FRMPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.91371688
2left/right pattern formation (GO:0060972)7.24756957
3regulation of cilium movement (GO:0003352)7.02876471
4ventricular system development (GO:0021591)6.55524302
5left/right axis specification (GO:0070986)6.52304697
6microtubule bundle formation (GO:0001578)5.81986028
7cilium organization (GO:0044782)5.41075788
8intraciliary transport (GO:0042073)5.27326347
9cilium assembly (GO:0042384)5.25327322
10vitamin transmembrane transport (GO:0035461)5.06986698
11microtubule-based movement (GO:0007018)4.66271808
12primary alcohol catabolic process (GO:0034310)4.62182423
13protein localization to cilium (GO:0061512)4.58786844
14regulation of microtubule-based movement (GO:0060632)4.44665965
15negative regulation of inclusion body assembly (GO:0090084)4.38530715
16cellular component assembly involved in morphogenesis (GO:0010927)4.28295860
17one-carbon compound transport (GO:0019755)4.23280849
18sperm capacitation (GO:0048240)4.15015358
19ethanol metabolic process (GO:0006067)4.12371393
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.02253731
21centriole assembly (GO:0098534)3.98418983
22synaptic vesicle maturation (GO:0016188)3.92712672
23cilium morphogenesis (GO:0060271)3.85252435
24microtubule polymerization or depolymerization (GO:0031109)3.83542431
25lateral ventricle development (GO:0021670)3.79519648
26diterpenoid biosynthetic process (GO:0016102)3.78530314
27cell projection assembly (GO:0030031)3.74038539
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71637917
29regulation of interleukin-5 production (GO:0032674)3.69001609
30regulation of interleukin-13 production (GO:0032656)3.63201676
31sperm motility (GO:0030317)3.50182188
32response to xenobiotic stimulus (GO:0009410)3.47492167
33negative regulation of immunoglobulin mediated immune response (GO:0002890)3.43291036
34negative regulation of B cell mediated immunity (GO:0002713)3.43291036
35lung epithelium development (GO:0060428)3.39256325
36retinal cone cell development (GO:0046549)3.26971925
37glutamate secretion (GO:0014047)3.26411567
38glomerular epithelial cell development (GO:0072310)3.25599291
39pyrimidine-containing compound transmembrane transport (GO:0072531)3.25485877
40microtubule depolymerization (GO:0007019)3.19910865
41cytoplasmic microtubule organization (GO:0031122)3.18031945
42synaptic vesicle exocytosis (GO:0016079)3.17200634
43nucleoside diphosphate phosphorylation (GO:0006165)3.14863843
44ethanol oxidation (GO:0006069)3.09078439
45regulation of synaptic vesicle exocytosis (GO:2000300)3.02939908
46vocalization behavior (GO:0071625)2.98460876
47negative regulation of T cell differentiation in thymus (GO:0033085)2.97442328
48apical protein localization (GO:0045176)2.92345752
49retinal rod cell development (GO:0046548)2.86553090
50establishment of apical/basal cell polarity (GO:0035089)2.84856325
51positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81037960
52regulation of germinal center formation (GO:0002634)2.78029430
53retinoic acid metabolic process (GO:0042573)2.76378664
54determination of left/right symmetry (GO:0007368)2.76224012
55negative regulation of humoral immune response (GO:0002921)2.74590264
56regulation of inclusion body assembly (GO:0090083)2.73122132
57microtubule-based process (GO:0007017)2.67776158
58ionotropic glutamate receptor signaling pathway (GO:0035235)2.67566609
59tolerance induction (GO:0002507)2.66194929
60determination of bilateral symmetry (GO:0009855)2.64509361
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64297637
62neurotransmitter secretion (GO:0007269)2.62819116
63neurotransmitter catabolic process (GO:0042135)2.62496345
64specification of symmetry (GO:0009799)2.58908747
65establishment of monopolar cell polarity (GO:0061162)2.57904998
66establishment or maintenance of monopolar cell polarity (GO:0061339)2.57904998
67cerebellar granule cell differentiation (GO:0021707)2.57631570
68smoothened signaling pathway (GO:0007224)2.56530619
69photoreceptor cell maintenance (GO:0045494)2.55935720
70regulation of synaptic vesicle transport (GO:1902803)2.55088768
71phosphorelay signal transduction system (GO:0000160)2.55058561
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54672603
73synaptic transmission, glutamatergic (GO:0035249)2.51898734
74regulation of voltage-gated calcium channel activity (GO:1901385)2.50016821
75centriole replication (GO:0007099)2.49967529
76aldehyde catabolic process (GO:0046185)2.49713420
77terpenoid biosynthetic process (GO:0016114)2.48875842
78regulation of neuronal synaptic plasticity (GO:0048168)2.44501623
79regulation of microtubule depolymerization (GO:0031114)2.41499590
80sodium ion homeostasis (GO:0055078)2.41280262
81exogenous drug catabolic process (GO:0042738)2.39145053
82regulation of neurotransmitter levels (GO:0001505)2.35904297
83O-glycan processing (GO:0016266)2.34010440
84regulation of ARF protein signal transduction (GO:0032012)2.32676449
85establishment of planar polarity (GO:0001736)2.31909108
86establishment of tissue polarity (GO:0007164)2.31909108
87positive regulation of smoothened signaling pathway (GO:0045880)2.31799531
88protein polyglutamylation (GO:0018095)2.28958678
89organelle assembly (GO:0070925)2.28658217
90locomotory exploration behavior (GO:0035641)2.27617633
91L-amino acid import (GO:0043092)2.27440398
92gamma-aminobutyric acid transport (GO:0015812)2.26513986
93regulation of collateral sprouting (GO:0048670)2.26500078
94neurotransmitter metabolic process (GO:0042133)2.25943145
95axonemal dynein complex assembly (GO:0070286)17.6407011
96cilium or flagellum-dependent cell motility (GO:0001539)17.0038015
97cilium movement (GO:0003341)13.9907386
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.6646901
99motile cilium assembly (GO:0044458)12.1256020
100epithelial cilium movement (GO:0003351)11.5132894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* DROSHA_22980978_ChIP-Seq_HELA_Human3.78129774
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58694305
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53240764
4EZH2_22144423_ChIP-Seq_EOC_Human2.43239820
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28754288
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17655260
7AR_21572438_ChIP-Seq_LNCaP_Human2.07335457
8GBX2_23144817_ChIP-Seq_PC3_Human2.04296647
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97607502
10PIAS1_25552417_ChIP-Seq_VCAP_Human1.92697378
11REST_21632747_ChIP-Seq_MESCs_Mouse1.89511182
12VDR_22108803_ChIP-Seq_LS180_Human1.84655844
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82876707
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68690593
15SMAD4_21799915_ChIP-Seq_A2780_Human1.68564671
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.66903273
17AHR_22903824_ChIP-Seq_MCF-7_Human1.62128964
18NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58710677
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57488622
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55480503
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.53411682
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52016661
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49254903
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48854744
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47133286
26* STAT3_23295773_ChIP-Seq_U87_Human1.44036038
27* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43795950
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43118764
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42888874
30TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.42409108
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41456592
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39780076
33* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39544810
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38688091
35* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37905089
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35827711
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35301363
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32027999
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31602049
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29878170
41TCF4_23295773_ChIP-Seq_U87_Human1.28478068
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.27695892
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26738142
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26005170
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25917572
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.25907603
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.23181265
48* TP53_18474530_ChIP-ChIP_U2OS_Human1.22693503
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20368295
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20311361
51TP53_16413492_ChIP-PET_HCT116_Human1.19008879
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18463296
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18463296
54SMAD4_21741376_ChIP-Seq_HESCs_Human1.18178094
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16244420
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.15895955
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.14962962
58* AR_19668381_ChIP-Seq_PC3_Human1.14313084
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13709820
60TP63_23658742_ChIP-Seq_EP156T_Human1.13013896
61ETV1_20927104_ChIP-Seq_GIST48_Human1.11323673
62TCF4_22108803_ChIP-Seq_LS180_Human1.10735793
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10191481
64* SMAD4_21741376_ChIP-Seq_EPCs_Human1.10010145
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09735299
66BCAT_22108803_ChIP-Seq_LS180_Human1.09215329
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08817623
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08523429
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07684532
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.07507650
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06718772
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06718772
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06388713
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06028115
75SMRT_27268052_Chip-Seq_Bcells_Human1.05935527
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.05821595
77* SMC4_20622854_ChIP-Seq_HELA_Human1.05372337
78AR_25329375_ChIP-Seq_VCAP_Human1.04323479
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.02498131
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.02383226
81RUNX2_22187159_ChIP-Seq_PCA_Human1.01878632
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01842721
83CBP_20019798_ChIP-Seq_JUKART_Human1.01842721
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01229571
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.01026316
86P300_19829295_ChIP-Seq_ESCs_Human1.00265845
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99952725
88CTCF_27219007_Chip-Seq_Bcells_Human0.98744032
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98555327
90WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98273494
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.97697279
92TAF15_26573619_Chip-Seq_HEK293_Human0.97473600
93EED_16625203_ChIP-ChIP_MESCs_Mouse0.97334007
94CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96452137
95* TBL1_22424771_ChIP-Seq_293T_Human0.96447774
96* PHF8_20622853_ChIP-Seq_HELA_Human0.94765869
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93539731
98STAT1_20625510_ChIP-Seq_HELA_Human0.92634658
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91509858
100ER_23166858_ChIP-Seq_MCF-7_Human0.91326966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.37047659
2MP0004859_abnormal_synaptic_plasticity4.33702820
3MP0008875_abnormal_xenobiotic_pharmacok4.17051137
4MP0001984_abnormal_olfaction3.95870555
5MP0005623_abnormal_meninges_morphology3.38258811
6MP0003880_abnormal_central_pattern3.06347370
7MP0009046_muscle_twitch2.95745849
8MP0004043_abnormal_pH_regulation2.84032829
9MP0009780_abnormal_chondrocyte_physiolo2.77751287
10MP0004270_analgesia2.65883219
11MP0002734_abnormal_mechanical_nocicepti2.64734570
12MP0002735_abnormal_chemical_nociception2.61029317
13MP0002132_abnormal_respiratory_system2.60591553
14MP0003635_abnormal_synaptic_transmissio2.55649273
15MP0009745_abnormal_behavioral_response2.44789328
16MP0001486_abnormal_startle_reflex2.32975250
17MP0002064_seizures2.29259756
18MP0004133_heterotaxia2.27756477
19MP0002272_abnormal_nervous_system2.14015112
20MP0005377_hearing/vestibular/ear_phenot2.10749100
21MP0003878_abnormal_ear_physiology2.10749100
22MP0002572_abnormal_emotion/affect_behav2.09608666
23MP0002063_abnormal_learning/memory/cond2.05531187
24MP0003879_abnormal_hair_cell2.01889043
25MP0001968_abnormal_touch/_nociception1.88112737
26MP0005646_abnormal_pituitary_gland1.81337647
27MP0001501_abnormal_sleep_pattern1.79746926
28MP0001485_abnormal_pinna_reflex1.76920864
29MP0001970_abnormal_pain_threshold1.75131580
30MP0005423_abnormal_somatic_nervous1.68842437
31MP0002822_catalepsy1.65366281
32MP0002277_abnormal_respiratory_mucosa1.58701041
33MP0005551_abnormal_eye_electrophysiolog1.54442572
34MP0001765_abnormal_ion_homeostasis1.42848020
35MP0002909_abnormal_adrenal_gland1.41648198
36MP0000383_abnormal_hair_follicle1.41504826
37MP0003633_abnormal_nervous_system1.40448894
38MP0005394_taste/olfaction_phenotype1.38864104
39MP0005499_abnormal_olfactory_system1.38864104
40MP0002736_abnormal_nociception_after1.37665397
41MP0002557_abnormal_social/conspecific_i1.37531661
42MP0001346_abnormal_lacrimal_gland1.36980051
43MP0002160_abnormal_reproductive_system1.36344219
44MP0008789_abnormal_olfactory_epithelium1.35317062
45MP0002229_neurodegeneration1.34889508
46MP0002282_abnormal_trachea_morphology1.34441500
47MP0000566_synostosis1.33887259
48MP0002067_abnormal_sensory_capabilities1.28482236
49MP0002638_abnormal_pupillary_reflex1.27694086
50MP0002168_other_aberrant_phenotype1.23651593
51MP0000955_abnormal_spinal_cord1.21553571
52MP0002733_abnormal_thermal_nociception1.17073131
53MP0001963_abnormal_hearing_physiology1.15316009
54MP0003698_abnormal_male_reproductive1.14407575
55MP0004019_abnormal_vitamin_homeostasis1.14089578
56MP0002882_abnormal_neuron_morphology1.13529052
57MP0003631_nervous_system_phenotype1.12938774
58MP0006276_abnormal_autonomic_nervous1.12474162
59MP0003136_yellow_coat_color1.07175342
60MP0010678_abnormal_skin_adnexa1.05382623
61MP0002249_abnormal_larynx_morphology1.04473086
62MP0008872_abnormal_physiological_respon1.02933354
63MP0005253_abnormal_eye_physiology1.01912023
64MP0000026_abnormal_inner_ear1.00192620
65MP0002066_abnormal_motor_capabilities/c0.99399816
66MP0002876_abnormal_thyroid_physiology0.98754978
67MP0001502_abnormal_circadian_rhythm0.96951749
68MP0004811_abnormal_neuron_physiology0.96709093
69MP0001905_abnormal_dopamine_level0.95929728
70MP0003656_abnormal_erythrocyte_physiolo0.95136611
71MP0004742_abnormal_vestibular_system0.94981821
72MP0008569_lethality_at_weaning0.93370125
73MP0005386_behavior/neurological_phenoty0.89896062
74MP0004924_abnormal_behavior0.89896062
75MP0003329_amyloid_beta_deposits0.89217186
76MP0005410_abnormal_fertilization0.87824820
77MP0005645_abnormal_hypothalamus_physiol0.86543865
78MP0001929_abnormal_gametogenesis0.85830836
79MP0005636_abnormal_mineral_homeostasis0.83364077
80MP0002152_abnormal_brain_morphology0.81029540
81MP0005310_abnormal_salivary_gland0.78974511
82MP0002928_abnormal_bile_duct0.77461343
83MP0001440_abnormal_grooming_behavior0.77113848
84MP0005395_other_phenotype0.74983213
85MP0003075_altered_response_to0.72484398
86MP0002752_abnormal_somatic_nervous0.71060554
87MP0000631_abnormal_neuroendocrine_gland0.70492280
88MP0003632_abnormal_nervous_system0.70469105
89MP0004147_increased_porphyrin_level0.69382805
90MP0000778_abnormal_nervous_system0.68146971
91MP0004885_abnormal_endolymph0.67109113
92MP0003690_abnormal_glial_cell0.66644549
93MP0000681_abnormal_thyroid_gland0.62881090
94MP0003634_abnormal_glial_cell0.62506275
95MP0002184_abnormal_innervation0.61838935
96MP0003045_fibrosis0.61255998
97MP0002161_abnormal_fertility/fecundity0.59276455
98MP0003861_abnormal_nervous_system0.59107478
99MP0003890_abnormal_embryonic-extraembry0.58751849
100MP0005389_reproductive_system_phenotype0.57852037

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.41508541
2Chronic bronchitis (HP:0004469)7.01798140
3Bronchiectasis (HP:0002110)6.90787637
4Nasal polyposis (HP:0100582)6.27101308
5Abnormality of the nasal mucosa (HP:0000433)5.15519832
6Recurrent sinusitis (HP:0011108)4.37547494
7Bronchitis (HP:0012387)4.05086824
8Infertility (HP:0000789)3.91547175
9Pancreatic fibrosis (HP:0100732)3.81127403
10True hermaphroditism (HP:0010459)3.71629856
11Recurrent otitis media (HP:0000403)3.65763714
12Chronic sinusitis (HP:0011109)3.64455030
13Occipital encephalocele (HP:0002085)3.63186599
14Male infertility (HP:0003251)3.48239702
15Pancreatic cysts (HP:0001737)3.14452671
16Cystic liver disease (HP:0006706)3.09629006
17Nephronophthisis (HP:0000090)3.08429997
18Chronic hepatic failure (HP:0100626)3.04572194
19Molar tooth sign on MRI (HP:0002419)3.00166254
20Abnormality of midbrain morphology (HP:0002418)3.00166254
21Chronic otitis media (HP:0000389)2.80506209
22Atelectasis (HP:0100750)2.58833439
23Postaxial foot polydactyly (HP:0001830)2.50709188
24Tubulointerstitial nephritis (HP:0001970)2.49268346
25Bell-shaped thorax (HP:0001591)2.45117993
26Hyperactive renin-angiotensin system (HP:0000841)2.44902022
27Abnormality of the renal medulla (HP:0100957)2.42040023
28Congenital hepatic fibrosis (HP:0002612)2.18159471
29Medial flaring of the eyebrow (HP:0010747)2.14365616
30Gait imbalance (HP:0002141)2.12283350
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.12039271
32Anencephaly (HP:0002323)2.06720769
33Recurrent bronchitis (HP:0002837)2.01097793
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0092791
35Dynein arm defect of respiratory motile cilia (HP:0012255)10.6814211
36Absent/shortened dynein arms (HP:0200106)10.6814211
37Abnormal ciliary motility (HP:0012262)10.5795271
38Abnormal respiratory motile cilium physiology (HP:0012261)10.5404383
39Abnormal respiratory epithelium morphology (HP:0012253)10.4721568
40Abnormal respiratory motile cilium morphology (HP:0005938)10.4721568
41Congenital primary aphakia (HP:0007707)1.99221038
42Myokymia (HP:0002411)1.96133128
43Male pseudohermaphroditism (HP:0000037)1.91992676
44Sclerocornea (HP:0000647)1.89397622
45Tubular atrophy (HP:0000092)1.82602985
46Furrowed tongue (HP:0000221)1.77730149
47Oculomotor apraxia (HP:0000657)1.74875574
48Nephrogenic diabetes insipidus (HP:0009806)1.73980194
49Asplenia (HP:0001746)1.73766390
50Hyperkalemia (HP:0002153)1.73551780
51Aplasia/Hypoplasia of the spleen (HP:0010451)1.69437245
52Renal salt wasting (HP:0000127)1.66748599
53Focal motor seizures (HP:0011153)1.65444125
54Postaxial hand polydactyly (HP:0001162)1.64845353
55Decreased circulating renin level (HP:0003351)1.63336916
56Progressive cerebellar ataxia (HP:0002073)1.54490114
57Genital tract atresia (HP:0001827)1.51743196
58Nephropathy (HP:0000112)1.51514014
59Decreased central vision (HP:0007663)1.50474210
60Vaginal atresia (HP:0000148)1.50081977
61Hyperaldosteronism (HP:0000859)1.48105485
62Poor coordination (HP:0002370)1.45863653
63Polydipsia (HP:0001959)1.44543892
64Abnormal drinking behavior (HP:0030082)1.44543892
65Absent frontal sinuses (HP:0002688)1.42823629
66Preaxial hand polydactyly (HP:0001177)1.42069721
67Tubulointerstitial abnormality (HP:0001969)1.41760875
68Absent speech (HP:0001344)1.41734612
69Focal seizures (HP:0007359)1.38272370
70Median cleft lip (HP:0000161)1.38247897
71Febrile seizures (HP:0002373)1.37266723
72Epileptic encephalopathy (HP:0200134)1.36838590
73Fetal akinesia sequence (HP:0001989)1.35686243
74Hand muscle atrophy (HP:0009130)1.35616573
75Abnormality of renin-angiotensin system (HP:0000847)1.34613939
76Stage 5 chronic kidney disease (HP:0003774)1.32613012
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.30359221
78Hypokalemic alkalosis (HP:0001949)1.30134212
79Central scotoma (HP:0000603)1.27157803
80Abnormality of chloride homeostasis (HP:0011422)1.25843359
81Abnormality of macular pigmentation (HP:0008002)1.23044140
82Bile duct proliferation (HP:0001408)1.22847990
83Abnormal biliary tract physiology (HP:0012439)1.22847990
84Cone-rod dystrophy (HP:0000548)1.19616193
85Gaze-evoked nystagmus (HP:0000640)1.19297033
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.17654559
87Abnormality of the renal cortex (HP:0011035)1.15110803
88Postural instability (HP:0002172)1.14424726
89Short thorax (HP:0010306)1.14198940
90Torticollis (HP:0000473)1.14131278
91Taurodontia (HP:0000679)1.13635305
92Abnormality of permanent molar morphology (HP:0011071)1.13635305
93Abnormality of the dental root (HP:0006486)1.13635305
94Supernumerary spleens (HP:0009799)1.11918272
95Obstructive sleep apnea (HP:0002870)1.11485529
96Abnormal rod and cone electroretinograms (HP:0008323)1.10308506
97Bifid scrotum (HP:0000048)1.09316429
98Ankle clonus (HP:0011448)1.07384813
99Action tremor (HP:0002345)1.07077984
100Abnormality of the dental pulp (HP:0006479)1.06514324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.41066536
2EPHA44.23006067
3MST43.67720756
4NTRK32.87512784
5RIPK42.77968005
6FRK2.29389422
7EPHA22.20820856
8DAPK22.15828802
9PNCK2.12785099
10PRKD31.98889751
11CAMKK11.93119273
12PTK2B1.61845236
13MAP3K21.55695757
14MAP3K41.51346835
15NEK61.48632788
16MAPK131.47085003
17PAK61.42619007
18MARK11.33134168
19NME11.30999687
20SIK21.22659876
21MAPKAPK31.17894709
22MINK11.15823221
23INSRR1.12304820
24OXSR11.10999120
25ACVR1B1.07206011
26TSSK61.06890446
27BCR1.06788576
28UHMK11.02830393
29STK380.98253598
30MARK20.96766956
31PLK20.95955238
32BMPR20.92158308
33PRKCH0.90954896
34CDK50.88186270
35SGK2230.87860209
36SGK4940.87860209
37MAP2K70.86811740
38CDK190.84626030
39NTRK20.84623134
40SGK10.84620564
41MAP3K70.81922732
42CASK0.81902698
43SGK20.81831846
44PINK10.80830918
45PRKCG0.79753181
46TTK0.78323073
47MAP4K20.77667140
48CAMK2A0.77323897
49STK240.72654190
50PDK10.72338269
51EEF2K0.71549555
52CAMKK20.68966686
53GRK10.67796875
54CAMK10.67370689
55PDPK10.66097540
56DYRK1A0.65180947
57ERBB20.64523848
58STK390.62643611
59MAP2K40.59511974
60PRKCI0.59288384
61BMPR1B0.58478202
62ARAF0.57114320
63CAMK2G0.56907194
64TNK20.53708854
65NTRK10.53165718
66ADRBK10.53031018
67STK110.51739499
68GRK50.50346683
69STK38L0.49302961
70PAK30.49298902
71MAPKAPK50.49254152
72PRKCQ0.47112330
73WNK40.44710703
74CAMK1G0.44592981
75DAPK10.44451354
76MAPK100.44181179
77MAPK120.43295506
78SGK30.42561070
79ADRBK20.41923339
80PRKCA0.40957050
81RPS6KA30.40934796
82FER0.40652006
83PRKCZ0.39652223
84CAMK2B0.37878782
85PHKG10.35374451
86PHKG20.35374451
87PRKACA0.34357488
88CSK0.34340477
89PRKCE0.32819094
90PRKCD0.30454140
91PRKG10.29969917
92PKN10.27972789
93ROCK20.27438394
94RET0.27077144
95KSR20.25750863
96TLK10.25669585
97FYN0.25652983
98MAP2K10.25007456
99STK100.24266477
100TRPM70.23006405

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46816747
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.24831657
3Histidine metabolism_Homo sapiens_hsa003403.19962159
4Phenylalanine metabolism_Homo sapiens_hsa003602.90069572
5Chemical carcinogenesis_Homo sapiens_hsa052042.63045354
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.59859740
7beta-Alanine metabolism_Homo sapiens_hsa004102.25398360
8Salivary secretion_Homo sapiens_hsa049702.19257950
9Synaptic vesicle cycle_Homo sapiens_hsa047212.16597215
10Tyrosine metabolism_Homo sapiens_hsa003502.01267757
11Amphetamine addiction_Homo sapiens_hsa050311.97159276
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.97038340
13Huntingtons disease_Homo sapiens_hsa050161.90236763
14Glutamatergic synapse_Homo sapiens_hsa047241.84583632
15Circadian entrainment_Homo sapiens_hsa047131.83414144
16GABAergic synapse_Homo sapiens_hsa047271.80047605
17Olfactory transduction_Homo sapiens_hsa047401.77719027
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77232774
19ABC transporters_Homo sapiens_hsa020101.76811838
20Insulin secretion_Homo sapiens_hsa049111.75273740
21Taste transduction_Homo sapiens_hsa047421.74915227
22Morphine addiction_Homo sapiens_hsa050321.68025942
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66748533
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50744336
25Cocaine addiction_Homo sapiens_hsa050301.49951461
26Calcium signaling pathway_Homo sapiens_hsa040201.49767878
27Gastric acid secretion_Homo sapiens_hsa049711.49443439
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48468096
29Long-term potentiation_Homo sapiens_hsa047201.41165234
30Phototransduction_Homo sapiens_hsa047441.40182602
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34517254
32Linoleic acid metabolism_Homo sapiens_hsa005911.28407590
33Dopaminergic synapse_Homo sapiens_hsa047281.27835170
34cAMP signaling pathway_Homo sapiens_hsa040241.25823488
35Caffeine metabolism_Homo sapiens_hsa002321.25753880
36Retinol metabolism_Homo sapiens_hsa008301.20508601
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17583207
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17009368
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16382332
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13899653
41Oxytocin signaling pathway_Homo sapiens_hsa049211.13136709
42Glutathione metabolism_Homo sapiens_hsa004801.08870238
43Serotonergic synapse_Homo sapiens_hsa047261.08763030
44Cholinergic synapse_Homo sapiens_hsa047251.07811287
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07348384
46Tight junction_Homo sapiens_hsa045301.02958466
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02702789
48Butanoate metabolism_Homo sapiens_hsa006501.00098208
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96970752
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96154502
51Circadian rhythm_Homo sapiens_hsa047100.94865134
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92232796
53Sphingolipid metabolism_Homo sapiens_hsa006000.90207886
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89925536
55Renin secretion_Homo sapiens_hsa049240.88819074
56Choline metabolism in cancer_Homo sapiens_hsa052310.80735911
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.80157847
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79727881
59Pancreatic secretion_Homo sapiens_hsa049720.79724402
60Fatty acid biosynthesis_Homo sapiens_hsa000610.77389912
61Estrogen signaling pathway_Homo sapiens_hsa049150.73509019
62Fatty acid degradation_Homo sapiens_hsa000710.69623092
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69041476
64Bile secretion_Homo sapiens_hsa049760.67836321
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.67212640
66Melanogenesis_Homo sapiens_hsa049160.64808624
67Type II diabetes mellitus_Homo sapiens_hsa049300.64438534
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64249432
69Peroxisome_Homo sapiens_hsa041460.64186847
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.63420369
71Collecting duct acid secretion_Homo sapiens_hsa049660.62830735
72GnRH signaling pathway_Homo sapiens_hsa049120.60899860
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.58550708
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55785455
75Thyroid hormone synthesis_Homo sapiens_hsa049180.55144888
76Long-term depression_Homo sapiens_hsa047300.54038630
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53440194
78Gap junction_Homo sapiens_hsa045400.51239092
79Nitrogen metabolism_Homo sapiens_hsa009100.50566901
80Arginine and proline metabolism_Homo sapiens_hsa003300.46539439
81Ovarian steroidogenesis_Homo sapiens_hsa049130.44609736
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42983136
83Arachidonic acid metabolism_Homo sapiens_hsa005900.42605319
84Cardiac muscle contraction_Homo sapiens_hsa042600.40176246
85Hedgehog signaling pathway_Homo sapiens_hsa043400.38902843
86Vitamin B6 metabolism_Homo sapiens_hsa007500.37118611
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.35668893
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.34967487
89Oocyte meiosis_Homo sapiens_hsa041140.34929043
90Glycerolipid metabolism_Homo sapiens_hsa005610.34105176
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33471877
92Axon guidance_Homo sapiens_hsa043600.32017302
93Hippo signaling pathway_Homo sapiens_hsa043900.30514458
94Tryptophan metabolism_Homo sapiens_hsa003800.30400455
95Starch and sucrose metabolism_Homo sapiens_hsa005000.27568656
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26102366
97Dilated cardiomyopathy_Homo sapiens_hsa054140.24534461
98ErbB signaling pathway_Homo sapiens_hsa040120.24049095
99Inositol phosphate metabolism_Homo sapiens_hsa005620.24006898
100PPAR signaling pathway_Homo sapiens_hsa033200.23979613

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