FRYL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)4.88941804
2rhodopsin mediated signaling pathway (GO:0016056)4.85381346
3histone H3-K4 trimethylation (GO:0080182)4.48422525
4retinal cone cell development (GO:0046549)4.45966125
5neural tube formation (GO:0001841)4.45864027
6interkinetic nuclear migration (GO:0022027)4.30656956
7regulation of pigment cell differentiation (GO:0050932)4.22049688
8monoubiquitinated protein deubiquitination (GO:0035520)3.88285018
9eye photoreceptor cell differentiation (GO:0001754)3.88222974
10photoreceptor cell differentiation (GO:0046530)3.88222974
11detection of light stimulus involved in visual perception (GO:0050908)3.86066618
12detection of light stimulus involved in sensory perception (GO:0050962)3.86066618
13photoreceptor cell maintenance (GO:0045494)3.82589631
14axon ensheathment in central nervous system (GO:0032291)3.77099165
15central nervous system myelination (GO:0022010)3.77099165
16nucleus localization (GO:0051647)3.66528670
17cellular response to ethanol (GO:0071361)3.65599278
18negative regulation of neurotransmitter transport (GO:0051589)3.63433356
19cytoplasmic mRNA processing body assembly (GO:0033962)3.62264432
20cerebellar Purkinje cell differentiation (GO:0021702)3.54933976
21establishment of nucleus localization (GO:0040023)3.53733490
22positive regulation of developmental pigmentation (GO:0048087)3.49957487
23positive regulation of gamma-delta T cell activation (GO:0046645)3.42845714
24microtubule anchoring (GO:0034453)3.37222934
25activated T cell proliferation (GO:0050798)3.35534685
26photoreceptor cell development (GO:0042461)3.30803296
27eye photoreceptor cell development (GO:0042462)3.29631596
28protein K11-linked deubiquitination (GO:0035871)3.19472421
29lipid translocation (GO:0034204)3.19245094
30phospholipid translocation (GO:0045332)3.19245094
31positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.15986006
32regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.15986006
33histone H3-K4 methylation (GO:0051568)3.10399516
34peptidyl-lysine methylation (GO:0018022)3.09829552
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.06916065
36negative regulation of cell killing (GO:0031342)3.06916065
37regulation of protein glycosylation (GO:0060049)3.04013006
38negative T cell selection (GO:0043383)3.03227888
39histone H3-K9 methylation (GO:0051567)3.00617162
40regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.00600025
41positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.00600025
42positive thymic T cell selection (GO:0045059)3.00167612
43regulation of establishment of cell polarity (GO:2000114)3.00049624
44histone H3-K9 modification (GO:0061647)2.98586801
45histone mRNA catabolic process (GO:0071044)2.98218688
46ensheathment of neurons (GO:0007272)2.96948301
47axon ensheathment (GO:0008366)2.96948301
48protein K48-linked deubiquitination (GO:0071108)2.96255343
49positive T cell selection (GO:0043368)2.95571156
50peptidyl-lysine trimethylation (GO:0018023)2.93447586
51negative thymic T cell selection (GO:0045060)2.92284044
52myelination (GO:0042552)2.90334070
53positive regulation of granulocyte differentiation (GO:0030854)2.86438112
54regulation of protein polyubiquitination (GO:1902914)2.85395291
55protein targeting to vacuole (GO:0006623)2.84912295
56protein targeting to lysosome (GO:0006622)2.84912295
57establishment of protein localization to vacuole (GO:0072666)2.84912295
58protein localization to endosome (GO:0036010)2.83697050
59regulation of gamma-delta T cell differentiation (GO:0045586)2.80007224
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77209061
61nuclear pore complex assembly (GO:0051292)2.71756665
62peptidyl-tyrosine autophosphorylation (GO:0038083)2.70489930
63olfactory bulb development (GO:0021772)2.69999123
64retinal rod cell development (GO:0046548)2.69984528
65thymic T cell selection (GO:0045061)2.68193295
66negative regulation of neurotransmitter secretion (GO:0046929)2.68170544
67nerve growth factor signaling pathway (GO:0038180)2.67833869
68presynaptic membrane assembly (GO:0097105)2.67726242
69cortical actin cytoskeleton organization (GO:0030866)2.67645457
70regulation of ARF protein signal transduction (GO:0032012)2.67597995
71T cell selection (GO:0045058)2.67087075
72protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.66623010
73myelin maintenance (GO:0043217)2.66117077
74presynaptic membrane organization (GO:0097090)2.65957030
75asymmetric protein localization (GO:0008105)2.65226808
76detection of light stimulus (GO:0009583)2.65033000
77regulation of B cell receptor signaling pathway (GO:0050855)2.63921554
78regulation of mRNA catabolic process (GO:0061013)2.63221513
79phototransduction (GO:0007602)2.62384790
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61902752
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.61902752
82regulation of translation, ncRNA-mediated (GO:0045974)2.61902752
83regulation of T cell tolerance induction (GO:0002664)2.61256877
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60768556
85histone H3-K36 demethylation (GO:0070544)2.59092642
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58860277
87labyrinthine layer development (GO:0060711)2.56067745
88positive regulation of mRNA catabolic process (GO:0061014)2.55828626
89regulation of establishment or maintenance of cell polarity (GO:0032878)2.55348727
90detection of visible light (GO:0009584)2.55261586
91regulation of gamma-delta T cell activation (GO:0046643)2.55203096
92protein-chromophore linkage (GO:0018298)2.54772574
93tolerance induction (GO:0002507)2.54734755
94pericardium development (GO:0060039)2.54051819
95early endosome to late endosome transport (GO:0045022)2.54010572
96glial cell proliferation (GO:0014009)2.51729161
97nuclear pore organization (GO:0006999)2.51001906
98negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.50714543
99visual perception (GO:0007601)2.48727700
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48698381
101central nervous system neuron axonogenesis (GO:0021955)2.48388936
102sensory perception of light stimulus (GO:0050953)2.47360571
103protein targeting to Golgi (GO:0000042)2.46234836
104T-helper cell differentiation (GO:0042093)2.42295599
105CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42295599
106phototransduction, visible light (GO:0007603)2.42265528
107limb bud formation (GO:0060174)2.41161749
108embryonic camera-type eye morphogenesis (GO:0048596)2.39382521
109Golgi to endosome transport (GO:0006895)2.39161679
110central nervous system projection neuron axonogenesis (GO:0021952)2.38888392
111definitive hemopoiesis (GO:0060216)2.38675149
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.36904773
113interferon-gamma production (GO:0032609)2.36789831
114hepatocyte apoptotic process (GO:0097284)2.34258310
115leukocyte aggregation (GO:0070486)2.34236344
116cortical cytoskeleton organization (GO:0030865)2.33731008
117interleukin-6-mediated signaling pathway (GO:0070102)2.33719360
118embryonic hemopoiesis (GO:0035162)2.33393762
119regulation of membrane lipid distribution (GO:0097035)2.32469185
120heterotypic cell-cell adhesion (GO:0034113)2.31332855
121positive regulation of histone deacetylation (GO:0031065)2.31089322
122negative regulation of DNA repair (GO:0045738)2.30957293
123establishment of protein localization to Golgi (GO:0072600)2.30447511
124import into cell (GO:0098657)2.29495311
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.28187672
126regulation of growth hormone secretion (GO:0060123)2.27159564
127protein localization to Golgi apparatus (GO:0034067)2.27029571
128positive regulation of guanylate cyclase activity (GO:0031284)2.26694679
129intra-Golgi vesicle-mediated transport (GO:0006891)2.26689482
130CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.25390604
131pre-miRNA processing (GO:0031054)2.24981610
132positive regulation of interleukin-2 production (GO:0032743)2.24920574
133positive regulation of DNA-templated transcription, initiation (GO:2000144)2.24343686
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23926008
135positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.22540062
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.20843475
137response to interleukin-15 (GO:0070672)2.20684847
138retina layer formation (GO:0010842)2.20648524
139centrosome localization (GO:0051642)2.20144383
140embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20114340
141apical protein localization (GO:0045176)2.19920293
142T cell costimulation (GO:0031295)2.19022328
143histone lysine methylation (GO:0034968)2.18875582
144regulation of developmental pigmentation (GO:0048070)2.17529362
145myelin assembly (GO:0032288)2.16041930
146lymphocyte costimulation (GO:0031294)2.16031983
147cellular response to interleukin-15 (GO:0071350)2.14162055
148peptidyl-threonine phosphorylation (GO:0018107)2.13150147
149histone H3-K9 demethylation (GO:0033169)2.12536260
150regulation of interleukin-12 biosynthetic process (GO:0045075)2.12511877
151adaptation of signaling pathway (GO:0023058)2.12478058
152cyclic nucleotide catabolic process (GO:0009214)2.11489818
153B cell receptor signaling pathway (GO:0050853)2.11257940
154T cell differentiation involved in immune response (GO:0002292)2.11243087
155alpha-beta T cell differentiation involved in immune response (GO:0002293)2.11243087
156alpha-beta T cell activation involved in immune response (GO:0002287)2.11243087
157prenylation (GO:0097354)2.10969615
158protein prenylation (GO:0018342)2.10969615
159phosphatidylinositol phosphorylation (GO:0046854)2.09999729
160axonal fasciculation (GO:0007413)2.09840255
161pore complex assembly (GO:0046931)2.09335229
162L-amino acid import (GO:0043092)2.08910378
163regulation of voltage-gated calcium channel activity (GO:1901385)2.08504020
164T cell receptor signaling pathway (GO:0050852)2.08214846
165potassium ion import (GO:0010107)2.07049746
166cAMP catabolic process (GO:0006198)2.06868923
167positive regulation of tolerance induction (GO:0002645)2.06327153
168mitotic sister chromatid cohesion (GO:0007064)2.06095031
169protein K63-linked deubiquitination (GO:0070536)2.05339125
170negative regulation of dendrite development (GO:2000171)2.05121470
171alpha-beta T cell differentiation (GO:0046632)2.04616954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.16437101
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33851198
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.95070150
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.85464410
5RUNX_20019798_ChIP-Seq_JUKART_Human2.70449779
6IGF1R_20145208_ChIP-Seq_DFB_Human2.30911701
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.25601200
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22810877
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15277324
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.00770394
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92373390
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91411044
13DROSHA_22980978_ChIP-Seq_HELA_Human1.91184654
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88741349
15FUS_26573619_Chip-Seq_HEK293_Human1.85401930
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84504907
17AR_21572438_ChIP-Seq_LNCaP_Human1.79469119
18GBX2_23144817_ChIP-Seq_PC3_Human1.78943471
19P300_19829295_ChIP-Seq_ESCs_Human1.77158524
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75829710
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75749608
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63761817
23AHR_22903824_ChIP-Seq_MCF-7_Human1.63145506
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55646048
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.55572795
26ER_23166858_ChIP-Seq_MCF-7_Human1.55230548
27EWS_26573619_Chip-Seq_HEK293_Human1.51551291
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49446946
29GATA1_19941826_ChIP-Seq_K562_Human1.47318044
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46942196
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.45029251
32SCL_19346495_ChIP-Seq_HPC-7_Human1.44630810
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44408198
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43640122
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42898175
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42277708
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42102514
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.41878206
39CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40787232
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.40540466
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40455485
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40119029
43TP53_16413492_ChIP-PET_HCT116_Human1.39230445
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37964925
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.37492446
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37216901
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35612839
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33558457
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32539035
50P53_22387025_ChIP-Seq_ESCs_Mouse1.31645622
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31454141
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31428463
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31356627
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.30910574
55KDM2B_26808549_Chip-Seq_DND41_Human1.30606683
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30384750
57CBP_20019798_ChIP-Seq_JUKART_Human1.30384750
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.30002410
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.29695002
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29560154
61VDR_22108803_ChIP-Seq_LS180_Human1.29531631
62AR_25329375_ChIP-Seq_VCAP_Human1.28919357
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.28894671
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28416547
65GATA1_22025678_ChIP-Seq_K562_Human1.28172040
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27852698
67* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26567291
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25028104
69ZNF274_21170338_ChIP-Seq_K562_Hela1.24765218
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24692709
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24483551
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24397069
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.23855453
74* FOXO3_23340844_ChIP-Seq_DLD1_Human1.23481149
75* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23406120
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23396232
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23364249
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23364249
79* STAT3_23295773_ChIP-Seq_U87_Human1.22521415
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21525616
81BCAT_22108803_ChIP-Seq_LS180_Human1.21191823
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20071025
83SPI1_23127762_ChIP-Seq_K562_Human1.19703043
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.19526594
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18131930
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.17463656
87VDR_24787735_ChIP-Seq_THP-1_Human1.17384221
88MYB_26560356_Chip-Seq_TH2_Human1.16050979
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15291615
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14188957
91CDX2_22108803_ChIP-Seq_LS180_Human1.14061842
92P300_18555785_Chip-Seq_ESCs_Mouse1.14043871
93TCF4_23295773_ChIP-Seq_U87_Human1.13032113
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12906737
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10538418
96RUNX2_22187159_ChIP-Seq_PCA_Human1.10530728
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09598882
98* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09099444
99KDM2B_26808549_Chip-Seq_K562_Human1.08988949
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08750631
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08512766
102* TCF7_22412390_ChIP-Seq_EML_Mouse1.08300804
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08231385
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.08225305
105KDM2B_26808549_Chip-Seq_REH_Human1.07423392
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07296069
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07270580
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.07094492
109* GATA2_19941826_ChIP-Seq_K562_Human1.06455676
110RXR_22108803_ChIP-Seq_LS180_Human1.06343226
111TCF4_22108803_ChIP-Seq_LS180_Human1.06005223
112SMAD4_21799915_ChIP-Seq_A2780_Human1.05903920
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05743244
114* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05693756
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05361891
116* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05103258
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04272659
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03934187
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.03929626
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03517792
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03266935
122GATA3_27048872_Chip-Seq_THYMUS_Human1.02476351
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.02145741
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.01723409
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.01720457
126* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00918054
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99702711
128MYB_26560356_Chip-Seq_TH1_Human0.99557968
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.98787095
130* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97140543
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.97081864
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96020106
133UTX_26944678_Chip-Seq_JUKART_Human0.95990766
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.95802507
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.95652135
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95364015
137* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95162784
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.93759098
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93376712
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93376712
141TBL1_22424771_ChIP-Seq_293T_Human0.93347929
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93347023
143MAF_26560356_Chip-Seq_TH1_Human0.93271856
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92723794
145* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91808933
146* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91723495
147RARB_27405468_Chip-Seq_BRAIN_Mouse0.91522263
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91501426
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.91455711
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91249132
151AR_19668381_ChIP-Seq_PC3_Human0.90705386
152TAF15_26573619_Chip-Seq_HEK293_Human0.90370766
153IRF8_27001747_Chip-Seq_BMDM_Mouse0.89861701
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89798764
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.89776905
156SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89421931
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88876198
158* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88652485
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88359841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.75663746
2MP0003950_abnormal_plasma_membrane3.91458660
3MP0000569_abnormal_digit_pigmentation3.66092296
4MP0005253_abnormal_eye_physiology3.34102615
5MP0006072_abnormal_retinal_apoptosis3.20604548
6MP0003300_gastrointestinal_ulcer2.79770233
7MP0000920_abnormal_myelination2.73658073
8MP0003011_delayed_dark_adaptation2.62303158
9MP0002009_preneoplasia2.25546558
10MP0003045_fibrosis2.24247682
11MP0010352_gastrointestinal_tract_polyps2.12270648
12MP0003787_abnormal_imprinting2.11493135
13MP0003763_abnormal_thymus_physiology2.09937962
14MP0005671_abnormal_response_to2.05057550
15MP0002166_altered_tumor_susceptibility2.03762033
16MP0003890_abnormal_embryonic-extraembry2.03354433
17MP0005195_abnormal_posterior_eye1.99802173
18MP0005174_abnormal_tail_pigmentation1.94469553
19MP0005310_abnormal_salivary_gland1.90330875
20MP0002229_neurodegeneration1.89152326
21MP0000015_abnormal_ear_pigmentation1.83360792
22MP0004885_abnormal_endolymph1.74200857
23MP0003866_abnormal_defecation1.73540145
24MP0008877_abnormal_DNA_methylation1.67705251
25MP0001790_abnormal_immune_system1.63554293
26MP0005387_immune_system_phenotype1.63554293
27MP0005391_vision/eye_phenotype1.63321540
28MP0002638_abnormal_pupillary_reflex1.61379168
29MP0002095_abnormal_skin_pigmentation1.56457061
30MP0003183_abnormal_peptide_metabolism1.56368517
31MP0005409_darkened_coat_color1.56225637
32MP0001800_abnormal_humoral_immune1.55276790
33MP0002006_tumorigenesis1.53995592
34MP0001324_abnormal_eye_pigmentation1.53964364
35MP0002090_abnormal_vision1.51386379
36MP0000465_gastrointestinal_hemorrhage1.44519563
37MP0000383_abnormal_hair_follicle1.42920010
38MP0005187_abnormal_penis_morphology1.40551338
39MP0004742_abnormal_vestibular_system1.39758831
40MP0005386_behavior/neurological_phenoty1.39510783
41MP0004924_abnormal_behavior1.39510783
42MP0000462_abnormal_digestive_system1.38864850
43MP0001873_stomach_inflammation1.38637822
44MP0010678_abnormal_skin_adnexa1.38318815
45MP0004043_abnormal_pH_regulation1.36572106
46MP0001851_eye_inflammation1.35891215
47MP0001486_abnormal_startle_reflex1.35541297
48MP0000647_abnormal_sebaceous_gland1.32647952
49MP0000685_abnormal_immune_system1.31945312
50MP0004147_increased_porphyrin_level1.31491192
51MP0003690_abnormal_glial_cell1.31371934
52MP0005423_abnormal_somatic_nervous1.29504694
53MP0003634_abnormal_glial_cell1.29025009
54MP0004264_abnormal_extraembryonic_tissu1.25505128
55MP0002723_abnormal_immune_serum1.24421202
56MP0002822_catalepsy1.24198586
57MP0003656_abnormal_erythrocyte_physiolo1.24126108
58MP0002420_abnormal_adaptive_immunity1.23917111
59MP0006054_spinal_hemorrhage1.22769587
60MP0001819_abnormal_immune_cell1.22339045
61MP0003252_abnormal_bile_duct1.22168535
62MP0003303_peritoneal_inflammation1.22042581
63MP0004270_analgesia1.21860012
64MP0004185_abnormal_adipocyte_glucose1.21200083
65MP0009697_abnormal_copulation1.20830441
66MP0002398_abnormal_bone_marrow1.19750992
67MP0000703_abnormal_thymus_morphology1.18795080
68MP0001502_abnormal_circadian_rhythm1.17275972
69MP0004381_abnormal_hair_follicle1.15746113
70MP0003943_abnormal_hepatobiliary_system1.13755638
71MP0001501_abnormal_sleep_pattern1.12915192
72MP0008569_lethality_at_weaning1.12799817
73MP0004484_altered_response_of1.12625859
74MP0002452_abnormal_antigen_presenting1.12625499
75MP0004510_myositis1.12164304
76MP0005248_abnormal_Harderian_gland1.11857844
77MP0002752_abnormal_somatic_nervous1.09219397
78MP0002882_abnormal_neuron_morphology1.08526654
79MP0005000_abnormal_immune_tolerance1.08386629
80MP0004947_skin_inflammation1.04827840
81MP0000003_abnormal_adipose_tissue1.04375597
82MP0000716_abnormal_immune_system1.03998448
83MP0003868_abnormal_feces_composition1.03683734
84MP0001986_abnormal_taste_sensitivity1.02522247
85MP0008961_abnormal_basal_metabolism1.02329875
86MP0001346_abnormal_lacrimal_gland1.02264855
87MP0003091_abnormal_cell_migration1.01408246
88MP0002928_abnormal_bile_duct0.99873359
89MP0003633_abnormal_nervous_system0.98280109
90MP0003121_genomic_imprinting0.97997350
91MP0001661_extended_life_span0.94720471
92MP0001984_abnormal_olfaction0.94603096
93MP0004808_abnormal_hematopoietic_stem0.94518322
94MP0005076_abnormal_cell_differentiation0.94438374
95MP0010155_abnormal_intestine_physiology0.93568983
96MP0000733_abnormal_muscle_development0.93140516
97MP0000778_abnormal_nervous_system0.92284248
98MP0009046_muscle_twitch0.91622610
99MP0002405_respiratory_system_inflammati0.90660177
100MP0010234_abnormal_vibrissa_follicle0.90555521
101MP0002272_abnormal_nervous_system0.89753924
102MP0002168_other_aberrant_phenotype0.89648556
103MP0005645_abnormal_hypothalamus_physiol0.87276164
104MP0009278_abnormal_bone_marrow0.86509757
105MP0000371_diluted_coat_color0.85986130
106MP0002751_abnormal_autonomic_nervous0.85557548
107MP0000377_abnormal_hair_follicle0.84778997
108MP0010307_abnormal_tumor_latency0.83038642
109MP0002722_abnormal_immune_system0.80421002
110MP0006276_abnormal_autonomic_nervous0.80087080
111MP0000631_abnormal_neuroendocrine_gland0.78070567
112MP0003724_increased_susceptibility_to0.77617815
113MP0003632_abnormal_nervous_system0.77337221
114MP0001299_abnormal_eye_distance/0.77268329
115MP0001835_abnormal_antigen_presentation0.76648773
116MP0000427_abnormal_hair_cycle0.75826995
117MP0005171_absent_coat_pigmentation0.74019691
118MP0003453_abnormal_keratinocyte_physiol0.72983135
119MP0000428_abnormal_craniofacial_morphol0.72754865
120MP0001485_abnormal_pinna_reflex0.71554096
121MP0001177_atelectasis0.70750842
122MP0005623_abnormal_meninges_morphology0.70375689
123MP0003828_pulmonary_edema0.70240706
124MP0002429_abnormal_blood_cell0.69839465
125MP0002933_joint_inflammation0.69407480
126MP0003221_abnormal_cardiomyocyte_apopto0.68785379
127MP0004142_abnormal_muscle_tone0.67520193
128MP0005075_abnormal_melanosome_morpholog0.67330784
129MP0002877_abnormal_melanocyte_morpholog0.66696250
130MP0009115_abnormal_fat_cell0.66207493
131MP0001784_abnormal_fluid_regulation0.66107218
132MP0005375_adipose_tissue_phenotype0.65392995
133MP0005025_abnormal_response_to0.64627947
134MP0000689_abnormal_spleen_morphology0.63813430
135MP0002063_abnormal_learning/memory/cond0.62893850
136MP0000538_abnormal_urinary_bladder0.62479099
137MP0009780_abnormal_chondrocyte_physiolo0.62408949
138MP0003880_abnormal_central_pattern0.61821481
139MP0004130_abnormal_muscle_cell0.61294762
140MP0002098_abnormal_vibrissa_morphology0.60601702
141MP0001879_abnormal_lymphatic_vessel0.60108436
142MP0004134_abnormal_chest_morphology0.57475452
143MP0002925_abnormal_cardiovascular_devel0.57230923
144MP0002396_abnormal_hematopoietic_system0.56177317
145MP0001191_abnormal_skin_condition0.55522075
146MP0002064_seizures0.54766542
147MP0003172_abnormal_lysosome_physiology0.54647798
148MP0003635_abnormal_synaptic_transmissio0.54568974
149MP0004811_abnormal_neuron_physiology0.54460707
150MP0002067_abnormal_sensory_capabilities0.54067306
151MP0008057_abnormal_DNA_replication0.53843644
152MP0003631_nervous_system_phenotype0.52337610
153MP0002419_abnormal_innate_immunity0.51442387
154MP0002148_abnormal_hypersensitivity_rea0.51225625

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.39324810
2Bony spicule pigmentary retinopathy (HP:0007737)5.64182776
3Dyschromatopsia (HP:0007641)5.03987058
4Central scotoma (HP:0000603)5.03580288
5Abnormal rod and cone electroretinograms (HP:0008323)4.53863888
6Abnormality of macular pigmentation (HP:0008002)4.53457576
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.27787335
8Pigmentary retinal degeneration (HP:0001146)4.22445995
9Abnormality of the fingertips (HP:0001211)4.11994545
10Scotoma (HP:0000575)4.03673527
11Papillary thyroid carcinoma (HP:0002895)3.72366006
12Abolished electroretinogram (ERG) (HP:0000550)3.46119366
13Hyperventilation (HP:0002883)3.37873110
14Decreased central vision (HP:0007663)3.36293894
15Attenuation of retinal blood vessels (HP:0007843)3.33529504
16Cone-rod dystrophy (HP:0000548)3.26257493
17Chorioretinal atrophy (HP:0000533)3.18189841
18Pendular nystagmus (HP:0012043)3.06635641
19Macroorchidism (HP:0000053)2.90100294
20Fair hair (HP:0002286)2.86873241
21Photophobia (HP:0000613)2.85250533
22T lymphocytopenia (HP:0005403)2.81021206
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.80559018
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80559018
25Macular degeneration (HP:0000608)2.78357844
26Type II diabetes mellitus (HP:0005978)2.77820285
27Drooling (HP:0002307)2.72074580
28Keratoconus (HP:0000563)2.67561986
29Increased corneal curvature (HP:0100692)2.67561986
30Protruding tongue (HP:0010808)2.64503627
31Acute myeloid leukemia (HP:0004808)2.63221400
32Excessive salivation (HP:0003781)2.60768126
33Abnormality of T cell number (HP:0011839)2.57101663
34Gaze-evoked nystagmus (HP:0000640)2.54967359
35Large earlobe (HP:0009748)2.54275264
36Choroideremia (HP:0001139)2.53376047
37Stomach cancer (HP:0012126)2.52176555
38Generalized hypopigmentation of hair (HP:0011358)2.47975880
39Sandal gap (HP:0001852)2.45983316
40Absent speech (HP:0001344)2.45073620
41Chronic hepatic failure (HP:0100626)2.43966574
42Thyroid carcinoma (HP:0002890)2.41143541
43Volvulus (HP:0002580)2.40271507
44Thyroiditis (HP:0100646)2.39686227
45Severe visual impairment (HP:0001141)2.34682951
46Onion bulb formation (HP:0003383)2.30135145
47Lip pit (HP:0100267)2.29315112
48Hip dysplasia (HP:0001385)2.28790591
49Curly hair (HP:0002212)2.27801230
50Hematochezia (HP:0002573)2.24378704
51Hypoplastic labia majora (HP:0000059)2.24261249
52Widely spaced teeth (HP:0000687)2.18066797
53Abnormality of the renal cortex (HP:0011035)2.17791871
54Progressive cerebellar ataxia (HP:0002073)2.16527579
55Oligodactyly (hands) (HP:0001180)2.15234855
56Abnormal biliary tract morphology (HP:0012440)2.10913354
57Anteriorly placed anus (HP:0001545)2.10648849
58Slow saccadic eye movements (HP:0000514)2.08513154
59Cystic hygroma (HP:0000476)2.05162638
60Retinitis pigmentosa (HP:0000510)2.05104372
61Abnormality of the corticospinal tract (HP:0002492)2.03454383
62Abnormality of the labia majora (HP:0012881)2.03193187
63Blue irides (HP:0000635)2.01432502
64Subacute progressive viral hepatitis (HP:0006572)2.00219097
65Agammaglobulinemia (HP:0004432)1.98044192
66Supranuclear gaze palsy (HP:0000605)1.97018193
67Hyperkalemia (HP:0002153)1.96981643
68Recurrent viral infections (HP:0004429)1.96421404
69Hypoplastic iliac wings (HP:0002866)1.95736616
70Vertebral arch anomaly (HP:0008438)1.95329759
71Metabolic alkalosis (HP:0200114)1.93360585
72Abnormal auditory evoked potentials (HP:0006958)1.91771342
73Short 4th metacarpal (HP:0010044)1.91046992
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91046992
75Biliary tract neoplasm (HP:0100574)1.90996532
76Severe combined immunodeficiency (HP:0004430)1.90728125
77Heterotopia (HP:0002282)1.89777823
78Congenital sensorineural hearing impairment (HP:0008527)1.88781710
79Constricted visual fields (HP:0001133)1.87786869
80Short chin (HP:0000331)1.86128591
81Absent frontal sinuses (HP:0002688)1.85599869
82Submucous cleft hard palate (HP:0000176)1.84623780
83Prominent nose (HP:0000448)1.84584963
84Broad-based gait (HP:0002136)1.83069025
85Abnormality of chromosome stability (HP:0003220)1.82660323
86Recurrent fungal infections (HP:0002841)1.81669780
87Abnormality of the renal medulla (HP:0100957)1.81383527
88Abnormality of salivation (HP:0100755)1.79146783
89Neoplasm of the tracheobronchial system (HP:0100552)1.78793644
90Aqueductal stenosis (HP:0002410)1.78173360
91Gastrointestinal stroma tumor (HP:0100723)1.77392313
92Pancreatic cysts (HP:0001737)1.77325168
93Retrobulbar optic neuritis (HP:0100654)1.77267557
94Optic neuritis (HP:0100653)1.77267557
95B lymphocytopenia (HP:0010976)1.76609046
96Abnormality of B cell number (HP:0010975)1.76609046
97Abnormal pancreas size (HP:0012094)1.76362549
98Premature skin wrinkling (HP:0100678)1.75576500
99Long clavicles (HP:0000890)1.75533926
100Tubulointerstitial nephritis (HP:0001970)1.75021420
101Urinary bladder sphincter dysfunction (HP:0002839)1.74687644
102Long eyelashes (HP:0000527)1.74570968
103Difficulty running (HP:0009046)1.74356598
104Progressive visual loss (HP:0000529)1.73758859
105Tented upper lip vermilion (HP:0010804)1.73666277
106Spontaneous hematomas (HP:0007420)1.73580483
107Genetic anticipation (HP:0003743)1.73494153
108Renal cortical cysts (HP:0000803)1.72639675
109Poor coordination (HP:0002370)1.71902520
110Periodontitis (HP:0000704)1.71731275
111Chronic diarrhea (HP:0002028)1.71731115
112Hepatoblastoma (HP:0002884)1.70678182
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70462587
114Sensory axonal neuropathy (HP:0003390)1.70461790
115Abnormality of the astrocytes (HP:0100707)1.70202476
116Astrocytoma (HP:0009592)1.70202476
117Panhypogammaglobulinemia (HP:0003139)1.69121965
118Bladder carcinoma (HP:0002862)1.68450996
119Bladder neoplasm (HP:0009725)1.68450996
120Spastic gait (HP:0002064)1.67991400
121Neurofibrillary tangles (HP:0002185)1.67896390
122Open mouth (HP:0000194)1.67683835
123Inflammation of the large intestine (HP:0002037)1.67583209
124Abnormality of chloride homeostasis (HP:0011422)1.67085512
125Lymphopenia (HP:0001888)1.66693550
126Decreased circulating renin level (HP:0003351)1.65976991
127Intestinal atresia (HP:0011100)1.65944662
128Hyporeflexia of lower limbs (HP:0002600)1.65706859
129Abnormality of secondary sexual hair (HP:0009888)1.65426605
130Abnormality of the axillary hair (HP:0100134)1.65426605
131Abnormality of incisor morphology (HP:0011063)1.65201048
132Low anterior hairline (HP:0000294)1.64854834
133Poikilocytosis (HP:0004447)1.64457635
134Medial flaring of the eyebrow (HP:0010747)1.64163795
135Abnormality of the ischium (HP:0003174)1.63572004
136Scanning speech (HP:0002168)1.63241540
137Exotropia (HP:0000577)1.63199026
138Mask-like facies (HP:0000298)1.62894827
139Narrow palate (HP:0000189)1.62414150
140Cupped ear (HP:0000378)1.60763647
141Medulloblastoma (HP:0002885)1.59792954
142Transitional cell carcinoma of the bladder (HP:0006740)1.59467419
143Autoimmune hemolytic anemia (HP:0001890)1.59400317
144Insidious onset (HP:0003587)1.59346569
145Termporal pattern (HP:0011008)1.59346569
146Overgrowth (HP:0001548)1.59215481
147Peripheral hypomyelination (HP:0007182)1.59045623
148Pancreatic fibrosis (HP:0100732)1.59036843
149Alacrima (HP:0000522)1.59035560
150Tapered finger (HP:0001182)1.58911764
151Colitis (HP:0002583)1.58319559
152Spastic paraplegia (HP:0001258)1.57844449
153Thick eyebrow (HP:0000574)1.57718774
154Acanthocytosis (HP:0001927)1.57659625
155Ureteral obstruction (HP:0006000)1.57611419
156Clubbing of toes (HP:0100760)1.57489830
157Chronic otitis media (HP:0000389)1.57308309
158Limited elbow extension (HP:0001377)1.56974874
159Depressed nasal tip (HP:0000437)1.56670958
160Ectropion (HP:0000656)1.56535920
161Decreased lacrimation (HP:0000633)1.55390734
162Abnormality of the nasal septum (HP:0000419)1.55155199
163Febrile seizures (HP:0002373)1.55109506
164Obsessive-compulsive behavior (HP:0000722)1.51218037
165Abnormal hair whorl (HP:0010721)1.51145891
166Decreased motor nerve conduction velocity (HP:0003431)1.50644701
167Chronic mucocutaneous candidiasis (HP:0002728)1.50192925
168Recurrent cutaneous fungal infections (HP:0011370)1.50192925
169Truncal obesity (HP:0001956)1.49878913
170Vasculitis (HP:0002633)1.49381132
171Truncal ataxia (HP:0002078)1.49376343
172Gastrointestinal inflammation (HP:0004386)1.49172680
173Posterior subcapsular cataract (HP:0007787)1.48095406
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.47998328
175Abnormality of eosinophils (HP:0001879)1.47954429
176Recurrent bronchitis (HP:0002837)1.46012038
177Prolonged QT interval (HP:0001657)1.45876965
178Ureteral stenosis (HP:0000071)1.45650705
179Abnormal delayed hypersensitivity skin test (HP:0002963)1.45198688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.00134240
2STK392.98027462
3EPHB12.81618931
4CDK122.61831409
5AKT32.60595141
6TXK2.40567780
7MAP3K42.23750365
8CASK2.22780998
9MAP4K12.13498095
10WNK12.03223129
11ITK1.98303914
12CAMK1G1.97948016
13PKN11.88158613
14FGFR21.87861829
15MAPK131.70945912
16PIK3CA1.70571461
17TAOK31.66842441
18GRK11.65490001
19BRD41.63089073
20JAK11.62446508
21MARK21.53190584
22NUAK11.51815280
23DMPK1.51018109
24HIPK21.50791404
25FGFR31.50001194
26ERBB31.45076933
27CAMK1D1.43884000
28CLK11.43339850
29STK101.42494143
30MAP3K101.36462438
31INSRR1.35672619
32CAMKK21.30272312
33PRKCH1.29563554
34MARK11.28144647
35TEC1.25686037
36EPHA31.25153429
37FES1.24919108
38LMTK21.23431705
39STK38L1.23414143
40YES11.22293478
41BMPR21.22204681
42CSNK1A1L1.17677997
43CDK91.17329180
44BMPR1B1.15752944
45SIK21.12047911
46MAP3K71.10720392
47MAP3K61.10362507
48PRKCQ1.10131739
49JAK31.09561964
50TYK21.09318950
51OXSR11.09269410
52MST41.08935715
53ICK1.07055248
54SGK2231.06205463
55SGK4941.06205463
56WNK41.06187236
57PDGFRB1.05366722
58PTK2B1.03505987
59BCR1.03213638
60IKBKE1.01945501
61STK40.98101123
62CSK0.97823923
63MAP3K20.96287647
64KSR10.93896775
65MAP3K130.93526718
66TRPM70.92607663
67HCK0.92016295
68NLK0.91042562
69MAP3K140.91014276
70SGK30.90915365
71LCK0.90211115
72FGFR40.86462572
73PRPF4B0.86271764
74NEK60.86240285
75PRKD20.85410760
76WNK30.84308901
77ROCK20.84003135
78MELK0.83849326
79EEF2K0.82434930
80CHUK0.80769523
81CDK60.80552711
82FRK0.80351695
83UHMK10.80070382
84LATS10.80065251
85TYRO30.79111137
86MET0.78380764
87PIK3CG0.77867084
88MAPK70.75060074
89IRAK20.73538962
90STK240.73343865
91CSNK1D0.72827088
92TNIK0.72331501
93PLK20.72287054
94MKNK20.71802513
95SYK0.71387446
96TNK20.71274221
97DYRK1A0.70998728
98SGK20.70262082
99BRSK20.70216240
100PRKD10.68178895
101CAMK40.67892198
102EPHA40.67856510
103FYN0.67785023
104CSNK1G10.67414333
105STK110.66583074
106FER0.66582571
107NEK90.66325647
108MAP2K40.65868561
109CDC42BPA0.64694509
110NTRK20.64095272
111CSNK1G20.63553319
112PNCK0.63372036
113MARK30.63078315
114SGK10.62730400
115MAPKAPK50.62318492
116CSNK1G30.62128492
117PRKAA20.61088758
118MAP2K70.61033637
119RPS6KA50.60092369
120MTOR0.59796618
121BLK0.58312772
122RET0.57622622
123PAK30.56186718
124BTK0.55952739
125IRAK10.55536491
126PBK0.55531178
127DYRK1B0.54659903
128PDK10.54580624
129ERBB20.54498624
130NTRK30.53620708
131STK30.51368461
132PAK60.51164525
133STK380.50940757
134PRKAA10.48819856
135PKN20.48815902
136CDK50.47603305
137JAK20.47557669
138IKBKB0.47054151
139GRK60.46434407
140PRKCE0.46340954
141RPS6KB10.43045043
142TGFBR10.42898420
143FGFR10.42729957
144EGFR0.42690850

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.28729483
2Primary immunodeficiency_Homo sapiens_hsa053401.88302003
3T cell receptor signaling pathway_Homo sapiens_hsa046601.58218183
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47945960
5B cell receptor signaling pathway_Homo sapiens_hsa046621.40269259
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38857950
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29413626
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29064892
9Dorso-ventral axis formation_Homo sapiens_hsa043201.26709391
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21496106
11Nitrogen metabolism_Homo sapiens_hsa009101.17290033
12Prolactin signaling pathway_Homo sapiens_hsa049171.16960380
13Chemokine signaling pathway_Homo sapiens_hsa040621.16219488
14Axon guidance_Homo sapiens_hsa043601.15268220
15Nicotine addiction_Homo sapiens_hsa050331.15265251
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.13335071
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13312651
18Type II diabetes mellitus_Homo sapiens_hsa049301.12672695
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10227883
20Osteoclast differentiation_Homo sapiens_hsa043801.10110463
21Renal cell carcinoma_Homo sapiens_hsa052111.08899181
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.06096420
23Alcoholism_Homo sapiens_hsa050341.05280410
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.03668157
25Inositol phosphate metabolism_Homo sapiens_hsa005621.02657927
26Long-term potentiation_Homo sapiens_hsa047201.02611743
27Cholinergic synapse_Homo sapiens_hsa047251.02387449
28Taste transduction_Homo sapiens_hsa047421.02222793
29Choline metabolism in cancer_Homo sapiens_hsa052311.01361463
30Leukocyte transendothelial migration_Homo sapiens_hsa046700.99925571
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99688942
32Morphine addiction_Homo sapiens_hsa050320.99122917
33Chronic myeloid leukemia_Homo sapiens_hsa052200.98607440
34Systemic lupus erythematosus_Homo sapiens_hsa053220.96015673
35Pancreatic cancer_Homo sapiens_hsa052120.95175812
36Viral myocarditis_Homo sapiens_hsa054160.95153199
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94338435
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94139584
39Measles_Homo sapiens_hsa051620.93335683
40Salivary secretion_Homo sapiens_hsa049700.92312103
41Olfactory transduction_Homo sapiens_hsa047400.92070814
42Hematopoietic cell lineage_Homo sapiens_hsa046400.91161499
43ErbB signaling pathway_Homo sapiens_hsa040120.91043209
44Platelet activation_Homo sapiens_hsa046110.90708212
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90598721
46Glutamatergic synapse_Homo sapiens_hsa047240.90578234
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.90494490
48Dilated cardiomyopathy_Homo sapiens_hsa054140.90382260
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90153894
50Renin secretion_Homo sapiens_hsa049240.88663482
51Toxoplasmosis_Homo sapiens_hsa051450.88174680
52Caffeine metabolism_Homo sapiens_hsa002320.88164228
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87918929
54Serotonergic synapse_Homo sapiens_hsa047260.86660562
55Gastric acid secretion_Homo sapiens_hsa049710.86006574
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85589283
57MAPK signaling pathway_Homo sapiens_hsa040100.85286580
58Lysine degradation_Homo sapiens_hsa003100.83719221
59GABAergic synapse_Homo sapiens_hsa047270.83283698
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80804352
61Oxytocin signaling pathway_Homo sapiens_hsa049210.80615667
62Endocytosis_Homo sapiens_hsa041440.79803843
63Insulin secretion_Homo sapiens_hsa049110.79214303
64Ether lipid metabolism_Homo sapiens_hsa005650.78909083
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78850083
66Non-small cell lung cancer_Homo sapiens_hsa052230.78805334
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78617894
68Circadian entrainment_Homo sapiens_hsa047130.78214799
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.77870773
70Pancreatic secretion_Homo sapiens_hsa049720.77566343
71cAMP signaling pathway_Homo sapiens_hsa040240.77204809
72mTOR signaling pathway_Homo sapiens_hsa041500.77118182
73Prostate cancer_Homo sapiens_hsa052150.76711164
74MicroRNAs in cancer_Homo sapiens_hsa052060.76485312
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.75982497
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75961764
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75184137
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75046297
79Amphetamine addiction_Homo sapiens_hsa050310.74909194
80Acute myeloid leukemia_Homo sapiens_hsa052210.74786699
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74291569
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.73807747
83Notch signaling pathway_Homo sapiens_hsa043300.72786820
84Small cell lung cancer_Homo sapiens_hsa052220.72770615
85ABC transporters_Homo sapiens_hsa020100.72580243
86Dopaminergic synapse_Homo sapiens_hsa047280.72288138
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72011574
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71933916
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71780336
90Circadian rhythm_Homo sapiens_hsa047100.71299434
91Endometrial cancer_Homo sapiens_hsa052130.70567239
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70230686
93Linoleic acid metabolism_Homo sapiens_hsa005910.70225396
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70032455
95Focal adhesion_Homo sapiens_hsa045100.70013072
96Autoimmune thyroid disease_Homo sapiens_hsa053200.69803295
97Graft-versus-host disease_Homo sapiens_hsa053320.69235975
98Colorectal cancer_Homo sapiens_hsa052100.67999518
99Mineral absorption_Homo sapiens_hsa049780.67199302
100Hepatitis B_Homo sapiens_hsa051610.67068086
101Fanconi anemia pathway_Homo sapiens_hsa034600.67025579
102Glioma_Homo sapiens_hsa052140.66871943
103Adherens junction_Homo sapiens_hsa045200.66565846
104Ras signaling pathway_Homo sapiens_hsa040140.66530997
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65884336
106Leishmaniasis_Homo sapiens_hsa051400.65788831
107ECM-receptor interaction_Homo sapiens_hsa045120.65498563
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65016445
109VEGF signaling pathway_Homo sapiens_hsa043700.64528620
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63315329
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62897477
112Sphingolipid metabolism_Homo sapiens_hsa006000.62474718
113Long-term depression_Homo sapiens_hsa047300.62001241
114Gap junction_Homo sapiens_hsa045400.61033831
115GnRH signaling pathway_Homo sapiens_hsa049120.60851743
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60497893
117FoxO signaling pathway_Homo sapiens_hsa040680.59419866
118Allograft rejection_Homo sapiens_hsa053300.59333893
119Tight junction_Homo sapiens_hsa045300.59066158
120Calcium signaling pathway_Homo sapiens_hsa040200.58599672
121Estrogen signaling pathway_Homo sapiens_hsa049150.58583469
122Viral carcinogenesis_Homo sapiens_hsa052030.58212619
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57399033
124Rap1 signaling pathway_Homo sapiens_hsa040150.57175240
125Non-homologous end-joining_Homo sapiens_hsa034500.54822393
126Pathways in cancer_Homo sapiens_hsa052000.53999350

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