FRMPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20577807
2vocalization behavior (GO:0071625)5.88128292
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.85975325
4synaptic vesicle maturation (GO:0016188)5.83185698
5locomotory exploration behavior (GO:0035641)5.78553679
6synaptic vesicle exocytosis (GO:0016079)5.61485481
7glutamate secretion (GO:0014047)5.43519511
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38602502
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32171074
10regulation of glutamate receptor signaling pathway (GO:1900449)5.10758817
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.01214226
12regulation of synaptic vesicle exocytosis (GO:2000300)4.98058524
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.88514166
14protein localization to synapse (GO:0035418)4.83290156
15neuronal action potential propagation (GO:0019227)4.74935727
16neuron cell-cell adhesion (GO:0007158)4.66018005
17exploration behavior (GO:0035640)4.62569649
18neurotransmitter secretion (GO:0007269)4.60365405
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.58089506
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.55696554
21regulation of synaptic vesicle transport (GO:1902803)4.47556467
22regulation of neuronal synaptic plasticity (GO:0048168)4.45773029
23synaptic transmission, glutamatergic (GO:0035249)4.44048992
24glutamate receptor signaling pathway (GO:0007215)4.42375727
25neurotransmitter-gated ion channel clustering (GO:0072578)4.34707632
26neuron-neuron synaptic transmission (GO:0007270)4.31490442
27L-amino acid import (GO:0043092)4.25131508
28gamma-aminobutyric acid transport (GO:0015812)4.19951352
29layer formation in cerebral cortex (GO:0021819)4.06773285
30long-term memory (GO:0007616)4.02997865
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.02678940
32proline transport (GO:0015824)3.97247480
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.94645014
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93318527
35positive regulation of membrane potential (GO:0045838)3.91659981
36positive regulation of synapse maturation (GO:0090129)3.90880546
37regulation of postsynaptic membrane potential (GO:0060078)3.81269049
38negative regulation of dendrite morphogenesis (GO:0050774)3.79466860
39dendritic spine morphogenesis (GO:0060997)3.77523582
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.74575098
41regulation of voltage-gated calcium channel activity (GO:1901385)3.74115080
42regulation of synaptic plasticity (GO:0048167)3.73542390
43cellular potassium ion homeostasis (GO:0030007)3.71225808
44detection of calcium ion (GO:0005513)3.71168815
45neurotransmitter transport (GO:0006836)3.70334439
46amino acid import (GO:0043090)3.69831365
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65726917
48* regulation of synapse structural plasticity (GO:0051823)3.65317336
49serotonin metabolic process (GO:0042428)3.60724366
50positive regulation of dendritic spine development (GO:0060999)3.60668801
51long-term synaptic potentiation (GO:0060291)3.59559855
52transmission of nerve impulse (GO:0019226)3.57717626
53cerebellar Purkinje cell differentiation (GO:0021702)3.56602604
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.56274042
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.54936098
56potassium ion homeostasis (GO:0055075)3.53799812
57neuron recognition (GO:0008038)3.52721491
58regulation of dendritic spine morphogenesis (GO:0061001)3.52428048
59cellular sodium ion homeostasis (GO:0006883)3.51681916
60activation of protein kinase A activity (GO:0034199)3.48955256
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.48898919
62postsynaptic membrane organization (GO:0001941)3.46827261
63regulation of neurotransmitter levels (GO:0001505)3.45455624
64pyrimidine nucleobase catabolic process (GO:0006208)3.44656888
65regulation of neurotransmitter secretion (GO:0046928)3.41078609
66neuromuscular process controlling balance (GO:0050885)3.40513061
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39215165
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37788588
69synaptic vesicle endocytosis (GO:0048488)3.37682108
70response to histamine (GO:0034776)3.37197100
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35452135
72neuronal ion channel clustering (GO:0045161)3.31770962
73behavioral defense response (GO:0002209)3.31540189
74behavioral fear response (GO:0001662)3.31540189
75presynaptic membrane assembly (GO:0097105)3.31408525
76auditory behavior (GO:0031223)3.31035120
77axonal fasciculation (GO:0007413)3.29142855
78sodium ion export (GO:0071436)3.29086879
79potassium ion import (GO:0010107)3.24061357
80membrane depolarization (GO:0051899)3.23164466
81response to auditory stimulus (GO:0010996)3.22634475
82cerebellar granule cell differentiation (GO:0021707)3.20083836
83regulation of neurotransmitter transport (GO:0051588)3.18610006
84positive regulation of neurotransmitter transport (GO:0051590)3.17872399
85regulation of vesicle fusion (GO:0031338)3.17267810
86learning (GO:0007612)3.17161510
87neuromuscular process controlling posture (GO:0050884)3.16236778
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15691958
89positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14445235
90positive regulation of neurotransmitter secretion (GO:0001956)3.14086993
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13765150
92synapse assembly (GO:0007416)3.13346869
93primary amino compound metabolic process (GO:1901160)3.11062731
94response to amphetamine (GO:0001975)3.10920868
95membrane hyperpolarization (GO:0060081)3.10726957
96membrane depolarization during action potential (GO:0086010)3.10069987
97nucleobase catabolic process (GO:0046113)3.09013229
98cell differentiation in hindbrain (GO:0021533)3.08772638
99fear response (GO:0042596)3.08747104
100dendrite morphogenesis (GO:0048813)3.08141419
101central nervous system myelination (GO:0022010)3.08132062
102axon ensheathment in central nervous system (GO:0032291)3.08132062
103presynaptic membrane organization (GO:0097090)3.07488583
104regulation of synaptic transmission (GO:0050804)3.07334361
105synaptic transmission (GO:0007268)3.07188009
106regulation of synapse maturation (GO:0090128)3.06711488
107innervation (GO:0060384)3.05094821
108intraspecies interaction between organisms (GO:0051703)3.05043304
109social behavior (GO:0035176)3.05043304
110positive regulation of synaptic transmission (GO:0050806)3.04074037
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04005754
112regulation of ARF protein signal transduction (GO:0032012)3.03921436
113neuromuscular process (GO:0050905)3.03454833
114establishment of synaptic vesicle localization (GO:0097480)3.02816438
115synaptic vesicle transport (GO:0048489)3.02816438
116startle response (GO:0001964)3.02742126
117behavioral response to cocaine (GO:0048148)3.02686896
118regulation of dendritic spine development (GO:0060998)3.02133585
119vesicle transport along microtubule (GO:0047496)3.00901491
120long term synaptic depression (GO:0060292)3.00889979
121central nervous system projection neuron axonogenesis (GO:0021952)2.99137595
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97273946
123prepulse inhibition (GO:0060134)2.96252736
124cell communication by electrical coupling (GO:0010644)2.94644579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13335047
2GBX2_23144817_ChIP-Seq_PC3_Human3.77332105
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18875585
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13051737
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08991657
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72880510
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72880510
8REST_21632747_ChIP-Seq_MESCs_Mouse2.67804839
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65502578
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58187862
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.54050763
12DROSHA_22980978_ChIP-Seq_HELA_Human2.50957418
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50888076
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50208893
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48859286
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47525683
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40575606
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.21322480
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.18523336
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16329184
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15966112
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.15810947
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09293059
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02583690
25AR_21572438_ChIP-Seq_LNCaP_Human1.99749030
26TAF15_26573619_Chip-Seq_HEK293_Human1.92013993
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91930545
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91583114
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90961185
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87965107
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85366542
32SMAD4_21799915_ChIP-Seq_A2780_Human1.76992711
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76581120
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71955011
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66687766
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54530533
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.52544157
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.49011006
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47742487
40* P300_19829295_ChIP-Seq_ESCs_Human1.45825901
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42195648
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.36921919
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.35732124
44AR_25329375_ChIP-Seq_VCAP_Human1.34329315
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32968388
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32493806
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30140737
48ZNF274_21170338_ChIP-Seq_K562_Hela1.29989082
49STAT3_23295773_ChIP-Seq_U87_Human1.29573189
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28375642
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28097525
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26499260
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25841332
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.23539537
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23414875
56* AR_19668381_ChIP-Seq_PC3_Human1.23317248
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22767929
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.22739597
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19816592
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17676895
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16950626
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15626969
63* CBX2_27304074_Chip-Seq_ESCs_Mouse1.15305745
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13978959
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13961744
66* TCF4_23295773_ChIP-Seq_U87_Human1.13569370
67IGF1R_20145208_ChIP-Seq_DFB_Human1.12692401
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12300151
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.12235162
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11914032
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11699859
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11455447
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09598078
74RNF2_27304074_Chip-Seq_NSC_Mouse1.09066380
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08282678
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07673003
77AHR_22903824_ChIP-Seq_MCF-7_Human1.07072388
78FUS_26573619_Chip-Seq_HEK293_Human1.06997665
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06637756
80KDM2B_26808549_Chip-Seq_REH_Human1.05336658
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04965799
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.04287059
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04221888
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03620561
85TP53_16413492_ChIP-PET_HCT116_Human1.02790990
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02688155
87SOX9_26525672_Chip-Seq_HEART_Mouse1.02458407
88RUNX2_22187159_ChIP-Seq_PCA_Human1.00699802
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99939701
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99796063
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.98978339
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.98155401
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97899651
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96527168
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96348379
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.95481395
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94043077
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93561077
99TP53_18474530_ChIP-ChIP_U2OS_Human0.93216978
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.92683723
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92503959
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.92187759
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91679032
104RXR_22108803_ChIP-Seq_LS180_Human0.91651747
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91094702
106BCAT_22108803_ChIP-Seq_LS180_Human0.90633776
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89515074
108JUN_21703547_ChIP-Seq_K562_Human0.89443617
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.89222083
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88797022
111KDM2B_26808549_Chip-Seq_K562_Human0.88683690
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.88291999
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87987169
114ER_23166858_ChIP-Seq_MCF-7_Human0.87564835
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.87088361
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87086512
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86617240
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86605116
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86112331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73509811
2MP0003880_abnormal_central_pattern4.63331396
3MP0003635_abnormal_synaptic_transmissio4.32184177
4MP0004270_analgesia3.73055058
5MP0009745_abnormal_behavioral_response3.65241803
6MP0002063_abnormal_learning/memory/cond3.51414982
7MP0009046_muscle_twitch3.41694743
8MP0002064_seizures3.33332043
9MP0001968_abnormal_touch/_nociception3.07925723
10MP0002572_abnormal_emotion/affect_behav2.97936250
11MP0002822_catalepsy2.78344724
12MP0002734_abnormal_mechanical_nocicepti2.76178541
13MP0002272_abnormal_nervous_system2.73710384
14MP0001501_abnormal_sleep_pattern2.65509339
15MP0001486_abnormal_startle_reflex2.60100392
16MP0005423_abnormal_somatic_nervous2.56178382
17MP0002735_abnormal_chemical_nociception2.38443073
18MP0002736_abnormal_nociception_after2.36774057
19MP0001440_abnormal_grooming_behavior2.27248103
20MP0009780_abnormal_chondrocyte_physiolo2.07003814
21MP0002733_abnormal_thermal_nociception2.05121673
22MP0002067_abnormal_sensory_capabilities2.03217881
23MP0001970_abnormal_pain_threshold1.99398475
24MP0008569_lethality_at_weaning1.98925881
25MP0003329_amyloid_beta_deposits1.88623363
26MP0002557_abnormal_social/conspecific_i1.85143090
27MP0005386_behavior/neurological_phenoty1.80980072
28MP0004924_abnormal_behavior1.80980072
29MP0002184_abnormal_innervation1.80443576
30MP0003879_abnormal_hair_cell1.77734973
31MP0005646_abnormal_pituitary_gland1.76847321
32MP0004811_abnormal_neuron_physiology1.75761907
33MP0004858_abnormal_nervous_system1.70099615
34MP0002909_abnormal_adrenal_gland1.69376848
35MP0000778_abnormal_nervous_system1.68618451
36MP0001984_abnormal_olfaction1.61575928
37MP0006276_abnormal_autonomic_nervous1.59580847
38MP0000955_abnormal_spinal_cord1.46729172
39MP0003787_abnormal_imprinting1.45993624
40MP0002066_abnormal_motor_capabilities/c1.43929749
41MP0004885_abnormal_endolymph1.41613954
42MP0003633_abnormal_nervous_system1.39819179
43MP0002882_abnormal_neuron_morphology1.37627085
44MP0005645_abnormal_hypothalamus_physiol1.32210691
45MP0001905_abnormal_dopamine_level1.28851397
46MP0001529_abnormal_vocalization1.21493616
47MP0004142_abnormal_muscle_tone1.20484057
48MP0003631_nervous_system_phenotype1.19996418
49MP0008872_abnormal_physiological_respon1.15873223
50MP0001502_abnormal_circadian_rhythm1.11491304
51MP0000569_abnormal_digit_pigmentation1.08125923
52MP0002152_abnormal_brain_morphology1.06345169
53MP0001188_hyperpigmentation1.04801690
54MP0003122_maternal_imprinting1.02546042
55MP0008874_decreased_physiological_sensi1.02354316
56MP0004147_increased_porphyrin_level1.01404260
57MP0005394_taste/olfaction_phenotype1.00785304
58MP0005499_abnormal_olfactory_system1.00785304
59MP0001177_atelectasis0.99835848
60MP0003123_paternal_imprinting0.99310059
61MP0002229_neurodegeneration0.93177776
62MP0004145_abnormal_muscle_electrophysio0.91568076
63MP0005535_abnormal_body_temperature0.91504241
64MP0002069_abnormal_eating/drinking_beha0.91309066
65MP0008877_abnormal_DNA_methylation0.90667093
66MP0000751_myopathy0.89904376
67MP0005623_abnormal_meninges_morphology0.89616192
68MP0003690_abnormal_glial_cell0.88512036
69MP0004085_abnormal_heartbeat0.86272808
70MP0000604_amyloidosis0.85667812
71MP0004742_abnormal_vestibular_system0.85642598
72MP0003632_abnormal_nervous_system0.85272254
73MP0001963_abnormal_hearing_physiology0.84152908
74MP0003075_altered_response_to0.81157774
75MP0004484_altered_response_of0.80925118
76MP0000013_abnormal_adipose_tissue0.80796532
77MP0002837_dystrophic_cardiac_calcinosis0.79443343
78MP0001348_abnormal_lacrimal_gland0.79041023
79MP0005551_abnormal_eye_electrophysiolog0.76879754
80MP0004215_abnormal_myocardial_fiber0.75334226
81MP0010386_abnormal_urinary_bladder0.71361422
82MP0003634_abnormal_glial_cell0.71072518
83MP0004043_abnormal_pH_regulation0.68965228
84MP0002638_abnormal_pupillary_reflex0.68251945
85MP0000631_abnormal_neuroendocrine_gland0.67720254
86MP0002876_abnormal_thyroid_physiology0.67701562
87MP0002752_abnormal_somatic_nervous0.67118510
88MP0000920_abnormal_myelination0.64940447
89MP0003283_abnormal_digestive_organ0.64389833
90MP0004233_abnormal_muscle_weight0.62514499
91MP0002090_abnormal_vision0.62496543
92MP0001485_abnormal_pinna_reflex0.62430949
93MP0001664_abnormal_digestion0.60360451
94MP0003137_abnormal_impulse_conducting0.60192204
95MP0003646_muscle_fatigue0.58893570
96MP0004510_myositis0.58871854
97MP0005167_abnormal_blood-brain_barrier0.58720051
98MP0008961_abnormal_basal_metabolism0.56916207
99MP0005409_darkened_coat_color0.56533213
100MP0003121_genomic_imprinting0.54950823
101MP0001943_abnormal_respiration0.53807734
102MP0010769_abnormal_survival0.51688515
103MP0001346_abnormal_lacrimal_gland0.51242714
104MP0001299_abnormal_eye_distance/0.50152672
105MP0002082_postnatal_lethality0.50141040
106MP0010770_preweaning_lethality0.50141040
107MP0003861_abnormal_nervous_system0.49264117
108MP0003956_abnormal_body_size0.48597210
109MP0003045_fibrosis0.48331865
110MP0010768_mortality/aging0.48202664
111MP0004130_abnormal_muscle_cell0.46932751
112MP0000579_abnormal_nail_morphology0.44396850
113MP0005620_abnormal_muscle_contractility0.42939180
114MP0001986_abnormal_taste_sensitivity0.41096779

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.43953617
2Myokymia (HP:0002411)7.00599095
3Focal seizures (HP:0007359)6.09611756
4Visual hallucinations (HP:0002367)5.21399299
5Epileptic encephalopathy (HP:0200134)5.20978334
6Atonic seizures (HP:0010819)5.01726813
7Febrile seizures (HP:0002373)4.84411336
8Progressive cerebellar ataxia (HP:0002073)4.65125590
9Absence seizures (HP:0002121)4.43671247
10Action tremor (HP:0002345)4.11198250
11Generalized tonic-clonic seizures (HP:0002069)4.06231728
12Dialeptic seizures (HP:0011146)4.05091304
13Hyperventilation (HP:0002883)4.02730449
14Broad-based gait (HP:0002136)3.99968904
15Gaze-evoked nystagmus (HP:0000640)3.83180202
16Poor eye contact (HP:0000817)3.59230833
17Impaired vibration sensation in the lower limbs (HP:0002166)3.54609735
18Dysdiadochokinesis (HP:0002075)3.40601700
19Abnormal social behavior (HP:0012433)3.31565786
20Impaired social interactions (HP:0000735)3.31565786
21Supranuclear gaze palsy (HP:0000605)3.30337595
22Truncal ataxia (HP:0002078)3.24133768
23Dysmetria (HP:0001310)3.19531336
24Tetraplegia (HP:0002445)3.16681823
25Ankle clonus (HP:0011448)3.13851070
26Depression (HP:0000716)3.12499024
27Urinary bladder sphincter dysfunction (HP:0002839)3.11038490
28Scanning speech (HP:0002168)3.06977548
29Abnormal eating behavior (HP:0100738)3.01621011
30Impaired smooth pursuit (HP:0007772)3.01611563
31Mutism (HP:0002300)2.97945972
32Postural instability (HP:0002172)2.96982420
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.96067722
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96067722
35Anxiety (HP:0000739)2.95851335
36Genetic anticipation (HP:0003743)2.92809660
37Papilledema (HP:0001085)2.89651475
38Dysmetric saccades (HP:0000641)2.87856583
39Drooling (HP:0002307)2.87029302
40Excessive salivation (HP:0003781)2.87029302
41Amblyopia (HP:0000646)2.84905543
42Abnormality of the lower motor neuron (HP:0002366)2.82395983
43Progressive inability to walk (HP:0002505)2.77650870
44Diplopia (HP:0000651)2.75731958
45Abnormality of binocular vision (HP:0011514)2.75731958
46Epileptiform EEG discharges (HP:0011182)2.69838780
47Fetal akinesia sequence (HP:0001989)2.68931838
48Urinary urgency (HP:0000012)2.66714504
49Abnormality of ocular smooth pursuit (HP:0000617)2.58455528
50Torticollis (HP:0000473)2.55842624
51Absent speech (HP:0001344)2.53380132
52Intention tremor (HP:0002080)2.53201446
53Cerebral hypomyelination (HP:0006808)2.52092899
54EEG with generalized epileptiform discharges (HP:0011198)2.52005305
55Stereotypic behavior (HP:0000733)2.50889019
56Status epilepticus (HP:0002133)2.49395562
57Hemiparesis (HP:0001269)2.48853100
58Impaired vibratory sensation (HP:0002495)2.46654578
59Bradykinesia (HP:0002067)2.46433023
60Spastic gait (HP:0002064)2.44193948
61Focal dystonia (HP:0004373)2.43999603
62Hypsarrhythmia (HP:0002521)2.40531230
63Ventricular fibrillation (HP:0001663)2.40386051
64Inability to walk (HP:0002540)2.38359873
65Termporal pattern (HP:0011008)2.37392814
66Insidious onset (HP:0003587)2.37392814
67Abnormality of the corticospinal tract (HP:0002492)2.36444683
68Horizontal nystagmus (HP:0000666)2.34680471
69Hemiplegia (HP:0002301)2.33966266
70Delusions (HP:0000746)2.33538551
71Pheochromocytoma (HP:0002666)2.31798387
72Cerebral inclusion bodies (HP:0100314)2.28750228
73Neurofibrillary tangles (HP:0002185)2.25721444
74Annular pancreas (HP:0001734)2.25603460
75Polyphagia (HP:0002591)2.19438550
76Generalized myoclonic seizures (HP:0002123)2.16709964
77Peripheral hypomyelination (HP:0007182)2.16247788
78Craniofacial dystonia (HP:0012179)2.10816653
79Morphological abnormality of the pyramidal tract (HP:0002062)2.09372216
80Blue irides (HP:0000635)2.08641666
81Gait ataxia (HP:0002066)2.07567979
82Limb dystonia (HP:0002451)2.06040595
83Lower limb muscle weakness (HP:0007340)2.03162538
84Protruding tongue (HP:0010808)2.02993016
85Amyotrophic lateral sclerosis (HP:0007354)2.02749155
86Obstructive sleep apnea (HP:0002870)2.01716698
87Increased circulating renin level (HP:0000848)2.01276319
88Spastic tetraparesis (HP:0001285)2.00279915
89Incomplete penetrance (HP:0003829)1.99960729
90Syncope (HP:0001279)1.98820089
91Resting tremor (HP:0002322)1.98497201
92Abnormality of saccadic eye movements (HP:0000570)1.98444204
93Megalencephaly (HP:0001355)1.97845613
94Apathy (HP:0000741)1.97306550
95Neuroendocrine neoplasm (HP:0100634)1.96495780
96Abnormality of salivation (HP:0100755)1.93630265
97Agitation (HP:0000713)1.91385804
98Prolonged QT interval (HP:0001657)1.90833738
99Inappropriate behavior (HP:0000719)1.90608102
100Lower limb amyotrophy (HP:0007210)1.90403194
101Spastic tetraplegia (HP:0002510)1.90369765
102Neuronal loss in central nervous system (HP:0002529)1.89273435
103Pointed chin (HP:0000307)1.84546374
104Rapidly progressive (HP:0003678)1.84136137
105Muscular hypotonia of the trunk (HP:0008936)1.83900731
106Akinesia (HP:0002304)1.83290960
107Postural tremor (HP:0002174)1.82244925
108CNS hypomyelination (HP:0003429)1.82215789
109Sleep apnea (HP:0010535)1.78267837
110Generalized hypopigmentation of hair (HP:0011358)1.77543308
111Lower limb asymmetry (HP:0100559)1.77035919
112Limb ataxia (HP:0002070)1.76134169
113Psychosis (HP:0000709)1.73656589
114Clonus (HP:0002169)1.73622203
115Rigidity (HP:0002063)1.73272893
116Aqueductal stenosis (HP:0002410)1.71728725
117Specific learning disability (HP:0001328)1.70711000
118Abnormal EKG (HP:0003115)1.70452047
119Bundle branch block (HP:0011710)1.68395475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.52919793
2EPHA44.27455152
3MAP3K93.78744276
4MAP3K43.21321785
5MARK13.07259332
6MAP2K72.74812722
7MINK12.66769223
8DAPK22.52037125
9CASK2.39800813
10MAP3K122.21455466
11RIPK42.15256855
12NTRK22.11981096
13PAK62.04922801
14MAP2K42.03826334
15KSR21.97519549
16CAMKK11.96462308
17CDK191.76979302
18DAPK11.75198206
19NTRK11.71753020
20PRKD31.65227788
21CAMKK21.56520926
22CDK51.53367330
23FRK1.52863962
24KSR11.51876731
25TNIK1.43717940
26PRPF4B1.43215373
27PLK21.41881896
28PNCK1.39550980
29STK381.32766066
30PRKCG1.28788640
31GRK51.28251598
32ARAF1.26316000
33MAPK131.26045973
34MAP3K21.16563614
35FES1.15303431
36SIK21.11617338
37LATS21.09501957
38CAMK2A1.07574453
39CAMK11.04742517
40TAOK11.01432413
41MAP3K131.00138003
42BMPR20.98424836
43OXSR10.93782421
44PHKG20.91376365
45PHKG10.91376365
46SGK2230.88894678
47SGK4940.88894678
48UHMK10.88281620
49SGK20.88239588
50CDK180.87054838
51RAF10.87002608
52CAMK2B0.86155160
53STK110.85852362
54MAP3K110.84897875
55CDK150.84687117
56TYRO30.84079350
57YES10.81722246
58CDK140.80377047
59LMTK20.80103159
60RET0.77716724
61PRKCH0.76613770
62PTK2B0.74343110
63PINK10.74011387
64SGK30.73380839
65SGK10.72801993
66CDK11A0.72567451
67PDK10.68339054
68ROCK20.67785069
69PAK30.67570202
70CCNB10.66256947
71DAPK30.66190559
72MARK20.64838886
73CSNK1G20.64221152
74DYRK1A0.62832653
75PDPK10.60851839
76ALK0.60576915
77FGFR20.58679275
78CSNK1G30.57768354
79TNK20.56892147
80DYRK20.55860527
81PRKCE0.55640161
82AKT30.55376792
83CSNK1A1L0.55238383
84ROCK10.53810862
85PKN10.52524160
86CAMK40.52166009
87MAP3K10.51898903
88CAMK1G0.50814779
89WNK10.48752903
90CAMK2G0.48179960
91RPS6KA30.47405660
92CAMK2D0.45870221
93PRKCZ0.45221873
94FYN0.44713887
95PRKG20.43961265
96MAP3K60.43352088
97CSNK1G10.43291330
98MAP2K10.43262322
99RIPK10.42414531
100NEK60.40459628
101MAPK100.40270358
102CSNK1D0.40218462
103WNK30.40193905
104PRKCA0.40085934
105PRKG10.40031753
106MAP3K70.40029868
107SCYL20.39532056
108PRKCB0.38414752
109FER0.38251804
110CDC42BPA0.36341162
111MAPK120.35618762
112MUSK0.35120428
113FGR0.33680907
114NME10.33490441
115LIMK10.32961614
116NEK10.32594262
117DMPK0.32365977
118BRAF0.32272676
119PRKACA0.31741140
120SIK30.31071108
121CSNK1A10.25903829
122BRSK10.25753227

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87542652
2Synaptic vesicle cycle_Homo sapiens_hsa047213.41280688
3Long-term potentiation_Homo sapiens_hsa047202.76746050
4Olfactory transduction_Homo sapiens_hsa047402.76614510
5Circadian entrainment_Homo sapiens_hsa047132.75300004
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75013342
7GABAergic synapse_Homo sapiens_hsa047272.73909303
8Glutamatergic synapse_Homo sapiens_hsa047242.63933382
9Morphine addiction_Homo sapiens_hsa050322.56743554
10Amphetamine addiction_Homo sapiens_hsa050312.53213456
11Salivary secretion_Homo sapiens_hsa049702.27380927
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17582052
13Dopaminergic synapse_Homo sapiens_hsa047282.15299701
14Gastric acid secretion_Homo sapiens_hsa049711.96455082
15Insulin secretion_Homo sapiens_hsa049111.93336201
16Taste transduction_Homo sapiens_hsa047421.91804880
17Cholinergic synapse_Homo sapiens_hsa047251.88594102
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85314626
19Long-term depression_Homo sapiens_hsa047301.81241912
20Serotonergic synapse_Homo sapiens_hsa047261.72373614
21Renin secretion_Homo sapiens_hsa049241.71708512
22Collecting duct acid secretion_Homo sapiens_hsa049661.71269207
23Oxytocin signaling pathway_Homo sapiens_hsa049211.65933700
24Calcium signaling pathway_Homo sapiens_hsa040201.63236615
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62517226
26Cocaine addiction_Homo sapiens_hsa050301.58155649
27GnRH signaling pathway_Homo sapiens_hsa049121.40854015
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40468215
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36875484
30Gap junction_Homo sapiens_hsa045401.33317380
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33111967
32cAMP signaling pathway_Homo sapiens_hsa040241.30315780
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21165822
34Type II diabetes mellitus_Homo sapiens_hsa049301.16760268
35Estrogen signaling pathway_Homo sapiens_hsa049151.14570386
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11694519
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09371639
38Glioma_Homo sapiens_hsa052141.08804722
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06167272
40Vitamin B6 metabolism_Homo sapiens_hsa007501.05114374
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04120932
42Axon guidance_Homo sapiens_hsa043601.03481769
43Vibrio cholerae infection_Homo sapiens_hsa051101.02156689
44ErbB signaling pathway_Homo sapiens_hsa040121.00529227
45Melanogenesis_Homo sapiens_hsa049160.99803446
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91942550
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.90703678
48Cardiac muscle contraction_Homo sapiens_hsa042600.86408010
49Pancreatic secretion_Homo sapiens_hsa049720.85200257
50Oocyte meiosis_Homo sapiens_hsa041140.82539962
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81256152
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80367147
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.79651152
54Thyroid hormone synthesis_Homo sapiens_hsa049180.78425112
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77333010
56Dorso-ventral axis formation_Homo sapiens_hsa043200.76751950
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76029095
58Nitrogen metabolism_Homo sapiens_hsa009100.71118438
59Choline metabolism in cancer_Homo sapiens_hsa052310.70844686
60MAPK signaling pathway_Homo sapiens_hsa040100.68115131
61Dilated cardiomyopathy_Homo sapiens_hsa054140.67984966
62Phototransduction_Homo sapiens_hsa047440.65397369
63Fatty acid biosynthesis_Homo sapiens_hsa000610.64361888
64Type I diabetes mellitus_Homo sapiens_hsa049400.61002534
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55663134
66VEGF signaling pathway_Homo sapiens_hsa043700.55219928
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55147722
68Ras signaling pathway_Homo sapiens_hsa040140.55132866
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.54547816
70Rap1 signaling pathway_Homo sapiens_hsa040150.54346996
71Glucagon signaling pathway_Homo sapiens_hsa049220.53756425
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53007299
73Inositol phosphate metabolism_Homo sapiens_hsa005620.52970659
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49680952
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49366095
76Bile secretion_Homo sapiens_hsa049760.49159734
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48341449
78mTOR signaling pathway_Homo sapiens_hsa041500.47749008
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46959923
80African trypanosomiasis_Homo sapiens_hsa051430.46191230
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45449991
82Alcoholism_Homo sapiens_hsa050340.44736639
83Circadian rhythm_Homo sapiens_hsa047100.44686567
84Endocytosis_Homo sapiens_hsa041440.40413455
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40378293
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39316794
87Non-small cell lung cancer_Homo sapiens_hsa052230.38599068
88Endometrial cancer_Homo sapiens_hsa052130.37863037
89Prion diseases_Homo sapiens_hsa050200.37613833
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37028018
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36788236
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36727966
93Ovarian steroidogenesis_Homo sapiens_hsa049130.36155870
94Wnt signaling pathway_Homo sapiens_hsa043100.35407133
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35275910
96Insulin signaling pathway_Homo sapiens_hsa049100.33189293
97Alzheimers disease_Homo sapiens_hsa050100.31497598
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31076408
99Renal cell carcinoma_Homo sapiens_hsa052110.30535747
100beta-Alanine metabolism_Homo sapiens_hsa004100.29562738
101Chemokine signaling pathway_Homo sapiens_hsa040620.29351300
102Tight junction_Homo sapiens_hsa045300.28223524
103Rheumatoid arthritis_Homo sapiens_hsa053230.28039471
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27893667
105Butanoate metabolism_Homo sapiens_hsa006500.23539269
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22483346
107Platelet activation_Homo sapiens_hsa046110.21515919
108AMPK signaling pathway_Homo sapiens_hsa041520.19234365
109Histidine metabolism_Homo sapiens_hsa003400.16820013
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16775583
111Mineral absorption_Homo sapiens_hsa049780.16284080
112Hippo signaling pathway_Homo sapiens_hsa043900.13395887

Most similar genes based on co-expression Upload to Enrichr

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