FRMPD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.73656025
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.07054066
3epithelial cilium movement (GO:0003351)9.01574976
4axoneme assembly (GO:0035082)7.33655380
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.90715634
6phosphorelay signal transduction system (GO:0000160)5.92237692
7left/right pattern formation (GO:0060972)5.80597739
8regulation of cilium movement (GO:0003352)5.23491317
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.99442384
10microtubule bundle formation (GO:0001578)4.95761172
11ventricular system development (GO:0021591)4.76799911
12left/right axis specification (GO:0070986)4.67305649
13one-carbon compound transport (GO:0019755)4.49548604
14cilium organization (GO:0044782)4.20917173
15cilium assembly (GO:0042384)4.14478021
16primary alcohol catabolic process (GO:0034310)4.07626976
17vocalization behavior (GO:0071625)4.03789287
18sperm capacitation (GO:0048240)3.96802644
19intraciliary transport (GO:0042073)3.87814911
20sperm motility (GO:0030317)3.84037240
21synaptic transmission, glutamatergic (GO:0035249)3.84005923
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.82481348
23synaptic vesicle maturation (GO:0016188)3.80022349
24centriole assembly (GO:0098534)3.79620789
25regulation of interleukin-5 production (GO:0032674)3.78552005
26microtubule-based movement (GO:0007018)3.75691855
27microtubule polymerization or depolymerization (GO:0031109)3.75441655
28diterpenoid biosynthetic process (GO:0016102)3.69132370
29regulation of interleukin-13 production (GO:0032656)3.66688718
30histone H4-K12 acetylation (GO:0043983)3.63640942
31calcium ion-dependent exocytosis (GO:0017156)3.60583635
32regulation of neuronal synaptic plasticity (GO:0048168)3.57909132
33vitamin transmembrane transport (GO:0035461)3.57449777
34locomotory exploration behavior (GO:0035641)3.52126947
35protein localization to cilium (GO:0061512)3.50610639
36neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.48192897
37ethanol metabolic process (GO:0006067)3.46932193
38glutamate receptor signaling pathway (GO:0007215)3.46757042
39protein localization to synapse (GO:0035418)3.41535513
40negative regulation of immunoglobulin mediated immune response (GO:0002890)3.39972586
41negative regulation of B cell mediated immunity (GO:0002713)3.39972586
42regulation of glutamate receptor signaling pathway (GO:1900449)3.39879134
43protein polyglutamylation (GO:0018095)3.39770898
44regulation of synaptic vesicle transport (GO:1902803)3.37807496
45serotonin metabolic process (GO:0042428)3.36448681
46glomerular epithelial cell development (GO:0072310)3.36006369
47myoblast fusion (GO:0007520)3.35736709
48regulation of microtubule-based movement (GO:0060632)3.34447817
49primary amino compound metabolic process (GO:1901160)3.34210755
50cellular component assembly involved in morphogenesis (GO:0010927)3.31761308
51negative regulation of inclusion body assembly (GO:0090084)3.29697481
52retinoic acid metabolic process (GO:0042573)3.25929864
53cytoplasmic microtubule organization (GO:0031122)3.24874357
54phenol-containing compound catabolic process (GO:0019336)3.21979295
55exploration behavior (GO:0035640)3.21463259
56glutamate secretion (GO:0014047)3.21130445
57neuronal action potential (GO:0019228)3.19968051
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17044281
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13899152
60neuron-neuron synaptic transmission (GO:0007270)3.10880039
61peripheral nervous system development (GO:0007422)3.09682753
62synaptic vesicle exocytosis (GO:0016079)3.09377384
63cell projection assembly (GO:0030031)3.07084096
64membrane depolarization during action potential (GO:0086010)3.05590155
65regulation of neuron projection regeneration (GO:0070570)3.02797827
66regulation of axon regeneration (GO:0048679)3.02797827
67microtubule depolymerization (GO:0007019)3.01266071
68response to xenobiotic stimulus (GO:0009410)2.97509693
69righting reflex (GO:0060013)2.94307103
70regulation of ARF protein signal transduction (GO:0032012)2.91795598
71syncytium formation by plasma membrane fusion (GO:0000768)2.91752235
72hydrogen peroxide biosynthetic process (GO:0050665)2.90090119
73regulation of synaptic vesicle exocytosis (GO:2000300)2.90025260
74acrosome reaction (GO:0007340)2.88359628
75neurotransmitter catabolic process (GO:0042135)2.85569796
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83865640
77regulation of type B pancreatic cell apoptotic process (GO:2000674)2.80919452
78neurotransmitter secretion (GO:0007269)2.77476739
79ADP metabolic process (GO:0046031)2.75815321
80regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72277185
81aldehyde catabolic process (GO:0046185)2.71221186
82sodium ion transmembrane transport (GO:0035725)2.70110322
83alanine transport (GO:0032328)2.70002141
84lung epithelium development (GO:0060428)2.69644652
85nucleoside diphosphate phosphorylation (GO:0006165)2.69378222
86cilium morphogenesis (GO:0060271)2.65426340
87flavonoid metabolic process (GO:0009812)2.62291916
88negative regulation of sodium ion transport (GO:0010766)2.61034183
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60817985
90appendage development (GO:0048736)2.58095334
91limb development (GO:0060173)2.58095334
92reactive oxygen species biosynthetic process (GO:1903409)2.55414718
93establishment or maintenance of monopolar cell polarity (GO:0061339)2.54875881
94establishment of monopolar cell polarity (GO:0061162)2.54875881
95establishment of apical/basal cell polarity (GO:0035089)2.54754726
96regulation of synaptic plasticity (GO:0048167)2.54213344
97retinal cone cell development (GO:0046549)2.52941272
98axonemal dynein complex assembly (GO:0070286)13.8135332
99cilium or flagellum-dependent cell motility (GO:0001539)13.4264101
100cilium movement (GO:0003341)10.6474322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69309306
2DROSHA_22980978_ChIP-Seq_HELA_Human3.83856331
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99762549
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.99703942
5GBX2_23144817_ChIP-Seq_PC3_Human2.42487551
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13773808
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.08643140
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02211684
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.00930714
10REST_21632747_ChIP-Seq_MESCs_Mouse2.00502061
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91230499
12AR_21572438_ChIP-Seq_LNCaP_Human1.88209799
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86551408
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81903979
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81096370
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75591425
17TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.74975941
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74946174
19SMAD3_21741376_ChIP-Seq_EPCs_Human1.73013419
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68471865
21SMAD4_21799915_ChIP-Seq_A2780_Human1.66999334
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65661260
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54478572
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54277134
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53185682
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.50995373
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45818826
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.45061329
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.44152610
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44136210
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41992432
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41653639
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41505286
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40455616
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40375201
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39954245
37SMAD3_21741376_ChIP-Seq_HESCs_Human1.38156111
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37908610
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.37506743
40STAT3_23295773_ChIP-Seq_U87_Human1.34397361
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33340615
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.33218542
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32426475
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32018826
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.30366609
46SMAD4_21741376_ChIP-Seq_HESCs_Human1.30127689
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29358463
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28950270
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28626375
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28571576
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28571576
52YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26231694
53VDR_22108803_ChIP-Seq_LS180_Human1.26029177
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.25391507
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23657581
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23193615
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23193615
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22157351
59TCF4_23295773_ChIP-Seq_U87_Human1.18334553
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18291209
61TP53_18474530_ChIP-ChIP_U2OS_Human1.18248470
62GATA1_19941826_ChIP-Seq_K562_Human1.16946225
63KLF5_25053715_ChIP-Seq_YYC3_Human1.11366738
64RUNX2_22187159_ChIP-Seq_PCA_Human1.11156451
65ETV1_20927104_ChIP-Seq_GIST48_Human1.10839093
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09328841
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07591681
68AR_25329375_ChIP-Seq_VCAP_Human1.07515308
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07325175
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07069131
71AHR_22903824_ChIP-Seq_MCF-7_Human1.07004196
72AR_19668381_ChIP-Seq_PC3_Human1.06692899
73RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06425997
74CTCF_27219007_Chip-Seq_Bcells_Human1.06286041
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.05580618
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05052846
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04648977
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01788599
79TBL1_22424771_ChIP-Seq_293T_Human0.98449635
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97934950
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97531197
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.97025093
83TP63_23658742_ChIP-Seq_EP156T_Human0.97005494
84TCF4_22108803_ChIP-Seq_LS180_Human0.96530631
85RNF2_27304074_Chip-Seq_NSC_Mouse0.96095322
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.96012960
87SMC4_20622854_ChIP-Seq_HELA_Human0.95479719
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95383586
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94539611
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94520277
91SMRT_27268052_Chip-Seq_Bcells_Human0.94390202
92CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94090090
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94021189
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.91678391
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.91650031
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91014104
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90326331
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.89983420
99NFYB_21822215_ChIP-Seq_K562_Human0.89346130
100FUS_26573619_Chip-Seq_HEK293_Human0.89195255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.64239259
2MP0004270_analgesia4.37470629
3MP0003880_abnormal_central_pattern3.96386152
4MP0002822_catalepsy3.78716280
5MP0009046_muscle_twitch3.33048856
6MP0002653_abnormal_ependyma_morphology3.28979913
7MP0002734_abnormal_mechanical_nocicepti3.18381510
8MP0005423_abnormal_somatic_nervous3.16520685
9MP0003635_abnormal_synaptic_transmissio3.12112986
10MP0001486_abnormal_startle_reflex3.09601603
11MP0008875_abnormal_xenobiotic_pharmacok3.06796062
12MP0009745_abnormal_behavioral_response2.92116358
13MP0002064_seizures2.85398687
14MP0001968_abnormal_touch/_nociception2.73240011
15MP0002735_abnormal_chemical_nociception2.59654414
16MP0005646_abnormal_pituitary_gland2.49935107
17MP0002277_abnormal_respiratory_mucosa2.39263921
18MP0004043_abnormal_pH_regulation2.38484452
19MP0001984_abnormal_olfaction2.36970564
20MP0009780_abnormal_chondrocyte_physiolo2.27469090
21MP0002272_abnormal_nervous_system2.26797601
22MP0002572_abnormal_emotion/affect_behav2.22290880
23MP0002063_abnormal_learning/memory/cond2.20411979
24MP0005623_abnormal_meninges_morphology2.14159858
25MP0001346_abnormal_lacrimal_gland2.08802087
26MP0002733_abnormal_thermal_nociception1.92425749
27MP0005248_abnormal_Harderian_gland1.86541780
28MP0004133_heterotaxia1.85899556
29MP0001970_abnormal_pain_threshold1.82061446
30MP0001485_abnormal_pinna_reflex1.77177693
31MP0002132_abnormal_respiratory_system1.67558665
32MP0003633_abnormal_nervous_system1.67533030
33MP0001501_abnormal_sleep_pattern1.59115581
34MP0003890_abnormal_embryonic-extraembry1.52948590
35MP0002067_abnormal_sensory_capabilities1.49037282
36MP0005410_abnormal_fertilization1.48016002
37MP0003879_abnormal_hair_cell1.45055388
38MP0003631_nervous_system_phenotype1.44484708
39MP0004924_abnormal_behavior1.37143846
40MP0005386_behavior/neurological_phenoty1.37143846
41MP0002736_abnormal_nociception_after1.34954980
42MP0008872_abnormal_physiological_respon1.27551980
43MP0003656_abnormal_erythrocyte_physiolo1.27450595
44MP0004742_abnormal_vestibular_system1.23386097
45MP0003698_abnormal_male_reproductive1.21217379
46MP0001765_abnormal_ion_homeostasis1.20556016
47MP0003329_amyloid_beta_deposits1.19608959
48MP0002557_abnormal_social/conspecific_i1.16419421
49MP0002089_abnormal_postnatal_growth/wei1.14068048
50MP0000955_abnormal_spinal_cord1.12375178
51MP0005551_abnormal_eye_electrophysiolog1.11936987
52MP0000566_synostosis1.11709111
53MP0008569_lethality_at_weaning1.11570528
54MP0005377_hearing/vestibular/ear_phenot1.08734492
55MP0003878_abnormal_ear_physiology1.08734492
56MP0001440_abnormal_grooming_behavior1.07859527
57MP0002882_abnormal_neuron_morphology1.06259944
58MP0002282_abnormal_trachea_morphology1.04768134
59MP0005499_abnormal_olfactory_system1.04692772
60MP0005394_taste/olfaction_phenotype1.04692772
61MP0004147_increased_porphyrin_level1.04450300
62MP0008789_abnormal_olfactory_epithelium1.04176055
63MP0004811_abnormal_neuron_physiology1.02745821
64MP0002229_neurodegeneration1.02192481
65MP0005645_abnormal_hypothalamus_physiol1.01877094
66MP0002066_abnormal_motor_capabilities/c0.99403696
67MP0001502_abnormal_circadian_rhythm0.98717393
68MP0001963_abnormal_hearing_physiology0.98261134
69MP0002638_abnormal_pupillary_reflex0.93397325
70MP0001929_abnormal_gametogenesis0.91567559
71MP0003632_abnormal_nervous_system0.87779977
72MP0002090_abnormal_vision0.84242202
73MP0003690_abnormal_glial_cell0.80384580
74MP0002184_abnormal_innervation0.79429038
75MP0002152_abnormal_brain_morphology0.79329096
76MP0002069_abnormal_eating/drinking_beha0.78206136
77MP0000778_abnormal_nervous_system0.76862056
78MP0003303_peritoneal_inflammation0.76355003
79MP0000751_myopathy0.72238845
80MP0001348_abnormal_lacrimal_gland0.71817732
81MP0002168_other_aberrant_phenotype0.70331172
82MP0002249_abnormal_larynx_morphology0.70005659
83MP0001905_abnormal_dopamine_level0.69959835
84MP0003861_abnormal_nervous_system0.65382177
85MP0002909_abnormal_adrenal_gland0.64723839
86MP0002161_abnormal_fertility/fecundity0.63753032
87MP0008961_abnormal_basal_metabolism0.62729221
88MP0006276_abnormal_autonomic_nervous0.62483519
89MP0001664_abnormal_digestion0.61372758
90MP0000026_abnormal_inner_ear0.59766321
91MP0005083_abnormal_biliary_tract0.58372997
92MP0008874_decreased_physiological_sensi0.58276888
93MP0005636_abnormal_mineral_homeostasis0.57724271
94MP0000383_abnormal_hair_follicle0.56063920
95MP0003956_abnormal_body_size0.53665141
96MP0000920_abnormal_myelination0.52773984
97MP0002160_abnormal_reproductive_system0.52466572
98MP0005395_other_phenotype0.51328256
99MP0004145_abnormal_muscle_electrophysio0.50650884
100MP0010770_preweaning_lethality0.48045572

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.88635008
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.62630676
3Absent/shortened dynein arms (HP:0200106)9.62630676
4Abnormal respiratory epithelium morphology (HP:0012253)9.58174632
5Abnormal respiratory motile cilium morphology (HP:0005938)9.58174632
6Abnormal ciliary motility (HP:0012262)9.31464689
7Rhinitis (HP:0012384)9.00097399
8Chronic bronchitis (HP:0004469)7.13164238
9Bronchiectasis (HP:0002110)6.29205440
10Nasal polyposis (HP:0100582)5.71755772
11Abnormality of the nasal mucosa (HP:0000433)4.65248351
12Infertility (HP:0000789)3.85556864
13Bronchitis (HP:0012387)3.77111727
14Recurrent sinusitis (HP:0011108)3.73510374
15Male infertility (HP:0003251)3.42920958
16Recurrent otitis media (HP:0000403)3.38392227
17Pancreatic fibrosis (HP:0100732)3.37498903
18Focal motor seizures (HP:0011153)3.34133297
19True hermaphroditism (HP:0010459)3.31079788
20Chronic sinusitis (HP:0011109)3.09211285
21Nephronophthisis (HP:0000090)2.89625414
22Cystic liver disease (HP:0006706)2.76879369
23Pancreatic cysts (HP:0001737)2.75333414
24Chronic otitis media (HP:0000389)2.70298576
25Hyperactive renin-angiotensin system (HP:0000841)2.69809148
26Bell-shaped thorax (HP:0001591)2.64494376
27Occipital encephalocele (HP:0002085)2.61775455
28Myokymia (HP:0002411)2.59324655
29Medial flaring of the eyebrow (HP:0010747)2.54668229
30Gait imbalance (HP:0002141)2.44432329
31Atelectasis (HP:0100750)2.41392045
32Ventricular fibrillation (HP:0001663)2.33996721
33Epileptic encephalopathy (HP:0200134)2.30106081
34Abnormality of midbrain morphology (HP:0002418)2.26487913
35Molar tooth sign on MRI (HP:0002419)2.26487913
36Congenital primary aphakia (HP:0007707)2.22547642
37Nephrogenic diabetes insipidus (HP:0009806)2.21602077
38Slender build (HP:0001533)2.16095889
39Postaxial foot polydactyly (HP:0001830)2.12249845
40Abnormality of the renal medulla (HP:0100957)2.09137550
41Focal seizures (HP:0007359)2.02763691
42Congenital hepatic fibrosis (HP:0002612)2.00547220
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7724397
44Amblyopia (HP:0000646)1.96551911
45Chronic hepatic failure (HP:0100626)1.95439601
46Tubulointerstitial nephritis (HP:0001970)1.93522800
47Aplasia/Hypoplasia of the tongue (HP:0010295)1.86274636
48Anencephaly (HP:0002323)1.84765352
49Sclerocornea (HP:0000647)1.83550182
50Tubular atrophy (HP:0000092)1.82192832
51Furrowed tongue (HP:0000221)1.81185236
52Poor coordination (HP:0002370)1.79497429
53Autoamputation (HP:0001218)1.75846897
54Self-mutilation (HP:0000742)1.70885295
55Gaze-evoked nystagmus (HP:0000640)1.69920934
56Male pseudohermaphroditism (HP:0000037)1.67437237
57Progressive cerebellar ataxia (HP:0002073)1.62709590
58Renal salt wasting (HP:0000127)1.61629337
59Hyperkalemia (HP:0002153)1.61102559
60Osteomalacia (HP:0002749)1.60502398
61Ankle clonus (HP:0011448)1.60314187
62Anhidrosis (HP:0000970)1.57636058
63Genital tract atresia (HP:0001827)1.53973597
64Fetal akinesia sequence (HP:0001989)1.53248491
65Vaginal atresia (HP:0000148)1.52930972
66Hand muscle atrophy (HP:0009130)1.50772216
67Recurrent bronchitis (HP:0002837)1.46075625
68Febrile seizures (HP:0002373)1.45586129
69Postaxial hand polydactyly (HP:0001162)1.45306942
70Pheochromocytoma (HP:0002666)1.43320425
71Torticollis (HP:0000473)1.42784006
72Alveolar cell carcinoma (HP:0006519)1.41983796
73Oculomotor apraxia (HP:0000657)1.41907923
74Hyperaldosteronism (HP:0000859)1.38987800
75Increased number of teeth (HP:0011069)1.38407886
76Asplenia (HP:0001746)1.36895487
77Inability to walk (HP:0002540)1.35383989
78Type II lissencephaly (HP:0007260)1.35153854
79Absent speech (HP:0001344)1.32241363
80Tubulointerstitial abnormality (HP:0001969)1.31945805
81Generalized tonic-clonic seizures (HP:0002069)1.31376332
82Truncal ataxia (HP:0002078)1.30764926
83Prominent supraorbital ridges (HP:0000336)1.30697258
84Preaxial hand polydactyly (HP:0001177)1.29048417
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.28329949
86Abnormality of renin-angiotensin system (HP:0000847)1.27857750
87Postural instability (HP:0002172)1.27076148
88Nephropathy (HP:0000112)1.26804772
89Neoplasm of the tracheobronchial system (HP:0100552)1.23945932
90Drooling (HP:0002307)1.23018802
91Specific learning disability (HP:0001328)1.22796494
92Relative macrocephaly (HP:0004482)1.22733395
93Abnormality of abdominal situs (HP:0011620)1.22085775
94Abdominal situs inversus (HP:0003363)1.22085775
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21891167
96Decreased circulating renin level (HP:0003351)1.21636288
97Obstructive sleep apnea (HP:0002870)1.20842638
98Abnormality of chloride homeostasis (HP:0011422)1.20830431
99Absent frontal sinuses (HP:0002688)1.20820439
100Neuroendocrine neoplasm (HP:0100634)1.19937105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.74459480
2STK244.51555631
3EPHA44.28678637
4PRKD32.87611179
5RIPK42.66384003
6PNCK2.45735742
7NTRK32.34712856
8DAPK22.32539696
9NTRK12.29386479
10MAPKAPK32.02738176
11MAP4K22.01923832
12EEF2K1.96451049
13EPHA21.80010438
14MST41.79597725
15SIK21.75775035
16MAPK131.73183732
17PAK61.67029356
18CDK191.60859715
19MAP3K131.59731321
20CAMKK11.47413476
21MINK11.47068393
22DAPK11.39170414
23MARK11.25475547
24NME11.25249384
25UHMK11.23207299
26PTK2B1.16386693
27STK31.13693140
28MAP3K41.12916570
29MAP3K21.07943130
30PLK41.07005952
31ACVR1B1.05376516
32ADRBK11.01690537
33NEK61.00082904
34MAP3K70.99973003
35PRKCG0.95566961
36PINK10.95368074
37CDK50.93650412
38SGK20.91380529
39SIK10.90961140
40CCNB10.90287607
41OXSR10.87162692
42MARK20.86640813
43SGK10.86572782
44BMPR1B0.86022897
45SGK2230.85380705
46SGK4940.85380705
47PDK10.83787720
48MAP2K40.81707709
49ARAF0.77530025
50CAMK10.77107263
51CAMK1G0.77020300
52ERBB20.76900801
53MAP2K70.75776306
54GRK50.75401444
55TRPM70.74733360
56CAMK2A0.72248616
57PDPK10.71106875
58STK380.69769512
59PLK20.69131795
60FRK0.66401027
61DYRK1A0.62608444
62PRKCH0.62266908
63CAMK2B0.62057630
64ICK0.59369541
65STK110.59066977
66RPS6KA20.58178546
67IRAK10.57833529
68MAPKAPK50.57392185
69MATK0.56486241
70SGK30.56467623
71MAP3K110.56136478
72NTRK20.55185611
73IRAK20.55033792
74TAOK10.54972481
75MAP3K30.52044341
76INSRR0.50712413
77TESK10.50343596
78PRKCQ0.49169210
79BCR0.48839455
80TAOK30.46839171
81CAMK2G0.46197268
82TTK0.45745593
83MST1R0.45677794
84PAK30.45393786
85PKN20.45196230
86CDK30.44985788
87MAPK120.44798017
88PRKCZ0.44341213
89CSNK1G20.43591079
90CHUK0.43313076
91BRD40.43032497
92AKT20.42690168
93LATS20.40510178
94MAP2K10.39347407
95KSR20.38937365
96RPS6KA30.38148398
97PRKAA20.37668204
98PRKCA0.36699849
99PRKAA10.33958403
100STK100.30767585

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.63917478
2Phenylalanine metabolism_Homo sapiens_hsa003602.93482205
3Amphetamine addiction_Homo sapiens_hsa050312.72020039
4Glutamatergic synapse_Homo sapiens_hsa047242.58714383
5Circadian entrainment_Homo sapiens_hsa047132.50492685
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.46726629
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41427077
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.32150695
9Salivary secretion_Homo sapiens_hsa049702.28354069
10Histidine metabolism_Homo sapiens_hsa003402.21842346
11Synaptic vesicle cycle_Homo sapiens_hsa047212.21157004
12Olfactory transduction_Homo sapiens_hsa047402.08846619
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05257327
14Long-term potentiation_Homo sapiens_hsa047202.02072098
15Chemical carcinogenesis_Homo sapiens_hsa052041.97574954
16Taste transduction_Homo sapiens_hsa047421.92483415
17Long-term depression_Homo sapiens_hsa047301.84651009
18Dopaminergic synapse_Homo sapiens_hsa047281.83024392
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76631055
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71878379
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.71041724
22Gastric acid secretion_Homo sapiens_hsa049711.67407350
23Tyrosine metabolism_Homo sapiens_hsa003501.67200507
24GABAergic synapse_Homo sapiens_hsa047271.61872080
25Morphine addiction_Homo sapiens_hsa050321.57832324
26Calcium signaling pathway_Homo sapiens_hsa040201.56600830
27Insulin secretion_Homo sapiens_hsa049111.52743713
28Cholinergic synapse_Homo sapiens_hsa047251.48990265
29Cocaine addiction_Homo sapiens_hsa050301.46205265
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45892571
31Oxytocin signaling pathway_Homo sapiens_hsa049211.41571703
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36763168
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32860444
34Dorso-ventral axis formation_Homo sapiens_hsa043201.26547324
35Serotonergic synapse_Homo sapiens_hsa047261.25111902
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18386694
37Renin secretion_Homo sapiens_hsa049241.15908282
38cAMP signaling pathway_Homo sapiens_hsa040241.13732343
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12689866
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06444212
41Sphingolipid metabolism_Homo sapiens_hsa006001.02261048
42Retinol metabolism_Homo sapiens_hsa008300.97101533
43Huntingtons disease_Homo sapiens_hsa050160.94348478
44beta-Alanine metabolism_Homo sapiens_hsa004100.94171505
45Sphingolipid signaling pathway_Homo sapiens_hsa040710.88352814
46Caffeine metabolism_Homo sapiens_hsa002320.86698244
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86118685
48Linoleic acid metabolism_Homo sapiens_hsa005910.80760306
49Estrogen signaling pathway_Homo sapiens_hsa049150.79380113
50ABC transporters_Homo sapiens_hsa020100.78968746
51Type II diabetes mellitus_Homo sapiens_hsa049300.78344519
52Starch and sucrose metabolism_Homo sapiens_hsa005000.76971782
53Pancreatic secretion_Homo sapiens_hsa049720.76316030
54Melanogenesis_Homo sapiens_hsa049160.73926123
55Asthma_Homo sapiens_hsa053100.72737755
56Tight junction_Homo sapiens_hsa045300.72117554
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72044515
58Fatty acid biosynthesis_Homo sapiens_hsa000610.69538463
59Choline metabolism in cancer_Homo sapiens_hsa052310.69138131
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68790016
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63113876
62Vitamin B6 metabolism_Homo sapiens_hsa007500.61654558
63GnRH signaling pathway_Homo sapiens_hsa049120.60616218
64Cardiac muscle contraction_Homo sapiens_hsa042600.59350873
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56858041
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55604910
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.55478657
68MAPK signaling pathway_Homo sapiens_hsa040100.55178263
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.52696938
70Phototransduction_Homo sapiens_hsa047440.52327494
71Thyroid hormone synthesis_Homo sapiens_hsa049180.51280533
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.49408178
73Rap1 signaling pathway_Homo sapiens_hsa040150.49337084
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.48666076
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46790785
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46563967
77Oocyte meiosis_Homo sapiens_hsa041140.46064287
78Glutathione metabolism_Homo sapiens_hsa004800.43804958
79Axon guidance_Homo sapiens_hsa043600.42634127
80Bile secretion_Homo sapiens_hsa049760.42298523
81Arginine and proline metabolism_Homo sapiens_hsa003300.41509798
82Type I diabetes mellitus_Homo sapiens_hsa049400.41360518
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41135098
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.40099831
85Inositol phosphate metabolism_Homo sapiens_hsa005620.39208688
86Gap junction_Homo sapiens_hsa045400.37597191
87mTOR signaling pathway_Homo sapiens_hsa041500.35888642
88African trypanosomiasis_Homo sapiens_hsa051430.34112035
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32886909
90Ras signaling pathway_Homo sapiens_hsa040140.32396178
91Endocytosis_Homo sapiens_hsa041440.32027148
92Hippo signaling pathway_Homo sapiens_hsa043900.31962107
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31623958
94VEGF signaling pathway_Homo sapiens_hsa043700.31436859
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27781201
96Butanoate metabolism_Homo sapiens_hsa006500.26502505
97Wnt signaling pathway_Homo sapiens_hsa043100.24097875
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23882316
99Dilated cardiomyopathy_Homo sapiens_hsa054140.23721695
100Glucagon signaling pathway_Homo sapiens_hsa049220.23117421

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