FRMPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)8.01174585
2photoreceptor cell development (GO:0042461)6.46280766
3photoreceptor cell maintenance (GO:0045494)6.29686051
4detection of light stimulus involved in sensory perception (GO:0050962)6.17889195
5detection of light stimulus involved in visual perception (GO:0050908)6.17889195
6GMP metabolic process (GO:0046037)6.13728265
7eye photoreceptor cell development (GO:0042462)6.12391173
8behavioral response to nicotine (GO:0035095)6.11449746
9positive regulation of guanylate cyclase activity (GO:0031284)5.99463536
10phototransduction (GO:0007602)5.77807082
11retinal rod cell development (GO:0046548)5.76900175
12phototransduction, visible light (GO:0007603)5.75498353
13regulation of guanylate cyclase activity (GO:0031282)5.71029993
14detection of visible light (GO:0009584)5.55298476
15detection of light stimulus (GO:0009583)5.51349719
16protein-chromophore linkage (GO:0018298)5.38444201
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.86307077
18visual perception (GO:0007601)4.67746644
19sensory perception of light stimulus (GO:0050953)4.62005080
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61814033
21cellular potassium ion homeostasis (GO:0030007)4.54696096
22sodium ion export (GO:0071436)4.50403154
23cellular response to light stimulus (GO:0071482)4.36777771
24synaptic vesicle maturation (GO:0016188)4.29510469
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.26939633
26detection of external stimulus (GO:0009581)4.26353909
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.22893610
28detection of abiotic stimulus (GO:0009582)4.17736335
29fucose catabolic process (GO:0019317)4.16417664
30L-fucose metabolic process (GO:0042354)4.16417664
31L-fucose catabolic process (GO:0042355)4.16417664
32eye photoreceptor cell differentiation (GO:0001754)4.14992916
33photoreceptor cell differentiation (GO:0046530)4.14992916
34retina development in camera-type eye (GO:0060041)4.09829366
35regulation of cGMP metabolic process (GO:0030823)3.95536993
36kynurenine metabolic process (GO:0070189)3.85150428
37cell migration in hindbrain (GO:0021535)3.81248142
38protein localization to synapse (GO:0035418)3.78601242
39CDP-diacylglycerol metabolic process (GO:0046341)3.75021102
40glutamate secretion (GO:0014047)3.74829438
41gamma-aminobutyric acid transport (GO:0015812)3.74479060
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70592757
43tryptophan catabolic process (GO:0006569)3.68664541
44indole-containing compound catabolic process (GO:0042436)3.68664541
45indolalkylamine catabolic process (GO:0046218)3.68664541
46CDP-diacylglycerol biosynthetic process (GO:0016024)3.67285052
47detection of temperature stimulus (GO:0016048)3.66045286
48neurofilament cytoskeleton organization (GO:0060052)3.64043321
49regulation of clathrin-mediated endocytosis (GO:2000369)3.62818204
50positive regulation of cGMP biosynthetic process (GO:0030828)3.57396201
51regulation of cGMP biosynthetic process (GO:0030826)3.53468333
52positive regulation of sodium ion transmembrane transport (GO:1902307)3.51522914
53response to pheromone (GO:0019236)3.48845736
54pyrimidine nucleobase catabolic process (GO:0006208)3.48807991
55neuronal action potential (GO:0019228)3.46207428
56regulation of synaptic vesicle exocytosis (GO:2000300)3.44878615
57innervation (GO:0060384)3.44252975
58synaptic vesicle docking involved in exocytosis (GO:0016081)3.44204465
59regulation of voltage-gated calcium channel activity (GO:1901385)3.43620431
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43577729
61synaptic vesicle exocytosis (GO:0016079)3.42554605
62indolalkylamine metabolic process (GO:0006586)3.41630272
63potassium ion homeostasis (GO:0055075)3.40749142
64DNA deamination (GO:0045006)3.39369496
65proline transport (GO:0015824)3.39140238
66detection of temperature stimulus involved in sensory perception (GO:0050961)3.32525878
67detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.32525878
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28191628
69positive regulation of cGMP metabolic process (GO:0030825)3.27043967
70negative regulation of telomere maintenance (GO:0032205)3.26175326
71cell communication by electrical coupling (GO:0010644)3.21801924
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18755405
73regulation of action potential (GO:0098900)3.18716063
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18057796
75kidney morphogenesis (GO:0060993)3.17249473
76primary amino compound metabolic process (GO:1901160)3.17216038
77serotonin metabolic process (GO:0042428)3.16458624
78locomotory exploration behavior (GO:0035641)3.15962150
79tryptophan metabolic process (GO:0006568)3.14646630
80neuromuscular process controlling posture (GO:0050884)3.14116786
81indole-containing compound metabolic process (GO:0042430)3.13430611
82chemosensory behavior (GO:0007635)3.12522090
83mitochondrion transport along microtubule (GO:0047497)3.11978519
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11978519
85behavioral response to ethanol (GO:0048149)3.11921693
86piRNA metabolic process (GO:0034587)3.10918383
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.09536891
88ATP synthesis coupled proton transport (GO:0015986)3.08973135
89energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08973135
90synaptic transmission, cholinergic (GO:0007271)3.07657705
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06195507
92layer formation in cerebral cortex (GO:0021819)3.04161852
93cellular ketone body metabolic process (GO:0046950)3.03264456
94regulation of synaptic vesicle transport (GO:1902803)3.02823042
95protein-cofactor linkage (GO:0018065)3.02796356
96positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.01509105
97nephron tubule morphogenesis (GO:0072078)3.00515543
98nephron epithelium morphogenesis (GO:0072088)3.00515543
99water-soluble vitamin biosynthetic process (GO:0042364)2.99493278
100receptor guanylyl cyclase signaling pathway (GO:0007168)2.97235380
101phosphatidylinositol acyl-chain remodeling (GO:0036149)2.96772918
102reflex (GO:0060004)2.96264793
103membrane repolarization (GO:0086009)2.96173625
104positive regulation of potassium ion transmembrane transport (GO:1901381)2.95242607
105nucleobase catabolic process (GO:0046113)2.95082199
106platelet dense granule organization (GO:0060155)2.93459821
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.92648733
108NADH dehydrogenase complex assembly (GO:0010257)2.92648733
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92648733
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91561911
111otic vesicle formation (GO:0030916)2.91241441
112L-amino acid import (GO:0043092)2.90190056
113establishment of mitochondrion localization (GO:0051654)2.89810714
114potassium ion import (GO:0010107)2.88188319
115positive regulation of sodium ion transport (GO:0010765)2.87363696
116membrane depolarization during action potential (GO:0086010)2.86743983
117protein complex biogenesis (GO:0070271)2.85874691
118response to histamine (GO:0034776)2.84057912
119protein polyglutamylation (GO:0018095)2.83889236
120membrane hyperpolarization (GO:0060081)2.83473174
121epithelial cilium movement (GO:0003351)2.82435485
122neurotransmitter secretion (GO:0007269)2.81613345
123regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.80989968
124ketone body metabolic process (GO:1902224)2.80722008
125cellular sodium ion homeostasis (GO:0006883)2.79612050
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78822471
127dopamine receptor signaling pathway (GO:0007212)2.78321326
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77491865
129neurotransmitter transport (GO:0006836)2.77071951
130alanine transport (GO:0032328)2.76497152
131cerebellar Purkinje cell differentiation (GO:0021702)2.75855823
132negative regulation of cation channel activity (GO:2001258)2.74697951
133ubiquinone biosynthetic process (GO:0006744)2.74542534
134cell communication involved in cardiac conduction (GO:0086065)2.74406606
135cellular response to ATP (GO:0071318)2.70334073
136neuronal action potential propagation (GO:0019227)2.68946071
137auditory receptor cell stereocilium organization (GO:0060088)2.68894095
138limb bud formation (GO:0060174)2.68830271
139somite development (GO:0061053)2.68700994
140mitochondrial respiratory chain complex assembly (GO:0033108)2.68132320
141negative regulation of mast cell activation (GO:0033004)2.67377489
142sulfation (GO:0051923)2.67043944
143inner ear receptor stereocilium organization (GO:0060122)2.66594390
144preassembly of GPI anchor in ER membrane (GO:0016254)2.66324126
145neuromuscular synaptic transmission (GO:0007274)2.66235899
146nonmotile primary cilium assembly (GO:0035058)2.65780461
147regulation of hexokinase activity (GO:1903299)2.65775784
148regulation of glucokinase activity (GO:0033131)2.65775784
149regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.65648447
150regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.65648447
151cellular response to radiation (GO:0071478)2.64335456
152regulation of neurotransmitter secretion (GO:0046928)2.64045795
153regulation of sodium ion transmembrane transport (GO:1902305)2.63670910
154regulation of sodium ion transmembrane transporter activity (GO:2000649)2.63518777
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63471480
156positive regulation of neurotransmitter transport (GO:0051590)2.62933568
157regulation of neurotransmitter uptake (GO:0051580)2.61108674
158positive regulation of cyclase activity (GO:0031281)2.61067785
159ubiquinone metabolic process (GO:0006743)2.60735127
160parturition (GO:0007567)2.59402321
161rRNA catabolic process (GO:0016075)2.59347115
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59304873
163phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.57293055
164axon cargo transport (GO:0008088)2.54313833
165phosphatidylserine acyl-chain remodeling (GO:0036150)2.53600065
166glycerophospholipid catabolic process (GO:0046475)2.49780802
167cellular biogenic amine catabolic process (GO:0042402)2.48842246
168amine catabolic process (GO:0009310)2.48842246
169cornea development in camera-type eye (GO:0061303)2.48292407
170action potential (GO:0001508)2.48099685
171cilium morphogenesis (GO:0060271)2.47589863
172somite rostral/caudal axis specification (GO:0032525)2.44291822
173positive regulation of gastrulation (GO:2000543)2.43873745
174positive regulation of fatty acid transport (GO:2000193)2.42803845
175startle response (GO:0001964)2.42134736
176hindbrain development (GO:0030902)2.41221373
177regulation of mesoderm development (GO:2000380)2.40831688
178negative regulation of reactive oxygen species metabolic process (GO:2000378)2.40268121
179DNA methylation involved in gamete generation (GO:0043046)2.39945339
180spinal cord motor neuron differentiation (GO:0021522)2.39724655
181postsynaptic membrane organization (GO:0001941)2.38711986
182protein localization to cilium (GO:0061512)2.38667716
183cAMP catabolic process (GO:0006198)2.38665092
184proton transport (GO:0015992)2.38544516
185electron transport chain (GO:0022900)2.38096451
186neurotransmitter metabolic process (GO:0042133)2.37961379
187opioid receptor signaling pathway (GO:0038003)2.37927453
188transmission of nerve impulse (GO:0019226)2.37881533
189regulation of rhodopsin mediated signaling pathway (GO:0022400)10.3440449
190rhodopsin mediated signaling pathway (GO:0016056)10.1379724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.18496041
2EZH2_22144423_ChIP-Seq_EOC_Human2.58649198
3IGF1R_20145208_ChIP-Seq_DFB_Human2.58491547
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.51942980
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49071419
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47756264
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42678798
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40550252
9REST_21632747_ChIP-Seq_MESCs_Mouse2.31617229
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30647903
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26721554
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26721554
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20399597
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16604052
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14222113
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.14146861
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13938859
18ZNF263_19887448_ChIP-Seq_K562_Human2.10098361
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07905742
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.05893752
21GBX2_23144817_ChIP-Seq_PC3_Human2.05066049
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.03879127
23DROSHA_22980978_ChIP-Seq_HELA_Human2.01888809
24EWS_26573619_Chip-Seq_HEK293_Human2.01129972
25TAF15_26573619_Chip-Seq_HEK293_Human1.95721221
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.95320623
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94483218
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93015631
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91523494
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.91506891
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.91383472
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91191283
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.90353985
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88308701
35FUS_26573619_Chip-Seq_HEK293_Human1.88026262
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87070551
37P300_19829295_ChIP-Seq_ESCs_Human1.86092842
38AR_21572438_ChIP-Seq_LNCaP_Human1.85880838
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.83127565
40* KDM2B_26808549_Chip-Seq_K562_Human1.82563433
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79671590
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70026603
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65751097
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61368664
45ER_23166858_ChIP-Seq_MCF-7_Human1.59897851
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58372986
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57467404
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.56347443
49RNF2_27304074_Chip-Seq_NSC_Mouse1.55309169
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53293609
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52894640
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52286138
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.51766091
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48837406
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.48780446
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48059069
57* AR_19668381_ChIP-Seq_PC3_Human1.46199467
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.44692708
59TP53_22573176_ChIP-Seq_HFKS_Human1.44388836
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43237102
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43237102
62* AR_25329375_ChIP-Seq_VCAP_Human1.41539322
63* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40836654
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38110375
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37682797
66MYC_18940864_ChIP-ChIP_HL60_Human1.37103928
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.35715336
68* TET1_21490601_ChIP-Seq_MESCs_Mouse1.32641963
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32417381
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.32190287
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.32078209
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30849016
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30622342
74CBP_20019798_ChIP-Seq_JUKART_Human1.30402462
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30402462
76* TCF4_23295773_ChIP-Seq_U87_Human1.30027468
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29366612
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.29366612
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28739525
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27462968
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27420627
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27402278
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.25735022
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.25579869
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25244379
86TCF4_22108803_ChIP-Seq_LS180_Human1.20975378
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20745688
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20295007
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20108760
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20079729
91CTCF_27219007_Chip-Seq_Bcells_Human1.19848877
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19230373
93STAT3_23295773_ChIP-Seq_U87_Human1.19099480
94IRF1_19129219_ChIP-ChIP_H3396_Human1.18474074
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18212861
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17591778
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.17431092
98AHR_22903824_ChIP-Seq_MCF-7_Human1.16983616
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.16350930
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15730252
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15700537
102* SOX2_19829295_ChIP-Seq_ESCs_Human1.15651841
103* NANOG_19829295_ChIP-Seq_ESCs_Human1.15651841
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15508508
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13827528
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13778875
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13586721
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13426502
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.12931184
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11646889
111RUNX2_22187159_ChIP-Seq_PCA_Human1.11315985
112NCOR_22424771_ChIP-Seq_293T_Human1.11069051
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10575528
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10434782
115TBL1_22424771_ChIP-Seq_293T_Human1.09061242
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09008438
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08376713
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08372841
119* AR_20517297_ChIP-Seq_VCAP_Human1.07106917
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.07057158
121TCF4_18268006_ChIP-ChIP_LS174T_Human1.06954679
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.06655644
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05807033
124HOXB7_26014856_ChIP-Seq_BT474_Human1.05681729
125ZNF274_21170338_ChIP-Seq_K562_Hela1.05363161
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.04489448
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04165368
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03649496
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.03475114
130* SMAD3_21741376_ChIP-Seq_ESCs_Human1.02507324
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02117191
132ERA_21632823_ChIP-Seq_H3396_Human1.01867326
133IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01856882
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01837691
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01589968
136EP300_21415370_ChIP-Seq_HL-1_Mouse1.00817460
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00623319
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00492809
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00471791
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.99320736
141NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97923029
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97130107
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.96808622
144BCAT_22108803_ChIP-Seq_LS180_Human0.95622454
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95106836
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94972619
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93688673
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93583579
149KLF4_19829295_ChIP-Seq_ESCs_Human0.93308104
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93046617
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92767489
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92496352
153OCT4_19829295_ChIP-Seq_ESCs_Human0.92238553
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.90735900
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90447209
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90444199
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90373112
158* ISL1_27105846_Chip-Seq_CPCs_Mouse0.90316030
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89611227
160CREB1_26743006_Chip-Seq_LNCaP_Human0.89485370
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89144786
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88348364
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86867304
164* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86563018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.32781138
2MP0003011_delayed_dark_adaptation6.09825494
3MP0005253_abnormal_eye_physiology4.47849796
4MP0006072_abnormal_retinal_apoptosis4.45811006
5MP0004270_analgesia3.33876392
6MP0004858_abnormal_nervous_system2.89783439
7MP0002102_abnormal_ear_morphology2.89121853
8MP0001986_abnormal_taste_sensitivity2.86892458
9MP0005423_abnormal_somatic_nervous2.83759509
10MP0001968_abnormal_touch/_nociception2.79212637
11MP0003195_calcinosis2.77727150
12MP0003950_abnormal_plasma_membrane2.73648018
13MP0004859_abnormal_synaptic_plasticity2.59429893
14MP0003136_yellow_coat_color2.59355569
15MP0002735_abnormal_chemical_nociception2.54899036
16MP0000569_abnormal_digit_pigmentation2.52034380
17MP0005195_abnormal_posterior_eye2.38548278
18MP0002638_abnormal_pupillary_reflex2.37054451
19MP0002734_abnormal_mechanical_nocicepti2.33794252
20MP0002229_neurodegeneration2.27702497
21MP0002090_abnormal_vision2.22031945
22MP0005391_vision/eye_phenotype2.08578359
23MP0004142_abnormal_muscle_tone2.01743448
24MP0002653_abnormal_ependyma_morphology1.99872306
25MP0002736_abnormal_nociception_after1.95004624
26MP0004133_heterotaxia1.92017085
27MP0005645_abnormal_hypothalamus_physiol1.91106639
28MP0003635_abnormal_synaptic_transmissio1.88543111
29MP0001324_abnormal_eye_pigmentation1.87198119
30MP0008872_abnormal_physiological_respon1.86767830
31MP0004043_abnormal_pH_regulation1.83675135
32MP0002733_abnormal_thermal_nociception1.80148849
33MP0002837_dystrophic_cardiac_calcinosis1.80087931
34MP0003283_abnormal_digestive_organ1.79209661
35MP0002752_abnormal_somatic_nervous1.78901244
36MP0002882_abnormal_neuron_morphology1.76812720
37MP0004233_abnormal_muscle_weight1.76790591
38MP0008875_abnormal_xenobiotic_pharmacok1.76557134
39MP0009046_muscle_twitch1.73936554
40MP0002272_abnormal_nervous_system1.67124164
41MP0001970_abnormal_pain_threshold1.65547084
42MP0006276_abnormal_autonomic_nervous1.64029296
43MP0001485_abnormal_pinna_reflex1.59390982
44MP0004885_abnormal_endolymph1.57445961
45MP0001486_abnormal_startle_reflex1.57109835
46MP0002876_abnormal_thyroid_physiology1.54944344
47MP0002938_white_spotting1.53526973
48MP0002067_abnormal_sensory_capabilities1.50431391
49MP0003787_abnormal_imprinting1.49291688
50MP0006292_abnormal_olfactory_placode1.46712821
51MP0002063_abnormal_learning/memory/cond1.45219021
52MP0002064_seizures1.44943931
53MP0009379_abnormal_foot_pigmentation1.40428779
54MP0003880_abnormal_central_pattern1.39593212
55MP0001502_abnormal_circadian_rhythm1.38210065
56MP0005174_abnormal_tail_pigmentation1.36087193
57MP0000372_irregular_coat_pigmentation1.35586700
58MP0002184_abnormal_innervation1.33075212
59MP0009745_abnormal_behavioral_response1.31617495
60MP0002572_abnormal_emotion/affect_behav1.30198847
61MP0004147_increased_porphyrin_level1.28536883
62MP0005187_abnormal_penis_morphology1.25397004
63MP0001984_abnormal_olfaction1.24757903
64MP0000427_abnormal_hair_cycle1.21154425
65MP0003329_amyloid_beta_deposits1.21008575
66MP0003634_abnormal_glial_cell1.18936385
67MP0002277_abnormal_respiratory_mucosa1.18364319
68MP0000955_abnormal_spinal_cord1.18132769
69MP0001299_abnormal_eye_distance/1.15384404
70MP0000026_abnormal_inner_ear1.14468937
71MP0004811_abnormal_neuron_physiology1.13666376
72MP0005084_abnormal_gallbladder_morpholo1.11925901
73MP0001529_abnormal_vocalization1.11350462
74MP0008569_lethality_at_weaning1.10952806
75MP0001440_abnormal_grooming_behavior1.07814129
76MP0002160_abnormal_reproductive_system1.07485334
77MP0003119_abnormal_digestive_system1.04359903
78MP0000778_abnormal_nervous_system1.02384053
79MP0002234_abnormal_pharynx_morphology1.01996159
80MP0002909_abnormal_adrenal_gland1.01916797
81MP0002751_abnormal_autonomic_nervous1.01582653
82MP0003646_muscle_fatigue1.01571638
83MP0008995_early_reproductive_senescence1.00808495
84MP0004145_abnormal_muscle_electrophysio1.00127685
85MP0003137_abnormal_impulse_conducting0.99991911
86MP0005389_reproductive_system_phenotype0.98210640
87MP0000751_myopathy0.97057054
88MP0009780_abnormal_chondrocyte_physiolo0.96421378
89MP0002095_abnormal_skin_pigmentation0.95963962
90MP0003938_abnormal_ear_development0.94974121
91MP0002928_abnormal_bile_duct0.94962979
92MP0005386_behavior/neurological_phenoty0.93108668
93MP0004924_abnormal_behavior0.93108668
94MP0001919_abnormal_reproductive_system0.89170825
95MP0002822_catalepsy0.88840347
96MP0000566_synostosis0.88584871
97MP0000747_muscle_weakness0.85040338
98MP0002066_abnormal_motor_capabilities/c0.82962204
99MP0002127_abnormal_cardiovascular_syste0.82148274
100MP0005623_abnormal_meninges_morphology0.81348396
101MP0000749_muscle_degeneration0.79779683
102MP0002163_abnormal_gland_morphology0.79307305
103MP0003937_abnormal_limbs/digits/tail_de0.78262434
104MP0001764_abnormal_homeostasis0.77674055
105MP0005085_abnormal_gallbladder_physiolo0.76988737
106MP0002152_abnormal_brain_morphology0.75822323
107MP0000049_abnormal_middle_ear0.75526934
108MP0005499_abnormal_olfactory_system0.74778250
109MP0005394_taste/olfaction_phenotype0.74778250
110MP0001501_abnormal_sleep_pattern0.72797159
111MP0000230_abnormal_systemic_arterial0.72694589
112MP0000534_abnormal_ureter_morphology0.72235664
113MP0002557_abnormal_social/conspecific_i0.71151502
114MP0005197_abnormal_uvea_morphology0.70774417
115MP0001963_abnormal_hearing_physiology0.70377237
116MP0004215_abnormal_myocardial_fiber0.69993836
117MP0004084_abnormal_cardiac_muscle0.67346980
118MP0003123_paternal_imprinting0.67078439
119MP0003632_abnormal_nervous_system0.66821614
120MP0002269_muscular_atrophy0.65305523
121MP0003045_fibrosis0.61058920
122MP0000647_abnormal_sebaceous_gland0.60580621
123MP0003631_nervous_system_phenotype0.60435908
124MP0003861_abnormal_nervous_system0.60217177
125MP0005646_abnormal_pituitary_gland0.59592404
126MP0004085_abnormal_heartbeat0.59176563
127MP0003633_abnormal_nervous_system0.58759020
128MP0003878_abnormal_ear_physiology0.58544802
129MP0005377_hearing/vestibular/ear_phenot0.58544802
130MP0003879_abnormal_hair_cell0.57268852
131MP0004036_abnormal_muscle_relaxation0.57060858
132MP0000579_abnormal_nail_morphology0.53366018
133MP0008961_abnormal_basal_metabolism0.53294069
134MP0003122_maternal_imprinting0.52672543
135MP0000631_abnormal_neuroendocrine_gland0.52415315
136MP0010386_abnormal_urinary_bladder0.50516978
137MP0001905_abnormal_dopamine_level0.49761851
138MP0000462_abnormal_digestive_system0.49287113
139MP0008789_abnormal_olfactory_epithelium0.48307043
140MP0008877_abnormal_DNA_methylation0.46074558
141MP0010030_abnormal_orbit_morphology0.45722211
142MP0005620_abnormal_muscle_contractility0.44002628
143MP0004742_abnormal_vestibular_system0.43530231

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.08838483
2Abnormal rod and cone electroretinograms (HP:0008323)6.99909471
3Central scotoma (HP:0000603)6.96323040
4Absent rod-and cone-mediated responses on ERG (HP:0007688)6.88306623
5Scotoma (HP:0000575)6.46846034
6Dyschromatopsia (HP:0007641)6.39552280
7Chorioretinal atrophy (HP:0000533)6.35538524
8Abnormality of macular pigmentation (HP:0008002)6.28991782
9Pigmentary retinal degeneration (HP:0001146)6.12009255
10Attenuation of retinal blood vessels (HP:0007843)5.42641638
11Pendular nystagmus (HP:0012043)5.35115773
12Pancreatic cysts (HP:0001737)4.49644070
13Decreased central vision (HP:0007663)4.36075866
14Abolished electroretinogram (ERG) (HP:0000550)4.35852026
15Type II diabetes mellitus (HP:0005978)4.28495359
16Molar tooth sign on MRI (HP:0002419)4.28309138
17Abnormality of midbrain morphology (HP:0002418)4.28309138
18True hermaphroditism (HP:0010459)4.26003622
19Photophobia (HP:0000613)4.09649715
20Nephronophthisis (HP:0000090)3.87901031
21Keratoconus (HP:0000563)3.77577792
22Increased corneal curvature (HP:0100692)3.77577792
23Type II lissencephaly (HP:0007260)3.74123354
24Choroideremia (HP:0001139)3.65842110
25Macular degeneration (HP:0000608)3.59092266
26Posterior subcapsular cataract (HP:0007787)3.41634324
27Cone-rod dystrophy (HP:0000548)3.40228423
28Hyperalaninemia (HP:0003348)3.39290746
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.39290746
30Abnormality of alanine metabolism (HP:0010916)3.39290746
31Retinitis pigmentosa (HP:0000510)3.23724315
32Severe visual impairment (HP:0001141)3.21524761
33Abnormality of the renal medulla (HP:0100957)3.15006723
34Tubular atrophy (HP:0000092)3.11486255
35Concave nail (HP:0001598)3.07120929
36Myokymia (HP:0002411)3.03432040
37Vitreoretinal degeneration (HP:0000655)2.98674427
38Hyperventilation (HP:0002883)2.95061504
39Retinal atrophy (HP:0001105)2.93706235
40Constricted visual fields (HP:0001133)2.90894671
41Abnormality of the renal cortex (HP:0011035)2.85178653
42Action tremor (HP:0002345)2.81502926
43Cystic liver disease (HP:0006706)2.78032646
44Cerebellar dysplasia (HP:0007033)2.70962007
45Progressive cerebellar ataxia (HP:0002073)2.70565421
46Ulnar claw (HP:0001178)2.61409653
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60909044
48Lissencephaly (HP:0001339)2.60086193
49Sclerocornea (HP:0000647)2.55328675
50Chronic hepatic failure (HP:0100626)2.54793731
51Inability to walk (HP:0002540)2.54790060
52Patellar aplasia (HP:0006443)2.53134667
53Aplasia/Hypoplasia of the patella (HP:0006498)2.50360937
54Congenital, generalized hypertrichosis (HP:0004540)2.44229178
55Abnormal drinking behavior (HP:0030082)2.36652279
56Polydipsia (HP:0001959)2.36652279
57Anencephaly (HP:0002323)2.32325906
58Focal motor seizures (HP:0011153)2.29043463
59Male pseudohermaphroditism (HP:0000037)2.28243189
60Focal seizures (HP:0007359)2.27438386
61Furrowed tongue (HP:0000221)2.26866480
62Acute necrotizing encephalopathy (HP:0006965)2.25522495
63Progressive visual loss (HP:0000529)2.24940826
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23477261
65Visual hallucinations (HP:0002367)2.21174829
66Subcapsular cataract (HP:0000523)2.21051727
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.20424628
68Large for gestational age (HP:0001520)2.18757779
69Truncal ataxia (HP:0002078)2.17313057
70Bilateral microphthalmos (HP:0007633)2.17021221
71Optic nerve hypoplasia (HP:0000609)2.15782877
72Pheochromocytoma (HP:0002666)2.15515428
73Febrile seizures (HP:0002373)2.15116916
74Epileptic encephalopathy (HP:0200134)2.13736112
75Clumsiness (HP:0002312)2.13664678
76Mitochondrial inheritance (HP:0001427)2.12302675
77Ventricular fibrillation (HP:0001663)2.09349588
78Hypoplasia of the pons (HP:0012110)2.08797956
79Broad-based gait (HP:0002136)2.08236677
80Abnormality of the pons (HP:0007361)2.08022389
81Decreased circulating renin level (HP:0003351)2.06578434
82Congenital hepatic fibrosis (HP:0002612)2.05195192
83Wide nasal bridge (HP:0000431)2.03371140
84Congenital stationary night blindness (HP:0007642)11.3494966
85Abnormal biliary tract physiology (HP:0012439)1.97316589
86Bile duct proliferation (HP:0001408)1.97316589
87Acute encephalopathy (HP:0006846)1.97280888
88Birth length less than 3rd percentile (HP:0003561)1.97016507
89Dysdiadochokinesis (HP:0002075)1.96705557
90Increased CSF lactate (HP:0002490)1.96657169
91Absent/shortened dynein arms (HP:0200106)1.95724375
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.95724375
93Gait imbalance (HP:0002141)1.95237669
94Severe muscular hypotonia (HP:0006829)1.95027632
95Renal cortical cysts (HP:0000803)1.94255390
96Genetic anticipation (HP:0003743)1.93775677
97Protruding tongue (HP:0010808)1.93769872
98Abnormal respiratory epithelium morphology (HP:0012253)1.92618298
99Abnormal respiratory motile cilium morphology (HP:0005938)1.92618298
100Hemiparesis (HP:0001269)1.91947084
101Progressive macrocephaly (HP:0004481)1.91263555
102Tachypnea (HP:0002789)1.91170752
103Postaxial foot polydactyly (HP:0001830)1.89953561
104Retinal dysplasia (HP:0007973)1.88892108
105Progressive inability to walk (HP:0002505)1.86777082
106Congenital primary aphakia (HP:0007707)1.85709363
107Limb dystonia (HP:0002451)1.85480879
108Polyuria (HP:0000103)1.84911352
109Pachygyria (HP:0001302)1.84823476
110Abnormal mitochondria in muscle tissue (HP:0008316)1.84532801
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.84526423
112Segmental peripheral demyelination/remyelination (HP:0003481)1.84384118
113Insidious onset (HP:0003587)1.83933048
114Termporal pattern (HP:0011008)1.83933048
115Aplasia/hypoplasia of the uterus (HP:0008684)1.82654505
116Ankle clonus (HP:0011448)1.78240590
117Hyperglycinuria (HP:0003108)1.78058823
118Generalized tonic-clonic seizures (HP:0002069)1.76859158
119Supranuclear gaze palsy (HP:0000605)1.76386189
120Septo-optic dysplasia (HP:0100842)1.76157429
121Conical tooth (HP:0000698)1.74660544
122Urinary bladder sphincter dysfunction (HP:0002839)1.73453125
123Preaxial hand polydactyly (HP:0001177)1.72782748
1243-Methylglutaconic aciduria (HP:0003535)1.72640795
125Hypoventilation (HP:0002791)1.72607643
126Neoplasm of the heart (HP:0100544)1.71749945
127Genital tract atresia (HP:0001827)1.71288329
128Horizontal nystagmus (HP:0000666)1.71164611
129Neuroendocrine neoplasm (HP:0100634)1.71077702
130Atonic seizures (HP:0010819)1.70920892
131Amblyopia (HP:0000646)1.70146065
132Vaginal atresia (HP:0000148)1.69735534
133Fair hair (HP:0002286)1.69286416
134Abnormality of the labia minora (HP:0012880)1.69238537
135Impaired pain sensation (HP:0007328)1.67083197
136Abnormality of pain sensation (HP:0010832)1.67083197
137Megalencephaly (HP:0001355)1.66461539
138Absence seizures (HP:0002121)1.66296776
139Rib fusion (HP:0000902)1.66023731
140Abnormal number of erythroid precursors (HP:0012131)1.64582877
141Occipital encephalocele (HP:0002085)1.64041644
142Abnormality of the lower motor neuron (HP:0002366)1.63975765
143Methylmalonic acidemia (HP:0002912)1.63086873
144Annular pancreas (HP:0001734)1.59393907
145Hammertoe (HP:0001765)1.58903677
146Hypercortisolism (HP:0001578)1.58300618
147Depression (HP:0000716)1.57371730
148Nephrogenic diabetes insipidus (HP:0009806)1.57335474
149Hemiplegia (HP:0002301)1.56107534
150Poor coordination (HP:0002370)1.53549349
151Fetal akinesia sequence (HP:0001989)1.51304939
152Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.50323454
153Dialeptic seizures (HP:0011146)1.49415508
154Optic disc pallor (HP:0000543)1.47772862
155Medial flaring of the eyebrow (HP:0010747)1.43469025
156Aqueductal stenosis (HP:0002410)1.42744369
157Aplasia involving bones of the extremities (HP:0009825)1.41128645
158Aplasia involving bones of the upper limbs (HP:0009823)1.41128645
159Aplasia of the phalanges of the hand (HP:0009802)1.41128645
160Abnormality of the aortic arch (HP:0012303)1.38078949
161Insomnia (HP:0100785)1.37274143
162Gaze-evoked nystagmus (HP:0000640)1.35797438
163Urinary urgency (HP:0000012)1.35397341
164Failure to thrive in infancy (HP:0001531)1.35069477
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.31743842
166Thyroid carcinoma (HP:0002890)1.31052053
167Postural instability (HP:0002172)1.29334160
168Onion bulb formation (HP:0003383)1.29320196
169Dysmetric saccades (HP:0000641)1.29202647
170Neoplasm of the peripheral nervous system (HP:0100007)1.29178980
171Dysautonomia (HP:0002459)1.28151373
172Prolonged QT interval (HP:0001657)1.27290574
173Pancreatic fibrosis (HP:0100732)1.26753369
174Macroorchidism (HP:0000053)1.26567081
175Foot dorsiflexor weakness (HP:0009027)1.25450743
176Decreased motor nerve conduction velocity (HP:0003431)1.24491261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.24332760
2GRK14.07841673
3ADRBK23.61493727
4NTRK13.16754939
5MAP3K93.09289409
6TLK12.93205942
7WNK42.83878825
8NTRK32.75098012
9ZAK2.65299634
10INSRR2.63016834
11BMPR1B2.63009523
12CASK2.52255087
13MINK12.49534784
14LMTK22.49260752
15KSR22.37704103
16MAP4K22.37286865
17WNK32.32023857
18PRKD32.29023211
19ACVR1B2.25525468
20LATS22.23277194
21MAP3K42.19550060
22PINK12.12460846
23NEK12.12404756
24PAK62.07930137
25TAOK32.02499826
26NUAK11.89307691
27STK381.77213032
28PHKG21.74713260
29PHKG11.74713260
30PNCK1.69823489
31SGK21.67096826
32MAP3K21.65686755
33SGK4941.63663857
34SGK2231.63663857
35NTRK21.63249487
36RET1.58630972
37SGK31.54141429
38GRK51.51757311
39MARK11.48010206
40DYRK21.39033233
41TXK1.38570362
42CAMKK11.36329966
43PBK1.34578127
44MUSK1.27978967
45OXSR11.25875969
46MAP2K41.21894824
47TRIB31.17326277
48ADRBK11.15991265
49MAPK151.15823770
50OBSCN1.15797893
51ALK1.08565421
52BCKDK1.05042733
53CAMK1G1.04906204
54FER1.02319626
55TGFBR11.02053276
56CAMKK21.01968430
57BRSK11.01883439
58MATK1.01365017
59LATS11.00131633
60STK390.99201699
61MAPK130.99000355
62ERBB20.98464826
63CDK50.98454478
64CDC42BPA0.93323378
65AKT30.92895294
66KSR10.91471367
67SCYL20.90940734
68MAP2K70.89809353
69PRKCE0.88318452
70TNIK0.86583639
71TIE10.86552547
72MAP2K10.84633118
73MKNK20.82779188
74WNK10.81315652
75PRKAA10.79763836
76PRKCI0.79205180
77CSNK1G20.79070847
78VRK10.76318692
79PKN10.74010826
80CDK140.73870847
81MAPK120.73018698
82PRKCG0.72950758
83CDK190.72321628
84RPS6KA50.71251498
85CAMK1D0.71087091
86NME10.69873376
87LIMK10.69442652
88ARAF0.67952836
89SIK10.67643808
90MAPK100.67583121
91CDK150.66192746
92RIPK10.66158733
93TYRO30.65988406
94CDK180.64860673
95RPS6KA20.64834021
96PDK40.64704817
97PDK30.64704817
98EPHA40.63272960
99PRKCH0.62570595
100RPS6KA30.62472618
101BCR0.61738801
102PRKCZ0.60061746
103PRKACA0.59411035
104MAPKAPK50.59280625
105PIK3CA0.58588997
106STK38L0.57826314
107IRAK20.57009318
108TAOK10.55645019
109CSNK1E0.54948176
110PLK20.54622559
111CDK11A0.54608188
112MAP3K60.52843219
113ICK0.52565671
114SIK20.52370022
115WEE10.52248580
116PLK30.51288686
117MAP2K60.50681883
118AKT20.50396500
119MAPKAPK30.49266917
120ROCK10.48874736
121PRKCQ0.48857620
122DAPK20.47887177
123PDGFRA0.47235206
124TRIM280.46996757
125TTK0.46971538
126TSSK60.46865392
127NEK20.46711996
128FGFR10.46558926
129CHUK0.46521131
130PAK30.46336699
131PRKCB0.45793268
132CSNK1D0.45743084
133GSK3B0.45564650
134CSNK1A10.45085379
135FGFR20.44704204
136IKBKB0.44668315
137KIT0.44419773
138CHEK20.44352028
139MKNK10.44335112
140BRSK20.44305127
141CAMK10.44144387
142STK110.44117670
143CAMK2A0.44092945
144IRAK10.43697535
145PRKG10.43171057
146MAPK80.42481526
147CSNK1G10.42343511
148DYRK1A0.42324129
149PDK10.41935268
150PTK2B0.41928952
151CSNK1G30.41514545
152MAP3K10.40560985
153PRKCA0.38969124
154GRK70.37082537
155RPS6KA60.34837655
156TEC0.32934252
157PLK40.32263325
158PASK0.31977591
159SYK0.29911322

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.04494484
2Oxidative phosphorylation_Homo sapiens_hsa001902.92060555
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85967990
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71546559
5Synaptic vesicle cycle_Homo sapiens_hsa047212.59516463
6Parkinsons disease_Homo sapiens_hsa050122.33647268
7Butanoate metabolism_Homo sapiens_hsa006502.12856341
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11747349
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04522690
10Caffeine metabolism_Homo sapiens_hsa002322.04184317
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.03141815
12Phototransduction_Homo sapiens_hsa0474410.8659456
13Olfactory transduction_Homo sapiens_hsa047401.96637414
14Ether lipid metabolism_Homo sapiens_hsa005651.95938893
15Selenocompound metabolism_Homo sapiens_hsa004501.91903001
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89470855
17Tryptophan metabolism_Homo sapiens_hsa003801.86857038
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84367640
19Nitrogen metabolism_Homo sapiens_hsa009101.77670059
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75482123
21GABAergic synapse_Homo sapiens_hsa047271.75046618
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70902970
23Alzheimers disease_Homo sapiens_hsa050101.55568543
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55107423
25Glutamatergic synapse_Homo sapiens_hsa047241.54379906
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50276610
27Circadian entrainment_Homo sapiens_hsa047131.49818344
28Insulin secretion_Homo sapiens_hsa049111.48581197
29Huntingtons disease_Homo sapiens_hsa050161.43329817
30Cholinergic synapse_Homo sapiens_hsa047251.42517784
31Dopaminergic synapse_Homo sapiens_hsa047281.42146519
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39824115
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39294792
34Nicotine addiction_Homo sapiens_hsa050331.38104014
35RNA polymerase_Homo sapiens_hsa030201.34637133
36Circadian rhythm_Homo sapiens_hsa047101.34267935
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33578997
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.33566347
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32556519
40Protein export_Homo sapiens_hsa030601.32301337
41Salivary secretion_Homo sapiens_hsa049701.31677784
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27254354
43Long-term potentiation_Homo sapiens_hsa047201.25772400
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23090829
45Morphine addiction_Homo sapiens_hsa050321.21246494
46Basal transcription factors_Homo sapiens_hsa030221.18871032
47Arachidonic acid metabolism_Homo sapiens_hsa005901.17476148
48Fanconi anemia pathway_Homo sapiens_hsa034601.16840052
49Gastric acid secretion_Homo sapiens_hsa049711.13289050
50Dorso-ventral axis formation_Homo sapiens_hsa043201.08702737
51Peroxisome_Homo sapiens_hsa041461.08286740
52Serotonergic synapse_Homo sapiens_hsa047261.07588595
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07405180
54Ribosome_Homo sapiens_hsa030101.05804799
55GnRH signaling pathway_Homo sapiens_hsa049121.04722645
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03493333
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03259384
58Homologous recombination_Homo sapiens_hsa034401.02537724
59Oocyte meiosis_Homo sapiens_hsa041141.02408092
60Chemical carcinogenesis_Homo sapiens_hsa052041.00944237
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99987799
62Sulfur relay system_Homo sapiens_hsa041220.99652101
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99348915
64Hedgehog signaling pathway_Homo sapiens_hsa043400.98057186
65ABC transporters_Homo sapiens_hsa020100.96298274
66mTOR signaling pathway_Homo sapiens_hsa041500.95934585
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.95272568
68Oxytocin signaling pathway_Homo sapiens_hsa049210.93501862
69Amphetamine addiction_Homo sapiens_hsa050310.92418832
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91378812
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91034042
72Ovarian steroidogenesis_Homo sapiens_hsa049130.89964177
73Propanoate metabolism_Homo sapiens_hsa006400.87933988
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86021167
75RNA degradation_Homo sapiens_hsa030180.85176452
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.85132054
77Retinol metabolism_Homo sapiens_hsa008300.84920794
78Glioma_Homo sapiens_hsa052140.84221803
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82821895
80Renin secretion_Homo sapiens_hsa049240.81227342
81Long-term depression_Homo sapiens_hsa047300.80467854
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.79518511
83Cocaine addiction_Homo sapiens_hsa050300.79158545
84One carbon pool by folate_Homo sapiens_hsa006700.78804596
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.77689106
86cAMP signaling pathway_Homo sapiens_hsa040240.77403973
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75138182
88Gap junction_Homo sapiens_hsa045400.74924678
89Cardiac muscle contraction_Homo sapiens_hsa042600.74798296
90Alcoholism_Homo sapiens_hsa050340.74345625
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73843431
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72477792
93Estrogen signaling pathway_Homo sapiens_hsa049150.72068142
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71949554
95Fat digestion and absorption_Homo sapiens_hsa049750.71111060
96Histidine metabolism_Homo sapiens_hsa003400.68961484
97Vitamin B6 metabolism_Homo sapiens_hsa007500.68945555
98Melanogenesis_Homo sapiens_hsa049160.68835386
99beta-Alanine metabolism_Homo sapiens_hsa004100.68247389
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68118927
101Fatty acid biosynthesis_Homo sapiens_hsa000610.68065855
102Calcium signaling pathway_Homo sapiens_hsa040200.67933106
103Dilated cardiomyopathy_Homo sapiens_hsa054140.65631086
104ErbB signaling pathway_Homo sapiens_hsa040120.65192217
105Taste transduction_Homo sapiens_hsa047420.64588018
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60700276
107Thyroid hormone synthesis_Homo sapiens_hsa049180.60633984
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.60507351
109Pancreatic secretion_Homo sapiens_hsa049720.60156878
110Glucagon signaling pathway_Homo sapiens_hsa049220.60095508
111Metabolic pathways_Homo sapiens_hsa011000.59089738
112Basal cell carcinoma_Homo sapiens_hsa052170.58318338
113Endometrial cancer_Homo sapiens_hsa052130.55722669
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.55636796
115Type II diabetes mellitus_Homo sapiens_hsa049300.55194682
116Inositol phosphate metabolism_Homo sapiens_hsa005620.55053991
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54713303
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53824746
119Insulin signaling pathway_Homo sapiens_hsa049100.53535381
120Steroid biosynthesis_Homo sapiens_hsa001000.52298744
121Hippo signaling pathway_Homo sapiens_hsa043900.52048501
122Choline metabolism in cancer_Homo sapiens_hsa052310.51646868
123Tight junction_Homo sapiens_hsa045300.49041936
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.48815144
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48256435
126Purine metabolism_Homo sapiens_hsa002300.48221012
127Bile secretion_Homo sapiens_hsa049760.48197197
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47321397
129MAPK signaling pathway_Homo sapiens_hsa040100.44844614
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44659490
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44368649
132Mineral absorption_Homo sapiens_hsa049780.44325915
133Fructose and mannose metabolism_Homo sapiens_hsa000510.44107139
134Endocytosis_Homo sapiens_hsa041440.43690640
135Thyroid cancer_Homo sapiens_hsa052160.42488976
136Sulfur metabolism_Homo sapiens_hsa009200.42373126
137Vitamin digestion and absorption_Homo sapiens_hsa049770.40926056
138VEGF signaling pathway_Homo sapiens_hsa043700.40822170
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40068904
140Axon guidance_Homo sapiens_hsa043600.38678390
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37842951
142Wnt signaling pathway_Homo sapiens_hsa043100.37389254
143Renal cell carcinoma_Homo sapiens_hsa052110.37284773
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37117096
145Glycerolipid metabolism_Homo sapiens_hsa005610.36831165
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36225364
147Ras signaling pathway_Homo sapiens_hsa040140.36082116
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35506841
149Non-small cell lung cancer_Homo sapiens_hsa052230.35409180
150Collecting duct acid secretion_Homo sapiens_hsa049660.33970242
151AMPK signaling pathway_Homo sapiens_hsa041520.33933843
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33596214
153Arginine biosynthesis_Homo sapiens_hsa002200.33581746
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33276323
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32548004
156Regulation of autophagy_Homo sapiens_hsa041400.32303447
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32008781
158HIF-1 signaling pathway_Homo sapiens_hsa040660.31361638
159Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29933811
160Rap1 signaling pathway_Homo sapiens_hsa040150.29816675
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24982718

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