FRS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hippo signaling (GO:0035329)3.94319476
2glucocorticoid receptor signaling pathway (GO:0042921)3.84791075
3insulin-like growth factor receptor signaling pathway (GO:0048009)3.76067287
4NLS-bearing protein import into nucleus (GO:0006607)3.72668185
5pre-miRNA processing (GO:0031054)3.69101726
6presynaptic membrane assembly (GO:0097105)3.58486379
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.58413545
8cytoplasmic mRNA processing body assembly (GO:0033962)3.58054568
9negative regulation of fatty acid transport (GO:2000192)3.36969740
10polarized epithelial cell differentiation (GO:0030859)3.36070967
11plasma membrane repair (GO:0001778)3.25552857
12chondrocyte proliferation (GO:0035988)3.20329217
13mitotic sister chromatid cohesion (GO:0007064)3.18111918
14collagen fibril organization (GO:0030199)3.13108320
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.12800625
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11372910
17protein K11-linked deubiquitination (GO:0035871)3.10546679
18negative regulation of neurotransmitter secretion (GO:0046929)3.10364072
19corticosteroid receptor signaling pathway (GO:0031958)3.05769713
20COPI coating of Golgi vesicle (GO:0048205)3.01682712
21Golgi transport vesicle coating (GO:0048200)3.01682712
22establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.98634331
23negative regulation of keratinocyte proliferation (GO:0010839)2.97548174
24protein localization to endosome (GO:0036010)2.97310250
25regulation of clathrin-mediated endocytosis (GO:2000369)2.95560099
26presynaptic membrane organization (GO:0097090)2.94850185
27pore complex assembly (GO:0046931)2.94408445
28COPII vesicle coating (GO:0048208)2.93972371
29peptidyl-lysine dimethylation (GO:0018027)2.93195528
30adherens junction assembly (GO:0034333)2.91616161
31regulation of transforming growth factor beta2 production (GO:0032909)2.90425185
32regulation of RNA export from nucleus (GO:0046831)2.85090304
33positive regulation of fibroblast migration (GO:0010763)2.82104013
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81538040
35protein heterotrimerization (GO:0070208)2.79122532
36paraxial mesoderm development (GO:0048339)2.78440414
37endodermal cell differentiation (GO:0035987)2.77836841
38regulation of tight junction assembly (GO:2000810)2.77443123
39axon extension involved in axon guidance (GO:0048846)2.72808871
40neuron projection extension involved in neuron projection guidance (GO:1902284)2.72808871
41artery development (GO:0060840)2.72378561
42genitalia morphogenesis (GO:0035112)2.71251222
43regulation of Rac protein signal transduction (GO:0035020)2.69279768
44stress fiber assembly (GO:0043149)2.68846185
45intestinal epithelial cell development (GO:0060576)2.67497738
46negative regulation of catenin import into nucleus (GO:0035414)2.66701166
47craniofacial suture morphogenesis (GO:0097094)2.65140998
48planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64010193
49cell adhesion mediated by integrin (GO:0033627)2.61845764
50locomotory exploration behavior (GO:0035641)2.60323871
51notochord development (GO:0030903)2.58384757
52sequestering of extracellular ligand from receptor (GO:0035581)2.57993638
53endocardial cushion development (GO:0003197)2.57648110
54nuclear pore complex assembly (GO:0051292)2.56874247
55establishment of nucleus localization (GO:0040023)2.56697487
56protein hydroxylation (GO:0018126)2.56679264
57positive regulation of histone deacetylation (GO:0031065)2.56662399
58regulation of nucleobase-containing compound transport (GO:0032239)2.54515213
59cellular response to antibiotic (GO:0071236)2.53929998
60musculoskeletal movement (GO:0050881)2.53312001
61multicellular organismal movement (GO:0050879)2.53312001
62positive regulation of glycogen biosynthetic process (GO:0045725)2.52252367
63morphogenesis of an epithelial sheet (GO:0002011)2.51562898
64prostate gland growth (GO:0060736)2.50658681
65chondrocyte development (GO:0002063)2.50146170
66microtubule anchoring (GO:0034453)2.47015079
67focal adhesion assembly (GO:0048041)2.45522749
68cell-substrate adherens junction assembly (GO:0007045)2.45522749
69bone trabecula formation (GO:0060346)2.45519698
70cell-substrate junction assembly (GO:0007044)2.44943289
71embryonic camera-type eye morphogenesis (GO:0048596)2.44916316
72body morphogenesis (GO:0010171)2.44198067
73peptidyl-proline hydroxylation (GO:0019511)2.43153424
74substrate adhesion-dependent cell spreading (GO:0034446)2.41770524
75embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40971720
76negative regulation of neurotransmitter transport (GO:0051589)2.39915459
77regulation of catenin import into nucleus (GO:0035412)2.39363966
78embryonic cranial skeleton morphogenesis (GO:0048701)2.38624849
79fibroblast migration (GO:0010761)2.38476416
80protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37400973
81regulation of NFAT protein import into nucleus (GO:0051532)2.36945272
82cell migration involved in sprouting angiogenesis (GO:0002042)2.36886368
83mesenchymal-epithelial cell signaling (GO:0060638)2.36762293
84establishment of apical/basal cell polarity (GO:0035089)2.36027174
85phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35216617
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32969374
87epithelial cell-cell adhesion (GO:0090136)2.31884007
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31858009
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31467277
90heart morphogenesis (GO:0003007)2.30972505
91limb bud formation (GO:0060174)2.30816610
92apoptotic cell clearance (GO:0043277)2.30753232
93regulation of cardioblast differentiation (GO:0051890)2.28547618
94embryonic foregut morphogenesis (GO:0048617)2.28517968
95regulation of ARF protein signal transduction (GO:0032012)2.27379521
96negative regulation of chondrocyte differentiation (GO:0032331)2.27321345
97positive regulation of SMAD protein import into nucleus (GO:0060391)2.26366868
98regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.26059731
99negative regulation of DNA repair (GO:0045738)2.25076942
100regulation of keratinocyte proliferation (GO:0010837)2.24635844
101protein localization to cell surface (GO:0034394)2.23947053
102heterochromatin organization (GO:0070828)2.23843231
103nuclear pore organization (GO:0006999)2.23733091
104regulation of translational fidelity (GO:0006450)2.23706882
105heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.23152741
106embryonic body morphogenesis (GO:0010172)2.23039716
107embryonic viscerocranium morphogenesis (GO:0048703)2.22270408
108vascular smooth muscle contraction (GO:0014829)2.21694760
109protein targeting to Golgi (GO:0000042)2.21691290
110sodium ion export (GO:0071436)2.21305770
111cerebral cortex development (GO:0021987)2.21251664
112regulation of establishment of planar polarity (GO:0090175)2.21005735
113regulation of translational termination (GO:0006449)2.20853931
114early endosome to late endosome transport (GO:0045022)2.20454480
115postsynaptic membrane organization (GO:0001941)2.19647903
116synaptic vesicle maturation (GO:0016188)2.19535047
117smooth muscle tissue development (GO:0048745)2.19460224
118positive regulation of nuclease activity (GO:0032075)2.18612276
119regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.18522522
120negative regulation of cell size (GO:0045792)2.17490467
121membrane assembly (GO:0071709)2.17235240
122vesicle coating (GO:0006901)2.16827739
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.16412809
124positive regulation of protein autophosphorylation (GO:0031954)2.16175290
125Golgi to endosome transport (GO:0006895)2.15628668
126regulation of muscle hypertrophy (GO:0014743)2.14403932
127ribonucleoprotein complex disassembly (GO:0032988)2.14227304
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.13767929
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.13767929
130regulation of translation, ncRNA-mediated (GO:0045974)2.13767929
131macroautophagy (GO:0016236)2.13733997
132cell morphogenesis involved in neuron differentiation (GO:0048667)2.13364401
133axis elongation (GO:0003401)2.13239041
134striated muscle atrophy (GO:0014891)2.13173109
135negative regulation of vascular permeability (GO:0043116)2.13020111
136* gastrulation with mouth forming second (GO:0001702)2.12012768
137ER overload response (GO:0006983)2.10608033
138regulation of early endosome to late endosome transport (GO:2000641)2.10449379
139anatomical structure regression (GO:0060033)2.09755271
140sympathetic nervous system development (GO:0048485)2.09212750
141positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.09011944
142righting reflex (GO:0060013)2.08907536
143protein targeting to plasma membrane (GO:0072661)2.08672471
144regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.08649255
145response to gravity (GO:0009629)2.08493078
146cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.08345366
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.07896903
148muscle atrophy (GO:0014889)2.07123287
149regulation of axon extension involved in axon guidance (GO:0048841)2.06617011
150regulation of axon guidance (GO:1902667)2.06232742
151apical protein localization (GO:0045176)2.04832507
152establishment of protein localization to Golgi (GO:0072600)2.03068091
153* anterior/posterior axis specification, embryo (GO:0008595)2.02716109
154dorsal/ventral axis specification (GO:0009950)2.02321706
155mesenchyme morphogenesis (GO:0072132)2.01584870
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.00797953
157chaperone-mediated protein complex assembly (GO:0051131)2.00001083
158asymmetric protein localization (GO:0008105)1.99771985
159negative regulation of signal transduction by p53 class mediator (GO:1901797)1.98858158
160positive regulation of muscle hypertrophy (GO:0014742)1.98471445
161positive regulation of cardiac muscle hypertrophy (GO:0010613)1.98471445
162protein localization to microtubule cytoskeleton (GO:0072698)1.98065155
163monoubiquitinated protein deubiquitination (GO:0035520)1.97954898
164positive regulation of macroautophagy (GO:0016239)1.97122006
165negative regulation of axon guidance (GO:1902668)1.95914433
166cell surface receptor signaling pathway involved in heart development (GO:0061311)1.95698362
167desmosome organization (GO:0002934)1.94605742
168negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)1.94563124
169positive regulation of cell size (GO:0045793)1.94474920
170negative regulation of axon extension involved in axon guidance (GO:0048843)1.94261923
171ganglion development (GO:0061548)1.94217861
172neural tube formation (GO:0001841)1.94187907
173negative regulation of muscle hypertrophy (GO:0014741)1.93661175
174generation of neurons (GO:0048699)1.92962229
175pericardium development (GO:0060039)1.92899041
176Leydig cell differentiation (GO:0033327)1.92750787
177acrosome assembly (GO:0001675)1.92573740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.97489001
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.52410362
3GBX2_23144817_ChIP-Seq_PC3_Human2.72455369
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.48267646
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.47595354
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46631493
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41650320
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40913064
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.39502884
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26393339
11DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.24415518
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.20274496
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.15267982
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10951748
15FUS_26573619_Chip-Seq_HEK293_Human2.10001181
16TAF15_26573619_Chip-Seq_HEK293_Human2.05671245
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.97199519
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.96786251
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96756683
20CLOCK_20551151_ChIP-Seq_293T_Human1.96218490
21* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93605190
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92454159
23* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87984235
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87797447
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87352793
26SMAD4_21799915_ChIP-Seq_A2780_Human1.84914924
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82733327
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82294091
29* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81255703
30* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79695674
31FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79463384
32P300_27058665_Chip-Seq_ZR-75-30cells_Human1.78183134
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73477335
34* P300_19829295_ChIP-Seq_ESCs_Human1.72815293
35KDM2B_26808549_Chip-Seq_DND41_Human1.72475868
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72183048
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71689394
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69357650
39IGF1R_20145208_ChIP-Seq_DFB_Human1.69294482
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68891762
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67113853
42EWS_26573619_Chip-Seq_HEK293_Human1.66981839
43TP53_16413492_ChIP-PET_HCT116_Human1.65092629
44KDM2B_26808549_Chip-Seq_K562_Human1.64390355
45* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.63231059
46BRD4_25478319_ChIP-Seq_HGPS_Human1.62560725
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60947686
48* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60454563
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.59981437
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59797361
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.58505404
52MYC_22102868_ChIP-Seq_BL_Human1.57448869
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.57270632
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.57235898
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.56898393
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56027073
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54364981
58TCF7_22412390_ChIP-Seq_EML_Mouse1.52114284
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.51854102
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51594470
61* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50265424
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49071307
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48690692
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.47293358
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42622950
66ZNF263_19887448_ChIP-Seq_K562_Human1.42489085
67* ISL1_27105846_Chip-Seq_CPCs_Mouse1.41949490
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41348105
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.40169140
70* STAT3_23295773_ChIP-Seq_U87_Human1.39440926
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39295228
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39136457
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38989550
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.38733549
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38669713
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37852972
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37429951
78TP53_18474530_ChIP-ChIP_U2OS_Human1.37266885
79ER_23166858_ChIP-Seq_MCF-7_Human1.37014124
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36325807
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34918606
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33754530
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33003482
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32220744
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.31759738
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31191288
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30892842
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30407086
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29710789
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28643548
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27223202
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26972159
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26615260
94P53_22387025_ChIP-Seq_ESCs_Mouse1.26480024
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26383226
96* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24442307
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.23974615
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.23177930
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22679391
100TP63_17297297_ChIP-ChIP_HaCaT_Human1.22513550
101* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22511054
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21786034
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.21463485
104* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21241005
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20700072
106* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19633317
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.19110982
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18362557
109DROSHA_22980978_ChIP-Seq_HELA_Human1.18111546
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.18106906
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17539376
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17330497
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16172311
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16168128
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15617442
116AR_25329375_ChIP-Seq_VCAP_Human1.15336206
117* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15103888
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15071582
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14506715
120TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14109902
121* TCF4_23295773_ChIP-Seq_U87_Human1.13888694
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13711786
123ZNF274_21170338_ChIP-Seq_K562_Hela1.12824737
124AHR_22903824_ChIP-Seq_MCF-7_Human1.11785141
125WT1_19549856_ChIP-ChIP_CCG9911_Human1.11475023
126* TBX20_22328084_ChIP-Seq_HEART_Mouse1.11299489
127* TBX20_22080862_ChIP-Seq_HEART_Mouse1.11299489
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.11224794
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10986667
130RXR_22108803_ChIP-Seq_LS180_Human1.10744071
131* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10729489
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09868559
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09582467
134SOX9_26525672_Chip-Seq_HEART_Mouse1.09552651
135CJUN_26792858_Chip-Seq_BT549_Human1.09356629
136ATF3_27146783_Chip-Seq_COLON_Human1.09286445
137P300_18555785_Chip-Seq_ESCs_Mouse1.08968801
138TCF4_18268006_ChIP-ChIP_LS174T_Human1.08909871
139CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08878072
140CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08767220
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.08741552
142SOX2_18555785_Chip-Seq_ESCs_Mouse1.08597410
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08011274
144RARB_27405468_Chip-Seq_BRAIN_Mouse1.07749078
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07642787
146CBP_20019798_ChIP-Seq_JUKART_Human1.07642787
147CHD1_26751641_Chip-Seq_LNCaP_Human1.07092307
148* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06883233
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06812854
150PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06350813
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05065616
152* CDX2_22108803_ChIP-Seq_LS180_Human1.04597208
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04591420
154ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04046257
155OCT4_18555785_Chip-Seq_ESCs_Mouse1.03884667
156* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03126783
157GATA1_19941826_ChIP-Seq_K562_Human1.03108711
158NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02863534
159* AR_19668381_ChIP-Seq_PC3_Human1.02862738
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02684267
161RUNX1_27514584_Chip-Seq_MCF-7_Human1.01675621
162RACK7_27058665_Chip-Seq_MCF-7_Human1.01417354
163CREB1_26743006_Chip-Seq_LNCaP_Human1.01413656
164NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99267785
165NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99267785
166PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99169043
167TP53_23651856_ChIP-Seq_MEFs_Mouse0.98828655
168TP53_22127205_ChIP-Seq_IMR90_Human0.97555907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.23665272
2MP0008438_abnormal_cutaneous_collagen4.14773874
3MP0010352_gastrointestinal_tract_polyps3.31867862
4MP0005076_abnormal_cell_differentiation3.08881548
5MP0005623_abnormal_meninges_morphology2.98917546
6MP0005503_abnormal_tendon_morphology2.84969675
7MP0000569_abnormal_digit_pigmentation2.73867699
8MP0005275_abnormal_skin_tensile2.60949943
9MP0009780_abnormal_chondrocyte_physiolo2.54756493
10MP0002877_abnormal_melanocyte_morpholog2.42869690
11MP0008057_abnormal_DNA_replication2.25059678
12MP0003941_abnormal_skin_development2.20948715
13MP0001299_abnormal_eye_distance/2.10949584
14MP0004270_analgesia2.05000985
15MP0003279_aneurysm2.01212097
16MP0004272_abnormal_basement_membrane1.94091880
17MP0009384_cardiac_valve_regurgitation1.93234060
18MP0003566_abnormal_cell_adhesion1.88918458
19MP0003300_gastrointestinal_ulcer1.87971333
20MP0010678_abnormal_skin_adnexa1.84748776
21MP0000428_abnormal_craniofacial_morphol1.84261180
22MP0000427_abnormal_hair_cycle1.82270039
23MP0000733_abnormal_muscle_development1.81888446
24MP0003091_abnormal_cell_migration1.79344461
25MP0003283_abnormal_digestive_organ1.74573441
26MP0001958_emphysema1.73860222
27MP0000383_abnormal_hair_follicle1.69884711
28MP0002009_preneoplasia1.68718479
29MP0004233_abnormal_muscle_weight1.67898759
30MP0002233_abnormal_nose_morphology1.67351277
31MP0004859_abnormal_synaptic_plasticity1.64751065
32MP0010030_abnormal_orbit_morphology1.60754869
33MP0003122_maternal_imprinting1.57722974
34MP0000534_abnormal_ureter_morphology1.54457952
35MP0003385_abnormal_body_wall1.54179001
36MP0003123_paternal_imprinting1.52735948
37MP0004264_abnormal_extraembryonic_tissu1.49920497
38MP0002896_abnormal_bone_mineralization1.48704653
39MP0000003_abnormal_adipose_tissue1.46235307
40MP0003115_abnormal_respiratory_system1.45937434
41MP0002751_abnormal_autonomic_nervous1.44625038
42MP0003045_fibrosis1.42922815
43MP0002938_white_spotting1.41639912
44* MP0004197_abnormal_fetal_growth/weight/1.39307789
45MP0006054_spinal_hemorrhage1.38901605
46MP0005187_abnormal_penis_morphology1.38793900
47MP0005023_abnormal_wound_healing1.36860033
48MP0002108_abnormal_muscle_morphology1.36630174
49MP0009053_abnormal_anal_canal1.35913034
50MP0003942_abnormal_urinary_system1.35741045
51MP0001177_atelectasis1.35366130
52MP0001849_ear_inflammation1.35071975
53MP0000462_abnormal_digestive_system1.33144365
54MP0005508_abnormal_skeleton_morphology1.33081636
55MP0000013_abnormal_adipose_tissue1.32002253
56MP0010368_abnormal_lymphatic_system1.31204637
57MP0010234_abnormal_vibrissa_follicle1.30709573
58* MP0003935_abnormal_craniofacial_develop1.29301567
59MP0001984_abnormal_olfaction1.28230703
60MP0005409_darkened_coat_color1.26043151
61MP0000778_abnormal_nervous_system1.24969311
62MP0005408_hypopigmentation1.24303799
63* MP0002084_abnormal_developmental_patter1.20934957
64MP0004858_abnormal_nervous_system1.20033550
65MP0002925_abnormal_cardiovascular_devel1.19937962
66MP0000537_abnormal_urethra_morphology1.19116273
67MP0003121_genomic_imprinting1.18576743
68* MP0002086_abnormal_extraembryonic_tissu1.18274002
69MP0003567_abnormal_fetal_cardiomyocyte1.17916249
70MP0002234_abnormal_pharynx_morphology1.17727406
71MP0000647_abnormal_sebaceous_gland1.17572549
72MP0008961_abnormal_basal_metabolism1.17017536
73MP0009703_decreased_birth_body1.16735041
74MP0002168_other_aberrant_phenotype1.16697633
75MP0010307_abnormal_tumor_latency1.15614288
76MP0005248_abnormal_Harderian_gland1.15028315
77MP0001286_abnormal_eye_development1.15014822
78MP0010630_abnormal_cardiac_muscle1.14798615
79MP0005257_abnormal_intraocular_pressure1.13550921
80MP0002089_abnormal_postnatal_growth/wei1.11219040
81MP0002088_abnormal_embryonic_growth/wei1.10483749
82MP0004134_abnormal_chest_morphology1.09940950
83MP0005171_absent_coat_pigmentation1.09675639
84MP0001915_intracranial_hemorrhage1.09281888
85MP0003984_embryonic_growth_retardation1.09224243
86MP0003950_abnormal_plasma_membrane1.06984560
87MP0003937_abnormal_limbs/digits/tail_de1.05396291
88MP0003755_abnormal_palate_morphology1.04225098
89MP0000579_abnormal_nail_morphology1.03791709
90MP0009250_abnormal_appendicular_skeleto1.03601497
91MP0004185_abnormal_adipocyte_glucose1.03402845
92MP0001348_abnormal_lacrimal_gland1.02430583
93MP0000762_abnormal_tongue_morphology1.02302184
94* MP0002697_abnormal_eye_size1.00749691
95* MP0000432_abnormal_head_morphology1.00618507
96MP0002098_abnormal_vibrissa_morphology0.98105545
97MP0005375_adipose_tissue_phenotype0.97849404
98MP0004087_abnormal_muscle_fiber0.97580104
99MP0009672_abnormal_birth_weight0.97521117
100MP0002115_abnormal_skeleton_extremities0.96580765
101* MP0000266_abnormal_heart_morphology0.95042679
102MP0002102_abnormal_ear_morphology0.94664437
103MP0001672_abnormal_embryogenesis/_devel0.94194833
104MP0005380_embryogenesis_phenotype0.94194833
105MP0000372_irregular_coat_pigmentation0.93817577
106MP0000767_abnormal_smooth_muscle0.90415931
107MP0001879_abnormal_lymphatic_vessel0.90212623
108MP0002116_abnormal_craniofacial_bone0.89893170
109MP0000377_abnormal_hair_follicle0.89646923
110MP0004808_abnormal_hematopoietic_stem0.89191961
111MP0003890_abnormal_embryonic-extraembry0.88948718
112MP0003943_abnormal_hepatobiliary_system0.88762958
113* MP0001293_anophthalmia0.87018640
114* MP0002085_abnormal_embryonic_tissue0.86758463
115* MP0001697_abnormal_embryo_size0.86449109
116MP0000631_abnormal_neuroendocrine_gland0.85876043
117MP0005367_renal/urinary_system_phenotyp0.85795526
118MP0000516_abnormal_urinary_system0.85795526
119MP0002932_abnormal_joint_morphology0.85728406
120MP0002177_abnormal_outer_ear0.84408909
121MP0003880_abnormal_central_pattern0.84087191
122MP0002254_reproductive_system_inflammat0.83964597
123* MP0003861_abnormal_nervous_system0.83425161
124MP0000163_abnormal_cartilage_morphology0.82767828
125MP0002128_abnormal_blood_circulation0.82619204
126MP0002909_abnormal_adrenal_gland0.82315873
127MP0004885_abnormal_endolymph0.80828265
128MP0001346_abnormal_lacrimal_gland0.80490779
129* MP0002109_abnormal_limb_morphology0.79014519
130MP0004084_abnormal_cardiac_muscle0.78785876
131MP0002060_abnormal_skin_morphology0.78717235
132MP0004130_abnormal_muscle_cell0.78069971
133MP0000639_abnormal_adrenal_gland0.77749471
134MP0002113_abnormal_skeleton_development0.76237720
135MP0003787_abnormal_imprinting0.76217421
136MP0003936_abnormal_reproductive_system0.76033533
137MP0001340_abnormal_eyelid_morphology0.75081827
138MP0001730_embryonic_growth_arrest0.74918650
139MP0001784_abnormal_fluid_regulation0.74898850
140MP0002081_perinatal_lethality0.74587870
141MP0000350_abnormal_cell_proliferation0.74533223
142MP0008770_decreased_survivor_rate0.74046355
143MP0000627_abnormal_mammary_gland0.73913166
144MP0003119_abnormal_digestive_system0.73862013
145MP0005666_abnormal_adipose_tissue0.73333024
146MP0002796_impaired_skin_barrier0.73328043
147MP0001614_abnormal_blood_vessel0.72860199
148MP0002184_abnormal_innervation0.72345122
149MP0005197_abnormal_uvea_morphology0.71965886
150* MP0002092_abnormal_eye_morphology0.70567569
151MP0003221_abnormal_cardiomyocyte_apopto0.70005701
152MP0005253_abnormal_eye_physiology0.69656361

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.34345669
2Shallow orbits (HP:0000586)4.05674109
3Popliteal pterygium (HP:0009756)3.85652588
4Premature rupture of membranes (HP:0001788)3.70295725
5Papillary thyroid carcinoma (HP:0002895)3.53270522
6Cerebral aneurysm (HP:0004944)3.36721040
7Ankle contracture (HP:0006466)3.28310711
8Neoplasm of the adrenal cortex (HP:0100641)3.26165235
9Macroorchidism (HP:0000053)3.21414349
10Fetal akinesia sequence (HP:0001989)3.11334537
11Short 4th metacarpal (HP:0010044)3.09151985
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09151985
13Broad metatarsal (HP:0001783)2.96599257
14Aortic aneurysm (HP:0004942)2.92909122
15Genu recurvatum (HP:0002816)2.77062359
16Cervical subluxation (HP:0003308)2.74148810
17Cystic hygroma (HP:0000476)2.72519738
18Dilatation of the ascending aorta (HP:0005111)2.72173457
19Aplasia of the musculature (HP:0100854)2.70295128
20Aortic dissection (HP:0002647)2.62269940
21Mitral valve prolapse (HP:0001634)2.61023478
22Thyroid carcinoma (HP:0002890)2.58783982
23Bladder diverticulum (HP:0000015)2.57701198
24Spinal cord lesions (HP:0100561)2.56422596
25Syringomyelia (HP:0003396)2.56422596
26Abnormality of the 4th metacarpal (HP:0010012)2.43451549
27Aqueductal stenosis (HP:0002410)2.41531169
28Aneurysm (HP:0002617)2.37719347
29Bowel diverticulosis (HP:0005222)2.37250401
30Exostoses (HP:0100777)2.34114150
31Broad thumb (HP:0011304)2.34025626
32Abnormality of the astrocytes (HP:0100707)2.30754087
33Astrocytoma (HP:0009592)2.30754087
34Narrow palate (HP:0000189)2.29890646
35Curly hair (HP:0002212)2.29156550
36Enlarged penis (HP:0000040)2.26572279
37Peritonitis (HP:0002586)2.25929474
38Hypoplastic ischia (HP:0003175)2.22098372
39Deep philtrum (HP:0002002)2.21366351
40Hepatoblastoma (HP:0002884)2.17652976
41Pheochromocytoma (HP:0002666)2.15797126
42Deviation of the hallux (HP:0010051)2.14287664
43Intestinal atresia (HP:0011100)2.14282074
44Volvulus (HP:0002580)2.13956400
45Atrophic scars (HP:0001075)2.12991866
46Glioma (HP:0009733)2.12592138
47Turricephaly (HP:0000262)2.12349527
48Long eyelashes (HP:0000527)2.10243657
49Trigonocephaly (HP:0000243)2.10111175
50Rhabdomyosarcoma (HP:0002859)2.08029301
51Asymmetry of the thorax (HP:0001555)2.06658354
52Broad long bones (HP:0005622)2.04716784
53Long clavicles (HP:0000890)2.04350583
54Hallux valgus (HP:0001822)2.04200388
55Hyperacusis (HP:0010780)2.02627789
56Upper limb amyotrophy (HP:0009129)2.02221241
57Distal upper limb amyotrophy (HP:0007149)2.02221241
58Vascular tortuosity (HP:0004948)2.01200052
59Renal duplication (HP:0000075)2.00122238
60Subacute progressive viral hepatitis (HP:0006572)1.99463437
61Large earlobe (HP:0009748)1.99248043
62Abnormality of the labia majora (HP:0012881)1.99198934
63Neoplasm of the adrenal gland (HP:0100631)1.98148548
64Neonatal respiratory distress (HP:0002643)1.97447000
65Osteomalacia (HP:0002749)1.95778600
66Ulnar bowing (HP:0003031)1.94847583
67Absent frontal sinuses (HP:0002688)1.91378017
68Dysmetric saccades (HP:0000641)1.91298622
69Broad phalanx (HP:0006009)1.91067954
70Abnormality of the ischium (HP:0003174)1.91014843
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90591792
72Coronal craniosynostosis (HP:0004440)1.90488519
73Broad phalanges of the hand (HP:0009768)1.90013960
74Renovascular hypertension (HP:0100817)1.89757128
75Neoplasm of the thyroid gland (HP:0100031)1.88850393
76Abnormality of placental membranes (HP:0011409)1.87549122
77Amniotic constriction ring (HP:0009775)1.87549122
78Akinesia (HP:0002304)1.86909106
79Heterotopia (HP:0002282)1.85069066
80Pulmonic stenosis (HP:0001642)1.84996674
81Blue sclerae (HP:0000592)1.84347968
82Joint laxity (HP:0001388)1.84277986
83Obsessive-compulsive behavior (HP:0000722)1.84174249
84Broad finger (HP:0001500)1.83787591
85Midline defect of the nose (HP:0004122)1.83517930
86Drooling (HP:0002307)1.83214544
87Hyperextensible skin (HP:0000974)1.83117555
88Arterial tortuosity (HP:0005116)1.82817879
89Striae distensae (HP:0001065)1.82776369
90Lymphangioma (HP:0100764)1.81447502
91Soft skin (HP:0000977)1.80406161
92Wormian bones (HP:0002645)1.78685981
93Wide anterior fontanel (HP:0000260)1.78116215
94Buphthalmos (HP:0000557)1.78073980
95Hip dysplasia (HP:0001385)1.78012318
96Overgrowth (HP:0001548)1.77433779
97Medulloblastoma (HP:0002885)1.76430734
98Vertebral arch anomaly (HP:0008438)1.76043958
99Genetic anticipation (HP:0003743)1.74876016
100Mildly elevated creatine phosphokinase (HP:0008180)1.73586280
101Menstrual irregularities (HP:0000858)1.73229129
102Proximal tubulopathy (HP:0000114)1.72888701
103Osteolytic defects of the hand bones (HP:0009699)1.72613967
104Osteolytic defects of the phalanges of the hand (HP:0009771)1.72613967
105Deviation of the thumb (HP:0009603)1.71974119
106Increased nuchal translucency (HP:0010880)1.71754610
107Disproportionate tall stature (HP:0001519)1.71702617
108Increased number of teeth (HP:0011069)1.71652085
109Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71449571
110Hand muscle atrophy (HP:0009130)1.71226100
111Ankyloglossia (HP:0010296)1.71057125
112Broad palm (HP:0001169)1.70784572
113Pterygium (HP:0001059)1.70641219
114Thin bony cortex (HP:0002753)1.70431016
115Mesomelia (HP:0003027)1.70244703
116Hamartoma of the eye (HP:0010568)1.70201913
117Freckling (HP:0001480)1.69540927
118Neoplasm of the heart (HP:0100544)1.69366351
119Spondylolisthesis (HP:0003302)1.68701510
120Hypoplastic labia majora (HP:0000059)1.68115315
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67059188
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.66962318
123Hypoplasia of the maxilla (HP:0000327)1.66309061
124Fragile skin (HP:0001030)1.66075518
125Follicular hyperkeratosis (HP:0007502)1.66010470
126Breast carcinoma (HP:0003002)1.65393684
127Bell-shaped thorax (HP:0001591)1.63897664
128Insidious onset (HP:0003587)1.63820442
129Termporal pattern (HP:0011008)1.63820442
130Broad face (HP:0000283)1.63567246
131Hypoplasia of the iris (HP:0007676)1.63156701
132Pointed chin (HP:0000307)1.62985529
133Cutaneous finger syndactyly (HP:0010554)1.61975555
134Abnormal auditory evoked potentials (HP:0006958)1.61399840
135Bifid tongue (HP:0010297)1.61043609
136Absent eyebrow (HP:0002223)1.60670579
137Abnormality of oral frenula (HP:0000190)1.60350615
138Abnormality of the epiphyses of the hand (HP:0005924)1.60336116
139Cubitus valgus (HP:0002967)1.60335715
140Increased density of long bones (HP:0006392)1.59835516
141Microglossia (HP:0000171)1.59832413
142Transitional cell carcinoma of the bladder (HP:0006740)1.59680828
143Truncal obesity (HP:0001956)1.59370170
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58927093
145Abnormality of the nasal septum (HP:0000419)1.58888846
146Wrist flexion contracture (HP:0001239)1.58827296
147Febrile seizures (HP:0002373)1.58398431
148Radial bowing (HP:0002986)1.57347495
149Insomnia (HP:0100785)1.56284104
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.56015669
151Neuroendocrine neoplasm (HP:0100634)1.55684705
152Dislocated radial head (HP:0003083)1.55197369
153Hamartoma (HP:0010566)1.54861655
154Neoplasm of striated muscle (HP:0009728)1.54496889
155Abnormality of the fingertips (HP:0001211)1.54370506
156Excessive salivation (HP:0003781)1.54267861
157Genital tract atresia (HP:0001827)1.53955057
158Fibrous tissue neoplasm (HP:0012316)1.53853160
159Fibroma (HP:0010614)1.53608242
160Nephroblastoma (Wilms tumor) (HP:0002667)1.53527696
161Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.53477314
162Blue irides (HP:0000635)1.53365943
163Short metatarsal (HP:0010743)1.53328351
164Vertebral clefting (HP:0008428)1.53300598
165Anal stenosis (HP:0002025)1.53062163
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52188534
167Embryonal renal neoplasm (HP:0011794)1.51987906
168Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.51986170
169Pectus excavatum (HP:0000767)1.50817561
170Depressed nasal tip (HP:0000437)1.50774510
171Abnormality of the phalanges of the 2nd finger (HP:0009541)1.49792124
172Widely spaced teeth (HP:0000687)1.49709791
173Vaginal atresia (HP:0000148)1.48969909
174Sparse lateral eyebrow (HP:0005338)1.48716765
175Diminished movement (HP:0002374)1.48622201
176Tubulointerstitial nephritis (HP:0001970)1.47970977
177Abnormality of the frontal sinuses (HP:0002687)1.47697333
178Hyperventilation (HP:0002883)1.46200575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.77699582
2TRIB33.45613110
3DDR23.31106711
4CASK3.29504048
5LATS13.01844039
6PDGFRA3.00306842
7STK38L2.71046866
8PKN22.47561718
9SIK12.23705798
10TRIM282.18929121
11LATS22.18138677
12TTN2.03561585
13RIPK11.98397949
14PRKD31.95776137
15STK31.94072832
16BCR1.91701442
17CAMK1D1.89962294
18PTK61.88439036
19EEF2K1.87702498
20DMPK1.86429860
21CAMK1G1.77701084
22TNIK1.74968870
23EIF2AK31.70529553
24YES11.63137276
25FGFR21.61414817
26NEK91.57268074
27MTOR1.55617970
28PNCK1.55524594
29SCYL21.53971026
30MAP3K101.46746488
31CAMKK11.44218807
32BMX1.40434588
33TYRO31.37982467
34CDK61.37660360
35RET1.35884441
36PDGFRB1.34243057
37TAOK11.32855176
38PTK21.32765645
39NTRK21.32562379
40ERBB41.28559643
41BRD41.26944807
42WEE11.26718272
43RPS6KB11.24685016
44PAK31.22661454
45MAP3K91.21683539
46* FGFR11.20938231
47PAK21.20285334
48MKNK21.15727995
49PBK1.14925533
50STK391.14236343
51ALK1.13492717
52FRK1.09486883
53ERN11.07719391
54WNK11.07253864
55WNK31.06754955
56PRKCH1.04460980
57MET1.04451349
58ICK1.04127595
59PAK61.02136592
60KSR21.00779402
61SGK31.00207811
62NTRK10.99802802
63NLK0.99257060
64NEK10.97929858
65SGK4940.92902846
66SGK2230.92902846
67FGFR30.92692018
68STK380.91580051
69EIF2AK10.91549354
70CSNK1G10.91253223
71MAP3K20.91077203
72CDC42BPA0.89794767
73NEK60.85116305
74PIK3CA0.83053985
75STK240.79922968
76PLK20.77968506
77BMPR1B0.77464430
78CAMKK20.77195562
79TSSK60.76226244
80CDK30.74370842
81MARK10.74119117
82PRKCE0.73359620
83MAP3K70.71117695
84KSR10.70507701
85LRRK20.69868032
86ERBB30.69224894
87NTRK30.68044274
88MUSK0.67562736
89BRSK20.66740429
90MAP3K40.66676060
91CSNK1G20.65298701
92TAOK30.64445679
93DYRK1A0.64148929
94MAP3K120.64058717
95NEK20.63266279
96SRPK10.60670100
97MAP2K70.60258054
98CSNK1A1L0.59875477
99EIF2AK20.59776494
100SIK30.58118908
101MKNK10.53891486
102JAK10.53378219
103MAPK100.52437668
104PRKAA10.52030263
105OBSCN0.51991997
106ERBB20.51742935
107PLK10.51521047
108TAF10.50751060
109DYRK30.50620233
110FER0.50577825
111MINK10.50371283
112ROCK10.50193841
113MST40.49433907
114STK110.48925526
115CDK40.47178342
116EPHB20.47121848
117CSNK1D0.46979282
118SIK20.46901227
119SGK20.46252736
120RPS6KA40.45746983
121CHUK0.45688967
122MAP2K40.44899891
123BRSK10.44443580
124CAMK40.44037843
125NUAK10.43900617
126CDK90.43850821
127STK100.43075452
128CSNK1G30.43055656
129TTK0.42357590
130ATM0.42155438
131RPS6KA20.42020504
132MAPK10.41442079
133PDK20.41172351
134PRKD20.39942718
135CHEK10.39500037
136PRKD10.39347552
137MAPK80.39064466
138SGK10.39039355
139MARK20.38498488
140ROCK20.38272128
141MELK0.38170920
142PTK2B0.37453052
143CDK20.37282060
144MAPK140.37257684
145CDK70.36515713
146RPS6KA30.36018344
147IRAK10.35220867
148MAPK70.34764886
149GSK3A0.34503559
150GSK3B0.34387968
151EPHA30.33992449
152PAK40.33544253
153AKT30.32913925
154MAP3K50.32474579
155PLK30.31960862
156PRKDC0.31812200
157EGFR0.31499258

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.36986224
2Nitrogen metabolism_Homo sapiens_hsa009102.34385526
3mTOR signaling pathway_Homo sapiens_hsa041501.87108757
4Focal adhesion_Homo sapiens_hsa045101.70115764
5* Proteoglycans in cancer_Homo sapiens_hsa052051.68704097
6ECM-receptor interaction_Homo sapiens_hsa045121.66203683
7Adherens junction_Homo sapiens_hsa045201.63469962
8Inositol phosphate metabolism_Homo sapiens_hsa005621.54947162
9Glioma_Homo sapiens_hsa052141.54750456
10Chronic myeloid leukemia_Homo sapiens_hsa052201.54304845
11MicroRNAs in cancer_Homo sapiens_hsa052061.48201111
12Hippo signaling pathway_Homo sapiens_hsa043901.46500986
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43212946
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.39841427
15Lysine degradation_Homo sapiens_hsa003101.39268698
16Type II diabetes mellitus_Homo sapiens_hsa049301.38727946
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35905969
18Endometrial cancer_Homo sapiens_hsa052131.33505490
19p53 signaling pathway_Homo sapiens_hsa041151.32556004
20Small cell lung cancer_Homo sapiens_hsa052221.29832468
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29575934
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24191627
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22822046
24Amoebiasis_Homo sapiens_hsa051461.21670196
25Dorso-ventral axis formation_Homo sapiens_hsa043201.21373696
26Long-term potentiation_Homo sapiens_hsa047201.21284272
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19547338
28* Neurotrophin signaling pathway_Homo sapiens_hsa047221.19031978
29Propanoate metabolism_Homo sapiens_hsa006401.18693564
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17892572
31Dilated cardiomyopathy_Homo sapiens_hsa054141.17143693
32Basal cell carcinoma_Homo sapiens_hsa052171.16441063
33Estrogen signaling pathway_Homo sapiens_hsa049151.15052479
34Colorectal cancer_Homo sapiens_hsa052101.14641516
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14044239
36TGF-beta signaling pathway_Homo sapiens_hsa043501.12558906
37Non-small cell lung cancer_Homo sapiens_hsa052231.12502835
38Hedgehog signaling pathway_Homo sapiens_hsa043401.11874236
39GABAergic synapse_Homo sapiens_hsa047271.11619712
40Bladder cancer_Homo sapiens_hsa052191.11288253
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.10463681
42Insulin resistance_Homo sapiens_hsa049311.10333358
43Renal cell carcinoma_Homo sapiens_hsa052111.10151136
44Glutamatergic synapse_Homo sapiens_hsa047241.09772260
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09296853
46Prostate cancer_Homo sapiens_hsa052151.08288057
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07926941
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05008591
49Pancreatic cancer_Homo sapiens_hsa052121.04607953
50ErbB signaling pathway_Homo sapiens_hsa040121.04327675
51Protein export_Homo sapiens_hsa030601.02203262
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01651126
53Gap junction_Homo sapiens_hsa045401.00792725
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00264574
55Sulfur metabolism_Homo sapiens_hsa009200.99737844
56Melanogenesis_Homo sapiens_hsa049160.99673315
57Sphingolipid metabolism_Homo sapiens_hsa006000.98427457
58Wnt signaling pathway_Homo sapiens_hsa043100.96130897
59Steroid biosynthesis_Homo sapiens_hsa001000.95603426
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94995744
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94969623
62AMPK signaling pathway_Homo sapiens_hsa041520.93511414
63Long-term depression_Homo sapiens_hsa047300.93261429
64Insulin signaling pathway_Homo sapiens_hsa049100.93024001
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92722937
66GnRH signaling pathway_Homo sapiens_hsa049120.92586399
67Insulin secretion_Homo sapiens_hsa049110.90426141
68Amphetamine addiction_Homo sapiens_hsa050310.88826768
69Rap1 signaling pathway_Homo sapiens_hsa040150.87169713
70Oocyte meiosis_Homo sapiens_hsa041140.86625284
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86411798
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85850879
73Caffeine metabolism_Homo sapiens_hsa002320.85576504
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84482021
75Melanoma_Homo sapiens_hsa052180.83627056
76FoxO signaling pathway_Homo sapiens_hsa040680.82983284
77Basal transcription factors_Homo sapiens_hsa030220.82613640
78Cell cycle_Homo sapiens_hsa041100.82367044
79Glucagon signaling pathway_Homo sapiens_hsa049220.82030582
80VEGF signaling pathway_Homo sapiens_hsa043700.81754805
81Cocaine addiction_Homo sapiens_hsa050300.80825101
82Oxytocin signaling pathway_Homo sapiens_hsa049210.80822810
83Nicotine addiction_Homo sapiens_hsa050330.80466675
84Platelet activation_Homo sapiens_hsa046110.80107840
85Non-homologous end-joining_Homo sapiens_hsa034500.79827159
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.79250558
87Thyroid hormone synthesis_Homo sapiens_hsa049180.79071494
88Dopaminergic synapse_Homo sapiens_hsa047280.78055264
89Pathways in cancer_Homo sapiens_hsa052000.77934042
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77850001
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77774535
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77371778
93Cholinergic synapse_Homo sapiens_hsa047250.77352185
94Tight junction_Homo sapiens_hsa045300.75925457
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75324314
96Gastric acid secretion_Homo sapiens_hsa049710.75104231
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74769635
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74647314
99Selenocompound metabolism_Homo sapiens_hsa004500.74628244
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74107519
101Toxoplasmosis_Homo sapiens_hsa051450.73480607
102Thyroid cancer_Homo sapiens_hsa052160.73448953
103Endocytosis_Homo sapiens_hsa041440.73444814
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73203928
105Protein digestion and absorption_Homo sapiens_hsa049740.72227204
106Ovarian steroidogenesis_Homo sapiens_hsa049130.71554951
107Viral myocarditis_Homo sapiens_hsa054160.70750160
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70723938
109Taste transduction_Homo sapiens_hsa047420.70586379
110cAMP signaling pathway_Homo sapiens_hsa040240.70464165
111Choline metabolism in cancer_Homo sapiens_hsa052310.70159124
112MAPK signaling pathway_Homo sapiens_hsa040100.69134928
113Axon guidance_Homo sapiens_hsa043600.69103122
114HTLV-I infection_Homo sapiens_hsa051660.68350085
115Circadian entrainment_Homo sapiens_hsa047130.67980622
116Hepatitis B_Homo sapiens_hsa051610.66774308
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.66696069
118HIF-1 signaling pathway_Homo sapiens_hsa040660.63875060
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63850461
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.63821122
121Salivary secretion_Homo sapiens_hsa049700.62537955
122Prolactin signaling pathway_Homo sapiens_hsa049170.62295329
123Vibrio cholerae infection_Homo sapiens_hsa051100.61589962
124Renin secretion_Homo sapiens_hsa049240.61439939
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61276128
126Morphine addiction_Homo sapiens_hsa050320.60558015
127mRNA surveillance pathway_Homo sapiens_hsa030150.58768328
128Butanoate metabolism_Homo sapiens_hsa006500.58660348
129Pancreatic secretion_Homo sapiens_hsa049720.55927648
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.55219362

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