FRRS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.03619903
2drug catabolic process (GO:0042737)5.59889460
3regulation of protein activation cascade (GO:2000257)4.96653607
4regulation of fibrinolysis (GO:0051917)4.96066010
5negative regulation of fibrinolysis (GO:0051918)4.84521273
6cellular glucuronidation (GO:0052695)4.75655248
7indole-containing compound catabolic process (GO:0042436)4.73825273
8indolalkylamine catabolic process (GO:0046218)4.73825273
9tryptophan catabolic process (GO:0006569)4.73825273
10regulation of complement activation (GO:0030449)4.66351229
11glucuronate metabolic process (GO:0019585)4.60333581
12uronic acid metabolic process (GO:0006063)4.60333581
13epoxygenase P450 pathway (GO:0019373)4.58796812
14tryptophan metabolic process (GO:0006568)4.51445159
15glyoxylate metabolic process (GO:0046487)4.46614608
16aromatic amino acid family catabolic process (GO:0009074)4.45948124
17ribosomal small subunit assembly (GO:0000028)4.29299494
18S-adenosylmethionine metabolic process (GO:0046500)4.28522641
19omega-hydroxylase P450 pathway (GO:0097267)4.24226486
20bile acid biosynthetic process (GO:0006699)4.22908693
21negative regulation of protein activation cascade (GO:2000258)4.17243089
22L-phenylalanine catabolic process (GO:0006559)4.14586331
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.14586331
24complement activation, alternative pathway (GO:0006957)4.14309287
25bile acid metabolic process (GO:0008206)4.13848137
26oxidative demethylation (GO:0070989)4.09969346
27protein carboxylation (GO:0018214)3.96690318
28peptidyl-glutamic acid carboxylation (GO:0017187)3.96690318
29iron ion import (GO:0097286)3.95607746
30high-density lipoprotein particle remodeling (GO:0034375)3.87134417
31drug metabolic process (GO:0017144)3.86004390
32aminoglycoside antibiotic metabolic process (GO:0030647)3.84045207
33cysteine metabolic process (GO:0006534)3.81326460
34imidazole-containing compound metabolic process (GO:0052803)3.81199355
35very-low-density lipoprotein particle assembly (GO:0034379)3.78491198
36fibrinolysis (GO:0042730)3.77155200
37glycine metabolic process (GO:0006544)3.72888179
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69657733
39L-phenylalanine metabolic process (GO:0006558)3.69657733
40indolalkylamine metabolic process (GO:0006586)3.66202345
41phospholipid efflux (GO:0033700)3.66187932
42negative regulation of cholesterol transport (GO:0032375)3.65846032
43negative regulation of sterol transport (GO:0032372)3.65846032
44intestinal cholesterol absorption (GO:0030299)3.65434370
45plasma lipoprotein particle remodeling (GO:0034369)3.62625915
46protein-lipid complex remodeling (GO:0034368)3.62625915
47macromolecular complex remodeling (GO:0034367)3.62625915
48telomere maintenance via semi-conservative replication (GO:0032201)3.60244087
49kynurenine metabolic process (GO:0070189)3.60088620
50positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.55972002
51low-density lipoprotein particle remodeling (GO:0034374)3.54835497
52DNA strand elongation involved in DNA replication (GO:0006271)3.54559853
53urea metabolic process (GO:0019627)3.49397169
54cholesterol efflux (GO:0033344)3.48557950
55DNA strand elongation (GO:0022616)3.48292273
56triglyceride homeostasis (GO:0070328)3.47764939
57acylglycerol homeostasis (GO:0055090)3.47764939
58reverse cholesterol transport (GO:0043691)3.47743460
59tetrahydrofolate metabolic process (GO:0046653)3.45772962
60methionine biosynthetic process (GO:0009086)3.44181732
61bile acid and bile salt transport (GO:0015721)3.43432904
62maturation of SSU-rRNA (GO:0030490)3.42142508
63flavonoid metabolic process (GO:0009812)3.41663755
64negative regulation of complement activation (GO:0045916)3.41635155
65phospholipid homeostasis (GO:0055091)3.37357504
66telomere maintenance via recombination (GO:0000722)3.36983921
67heme transport (GO:0015886)3.35813892
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35070630
69retinal metabolic process (GO:0042574)3.35062066
70IMP biosynthetic process (GO:0006188)3.33990513
71L-methionine biosynthetic process (GO:0071265)3.29210806
72amino acid salvage (GO:0043102)3.29210806
73L-methionine salvage (GO:0071267)3.29210806
74DNA deamination (GO:0045006)3.28762445
75blood coagulation, intrinsic pathway (GO:0007597)3.28346732
76serine family amino acid metabolic process (GO:0009069)3.25371575
77DNA replication initiation (GO:0006270)3.24509949
78aromatic amino acid family metabolic process (GO:0009072)3.22959199
79plasma lipoprotein particle assembly (GO:0034377)3.22028562
80DNA replication checkpoint (GO:0000076)3.21600021
81amino-acid betaine metabolic process (GO:0006577)3.20049075
82serine family amino acid catabolic process (GO:0009071)3.14563174
83purine nucleobase biosynthetic process (GO:0009113)3.13162155
84nitrogen cycle metabolic process (GO:0071941)3.13086042
85arginine metabolic process (GO:0006525)3.11841994
86sulfur amino acid biosynthetic process (GO:0000097)3.11477204
87mitotic recombination (GO:0006312)3.10497209
88benzene-containing compound metabolic process (GO:0042537)3.09917579
89drug transmembrane transport (GO:0006855)3.07475008
90plasma lipoprotein particle clearance (GO:0034381)3.07418032
91plasma lipoprotein particle organization (GO:0071827)3.07348683
92negative regulation of lipase activity (GO:0060192)3.06970493
93alpha-amino acid catabolic process (GO:1901606)3.05629549
94IMP metabolic process (GO:0046040)3.05241595
95nucleobase biosynthetic process (GO:0046112)3.04845525
96CENP-A containing nucleosome assembly (GO:0034080)3.01911797
97aspartate family amino acid biosynthetic process (GO:0009067)3.01242911
98regulation of cholesterol esterification (GO:0010872)2.99578211
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97220727
100protein localization to kinetochore (GO:0034501)2.96957798
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95857631
102ribosomal large subunit biogenesis (GO:0042273)2.95485249
103homocysteine metabolic process (GO:0050667)2.95250657
104kinetochore organization (GO:0051383)2.92790087
105xenobiotic catabolic process (GO:0042178)2.92160303
106chromatin remodeling at centromere (GO:0031055)2.91679959
107cellular ketone body metabolic process (GO:0046950)2.91672520
108regulation of triglyceride catabolic process (GO:0010896)2.90570402
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90469023
110urea cycle (GO:0000050)2.89085401
111biotin metabolic process (GO:0006768)2.88910835
112telomere maintenance via telomere lengthening (GO:0010833)2.88712024
113phenylpropanoid metabolic process (GO:0009698)2.87630389
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83875064
115dicarboxylic acid biosynthetic process (GO:0043650)2.83474559
116mitotic metaphase plate congression (GO:0007080)2.83199223
117viral transcription (GO:0019083)2.82324912
118lipoprotein metabolic process (GO:0042157)2.81220690
119quinone metabolic process (GO:1901661)2.80771849
120ribosomal small subunit biogenesis (GO:0042274)2.80216023
121ethanol oxidation (GO:0006069)2.79892883
122ribonucleoprotein complex biogenesis (GO:0022613)2.78707665
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.77901248
124kinetochore assembly (GO:0051382)2.77724334
125translational termination (GO:0006415)2.77000506
126ribosome biogenesis (GO:0042254)2.74882492
127protein localization to chromosome, centromeric region (GO:0071459)2.65969145
128ribosome assembly (GO:0042255)2.64848373
129formation of translation preinitiation complex (GO:0001731)2.62698624
130definitive hemopoiesis (GO:0060216)2.62068086
131immunoglobulin mediated immune response (GO:0016064)2.61392188
132proteasome assembly (GO:0043248)2.57091073
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.56935803
134B cell mediated immunity (GO:0019724)2.56535275
135DNA replication-independent nucleosome assembly (GO:0006336)2.55131220
136DNA replication-independent nucleosome organization (GO:0034724)2.55131220
137replication fork processing (GO:0031297)2.54988932
138neutrophil activation involved in immune response (GO:0002283)2.54836150
139mitotic nuclear envelope disassembly (GO:0007077)2.53066695
140telomere maintenance (GO:0000723)2.52249506
141positive regulation of B cell differentiation (GO:0045579)2.52152105
142telomere organization (GO:0032200)2.50569890
143DNA unwinding involved in DNA replication (GO:0006268)2.50292473
144regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49629870
145nuclear pore complex assembly (GO:0051292)2.48431657
146rRNA processing (GO:0006364)2.48090141
147folic acid-containing compound biosynthetic process (GO:0009396)2.47392072
148pseudouridine synthesis (GO:0001522)2.46344551
149regulation of spindle organization (GO:0090224)2.45224293
150negative regulation of DNA-dependent DNA replication (GO:2000104)2.44106533
151pinocytosis (GO:0006907)2.43225348
152metaphase plate congression (GO:0051310)2.42802293
153folic acid metabolic process (GO:0046655)2.42697133
154translational initiation (GO:0006413)2.41224829
155positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41047283
156nuclear pore organization (GO:0006999)2.40155127
157production of molecular mediator involved in inflammatory response (GO:0002532)2.39995341
158rRNA metabolic process (GO:0016072)2.39821035
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.39432483
160daunorubicin metabolic process (GO:0044597)2.38822123
161polyketide metabolic process (GO:0030638)2.38822123
162doxorubicin metabolic process (GO:0044598)2.38822123
163translational elongation (GO:0006414)2.38457715
164response to interferon-beta (GO:0035456)2.33921588
165deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.33048309
166pore complex assembly (GO:0046931)2.30179288
167cotranslational protein targeting to membrane (GO:0006613)2.29877389
168protein targeting to ER (GO:0045047)2.29071630
169response to peptidoglycan (GO:0032494)2.28967908
170protein K6-linked ubiquitination (GO:0085020)2.28331278
171positive regulation of interferon-alpha production (GO:0032727)2.28312111
172nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.27285099
173modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.26432928
174positive regulation by organism of defense response of other organism involved in symbiotic interact2.26432928
175modulation by symbiont of host immune response (GO:0052553)2.26432928
176positive regulation by symbiont of host defense response (GO:0052509)2.26432928
177modulation by symbiont of host defense response (GO:0052031)2.26432928
178modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26432928
179Arp2/3 complex-mediated actin nucleation (GO:0034314)2.26084518
180nucleotide-excision repair, DNA gap filling (GO:0006297)2.24413330
181meiotic chromosome segregation (GO:0045132)2.22854740
182tRNA methylation (GO:0030488)2.21551939
183nuclear envelope disassembly (GO:0051081)2.20884178
184membrane disassembly (GO:0030397)2.20884178
185RNA-dependent DNA replication (GO:0006278)2.19251653
1863-UTR-mediated mRNA stabilization (GO:0070935)2.18937565
187establishment of chromosome localization (GO:0051303)2.18813217
188response to interferon-alpha (GO:0035455)2.17626946
189protein localization to endoplasmic reticulum (GO:0070972)2.15805975
190establishment of protein localization to endoplasmic reticulum (GO:0072599)2.15312903
191histone exchange (GO:0043486)2.15010050
192positive regulation of gamma-delta T cell activation (GO:0046645)2.13758339
193regulation of interferon-alpha production (GO:0032647)2.13564265
194neutrophil mediated immunity (GO:0002446)2.11775991
195positive regulation of interferon-beta production (GO:0032728)2.11720940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.95185321
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.73969025
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.26818025
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.19320396
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10436844
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98872668
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79351357
8IGF1R_20145208_ChIP-Seq_DFB_Human2.63288423
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58528408
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.45602064
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38338100
12* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34344783
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.33061067
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24939950
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.24388244
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23404407
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.21132591
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.18758282
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15955328
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.12558048
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12482423
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09379735
23ZNF274_21170338_ChIP-Seq_K562_Hela2.07265546
24VDR_22108803_ChIP-Seq_LS180_Human2.06279189
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.05795936
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04938238
27PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01399217
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99073550
29* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95938412
30SCL_19346495_ChIP-Seq_HPC-7_Human1.95304690
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94720225
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.88916139
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.88070528
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82072756
35SPI1_23547873_ChIP-Seq_NB4_Human1.81271516
36VDR_23849224_ChIP-Seq_CD4+_Human1.81022310
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79743583
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78097217
39AR_21909140_ChIP-Seq_LNCAP_Human1.77494715
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76019364
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75098246
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74511113
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74104879
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73846627
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73678970
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72893940
47FOXP3_21729870_ChIP-Seq_TREG_Human1.66019350
48IRF1_19129219_ChIP-ChIP_H3396_Human1.65678765
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.65143562
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62597932
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61424630
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60634606
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.60469444
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59382356
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54835991
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53762931
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53554728
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51715461
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50824426
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49599774
61ER_23166858_ChIP-Seq_MCF-7_Human1.49072505
62XRN2_22483619_ChIP-Seq_HELA_Human1.47529763
63ELK1_19687146_ChIP-ChIP_HELA_Human1.47309429
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.46596910
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45644456
66DCP1A_22483619_ChIP-Seq_HELA_Human1.45398448
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44089431
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42896574
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.41405269
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40830589
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40036776
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39399642
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.38064443
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.36286968
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36176565
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.36076241
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35713629
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35296331
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33894188
80* GATA4_25053715_ChIP-Seq_YYC3_Human1.33392617
81VDR_21846776_ChIP-Seq_THP-1_Human1.33224865
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30988804
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30056922
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29675391
85MYC_22102868_ChIP-Seq_BL_Human1.29478026
86GABP_19822575_ChIP-Seq_HepG2_Human1.29225812
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29169117
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29066032
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28389369
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27518682
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27404475
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27082367
93TTF2_22483619_ChIP-Seq_HELA_Human1.25272671
94FUS_26573619_Chip-Seq_HEK293_Human1.24566156
95* CDX2_22108803_ChIP-Seq_LS180_Human1.24373567
96* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23940736
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23703445
98GBX2_23144817_ChIP-Seq_PC3_Human1.20857445
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20777292
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20755736
101TAF15_26573619_Chip-Seq_HEK293_Human1.20721470
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20158285
103STAT3_23295773_ChIP-Seq_U87_Human1.19520351
104* PHF8_20622853_ChIP-Seq_HELA_Human1.18107452
105* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18014304
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17889737
107* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17600222
108* GATA6_21074721_ChIP-Seq_CACO-2_Human1.16746102
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16489037
110TFEB_21752829_ChIP-Seq_HELA_Human1.16487771
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.16066765
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15964667
113* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14651229
114* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13848505
115CBP_20019798_ChIP-Seq_JUKART_Human1.13087795
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13087795
117* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12888972
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12773140
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12683481
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12555624
121* ETV1_20927104_ChIP-Seq_GIST48_Human1.12418089
122* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11509627
123TP53_16413492_ChIP-PET_HCT116_Human1.11137441
124* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10683590
125* HNFA_21074721_ChIP-Seq_CACO-2_Human1.10597429
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10331304
127* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10159498
128CIITA_25753668_ChIP-Seq_RAJI_Human1.09948780
129* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08629482
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08532803
131* RBPJ_21746931_ChIP-Seq_IB4_Human1.08283700
132AR_20517297_ChIP-Seq_VCAP_Human1.08138142
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07693723
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07511741
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06789289
136GATA1_22025678_ChIP-Seq_K562_Human1.06781317
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06603629
138MYB_26560356_Chip-Seq_TH1_Human1.06113017
139EWS_26573619_Chip-Seq_HEK293_Human1.06088152
140KDM5A_27292631_Chip-Seq_BREAST_Human1.06048071
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05806087
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.05727408
143* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05571501
144PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05129880
145PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04559735
146* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04189994
147SOX2_19829295_ChIP-Seq_ESCs_Human1.01544834
148NANOG_19829295_ChIP-Seq_ESCs_Human1.01544834
149FOXA1_25329375_ChIP-Seq_VCAP_Human1.01182504
150FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01182504
151MYB_26560356_Chip-Seq_TH2_Human1.01034947
152GATA6_25053715_ChIP-Seq_YYC3_Human1.00130075
153* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99320688
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98747377
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98177185
156GATA2_19941826_ChIP-Seq_K562_Human0.98075708
157* NFYA_21822215_ChIP-Seq_K562_Human0.97917597
158TCF4_22108803_ChIP-Seq_LS180_Human0.97775936
159* NFYB_21822215_ChIP-Seq_K562_Human0.97364500
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.97165799
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97014107
162* STAT3_18555785_Chip-Seq_ESCs_Mouse0.96196244
163BCAT_22108803_ChIP-Seq_LS180_Human0.95421620
164TCF4_23295773_ChIP-Seq_U87_Human0.95374780
165P300_18555785_Chip-Seq_ESCs_Mouse0.95156181
166ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94913616
167TP63_19390658_ChIP-ChIP_HaCaT_Human0.94591829
168* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94447858
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94412386
170MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94350407
171THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94178061
172SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94022735
173MAF_26560356_Chip-Seq_TH1_Human0.93893209
174ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93685742
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92319149
176VDR_24763502_ChIP-Seq_THP-1_Human0.91057502
177POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90266757
178TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90102526
179E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89702201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.45233860
2MP0008875_abnormal_xenobiotic_pharmacok4.33679269
3MP0005365_abnormal_bile_salt4.24020805
4MP0003252_abnormal_bile_duct3.69761323
5MP0003693_abnormal_embryo_hatching3.62737608
6MP0002396_abnormal_hematopoietic_system3.17032906
7MP0008057_abnormal_DNA_replication2.88892800
8MP0003111_abnormal_nucleus_morphology2.69213573
9MP0010329_abnormal_lipoprotein_level2.58037520
10MP0010094_abnormal_chromosome_stability2.55555737
11MP0001661_extended_life_span2.37903357
12MP0004957_abnormal_blastocyst_morpholog2.30291210
13MP0001835_abnormal_antigen_presentation2.26202683
14MP0003077_abnormal_cell_cycle2.25761422
15MP0000490_abnormal_crypts_of2.19065033
16MP0008058_abnormal_DNA_repair2.17288134
17MP0001545_abnormal_hematopoietic_system2.13920011
18MP0005397_hematopoietic_system_phenotyp2.13920011
19MP0001666_abnormal_nutrient_absorption2.11883382
20MP0003436_decreased_susceptibility_to2.10005031
21MP0005174_abnormal_tail_pigmentation1.96509997
22MP0005408_hypopigmentation1.94987442
23MP0005332_abnormal_amino_acid1.94668431
24MP0005464_abnormal_platelet_physiology1.92818323
25MP0003724_increased_susceptibility_to1.90932632
26MP0009785_altered_susceptibility_to1.87749839
27MP0008007_abnormal_cellular_replicative1.84040561
28MP0002419_abnormal_innate_immunity1.82888283
29MP0003868_abnormal_feces_composition1.81696104
30MP0005083_abnormal_biliary_tract1.78804058
31MP0000609_abnormal_liver_physiology1.78615072
32MP0005451_abnormal_body_composition1.74559960
33MP0005025_abnormal_response_to1.74152107
34MP0010307_abnormal_tumor_latency1.71581584
35MP0002148_abnormal_hypersensitivity_rea1.68989556
36MP0001853_heart_inflammation1.64993062
37MP0004808_abnormal_hematopoietic_stem1.64552658
38MP0005075_abnormal_melanosome_morpholog1.58733160
39MP0002876_abnormal_thyroid_physiology1.58046952
40MP0003172_abnormal_lysosome_physiology1.56483600
41MP0000383_abnormal_hair_follicle1.56009272
42MP0005058_abnormal_lysosome_morphology1.55723729
43MP0009333_abnormal_splenocyte_physiolog1.55580138
44MP0002452_abnormal_antigen_presenting1.54180387
45MP0001800_abnormal_humoral_immune1.54144813
46MP0005000_abnormal_immune_tolerance1.52587995
47MP0005671_abnormal_response_to1.50946280
48MP0010352_gastrointestinal_tract_polyps1.46682314
49MP0000689_abnormal_spleen_morphology1.46242383
50MP0003186_abnormal_redox_activity1.45597845
51MP0002398_abnormal_bone_marrow1.45551021
52MP0002723_abnormal_immune_serum1.44825704
53MP0000465_gastrointestinal_hemorrhage1.42928382
54MP0000858_altered_metastatic_potential1.38815180
55MP0009840_abnormal_foam_cell1.38797650
56MP0001819_abnormal_immune_cell1.38793497
57MP0009278_abnormal_bone_marrow1.38666830
58MP0002420_abnormal_adaptive_immunity1.38556205
59MP0002722_abnormal_immune_system1.37916618
60MP0010155_abnormal_intestine_physiology1.31632550
61MP0010678_abnormal_skin_adnexa1.31587166
62MP0003656_abnormal_erythrocyte_physiolo1.31580491
63MP0003786_premature_aging1.28582386
64MP0002118_abnormal_lipid_homeostasis1.28178886
65MP0005636_abnormal_mineral_homeostasis1.27322658
66MP0000716_abnormal_immune_system1.24494764
67MP0002429_abnormal_blood_cell1.23325221
68MP0006082_CNS_inflammation1.23077078
69MP0000685_abnormal_immune_system1.22996128
70MP0000569_abnormal_digit_pigmentation1.22925405
71MP0002006_tumorigenesis1.22173935
72MP0003890_abnormal_embryonic-extraembry1.22078880
73MP0003806_abnormal_nucleotide_metabolis1.21787638
74MP0003941_abnormal_skin_development1.21318482
75MP0002132_abnormal_respiratory_system1.20841080
76MP0003950_abnormal_plasma_membrane1.20276963
77MP0003763_abnormal_thymus_physiology1.20104892
78MP0002405_respiratory_system_inflammati1.18756255
79MP0001845_abnormal_inflammatory_respons1.18444813
80MP0002019_abnormal_tumor_incidence1.18397934
81MP0002166_altered_tumor_susceptibility1.16841558
82MP0000015_abnormal_ear_pigmentation1.16626997
83MP0003718_maternal_effect1.14781780
84MP0002098_abnormal_vibrissa_morphology1.14097954
85MP0008469_abnormal_protein_level1.12998012
86MP0000427_abnormal_hair_cycle1.12436452
87MP0006035_abnormal_mitochondrial_morpho1.12259213
88MP0005551_abnormal_eye_electrophysiolog1.10678019
89MP0000350_abnormal_cell_proliferation1.10364744
90MP0005387_immune_system_phenotype1.09543619
91MP0001790_abnormal_immune_system1.09543619
92MP0000313_abnormal_cell_death1.09355138
93MP0003566_abnormal_cell_adhesion1.08778632
94MP0008932_abnormal_embryonic_tissue1.08666911
95MP0001873_stomach_inflammation1.06585297
96MP0003191_abnormal_cellular_cholesterol1.05770364
97MP0008775_abnormal_heart_ventricle1.05314676
98MP0003567_abnormal_fetal_cardiomyocyte1.03379507
99MP0003448_altered_tumor_morphology1.02489075
100MP0003303_peritoneal_inflammation1.01833601
101MP0008995_early_reproductive_senescence1.00719624
102MP0005395_other_phenotype0.98576870
103MP0004272_abnormal_basement_membrane0.97753829
104MP0004947_skin_inflammation0.97076191
105MP0002234_abnormal_pharynx_morphology0.96946907
106MP0005645_abnormal_hypothalamus_physiol0.96191423
107MP0000703_abnormal_thymus_morphology0.95821516
108MP0000647_abnormal_sebaceous_gland0.94999846
109MP0001533_abnormal_skeleton_physiology0.94515679
110MP0002095_abnormal_skin_pigmentation0.94411860
111MP0001764_abnormal_homeostasis0.93378831
112MP0000372_irregular_coat_pigmentation0.92681620
113MP0004147_increased_porphyrin_level0.91900158
114MP0004264_abnormal_extraembryonic_tissu0.91620430
115MP0002139_abnormal_hepatobiliary_system0.90730553
116MP0000343_altered_response_to0.90327666
117MP0009763_increased_sensitivity_to0.89874865
118MP0000371_diluted_coat_color0.87727770
119MP0005023_abnormal_wound_healing0.87353800
120MP0004019_abnormal_vitamin_homeostasis0.87229663
121MP0009697_abnormal_copulation0.86902294
122MP0003828_pulmonary_edema0.86124098
123MP0005376_homeostasis/metabolism_phenot0.85615489
124MP0009643_abnormal_urine_homeostasis0.85196681
125MP0010234_abnormal_vibrissa_follicle0.83408252
126MP0002009_preneoplasia0.82789593
127MP0005360_urolithiasis0.82596643
128MP0001730_embryonic_growth_arrest0.82281650
129MP0005220_abnormal_exocrine_pancreas0.81542647
130MP0006054_spinal_hemorrhage0.80879144
131MP0000598_abnormal_liver_morphology0.80827163
132MP0009764_decreased_sensitivity_to0.80217497
133MP0003300_gastrointestinal_ulcer0.77807624
134MP0002282_abnormal_trachea_morphology0.75846823
135MP0005380_embryogenesis_phenotype0.75620111
136MP0001672_abnormal_embryogenesis/_devel0.75620111
137MP0002086_abnormal_extraembryonic_tissu0.75339580
138MP0005085_abnormal_gallbladder_physiolo0.75259824
139MP0004782_abnormal_surfactant_physiolog0.74677450
140MP0002138_abnormal_hepatobiliary_system0.72684906
141MP0005275_abnormal_skin_tensile0.72334671
142MP0005319_abnormal_enzyme/_coenzyme0.72105718
143MP0009115_abnormal_fat_cell0.71491393
144MP0001216_abnormal_epidermal_layer0.68729619
145MP0001915_intracranial_hemorrhage0.68599738
146MP0005647_abnormal_sex_gland0.67299276
147MP0006036_abnormal_mitochondrial_physio0.66480653
148MP0005410_abnormal_fertilization0.65198984
149MP0000467_abnormal_esophagus_morphology0.64590301
150MP0002254_reproductive_system_inflammat0.63863213
151MP0000358_abnormal_cell_content/0.63813292
152MP0005187_abnormal_penis_morphology0.62575854
153MP0004043_abnormal_pH_regulation0.59037761
154MP0009642_abnormal_blood_homeostasis0.58895896
155MP0008872_abnormal_physiological_respon0.58881027
156MP0005334_abnormal_fat_pad0.58867870
157MP0005584_abnormal_enzyme/coenzyme_acti0.58844945
158MP0003943_abnormal_hepatobiliary_system0.58539113
159MP0001929_abnormal_gametogenesis0.58363705
160MP0005501_abnormal_skin_physiology0.57931002
161MP0005164_abnormal_response_to0.55346930
162MP0005253_abnormal_eye_physiology0.55045489
163MP0003646_muscle_fatigue0.54211782
164MP0002090_abnormal_vision0.54058934
165MP0002796_impaired_skin_barrier0.52981928
166MP0005266_abnormal_metabolism0.51720681
167MP0005389_reproductive_system_phenotype0.51579265
168MP0002168_other_aberrant_phenotype0.50949789
169MP0002971_abnormal_brown_adipose0.50474862

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.44903690
2Prolonged partial thromboplastin time (HP:0003645)5.37900098
3Conjugated hyperbilirubinemia (HP:0002908)4.85932112
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.64363533
5Deep venous thrombosis (HP:0002625)4.42970919
6Complement deficiency (HP:0004431)3.98830964
7Recurrent abscess formation (HP:0002722)3.84969515
8Chromsome breakage (HP:0040012)3.84213853
9Abnormality of the common coagulation pathway (HP:0010990)3.74506386
10Poikilocytosis (HP:0004447)3.73311054
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70155638
12Intrahepatic cholestasis (HP:0001406)3.68098301
13Reticulocytopenia (HP:0001896)3.58016562
14Recurrent bacterial skin infections (HP:0005406)3.47605396
15Acanthocytosis (HP:0001927)3.43969790
16Spontaneous abortion (HP:0005268)3.42091601
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.41478450
18Epidermoid cyst (HP:0200040)3.33126833
19Hypolipoproteinemia (HP:0010981)3.27817958
20Abnormal number of erythroid precursors (HP:0012131)3.25261545
21Thrombocytosis (HP:0001894)3.21294477
22Reduced antithrombin III activity (HP:0001976)3.18600129
23Generalized aminoaciduria (HP:0002909)3.16647300
24Abnormality of cells of the erythroid lineage (HP:0012130)3.15147925
25Aplastic anemia (HP:0001915)3.11507209
26Xanthomatosis (HP:0000991)3.05994833
27Petechiae (HP:0000967)3.01020258
28Prolonged bleeding time (HP:0003010)2.98352124
29Vacuolated lymphocytes (HP:0001922)2.94689256
30Abnormality of chromosome stability (HP:0003220)2.89293409
31Abnormality of the preputium (HP:0100587)2.85581409
32Eczematoid dermatitis (HP:0000976)2.84539045
33Fair hair (HP:0002286)2.84013945
34Fat malabsorption (HP:0002630)2.78017311
35Myelodysplasia (HP:0002863)2.75939188
36Birth length less than 3rd percentile (HP:0003561)2.74922460
37Hyperglycinuria (HP:0003108)2.72368716
38Myositis (HP:0100614)2.72105555
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68528706
40Agnosia (HP:0010524)2.68234580
41Renal cortical cysts (HP:0000803)2.66344508
42Abnormality of methionine metabolism (HP:0010901)2.66160809
43Abnormality of complement system (HP:0005339)2.64801550
44Pustule (HP:0200039)2.64273206
45Abnormality of the prostate (HP:0008775)2.64096638
46Abnormality of the renal cortex (HP:0011035)2.63281501
47Hyperammonemia (HP:0001987)2.62175336
48Recurrent gram-negative bacterial infections (HP:0005420)2.58213145
49Type I transferrin isoform profile (HP:0003642)2.57716998
50Osteomalacia (HP:0002749)2.57199991
51Abnormality of pyrimidine metabolism (HP:0004353)2.55608198
52Hyperbilirubinemia (HP:0002904)2.54569481
53Clubbing of toes (HP:0100760)2.52888902
54Abnormality of macrophages (HP:0004311)2.52870403
55Prostate neoplasm (HP:0100787)2.52149441
56Periodontitis (HP:0000704)2.51854091
57Nausea (HP:0002018)2.51315227
58Bone marrow hypocellularity (HP:0005528)2.50940203
59Elevated erythrocyte sedimentation rate (HP:0003565)2.50333008
60Epistaxis (HP:0000421)2.49001584
61Pallor (HP:0000980)2.46817075
62Oral leukoplakia (HP:0002745)2.45667820
63IgM deficiency (HP:0002850)2.42676973
64Meckel diverticulum (HP:0002245)2.42520588
65Hyperglycinemia (HP:0002154)2.40646529
66Abnormality of the intrinsic pathway (HP:0010989)2.36812488
67Impaired platelet aggregation (HP:0003540)2.33900328
68Abnormal platelet function (HP:0011869)2.33900328
69Hypophosphatemic rickets (HP:0004912)2.31928167
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.31862331
71Reticulocytosis (HP:0001923)2.31842356
72Obstructive lung disease (HP:0006536)2.30543825
73Chronic obstructive pulmonary disease (HP:0006510)2.30543825
74Mediastinal lymphadenopathy (HP:0100721)2.30044277
75Abnormality of the ileum (HP:0001549)2.29992798
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.29441770
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.29371177
78Abnormal gallbladder physiology (HP:0012438)2.27201181
79Cholecystitis (HP:0001082)2.27201181
80Orchitis (HP:0100796)2.26943371
81Abnormality of transition element cation homeostasis (HP:0011030)2.24981176
82Rough bone trabeculation (HP:0100670)2.24403058
83Gingival bleeding (HP:0000225)2.24094118
84Hepatocellular carcinoma (HP:0001402)2.23040337
85Abnormality of glycine metabolism (HP:0010895)2.22723075
86Abnormality of serine family amino acid metabolism (HP:0010894)2.22723075
87Abnormality of nail color (HP:0100643)2.22259456
88Submucous cleft hard palate (HP:0000176)2.21247087
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20539889
90Abnormality of urine glucose concentration (HP:0011016)2.19801716
91Glycosuria (HP:0003076)2.19801716
92Onycholysis (HP:0001806)2.18310811
93Increased serum pyruvate (HP:0003542)2.16861468
94Proximal tubulopathy (HP:0000114)2.16818557
95Glomerulonephritis (HP:0000099)2.15776865
96Abnormality of alanine metabolism (HP:0010916)2.13156259
97Hyperalaninemia (HP:0003348)2.13156259
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13156259
99Right ventricular cardiomyopathy (HP:0011663)2.12034753
100Recurrent fungal infections (HP:0002841)2.11948886
101Steatorrhea (HP:0002570)2.11484459
102Arthropathy (HP:0003040)2.10779506
103Recurrent viral infections (HP:0004429)2.10340295
104Retrobulbar optic neuritis (HP:0100654)2.09619964
105Optic neuritis (HP:0100653)2.09619964
106Abnormal biliary tract physiology (HP:0012439)2.09501730
107Bile duct proliferation (HP:0001408)2.09501730
108Tubulointerstitial nephritis (HP:0001970)2.09065112
109Recurrent skin infections (HP:0001581)2.08386861
110Menorrhagia (HP:0000132)2.08046529
111Pancytopenia (HP:0001876)2.07551301
112Leukopenia (HP:0001882)2.07398745
113Macrocytic anemia (HP:0001972)2.06487553
114Azoospermia (HP:0000027)2.06439992
115Amaurosis fugax (HP:0100576)2.06243434
116Acute myeloid leukemia (HP:0004808)2.05891533
117Hypoglycemic coma (HP:0001325)2.05189218
118Abnormality of serum amino acid levels (HP:0003112)2.03280479
119Joint hemorrhage (HP:0005261)2.03038578
120Enlarged kidneys (HP:0000105)2.03001029
121Autoimmune thrombocytopenia (HP:0001973)2.00827916
122Impulsivity (HP:0100710)2.00624430
123Rickets (HP:0002748)2.00242463
124Pancreatic cysts (HP:0001737)2.00013678
125Abnormality of glycolysis (HP:0004366)1.99561643
126Gingivitis (HP:0000230)1.98224100
127Duplicated collecting system (HP:0000081)1.97781179
128Abnormal trabecular bone morphology (HP:0100671)1.97488287
129Plantar hyperkeratosis (HP:0007556)1.96822137
130Pancreatic islet-cell hyperplasia (HP:0004510)1.95674684
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.95392314
132Absent thumb (HP:0009777)1.94956318
133Abnormality of lateral ventricle (HP:0030047)1.94479954
134Cheilitis (HP:0100825)1.94076972
135Abnormality of T cell physiology (HP:0011840)1.93885078
136Increased serum ferritin (HP:0003281)1.91845028
137Encephalitis (HP:0002383)1.91309560
138Duodenal stenosis (HP:0100867)1.90653565
139Small intestinal stenosis (HP:0012848)1.90653565
140Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89131909
141Lymphoma (HP:0002665)1.88720549
142Metabolic acidosis (HP:0001942)1.88599943
143Ectropion (HP:0000656)1.88091583
144Anorexia (HP:0002039)1.87045315
145Abnormal platelet volume (HP:0011876)1.85325194
146Abnormality of DNA repair (HP:0003254)1.84407250
147Premature graying of hair (HP:0002216)1.84159426
148Granulocytopenia (HP:0001913)1.83890746
149Generalized hypopigmentation of hair (HP:0011358)1.83082447
150Hypoplastic labia majora (HP:0000059)1.82529668
151Basal ganglia calcification (HP:0002135)1.82055555
152Abnormality of reticulocytes (HP:0004312)1.82049824
153Hypochromic anemia (HP:0001931)1.81439243
154Abnormality of the anterior horn cell (HP:0006802)1.81268567
155Degeneration of anterior horn cells (HP:0002398)1.81268567
156Increased cerebral lipofuscin (HP:0011813)1.81113685
157Vascular calcification (HP:0004934)1.79054304
158Hypothermia (HP:0002045)1.78656760
159Hyperlipoproteinemia (HP:0010980)1.78165124
160Tubulointerstitial abnormality (HP:0001969)1.78136950
161Hypercholesterolemia (HP:0003124)1.77911048
162Nephritis (HP:0000123)1.77566815
163Abnormal hair laboratory examination (HP:0003328)1.76945741
164Palmoplantar hyperkeratosis (HP:0000972)1.76764059
165Abnormality of nucleobase metabolism (HP:0010932)1.76699446
166Systemic lupus erythematosus (HP:0002725)1.76664558
167Palmar hyperkeratosis (HP:0010765)1.76628386
168Entropion (HP:0000621)1.76424983
169Breast hypoplasia (HP:0003187)1.75803252
170Cholelithiasis (HP:0001081)1.75503154
171Hypoalphalipoproteinemia (HP:0003233)1.75467273
172Leukocytosis (HP:0001974)1.75411161
173Chronic hepatic failure (HP:0100626)1.75286551
174Abnormality of the renal collecting system (HP:0004742)1.74744166
175Microcytic anemia (HP:0001935)1.74278815
176Abnormal gallbladder morphology (HP:0012437)1.74179774
177Abnormality of iron homeostasis (HP:0011031)1.72517560
178Myocardial infarction (HP:0001658)1.72465573
17911 pairs of ribs (HP:0000878)1.72047935
180Ectopic kidney (HP:0000086)1.71551450
181Poikiloderma (HP:0001029)1.71066259
182Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71064548
183Abnormal protein N-linked glycosylation (HP:0012347)1.71064548
184Abnormal protein glycosylation (HP:0012346)1.71064548
185Abnormal glycosylation (HP:0012345)1.71064548
186Microretrognathia (HP:0000308)1.70446320
187Pulmonary fibrosis (HP:0002206)1.70283706
188Thrombophlebitis (HP:0004418)1.64540345
189Congenital stationary night blindness (HP:0007642)1.61131281
190Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60717792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.55546216
2WEE13.25804597
3NME22.88003472
4STK162.38179821
5BUB12.36665180
6EIF2AK12.25054064
7IRAK32.23058832
8EPHA22.11210209
9IRAK42.09713920
10PBK2.04638294
11MAP3K22.00920885
12PIM21.98064041
13CDC71.87891225
14AKT31.86332566
15BLK1.86175536
16MAP4K21.84925912
17SRPK11.84345883
18KIT1.84043518
19NEK21.79481245
20WNK41.74913827
21LATS11.74868361
22BRSK21.73359757
23MAP2K31.71684760
24MKNK11.70634845
25FER1.68926578
26MAP4K11.68538850
27PDK21.67988613
28TEC1.64919774
29MKNK21.59512480
30EIF2AK31.56726659
31PIM11.56269346
32CDK71.54236466
33MAP3K141.51485421
34ACVR1B1.49842972
35BMPR1B1.48722096
36EIF2AK21.47939039
37EEF2K1.47013679
38ADRBK21.46806141
39RPS6KA41.43474588
40MST1R1.43118873
41TTK1.42589297
42PLK41.42526073
43ZAK1.42084268
44BMPR21.41946883
45PINK11.38795428
46BTK1.37202534
47TXK1.34223064
48ATR1.33637304
49TAOK31.31515840
50RPS6KB21.30815055
51WNK31.30071356
52TGFBR21.28854299
53CDK41.28462059
54IKBKB1.28387477
55PLK11.27130917
56AURKB1.25283230
57CDK121.24272965
58TYK21.24174295
59STK101.23904882
60STK41.23354682
61NEK11.23220734
62JAK31.22909329
63ZAP701.21465614
64VRK11.19483013
65MAP3K41.18398796
66TSSK61.13140000
67GRK11.12194605
68NEK91.11613270
69PRKAA21.11499528
70TBK11.10343305
71TLK11.07934872
72STK38L1.05466731
73ERBB31.01032178
74DYRK30.98621273
75IKBKE0.95523816
76MATK0.93983431
77CDK60.93578535
78PAK40.91207897
79FLT30.91143911
80MAPK110.90903703
81CHEK20.86948486
82STK390.85505796
83CHUK0.83469127
84RIPK40.83153607
85IRAK10.82143996
86LYN0.79471397
87MAPK130.79076646
88MAP3K80.77155633
89PRKAA10.76481650
90CSF1R0.75849935
91PASK0.75242763
92BCKDK0.73764404
93CAMK1G0.73388478
94PIK3CG0.72711342
95YES10.71296033
96RPS6KB10.71001288
97RAF10.70728110
98CDK80.68610794
99CLK10.68544264
100SCYL20.68212931
101STK30.67255348
102SYK0.67001929
103TGFBR10.66853535
104ERBB40.65757231
105MET0.63008791
106MAP2K10.62568972
107MAPKAPK50.62449733
108FGFR30.62379396
109KDR0.61366161
110MAP3K60.60666305
111CHEK10.60366755
112LCK0.59836148
113TRPM70.59251260
114ATM0.58793133
115PLK30.58544436
116NUAK10.57348867
117JAK20.56973076
118CSNK2A10.56428137
119ABL20.56320716
120MAP3K110.55067492
121HCK0.54475416
122JAK10.52485411
123BRD40.51972885
124INSRR0.51933143
125MAP3K30.51668418
126CSK0.51076213
127PIK3CA0.51065417
128CSNK2A20.50213632
129AURKA0.49639180
130MAPKAPK30.49338549
131ICK0.48166183
132PRKACG0.47795063
133CAMK1D0.47665587
134BRSK10.47342193
135ERN10.47044289
136PRKCE0.46431471
137RPS6KA60.46043637
138CCNB10.45582448
139CDK20.44107772
140MST40.43725723
141RPS6KA50.43725362
142ABL10.42929454
143RPS6KC10.40894393
144WNK10.40743432
145PLK20.40718632
146BCR0.39949511
147ERBB20.38362853
148CAMKK20.37760556
149KSR20.37682521
150CSNK1E0.35756228
151IGF1R0.35437381
152OXSR10.35076258

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89281249
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.24606030
3Mismatch repair_Homo sapiens_hsa034302.97345393
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91662202
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.71724491
6Ribosome_Homo sapiens_hsa030102.70657427
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.69652580
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65603376
9Retinol metabolism_Homo sapiens_hsa008302.59580737
10Homologous recombination_Homo sapiens_hsa034402.57250458
11One carbon pool by folate_Homo sapiens_hsa006702.39144241
12Base excision repair_Homo sapiens_hsa034102.34931467
13Butanoate metabolism_Homo sapiens_hsa006502.28377132
14RNA polymerase_Homo sapiens_hsa030202.12416523
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07667392
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02754930
17Non-homologous end-joining_Homo sapiens_hsa034502.00062967
18Tryptophan metabolism_Homo sapiens_hsa003801.97128846
19Pyrimidine metabolism_Homo sapiens_hsa002401.93490486
20Fanconi anemia pathway_Homo sapiens_hsa034601.92351531
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91025037
22Fatty acid degradation_Homo sapiens_hsa000711.90117474
23Nucleotide excision repair_Homo sapiens_hsa034201.87124597
24Proteasome_Homo sapiens_hsa030501.85721583
25Spliceosome_Homo sapiens_hsa030401.83489559
26Linoleic acid metabolism_Homo sapiens_hsa005911.79809938
27Arginine biosynthesis_Homo sapiens_hsa002201.77569248
28RNA transport_Homo sapiens_hsa030131.77055453
29Steroid biosynthesis_Homo sapiens_hsa001001.76501492
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76464056
31Cell cycle_Homo sapiens_hsa041101.69957301
32Propanoate metabolism_Homo sapiens_hsa006401.56455704
33Staphylococcus aureus infection_Homo sapiens_hsa051501.55219178
34Other glycan degradation_Homo sapiens_hsa005111.52397265
35p53 signaling pathway_Homo sapiens_hsa041151.46296658
36Fatty acid metabolism_Homo sapiens_hsa012121.46074052
37Leishmaniasis_Homo sapiens_hsa051401.43850800
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43338463
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40620073
40Starch and sucrose metabolism_Homo sapiens_hsa005001.38424951
41Folate biosynthesis_Homo sapiens_hsa007901.35780794
42Herpes simplex infection_Homo sapiens_hsa051681.34433846
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32516554
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32209295
45Caffeine metabolism_Homo sapiens_hsa002321.31780345
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.30658856
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.23670861
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22417745
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21177574
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20771145
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18964331
52Phenylalanine metabolism_Homo sapiens_hsa003601.18800804
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18621696
54Legionellosis_Homo sapiens_hsa051341.17123677
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15250265
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.15106041
57Antigen processing and presentation_Homo sapiens_hsa046121.14909947
58Tyrosine metabolism_Homo sapiens_hsa003501.13829678
59Basal transcription factors_Homo sapiens_hsa030221.12903522
60Pyruvate metabolism_Homo sapiens_hsa006201.12722602
61Measles_Homo sapiens_hsa051621.12653339
62Pentose phosphate pathway_Homo sapiens_hsa000301.10310140
63Hematopoietic cell lineage_Homo sapiens_hsa046401.07756026
64RNA degradation_Homo sapiens_hsa030181.06450643
65Bile secretion_Homo sapiens_hsa049761.06398573
66Selenocompound metabolism_Homo sapiens_hsa004501.06307735
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06131120
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.05243375
69Nitrogen metabolism_Homo sapiens_hsa009101.02791612
70Fat digestion and absorption_Homo sapiens_hsa049750.99889347
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99042557
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97066798
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94906674
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92946120
75Fatty acid biosynthesis_Homo sapiens_hsa000610.90927146
76PPAR signaling pathway_Homo sapiens_hsa033200.89621817
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.89589489
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88909889
79Ether lipid metabolism_Homo sapiens_hsa005650.88329882
80Purine metabolism_Homo sapiens_hsa002300.87762557
81Epstein-Barr virus infection_Homo sapiens_hsa051690.86103727
82Carbon metabolism_Homo sapiens_hsa012000.85142974
83Sulfur metabolism_Homo sapiens_hsa009200.82309735
84Apoptosis_Homo sapiens_hsa042100.80868039
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80596568
86Influenza A_Homo sapiens_hsa051640.79879872
87Complement and coagulation cascades_Homo sapiens_hsa046100.79799265
88Vitamin digestion and absorption_Homo sapiens_hsa049770.79198227
89Malaria_Homo sapiens_hsa051440.76702388
90Pertussis_Homo sapiens_hsa051330.76676824
91Galactose metabolism_Homo sapiens_hsa000520.76115371
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74648986
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73682181
94Lysosome_Homo sapiens_hsa041420.73130170
95Osteoclast differentiation_Homo sapiens_hsa043800.73061041
96Systemic lupus erythematosus_Homo sapiens_hsa053220.71906224
97Glutathione metabolism_Homo sapiens_hsa004800.70480608
98Asthma_Homo sapiens_hsa053100.68861984
99Metabolic pathways_Homo sapiens_hsa011000.68681232
100Lysine degradation_Homo sapiens_hsa003100.68447626
101Vitamin B6 metabolism_Homo sapiens_hsa007500.68072380
102Arginine and proline metabolism_Homo sapiens_hsa003300.67196127
103Sphingolipid metabolism_Homo sapiens_hsa006000.66507022
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.65802094
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65092670
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.64554815
107Graft-versus-host disease_Homo sapiens_hsa053320.63544974
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63533956
109Arachidonic acid metabolism_Homo sapiens_hsa005900.63003690
110Primary immunodeficiency_Homo sapiens_hsa053400.62463157
111Small cell lung cancer_Homo sapiens_hsa052220.61384886
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.61081259
113Sulfur relay system_Homo sapiens_hsa041220.60088174
114Allograft rejection_Homo sapiens_hsa053300.59695913
115Tuberculosis_Homo sapiens_hsa051520.59636551
116Fatty acid elongation_Homo sapiens_hsa000620.57991182
117Viral carcinogenesis_Homo sapiens_hsa052030.57709108
118Glycerolipid metabolism_Homo sapiens_hsa005610.55334664
119Hepatitis B_Homo sapiens_hsa051610.54478134
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54182700
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53508419
122Acute myeloid leukemia_Homo sapiens_hsa052210.53111016
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51856455
124mRNA surveillance pathway_Homo sapiens_hsa030150.51502308
125Fructose and mannose metabolism_Homo sapiens_hsa000510.51260582
126Shigellosis_Homo sapiens_hsa051310.50525574
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47519129
128Toxoplasmosis_Homo sapiens_hsa051450.46425848
129B cell receptor signaling pathway_Homo sapiens_hsa046620.46160628
130TNF signaling pathway_Homo sapiens_hsa046680.45535714
131Peroxisome_Homo sapiens_hsa041460.45003333
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44634028
133Renin-angiotensin system_Homo sapiens_hsa046140.42938245
134Regulation of autophagy_Homo sapiens_hsa041400.42604239
135N-Glycan biosynthesis_Homo sapiens_hsa005100.40697611
136Histidine metabolism_Homo sapiens_hsa003400.39622092
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38804792
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38624070
139HTLV-I infection_Homo sapiens_hsa051660.37381463
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37061416
141Biosynthesis of amino acids_Homo sapiens_hsa012300.37029960
142Hepatitis C_Homo sapiens_hsa051600.36523381
143ABC transporters_Homo sapiens_hsa020100.36260756
144beta-Alanine metabolism_Homo sapiens_hsa004100.35798265
145Chemical carcinogenesis_Homo sapiens_hsa052040.35774075
146Phototransduction_Homo sapiens_hsa047440.33684860
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33420756
148Alcoholism_Homo sapiens_hsa050340.27641329
149Ovarian steroidogenesis_Homo sapiens_hsa049130.25175142
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.24720889
151Mineral absorption_Homo sapiens_hsa049780.15476636
152Protein export_Homo sapiens_hsa030600.13122114
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10879791

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