FRMD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.42268877
2axon ensheathment in central nervous system (GO:0032291)7.42268877
3fatty acid elongation (GO:0030497)4.96374087
4myelin maintenance (GO:0043217)4.58105785
5axon ensheathment (GO:0008366)4.54317447
6ensheathment of neurons (GO:0007272)4.54317447
7leukocyte aggregation (GO:0070486)4.52974350
8positive regulation of gamma-delta T cell activation (GO:0046645)4.45940809
9myelination (GO:0042552)4.44605204
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39237049
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39237049
12amyloid precursor protein metabolic process (GO:0042982)4.18070645
13regulation of gamma-delta T cell differentiation (GO:0045586)4.07811469
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93915948
15T cell migration (GO:0072678)3.92492132
16creatine metabolic process (GO:0006600)3.84427976
17negative T cell selection (GO:0043383)3.79775931
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75757658
19mast cell activation (GO:0045576)3.73232808
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72334197
21negative thymic T cell selection (GO:0045060)3.66165528
22amyloid precursor protein catabolic process (GO:0042987)3.64850240
23regulation of gamma-delta T cell activation (GO:0046643)3.64794131
24antigen processing and presentation of endogenous antigen (GO:0019883)3.64692589
25regulation of interferon-beta biosynthetic process (GO:0045357)3.56950360
26cholesterol biosynthetic process (GO:0006695)3.40295679
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32486399
28negative regulation of cell killing (GO:0031342)3.32486399
29interferon-gamma production (GO:0032609)3.30768614
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.21181464
31modulation by symbiont of host immune response (GO:0052553)3.21181464
32positive regulation by symbiont of host defense response (GO:0052509)3.21181464
33modulation by symbiont of host defense response (GO:0052031)3.21181464
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21181464
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21181464
36positive thymic T cell selection (GO:0045059)3.20737522
37response to type I interferon (GO:0034340)3.19801145
38T cell receptor signaling pathway (GO:0050852)3.18735978
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17190175
40cellular response to type I interferon (GO:0071357)3.17159903
41type I interferon signaling pathway (GO:0060337)3.17159903
42response to lipoprotein particle (GO:0055094)3.13693796
43hemidesmosome assembly (GO:0031581)3.13212624
44membrane raft organization (GO:0031579)3.12726862
45positive regulation of interleukin-2 production (GO:0032743)3.11171133
46mast cell activation involved in immune response (GO:0002279)3.09017240
47mast cell degranulation (GO:0043303)3.09017240
48sterol biosynthetic process (GO:0016126)3.07174996
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.06383555
50detection of other organism (GO:0098543)3.05277916
51thymic T cell selection (GO:0045061)3.04864888
52detection of bacterium (GO:0016045)3.03221819
53activated T cell proliferation (GO:0050798)3.01947472
54long-chain fatty acid biosynthetic process (GO:0042759)2.96729255
55regulation of interleukin-2 biosynthetic process (GO:0045076)2.95649362
56response to interleukin-15 (GO:0070672)2.95523096
57neutrophil activation involved in immune response (GO:0002283)2.94372875
58positive regulation of histone deacetylation (GO:0031065)2.93531891
59positive regulation of interleukin-4 production (GO:0032753)2.91536430
60mannose metabolic process (GO:0006013)2.91430639
61response to peptidoglycan (GO:0032494)2.91343635
62macrophage activation involved in immune response (GO:0002281)2.90959251
63immunoglobulin mediated immune response (GO:0016064)2.88166076
64germinal center formation (GO:0002467)2.85281114
65angiogenesis involved in wound healing (GO:0060055)2.84679343
66positive regulation of pseudopodium assembly (GO:0031274)2.81917463
67antigen receptor-mediated signaling pathway (GO:0050851)2.81304799
68NIK/NF-kappaB signaling (GO:0038061)2.79654891
69T cell costimulation (GO:0031295)2.79495157
70T cell selection (GO:0045058)2.78954888
71positive regulation of interleukin-17 production (GO:0032740)2.78600158
72regulation of interleukin-13 production (GO:0032656)2.77674062
73T cell homeostasis (GO:0043029)2.77614453
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76531474
75membrane tubulation (GO:0097320)2.76200895
76GPI anchor biosynthetic process (GO:0006506)2.76154920
77lymphocyte costimulation (GO:0031294)2.74888719
78negative regulation of phagocytosis (GO:0050765)2.74484453
79regulation of B cell apoptotic process (GO:0002902)2.74382355
80positive regulation of gliogenesis (GO:0014015)2.73883734
81response to laminar fluid shear stress (GO:0034616)2.73839270
82oligodendrocyte differentiation (GO:0048709)2.73209348
83leukocyte degranulation (GO:0043299)2.72795073
84membrane protein ectodomain proteolysis (GO:0006509)2.71702075
85mature B cell differentiation involved in immune response (GO:0002313)2.71379109
86negative regulation of interleukin-12 production (GO:0032695)2.71247704
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69569731
88regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68633636
89regulation of interleukin-12 biosynthetic process (GO:0045075)2.68592966
90cellular response to interleukin-15 (GO:0071350)2.67549558
91regulation of B cell receptor signaling pathway (GO:0050855)2.66401877
92protein localization to endosome (GO:0036010)2.66211204
93positive regulation of tolerance induction (GO:0002645)2.65754026
94positive T cell selection (GO:0043368)2.65273288
95negative regulation of erythrocyte differentiation (GO:0045647)2.65051263
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.64919961
97regulation of isotype switching to IgG isotypes (GO:0048302)2.64623447
98regulation of T cell tolerance induction (GO:0002664)2.63762387
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.63041932
100adhesion of symbiont to host cell (GO:0044650)2.62893697
101virion attachment to host cell (GO:0019062)2.62893697
102lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62700023
103cortical actin cytoskeleton organization (GO:0030866)2.60680906
104leukocyte migration involved in inflammatory response (GO:0002523)2.59586159
105antigen processing and presentation via MHC class Ib (GO:0002475)2.59463042
106regulation of collateral sprouting (GO:0048670)2.58112104
107positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.57129023
108positive regulation of natural killer cell mediated immunity (GO:0002717)2.57129023
109tolerance induction (GO:0002507)2.56640611
110regulation of natural killer cell mediated immunity (GO:0002715)2.55814249
111regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55814249
112positive regulation of interferon-alpha production (GO:0032727)2.55433619
113regulation of T cell receptor signaling pathway (GO:0050856)2.54135730
114positive regulation of T cell cytokine production (GO:0002726)2.53460187
115detection of external biotic stimulus (GO:0098581)2.52141000
116regulation of interferon-alpha production (GO:0032647)2.51907407
117positive regulation of glial cell differentiation (GO:0045687)2.51720034
118B cell receptor signaling pathway (GO:0050853)2.51670849
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.51408802
120leukocyte homeostasis (GO:0001776)2.50331535
121mitotic nuclear envelope reassembly (GO:0007084)2.50032471
122nuclear envelope reassembly (GO:0031468)2.50032471
123endothelium development (GO:0003158)2.49612226
124isoprenoid biosynthetic process (GO:0008299)2.48761200
125negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48110356
126positive regulation of T cell mediated cytotoxicity (GO:0001916)2.47141925
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.45588543
128desmosome organization (GO:0002934)2.44822377
129leukocyte cell-cell adhesion (GO:0007159)2.44532915
130low-density lipoprotein particle clearance (GO:0034383)2.44027213
131respiratory burst (GO:0045730)2.43790709
132positive regulation of protein deacetylation (GO:0090312)2.43738137
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43500669
134heterotypic cell-cell adhesion (GO:0034113)2.43468421
135negative regulation of neurotransmitter secretion (GO:0046929)2.43090674
136negative regulation of interleukin-6 production (GO:0032715)2.42452847
137regulation of pseudopodium assembly (GO:0031272)2.42376359
138preassembly of GPI anchor in ER membrane (GO:0016254)2.42224251
139membrane protein intracellular domain proteolysis (GO:0031293)2.42187362
140viral transcription (GO:0019083)2.41650294
141regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.41487310
142regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40926306
143negative regulation of innate immune response (GO:0045824)2.39263943
144regulation of tolerance induction (GO:0002643)2.38972531
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38483933
146regulation of alpha-beta T cell proliferation (GO:0046640)2.37974868
147regulation of extracellular matrix disassembly (GO:0010715)2.35337388
148negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.34868678
149cellular extravasation (GO:0045123)2.34642953
150regulation of mast cell degranulation (GO:0043304)2.34610390
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34436099
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32583436
153response to host (GO:0075136)2.32583436
154response to host defenses (GO:0052200)2.32583436
155chaperone mediated protein folding requiring cofactor (GO:0051085)2.31679780
156defense response to protozoan (GO:0042832)2.31528655
157response to protozoan (GO:0001562)2.31449038
158negative regulation of tumor necrosis factor production (GO:0032720)2.30839114
159negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.30535188
160negative regulation of viral release from host cell (GO:1902187)2.29975153
161interferon-gamma-mediated signaling pathway (GO:0060333)2.29927973
162response to muramyl dipeptide (GO:0032495)2.26754246
163positive regulation of NF-kappaB import into nucleus (GO:0042346)2.25171218
164neutrophil activation (GO:0042119)2.24663541
165regulation of leukocyte degranulation (GO:0043300)2.24240289
166regulation of T cell mediated cytotoxicity (GO:0001914)2.23919806
167response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23885053
168response to host immune response (GO:0052572)2.23885053
169negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.23572523
170negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.22714368
171regulation of B cell differentiation (GO:0045577)2.22673962
172positive regulation of isotype switching (GO:0045830)2.21305796
173negative regulation of interleukin-8 production (GO:0032717)2.21136019
174regulation of T-helper 2 cell differentiation (GO:0045628)2.20918723
175negative regulation of T-helper cell differentiation (GO:0045623)2.19913619
176negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.19913619
177positive regulation of natural killer cell differentiation (GO:0032825)2.19784947
178granulocyte activation (GO:0036230)2.17400401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06781574
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.38668567
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94199534
4SCL_19346495_ChIP-Seq_HPC-7_Human2.91360015
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88335119
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.84258974
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.81788206
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79624261
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75421656
10VDR_21846776_ChIP-Seq_THP-1_Human2.69813521
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50365221
12RUNX_20019798_ChIP-Seq_JUKART_Human2.48750081
13MYC_22102868_ChIP-Seq_BL_Human2.40825808
14MYB_26560356_Chip-Seq_TH2_Human2.37896272
15MAF_26560356_Chip-Seq_TH1_Human2.36019819
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34544585
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29694296
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24886436
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12833384
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11572571
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.11193462
22UTX_26944678_Chip-Seq_JUKART_Human2.05497376
23VDR_24763502_ChIP-Seq_THP-1_Human2.05382431
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05110221
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.03932431
26* LXR_22292898_ChIP-Seq_THP-1_Human2.03816011
27* SPI1_23547873_ChIP-Seq_NB4_Human2.02476839
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00839805
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99517506
30* MYB_26560356_Chip-Seq_TH1_Human1.97974227
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.97743285
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95622920
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91850219
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88178615
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78186164
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77449864
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.77055394
38MAF_26560356_Chip-Seq_TH2_Human1.74477875
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71995615
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70402848
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67074764
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63212583
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58899010
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58384508
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58071824
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55691050
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52449738
48TCF7_22412390_ChIP-Seq_EML_Mouse1.51408220
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50824990
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49102887
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47469956
52E2F7_22180533_ChIP-Seq_HELA_Human1.42145277
53KDM2B_26808549_Chip-Seq_DND41_Human1.41819102
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39688348
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39154424
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37436076
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35588420
58ZNF263_19887448_ChIP-Seq_K562_Human1.31956972
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31823319
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30610807
61* SPI1_23127762_ChIP-Seq_K562_Human1.30127719
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.29532673
63GATA3_27048872_Chip-Seq_THYMUS_Human1.29307665
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29186539
65* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28799748
66BCL6_27268052_Chip-Seq_Bcells_Human1.28533722
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28066559
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26569799
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26381991
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26352656
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.25537832
72* P68_20966046_ChIP-Seq_HELA_Human1.23162824
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22041394
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20647325
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19424443
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19106069
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17677054
78ATF3_27146783_Chip-Seq_COLON_Human1.16904846
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16688934
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15951710
81* TP53_22127205_ChIP-Seq_IMR90_Human1.14510368
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12293164
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.12260729
84VDR_23849224_ChIP-Seq_CD4+_Human1.11628328
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09378906
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08863013
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.08826113
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08523443
89* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08470513
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08409992
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07767271
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06784036
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.06468710
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06060399
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05628517
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05042033
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05024659
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04875526
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02409494
100* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02225005
101* RXR_22158963_ChIP-Seq_LIVER_Mouse1.02053843
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.01911106
103* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00956357
104* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00956357
105* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00912007
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00870896
107PU_27001747_Chip-Seq_BMDM_Mouse0.99920040
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99419085
109XRN2_22483619_ChIP-Seq_HELA_Human0.99006551
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97543992
111GATA1_19941826_ChIP-Seq_K562_Human0.96113165
112TP63_17297297_ChIP-ChIP_HaCaT_Human0.95260217
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94504422
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94401664
115NCOR1_26117541_ChIP-Seq_K562_Human0.93707104
116GATA3_26560356_Chip-Seq_TH2_Human0.93676271
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93519298
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93068622
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92444716
120GABP_17652178_ChIP-ChIP_JURKAT_Human0.91965133
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.90817510
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88702162
123TFEB_21752829_ChIP-Seq_HELA_Human0.88004523
124CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87642921
125FOXP3_21729870_ChIP-Seq_TREG_Human0.85706539
126EST1_17652178_ChIP-ChIP_JURKAT_Human0.84923706
127* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84313749
128STAT1_20625510_ChIP-Seq_HELA_Human0.84024409
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.83124676
130BCOR_27268052_Chip-Seq_Bcells_Human0.83017309
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81646587
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79695663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.72195060
2MP0003763_abnormal_thymus_physiology3.23215457
3MP0000685_abnormal_immune_system3.08567167
4MP0005671_abnormal_response_to2.87862092
5MP0010234_abnormal_vibrissa_follicle2.77802902
6MP0006082_CNS_inflammation2.70057518
7MP0003950_abnormal_plasma_membrane2.67708800
8MP0009333_abnormal_splenocyte_physiolog2.43383317
9MP0005000_abnormal_immune_tolerance2.40479433
10MP0001790_abnormal_immune_system2.36803094
11MP0005387_immune_system_phenotype2.36803094
12MP0001800_abnormal_humoral_immune2.31776715
13MP0002723_abnormal_immune_serum2.31771626
14MP0009785_altered_susceptibility_to2.31311428
15MP0001835_abnormal_antigen_presentation2.29722917
16MP0002420_abnormal_adaptive_immunity2.26307317
17MP0005025_abnormal_response_to2.24927517
18MP0001819_abnormal_immune_cell2.23841291
19MP0002452_abnormal_antigen_presenting2.19237248
20MP0000465_gastrointestinal_hemorrhage2.15693602
21MP0009840_abnormal_foam_cell2.10876305
22MP0002398_abnormal_bone_marrow2.07599812
23MP0004381_abnormal_hair_follicle2.03792343
24MP0002419_abnormal_innate_immunity2.03249271
25MP0002396_abnormal_hematopoietic_system2.02475463
26MP0000716_abnormal_immune_system1.98637713
27MP0002254_reproductive_system_inflammat1.98035016
28MP0003724_increased_susceptibility_to1.96878293
29MP0003436_decreased_susceptibility_to1.95055074
30MP0002405_respiratory_system_inflammati1.94420609
31MP0005058_abnormal_lysosome_morphology1.91410873
32MP0005464_abnormal_platelet_physiology1.90437662
33MP0002933_joint_inflammation1.89353019
34MP0002148_abnormal_hypersensitivity_rea1.87672398
35MP0000689_abnormal_spleen_morphology1.78027780
36MP0010155_abnormal_intestine_physiology1.75991461
37MP0002722_abnormal_immune_system1.73568544
38MP0005451_abnormal_body_composition1.71138708
39MP0001851_eye_inflammation1.68536965
40MP0002429_abnormal_blood_cell1.67185384
41MP0000703_abnormal_thymus_morphology1.63168824
42MP0003705_abnormal_hypodermis_morpholog1.60606398
43MP0004947_skin_inflammation1.57088243
44MP0003690_abnormal_glial_cell1.56274651
45MP0003279_aneurysm1.55191986
46MP0002796_impaired_skin_barrier1.55054931
47MP0009278_abnormal_bone_marrow1.50937475
48MP0003866_abnormal_defecation1.47156059
49MP0005075_abnormal_melanosome_morpholog1.45191687
50MP0001873_stomach_inflammation1.40676870
51MP0003566_abnormal_cell_adhesion1.40025154
52MP0003828_pulmonary_edema1.38304215
53MP0002060_abnormal_skin_morphology1.35572951
54MP0003300_gastrointestinal_ulcer1.34780058
55MP0000383_abnormal_hair_follicle1.33465998
56MP0000015_abnormal_ear_pigmentation1.33163445
57MP0001348_abnormal_lacrimal_gland1.31242850
58MP0003303_peritoneal_inflammation1.29426751
59MP0002877_abnormal_melanocyte_morpholog1.28706787
60MP0005501_abnormal_skin_physiology1.28393763
61MP0004808_abnormal_hematopoietic_stem1.26397261
62MP0001845_abnormal_inflammatory_respons1.26144436
63MP0000490_abnormal_crypts_of1.24066573
64MP0001545_abnormal_hematopoietic_system1.21927891
65MP0005397_hematopoietic_system_phenotyp1.21927891
66MP0010678_abnormal_skin_adnexa1.21764691
67MP0001533_abnormal_skeleton_physiology1.20887822
68MP0004510_myositis1.18680024
69MP0003806_abnormal_nucleotide_metabolis1.18501732
70MP0001216_abnormal_epidermal_layer1.15529180
71MP0003448_altered_tumor_morphology1.14213594
72MP0003453_abnormal_keratinocyte_physiol1.12078074
73MP0002132_abnormal_respiratory_system1.11499791
74MP0005410_abnormal_fertilization1.11478876
75MP0005023_abnormal_wound_healing1.10720212
76MP0001853_heart_inflammation1.09142505
77MP0008057_abnormal_DNA_replication1.09009861
78MP0009764_decreased_sensitivity_to1.08978888
79MP0008004_abnormal_stomach_pH1.08656216
80MP0003045_fibrosis1.05302919
81MP0002138_abnormal_hepatobiliary_system1.05151173
82MP0008260_abnormal_autophagy1.03554836
83MP0005310_abnormal_salivary_gland0.99415234
84MP0005076_abnormal_cell_differentiation0.98448903
85MP0003634_abnormal_glial_cell0.97823970
86MP0009931_abnormal_skin_appearance0.97734729
87MP0000467_abnormal_esophagus_morphology0.96967454
88MP0003075_altered_response_to0.96795737
89MP0005164_abnormal_response_to0.96221200
90MP0003091_abnormal_cell_migration0.95710651
91MP0003136_yellow_coat_color0.94452174
92MP0005166_decreased_susceptibility_to0.93467477
93MP0002166_altered_tumor_susceptibility0.91725501
94MP0004883_abnormal_blood_vessel0.89596247
95MP0004134_abnormal_chest_morphology0.89453068
96MP0008438_abnormal_cutaneous_collagen0.88738151
97MP0000767_abnormal_smooth_muscle0.87479064
98MP0000733_abnormal_muscle_development0.86793247
99MP0003172_abnormal_lysosome_physiology0.84855152
100MP0009765_abnormal_xenobiotic_induced0.84670635
101MP0008469_abnormal_protein_level0.84669788
102MP0002019_abnormal_tumor_incidence0.84234190
103MP0006054_spinal_hemorrhage0.84064253
104MP0002998_abnormal_bone_remodeling0.82148103
105MP0000249_abnormal_blood_vessel0.81323290
106MP0003329_amyloid_beta_deposits0.81149424
107MP0004742_abnormal_vestibular_system0.80253126
108MP0005409_darkened_coat_color0.79863538
109MP0001958_emphysema0.79485694
110MP0000858_altered_metastatic_potential0.79365794
111MP0004272_abnormal_basement_membrane0.78352992
112MP0000604_amyloidosis0.78027257
113MP0003191_abnormal_cellular_cholesterol0.77212163
114MP0005623_abnormal_meninges_morphology0.77193054
115MP0002098_abnormal_vibrissa_morphology0.73822394
116MP0003077_abnormal_cell_cycle0.73467772
117MP0001243_abnormal_dermal_layer0.71191556
118MP0008873_increased_physiological_sensi0.70456649
119MP0003656_abnormal_erythrocyte_physiolo0.70417855
120MP0000477_abnormal_intestine_morphology0.70408140
121MP0005171_absent_coat_pigmentation0.69869214
122MP0004142_abnormal_muscle_tone0.68460610
123MP0009763_increased_sensitivity_to0.67867185
124MP0001849_ear_inflammation0.67520155
125MP0000377_abnormal_hair_follicle0.66191781
126MP0002006_tumorigenesis0.65359450
127MP0000343_altered_response_to0.65354910
128MP0005390_skeleton_phenotype0.64220437

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.08764730
2Elevated erythrocyte sedimentation rate (HP:0003565)4.53358810
3T lymphocytopenia (HP:0005403)4.15947934
4Cerebral hypomyelination (HP:0006808)3.99069916
5Abnormality of T cell number (HP:0011839)3.96743253
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.92293913
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.92293913
8Stomatitis (HP:0010280)3.85945391
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.70370772
10Orchitis (HP:0100796)3.58907800
11Peripheral hypomyelination (HP:0007182)3.57139447
12Neurofibrillary tangles (HP:0002185)3.40173650
13Parakeratosis (HP:0001036)3.38749945
14Hepatosplenomegaly (HP:0001433)3.31724822
15Sensory axonal neuropathy (HP:0003390)3.28910954
16Increased IgE level (HP:0003212)3.20754404
17IgM deficiency (HP:0002850)3.16368880
18Premature skin wrinkling (HP:0100678)3.14803914
19Severe combined immunodeficiency (HP:0004430)3.10470908
20Abnormality of macrophages (HP:0004311)3.10089006
21Optic neuritis (HP:0100653)3.08821810
22Retrobulbar optic neuritis (HP:0100654)3.08821810
23Nasal polyposis (HP:0100582)3.06698987
24Recurrent bronchitis (HP:0002837)2.97560745
25Onion bulb formation (HP:0003383)2.92989985
26Abnormality of T cells (HP:0002843)2.91383017
27Panhypogammaglobulinemia (HP:0003139)2.90641218
28Eczematoid dermatitis (HP:0000976)2.88594001
29Recurrent abscess formation (HP:0002722)2.87535605
30Recurrent viral infections (HP:0004429)2.86156065
31Recurrent fungal infections (HP:0002841)2.83500657
32Combined immunodeficiency (HP:0005387)2.83011492
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80599208
34Abnormality of the nasal mucosa (HP:0000433)2.77715600
35Stridor (HP:0010307)2.77592759
36Petechiae (HP:0000967)2.76565553
37Recurrent skin infections (HP:0001581)2.75320602
38Fragile skin (HP:0001030)2.73543665
39Purpura (HP:0000979)2.72712201
40Myositis (HP:0100614)2.72123047
41Premature loss of primary teeth (HP:0006323)2.71767396
42Leukocytosis (HP:0001974)2.71215305
43Abnormality of eosinophils (HP:0001879)2.68644623
44Peritonitis (HP:0002586)2.63764332
45Cellulitis (HP:0100658)2.63753040
46Pustule (HP:0200039)2.62516631
47Segmental peripheral demyelination/remyelination (HP:0003481)2.61544136
48Loss of speech (HP:0002371)2.60676105
49Abnormal auditory evoked potentials (HP:0006958)2.56372511
50Plantar hyperkeratosis (HP:0007556)2.54222116
51Hemorrhage of the eye (HP:0011885)2.53340897
52Spontaneous hematomas (HP:0007420)2.52036847
53Mediastinal lymphadenopathy (HP:0100721)2.50668894
54Gastrointestinal infarctions (HP:0005244)2.49962574
55IgG deficiency (HP:0004315)2.49791822
56Dysostosis multiplex (HP:0000943)2.49161127
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47860985
58Abnormality of polysaccharide metabolism (HP:0011012)2.47860985
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47860985
60Eosinophilia (HP:0001880)2.46020576
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.45706832
62Asplenia (HP:0001746)2.44112732
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.40888060
64Abnormality of glycolipid metabolism (HP:0010969)2.40888060
65Abnormality of liposaccharide metabolism (HP:0010968)2.40888060
66Slow saccadic eye movements (HP:0000514)2.35881169
67Milia (HP:0001056)2.33117385
68Recurrent bacterial skin infections (HP:0005406)2.31359205
69Hemoptysis (HP:0002105)2.31239414
70Recurrent cutaneous fungal infections (HP:0011370)2.31013687
71Chronic mucocutaneous candidiasis (HP:0002728)2.31013687
72Mucopolysacchariduria (HP:0008155)2.30572796
73Urinary glycosaminoglycan excretion (HP:0003541)2.30572796
74CNS hypomyelination (HP:0003429)2.30297326
75Obstructive lung disease (HP:0006536)2.29470219
76Chronic obstructive pulmonary disease (HP:0006510)2.29470219
77Urticaria (HP:0001025)2.28819917
78Pulmonary infiltrates (HP:0002113)2.28546911
79Atrophic scars (HP:0001075)2.28235095
80Congenital ichthyosiform erythroderma (HP:0007431)2.26390800
81Cerebral aneurysm (HP:0004944)2.25541288
82Verrucae (HP:0200043)2.23957927
83Papilloma (HP:0012740)2.23957927
84Lymphopenia (HP:0001888)2.22832690
85Abnormality of the corticospinal tract (HP:0002492)2.21854723
86Granulocytopenia (HP:0001913)2.21550970
87Vasculitis (HP:0002633)2.21311340
88Abnormality of T cell physiology (HP:0011840)2.20929656
89Thyroiditis (HP:0100646)2.20818328
90Keratoconjunctivitis sicca (HP:0001097)2.20372039
91Spastic paraparesis (HP:0002313)2.20176354
92Axonal loss (HP:0003447)2.19978456
93Gastrointestinal inflammation (HP:0004386)2.18973011
94Keratoconjunctivitis (HP:0001096)2.18690832
95Thick nail (HP:0001805)2.17816504
96Abnormal platelet volume (HP:0011876)2.16947145
97White forelock (HP:0002211)2.15562662
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.15423848
99Increased cerebral lipofuscin (HP:0011813)2.15350475
100Vacuolated lymphocytes (HP:0001922)2.15259692
101Aplasia/Hypoplasia of the spleen (HP:0010451)2.14670270
102Premature rupture of membranes (HP:0001788)2.13906233
103Chest pain (HP:0100749)2.10799532
104Gingivitis (HP:0000230)2.08055612
105Patchy hypopigmentation of hair (HP:0011365)2.06719328
106Fragile nails (HP:0001808)2.06584445
107Abnormal delayed hypersensitivity skin test (HP:0002963)2.06113226
108Abnormal blistering of the skin (HP:0008066)2.04972078
109Aplasia cutis congenita (HP:0001057)2.04773328
110Prolonged neonatal jaundice (HP:0006579)2.03320936
111Cerebral inclusion bodies (HP:0100314)2.03055517
112Hypergammaglobulinemia (HP:0010702)2.02919836
113Spondylolisthesis (HP:0003302)2.02900037
114Chronic diarrhea (HP:0002028)2.01824689
115Autoimmune hemolytic anemia (HP:0001890)2.00467246
116Progressive neurologic deterioration (HP:0002344)1.99739745
117Agammaglobulinemia (HP:0004432)1.98730243
118Osteomyelitis (HP:0002754)1.98705504
119Muscle fibrillation (HP:0010546)1.98606434
120Meningitis (HP:0001287)1.97725250
121Gastrointestinal stroma tumor (HP:0100723)1.96503351
122Episodic fever (HP:0001954)1.93931485
123Colitis (HP:0002583)1.93192996
124Hypertensive crisis (HP:0100735)1.93073745
125Nail dystrophy (HP:0008404)1.92800950
126Alopecia of scalp (HP:0002293)1.91647179
127Skin ulcer (HP:0200042)1.91629473
128Interstitial pulmonary disease (HP:0006530)1.88951349
129Ulnar bowing (HP:0003031)1.88771623
130Partial duplication of thumb phalanx (HP:0009944)1.87731660
131Increased IgM level (HP:0003496)1.87525080
132Esophageal atresia (HP:0002032)1.87488524
133B lymphocytopenia (HP:0010976)1.87472175
134Abnormality of B cell number (HP:0010975)1.87472175
135Encephalitis (HP:0002383)1.86735249
136Palmoplantar hyperkeratosis (HP:0000972)1.86513947
137Fatigue (HP:0012378)1.86103652
138Epistaxis (HP:0000421)1.85818868
139Increased mean platelet volume (HP:0011877)1.85623988
140Lymphoma (HP:0002665)1.85220695
141Increased serum ferritin (HP:0003281)1.84942207
142Joint stiffness (HP:0001387)1.84689468
143Morphological abnormality of the inner ear (HP:0011390)1.84595331
144Sepsis (HP:0100806)1.84510461
145Thrombocytosis (HP:0001894)1.83942923
146Cheilitis (HP:0100825)1.83829821
147Seborrheic dermatitis (HP:0001051)1.83429167
148Hematochezia (HP:0002573)1.82800493
149Arterial thrombosis (HP:0004420)1.82771557
150Prolonged bleeding time (HP:0003010)1.82266182
151Hypertriglyceridemia (HP:0002155)1.82071360
152Malnutrition (HP:0004395)1.80754417
153Paraparesis (HP:0002385)1.80153268
154Distal lower limb muscle weakness (HP:0009053)1.79244256
155Protrusio acetabuli (HP:0003179)1.79038205
156Osteolytic defects of the hand bones (HP:0009699)1.78928365
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.78928365
158Increased connective tissue (HP:0009025)1.78777229
159Inflammation of the large intestine (HP:0002037)1.78304103
160Gingival bleeding (HP:0000225)1.77766270
161Abnormality of the peritoneum (HP:0002585)1.77554236
162Thin bony cortex (HP:0002753)1.76874818
163Cervical subluxation (HP:0003308)1.75958484
164Erythroderma (HP:0001019)1.75827673
165J-shaped sella turcica (HP:0002680)1.75370368
166Emphysema (HP:0002097)1.75278839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.30092389
2MAP4K14.12632668
3ERN13.73496498
4STK393.26518395
5TESK23.21323879
6IRAK32.86359157
7STK102.52752127
8SIK12.49793053
9TXK2.49234315
10EPHA22.47790703
11MST1R2.45567679
12CLK12.38854775
13MAP3K32.36245411
14SMG12.31144176
15MST42.28275860
16EEF2K2.25282771
17TRIB32.18564936
18MAP2K32.03234019
19NME22.02169137
20BLK1.93865918
21JAK31.80511444
22ZAP701.79119682
23OXSR11.78678871
24MAPKAPK51.77553389
25TAOK21.77109494
26PKN11.67218023
27SIK31.63980563
28ITK1.63226996
29NLK1.61149201
30CDK191.56517008
31RIPK41.55613925
32BTK1.50599531
33TBK11.50512511
34KDR1.46008467
35TNK21.45895057
36IKBKE1.40686105
37LCK1.36433539
38IRAK41.33944315
39LIMK11.28754621
40LRRK21.28237537
41MAP2K61.27179801
42MET1.26171145
43KIT1.23464119
44PTK61.21023094
45MAP3K11.20038999
46PBK1.18927218
47BUB11.18121744
48TGFBR21.17606078
49ICK1.16163213
50IKBKB1.15256076
51CSK1.14349106
52TYK21.11646416
53MAP3K101.10019277
54MAPKAPK31.10010830
55TAOK11.09952341
56GRK61.09671061
57MAP3K141.07974619
58CSF1R1.07965223
59CSNK1G31.07953956
60RIPK11.05600503
61PKN21.00228663
62TRPM70.98486078
63RPS6KA50.98210096
64LMTK20.97459823
65CSNK1A1L0.96980072
66FER0.93426474
67TAOK30.92121444
68TIE10.91999800
69CSNK1G10.88735641
70ROCK20.87971178
71MAP3K130.86653031
72TEC0.86293008
73FGR0.84016723
74HCK0.83421944
75PRKCQ0.83195604
76PIM20.82784305
77MAP2K20.82047346
78PRKD20.81984941
79IRAK10.81166331
80FGFR20.80610932
81FGFR40.79951324
82MAP3K80.78553153
83TESK10.76512376
84MAP3K70.74613808
85PIM10.74581170
86RPS6KA40.71956694
87SYK0.70462939
88MARK20.68696943
89STK40.67436201
90TYRO30.66630067
91MAP3K110.66004975
92EPHB20.65854635
93CDC42BPA0.65153134
94BMX0.64884155
95PRKG20.64752940
96PTK2B0.63699840
97MAPK110.62430223
98PAK10.60607551
99PTK20.59899461
100UHMK10.59593482
101MAPKAPK20.59365829
102WNK40.58579766
103MARK30.57978991
104LYN0.57246349
105PRKD10.56335936
106PRKCI0.56127576
107FES0.55328256
108BCR0.52217509
109JAK10.51368016
110STK380.51230654
111MOS0.50707753
112TNIK0.49925969
113HIPK20.49918170
114MAP3K20.49804711
115CDK40.48371741
116MAPK120.48178450
117TLK10.47814234
118MAPK70.47344025
119DYRK30.47296614
120PAK40.47008803
121FGFR30.46523110
122PRKCH0.46426310
123MATK0.46062782
124IRAK20.45479545
125CAMK2B0.44988076
126NEK20.44455049
127JAK20.44113168
128STK240.43069588
129RPS6KL10.42590089
130RPS6KC10.42590089
131RPS6KA20.42041685
132PDGFRB0.40884442
133GSK3A0.39751898
134PDK10.38914571
135INSR0.38061897
136WNK10.35504690
137CSNK1G20.34946841
138PRPF4B0.34101876
139CHUK0.33950002
140FYN0.33864409
141PDPK10.32430010
142RPS6KB20.32379102
143PAK20.31706989
144MELK0.31342080

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.59645490
2Primary immunodeficiency_Homo sapiens_hsa053403.37423283
3Steroid biosynthesis_Homo sapiens_hsa001003.21612854
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.79302200
5Fatty acid elongation_Homo sapiens_hsa000622.50495397
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30842754
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.18070184
8T cell receptor signaling pathway_Homo sapiens_hsa046601.97515084
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92246464
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.85355455
11Ether lipid metabolism_Homo sapiens_hsa005651.79922696
12Ribosome_Homo sapiens_hsa030101.74046835
13Measles_Homo sapiens_hsa051621.72735068
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68867958
15B cell receptor signaling pathway_Homo sapiens_hsa046621.64691156
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.60906262
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56309779
18Shigellosis_Homo sapiens_hsa051311.56010039
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.56005575
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53460058
21Hematopoietic cell lineage_Homo sapiens_hsa046401.47115769
22Tuberculosis_Homo sapiens_hsa051521.43347114
23Leishmaniasis_Homo sapiens_hsa051401.42186820
24Type I diabetes mellitus_Homo sapiens_hsa049401.41603697
25Osteoclast differentiation_Homo sapiens_hsa043801.40225867
26Malaria_Homo sapiens_hsa051441.39878847
27Antigen processing and presentation_Homo sapiens_hsa046121.36422592
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36237200
29Vitamin B6 metabolism_Homo sapiens_hsa007501.35761175
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34889516
31DNA replication_Homo sapiens_hsa030301.33372511
32Allograft rejection_Homo sapiens_hsa053301.32949643
33Sphingolipid metabolism_Homo sapiens_hsa006001.29821625
34Graft-versus-host disease_Homo sapiens_hsa053321.27545019
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.18863798
36Folate biosynthesis_Homo sapiens_hsa007901.18693002
37Staphylococcus aureus infection_Homo sapiens_hsa051501.14848722
38Autoimmune thyroid disease_Homo sapiens_hsa053201.10084696
39Acute myeloid leukemia_Homo sapiens_hsa052211.09017221
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06058307
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02211885
42Protein export_Homo sapiens_hsa030601.01925879
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01505721
44Chemokine signaling pathway_Homo sapiens_hsa040621.01333179
45African trypanosomiasis_Homo sapiens_hsa051431.00838582
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00193273
47Sulfur relay system_Homo sapiens_hsa041220.99508208
48Sphingolipid signaling pathway_Homo sapiens_hsa040710.98046881
49Bladder cancer_Homo sapiens_hsa052190.97367455
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95880307
51Salmonella infection_Homo sapiens_hsa051320.94661006
52Non-homologous end-joining_Homo sapiens_hsa034500.94173886
53Platelet activation_Homo sapiens_hsa046110.91348894
54Renal cell carcinoma_Homo sapiens_hsa052110.90887045
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90314118
56Toxoplasmosis_Homo sapiens_hsa051450.89576949
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89358155
58Herpes simplex infection_Homo sapiens_hsa051680.88406398
59Lysosome_Homo sapiens_hsa041420.87860946
60Other glycan degradation_Homo sapiens_hsa005110.87438848
61Non-small cell lung cancer_Homo sapiens_hsa052230.87050633
62Apoptosis_Homo sapiens_hsa042100.86970525
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86774010
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.86717070
65Mismatch repair_Homo sapiens_hsa034300.85677834
66Pancreatic cancer_Homo sapiens_hsa052120.84882793
67Caffeine metabolism_Homo sapiens_hsa002320.83667930
68Endocytosis_Homo sapiens_hsa041440.83193901
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83160036
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83135327
71Fructose and mannose metabolism_Homo sapiens_hsa000510.82807472
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82494556
73Viral carcinogenesis_Homo sapiens_hsa052030.81033687
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79331358
75Viral myocarditis_Homo sapiens_hsa054160.79181841
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79050502
77Proteasome_Homo sapiens_hsa030500.78056555
78Chronic myeloid leukemia_Homo sapiens_hsa052200.77570176
79Pertussis_Homo sapiens_hsa051330.76851166
80Insulin resistance_Homo sapiens_hsa049310.76214232
81Spliceosome_Homo sapiens_hsa030400.75958432
82Base excision repair_Homo sapiens_hsa034100.75514989
83Linoleic acid metabolism_Homo sapiens_hsa005910.75307128
84RNA polymerase_Homo sapiens_hsa030200.74695139
85Hepatitis B_Homo sapiens_hsa051610.74636193
86Asthma_Homo sapiens_hsa053100.74535845
87Phagosome_Homo sapiens_hsa041450.74482060
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74374487
89Histidine metabolism_Homo sapiens_hsa003400.73114088
90Small cell lung cancer_Homo sapiens_hsa052220.72022584
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71480996
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.70666652
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70509161
94Hepatitis C_Homo sapiens_hsa051600.69374940
95Focal adhesion_Homo sapiens_hsa045100.69128155
96ECM-receptor interaction_Homo sapiens_hsa045120.68535131
97Epstein-Barr virus infection_Homo sapiens_hsa051690.68399226
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68140216
99Galactose metabolism_Homo sapiens_hsa000520.66187416
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65347162
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64595182
102Amoebiasis_Homo sapiens_hsa051460.63050951
103HTLV-I infection_Homo sapiens_hsa051660.62709624
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.61745280
105Inositol phosphate metabolism_Homo sapiens_hsa005620.60500007
106TNF signaling pathway_Homo sapiens_hsa046680.58931134
107p53 signaling pathway_Homo sapiens_hsa041150.57359482
108Nucleotide excision repair_Homo sapiens_hsa034200.57303961
109N-Glycan biosynthesis_Homo sapiens_hsa005100.57133262
110Arachidonic acid metabolism_Homo sapiens_hsa005900.56145855
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.54520780
112mTOR signaling pathway_Homo sapiens_hsa041500.53837840
113Prolactin signaling pathway_Homo sapiens_hsa049170.53714334
114Homologous recombination_Homo sapiens_hsa034400.53293298
115Rheumatoid arthritis_Homo sapiens_hsa053230.52502358
116VEGF signaling pathway_Homo sapiens_hsa043700.51974472
117Glutathione metabolism_Homo sapiens_hsa004800.51792233
118Notch signaling pathway_Homo sapiens_hsa043300.50679729
119Legionellosis_Homo sapiens_hsa051340.50601179
120Basal transcription factors_Homo sapiens_hsa030220.50135815
121Endometrial cancer_Homo sapiens_hsa052130.50022343
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.49672107
123Prostate cancer_Homo sapiens_hsa052150.49064394
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48839046
125Sulfur metabolism_Homo sapiens_hsa009200.48430871
126Proteoglycans in cancer_Homo sapiens_hsa052050.48347844
127Dorso-ventral axis formation_Homo sapiens_hsa043200.45821245
128Influenza A_Homo sapiens_hsa051640.45810696
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.45435156
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43916321
131Pentose phosphate pathway_Homo sapiens_hsa000300.43269883
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42563890
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42516116
134Vitamin digestion and absorption_Homo sapiens_hsa049770.41736378

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