FRMD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.79010874
2central nervous system myelination (GO:0022010)4.79010874
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.77672165
4cardiac myofibril assembly (GO:0055003)4.49186759
5postsynaptic membrane organization (GO:0001941)4.45682073
6regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.39098128
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.31652790
8sarcomere organization (GO:0045214)4.21814137
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.20383013
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11025686
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99611428
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.99358028
13myofibril assembly (GO:0030239)3.97131967
14negative regulation of potassium ion transmembrane transport (GO:1901380)3.96828817
15cell communication by electrical coupling (GO:0010644)3.79461180
16negative regulation of protein localization to cell surface (GO:2000009)3.79172683
17regulation of actin filament-based movement (GO:1903115)3.78774117
18regulation of cell communication by electrical coupling (GO:0010649)3.78358878
19regulation of membrane repolarization (GO:0060306)3.73038933
20regulation of relaxation of muscle (GO:1901077)3.71993753
21cardiac muscle contraction (GO:0060048)3.61261248
22cell communication involved in cardiac conduction (GO:0086065)3.61176488
23detection of calcium ion (GO:0005513)3.60979300
24neuron cell-cell adhesion (GO:0007158)3.59175810
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57505819
26regulation of sarcomere organization (GO:0060297)3.57487074
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.54397145
28presynaptic membrane organization (GO:0097090)3.47030380
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45883306
30presynaptic membrane assembly (GO:0097105)3.43835785
31sarcoplasmic reticulum calcium ion transport (GO:0070296)3.39337022
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36855618
33regulation of cardiac muscle cell contraction (GO:0086004)3.31136304
34adult heart development (GO:0007512)3.29863683
35ventricular cardiac muscle cell action potential (GO:0086005)3.28306496
36positive regulation of potassium ion transmembrane transport (GO:1901381)3.27881331
37establishment of mitochondrion localization (GO:0051654)3.23834886
38cardiac muscle hypertrophy (GO:0003300)3.22967394
39neurotransmitter-gated ion channel clustering (GO:0072578)3.20973157
40vocalization behavior (GO:0071625)3.19135602
41positive regulation of action potential (GO:0045760)3.17576199
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17055304
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.14679722
44response to epinephrine (GO:0071871)3.14626457
45cellular response to epinephrine stimulus (GO:0071872)3.13812838
46eye photoreceptor cell differentiation (GO:0001754)3.12226963
47photoreceptor cell differentiation (GO:0046530)3.12226963
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11912704
49regulation of striated muscle contraction (GO:0006942)3.11494057
50regulation of cardiac muscle contraction (GO:0055117)3.09461907
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08534252
52glutamate secretion (GO:0014047)3.07889725
53neuronal action potential propagation (GO:0019227)3.07457926
54dendritic spine morphogenesis (GO:0060997)3.07209749
55striated muscle hypertrophy (GO:0014897)3.06597958
56protein heterotetramerization (GO:0051290)3.06556195
57cullin deneddylation (GO:0010388)3.06426569
58regulation of synapse structural plasticity (GO:0051823)3.02463725
59regulation of calcium ion transmembrane transporter activity (GO:1901019)3.01591318
60regulation of calcium ion transmembrane transport (GO:1903169)3.01591318
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00963065
62neuron recognition (GO:0008038)3.00756400
63regulation of voltage-gated calcium channel activity (GO:1901385)2.97486910
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96055579
65cardiac conduction (GO:0061337)2.95789094
66negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94978739
67neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.93592047
68microtubule polymerization or depolymerization (GO:0031109)2.93334158
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92400061
70synaptic vesicle maturation (GO:0016188)2.90902252
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.90036886
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89275150
73cerebral cortex radially oriented cell migration (GO:0021799)2.88792570
74cardiac muscle cell development (GO:0055013)2.88555119
75regulation of centriole replication (GO:0046599)2.88166504
76actomyosin structure organization (GO:0031032)2.87611551
77potassium ion import (GO:0010107)2.87526250
78negative regulation of neurotransmitter secretion (GO:0046929)2.87057442
79positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.86945072
80positive regulation of potassium ion transport (GO:0043268)2.85930588
81cardiac muscle cell action potential (GO:0086001)2.85006214
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84882383
83neuronal ion channel clustering (GO:0045161)2.84071137
84cellular response to monoamine stimulus (GO:0071868)2.83996622
85cellular response to catecholamine stimulus (GO:0071870)2.83996622
86regulation of heart rate by cardiac conduction (GO:0086091)2.83328955
87myelination (GO:0042552)2.82380936
88adult walking behavior (GO:0007628)2.81593165
89regulation of glutamate receptor signaling pathway (GO:1900449)2.80732745
90multicellular organismal signaling (GO:0035637)2.79664751
91righting reflex (GO:0060013)2.79140941
92ensheathment of neurons (GO:0007272)2.77873342
93axon ensheathment (GO:0008366)2.77873342
94synaptic vesicle exocytosis (GO:0016079)2.77869089
95pyrimidine nucleobase catabolic process (GO:0006208)2.77586662
96cardiac muscle cell action potential involved in contraction (GO:0086002)2.77418135
97relaxation of cardiac muscle (GO:0055119)2.77194772
98cardiac muscle tissue morphogenesis (GO:0055008)2.77131470
99glutamate receptor signaling pathway (GO:0007215)2.76379860
100response to catecholamine (GO:0071869)2.75885925
101response to monoamine (GO:0071867)2.75885925
102negative regulation of neurotransmitter transport (GO:0051589)2.75281554
103membrane assembly (GO:0071709)2.75008580
104regulation of synaptic vesicle exocytosis (GO:2000300)2.73864902
105ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.72005621
106transmission of nerve impulse (GO:0019226)2.71788869
107membrane depolarization during action potential (GO:0086010)2.70778695
108axonal fasciculation (GO:0007413)2.70446549
109synaptic vesicle docking involved in exocytosis (GO:0016081)2.69405774
110calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69012144
111synaptic transmission, glutamatergic (GO:0035249)2.67389938
112locomotory exploration behavior (GO:0035641)2.66960025
113protein localization to synapse (GO:0035418)2.66157795
114striated muscle contraction (GO:0006941)2.65253775
115cardiac cell development (GO:0055006)2.65168791
116regulation of potassium ion transmembrane transport (GO:1901379)2.65086426
117regulation of Rac protein signal transduction (GO:0035020)2.64806150
118protein deneddylation (GO:0000338)2.63798260
119L-amino acid import (GO:0043092)2.60095857
120DNA double-strand break processing (GO:0000729)2.58439593
121DNA replication-dependent nucleosome assembly (GO:0006335)2.56252362
122DNA replication-dependent nucleosome organization (GO:0034723)2.56252362
123mechanosensory behavior (GO:0007638)2.56187537
124retinal ganglion cell axon guidance (GO:0031290)2.55744384
125startle response (GO:0001964)2.54435616
126long-chain fatty acid biosynthetic process (GO:0042759)2.51400395
127positive regulation of synapse assembly (GO:0051965)2.50469854
128neuron-neuron synaptic transmission (GO:0007270)2.49164245
129amino acid import (GO:0043090)2.47933414
130C4-dicarboxylate transport (GO:0015740)2.46798920
131auditory behavior (GO:0031223)2.42823716
132nucleobase catabolic process (GO:0046113)2.41793735
133gamma-aminobutyric acid transport (GO:0015812)2.40863443
134microtubule depolymerization (GO:0007019)2.40128030
135ganglion development (GO:0061548)2.38011343
136cerebellar Purkinje cell differentiation (GO:0021702)2.37125719
137glial cell proliferation (GO:0014009)2.34342620
138regulation of respiratory system process (GO:0044065)2.34092699
139exploration behavior (GO:0035640)2.33658354
140regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30130284
141neurotransmitter secretion (GO:0007269)2.28614333
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.27381064
143dendrite morphogenesis (GO:0048813)2.27043593
144axon cargo transport (GO:0008088)2.25397890
145innervation (GO:0060384)2.25255046
146regulation of dendritic spine morphogenesis (GO:0061001)2.24724065
147retinal cone cell development (GO:0046549)2.24440823
148synapse assembly (GO:0007416)2.23670859
149regulation of synapse assembly (GO:0051963)2.21202367
150glycosphingolipid biosynthetic process (GO:0006688)2.19896863
151platelet dense granule organization (GO:0060155)2.18858040
152regulation of DNA endoreduplication (GO:0032875)2.18743764
153regulation of dendritic spine development (GO:0060998)2.18141443
154central nervous system projection neuron axonogenesis (GO:0021952)2.17904041
155centriole replication (GO:0007099)2.17529316
156regulation of vesicle fusion (GO:0031338)2.15748154
157sodium ion export (GO:0071436)2.15543475
158cellular potassium ion homeostasis (GO:0030007)2.13388891
159microtubule nucleation (GO:0007020)2.13139373
160proline transport (GO:0015824)2.13086031
161neuromuscular synaptic transmission (GO:0007274)2.12864483
162regulation of neuronal synaptic plasticity (GO:0048168)2.12444928
163chromatin remodeling at centromere (GO:0031055)2.11919488
164layer formation in cerebral cortex (GO:0021819)2.11071688
165retina layer formation (GO:0010842)2.10538139
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.09000059
167neurotransmitter uptake (GO:0001504)2.08369452
168inner ear receptor stereocilium organization (GO:0060122)2.08253165
169limb bud formation (GO:0060174)2.07449961
170replication fork processing (GO:0031297)2.07217358
171regulation of excitatory postsynaptic membrane potential (GO:0060079)2.07193082
172cytoskeleton-dependent intracellular transport (GO:0030705)2.07074463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38238484
2GBX2_23144817_ChIP-Seq_PC3_Human3.42425863
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.24166148
4E2F7_22180533_ChIP-Seq_HELA_Human3.22962625
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64037928
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61344368
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51770532
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.43498466
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32349033
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29134242
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29134242
12IGF1R_20145208_ChIP-Seq_DFB_Human2.26095610
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19960140
14DROSHA_22980978_ChIP-Seq_HELA_Human2.17904893
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.15018827
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.14767621
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12627453
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10659871
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08166705
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05520816
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05238210
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03808739
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.00856975
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98618528
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.98349963
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.95840945
27REST_21632747_ChIP-Seq_MESCs_Mouse1.87858855
28EWS_26573619_Chip-Seq_HEK293_Human1.79398788
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78940160
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73224620
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.73158960
32TAF15_26573619_Chip-Seq_HEK293_Human1.68050909
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63843486
34* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62729767
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62399706
36AR_21572438_ChIP-Seq_LNCaP_Human1.62314389
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62011715
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.60834188
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60268833
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58185476
41SMAD4_21799915_ChIP-Seq_A2780_Human1.56896283
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55160428
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.54314783
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51331410
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47428881
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46665634
47AR_21909140_ChIP-Seq_LNCAP_Human1.46472068
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45957391
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45382992
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45318839
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44239366
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42682447
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.42213554
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38896146
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.36820001
56VDR_22108803_ChIP-Seq_LS180_Human1.35538119
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34034944
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32326307
59SOX9_26525672_Chip-Seq_HEART_Mouse1.31993808
60STAT3_23295773_ChIP-Seq_U87_Human1.31555200
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29341883
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28874359
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28476569
64* P300_19829295_ChIP-Seq_ESCs_Human1.27389115
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26900760
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25575833
67ER_23166858_ChIP-Seq_MCF-7_Human1.24394809
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22273727
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22012131
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21048933
71TP53_16413492_ChIP-PET_HCT116_Human1.20671254
72* ARNT_22903824_ChIP-Seq_MCF-7_Human1.20379483
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20337463
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19830470
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19268015
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19104945
77* TCF4_23295773_ChIP-Seq_U87_Human1.18798009
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18152524
79* AHR_22903824_ChIP-Seq_MCF-7_Human1.18092393
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.17033353
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15487009
82TP53_18474530_ChIP-ChIP_U2OS_Human1.15485765
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13293298
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.12629502
85* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12000845
86JUN_21703547_ChIP-Seq_K562_Human1.11093425
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10727653
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10629778
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10562965
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09616832
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09616832
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08537350
93* AR_19668381_ChIP-Seq_PC3_Human1.07988893
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07666550
95ZNF274_21170338_ChIP-Seq_K562_Hela1.07121025
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06592825
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06538783
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06350832
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06301306
100CBP_20019798_ChIP-Seq_JUKART_Human1.06301306
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05891289
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05466948
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05001351
104BCAT_22108803_ChIP-Seq_LS180_Human1.04976620
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.03969531
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03864004
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02870068
108RNF2_27304074_Chip-Seq_NSC_Mouse1.02337450
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.01114334
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00911077
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00856478
112* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00796026
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00328221
114TCF4_22108803_ChIP-Seq_LS180_Human1.00117228
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00004195
116* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99907888
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99629008
118AR_25329375_ChIP-Seq_VCAP_Human0.99609314
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99515413
120* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98355923
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.98150121
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.97484467
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97346001
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.97064061
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97017463
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.96717440
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96587328
128* P53_22387025_ChIP-Seq_ESCs_Mouse0.96270811
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95827849
130RUNX2_22187159_ChIP-Seq_PCA_Human0.95811087
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95448122
132* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94351397
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93492544
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93181564
135FUS_26573619_Chip-Seq_HEK293_Human0.91753442
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89833828
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89797044
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.89622319
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.89622319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.09286018
2MP0003880_abnormal_central_pattern3.39817543
3MP0000751_myopathy3.26068476
4MP0004215_abnormal_myocardial_fiber3.21948601
5MP0004859_abnormal_synaptic_plasticity3.19829795
6MP0004084_abnormal_cardiac_muscle3.01602630
7MP0003646_muscle_fatigue2.89547322
8MP0004036_abnormal_muscle_relaxation2.47090181
9MP0003635_abnormal_synaptic_transmissio2.43081767
10MP0004270_analgesia2.42379602
11MP0003137_abnormal_impulse_conducting2.31720885
12MP0005330_cardiomyopathy2.17451111
13MP0005423_abnormal_somatic_nervous2.14208161
14MP0002272_abnormal_nervous_system2.09339080
15MP0002064_seizures2.07102275
16MP0009745_abnormal_behavioral_response2.06783181
17MP0000749_muscle_degeneration2.05337506
18MP0001486_abnormal_startle_reflex1.99447895
19MP0009046_muscle_twitch1.96954332
20MP0004085_abnormal_heartbeat1.95788093
21MP0002063_abnormal_learning/memory/cond1.95424897
22MP0002972_abnormal_cardiac_muscle1.94642849
23MP0004145_abnormal_muscle_electrophysio1.90945259
24MP0003950_abnormal_plasma_membrane1.90453745
25MP0002736_abnormal_nociception_after1.88575718
26MP0000778_abnormal_nervous_system1.80538727
27MP0002572_abnormal_emotion/affect_behav1.75073130
28MP0002822_catalepsy1.74582745
29MP0000920_abnormal_myelination1.74529532
30MP0008775_abnormal_heart_ventricle1.70919128
31MP0005620_abnormal_muscle_contractility1.69607525
32MP0004484_altered_response_of1.68458949
33MP0005646_abnormal_pituitary_gland1.66320994
34MP0001529_abnormal_vocalization1.65648035
35MP0004924_abnormal_behavior1.63743395
36MP0005386_behavior/neurological_phenoty1.63743395
37MP0000569_abnormal_digit_pigmentation1.62836417
38MP0002734_abnormal_mechanical_nocicepti1.58417938
39MP0004087_abnormal_muscle_fiber1.58023402
40MP0005187_abnormal_penis_morphology1.57693919
41MP0005551_abnormal_eye_electrophysiolog1.57538913
42MP0003283_abnormal_digestive_organ1.56109252
43MP0003123_paternal_imprinting1.49774537
44MP0004142_abnormal_muscle_tone1.47208918
45MP0008569_lethality_at_weaning1.42102554
46MP0003121_genomic_imprinting1.41476358
47MP0004885_abnormal_endolymph1.41195922
48MP0010094_abnormal_chromosome_stability1.40833288
49MP0006138_congestive_heart_failure1.38773274
50MP0002067_abnormal_sensory_capabilities1.38753528
51MP0000372_irregular_coat_pigmentation1.37057127
52MP0003890_abnormal_embryonic-extraembry1.36173818
53MP0009780_abnormal_chondrocyte_physiolo1.34589397
54MP0001440_abnormal_grooming_behavior1.32408229
55MP0006072_abnormal_retinal_apoptosis1.30384327
56MP0004510_myositis1.30158250
57MP0002909_abnormal_adrenal_gland1.29126106
58MP0005248_abnormal_Harderian_gland1.29048837
59MP0008058_abnormal_DNA_repair1.28447530
60MP0005645_abnormal_hypothalamus_physiol1.28284195
61MP0002106_abnormal_muscle_physiology1.27832275
62MP0006276_abnormal_autonomic_nervous1.27391846
63MP0002229_neurodegeneration1.26284237
64MP0004043_abnormal_pH_regulation1.25272571
65MP0005385_cardiovascular_system_phenoty1.24157708
66MP0001544_abnormal_cardiovascular_syste1.24157708
67MP0002882_abnormal_neuron_morphology1.22945703
68MP0004130_abnormal_muscle_cell1.22905318
69MP0001984_abnormal_olfaction1.21591375
70MP0000747_muscle_weakness1.21038496
71MP0008877_abnormal_DNA_methylation1.18867761
72MP0002735_abnormal_chemical_nociception1.18849794
73MP0005174_abnormal_tail_pigmentation1.17778853
74MP0001970_abnormal_pain_threshold1.17377292
75MP0002938_white_spotting1.15528601
76MP0005171_absent_coat_pigmentation1.15411601
77MP0002184_abnormal_innervation1.15372113
78MP0002751_abnormal_autonomic_nervous1.14875701
79MP0003690_abnormal_glial_cell1.14302935
80MP0003329_amyloid_beta_deposits1.14198411
81MP0003634_abnormal_glial_cell1.13582449
82MP0002557_abnormal_social/conspecific_i1.13524043
83MP0010630_abnormal_cardiac_muscle1.13158407
84MP0001485_abnormal_pinna_reflex1.12413107
85MP0005369_muscle_phenotype1.12094675
86MP0003011_delayed_dark_adaptation1.11948034
87MP0003119_abnormal_digestive_system1.11761105
88MP0001968_abnormal_touch/_nociception1.11551344
89MP0002234_abnormal_pharynx_morphology1.10648757
90MP0001177_atelectasis1.10227709
91MP0002066_abnormal_motor_capabilities/c1.10032005
92MP0001905_abnormal_dopamine_level1.09865554
93MP0000955_abnormal_spinal_cord1.08694317
94MP0004233_abnormal_muscle_weight1.08460512
95MP0001299_abnormal_eye_distance/1.08411131
96MP0005253_abnormal_eye_physiology1.08081023
97MP0003937_abnormal_limbs/digits/tail_de1.07228917
98MP0002127_abnormal_cardiovascular_syste1.06536843
99MP0003861_abnormal_nervous_system1.03959878
100MP0002269_muscular_atrophy1.03800508
101MP0000759_abnormal_skeletal_muscle1.03184234
102MP0004742_abnormal_vestibular_system1.02215561
103MP0001502_abnormal_circadian_rhythm1.00873848
104MP0002733_abnormal_thermal_nociception1.00452936
105MP0004811_abnormal_neuron_physiology1.00052595
106MP0002233_abnormal_nose_morphology0.99081888
107MP0001346_abnormal_lacrimal_gland0.96479495
108MP0003221_abnormal_cardiomyocyte_apopto0.96388270
109MP0000647_abnormal_sebaceous_gland0.96139537
110MP0008932_abnormal_embryonic_tissue0.95543723
111MP0002102_abnormal_ear_morphology0.94953637
112MP0001293_anophthalmia0.94402553
113MP0002752_abnormal_somatic_nervous0.93758614
114MP0000631_abnormal_neuroendocrine_gland0.92641409
115MP0003633_abnormal_nervous_system0.92377899
116MP0002638_abnormal_pupillary_reflex0.92032412
117MP0001188_hyperpigmentation0.91493296
118MP0001501_abnormal_sleep_pattern0.89099410
119MP0005623_abnormal_meninges_morphology0.89052693
120MP0003755_abnormal_palate_morphology0.88512302
121MP0000537_abnormal_urethra_morphology0.88072993
122MP0000750_abnormal_muscle_regeneration0.87791584
123MP0002152_abnormal_brain_morphology0.87421507
124MP0008057_abnormal_DNA_replication0.86024503
125MP0003136_yellow_coat_color0.83887639
126MP0003122_maternal_imprinting0.82734641
127MP0003631_nervous_system_phenotype0.82297862
128MP0003693_abnormal_embryo_hatching0.81656391
129MP0000013_abnormal_adipose_tissue0.81421041
130MP0000579_abnormal_nail_morphology0.80187625
131MP0000427_abnormal_hair_cycle0.79708341
132MP0000015_abnormal_ear_pigmentation0.79272798
133MP0002095_abnormal_skin_pigmentation0.78795119
134MP0003787_abnormal_imprinting0.77305401
135MP0003111_abnormal_nucleus_morphology0.77197886
136MP0005409_darkened_coat_color0.76998802
137MP0003077_abnormal_cell_cycle0.75229956
138MP0003943_abnormal_hepatobiliary_system0.73986811
139MP0005391_vision/eye_phenotype0.73965577
140MP0005167_abnormal_blood-brain_barrier0.73602593
141MP0004957_abnormal_blastocyst_morpholog0.73314520
142MP0002090_abnormal_vision0.72487479

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.64367814
2Atrial fibrillation (HP:0005110)5.06461614
3Primary atrial arrhythmia (HP:0001692)4.77745326
4Supraventricular tachycardia (HP:0004755)4.54446195
5Supraventricular arrhythmia (HP:0005115)4.40707600
6Syncope (HP:0001279)4.29322513
7Calf muscle hypertrophy (HP:0008981)4.22467287
8Prolonged QT interval (HP:0001657)4.16174078
9Muscle hypertrophy of the lower extremities (HP:0008968)4.14051503
10Ventricular tachycardia (HP:0004756)4.00893850
11Focal motor seizures (HP:0011153)3.98355534
12Muscle fiber splitting (HP:0003555)3.63766036
13Abnormality of the calf musculature (HP:0001430)3.59797356
14Pheochromocytoma (HP:0002666)3.57614098
15Bundle branch block (HP:0011710)3.48820425
16Exercise-induced myalgia (HP:0003738)3.33673073
17Volvulus (HP:0002580)3.28321201
18Abnormal EKG (HP:0003115)3.17057955
19Ventricular fibrillation (HP:0001663)3.14810132
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.12804450
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12804450
22Myokymia (HP:0002411)3.12440343
23Hyporeflexia of lower limbs (HP:0002600)3.08520010
24Neuroendocrine neoplasm (HP:0100634)3.03304793
25Central scotoma (HP:0000603)3.00739666
26Lipoatrophy (HP:0100578)2.97456173
27Ventricular arrhythmia (HP:0004308)2.93189808
28Subaortic stenosis (HP:0001682)2.88152314
29Abnormality of the left ventricular outflow tract (HP:0011103)2.88152314
30Abnormality of the corticospinal tract (HP:0002492)2.78791196
31Focal seizures (HP:0007359)2.77984403
32Heart block (HP:0012722)2.73033145
33Epileptic encephalopathy (HP:0200134)2.70801298
34Exercise-induced muscle cramps (HP:0003710)2.68509510
35Dilated cardiomyopathy (HP:0001644)2.60740805
36Left ventricular hypertrophy (HP:0001712)2.58939718
37EMG: myopathic abnormalities (HP:0003458)2.58480509
38Palpitations (HP:0001962)2.56125124
39Febrile seizures (HP:0002373)2.50338289
40Absent speech (HP:0001344)2.46335778
41Broad-based gait (HP:0002136)2.45515250
42Supranuclear gaze palsy (HP:0000605)2.45353201
43Abnormal atrioventricular conduction (HP:0005150)2.43499447
44Abnormality of the lower motor neuron (HP:0002366)2.43498268
45Acute necrotizing encephalopathy (HP:0006965)2.42170340
46Right ventricular cardiomyopathy (HP:0011663)2.42051930
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41398257
48Atonic seizures (HP:0010819)2.41196758
49Atrioventricular block (HP:0001678)2.40076072
50Astrocytoma (HP:0009592)2.32290230
51Abnormality of the astrocytes (HP:0100707)2.32290230
52Dysmetria (HP:0001310)2.28267752
53Ankle clonus (HP:0011448)2.28031494
54Chromsome breakage (HP:0040012)2.27996383
55Difficulty running (HP:0009046)2.26064739
56Hyperventilation (HP:0002883)2.25696407
57Spastic gait (HP:0002064)2.24636459
58Abnormal mitochondria in muscle tissue (HP:0008316)2.24307250
59Abnormality of the labia minora (HP:0012880)2.19040364
60Ependymoma (HP:0002888)2.18782221
61Dysdiadochokinesis (HP:0002075)2.18106090
62Abnormal auditory evoked potentials (HP:0006958)2.17801273
63Visual hallucinations (HP:0002367)2.17399157
64Glioma (HP:0009733)2.15824418
65Split foot (HP:0001839)2.15346291
66Scotoma (HP:0000575)2.14626176
67Myotonia (HP:0002486)2.13855114
68Neurofibrillary tangles (HP:0002185)2.13644290
69Progressive macrocephaly (HP:0004481)2.13216624
70Increased nuchal translucency (HP:0010880)2.13155411
71Lower limb muscle weakness (HP:0007340)2.12358366
72Retinal dysplasia (HP:0007973)2.11752401
73Poor eye contact (HP:0000817)2.06870173
74Termporal pattern (HP:0011008)2.06029082
75Insidious onset (HP:0003587)2.06029082
76Cutaneous finger syndactyly (HP:0010554)2.05714186
77Abnormality of the foot musculature (HP:0001436)2.05570210
78Foot dorsiflexor weakness (HP:0009027)2.04353510
79Scanning speech (HP:0002168)2.03054841
80Oligodactyly (hands) (HP:0001180)2.02706795
81Bradycardia (HP:0001662)2.02525241
82Horizontal nystagmus (HP:0000666)2.00865238
83Myoglobinuria (HP:0002913)1.99626582
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.98982715
85Tubulointerstitial nephritis (HP:0001970)1.96357105
86Urinary bladder sphincter dysfunction (HP:0002839)1.94372284
87Progressive cerebellar ataxia (HP:0002073)1.94115645
88Progressive inability to walk (HP:0002505)1.93476235
89Hemiparesis (HP:0001269)1.89812209
90Gaze-evoked nystagmus (HP:0000640)1.89584078
91Hamartoma of the eye (HP:0010568)1.88952215
92Small hand (HP:0200055)1.86248405
93Gowers sign (HP:0003391)1.86142354
94Type II lissencephaly (HP:0007260)1.85586597
95Postural instability (HP:0002172)1.85380407
96Acute encephalopathy (HP:0006846)1.82970482
97Anxiety (HP:0000739)1.82627676
98Supernumerary spleens (HP:0009799)1.82486867
99Generalized tonic-clonic seizures (HP:0002069)1.81879594
100Drooling (HP:0002307)1.80765076
101Excessive salivation (HP:0003781)1.80765076
102Aplasia/Hypoplasia of the fovea (HP:0008060)1.80414674
103Hypoplasia of the fovea (HP:0007750)1.80414674
104Urinary urgency (HP:0000012)1.79886883
105Limb dystonia (HP:0002451)1.79544849
106Leukodystrophy (HP:0002415)1.78894754
107Impaired social interactions (HP:0000735)1.78736514
108Abnormal social behavior (HP:0012433)1.78736514
109Genetic anticipation (HP:0003743)1.77202169
110Gait imbalance (HP:0002141)1.76861956
111Insomnia (HP:0100785)1.76321015
112Dialeptic seizures (HP:0011146)1.75330605
113Renal hypoplasia (HP:0000089)1.74083293
114Megalencephaly (HP:0001355)1.73977477
115Optic disc pallor (HP:0000543)1.73603471
116Peripheral hypomyelination (HP:0007182)1.72714051
117Action tremor (HP:0002345)1.71966877
118Depression (HP:0000716)1.71790558
119Hypoplasia of the brainstem (HP:0002365)1.71719630
120Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71719630
121Intention tremor (HP:0002080)1.70656786
122Poor speech (HP:0002465)1.70574963
123Meckel diverticulum (HP:0002245)1.69645304
124Abnormality of chromosome stability (HP:0003220)1.68901455
125Morphological abnormality of the inner ear (HP:0011390)1.68510588
126Cutaneous syndactyly (HP:0012725)1.68331249
127Absence seizures (HP:0002121)1.68304626
128Onion bulb formation (HP:0003383)1.68240063
129Lissencephaly (HP:0001339)1.68204148
130Athetosis (HP:0002305)1.68126371
131Decreased lacrimation (HP:0000633)1.67464593
132Morphological abnormality of the pyramidal tract (HP:0002062)1.66566322
133Abnormality of the parathyroid morphology (HP:0011766)1.66392455
134Impaired vibration sensation in the lower limbs (HP:0002166)1.65983818
135Hypoplastic pelvis (HP:0008839)1.65930329
136Mitochondrial inheritance (HP:0001427)1.65897050
137Bifid tongue (HP:0010297)1.64476558
138Neoplasm of the oral cavity (HP:0100649)1.63623547
139Abnormality of the carotid arteries (HP:0005344)1.63523802
140Abnormal lung lobation (HP:0002101)1.62879676
141Sensory axonal neuropathy (HP:0003390)1.62350859
142Cerebellar dysplasia (HP:0007033)1.61646646
143Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61636800
144Optic nerve hypoplasia (HP:0000609)1.60298865
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.59694376
146Abnormality of the ileum (HP:0001549)1.58730191
147Abnormality of the fovea (HP:0000493)1.58342099
148True hermaphroditism (HP:0010459)1.57842593
149Genital tract atresia (HP:0001827)1.57540301
150Birth length less than 3rd percentile (HP:0003561)1.54891542
151Spastic tetraplegia (HP:0002510)1.54836398
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.53955331
153Blue irides (HP:0000635)1.53471088
154Urethral obstruction (HP:0000796)1.53439572
155Pancreatic cysts (HP:0001737)1.53106390
156Inability to walk (HP:0002540)1.52489289
157Cupped ear (HP:0000378)1.51699684
158Vaginal atresia (HP:0000148)1.51248677
159Shawl scrotum (HP:0000049)1.50525788
160Hand muscle atrophy (HP:0009130)1.48796318
161Absent eyebrow (HP:0002223)1.48513970
162Medulloblastoma (HP:0002885)1.47703987
163Large earlobe (HP:0009748)1.47335821
164Congenital primary aphakia (HP:0007707)1.45483345
165Patchy hypopigmentation of hair (HP:0011365)1.44599452
166Specific learning disability (HP:0001328)1.44596339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.84115060
2MARK13.09047395
3PHKG12.84032787
4PHKG22.84032787
5STK392.74522474
6TRIM282.48757622
7NTRK32.47844352
8PKN12.06411059
9PINK12.02640472
10EPHA41.99919683
11CASK1.99327240
12OBSCN1.97169125
13BUB11.92389220
14PAK61.89236032
15EIF2AK31.88116577
16LMTK21.86471355
17MUSK1.86086599
18OXSR11.79871483
19MAP3K41.78058928
20PLK41.77525402
21UHMK11.75909383
22TSSK61.72791051
23WNK41.68946982
24DMPK1.68745474
25TNIK1.65243977
26INSRR1.64709804
27PAK31.63883204
28TTN1.63848420
29WNK11.63059654
30CAMK2D1.61580437
31MKNK21.57873917
32MET1.55036718
33WEE11.54035679
34SGK4941.52980754
35SGK2231.52980754
36EIF2AK11.49538612
37MAPK131.48705438
38MST41.48546684
39BMPR1B1.47551384
40MYLK1.41629299
41PLK31.39815578
42WNK31.36989756
43MST1R1.35171754
44MAP2K71.33045439
45CAMK2A1.26559026
46NTRK21.25023153
47ERBB31.25013207
48GRK71.24986996
49CCNB11.22362680
50PNCK1.17270127
51BCR1.16790687
52CAMK2B1.15196123
53CDC71.14741648
54TTK1.13568402
55PRKD31.13447857
56NEK11.11091648
57CDK191.09749061
58PDK41.08216839
59PDK31.08216839
60CDK51.07860497
61SIK31.07819054
62PIK3CA1.07589545
63EPHB11.07467335
64BRSK11.07180230
65FGFR21.06248076
66AKT31.04871598
67MKNK11.04608982
68ROCK21.03602303
69ERBB41.00923198
70ICK0.99552743
71MINK10.98598314
72MAP3K120.97930943
73CDC42BPA0.97310489
74STK38L0.95726242
75PRKD10.95058937
76PRKCE0.93076368
77NME10.91958713
78MAP3K90.91895404
79PLK10.89016676
80CAMK2G0.88263735
81FRK0.88088634
82SGK20.87996858
83EPHA30.85624957
84LATS10.85275633
85NTRK10.83559131
86DAPK20.83525179
87PRKCH0.83457973
88CSNK1G10.82318254
89SRPK10.82223293
90PBK0.80259083
91TYRO30.80093026
92ZAK0.79513333
93MARK20.79301314
94NEK60.78883987
95CAMK10.77881882
96FGFR10.77551729
97DYRK20.72719003
98IRAK20.72547800
99LIMK10.71159157
100ROCK10.70269877
101PDK20.69039184
102TIE10.67953724
103STK110.67805915
104SGK10.67648510
105LATS20.67555994
106DYRK1A0.67059286
107CSNK1G20.66394350
108SGK30.65983806
109CSNK1A1L0.65260198
110MAP2K40.64436152
111BRSK20.63838076
112KSR10.63014549
113CAMK40.62524710
114PRKG10.59838257
115PLK20.59024968
116PTK20.58603338
117FER0.57669473
118PRKACA0.57513212
119CSNK1G30.57151914
120STK380.56899962
121PRKCG0.56499755
122CAMK1G0.56350060
123PRKAA10.55067065
124MAPK120.54961114
125STK240.51468243
126MAP4K20.51168217
127VRK10.50487418
128PRKACB0.49883150
129CDK150.49507340
130CDK180.49112333
131CDK140.48465260
132EIF2AK20.47911802
133CSNK1D0.47874741
134PDPK10.46898586
135EPHB20.46234191
136FES0.44718263
137GRK50.44684731
138CDK11A0.44662228
139ATM0.43919853
140RPS6KA30.42881383
141PRKCI0.42453146
142NUAK10.42056750
143NEK20.41202249
144MAPKAPK50.41179589
145MAP3K70.40712194
146CSNK1E0.40590469
147SIK20.39307262

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042602.97007687
2Dilated cardiomyopathy_Homo sapiens_hsa054142.53154389
3Nicotine addiction_Homo sapiens_hsa050332.44502968
4Circadian entrainment_Homo sapiens_hsa047132.22156941
5GABAergic synapse_Homo sapiens_hsa047272.20399180
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.15071325
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12983874
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10048923
9Phototransduction_Homo sapiens_hsa047442.09640319
10Morphine addiction_Homo sapiens_hsa050322.08666068
11Olfactory transduction_Homo sapiens_hsa047402.07555560
12Glutamatergic synapse_Homo sapiens_hsa047242.07391273
13Oxidative phosphorylation_Homo sapiens_hsa001902.05143158
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99398597
15Parkinsons disease_Homo sapiens_hsa050121.90287379
16Mismatch repair_Homo sapiens_hsa034301.84510162
17Synaptic vesicle cycle_Homo sapiens_hsa047211.82449901
18Non-homologous end-joining_Homo sapiens_hsa034501.81925958
19Insulin secretion_Homo sapiens_hsa049111.77560469
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70853837
21Fanconi anemia pathway_Homo sapiens_hsa034601.70096925
22Taste transduction_Homo sapiens_hsa047421.67920085
23Oocyte meiosis_Homo sapiens_hsa041141.67535558
24Alzheimers disease_Homo sapiens_hsa050101.65608834
25Fatty acid elongation_Homo sapiens_hsa000621.62141877
26Cholinergic synapse_Homo sapiens_hsa047251.61278399
27Dopaminergic synapse_Homo sapiens_hsa047281.55674037
28Serotonergic synapse_Homo sapiens_hsa047261.55547643
29Long-term potentiation_Homo sapiens_hsa047201.50735819
30Amphetamine addiction_Homo sapiens_hsa050311.49872919
31Axon guidance_Homo sapiens_hsa043601.49400024
32Vitamin B6 metabolism_Homo sapiens_hsa007501.46604737
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42837357
34Cell cycle_Homo sapiens_hsa041101.42350299
35Gastric acid secretion_Homo sapiens_hsa049711.41208594
36Hippo signaling pathway_Homo sapiens_hsa043901.37129220
37Calcium signaling pathway_Homo sapiens_hsa040201.37009720
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36632815
39Oxytocin signaling pathway_Homo sapiens_hsa049211.33506557
40Salivary secretion_Homo sapiens_hsa049701.32666172
41Renin secretion_Homo sapiens_hsa049241.31464509
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31206834
43Protein export_Homo sapiens_hsa030601.29101535
44Cocaine addiction_Homo sapiens_hsa050301.28400295
45cAMP signaling pathway_Homo sapiens_hsa040241.27581310
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26176181
47Homologous recombination_Homo sapiens_hsa034401.23906849
48DNA replication_Homo sapiens_hsa030301.23030690
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21762159
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20814039
51Proteasome_Homo sapiens_hsa030501.20411702
52Type II diabetes mellitus_Homo sapiens_hsa049301.20197243
53Huntingtons disease_Homo sapiens_hsa050161.17900632
54Steroid biosynthesis_Homo sapiens_hsa001001.17815547
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17191777
56Long-term depression_Homo sapiens_hsa047301.13278543
57Propanoate metabolism_Homo sapiens_hsa006401.12979800
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12708427
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.10945892
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09870668
61Basal transcription factors_Homo sapiens_hsa030221.08602636
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04315840
63Gap junction_Homo sapiens_hsa045401.03285795
64Butanoate metabolism_Homo sapiens_hsa006501.00382457
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94478775
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94100055
67Ovarian steroidogenesis_Homo sapiens_hsa049130.94079851
68Collecting duct acid secretion_Homo sapiens_hsa049660.91562423
69Base excision repair_Homo sapiens_hsa034100.88868495
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88843072
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88605758
72RNA polymerase_Homo sapiens_hsa030200.87654053
73RNA transport_Homo sapiens_hsa030130.87466473
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87427341
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86470224
76RNA degradation_Homo sapiens_hsa030180.86100763
77GnRH signaling pathway_Homo sapiens_hsa049120.85878962
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85286554
79ErbB signaling pathway_Homo sapiens_hsa040120.81836614
80Fatty acid metabolism_Homo sapiens_hsa012120.80849373
81Dorso-ventral axis formation_Homo sapiens_hsa043200.80175308
82Renal cell carcinoma_Homo sapiens_hsa052110.79258345
83Basal cell carcinoma_Homo sapiens_hsa052170.77950878
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77469040
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74378123
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72765768
87Ether lipid metabolism_Homo sapiens_hsa005650.72456140
88Nucleotide excision repair_Homo sapiens_hsa034200.72433105
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72012034
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.69564249
91Pancreatic secretion_Homo sapiens_hsa049720.69249927
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69119568
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68876654
94Melanogenesis_Homo sapiens_hsa049160.68449396
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67180891
96Ras signaling pathway_Homo sapiens_hsa040140.66815576
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65758579
98Nitrogen metabolism_Homo sapiens_hsa009100.65501334
99Adherens junction_Homo sapiens_hsa045200.64877671
100Estrogen signaling pathway_Homo sapiens_hsa049150.64666447
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64559132
102Vibrio cholerae infection_Homo sapiens_hsa051100.63637733
103MAPK signaling pathway_Homo sapiens_hsa040100.63135597
104Tight junction_Homo sapiens_hsa045300.63095555
105Selenocompound metabolism_Homo sapiens_hsa004500.62325116
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61657974
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59300206
108Thyroid hormone synthesis_Homo sapiens_hsa049180.57930523
109TGF-beta signaling pathway_Homo sapiens_hsa043500.57502896
110Circadian rhythm_Homo sapiens_hsa047100.56932934
111Inositol phosphate metabolism_Homo sapiens_hsa005620.55819039
112p53 signaling pathway_Homo sapiens_hsa041150.54259150
113Alcoholism_Homo sapiens_hsa050340.51695765
114Bile secretion_Homo sapiens_hsa049760.51590579
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50528354
116mRNA surveillance pathway_Homo sapiens_hsa030150.49259555
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48466724
118Fatty acid degradation_Homo sapiens_hsa000710.48078170
119Glucagon signaling pathway_Homo sapiens_hsa049220.47884287
120MicroRNAs in cancer_Homo sapiens_hsa052060.46762090
121Purine metabolism_Homo sapiens_hsa002300.46739826
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46343173
123Wnt signaling pathway_Homo sapiens_hsa043100.46303755
124Melanoma_Homo sapiens_hsa052180.44855387
125Choline metabolism in cancer_Homo sapiens_hsa052310.44543644
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44144094
127Viral myocarditis_Homo sapiens_hsa054160.44071473
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43323209
129Insulin signaling pathway_Homo sapiens_hsa049100.42422493
130Glioma_Homo sapiens_hsa052140.40882546
131Rap1 signaling pathway_Homo sapiens_hsa040150.38561324
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37482662
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.37454014
134Pyruvate metabolism_Homo sapiens_hsa006200.36250175
135Hedgehog signaling pathway_Homo sapiens_hsa043400.35868353
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34995281
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34031888
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32467690
139Fatty acid biosynthesis_Homo sapiens_hsa000610.31799931
140Endocytosis_Homo sapiens_hsa041440.30906621
141Carbon metabolism_Homo sapiens_hsa012000.30516830

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