294903
13peptidyl-glutamic acid carboxylation (GO:0017187)3.71294903
14complement activation, alternative pathway (GO:0006957)3.65306435
15neural tube formation (GO:0001841)3.60653984
16phospholipid efflux (GO:0033700)3.58185858
17alpha-linolenic acid metabolic process (GO:0036109)3.56823014
18phospholipid homeostasis (GO:0055091)3.53520821
19bile acid biosynthetic process (GO:0006699)3.47022480
20high-density lipoprotein particle remodeling (GO:0034375)3.42420302
21thrombin receptor signaling pathway (GO:0070493)3.41300678
22negative regulation of lipase activity (GO:0060192)3.39458480
23cholesterol efflux (GO:0033344)3.39162991
24fatty acid elongation (GO:0030497)3.38790890
25positive regulation by symbiont of host defense response (GO:0052509)3.38149588
26modulation by symbiont of host defense response (GO:0052031)3.38149588
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38149588
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38149588
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.38149588
30modulation by symbiont of host immune response (GO:0052553)3.38149588
31regulation of protein activation cascade (GO:2000257)3.37078319
32kynurenine metabolic process (GO:0070189)3.35769335
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34165557
34reverse cholesterol transport (GO:0043691)3.34096598
35microglial cell activation (GO:0001774)3.33277191
36urea cycle (GO:0000050)3.31783528
37urea metabolic process (GO:0019627)3.31783528
38regulation of rhodopsin mediated signaling pathway (GO:0022400)3.31278606
39negative regulation of fibrinolysis (GO:0051918)3.30846668
40bile acid metabolic process (GO:0008206)3.27903854
41glyoxylate metabolic process (GO:0046487)3.25147145
42rhodopsin mediated signaling pathway (GO:0016056)3.23530329
43negative regulation of protein localization to cell surface (GO:2000009)3.20273268
44plasma lipoprotein particle clearance (GO:0034381)3.20017793
45regulation of complement activation (GO:0030449)3.19516118
46regulation of fibrinolysis (GO:0051917)3.15943012
47regulation of interferon-beta biosynthetic process (GO:0045357)3.11507186
48regulation of sarcomere organization (GO:0060297)3.08986272
49regulation of cholesterol esterification (GO:0010872)3.07970133
50bile acid and bile salt transport (GO:0015721)3.06194236
51plasma lipoprotein particle assembly (GO:0034377)3.05263392
52tyrosine metabolic process (GO:0006570)3.04948447
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04712903
54nitrogen cycle metabolic process (GO:0071941)3.00398362
55indolalkylamine metabolic process (GO:0006586)2.99173570
56aromatic amino acid family metabolic process (GO:0009072)2.93905889
57cellular biogenic amine catabolic process (GO:0042402)2.92378967
58amine catabolic process (GO:0009310)2.92378967
59photoreceptor cell maintenance (GO:0045494)2.89908224
60positive regulation of endothelial cell differentiation (GO:0045603)2.89762162
61fucose catabolic process (GO:0019317)2.88264640
62L-fucose metabolic process (GO:0042354)2.88264640
63L-fucose catabolic process (GO:0042355)2.88264640
64protein-lipid complex assembly (GO:0065005)2.88235356
65detection of light stimulus involved in visual perception (GO:0050908)2.84989496
66detection of light stimulus involved in sensory perception (GO:0050962)2.84989496
67positive regulation of vasculogenesis (GO:2001214)2.83723996
68regulation of triglyceride catabolic process (GO:0010896)2.82505700
69triglyceride homeostasis (GO:0070328)2.82053567
70acylglycerol homeostasis (GO:0055090)2.82053567
71limb bud formation (GO:0060174)2.80486530
72very long-chain fatty acid metabolic process (GO:0000038)2.78232557
73long-chain fatty acid biosynthetic process (GO:0042759)2.77543882
74platelet dense granule organization (GO:0060155)2.77446181
75homocysteine metabolic process (GO:0050667)2.76753920
76regulation of pigment cell differentiation (GO:0050932)2.74428855
77plasma lipoprotein particle remodeling (GO:0034369)2.74304962
78protein-lipid complex remodeling (GO:0034368)2.74304962
79macromolecular complex remodeling (GO:0034367)2.74304962
80interkinetic nuclear migration (GO:0022027)2.72945816
81cysteine metabolic process (GO:0006534)2.72712198
82cellular glucuronidation (GO:0052695)2.71715157
83phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70768431
84negative regulation of cholesterol transport (GO:0032375)2.70233321
85negative regulation of sterol transport (GO:0032372)2.70233321
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67084308
87macrophage activation involved in immune response (GO:0002281)2.66491202
88very-low-density lipoprotein particle assembly (GO:0034379)2.66130882
89regulation of endothelial cell differentiation (GO:0045601)2.65167251
90complement activation (GO:0006956)2.65064979
91eye photoreceptor cell differentiation (GO:0001754)2.63981171
92photoreceptor cell differentiation (GO:0046530)2.63981171
93negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.63462374
94regulation of vasculogenesis (GO:2001212)2.63291752
95positive regulation of mast cell activation (GO:0033005)2.62374243
96positive regulation of triglyceride lipase activity (GO:0061365)2.59945344
97positive regulation of lipoprotein lipase activity (GO:0051006)2.59945344
98cholesterol homeostasis (GO:0042632)2.59756687
99complement activation, classical pathway (GO:0006958)2.58877742
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.58069372
101phototransduction, visible light (GO:0007603)2.57354177
102regulation of bile acid biosynthetic process (GO:0070857)2.56683763
103positive regulation of cellular amide metabolic process (GO:0034250)2.56076636
104fibrinolysis (GO:0042730)2.55605050
105linoleic acid metabolic process (GO:0043651)2.54499634
106sterol homeostasis (GO:0055092)2.54434384
107axon ensheathment in central nervous system (GO:0032291)2.54229756
108central nervous system myelination (GO:0022010)2.54229756
109protein activation cascade (GO:0072376)2.53548579
110positive regulation of developmental pigmentation (GO:0048087)2.53255540
111adaptation of signaling pathway (GO:0023058)2.52607423
112tyrosine phosphorylation of STAT protein (GO:0007260)2.52597401
113neutrophil activation involved in immune response (GO:0002283)2.52046672
114low-density lipoprotein particle remodeling (GO:0034374)2.51900867
115nerve growth factor signaling pathway (GO:0038180)2.51810919
116detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51696536
117sulfur amino acid catabolic process (GO:0000098)2.50650740
118import into cell (GO:0098657)2.50538420
119glucuronate metabolic process (GO:0019585)2.50104540
120uronic acid metabolic process (GO:0006063)2.50104540
121phototransduction (GO:0007602)2.49369934
122auditory receptor cell differentiation (GO:0042491)2.49209417
123positive regulation of phosphatase activity (GO:0010922)2.48880646
124lipoprotein metabolic process (GO:0042157)2.48467962
125cyclic nucleotide catabolic process (GO:0009214)2.47904867
126response to lipoprotein particle (GO:0055094)2.47637136
127positive regulation of glycolytic process (GO:0045821)2.47526457
128positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47192338
129plasma lipoprotein particle organization (GO:0071827)2.46768651
130DNA deamination (GO:0045006)2.44823583
131protein neddylation (GO:0045116)2.44294796
132angiogenesis involved in wound healing (GO:0060055)2.43116470
133heme transport (GO:0015886)2.42705059
134detection of visible light (GO:0009584)2.42503528
135retinal cone cell development (GO:0046549)2.42142737
136regulation of phospholipase A2 activity (GO:0032429)2.42003534
137regulation of MHC class II biosynthetic process (GO:0045346)2.40078202
138regulation of germinal center formation (GO:0002634)2.40057697
139multicellular organism reproduction (GO:0032504)2.39298909
140cAMP catabolic process (GO:0006198)2.38887150
141endoderm formation (GO:0001706)2.38162537
142leukocyte migration involved in inflammatory response (GO:0002523)2.34899397
143regulation of platelet activation (GO:0010543)2.32505138
144negative regulation of systemic arterial blood pressure (GO:0003085)2.31674827
145pyrimidine nucleobase catabolic process (GO:0006208)2.31375261
146cardiac chamber formation (GO:0003207)2.30008868
147cellular extravasation (GO:0045123)2.29063773
148cellular response to ethanol (GO:0071361)2.24699130
149regulation of meiosis I (GO:0060631)2.23022456
150cardiac ventricle formation (GO:0003211)2.22981850
151establishment of protein localization to Golgi (GO:0072600)2.20658801
152regulation of neuron projection regeneration (GO:0070570)2.20292842
153regulation of axon regeneration (GO:0048679)2.20292842
154neutrophil activation (GO:0042119)2.19519551
155positive regulation of cardiac muscle hypertrophy (GO:0010613)2.17224369
156positive regulation of muscle hypertrophy (GO:0014742)2.17224369
157negative regulation of mast cell activation (GO:0033004)2.16633368
158protein K11-linked deubiquitination (GO:0035871)2.16544248
159somite development (GO:0061053)2.16123389
160behavioral response to nicotine (GO:0035095)2.14712164
161superoxide anion generation (GO:0042554)2.14305578
162glial cell proliferation (GO:0014009)2.14059030
163thyroid hormone generation (GO:0006590)2.13409834
164activated T cell proliferation (GO:0050798)2.12672963
165sphingoid metabolic process (GO:0046519)2.11452586
166keratinization (GO:0031424)2.11435548
167negative regulation of neurotransmitter transport (GO:0051589)2.10741294
168positive regulation of cAMP-mediated signaling (GO:0043950)2.09899110
169thyroid hormone metabolic process (GO:0042403)2.09876267
170glycosphingolipid biosynthetic process (GO:0006688)2.09046391
171piRNA metabolic process (GO:0034587)2.08790566
172negative regulation of thymocyte apoptotic process (GO:0070244)2.08716811
173retrograde transport, vesicle recycling within Golgi (GO:0000301)2.08352699
174positive regulation of protein homodimerization activity (GO:0090073)2.08113263
175positive regulation of steroid hormone secretion (GO:2000833)2.07440628
176positive regulation of mast cell activation involved in immune response (GO:0033008)2.07027394
177positive regulation of mast cell degranulation (GO:0043306)2.07027394
178Rap protein signal transduction (GO:0032486)2.05708359
179phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.02910582
180negative regulation of platelet activation (GO:0010544)2.02709057
181positive regulation of toll-like receptor signaling pathway (GO:0034123)2.02708462
182cilium or flagellum-dependent cell motility (GO:0001539)2.02664122
183regulation of mast cell activation (GO:0033003)2.02517684
184cerebral cortex radially oriented cell migration (GO:0021799)2.02221576
185regulation of hippo signaling (GO:0035330)2.01303841
186dopamine transport (GO:0015872)2.00765601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67750537
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.73124582
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.55908684
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07931415
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.99043757
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81628406
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53781269
8EZH2_22144423_ChIP-Seq_EOC_Human2.51318912
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.47850409
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39122132
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34327101
12VDR_22108803_ChIP-Seq_LS180_Human2.24781082
13TAF15_26573619_Chip-Seq_HEK293_Human2.12454617
14ZNF274_21170338_ChIP-Seq_K562_Hela2.11006519
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.08780519
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87221085
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.84452097
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83632168
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82177353
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80813942
21* GATA2_21666600_ChIP-Seq_HMVEC_Human1.77536384
22SMAD4_21799915_ChIP-Seq_A2780_Human1.77083641
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73198601
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.70244355
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69534299
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68515267
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64974747
28GBX2_23144817_ChIP-Seq_PC3_Human1.64872345
29IGF1R_20145208_ChIP-Seq_DFB_Human1.64487293
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.62951642
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.62039167
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61604674
33BCAT_22108803_ChIP-Seq_LS180_Human1.61279231
34* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57130632
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.55499199
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.55324296
37EWS_26573619_Chip-Seq_HEK293_Human1.53613115
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52160143
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52160143
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51662644
41FUS_26573619_Chip-Seq_HEK293_Human1.50896882
42AR_25329375_ChIP-Seq_VCAP_Human1.50755941
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.49277999
44ER_23166858_ChIP-Seq_MCF-7_Human1.48747289
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.47882915
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47336462
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.46145145
48VDR_24787735_ChIP-Seq_THP-1_Human1.43847629
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42781819
50* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42514547
51TCF4_23295773_ChIP-Seq_U87_Human1.41230449
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40735694
53AHR_22903824_ChIP-Seq_MCF-7_Human1.40245250
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.37865599
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36269146
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.36054917
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33200575
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31533527
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31037273
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30685165
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30204702
62CBP_20019798_ChIP-Seq_JUKART_Human1.29515514
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29515514
64* TCF4_22108803_ChIP-Seq_LS180_Human1.28435593
65RUNX_20019798_ChIP-Seq_JUKART_Human1.28127774
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25674629
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.25218174
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24676347
69P53_22387025_ChIP-Seq_ESCs_Mouse1.23934759
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23671837
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.23019491
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22521911
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21809138
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.21466141
75AR_21572438_ChIP-Seq_LNCaP_Human1.21034464
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.20746494
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20647747
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19138876
79DROSHA_22980978_ChIP-Seq_HELA_Human1.18262858
80GATA1_22025678_ChIP-Seq_K562_Human1.18257468
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.18050256
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17472212
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.17354051
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.16963409
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15577568
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14662620
87* SOX2_19829295_ChIP-Seq_ESCs_Human1.13658077
88* NANOG_19829295_ChIP-Seq_ESCs_Human1.13658077
89RUNX2_22187159_ChIP-Seq_PCA_Human1.13448138
90* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13128854
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12417127
92CDX2_22108803_ChIP-Seq_LS180_Human1.11879886
93* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11479239
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11334875
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.11311961
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11193325
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10917431
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.10890335
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10511479
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08771227
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.08536265
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08014167
103* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07831128
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07665203
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.05879568
106SCL_19346495_ChIP-Seq_HPC-7_Human1.04942078
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03504807
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.03311548
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.02329072
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02170594
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.01999439
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.00580207
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00185635
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00185635
115P300_18555785_Chip-Seq_ESCs_Mouse0.99155682
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98775800
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97339696
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97134452
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.96897277
120* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95870809
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93381574
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93124780
123CJUN_26792858_Chip-Seq_BT549_Human0.92500265
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92218058
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.91018242
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.90644916
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90358999
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90347103
129* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88185462
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86880752
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85361482
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84617836
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.84268285
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84215749
135* SOX2_20726797_ChIP-Seq_SW620_Human0.82855328
136GATA1_19941826_ChIP-Seq_K562_Human0.82253536
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.81012580
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80272958
139PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79817488
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.79021569
141CLOCK_20551151_ChIP-Seq_293T_Human0.78573551
142* TP63_23658742_ChIP-Seq_EP156T_Human0.78017083
143GATA2_19941826_ChIP-Seq_K562_Human0.78014749
144TP53_16413492_ChIP-PET_HCT116_Human0.77967697
145* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77964956
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77633999
147GATA4_25053715_ChIP-Seq_YYC3_Human0.77300910
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.77023605
149* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76754262
150HTT_18923047_ChIP-ChIP_STHdh_Human0.75631311
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75097702
152PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74893359
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74726504
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74481161
155* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74269967
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73444881
157P300_19829295_ChIP-Seq_ESCs_Human0.72440894
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.72264558
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.70883081
160TBL1_22424771_ChIP-Seq_293T_Human0.70652224
161STAT3_23295773_ChIP-Seq_U87_Human0.70020637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.04862898
2MP0005360_urolithiasis4.46149053
3MP0003011_delayed_dark_adaptation4.31945594
4MP0005365_abnormal_bile_salt4.22096014
5MP0005085_abnormal_gallbladder_physiolo4.06653603
6MP0003252_abnormal_bile_duct3.45118108
7MP0009840_abnormal_foam_cell3.31188762
8MP0008875_abnormal_xenobiotic_pharmacok3.26657050
9MP0005551_abnormal_eye_electrophysiolog3.14616414
10MP0003191_abnormal_cellular_cholesterol3.02774001
11MP0005058_abnormal_lysosome_morphology2.92544021
12MP0002837_dystrophic_cardiac_calcinosis2.45274475
13MP0003690_abnormal_glial_cell2.40822601
14MP0004019_abnormal_vitamin_homeostasis2.24784460
15MP0010329_abnormal_lipoprotein_level2.24758661
16MP0008004_abnormal_stomach_pH2.20580936
17MP0002138_abnormal_hepatobiliary_system2.16974663
18MP0003646_muscle_fatigue2.16694899
19MP0003828_pulmonary_edema2.11002695
20MP0004084_abnormal_cardiac_muscle2.07906066
21MP0005083_abnormal_biliary_tract2.07707585
22MP0005451_abnormal_body_composition1.99361058
23MP0010368_abnormal_lymphatic_system1.90155991
24MP0005253_abnormal_eye_physiology1.89653821
25MP0003950_abnormal_plasma_membrane1.85015550
26MP0002254_reproductive_system_inflammat1.83415992
27MP0004215_abnormal_myocardial_fiber1.79139544
28MP0001666_abnormal_nutrient_absorption1.76944472
29MP0005084_abnormal_gallbladder_morpholo1.69049981
30MP0008775_abnormal_heart_ventricle1.60691598
31MP0001501_abnormal_sleep_pattern1.59981446
32MP0003300_gastrointestinal_ulcer1.59848170
33MP0005174_abnormal_tail_pigmentation1.59277704
34MP0005646_abnormal_pituitary_gland1.54445921
35MP0000609_abnormal_liver_physiology1.54047204
36MP0006082_CNS_inflammation1.53615930
37MP0000569_abnormal_digit_pigmentation1.53564178
38MP0003172_abnormal_lysosome_physiology1.53488352
39MP0002118_abnormal_lipid_homeostasis1.52771383
40MP0005332_abnormal_amino_acid1.51825605
41MP0003303_peritoneal_inflammation1.50311484
42MP0003045_fibrosis1.50106950
43MP0000383_abnormal_hair_follicle1.48674122
44MP0003195_calcinosis1.48248635
45MP0002090_abnormal_vision1.47491374
46MP0003806_abnormal_nucleotide_metabolis1.45098262
47MP0001324_abnormal_eye_pigmentation1.44860424
48MP0002148_abnormal_hypersensitivity_rea1.44729637
49MP0005195_abnormal_posterior_eye1.44282911
50MP0008877_abnormal_DNA_methylation1.44185431
51MP0000604_amyloidosis1.44107510
52MP0000920_abnormal_myelination1.41542433
53MP0002653_abnormal_ependyma_morphology1.36390332
54MP0002928_abnormal_bile_duct1.34536194
55MP0001764_abnormal_homeostasis1.34424275
56MP0000015_abnormal_ear_pigmentation1.32753372
57MP0000230_abnormal_systemic_arterial1.30570647
58MP0008789_abnormal_olfactory_epithelium1.29826469
59MP0004043_abnormal_pH_regulation1.28061667
60MP0004484_altered_response_of1.27128728
61MP0005670_abnormal_white_adipose1.26576406
62MP0010678_abnormal_skin_adnexa1.25842992
63MP0001486_abnormal_startle_reflex1.25546719
64MP0002419_abnormal_innate_immunity1.21919939
65MP0006054_spinal_hemorrhage1.17367206
66MP0002102_abnormal_ear_morphology1.17238800
67MP0001968_abnormal_touch/_nociception1.17047606
68MP0003787_abnormal_imprinting1.16208347
69MP0009764_decreased_sensitivity_to1.14539003
70MP0005464_abnormal_platelet_physiology1.13335532
71MP0002234_abnormal_pharynx_morphology1.12762563
72MP0008872_abnormal_physiological_respon1.09220095
73MP0009785_altered_susceptibility_to1.08908223
74MP0002229_neurodegeneration1.08398626
75MP0004381_abnormal_hair_follicle1.08228582
76MP0000465_gastrointestinal_hemorrhage1.07209904
77MP0000372_irregular_coat_pigmentation1.07060784
78MP0002095_abnormal_skin_pigmentation1.07032717
79MP0005410_abnormal_fertilization1.05212599
80MP0002736_abnormal_nociception_after1.05022646
81MP0005391_vision/eye_phenotype1.04546153
82MP0001851_eye_inflammation1.04368963
83MP0005075_abnormal_melanosome_morpholog1.02642651
84MP0005171_absent_coat_pigmentation1.02559041
85MP0005167_abnormal_blood-brain_barrier1.01659681
86MP0004085_abnormal_heartbeat1.00629316
87MP0005584_abnormal_enzyme/coenzyme_acti1.00290583
88MP0005408_hypopigmentation1.00251323
89MP0003724_increased_susceptibility_to0.99821341
90MP0001485_abnormal_pinna_reflex0.98939928
91MP0005319_abnormal_enzyme/_coenzyme0.98379745
92MP0003868_abnormal_feces_composition0.97946421
93MP0009643_abnormal_urine_homeostasis0.97091753
94MP0003075_altered_response_to0.96679498
95MP0009697_abnormal_copulation0.96671180
96MP0008469_abnormal_protein_level0.96219431
97MP0000343_altered_response_to0.93889927
98MP0003436_decreased_susceptibility_to0.93865534
99MP0004036_abnormal_muscle_relaxation0.93510812
100MP0004142_abnormal_muscle_tone0.93391109
101MP0004782_abnormal_surfactant_physiolog0.92807885
102MP0001835_abnormal_antigen_presentation0.92280305
103MP0002272_abnormal_nervous_system0.91295178
104MP0005000_abnormal_immune_tolerance0.89900932
105MP0005595_abnormal_vascular_smooth0.89515810
106MP0002638_abnormal_pupillary_reflex0.88547006
107MP0002876_abnormal_thyroid_physiology0.87911977
108MP0006072_abnormal_retinal_apoptosis0.87518349
109MP0002168_other_aberrant_phenotype0.86744669
110MP0001879_abnormal_lymphatic_vessel0.86719284
111MP0004885_abnormal_endolymph0.86648032
112MP0000647_abnormal_sebaceous_gland0.84985453
113MP0000767_abnormal_smooth_muscle0.84357023
114MP0002723_abnormal_immune_serum0.84206750
115MP0004742_abnormal_vestibular_system0.83901978
116MP0001800_abnormal_humoral_immune0.83099470
117MP0009763_increased_sensitivity_to0.81082099
118MP0005394_taste/olfaction_phenotype0.80808205
119MP0005499_abnormal_olfactory_system0.80808205
120MP0004510_myositis0.80720664
121MP0003136_yellow_coat_color0.79906340
122MP0002733_abnormal_thermal_nociception0.79863676
123MP0005387_immune_system_phenotype0.79232767
124MP0001790_abnormal_immune_system0.79232767
125MP0002972_abnormal_cardiac_muscle0.78840380
126MP0005248_abnormal_Harderian_gland0.78699532
127MP0002098_abnormal_vibrissa_morphology0.78142174
128MP0005647_abnormal_sex_gland0.77947954
129MP0009765_abnormal_xenobiotic_induced0.76914123
130MP0003453_abnormal_keratinocyte_physiol0.76489036
131MP0001915_intracranial_hemorrhage0.76035744
132MP0003634_abnormal_glial_cell0.75695532
133MP0001533_abnormal_skeleton_physiology0.74988424
134MP0005197_abnormal_uvea_morphology0.74375636
135MP0003633_abnormal_nervous_system0.73576141
136MP0000598_abnormal_liver_morphology0.73197988
137MP0002127_abnormal_cardiovascular_syste0.72945801
138MP0009745_abnormal_behavioral_response0.72939106
139MP0006276_abnormal_autonomic_nervous0.72722978
140MP0005397_hematopoietic_system_phenotyp0.70718766
141MP0001545_abnormal_hematopoietic_system0.70718766
142MP0001970_abnormal_pain_threshold0.69864785
143MP0001756_abnormal_urination0.69324851
144MP0010155_abnormal_intestine_physiology0.69074804
145MP0001986_abnormal_taste_sensitivity0.68925911
146MP0001984_abnormal_olfaction0.68486799
147MP0005025_abnormal_response_to0.65634580
148MP0004947_skin_inflammation0.64414095
149MP0002136_abnormal_kidney_physiology0.64357745
150MP0002998_abnormal_bone_remodeling0.63460298
151MP0001845_abnormal_inflammatory_respons0.62759445
152MP0000249_abnormal_blood_vessel0.62082788
153MP0005334_abnormal_fat_pad0.61931892
154MP0000427_abnormal_hair_cycle0.61637892
155MP0005671_abnormal_response_to0.61294411
156MP0005166_decreased_susceptibility_to0.61261933
157MP0005409_darkened_coat_color0.59057365
158MP0009642_abnormal_blood_homeostasis0.58534364
159MP0002796_impaired_skin_barrier0.57396822
160MP0003632_abnormal_nervous_system0.56929088
161MP0005310_abnormal_salivary_gland0.55760651
162MP0002452_abnormal_antigen_presenting0.54097321
163MP0001853_heart_inflammation0.53734649

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.69245535
2Systemic lupus erythematosus (HP:0002725)5.68751240
3Complement deficiency (HP:0004431)5.52028560
4Pigmentary retinal degeneration (HP:0001146)5.18066720
5Glomerulonephritis (HP:0000099)4.75223540
6Deep venous thrombosis (HP:0002625)4.56175510
7Intrahepatic cholestasis (HP:0001406)4.55995203
8Bony spicule pigmentary retinopathy (HP:0007737)4.09828314
9Chorioretinal atrophy (HP:0000533)4.00195557
10Abnormality of complement system (HP:0005339)3.99844603
11Prolonged partial thromboplastin time (HP:0003645)3.96517820
12Xanthomatosis (HP:0000991)3.95972156
13Abolished electroretinogram (ERG) (HP:0000550)3.95192451
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.93197937
15Hyperventilation (HP:0002883)3.89818579
16Joint hemorrhage (HP:0005261)3.83282885
17Hyperlipoproteinemia (HP:0010980)3.63469348
18Prolonged bleeding time (HP:0003010)3.55842728
19Fair hair (HP:0002286)3.44080111
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42646535
21Congenital, generalized hypertrichosis (HP:0004540)3.32256118
22Dyschromatopsia (HP:0007641)3.28181315
23Abnormal rod and cone electroretinograms (HP:0008323)3.19754227
24Retinal atrophy (HP:0001105)3.19480342
25Central scotoma (HP:0000603)3.10099332
26Abnormality of the renal cortex (HP:0011035)3.09512018
27Pancreatic cysts (HP:0001737)3.05486026
28Generalized hypopigmentation of hair (HP:0011358)2.97723179
29Stomatitis (HP:0010280)2.95605416
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.93504253
31Abnormality of macular pigmentation (HP:0008002)2.92497252
32Widely spaced teeth (HP:0000687)2.92286519
33Decreased central vision (HP:0007663)2.89801504
34Abnormality of the common coagulation pathway (HP:0010990)2.87105985
35Progressive visual loss (HP:0000529)2.86990223
36Abnormality of the renal medulla (HP:0100957)2.85850830
37Absent speech (HP:0001344)2.84778986
38Axonal loss (HP:0003447)2.82680911
39Macular degeneration (HP:0000608)2.82635111
40Hypercholesterolemia (HP:0003124)2.81891336
41Nephritis (HP:0000123)2.80146874
42Thick nail (HP:0001805)2.78759130
43Myocardial infarction (HP:0001658)2.78353255
44Cone-rod dystrophy (HP:0000548)2.76345583
45Epidermoid cyst (HP:0200040)2.75765186
46Hypoalphalipoproteinemia (HP:0003233)2.75641539
47Thyroid-stimulating hormone excess (HP:0002925)2.74653969
48Neurofibrillary tangles (HP:0002185)2.71278893
49Esophageal varix (HP:0002040)2.70313280
50Hypobetalipoproteinemia (HP:0003563)2.70133192
51Abnormality of methionine metabolism (HP:0010901)2.66819944
52Amyloidosis (HP:0011034)2.66538544
53Portal hypertension (HP:0001409)2.60251706
54Fat malabsorption (HP:0002630)2.59578678
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.56544620
56Abnormality of secondary sexual hair (HP:0009888)2.56517492
57Abnormality of the axillary hair (HP:0100134)2.56517492
58True hermaphroditism (HP:0010459)2.55625996
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.54678412
60Scotoma (HP:0000575)2.54553951
61Hypolipoproteinemia (HP:0010981)2.52345413
62Vascular calcification (HP:0004934)2.51975684
63Stomach cancer (HP:0012126)2.50616881
64Pancreatic fibrosis (HP:0100732)2.50399007
65Decreased circulating renin level (HP:0003351)2.48901542
66Polydipsia (HP:0001959)2.48634913
67Abnormal drinking behavior (HP:0030082)2.48634913
68Nephronophthisis (HP:0000090)2.48523002
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47530482
70Dysostosis multiplex (HP:0000943)2.46230115
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45341796
72Conjugated hyperbilirubinemia (HP:0002908)2.44922811
73Vacuolated lymphocytes (HP:0001922)2.42321181
74Abnormality of midbrain morphology (HP:0002418)2.41775616
75Molar tooth sign on MRI (HP:0002419)2.41775616
76Petechiae (HP:0000967)2.41226255
77Vitreoretinal degeneration (HP:0000655)2.41217930
78Congenital sensorineural hearing impairment (HP:0008527)2.39526540
79Attenuation of retinal blood vessels (HP:0007843)2.36725684
80Menorrhagia (HP:0000132)2.34525916
81Choroideremia (HP:0001139)2.34213855
82Increased cerebral lipofuscin (HP:0011813)2.32457002
83Gaze-evoked nystagmus (HP:0000640)2.31516931
84Epistaxis (HP:0000421)2.28341733
85Hemorrhage of the eye (HP:0011885)2.26599088
86Cupped ear (HP:0000378)2.26474311
87Abnormality of the hepatic vasculature (HP:0006707)2.25463562
88Gingival bleeding (HP:0000225)2.24961967
89Increased mean platelet volume (HP:0011877)2.24782748
90Pendular nystagmus (HP:0012043)2.24486660
91Renal cortical cysts (HP:0000803)2.23592736
92Blue irides (HP:0000635)2.21454839
93Peripheral demyelination (HP:0011096)2.19535084
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.17967471
95Recurrent bacterial skin infections (HP:0005406)2.17482465
96Abnormality of liposaccharide metabolism (HP:0010968)2.16051458
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.16051458
98Abnormality of glycolipid metabolism (HP:0010969)2.16051458
99Hyperammonemia (HP:0001987)2.14848096
100Steatorrhea (HP:0002570)2.13243193
101Polyuria (HP:0000103)2.13213540
102Recurrent gram-negative bacterial infections (HP:0005420)2.12759985
103Cardiovascular calcification (HP:0011915)2.11682976
104Photophobia (HP:0000613)2.11225908
105Spontaneous hematomas (HP:0007420)2.10359408
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.09986782
107Thyroiditis (HP:0100646)2.08703904
108Purpura (HP:0000979)2.08078776
109Tubulointerstitial fibrosis (HP:0005576)2.05521294
110Tubular atrophy (HP:0000092)2.04283981
111Congenital hepatic fibrosis (HP:0002612)2.03938917
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03793523
113Abnormality of polysaccharide metabolism (HP:0011012)2.03793523
114Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03793523
115Hepatosplenomegaly (HP:0001433)2.02614189
116Optic neuritis (HP:0100653)2.02418807
117Retrobulbar optic neuritis (HP:0100654)2.02418807
118Adactyly (HP:0009776)2.02300150
119Type II lissencephaly (HP:0007260)2.01363790
120Abnormal platelet volume (HP:0011876)2.01152981
121Papillary thyroid carcinoma (HP:0002895)1.99452032
122Ketosis (HP:0001946)1.99293738
123Abnormality of the intrinsic pathway (HP:0010989)1.98749974
124Mucopolysacchariduria (HP:0008155)1.95743843
125Urinary glycosaminoglycan excretion (HP:0003541)1.95743843
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93749663
127Hypoglycemic seizures (HP:0002173)1.92382362
128Hypokalemic alkalosis (HP:0001949)1.92127418
129Hepatocellular carcinoma (HP:0001402)1.92061524
130Tubulointerstitial abnormality (HP:0001969)1.91782608
131Mitral stenosis (HP:0001718)1.90920826
132Abnormality of glycine metabolism (HP:0010895)1.89811004
133Abnormality of serine family amino acid metabolism (HP:0010894)1.89811004
134Recurrent abscess formation (HP:0002722)1.85500709
135Hyperglycinemia (HP:0002154)1.84464777
136Type II diabetes mellitus (HP:0005978)1.84413331
137Febrile seizures (HP:0002373)1.83227447
138Submucous cleft hard palate (HP:0000176)1.81470522
139Hypoglycemic coma (HP:0001325)1.81212135
140Parakeratosis (HP:0001036)1.80805904
141Keratoconjunctivitis (HP:0001096)1.80584487
142Slow saccadic eye movements (HP:0000514)1.80192175
143Alkalosis (HP:0001948)1.79604299
144Chronic hepatic failure (HP:0100626)1.79371704
145Metabolic alkalosis (HP:0200114)1.78736313
146Hematochezia (HP:0002573)1.78468502
147Hyperglycinuria (HP:0003108)1.78280481
148Keratoconus (HP:0000563)1.78122208
149Increased corneal curvature (HP:0100692)1.78122208
150Pulmonary embolism (HP:0002204)1.78109346
151Genetic anticipation (HP:0003743)1.77167920
152Amelogenesis imperfecta (HP:0000705)1.76415157
153Inability to walk (HP:0002540)1.76079541
154Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76016038
155Subcapsular cataract (HP:0000523)1.75718809
156Conjunctival telangiectasia (HP:0000524)1.75165177
157Agitation (HP:0000713)1.74753585
158Alopecia of scalp (HP:0002293)1.74674549
159Hypophosphatemic rickets (HP:0004912)1.73827281
160Retinitis pigmentosa (HP:0000510)1.73671279
161Palmar hyperkeratosis (HP:0010765)1.72758434
162Broad-based gait (HP:0002136)1.72383668
163Absent/shortened dynein arms (HP:0200106)1.71816410
164Dynein arm defect of respiratory motile cilia (HP:0012255)1.71816410
1653-Methylglutaconic aciduria (HP:0003535)1.71119673
166Erythroderma (HP:0001019)1.70408522
167Pachygyria (HP:0001302)1.69631890
168Medial flaring of the eyebrow (HP:0010747)1.69272992
169Pancreatic islet-cell hyperplasia (HP:0004510)1.68460382
170Abnormality of the prostate (HP:0008775)1.68434004
171Short tibia (HP:0005736)1.67598547
172Drooling (HP:0002307)1.67457573
173Abnormality of renin-angiotensin system (HP:0000847)1.66196733
174Palmoplantar hyperkeratosis (HP:0000972)1.65042603
175Syncope (HP:0001279)1.64500527
176Keratoconjunctivitis sicca (HP:0001097)1.64352584
177Progressive cerebellar ataxia (HP:0002073)1.64153806
178Abnormal urine output (HP:0012590)1.62728416
179Tented upper lip vermilion (HP:0010804)1.61152226
180Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.60995179
181Degeneration of the lateral corticospinal tracts (HP:0002314)1.60995179
182Curly hair (HP:0002212)1.60406089
183Volvulus (HP:0002580)1.58892561
184Disproportionate short-trunk short stature (HP:0003521)1.56213853
185Metaphyseal dysplasia (HP:0100255)1.55604504
186Autoimmune thrombocytopenia (HP:0001973)1.54056310
187Decreased electroretinogram (ERG) amplitude (HP:0000654)1.53455334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.86875089
2TGFBR23.72992810
3TAOK32.91576460
4MAP4K22.73896952
5GRK12.63303624
6BMPR1B2.49201188
7INSRR2.45895518
8EPHB12.43533323
9STK392.42525385
10MAPK152.25302827
11ADRBK22.14986377
12CAMK1D2.14831385
13NUAK12.06542299
14MAP3K142.05080845
15CAMK1G2.05025588
16ACVR1B1.98768204
17IRAK31.96245507
18TYK21.87265976
19CASK1.86017326
20STK38L1.71476192
21FGFR41.69194813
22PKN11.58636784
23PINK11.56856511
24MAPK131.53988855
25TIE11.53263239
26CSF1R1.53211274
27MET1.51335798
28TEC1.50483136
29TGFBR11.49847586
30SIK11.49066191
31WNK31.45605864
32JAK11.44769169
33OXSR11.43399124
34GRK71.42166864
35MST41.42154242
36IRAK21.38560782
37FGFR21.38541526
38SGK4941.34401767
39SGK2231.34401767
40NEK61.32137669
41MAPK71.30382238
42PTK61.25030919
43ERN11.23385701
44BLK1.22657920
45TXK1.21443504
46PTK2B1.19079601
47ITK1.18817294
48CLK11.18786605
49DAPK21.18085356
50MAP3K41.15005261
51PAK31.14913603
52TBK11.14131527
53LATS11.12701791
54IKBKE1.09087558
55TRIM281.07433563
56ICK1.06789436
57ERBB21.06632487
58SGK21.06052743
59PRPF4B1.01875822
60EPHA31.01652434
61MARK11.00329642
62NEK90.98778044
63SGK30.98211039
64IRAK40.96936281
65PBK0.94156058
66MAP3K130.93692374
67WNK40.92049345
68PRKAA20.91571190
69GSK3A0.87710325
70FGR0.87496548
71IRAK10.86155751
72CAMKK20.83999113
73CSK0.83245370
74OBSCN0.82797048
75MAPKAPK30.80641340
76ERBB30.80618769
77CSNK1A1L0.79557777
78NTRK20.77598136
79PRKCE0.77374562
80WNK10.77067982
81BTK0.76060871
82KDR0.76031211
83JAK20.75925835
84MAPK120.75692878
85SYK0.75445753
86BRSK20.74485478
87BCR0.73946006
88EPHB20.73924974
89PIK3CG0.72817400
90MAP2K70.72368503
91IKBKB0.71683161
92PLK20.69949915
93TRPM70.69830489
94NLK0.68446445
95CCNB10.66807105
96CHUK0.66426473
97PDGFRB0.65971740
98STK30.64666748
99ADRBK10.64546685
100PIK3CA0.64028671
101CSNK1G20.63866864
102YES10.63152503
103BCKDK0.62982669
104TNK20.62616963
105RIPK40.62471084
106ZAP700.62425046
107IGF1R0.62403461
108MAP2K60.62183364
109LYN0.60593603
110MARK30.59154185
111EGFR0.56895458
112PRKCQ0.56694033
113ZAK0.56574366
114LMTK20.55516348
115CDK60.54668567
116MAP3K50.53581817
117HCK0.53243108
118CSNK1G30.52399922
119MAP3K30.51402341
120PRKD10.50981607
121CDK120.50393608
122CSNK1G10.49944727
123EPHA40.49518643
124RIPK10.49436676
125PDPK10.49135671
126KIT0.48880081
127MAP2K20.48235014
128PDK20.48189399
129STK240.48060353
130STK100.46854698
131CDK30.46622565
132PRKG10.45694028
133PRKCZ0.45184745
134LCK0.45105788
135FGFR30.45066831
136MAP3K70.44900662
137FES0.44865151
138PTK20.44049260
139ABL10.43464107
140FER0.43001410
141DMPK0.42069504
142TNIK0.41921506
143CAMK40.41435120
144CAMK2A0.41230449
145AKT30.40650718
146MAP3K100.39961834
147MAPKAPK50.35605997
148FLT30.34798095
149PRKACA0.34404896
150MAP3K60.33850263
151MYLK0.32494584

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.96507674
2Staphylococcus aureus infection_Homo sapiens_hsa051503.30653166
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.28245072
4Complement and coagulation cascades_Homo sapiens_hsa046102.91651604
5Nitrogen metabolism_Homo sapiens_hsa009102.91648492
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37817729
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30368426
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08508245
9ABC transporters_Homo sapiens_hsa020101.99559047
10Caffeine metabolism_Homo sapiens_hsa002321.98796721
11Arginine biosynthesis_Homo sapiens_hsa002201.97401570
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94054234
13Tryptophan metabolism_Homo sapiens_hsa003801.93066171
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92343856
15Histidine metabolism_Homo sapiens_hsa003401.89232360
16Platelet activation_Homo sapiens_hsa046111.88874175
17Fatty acid elongation_Homo sapiens_hsa000621.85093287
18Retinol metabolism_Homo sapiens_hsa008301.81868696
19Steroid biosynthesis_Homo sapiens_hsa001001.79982849
20Dorso-ventral axis formation_Homo sapiens_hsa043201.64184022
21Peroxisome_Homo sapiens_hsa041461.62730230
22Asthma_Homo sapiens_hsa053101.61708822
23Fatty acid degradation_Homo sapiens_hsa000711.60597751
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.60557449
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58294501
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55415625
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54145151
28Chemical carcinogenesis_Homo sapiens_hsa052041.53343718
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49740977
30Ovarian steroidogenesis_Homo sapiens_hsa049131.47791249
31Butanoate metabolism_Homo sapiens_hsa006501.47169585
32PPAR signaling pathway_Homo sapiens_hsa033201.46248345
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46131141
34Circadian rhythm_Homo sapiens_hsa047101.46050389
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41997673
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.41359110
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41301235
38Hematopoietic cell lineage_Homo sapiens_hsa046401.38518776
39Fatty acid metabolism_Homo sapiens_hsa012121.38320052
40Serotonergic synapse_Homo sapiens_hsa047261.29441065
41Autoimmune thyroid disease_Homo sapiens_hsa053201.27732217
42Morphine addiction_Homo sapiens_hsa050321.27358302
43beta-Alanine metabolism_Homo sapiens_hsa004101.26523185
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25085445
45Lysosome_Homo sapiens_hsa041421.24118540
46Graft-versus-host disease_Homo sapiens_hsa053321.22237369
47Allograft rejection_Homo sapiens_hsa053301.20254011
48Collecting duct acid secretion_Homo sapiens_hsa049661.17857257
49Sulfur metabolism_Homo sapiens_hsa009201.15650775
50Vitamin digestion and absorption_Homo sapiens_hsa049771.14876685
51Renin secretion_Homo sapiens_hsa049241.14864816
52Olfactory transduction_Homo sapiens_hsa047401.14212057
53Propanoate metabolism_Homo sapiens_hsa006401.12859181
54Bile secretion_Homo sapiens_hsa049761.12540273
55Other glycan degradation_Homo sapiens_hsa005111.12307909
56Circadian entrainment_Homo sapiens_hsa047131.11620587
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11359051
58Lysine degradation_Homo sapiens_hsa003101.11011323
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10633950
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09958403
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.06196740
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03317462
63Starch and sucrose metabolism_Homo sapiens_hsa005001.01914434
64Drug metabolism - other enzymes_Homo sapiens_hsa009831.01791718
65Glutamatergic synapse_Homo sapiens_hsa047240.94516910
66Phenylalanine metabolism_Homo sapiens_hsa003600.93340373
67Selenocompound metabolism_Homo sapiens_hsa004500.90201963
68Fat digestion and absorption_Homo sapiens_hsa049750.89783597
69Pancreatic secretion_Homo sapiens_hsa049720.87344802
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87097937
71Salivary secretion_Homo sapiens_hsa049700.86690413
72Long-term depression_Homo sapiens_hsa047300.83305722
73GABAergic synapse_Homo sapiens_hsa047270.81982380
74Tyrosine metabolism_Homo sapiens_hsa003500.79300292
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79239856
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.78806746
77Type I diabetes mellitus_Homo sapiens_hsa049400.78462960
78Ether lipid metabolism_Homo sapiens_hsa005650.78367515
79ECM-receptor interaction_Homo sapiens_hsa045120.78309028
80Ras signaling pathway_Homo sapiens_hsa040140.76469701
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.75382504
82Basal transcription factors_Homo sapiens_hsa030220.75321403
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73071290
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.72065476
85Pertussis_Homo sapiens_hsa051330.71318165
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69657022
87Nicotine addiction_Homo sapiens_hsa050330.69531011
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68106271
89Taste transduction_Homo sapiens_hsa047420.68008465
90cAMP signaling pathway_Homo sapiens_hsa040240.66566787
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64403103
92Glycerolipid metabolism_Homo sapiens_hsa005610.63954948
93Regulation of autophagy_Homo sapiens_hsa041400.63722666
94Osteoclast differentiation_Homo sapiens_hsa043800.63651713
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63584666
96Arginine and proline metabolism_Homo sapiens_hsa003300.63323124
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61242438
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61101128
99Oxytocin signaling pathway_Homo sapiens_hsa049210.60949012
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59788184
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59439076
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58121736
103Sphingolipid metabolism_Homo sapiens_hsa006000.57883716
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57793150
105Linoleic acid metabolism_Homo sapiens_hsa005910.57560948
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56374778
107T cell receptor signaling pathway_Homo sapiens_hsa046600.54440833
108Calcium signaling pathway_Homo sapiens_hsa040200.53988010
109Arachidonic acid metabolism_Homo sapiens_hsa005900.52574509
110Rap1 signaling pathway_Homo sapiens_hsa040150.50953063
111Prion diseases_Homo sapiens_hsa050200.50601551
112Gastric acid secretion_Homo sapiens_hsa049710.49636721
113Dopaminergic synapse_Homo sapiens_hsa047280.49525305
114Insulin resistance_Homo sapiens_hsa049310.48628626
115Malaria_Homo sapiens_hsa051440.48353884
116FoxO signaling pathway_Homo sapiens_hsa040680.47351282
117Primary immunodeficiency_Homo sapiens_hsa053400.46880234
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45427827
119Folate biosynthesis_Homo sapiens_hsa007900.45318505
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44941701
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44781593
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.44400206
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44235837
124Hepatitis C_Homo sapiens_hsa051600.42675030
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.41871195
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34799581
127Toxoplasmosis_Homo sapiens_hsa051450.33087501
128Vitamin B6 metabolism_Homo sapiens_hsa007500.32545439
129Notch signaling pathway_Homo sapiens_hsa043300.32257413
130Mineral absorption_Homo sapiens_hsa049780.31284286
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.30940284
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29002260
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.28934324
134Pyruvate metabolism_Homo sapiens_hsa006200.26682613
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26155490
136Glutathione metabolism_Homo sapiens_hsa004800.25676847
137Leishmaniasis_Homo sapiens_hsa051400.25411674
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25183483
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24624063
140Tuberculosis_Homo sapiens_hsa051520.24287676
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23855288
142B cell receptor signaling pathway_Homo sapiens_hsa046620.23058975
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22626716
144Type II diabetes mellitus_Homo sapiens_hsa049300.21626424
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21165679
146Rheumatoid arthritis_Homo sapiens_hsa053230.20557576
147Fatty acid biosynthesis_Homo sapiens_hsa000610.20292715
148Influenza A_Homo sapiens_hsa051640.19379955
149Chemokine signaling pathway_Homo sapiens_hsa040620.18271932
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.17713471
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17092063
152Phagosome_Homo sapiens_hsa041450.16089322

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