FRZB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.94093910
2endocrine pancreas development (GO:0031018)6.93192952
3protein maturation by protein folding (GO:0022417)6.72952095
4COPII vesicle coating (GO:0048208)6.26970360
5protein retention in ER lumen (GO:0006621)6.17265926
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.02854899
7peptide hormone processing (GO:0016486)5.94320446
8type B pancreatic cell development (GO:0003323)5.76635109
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.70467384
10regulation of type B pancreatic cell apoptotic process (GO:2000674)5.66497848
11signal peptide processing (GO:0006465)5.17560286
12exocrine pancreas development (GO:0031017)5.17073998
13glandular epithelial cell differentiation (GO:0002067)5.16374271
14glandular epithelial cell development (GO:0002068)5.11856958
15positive regulation of calcium ion import (GO:0090280)5.10016872
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.05835606
17positive regulation of nuclease activity (GO:0032075)4.79615473
18regulation of axon guidance (GO:1902667)4.74448492
19vesicle coating (GO:0006901)4.67036551
20insulin secretion (GO:0030073)4.65640558
21germ cell migration (GO:0008354)4.65130145
22short-term memory (GO:0007614)4.55258486
23regulation of non-canonical Wnt signaling pathway (GO:2000050)4.50881009
24positive regulation of catecholamine secretion (GO:0033605)4.44410678
25ER overload response (GO:0006983)4.44225524
26cellular response to vitamin D (GO:0071305)4.43404366
27sequestering of metal ion (GO:0051238)4.40695138
28positive regulation of insulin secretion (GO:0032024)4.40360928
29regulation of nuclease activity (GO:0032069)4.33650652
30detection of calcium ion (GO:0005513)4.28075810
31regulation of axon extension involved in axon guidance (GO:0048841)4.20816853
32vitamin A metabolic process (GO:0006776)4.20189668
33regulation of insulin secretion (GO:0050796)4.17683077
34endoplasmic reticulum unfolded protein response (GO:0030968)4.16316895
35locomotory exploration behavior (GO:0035641)4.08945155
36nitric oxide mediated signal transduction (GO:0007263)4.08416827
37cellular response to unfolded protein (GO:0034620)4.06054952
38regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.04941407
39negative regulation of norepinephrine secretion (GO:0010700)4.02074351
40ER-nucleus signaling pathway (GO:0006984)3.92358462
41cellular response to topologically incorrect protein (GO:0035967)3.91128984
42otic vesicle formation (GO:0030916)3.91063594
43columnar/cuboidal epithelial cell development (GO:0002066)3.82030893
44regulation of peptide hormone secretion (GO:0090276)3.78470956
45negative regulation of insulin secretion (GO:0046676)3.76474325
46ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.75019678
47regulation of peptide secretion (GO:0002791)3.72323944
48head development (GO:0060322)3.71663522
49parturition (GO:0007567)3.69870046
50negative regulation of glycoprotein biosynthetic process (GO:0010561)3.69689147
51glucocorticoid biosynthetic process (GO:0006704)3.69034947
52phenylpropanoid metabolic process (GO:0009698)3.66150437
53epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.63490770
54intra-Golgi vesicle-mediated transport (GO:0006891)3.63028679
55peptide hormone secretion (GO:0030072)3.58067474
56axon extension involved in axon guidance (GO:0048846)3.57714797
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.57714797
58positive regulation of odontogenesis (GO:0042482)3.56311333
59regulation of calcium ion import (GO:0090279)3.55187195
60protein N-linked glycosylation via asparagine (GO:0018279)3.54594842
61negative regulation of catecholamine secretion (GO:0033604)3.54061780
62glomerulus development (GO:0032835)3.53515988
63synaptic transmission, dopaminergic (GO:0001963)3.53077195
64peptidyl-asparagine modification (GO:0018196)3.52979065
65ER to Golgi vesicle-mediated transport (GO:0006888)3.50906198
66peptide secretion (GO:0002790)3.50087412
67positive regulation of peptide hormone secretion (GO:0090277)3.49792996
68tooth mineralization (GO:0034505)3.48636744
69toxin metabolic process (GO:0009404)3.47214737
70response to endoplasmic reticulum stress (GO:0034976)3.42639706
71positive regulation of peptide secretion (GO:0002793)3.41282852
72protein localization to Golgi apparatus (GO:0034067)3.40210771
73cell migration involved in heart development (GO:0060973)3.39921122
74regulation of hormone secretion (GO:0046883)3.32527712
75paraxial mesoderm development (GO:0048339)3.32275765
76adrenal gland development (GO:0030325)3.29420334
77peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28620253
78epithelial cell fate commitment (GO:0072148)3.25785370
79positive regulation of digestive system process (GO:0060456)3.24540119
80protein N-linked glycosylation (GO:0006487)3.24410144
81negative regulation of peptide hormone secretion (GO:0090278)3.24386306
82response to unfolded protein (GO:0006986)3.23987066
83negative regulation of axon guidance (GO:1902668)3.23793605
84regulation of gonadotropin secretion (GO:0032276)3.22333141
85inner ear receptor cell development (GO:0060119)3.21634184
86induction of positive chemotaxis (GO:0050930)3.19242745
87retinal ganglion cell axon guidance (GO:0031290)3.17619152
88cellular zinc ion homeostasis (GO:0006882)3.15879692
89gamma-aminobutyric acid transport (GO:0015812)3.13220579
90response to topologically incorrect protein (GO:0035966)3.12548270
91signal transduction involved in regulation of gene expression (GO:0023019)3.10796241
92negative regulation of peptide secretion (GO:0002792)3.10707900
93regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.06746534
94endocardial cushion morphogenesis (GO:0003203)3.04406117
95presynaptic membrane assembly (GO:0097105)3.03138335
96regulation of peptide transport (GO:0090087)3.03100234
97response to hexose (GO:0009746)3.02845086
984-hydroxyproline metabolic process (GO:0019471)3.01999755
99cellular response to vitamin (GO:0071295)3.01991647
100response to glucose (GO:0009749)3.00305075
101astrocyte differentiation (GO:0048708)2.99445211
102regulation of glucocorticoid secretion (GO:2000849)2.98914163
103positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.97803221
104negative regulation of circadian rhythm (GO:0042754)2.97536292
105hypothalamus development (GO:0021854)2.96387830
106Golgi organization (GO:0007030)2.95569645
107regulation of energy homeostasis (GO:2000505)2.93676070
108notochord development (GO:0030903)2.93168787
109positive regulation of hormone secretion (GO:0046887)2.92333356
110response to monosaccharide (GO:0034284)2.91910190
111mesenchymal cell development (GO:0014031)2.89351862
112nonmotile primary cilium assembly (GO:0035058)2.87710697
113positive regulation of steroid hormone secretion (GO:2000833)2.87041860
114negative regulation of glycoprotein metabolic process (GO:1903019)2.84158058
115growth hormone secretion (GO:0030252)2.83776871
116regulation of corticosteroid hormone secretion (GO:2000846)2.83153075
117regulation of Golgi to plasma membrane protein transport (GO:0042996)2.82967894
118positive regulation of hormone biosynthetic process (GO:0046886)2.80722132
119negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80620547
120protein targeting to Golgi (GO:0000042)2.80527056
121cellular response to hepatocyte growth factor stimulus (GO:0035729)2.79397148
122response to hepatocyte growth factor (GO:0035728)2.79397148
123cerebellar Purkinje cell layer development (GO:0021680)2.79009597
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78641417
125hormone secretion (GO:0046879)2.77976506
126macroautophagy (GO:0016236)2.77596950
127regulation of appetite (GO:0032098)2.77356906
128pancreas development (GO:0031016)2.75399513
129cellular response to glucagon stimulus (GO:0071377)2.74870550
130neuron fate determination (GO:0048664)2.74376609
131neural crest cell development (GO:0014032)2.73908866
132Golgi vesicle transport (GO:0048193)2.72083664
133peptide transport (GO:0015833)2.71663818
134chemosensory behavior (GO:0007635)2.70949247
135chondrocyte development (GO:0002063)2.70121684
136positive regulation of glycolytic process (GO:0045821)2.68968322
137digestive tract morphogenesis (GO:0048546)2.68855686
138glucose homeostasis (GO:0042593)2.68366459
139carbohydrate homeostasis (GO:0033500)2.68366459
140behavioral response to ethanol (GO:0048149)2.66308477
141pharyngeal system development (GO:0060037)2.65207169
142neurotransmitter catabolic process (GO:0042135)2.65206589
143hormone transport (GO:0009914)2.62777231
144positive regulation of amine transport (GO:0051954)2.62734777
145nucleotide-sugar biosynthetic process (GO:0009226)2.62170321
146L-alpha-amino acid transmembrane transport (GO:1902475)2.61897906
147negative regulation of glycogen biosynthetic process (GO:0045719)2.61634449
148limb bud formation (GO:0060174)2.61598450
149postsynaptic membrane organization (GO:0001941)2.61298760
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60506709
151neuronal stem cell maintenance (GO:0097150)2.60368742
152outer ear morphogenesis (GO:0042473)2.58377812
153positive regulation of monocyte chemotaxis (GO:0090026)2.57327033
154exploration behavior (GO:0035640)2.56433847
155regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.55915568
156cGMP-mediated signaling (GO:0019934)2.55888897
157negative regulation of vascular permeability (GO:0043116)2.55865017
158G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55560699
159presynaptic membrane organization (GO:0097090)2.55416715
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51018075
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.51018075
162regulation of translation, ncRNA-mediated (GO:0045974)2.51018075
163negative chemotaxis (GO:0050919)2.50053589
164cellular response to electrical stimulus (GO:0071257)2.49530614
165regulation of monocyte chemotaxis (GO:0090025)2.49365863
166negative regulation of leukocyte migration (GO:0002686)2.49142693
167spinal cord development (GO:0021510)2.49002423
168cGMP biosynthetic process (GO:0006182)2.48626081
169cardiac epithelial to mesenchymal transition (GO:0060317)2.46629105
170regulation of dopamine secretion (GO:0014059)2.46273967
171* vasculature development (GO:0001944)2.45853575
172mesenchyme morphogenesis (GO:0072132)2.45751179
173radial glial cell differentiation (GO:0060019)2.44853030
174axonal fasciculation (GO:0007413)2.44795242
175* somite development (GO:0061053)2.40484982
176motor neuron axon guidance (GO:0008045)2.40221311
177somite rostral/caudal axis specification (GO:0032525)2.38106216
178calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37681678
179negative regulation of epidermis development (GO:0045683)2.36364986
180regulation of gastrulation (GO:0010470)2.35245435
181detection of light stimulus involved in visual perception (GO:0050908)2.33387709
182detection of light stimulus involved in sensory perception (GO:0050962)2.33387709
183neuron recognition (GO:0008038)2.31916633
184positive regulation of catenin import into nucleus (GO:0035413)2.31122730
185response to BMP (GO:0071772)2.30750711
186cellular response to BMP stimulus (GO:0071773)2.30750711
187triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.30236015
188kidney mesenchyme development (GO:0072074)2.29339523
189circadian sleep/wake cycle process (GO:0022410)2.28751238
190regulation of norepinephrine secretion (GO:0014061)2.28439669
191regulation of catecholamine secretion (GO:0050433)2.26370522
192nephron epithelium morphogenesis (GO:0072088)2.26332479
193nephron tubule morphogenesis (GO:0072078)2.26332479
194regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.26033607
195COPI coating of Golgi vesicle (GO:0048205)10.1165376
196Golgi transport vesicle coating (GO:0048200)10.1165376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.90438649
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.94397659
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53626479
4GATA1_22025678_ChIP-Seq_K562_Human2.41552316
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.34223228
6EZH2_22144423_ChIP-Seq_EOC_Human2.32050542
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.29104951
8* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08992686
9* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04762444
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03974602
11NR3C1_23031785_ChIP-Seq_PC12_Mouse2.03523125
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95096248
13POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94463250
14* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85998308
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82346967
16GBX2_23144817_ChIP-Seq_PC3_Human1.77313811
17TAF15_26573619_Chip-Seq_HEK293_Human1.75794242
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74767333
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74444787
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72483724
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72466530
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.72309820
23* EZH2_27304074_Chip-Seq_ESCs_Mouse1.71418580
24ZNF274_21170338_ChIP-Seq_K562_Hela1.69921736
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67545316
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63382678
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62322043
28IGF1R_20145208_ChIP-Seq_DFB_Human1.61701198
29* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58544933
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57369665
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57369665
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57369665
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.56422642
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56403054
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56331914
36REST_21632747_ChIP-Seq_MESCs_Mouse1.55841114
37* EED_16625203_ChIP-ChIP_MESCs_Mouse1.54454199
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51717082
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50650402
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50528024
41RNF2_27304074_Chip-Seq_NSC_Mouse1.50459537
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50094993
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48799849
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48780654
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.48056962
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.47652373
47TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43685168
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43059968
49FUS_26573619_Chip-Seq_HEK293_Human1.42789965
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.39163979
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37928655
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.37385258
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37127996
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37127996
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36795175
56BCAT_22108803_ChIP-Seq_LS180_Human1.35807130
57* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34500703
58* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33264813
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.32739316
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32373072
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32372553
62CLOCK_20551151_ChIP-Seq_293T_Human1.31820780
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.31761710
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.31414220
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29409973
66* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29361815
67* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29361815
68STAT3_23295773_ChIP-Seq_U87_Human1.29350750
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28912811
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28674121
71EWS_26573619_Chip-Seq_HEK293_Human1.28161694
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28144199
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26386776
74AR_25329375_ChIP-Seq_VCAP_Human1.25841739
75SMAD4_21799915_ChIP-Seq_A2780_Human1.25696433
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25650629
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25083746
78* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25062807
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24269362
80* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23653254
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23075783
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22825895
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22599578
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19190782
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.19152300
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18956339
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18563005
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18091110
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18034380
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16590941
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16333074
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.16029035
93* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15737554
94* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15545314
95* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.15253909
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14651499
97VDR_22108803_ChIP-Seq_LS180_Human1.14598783
98* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14546769
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.14341982
100* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14160338
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12283308
102AR_21572438_ChIP-Seq_LNCaP_Human1.11966408
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11763034
104* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10116474
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08586055
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.07748905
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06576511
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06269793
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05875914
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.04826682
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04053377
112DROSHA_22980978_ChIP-Seq_HELA_Human1.03221437
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02819539
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02492497
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02021553
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01183763
117RXR_22108803_ChIP-Seq_LS180_Human1.00999939
118AR_19668381_ChIP-Seq_PC3_Human1.00960361
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00855230
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00782048
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00705363
122NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00109369
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99995474
124* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99515851
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99072437
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99072437
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98942995
128GF1B_26923725_Chip-Seq_HPCs_Mouse0.96378686
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95563799
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.95124017
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93479539
132* RARB_27405468_Chip-Seq_BRAIN_Mouse0.91902249
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.91793606
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91200040
135* ISL1_27105846_Chip-Seq_CPCs_Mouse0.90707392
136P300_19829295_ChIP-Seq_ESCs_Human0.90592617
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88759302
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88146359
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.88057972
140TCF4_23295773_ChIP-Seq_U87_Human0.87587078
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87094546
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86526990
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.85764170
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85631862
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.85601160
146RUNX2_22187159_ChIP-Seq_PCA_Human0.85197501
147* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83942300
148MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83005385
149TCF4_22108803_ChIP-Seq_LS180_Human0.81977365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.09290163
2MP0003011_delayed_dark_adaptation4.72448424
3MP0009780_abnormal_chondrocyte_physiolo4.56509855
4MP0002877_abnormal_melanocyte_morpholog4.45808759
5MP0004043_abnormal_pH_regulation4.10317383
6MP0010030_abnormal_orbit_morphology3.95704754
7MP0002693_abnormal_pancreas_physiology3.68066354
8MP0003195_calcinosis3.60390687
9MP0002909_abnormal_adrenal_gland3.57911626
10MP0000678_abnormal_parathyroid_gland3.49380784
11MP0001944_abnormal_pancreas_morphology3.45980326
12MP0000013_abnormal_adipose_tissue3.31866431
13MP0010386_abnormal_urinary_bladder3.11519892
14MP0005379_endocrine/exocrine_gland_phen3.03101908
15MP0003136_yellow_coat_color2.93010080
16MP0006292_abnormal_olfactory_placode2.85530958
17MP0002938_white_spotting2.55068875
18MP0002837_dystrophic_cardiac_calcinosis2.53250888
19MP0003183_abnormal_peptide_metabolism2.43720051
20MP0005220_abnormal_exocrine_pancreas2.41828168
21MP0000372_irregular_coat_pigmentation2.24210899
22MP0006072_abnormal_retinal_apoptosis2.12682141
23MP0002896_abnormal_bone_mineralization2.08422263
24MP0002928_abnormal_bile_duct2.04458066
25MP0000537_abnormal_urethra_morphology2.03916302
26MP0003880_abnormal_central_pattern1.97242026
27MP0002138_abnormal_hepatobiliary_system1.96549270
28MP0002234_abnormal_pharynx_morphology1.93396986
29MP0002078_abnormal_glucose_homeostasis1.89646954
30MP0002822_catalepsy1.89646545
31MP0003122_maternal_imprinting1.89141019
32MP0009278_abnormal_bone_marrow1.88089507
33MP0005423_abnormal_somatic_nervous1.86788430
34MP0005646_abnormal_pituitary_gland1.85552234
35MP0005551_abnormal_eye_electrophysiolog1.76805905
36MP0000566_synostosis1.71285366
37MP0001293_anophthalmia1.69857444
38MP0000462_abnormal_digestive_system1.69809685
39MP0000613_abnormal_salivary_gland1.69257447
40MP0000003_abnormal_adipose_tissue1.66311789
41MP0000778_abnormal_nervous_system1.60782817
42MP0001984_abnormal_olfaction1.59089326
43MP0002233_abnormal_nose_morphology1.58651871
44MP0001270_distended_abdomen1.58602387
45MP0003119_abnormal_digestive_system1.53856714
46MP0003938_abnormal_ear_development1.53710140
47MP0003252_abnormal_bile_duct1.53658111
48MP0002697_abnormal_eye_size1.53482641
49MP0001299_abnormal_eye_distance/1.50153723
50MP0006276_abnormal_autonomic_nervous1.47086558
51MP0000647_abnormal_sebaceous_gland1.45595500
52MP0003567_abnormal_fetal_cardiomyocyte1.44192884
53MP0009379_abnormal_foot_pigmentation1.43801750
54MP0001286_abnormal_eye_development1.42522142
55MP0001765_abnormal_ion_homeostasis1.42403631
56MP0004264_abnormal_extraembryonic_tissu1.41201644
57MP0003329_amyloid_beta_deposits1.41049382
58MP0001324_abnormal_eye_pigmentation1.38998945
59MP0008789_abnormal_olfactory_epithelium1.38314419
60MP0000163_abnormal_cartilage_morphology1.37456541
61MP0001879_abnormal_lymphatic_vessel1.37271292
62MP0005503_abnormal_tendon_morphology1.36864261
63MP0004147_increased_porphyrin_level1.35737448
64MP0003937_abnormal_limbs/digits/tail_de1.33326270
65MP0005391_vision/eye_phenotype1.32264776
66MP0005394_taste/olfaction_phenotype1.30486958
67MP0005499_abnormal_olfactory_system1.30486958
68MP0000631_abnormal_neuroendocrine_gland1.29408369
69MP0002249_abnormal_larynx_morphology1.26649750
70MP0006054_spinal_hemorrhage1.25373105
71MP0002653_abnormal_ependyma_morphology1.25217628
72MP0005377_hearing/vestibular/ear_phenot1.24313052
73MP0003878_abnormal_ear_physiology1.24313052
74MP0002638_abnormal_pupillary_reflex1.22391800
75MP0008961_abnormal_basal_metabolism1.21542244
76MP0002163_abnormal_gland_morphology1.17390233
77MP0004270_analgesia1.16089281
78MP0002127_abnormal_cardiovascular_syste1.14395179
79MP0003172_abnormal_lysosome_physiology1.14215389
80MP0005645_abnormal_hypothalamus_physiol1.14209888
81MP0003953_abnormal_hormone_level1.14207269
82MP0001348_abnormal_lacrimal_gland1.13839701
83MP0001529_abnormal_vocalization1.11492233
84MP0003890_abnormal_embryonic-extraembry1.10987471
85MP0005257_abnormal_intraocular_pressure1.09079743
86MP0004019_abnormal_vitamin_homeostasis1.07502576
87MP0000751_myopathy1.07100099
88MP0000026_abnormal_inner_ear1.06598557
89MP0005195_abnormal_posterior_eye1.04764817
90MP0003300_gastrointestinal_ulcer1.04722391
91MP0002092_abnormal_eye_morphology1.03626080
92MP0005275_abnormal_skin_tensile1.03552785
93MP0005367_renal/urinary_system_phenotyp1.02415310
94MP0000516_abnormal_urinary_system1.02415310
95MP0001986_abnormal_taste_sensitivity1.02074148
96MP0003121_genomic_imprinting1.01601965
97MP0001485_abnormal_pinna_reflex1.00593111
98MP0003385_abnormal_body_wall1.00104392
99MP0009643_abnormal_urine_homeostasis1.00026777
100MP0005248_abnormal_Harderian_gland0.99922690
101MP0003755_abnormal_palate_morphology0.98778905
102MP0005187_abnormal_penis_morphology0.97102112
103MP0003879_abnormal_hair_cell0.95747097
104MP0003942_abnormal_urinary_system0.94697351
105MP0005171_absent_coat_pigmentation0.94432356
106MP0003868_abnormal_feces_composition0.93796699
107MP0000538_abnormal_urinary_bladder0.92510071
108MP0000049_abnormal_middle_ear0.91556442
109MP0002115_abnormal_skeleton_extremities0.91307024
110MP0002111_abnormal_tail_morphology0.90970214
111MP0005620_abnormal_muscle_contractility0.90903017
112MP0004145_abnormal_muscle_electrophysio0.90084109
113MP0000428_abnormal_craniofacial_morphol0.89591926
114MP0002009_preneoplasia0.89066519
115MP0000762_abnormal_tongue_morphology0.88925519
116MP0002876_abnormal_thyroid_physiology0.87253907
117MP0002752_abnormal_somatic_nervous0.86236998
118MP0003279_aneurysm0.86178846
119MP0005535_abnormal_body_temperature0.85723436
120MP0001919_abnormal_reproductive_system0.85601920
121MP0000681_abnormal_thyroid_gland0.83598567
122MP0004142_abnormal_muscle_tone0.83467907
123MP0002116_abnormal_craniofacial_bone0.81525873
124MP0005058_abnormal_lysosome_morphology0.81094210
125MP0005508_abnormal_skeleton_morphology0.79434305
126MP0003861_abnormal_nervous_system0.78940451
127MP0000432_abnormal_head_morphology0.78831098
128MP0002177_abnormal_outer_ear0.77925536
129MP0002557_abnormal_social/conspecific_i0.77311811
130MP0003795_abnormal_bone_structure0.76600996
131MP0005636_abnormal_mineral_homeostasis0.74792251
132MP0005369_muscle_phenotype0.74776475
133MP0003123_paternal_imprinting0.74521153
134MP0009384_cardiac_valve_regurgitation0.73221232
135MP0000639_abnormal_adrenal_gland0.72799628
136MP0008775_abnormal_heart_ventricle0.72699576
137MP0000230_abnormal_systemic_arterial0.72644766
138MP0004134_abnormal_chest_morphology0.71599039
139MP0005595_abnormal_vascular_smooth0.71581121
140MP0005375_adipose_tissue_phenotype0.71415376
141MP0002295_abnormal_pulmonary_circulatio0.70956950
142MP0002108_abnormal_muscle_morphology0.69815435
143MP0003935_abnormal_craniofacial_develop0.69714762
144MP0009250_abnormal_appendicular_skeleto0.69087179
145MP0004272_abnormal_basement_membrane0.68969590
146MP0004742_abnormal_vestibular_system0.68166461
147MP0001756_abnormal_urination0.66104062
148MP0003959_abnormal_lean_body0.64114705
149MP0001502_abnormal_circadian_rhythm0.63659168
150MP0000534_abnormal_ureter_morphology0.63364275
151MP0002933_joint_inflammation0.63200811
152MP0010368_abnormal_lymphatic_system0.62261576
153MP0005253_abnormal_eye_physiology0.61585939
154MP0005448_abnormal_energy_balance0.60922784
155MP0008438_abnormal_cutaneous_collagen0.60515681
156MP0002089_abnormal_postnatal_growth/wei0.58928781
157MP0004036_abnormal_muscle_relaxation0.56838104
158MP0004133_heterotaxia0.56502825
159MP0000955_abnormal_spinal_cord0.56209121
160MP0009672_abnormal_birth_weight0.56077576
161MP0004858_abnormal_nervous_system0.56057924
162MP0005310_abnormal_salivary_gland0.54579251
163MP0002113_abnormal_skeleton_development0.54099237
164MP0002734_abnormal_mechanical_nocicepti0.53386898
165MP0001346_abnormal_lacrimal_gland0.53224884
166MP0002109_abnormal_limb_morphology0.52488241
167MP0009703_decreased_birth_body0.51552144

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.67177841
2Hypoglycemic seizures (HP:0002173)7.07157744
3Symptomatic seizures (HP:0011145)6.63800407
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.11041890
5Hypoglycemic coma (HP:0001325)6.01231532
6Abnormal pancreas size (HP:0012094)4.62298274
7Insulin-resistant diabetes mellitus (HP:0000831)4.49899520
8Hyperglycemia (HP:0003074)4.39535702
9Ketoacidosis (HP:0001993)4.37190926
10Abnormality of the pancreatic islet cells (HP:0006476)4.27691106
11Abnormality of endocrine pancreas physiology (HP:0012093)4.27691106
12Abnormality of calcium-phosphate metabolism (HP:0100530)4.16640921
13Pancreatic islet-cell hyperplasia (HP:0004510)4.04577615
14Septo-optic dysplasia (HP:0100842)3.98071363
15Late onset (HP:0003584)3.79225240
16Large for gestational age (HP:0001520)3.78196856
17Epiphyseal dysplasia (HP:0002656)3.67391872
18Decreased circulating renin level (HP:0003351)3.60748716
19Generalized aminoaciduria (HP:0002909)3.59335250
20Polyphagia (HP:0002591)3.33488783
21Hypokalemia (HP:0002900)3.33315540
22Mucopolysacchariduria (HP:0008155)3.27189049
23Urinary glycosaminoglycan excretion (HP:0003541)3.27189049
24Preaxial foot polydactyly (HP:0001841)3.22757147
25Anophthalmia (HP:0000528)3.18354786
26Osteomalacia (HP:0002749)3.13118509
27Thoracolumbar scoliosis (HP:0002944)3.08852157
28Dysostosis multiplex (HP:0000943)3.02401586
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01627567
30Abnormality of polysaccharide metabolism (HP:0011012)3.01627567
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01627567
32Delayed epiphyseal ossification (HP:0002663)2.97245762
33Congenital stationary night blindness (HP:0007642)2.94784747
34Short hallux (HP:0010109)2.90004831
35Growth hormone deficiency (HP:0000824)2.86707190
36Protuberant abdomen (HP:0001538)2.84822339
37Aplasia/Hypoplasia of the hallux (HP:0008362)2.79786518
38Turricephaly (HP:0000262)2.79691353
39Insulin resistance (HP:0000855)2.76604823
40Irregular vertebral endplates (HP:0003301)2.76039725
41Abnormality of the phalanges of the 2nd finger (HP:0009541)2.75268494
42Genital tract atresia (HP:0001827)2.72815580
43Coronal craniosynostosis (HP:0004440)2.69731545
44Vaginal atresia (HP:0000148)2.68919405
45Increased corneal curvature (HP:0100692)2.63512582
46Keratoconus (HP:0000563)2.63512582
47Arterial tortuosity (HP:0005116)2.63331176
48Absent septum pellucidum (HP:0001331)2.62056014
49Abnormality of the intrinsic pathway (HP:0010989)2.61401307
50Flat capital femoral epiphysis (HP:0003370)2.59574049
51True hermaphroditism (HP:0010459)2.56077575
52Abnormality of the vertebral endplates (HP:0005106)2.55157506
53Hypoplastic ischia (HP:0003175)2.55125659
54Trigonocephaly (HP:0000243)2.54897296
55Bilateral microphthalmos (HP:0007633)2.54258866
56Soft skin (HP:0000977)2.53499705
57Exercise-induced muscle cramps (HP:0003710)2.52186901
58Enlarged epiphyses (HP:0010580)2.51637127
59Abnormality of the diencephalon (HP:0010662)2.50644012
60Abnormality of renin-angiotensin system (HP:0000847)2.49506766
61Abnormality of potassium homeostasis (HP:0011042)2.45806685
62Gait imbalance (HP:0002141)2.44718164
63Unilateral renal agenesis (HP:0000122)2.43808037
64Maternal diabetes (HP:0009800)2.42921892
65Metaphyseal irregularity (HP:0003025)2.42224493
66Vertebral clefting (HP:0008428)2.42076663
67Vascular tortuosity (HP:0004948)2.40434341
68Hepatoblastoma (HP:0002884)2.40368189
69Medial flaring of the eyebrow (HP:0010747)2.39378254
70Abnormality of the ischium (HP:0003174)2.38899082
71Abdominal distention (HP:0003270)2.38645606
72Prominent supraorbital ridges (HP:0000336)2.37165924
73Metaphyseal cupping (HP:0003021)2.37009148
74Pulmonary artery stenosis (HP:0004415)2.36841364
75Abnormality of abdominal situs (HP:0011620)2.33376731
76Abdominal situs inversus (HP:0003363)2.33376731
77Scotoma (HP:0000575)2.32137878
78Ketosis (HP:0001946)2.31169667
79Myelomeningocele (HP:0002475)2.29870264
80Prominent metopic ridge (HP:0005487)2.29440693
81Congenital primary aphakia (HP:0007707)2.28477832
82Abnormal tarsal ossification (HP:0008369)2.28125547
83Agitation (HP:0000713)2.28052758
84Hyperactive renin-angiotensin system (HP:0000841)2.27452985
85Hyperparathyroidism (HP:0000843)2.27212526
86Abnormal vertebral ossification (HP:0100569)2.25453533
87Optic nerve hypoplasia (HP:0000609)2.25267771
88Choroideremia (HP:0001139)2.24770154
89Abnormality of the aortic arch (HP:0012303)2.21930091
90Bicornuate uterus (HP:0000813)2.21006632
91Gout (HP:0001997)2.17751919
92Abnormality of the metopic suture (HP:0005556)2.16901708
93Broad metatarsal (HP:0001783)2.15010343
94Abnormality of the septum pellucidum (HP:0007375)2.11137527
95Anencephaly (HP:0002323)2.08765297
96Abnormality of midbrain morphology (HP:0002418)2.08279170
97Molar tooth sign on MRI (HP:0002419)2.08279170
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06337021
99Short tibia (HP:0005736)2.06211083
100EEG with generalized epileptiform discharges (HP:0011198)2.05659564
101Pancreatic fibrosis (HP:0100732)2.03013717
102Renal hypoplasia (HP:0000089)2.02876276
103Hypsarrhythmia (HP:0002521)2.02800789
104Short 4th metacarpal (HP:0010044)2.02278325
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02278325
106Hypophosphatemia (HP:0002148)2.01945438
107Increased circulating renin level (HP:0000848)2.00618384
108Papilledema (HP:0001085)1.99013768
109Exostoses (HP:0100777)1.98853432
110Partial duplication of the phalanx of hand (HP:0009999)1.98605507
111Vitreoretinal degeneration (HP:0000655)1.98232639
112Epileptiform EEG discharges (HP:0011182)1.97397488
113Abnormality of the pubic bones (HP:0003172)1.96849785
114Nephrogenic diabetes insipidus (HP:0009806)1.96448056
115Beaking of vertebral bodies (HP:0004568)1.95193458
116Hyperphosphaturia (HP:0003109)1.94612588
117Hyperglycinuria (HP:0003108)1.94175241
118Cervical subluxation (HP:0003308)1.92415544
119Retinal atrophy (HP:0001105)1.92414669
120Abnormality of the middle phalanges of the toes (HP:0010183)1.91172947
121Distal arthrogryposis (HP:0005684)1.91133183
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.90661675
123Broad toe (HP:0001837)1.90457611
124Hypokalemic alkalosis (HP:0001949)1.90020748
125Irregular epiphyses (HP:0010582)1.89503459
126Congenital diaphragmatic hernia (HP:0000776)1.88797728
127Hypothermia (HP:0002045)1.88754759
128Small epiphyses (HP:0010585)1.88507079
129Complement deficiency (HP:0004431)1.87043528
130Conjugated hyperbilirubinemia (HP:0002908)1.86733700
131Disproportionate short-trunk short stature (HP:0003521)1.86616392
132Midline defect of the nose (HP:0004122)1.86061549
133Platyspondyly (HP:0000926)1.85453056
134Severe short stature (HP:0003510)1.85388612
135Aplasia/Hypoplasia of the lens (HP:0008063)1.84386013
136Rib fusion (HP:0000902)1.83939133
137Choanal stenosis (HP:0000452)1.82990093
138Bifid tongue (HP:0010297)1.82788391
139Genu varum (HP:0002970)1.80839104
140Hyperkalemia (HP:0002153)1.79988588
141Congenital glaucoma (HP:0001087)1.78980098
142Limb hypertonia (HP:0002509)1.78502680
143Widely patent fontanelles and sutures (HP:0004492)1.77190867
144Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76663713
145Thin bony cortex (HP:0002753)1.76619246
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76530204
147Pheochromocytoma (HP:0002666)1.76375272
148Chronic hepatic failure (HP:0100626)1.75988112
149Reticulocytopenia (HP:0001896)1.75964834
150Dysautonomia (HP:0002459)1.75838993
151Myokymia (HP:0002411)1.75663510
152Hypoplastic pelvis (HP:0008839)1.75659791
153Flattened epiphyses (HP:0003071)1.75464410
154Broad foot (HP:0001769)1.75192493
155Severe Myopia (HP:0011003)1.74904518
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.74783655
157Anosmia (HP:0000458)1.74567585
158Elevated alkaline phosphatase (HP:0003155)1.73863059
159Stenosis of the external auditory canal (HP:0000402)1.73014464
160Wide cranial sutures (HP:0010537)1.72468628
161Abnormal foot bone ossification (HP:0010675)1.72321859
162Cutaneous finger syndactyly (HP:0010554)1.72168722
163Type 1 muscle fiber predominance (HP:0003803)1.71897253
164Hypoplasia of the fovea (HP:0007750)1.70563605
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.70563605
166Poor coordination (HP:0002370)1.70492213
167Abnormality of alkaline phosphatase activity (HP:0004379)1.70272472
168Rocker bottom foot (HP:0001838)1.68663831
169Osteoarthritis (HP:0002758)1.68456097
170Nausea (HP:0002018)1.68037868
171Shallow orbits (HP:0000586)1.67914141
172Muscle fiber inclusion bodies (HP:0100299)1.67741315
173Epidermoid cyst (HP:0200040)1.66412097
174Abnormal eating behavior (HP:0100738)1.65447957
175Sclerocornea (HP:0000647)1.65344571
176Fibular hypoplasia (HP:0003038)1.64947889
177Broad hallux (HP:0010055)1.64775615
178Median cleft lip (HP:0000161)1.64637574
179Abnormality of the fovea (HP:0000493)1.63643656
180Abnormality of purine metabolism (HP:0004352)1.63456021
181Mild short stature (HP:0003502)1.63176537
182Visual hallucinations (HP:0002367)1.62299400
183Exocrine pancreatic insufficiency (HP:0001738)1.60731022
184Hypoplasia of the odontoid process (HP:0003311)1.59467326
185Flat acetabular roof (HP:0003180)1.58859032
186Abnormal enzyme/coenzyme activity (HP:0012379)1.57944102
187Abnormality of chloride homeostasis (HP:0011422)1.56660344
188Abnormal urine phosphate concentration (HP:0012599)1.56276700
189Abnormal glycosylation (HP:0012345)1.54700399
190Abnormal protein N-linked glycosylation (HP:0012347)1.54700399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.73461297
2PASK6.27085628
3EPHB23.94436560
4MAPK153.79686886
5PRKD33.70439365
6EPHA43.68903906
7TNIK3.58038082
8HIPK23.05991619
9MAP3K22.88184725
10OBSCN2.86913726
11FRK2.66873553
12NTRK32.37769837
13TAOK32.13687904
14WNK42.10543128
15NTRK12.10440142
16TGFBR21.95648060
17FLT31.95244870
18PDGFRA1.92066136
19DYRK31.85825401
20ERN11.85534349
21EPHA31.79236780
22PNCK1.76908123
23FGFR21.76081152
24MAP3K11.73035682
25GRK11.69963154
26MARK11.68223275
27SCYL21.65770336
28TGFBR11.61598538
29DDR21.52212600
30DYRK21.49387045
31PINK11.48499946
32MET1.45397696
33PIK3CA1.39931085
34PTK21.36003681
35TIE11.35784741
36MKNK11.35727576
37PLK41.34899891
38IRAK11.34774423
39TRIB31.32630080
40LATS11.32087291
41PHKG21.29204390
42PHKG11.29204390
43MAPK71.28031059
44WEE11.27940943
45CDC42BPA1.25838667
46PRKCH1.22613953
47PTK61.20489715
48UHMK11.19564615
49CAMKK21.19081641
50STK241.18200170
51SIK11.17208016
52NTRK21.15489512
53PAK31.15257702
54MAP2K71.12601567
55PRKD21.09951627
56STK391.09629795
57DYRK1B1.05029642
58AKT31.04585027
59NUAK11.03265309
60WNK31.00877353
61STK160.98529171
62MAP2K40.97359614
63STK30.95839776
64STK38L0.94622755
65NEK20.93553298
66NLK0.92970415
67PKN10.92646536
68BRSK20.90433303
69VRK10.88496940
70FGFR10.88192146
71TYRO30.87309920
72CDK190.86951918
73DMPK0.85799250
74MAP2K20.83626714
75MAP4K20.81425078
76PRKCE0.81267012
77IRAK20.80105109
78IRAK30.79328662
79FER0.79088803
80MAPK130.77854069
81BCKDK0.76957262
82CDK30.74617925
83PLK20.71255137
84MKNK20.68207011
85KSR20.64406709
86WNK10.63987517
87ERBB30.63746124
88MOS0.62298234
89EIF2AK30.61145894
90PLK30.58083853
91RET0.57210410
92RPS6KA40.55578338
93MAP3K30.54234883
94KIT0.52767477
95PRKACB0.52545057
96CAMK2A0.52198400
97PRKG10.51452409
98PDK20.51244268
99MINK10.50978806
100MAPK40.50668133
101BRD40.48599383
102PRKD10.48358895
103DYRK1A0.47457581
104SGK20.47440127
105PRKCI0.46241114
106BRAF0.45478548
107ROCK20.44938980
108SGK2230.44670275
109SGK4940.44670275
110GSK3A0.44491735
111CAMK2D0.44152494
112JAK20.43338331
113ZAK0.43113450
114RPS6KA20.42212969
115TRIM280.42049814
116PRKAA10.41914389
117TAF10.41282983
118NEK60.41186640
119CDK50.40555970
120OXSR10.39476878
121PRKCG0.39281538
122CAMK2G0.38414050
123PTK2B0.38204396
124GRK50.38066336
125CSNK1A10.37958629
126BCR0.37807556
127PDGFRB0.36948365
128JAK30.36765402
129GRK70.36233296
130BMPR1B0.35885104
131PRKACG0.35741595
132ERBB20.35353602
133CASK0.35208136
134PAK20.34969546
135STK110.34923750
136PRKACA0.34077164
137PRKG20.33696720
138NME10.33116443
139IGF1R0.32461514
140MAP3K100.31815565
141SGK30.31657901
142MTOR0.31098350
143ITK0.31008394
144TESK10.30976933
145NEK10.30107774
146MAP2K10.29519457
147BMPR20.27510966
148CAMKK10.27320622
149MAP3K40.26659794
150ADRBK10.26339972
151PRKDC0.24487060
152CAMK2B0.23885997
153MARK20.23740294
154MARK30.22921987
155PRKCA0.21553391
156SGK10.21421549
157RPS6KB10.21403623
158MAPK140.20959803
159MAPK100.20843251
160AKT10.19946360
161RPS6KA30.18718572
162LATS20.18030304
163DAPK20.17847648

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.76989042
2Protein export_Homo sapiens_hsa030605.22858250
3Cyanoamino acid metabolism_Homo sapiens_hsa004605.01338641
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.09632920
5Insulin secretion_Homo sapiens_hsa049113.28766754
6Sulfur metabolism_Homo sapiens_hsa009203.19380967
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.08614704
8Type II diabetes mellitus_Homo sapiens_hsa049302.38940994
9Cardiac muscle contraction_Homo sapiens_hsa042602.27633227
10Oxidative phosphorylation_Homo sapiens_hsa001902.17610060
11Vibrio cholerae infection_Homo sapiens_hsa051102.01210800
12Parkinsons disease_Homo sapiens_hsa050121.95241226
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.93379239
14Phototransduction_Homo sapiens_hsa047441.81476960
15Ribosome_Homo sapiens_hsa030101.80744735
16N-Glycan biosynthesis_Homo sapiens_hsa005101.78199720
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76294802
18Type I diabetes mellitus_Homo sapiens_hsa049401.67075295
19Sulfur relay system_Homo sapiens_hsa041221.66668061
20Cocaine addiction_Homo sapiens_hsa050301.64272055
21Selenocompound metabolism_Homo sapiens_hsa004501.61599872
22Alzheimers disease_Homo sapiens_hsa050101.50021041
23Steroid biosynthesis_Homo sapiens_hsa001001.48338386
24Axon guidance_Homo sapiens_hsa043601.47683487
25Propanoate metabolism_Homo sapiens_hsa006401.43448930
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.39906010
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39763453
28Nitrogen metabolism_Homo sapiens_hsa009101.38182179
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37870641
30Amphetamine addiction_Homo sapiens_hsa050311.36565542
31Glutathione metabolism_Homo sapiens_hsa004801.32708448
32TGF-beta signaling pathway_Homo sapiens_hsa043501.27864152
33Huntingtons disease_Homo sapiens_hsa050161.26753595
34Hippo signaling pathway_Homo sapiens_hsa043901.26051569
35Fat digestion and absorption_Homo sapiens_hsa049751.25827486
36Lysosome_Homo sapiens_hsa041421.24239213
37Taste transduction_Homo sapiens_hsa047421.21578491
38Vitamin digestion and absorption_Homo sapiens_hsa049771.19414174
39Arachidonic acid metabolism_Homo sapiens_hsa005901.18716201
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17472204
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17252446
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16940054
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14287539
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.14134411
45Histidine metabolism_Homo sapiens_hsa003401.13870857
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13502977
47Glucagon signaling pathway_Homo sapiens_hsa049221.11845225
48Thyroid hormone synthesis_Homo sapiens_hsa049181.09856526
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07140393
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06130133
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05108047
52Other glycan degradation_Homo sapiens_hsa005111.04816981
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04454392
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02328635
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01401909
56Retinol metabolism_Homo sapiens_hsa008301.01234483
57Circadian rhythm_Homo sapiens_hsa047101.00865578
58Butanoate metabolism_Homo sapiens_hsa006501.00329691
59Insulin resistance_Homo sapiens_hsa049311.00152008
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98836466
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98560628
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98269058
63Circadian entrainment_Homo sapiens_hsa047130.97745574
64Protein digestion and absorption_Homo sapiens_hsa049740.97620316
65Fatty acid elongation_Homo sapiens_hsa000620.97493008
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97295935
67Long-term potentiation_Homo sapiens_hsa047200.97147267
68PPAR signaling pathway_Homo sapiens_hsa033200.96971439
69Pancreatic secretion_Homo sapiens_hsa049720.95490829
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94093419
71Chemical carcinogenesis_Homo sapiens_hsa052040.93301079
72Pyruvate metabolism_Homo sapiens_hsa006200.89906030
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89638566
74Dopaminergic synapse_Homo sapiens_hsa047280.87958848
75Caffeine metabolism_Homo sapiens_hsa002320.87415459
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86527617
77Cholinergic synapse_Homo sapiens_hsa047250.84219865
78Arginine and proline metabolism_Homo sapiens_hsa003300.84173946
79Fatty acid degradation_Homo sapiens_hsa000710.82996166
80Galactose metabolism_Homo sapiens_hsa000520.81976307
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81833961
82Peroxisome_Homo sapiens_hsa041460.81445335
83Starch and sucrose metabolism_Homo sapiens_hsa005000.81109781
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80535391
85Tryptophan metabolism_Homo sapiens_hsa003800.78810177
86Collecting duct acid secretion_Homo sapiens_hsa049660.78584958
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78193942
88Estrogen signaling pathway_Homo sapiens_hsa049150.78133432
89Synaptic vesicle cycle_Homo sapiens_hsa047210.77246018
90Tight junction_Homo sapiens_hsa045300.76750788
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76060777
92GABAergic synapse_Homo sapiens_hsa047270.75204571
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74802755
94Prolactin signaling pathway_Homo sapiens_hsa049170.74550383
95Folate biosynthesis_Homo sapiens_hsa007900.73256987
96Regulation of autophagy_Homo sapiens_hsa041400.71591104
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69412692
98Prion diseases_Homo sapiens_hsa050200.68766268
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68312015
100Tyrosine metabolism_Homo sapiens_hsa003500.67165189
101Dorso-ventral axis formation_Homo sapiens_hsa043200.65142871
102Complement and coagulation cascades_Homo sapiens_hsa046100.64848731
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64685613
104Nicotine addiction_Homo sapiens_hsa050330.64621359
105Melanogenesis_Homo sapiens_hsa049160.64368489
106Serotonergic synapse_Homo sapiens_hsa047260.64283636
107Ether lipid metabolism_Homo sapiens_hsa005650.63842765
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62946128
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.60969637
110Fatty acid metabolism_Homo sapiens_hsa012120.59296204
111Sphingolipid metabolism_Homo sapiens_hsa006000.58245368
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57980241
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57969384
114Olfactory transduction_Homo sapiens_hsa047400.57468139
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.57453061
116Bile secretion_Homo sapiens_hsa049760.54966753
117Adherens junction_Homo sapiens_hsa045200.54269779
118Lysine degradation_Homo sapiens_hsa003100.53929861
119Insulin signaling pathway_Homo sapiens_hsa049100.53464660
120Renin secretion_Homo sapiens_hsa049240.52308408
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52028439
122Morphine addiction_Homo sapiens_hsa050320.51997797
123Hedgehog signaling pathway_Homo sapiens_hsa043400.51183734
124Calcium signaling pathway_Homo sapiens_hsa040200.50220087
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49328604
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49301107
127beta-Alanine metabolism_Homo sapiens_hsa004100.49014406
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46358221
129Alcoholism_Homo sapiens_hsa050340.44855303
130ABC transporters_Homo sapiens_hsa020100.44480427
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43682234
132Prostate cancer_Homo sapiens_hsa052150.43652820
133cAMP signaling pathway_Homo sapiens_hsa040240.42509260
134Pathways in cancer_Homo sapiens_hsa052000.42333628
135Thyroid cancer_Homo sapiens_hsa052160.41475328
136Phenylalanine metabolism_Homo sapiens_hsa003600.38795691
137ECM-receptor interaction_Homo sapiens_hsa045120.38637736
138Glutamatergic synapse_Homo sapiens_hsa047240.37512524
139Wnt signaling pathway_Homo sapiens_hsa043100.35657699
140mTOR signaling pathway_Homo sapiens_hsa041500.35565352
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34963800
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33145911
143Ovarian steroidogenesis_Homo sapiens_hsa049130.32584439
144Gap junction_Homo sapiens_hsa045400.31329748
145Gastric acid secretion_Homo sapiens_hsa049710.31162321
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30665608
147Bladder cancer_Homo sapiens_hsa052190.27586480
148Dilated cardiomyopathy_Homo sapiens_hsa054140.27230097
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26879277
150AMPK signaling pathway_Homo sapiens_hsa041520.26865550
151Long-term depression_Homo sapiens_hsa047300.26357964
152Focal adhesion_Homo sapiens_hsa045100.25740859
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24469848
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23081419
155Basal cell carcinoma_Homo sapiens_hsa052170.23010624
156GnRH signaling pathway_Homo sapiens_hsa049120.22334222
157Linoleic acid metabolism_Homo sapiens_hsa005910.22169396
158Fructose and mannose metabolism_Homo sapiens_hsa000510.22069313
159Glioma_Homo sapiens_hsa052140.21309606
160Salivary secretion_Homo sapiens_hsa049700.20840770
161Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20497584
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19249737
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.18939145

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