FSCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.90843964
2spermatid development (GO:0007286)9.70931418
3reproduction (GO:0000003)9.59868332
4motile cilium assembly (GO:0044458)9.27192727
5regulation of cilium movement (GO:0003352)9.00765742
6cilium movement (GO:0003341)8.13323025
7protein targeting to Golgi (GO:0000042)8.07682833
8establishment of protein localization to Golgi (GO:0072600)7.76216666
9single fertilization (GO:0007338)7.72497263
10response to pheromone (GO:0019236)7.64946975
11rRNA methylation (GO:0031167)7.64296538
12retrograde transport, vesicle recycling within Golgi (GO:0000301)7.54420661
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.54128859
14sperm capacitation (GO:0048240)7.27430034
15piRNA metabolic process (GO:0034587)7.25343979
16male meiosis (GO:0007140)7.12287506
17synaptonemal complex organization (GO:0070193)7.00538373
18synaptonemal complex assembly (GO:0007130)6.78175100
19centriole replication (GO:0007099)6.77487247
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.69021415
21negative regulation of inclusion body assembly (GO:0090084)6.68971105
22spermatogenesis (GO:0007283)6.62432813
23male gamete generation (GO:0048232)6.60027008
24fertilization (GO:0009566)6.51247603
25organic cation transport (GO:0015695)6.47811435
26rRNA modification (GO:0000154)6.46089346
27microtubule depolymerization (GO:0007019)6.36640204
28phosphatidylethanolamine metabolic process (GO:0046337)6.17255049
29gamete generation (GO:0007276)6.06817306
30protein localization to Golgi apparatus (GO:0034067)5.79083802
31regulation of inclusion body assembly (GO:0090083)5.64501119
32calcium ion-dependent exocytosis (GO:0017156)5.51611661
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.46836719
34ventricular system development (GO:0021591)5.43938850
35germ cell development (GO:0007281)5.43162985
36regulation of centriole replication (GO:0046599)5.43134635
37regulation of microtubule-based movement (GO:0060632)5.34059098
38cell recognition (GO:0008037)5.07563594
39regulation of Rab GTPase activity (GO:0032313)5.02118747
40positive regulation of Rab GTPase activity (GO:0032851)5.02118747
41male meiosis I (GO:0007141)4.95488002
42multicellular organismal reproductive process (GO:0048609)4.79161811
43glycerol ether metabolic process (GO:0006662)4.76578276
44microtubule severing (GO:0051013)4.76471615
45chromosome condensation (GO:0030261)4.65775978
46chromosome organization involved in meiosis (GO:0070192)4.64749148
47seminiferous tubule development (GO:0072520)4.63974765
48DNA methylation involved in gamete generation (GO:0043046)4.63333322
49cellular ketone body metabolic process (GO:0046950)4.61150503
50spermatid nucleus differentiation (GO:0007289)4.52398187
51regulation of transcription involved in cell fate commitment (GO:0060850)4.49719488
52DNA packaging (GO:0006323)4.47297414
53left/right pattern formation (GO:0060972)4.41165381
54ether metabolic process (GO:0018904)4.40390709
55musculoskeletal movement (GO:0050881)4.25077478
56multicellular organismal movement (GO:0050879)4.25077478
57meiotic nuclear division (GO:0007126)4.24759221
58chromatin silencing (GO:0006342)4.21919974
59glomerular visceral epithelial cell development (GO:0072015)4.08131574
60ketone body metabolic process (GO:1902224)4.07202850
61microtubule nucleation (GO:0007020)4.06061530
62meiosis I (GO:0007127)3.95999460
63chaperone-mediated protein complex assembly (GO:0051131)3.87483618
64glomerular epithelial cell development (GO:0072310)3.86484504
65multicellular organismal development (GO:0007275)3.84560171
66genitalia morphogenesis (GO:0035112)3.79180794
67protein polyglutamylation (GO:0018095)3.73165980
68monoubiquitinated protein deubiquitination (GO:0035520)3.68416963
69sexual reproduction (GO:0019953)3.51232363
70membrane protein intracellular domain proteolysis (GO:0031293)3.50078232
71single strand break repair (GO:0000012)3.47293608
72sequestering of actin monomers (GO:0042989)3.44750797
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42950478
74protein localization to cilium (GO:0061512)3.40447239
75meiotic cell cycle (GO:0051321)3.38316441
76regulation of spindle checkpoint (GO:0090231)3.31666426
77protein refolding (GO:0042026)3.29264013
78microtubule polymerization or depolymerization (GO:0031109)3.25660310
79amino-acid betaine transport (GO:0015838)3.23580598
80carnitine transport (GO:0015879)3.23580598
81response to acidic pH (GO:0010447)3.22701716
82regulation of interleukin-13 production (GO:0032656)3.21314372
83protein-DNA complex disassembly (GO:0032986)3.19690439
84nucleosome disassembly (GO:0006337)3.19690439
85negative regulation of Rho protein signal transduction (GO:0035024)3.19628456
86cellular response to pH (GO:0071467)3.16626981
87homeostasis of number of cells within a tissue (GO:0048873)3.16232530
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.14028902
89glycolytic process (GO:0006096)3.13613914
90cerebral cortex neuron differentiation (GO:0021895)3.10717454
91protein K11-linked deubiquitination (GO:0035871)3.09073133
92protein depolymerization (GO:0051261)3.08423726
93intra-Golgi vesicle-mediated transport (GO:0006891)3.08043147
94nucleus organization (GO:0006997)3.07307773
95carnitine transmembrane transport (GO:1902603)3.06780444
96polyol catabolic process (GO:0046174)3.05868702
97coenzyme catabolic process (GO:0009109)3.05152207
98RNA localization (GO:0006403)3.05136311
99centrosome duplication (GO:0051298)3.04731468
100Golgi to endosome transport (GO:0006895)3.04228345
101DNA conformation change (GO:0071103)2.98345567
102mitotic sister chromatid cohesion (GO:0007064)2.97236080
103nucleoside diphosphate phosphorylation (GO:0006165)2.96669905
104peptidyl-threonine dephosphorylation (GO:0035970)2.96379334
105histone H3-K9 demethylation (GO:0033169)2.95330618
106receptor recycling (GO:0001881)2.93434596
107regulation of T-helper 2 cell differentiation (GO:0045628)2.92885120
108alditol metabolic process (GO:0019400)2.91237632
109RNA destabilization (GO:0050779)2.90926585
110cilium organization (GO:0044782)2.90296512
111interferon-gamma secretion (GO:0072643)2.88304187
112microtubule-based movement (GO:0007018)2.86420951
113mitotic G1 DNA damage checkpoint (GO:0031571)2.86254746
114positive regulation of guanylate cyclase activity (GO:0031284)2.84935887
115negative regulation of gene expression, epigenetic (GO:0045814)2.84066366
116negative regulation of organelle assembly (GO:1902116)2.83780253
117intraciliary transport (GO:0042073)2.80932271
118lactate metabolic process (GO:0006089)2.79602676
119mitochondrial fission (GO:0000266)2.78662296
120cilium assembly (GO:0042384)2.77949740
121synapsis (GO:0007129)2.77739163
122meiotic cell cycle process (GO:1903046)2.76198157
123axoneme assembly (GO:0035082)2.74634465
124cellular component assembly involved in morphogenesis (GO:0010927)2.72290748
125GTP biosynthetic process (GO:0006183)2.71719078
126cilium morphogenesis (GO:0060271)2.71307202
127positive regulation of macrophage activation (GO:0043032)2.69349989
128gene silencing by RNA (GO:0031047)2.67355543
129peptidyl-glutamic acid modification (GO:0018200)2.63037340
130nuclear pore complex assembly (GO:0051292)2.61248886
131regulation of cilium assembly (GO:1902017)2.60550079
132polyamine biosynthetic process (GO:0006596)2.56606800
133centriole assembly (GO:0098534)2.44940591
134negative regulation of skeletal muscle tissue development (GO:0048642)2.42826343
135fusion of sperm to egg plasma membrane (GO:0007342)14.0326016
136sperm motility (GO:0030317)13.9927592
137cell wall macromolecule catabolic process (GO:0016998)12.2537107
138cell wall macromolecule metabolic process (GO:0044036)12.2537107
139acrosome reaction (GO:0007340)12.0873609
140sperm-egg recognition (GO:0035036)11.7135937
141acrosome assembly (GO:0001675)11.4206287
142multicellular organism reproduction (GO:0032504)11.3376432
143plasma membrane fusion (GO:0045026)10.6958755
144binding of sperm to zona pellucida (GO:0007339)10.6065667
145cell-cell recognition (GO:0009988)10.4823941
146cilium or flagellum-dependent cell motility (GO:0001539)10.0692701
147axonemal dynein complex assembly (GO:0070286)10.0040403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.63179721
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.66345555
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.35855769
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.23394657
5EZH2_22144423_ChIP-Seq_EOC_Human4.19312491
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.45630978
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13875346
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09060004
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89972161
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65263447
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48544645
12VDR_22108803_ChIP-Seq_LS180_Human2.38064268
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27726334
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02519090
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02195047
16* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00793051
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.00779661
18ZNF274_21170338_ChIP-Seq_K562_Hela1.99551437
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.97011478
20DROSHA_22980978_ChIP-Seq_HELA_Human1.96890997
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95684179
22RAC3_21632823_ChIP-Seq_H3396_Human1.83800959
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82397388
24ERA_21632823_ChIP-Seq_H3396_Human1.82035841
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.77453086
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76155001
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74908035
28STAT1_17558387_ChIP-Seq_HELA_Human1.72959949
29NANOG_20526341_ChIP-Seq_ESCs_Human1.71483998
30FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70521640
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70365600
32* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69190989
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68951256
34* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.67869577
35* FUS_26573619_Chip-Seq_HEK293_Human1.67559208
36CTCF_27219007_Chip-Seq_Bcells_Human1.67258921
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66461464
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64794715
39TAF2_19829295_ChIP-Seq_ESCs_Human1.57043540
40MYC_19829295_ChIP-Seq_ESCs_Human1.55912355
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55591029
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55165756
43BCL6_27268052_Chip-Seq_Bcells_Human1.54385271
44SMC4_20622854_ChIP-Seq_HELA_Human1.52095972
45* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52094292
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51894230
47CBP_20019798_ChIP-Seq_JUKART_Human1.51894230
48* SMAD4_21741376_ChIP-Seq_EPCs_Human1.48613523
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.47287252
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47255064
51RBPJ_21746931_ChIP-Seq_IB4_Human1.46056914
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45592537
53AR_25329375_ChIP-Seq_VCAP_Human1.45474793
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.45160453
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44375117
56BCOR_27268052_Chip-Seq_Bcells_Human1.44079635
57OCT4_20526341_ChIP-Seq_ESCs_Human1.43317334
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42073394
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41985533
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.41624924
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.41206721
62* KDM2B_26808549_Chip-Seq_REH_Human1.40811565
63* WDR5_24793694_ChIP-Seq_LNCAP_Human1.40393394
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40253781
65P68_20966046_ChIP-Seq_HELA_Human1.40249917
66* TAL1_26923725_Chip-Seq_HPCs_Mouse1.39935359
67* ER_23166858_ChIP-Seq_MCF-7_Human1.39778338
68TP63_22573176_ChIP-Seq_HFKS_Human1.39530325
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.39252387
70ETV1_20927104_ChIP-Seq_GIST48_Human1.38678089
71PHF8_20622854_ChIP-Seq_HELA_Human1.38624519
72E2F1_20622854_ChIP-Seq_HELA_Human1.38397866
73TP53_18474530_ChIP-ChIP_U2OS_Human1.37572514
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35738450
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34812855
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.34137203
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34012415
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32388446
79CEBPB_22108803_ChIP-Seq_LS180_Human1.31316265
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31111944
81P53_21459846_ChIP-Seq_SAOS-2_Human1.30965758
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.29500041
83REST_21632747_ChIP-Seq_MESCs_Mouse1.27863762
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.26947801
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26845918
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.26025628
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25745037
88P300_27268052_Chip-Seq_Bcells_Human1.25401718
89* P300_19829295_ChIP-Seq_ESCs_Human1.24729340
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22365738
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22197677
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22163926
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21857689
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21654980
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21432273
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20415276
97PHF8_20622853_ChIP-Seq_HELA_Human1.20319506
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20284420
99* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20169390
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.19625054
101GF1_26923725_Chip-Seq_HPCs_Mouse1.19264392
102LXR_22292898_ChIP-Seq_THP-1_Human1.18961341
103SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18459348
104TAF15_26573619_Chip-Seq_HEK293_Human1.18420254
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18181148
106* TBL1_22424771_ChIP-Seq_293T_Human1.17855600
107GATA6_21074721_ChIP-Seq_CACO-2_Human1.16720442
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.16703378
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16427288
110P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15959474
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14791107
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14791107
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14346895
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14312954
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12812554
116PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12268734
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.12156873
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11829059
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11812177
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11156812
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10818214
122STAT3_23295773_ChIP-Seq_U87_Human1.10585744
123ERG_20517297_ChIP-Seq_VCAP_Human1.10105359
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.09920900
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09474752
126AR_21572438_ChIP-Seq_LNCaP_Human1.09336992
127NFYA_21822215_ChIP-Seq_K562_Human1.09124579
128SMAD4_21799915_ChIP-Seq_A2780_Human1.08776545
129GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08422813
130RUNX2_22187159_ChIP-Seq_PCA_Human1.08021982
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07982159
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.07934927
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.07024169
134SMRT_27268052_Chip-Seq_Bcells_Human1.06489994
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05795318
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05659587
137SA1_27219007_Chip-Seq_Bcells_Human1.04054986
138RUNX_20019798_ChIP-Seq_JUKART_Human1.03779461
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02849760
140TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.02312362
141MYC_27129775_Chip-Seq_CORNEA_Mouse1.01153110
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00693937
143NANOG_19829295_ChIP-Seq_ESCs_Human1.00635982
144SOX2_19829295_ChIP-Seq_ESCs_Human1.00635982
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.99293142
146KLF5_25053715_ChIP-Seq_YYC3_Human0.98762965
147RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98436418
148OCT4_18555785_Chip-Seq_ESCs_Mouse0.98303050
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.97472990
150P53_22387025_ChIP-Seq_ESCs_Mouse0.96682485
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94951837
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93929205
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93623158
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.92617305
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92355637
156JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91988812
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91812928
158CTCF_20526341_ChIP-Seq_ESCs_Human0.91666071
159SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91190919
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.90987172
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90974451
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90920509
163NFYB_21822215_ChIP-Seq_K562_Human0.90740873
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90691541
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.90356260
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90340246
167ELF1_20517297_ChIP-Seq_JURKAT_Human0.88879258
168KLF4_18555785_Chip-Seq_ESCs_Mouse0.88762929
169SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88470672
170TET1_21451524_ChIP-Seq_MESCs_Mouse0.88314428
171P300_18555785_Chip-Seq_ESCs_Mouse0.88179365
172PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88051253
173KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87552028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07007031
2MP0001929_abnormal_gametogenesis5.46490441
3MP0008877_abnormal_DNA_methylation4.08798837
4MP0001348_abnormal_lacrimal_gland3.73155876
5MP0002210_abnormal_sex_determination3.35621560
6MP0002161_abnormal_fertility/fecundity3.30989741
7MP0005670_abnormal_white_adipose2.88274088
8MP0001145_abnormal_male_reproductive2.85963773
9MP0002653_abnormal_ependyma_morphology2.53744293
10MP0000653_abnormal_sex_gland2.48072889
11MP0003718_maternal_effect2.20379737
12MP0000678_abnormal_parathyroid_gland2.00411429
13MP0005410_abnormal_fertilization16.5019315
14MP0005379_endocrine/exocrine_gland_phen1.96122967
15MP0005451_abnormal_body_composition1.84910204
16MP0001485_abnormal_pinna_reflex1.84830714
17MP0002160_abnormal_reproductive_system1.73253614
18MP0005310_abnormal_salivary_gland1.65312930
19MP0005623_abnormal_meninges_morphology1.63829955
20MP0002132_abnormal_respiratory_system1.61782489
21MP0003646_muscle_fatigue1.60867871
22MP0001486_abnormal_startle_reflex1.59861202
23MP0009053_abnormal_anal_canal1.57199731
24MP0004233_abnormal_muscle_weight1.37975340
25MP0002282_abnormal_trachea_morphology1.35585174
26MP0002822_catalepsy1.28414163
27MP0002249_abnormal_larynx_morphology1.25140927
28MP0004859_abnormal_synaptic_plasticity1.24130142
29MP0001765_abnormal_ion_homeostasis1.18551860
30MP0001963_abnormal_hearing_physiology1.17758104
31MP0002138_abnormal_hepatobiliary_system1.11760255
32MP0002735_abnormal_chemical_nociception0.98907807
33MP0005395_other_phenotype0.98888354
34MP0000026_abnormal_inner_ear0.98858008
35MP0002127_abnormal_cardiovascular_syste0.98620355
36MP0001984_abnormal_olfaction0.97083364
37MP0004510_myositis0.92811080
38MP0005248_abnormal_Harderian_gland0.92184166
39MP0005647_abnormal_sex_gland0.91795791
40MP0008995_early_reproductive_senescence0.91038515
41MP0009046_muscle_twitch0.88304236
42MP0005389_reproductive_system_phenotype0.87782840
43MP0000955_abnormal_spinal_cord0.80627944
44MP0003115_abnormal_respiratory_system0.80507447
45MP0003878_abnormal_ear_physiology0.78504631
46MP0005377_hearing/vestibular/ear_phenot0.78504631
47MP0008058_abnormal_DNA_repair0.75232320
48MP0002067_abnormal_sensory_capabilities0.74941968
49MP0009697_abnormal_copulation0.74267766
50MP0001905_abnormal_dopamine_level0.73383090
51MP0008569_lethality_at_weaning0.73263853
52MP0005083_abnormal_biliary_tract0.72581559
53MP0003077_abnormal_cell_cycle0.68012501
54MP0002557_abnormal_social/conspecific_i0.65876782
55MP0005367_renal/urinary_system_phenotyp0.65461507
56MP0000516_abnormal_urinary_system0.65461507
57MP0001879_abnormal_lymphatic_vessel0.64401537
58MP0000681_abnormal_thyroid_gland0.63946451
59MP0005636_abnormal_mineral_homeostasis0.63668354
60MP0004085_abnormal_heartbeat0.62732882
61MP0005167_abnormal_blood-brain_barrier0.62359016
62MP0005666_abnormal_adipose_tissue0.62317311
63MP0003011_delayed_dark_adaptation0.61153251
64MP0002234_abnormal_pharynx_morphology0.57879627
65MP0000049_abnormal_middle_ear0.57466533
66MP0001666_abnormal_nutrient_absorption0.57264572
67MP0002733_abnormal_thermal_nociception0.56417382
68MP0002572_abnormal_emotion/affect_behav0.56232354
69MP0000569_abnormal_digit_pigmentation0.55053948
70MP0001324_abnormal_eye_pigmentation0.53314248
71MP0000358_abnormal_cell_content/0.52274601
72MP0010094_abnormal_chromosome_stability0.51160215
73MP0003329_amyloid_beta_deposits0.50222698
74MP0004036_abnormal_muscle_relaxation0.50125698
75MP0003699_abnormal_female_reproductive0.49820315
76MP0003950_abnormal_plasma_membrane0.48495926
77MP0004484_altered_response_of0.47987976
78MP0005535_abnormal_body_temperature0.47916446
79MP0000230_abnormal_systemic_arterial0.46967150
80MP0009745_abnormal_behavioral_response0.46598303
81MP0001764_abnormal_homeostasis0.46525911
82MP0009278_abnormal_bone_marrow0.46441915
83MP0001293_anophthalmia0.46114164
84MP0005397_hematopoietic_system_phenotyp0.45944768
85MP0001545_abnormal_hematopoietic_system0.45944768
86MP0002928_abnormal_bile_duct0.45804780
87MP0002272_abnormal_nervous_system0.45470111
88MP0010329_abnormal_lipoprotein_level0.44108322
89MP0002269_muscular_atrophy0.43780468
90MP0003137_abnormal_impulse_conducting0.42146533
91MP0000003_abnormal_adipose_tissue0.41711676
92MP0002734_abnormal_mechanical_nocicepti0.40475800
93MP0009115_abnormal_fat_cell0.39405092
94MP0005253_abnormal_eye_physiology0.38983888
95MP0000534_abnormal_ureter_morphology0.38782915
96MP0000249_abnormal_blood_vessel0.37858439
97MP0005551_abnormal_eye_electrophysiolog0.37691116
98MP0005595_abnormal_vascular_smooth0.37045294
99MP0001501_abnormal_sleep_pattern0.36958375
100MP0006036_abnormal_mitochondrial_physio0.36101479
101MP0001970_abnormal_pain_threshold0.35898487
102MP0005084_abnormal_gallbladder_morpholo0.35705807
103MP0005408_hypopigmentation0.34418293
104MP0002971_abnormal_brown_adipose0.33938833
105MP0004084_abnormal_cardiac_muscle0.33685723
106MP0004957_abnormal_blastocyst_morpholog0.32644098
107MP0005332_abnormal_amino_acid0.32410238
108MP0003786_premature_aging0.32068184
109MP0000613_abnormal_salivary_gland0.32018106
110MP0005391_vision/eye_phenotype0.31143604
111MP0003111_abnormal_nucleus_morphology0.30910250
112MP0003942_abnormal_urinary_system0.30544234
113MP0003879_abnormal_hair_cell0.29826883
114MP0008961_abnormal_basal_metabolism0.29538831
115MP0002736_abnormal_nociception_after0.28879232
116MP0003633_abnormal_nervous_system0.28459896
117MP0002295_abnormal_pulmonary_circulatio0.27992629
118MP0004811_abnormal_neuron_physiology0.27730006
119MP0001119_abnormal_female_reproductive0.26887568
120MP0008057_abnormal_DNA_replication0.25501359
121MP0000604_amyloidosis0.24519127
122MP0001730_embryonic_growth_arrest0.24458594
123MP0004019_abnormal_vitamin_homeostasis0.24403495
124MP0003861_abnormal_nervous_system0.24079675
125MP0001661_extended_life_span0.23969002
126MP0008007_abnormal_cellular_replicative0.23712419
127MP0004133_heterotaxia0.23697141
128MP0002139_abnormal_hepatobiliary_system0.23696185
129MP0003948_abnormal_gas_homeostasis0.22983235
130MP0002102_abnormal_ear_morphology0.22589443
131MP0000751_myopathy0.22579676
132MP0001727_abnormal_embryo_implantation0.22329287
133MP0002152_abnormal_brain_morphology0.22274642
134MP0005375_adipose_tissue_phenotype0.21755348
135MP0004270_analgesia0.21501944
136MP0003631_nervous_system_phenotype0.21364569
137MP0006035_abnormal_mitochondrial_morpho0.21038924
138MP0004742_abnormal_vestibular_system0.19752732
139MP0002169_no_abnormal_phenotype0.19578615
140MP0002873_normal_phenotype0.19335512
141MP0005423_abnormal_somatic_nervous0.19264021
142MP0003959_abnormal_lean_body0.18280745
143MP0002092_abnormal_eye_morphology0.17892198
144MP0010307_abnormal_tumor_latency0.17051750
145MP0003787_abnormal_imprinting0.16691062
146MP0001849_ear_inflammation0.16420717
147MP0003045_fibrosis0.16318328
148MP0001986_abnormal_taste_sensitivity0.16302782
149MP0000313_abnormal_cell_death0.16226191
150MP0004808_abnormal_hematopoietic_stem0.15657671
151MP0004043_abnormal_pH_regulation0.15060761
152MP0008875_abnormal_xenobiotic_pharmacok0.14802217
153MP0002084_abnormal_developmental_patter0.14508342
154MP0002229_neurodegeneration0.14118321
155MP0001968_abnormal_touch/_nociception0.13854272
156MP0009672_abnormal_birth_weight0.13626489
157MP0001440_abnormal_grooming_behavior0.13149242
158MP0002118_abnormal_lipid_homeostasis0.12922564

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.22532240
2Abnormal respiratory motile cilium morphology (HP:0005938)9.19498973
3Abnormal respiratory epithelium morphology (HP:0012253)9.19498973
4Severe visual impairment (HP:0001141)7.48590115
5Rhinitis (HP:0012384)7.41653137
6Abnormal ciliary motility (HP:0012262)7.37437691
7Chronic bronchitis (HP:0004469)7.11692881
8Infertility (HP:0000789)6.88197522
9Nasal polyposis (HP:0100582)6.36492326
10Chronic hepatic failure (HP:0100626)5.84811717
11Abnormality of the nasal mucosa (HP:0000433)5.23684727
12Male infertility (HP:0003251)4.99782283
13Hyperkalemia (HP:0002153)4.75808816
14Bronchitis (HP:0012387)4.60871846
15Resting tremor (HP:0002322)4.58473237
16Bony spicule pigmentary retinopathy (HP:0007737)4.58081022
17Attenuation of retinal blood vessels (HP:0007843)4.54210095
18Cone-rod dystrophy (HP:0000548)4.48864859
19Abnormality of macular pigmentation (HP:0008002)4.47922250
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.42657947
21Bronchiectasis (HP:0002110)4.40938042
22Nephronophthisis (HP:0000090)4.35214091
23Hypoalphalipoproteinemia (HP:0003233)3.94742032
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.83439293
25Abnormal spermatogenesis (HP:0008669)3.80903243
26Progressive sensorineural hearing impairment (HP:0000408)3.70027516
27Facial shape deformation (HP:0011334)3.66695400
28Potter facies (HP:0002009)3.66695400
29Hypoplasia of the thymus (HP:0000778)3.60538280
30Menstrual irregularities (HP:0000858)3.58307247
31Recurrent sinusitis (HP:0011108)3.40193478
32Renovascular hypertension (HP:0100817)3.36940826
33Amelogenesis imperfecta (HP:0000705)3.30610423
34Recurrent otitis media (HP:0000403)3.30559115
35Abnormality of the renal medulla (HP:0100957)3.28461417
36Abnormal rod and cone electroretinograms (HP:0008323)3.22635011
37Hypoplastic ischia (HP:0003175)3.22032087
38Postural instability (HP:0002172)3.18035975
39Progressive cerebellar ataxia (HP:0002073)3.09228279
40Abnormality of dental color (HP:0011073)3.06185109
41Enlarged epiphyses (HP:0010580)3.02861673
42Insulin-resistant diabetes mellitus (HP:0000831)2.97870488
43Recurrent bronchitis (HP:0002837)2.93657822
44Portal hypertension (HP:0001409)2.93351864
45Tubulointerstitial nephritis (HP:0001970)2.92283390
46Abnormality of the ischium (HP:0003174)2.90298145
47Impulsivity (HP:0100710)2.81945785
48Tubular atrophy (HP:0000092)2.71149946
49Abnormality of the hepatic vasculature (HP:0006707)2.69758488
50Abnormality of midbrain morphology (HP:0002418)2.62529175
51Molar tooth sign on MRI (HP:0002419)2.62529175
52Abnormality of potassium homeostasis (HP:0011042)2.55629839
53Tubulointerstitial abnormality (HP:0001969)2.54335482
54Abnormality of the costochondral junction (HP:0000919)2.52698982
55Gonadotropin excess (HP:0000837)2.52264173
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49310878
57Generalized aminoaciduria (HP:0002909)2.44769226
58Abnormal gallbladder physiology (HP:0012438)2.44048235
59Cholecystitis (HP:0001082)2.44048235
60Hyperuricemia (HP:0002149)2.43629320
61Increased purine levels (HP:0004368)2.43629320
62Medial flaring of the eyebrow (HP:0010747)2.38042116
63Azoospermia (HP:0000027)2.38039682
64Progressive hearing impairment (HP:0001730)2.37807812
65Abnormality of the aortic arch (HP:0012303)2.34327683
66Subcapsular cataract (HP:0000523)2.33493810
67Unilateral renal agenesis (HP:0000122)2.32248462
68Intellectual disability, moderate (HP:0002342)2.26649707
69Dyschromatopsia (HP:0007641)2.23534769
70Ventricular tachycardia (HP:0004756)2.23423268
71Focal segmental glomerulosclerosis (HP:0000097)2.11337614
72Myokymia (HP:0002411)2.09214113
73Tubulointerstitial fibrosis (HP:0005576)2.08568553
74Osteomalacia (HP:0002749)2.05816318
75Spastic tetraparesis (HP:0001285)2.04719452
76Choroideremia (HP:0001139)2.02006309
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.4705757
78Absent/shortened dynein arms (HP:0200106)13.4705757
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9679348
80Recurrent pneumonia (HP:0006532)1.96901432
81Hypophosphatemic rickets (HP:0004912)1.95856448
82Hyponatremia (HP:0002902)1.95393971
83Hypolipoproteinemia (HP:0010981)1.95336747
84Widely patent fontanelles and sutures (HP:0004492)1.94672827
85Decreased central vision (HP:0007663)1.92925427
86Abnormality of the parathyroid morphology (HP:0011766)1.89016514
87Heterotopia (HP:0002282)1.88969937
88Postaxial foot polydactyly (HP:0001830)1.86168979
89Flattened epiphyses (HP:0003071)1.86051460
90Abnormal drinking behavior (HP:0030082)1.83789127
91Polydipsia (HP:0001959)1.83789127
92Stage 5 chronic kidney disease (HP:0003774)1.83575067
93Optic nerve hypoplasia (HP:0000609)1.82657526
94Bradycardia (HP:0001662)1.81323235
95Epiphyseal dysplasia (HP:0002656)1.81294145
96Insulin resistance (HP:0000855)1.77256804
97Abnormality of the epiphysis of the femoral head (HP:0010574)1.77159279
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76139549
99Congenital hepatic fibrosis (HP:0002612)1.73677692
100Recurrent corneal erosions (HP:0000495)1.73436891
101Abnormality of the lower motor neuron (HP:0002366)1.73256640
102Renal Fanconi syndrome (HP:0001994)1.72711042
103Congenital sensorineural hearing impairment (HP:0008527)1.72565630
104Abnormality of the renal cortex (HP:0011035)1.72008225
105Sandal gap (HP:0001852)1.70215558
106Glomerulosclerosis (HP:0000096)1.69781564
107Hemorrhage of the eye (HP:0011885)1.69146678
108Bell-shaped thorax (HP:0001591)1.68566918
109Abnormality of renal excretion (HP:0011036)1.67047609
110Occipital encephalocele (HP:0002085)1.66782780
111Photophobia (HP:0000613)1.66756504
112Short ribs (HP:0000773)1.66613296
113Obsessive-compulsive behavior (HP:0000722)1.65635078
114Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.64904584
115Abnormality of femoral epiphyses (HP:0006499)1.64904584
116Abnormality of purine metabolism (HP:0004352)1.63513074
117Bile duct proliferation (HP:0001408)1.62888442
118Abnormal biliary tract physiology (HP:0012439)1.62888442
119Oculomotor apraxia (HP:0000657)1.59062161
120Fibular hypoplasia (HP:0003038)1.53775197
121Abnormality of the dental root (HP:0006486)1.50323032
122Taurodontia (HP:0000679)1.50323032
123Abnormality of permanent molar morphology (HP:0011071)1.50323032
124Renal dysplasia (HP:0000110)1.49901364
125Asymmetric septal hypertrophy (HP:0001670)1.49825866
126Abnormality of dentin (HP:0010299)1.46388710
127Neurofibrillary tangles (HP:0002185)1.45939364
128Postaxial hand polydactyly (HP:0001162)1.45134743
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.44923358
130Amyotrophic lateral sclerosis (HP:0007354)1.44207219
131Absent frontal sinuses (HP:0002688)1.42303884
132Abnormal urine output (HP:0012590)1.39244496
133Deformed sella turcica (HP:0002681)1.39152336
134Aplasia/Hypoplasia of the lens (HP:0008063)1.38976096
135Abnormality of molar morphology (HP:0011070)1.38956858
136Abnormality of molar (HP:0011077)1.38956858
137Absent epiphyses (HP:0010577)1.38431652
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38431652
139Abnormality of the dental pulp (HP:0006479)1.37975841
140Facial cleft (HP:0002006)1.36992372
141Hemiparesis (HP:0001269)1.36422556
142Cystic liver disease (HP:0006706)1.33856335
143Chronic sinusitis (HP:0011109)1.32688256
144Bundle branch block (HP:0011710)1.32122143
145J-shaped sella turcica (HP:0002680)1.31984990
146Microglossia (HP:0000171)1.31929642
147Impaired proprioception (HP:0010831)1.25961764
148Short thorax (HP:0010306)1.24205958
149Cerebral inclusion bodies (HP:0100314)1.23384953
150Nephropathy (HP:0000112)1.23168364
151Broad distal phalanx of finger (HP:0009836)1.22530216
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22463722
153Congenital malformation of the right heart (HP:0011723)1.21852639
154Double outlet right ventricle (HP:0001719)1.21852639
155Pancreatic fibrosis (HP:0100732)1.19934096
156Congenital primary aphakia (HP:0007707)1.19500728
157Gait imbalance (HP:0002141)1.19293640
158Truncal obesity (HP:0001956)1.18510928
159Abnormality of saccadic eye movements (HP:0000570)1.17850695
160Hypercholesterolemia (HP:0003124)1.17079618
161Cerebellar dysplasia (HP:0007033)1.16743319
162Easy fatigability (HP:0003388)1.15522762
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.15246604
164Polyuria (HP:0000103)1.14906698
165Short femoral neck (HP:0100864)1.13651242
166Loss of speech (HP:0002371)1.12062398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.90974632
2PDK47.90974632
3TESK16.54668759
4PRKD35.77476123
5PDK25.11071800
6ICK4.53093762
7INSRR4.08172160
8BRD43.80420949
9DDR23.79571736
10PLK23.63356080
11MAP4K22.56866809
12PTK2B2.40468931
13PNCK2.23580429
14PIK3CG2.17052482
15WNK42.13608016
16STK392.00421626
17STK381.84086612
18MST1R1.64965527
19NEK21.60409537
20DYRK1B1.56714000
21PDK11.14156252
22CDK71.10311527
23CAMK1D0.98533711
24AKT30.98237508
25TYRO30.98121364
26KSR20.87123449
27MAPK150.85117368
28WNK10.84769046
29DYRK30.84591493
30SIK20.80793701
31MAP3K110.74166324
32CAMK1G0.72356834
33PASK0.72239843
34MAP3K90.70327608
35PDPK10.69960030
36LATS20.68731532
37TESK20.64596872
38IRAK10.64590616
39STK30.63810823
40MAP2K60.61970132
41TTK0.61116924
42EEF2K0.60255218
43RPS6KA20.56988711
44CCNB10.56911293
45RIPK40.56856164
46CHEK20.56697509
47TIE10.56574719
48CAMK10.55002534
49SGK4940.54016550
50SGK2230.54016550
51PRKAA20.51909996
52MAP2K20.51172221
53UHMK10.50764966
54LMTK20.50186589
55MAP3K20.48377593
56PINK10.47584743
57CDK30.46989655
58PAK10.43739445
59MARK10.42693188
60ROCK10.41070133
61LATS10.40352248
62CHEK10.39633704
63MAPK10.39302920
64IRAK20.38406130
65PAK20.36332744
66STK38L0.35210114
67MAP3K80.35159127
68NTRK20.33731323
69NTRK30.33421449
70TNIK0.32603182
71MUSK0.32217891
72MTOR0.31807629
73SGK10.31481781
74BMPR1B0.31049230
75NEK60.30426544
76CAMK40.30252936
77PRKCG0.29824749
78ATM0.29566068
79SGK20.27106951
80WEE10.26222658
81RPS6KC10.25983615
82RPS6KL10.25983615
83MARK20.25931182
84ATR0.25527798
85MAP3K100.24381726
86PAK40.23898288
87CAMKK10.23107406
88JAK30.23069979
89RPS6KA60.22886266
90PLK40.22668339
91MAPK140.22560137
92PRKAA10.22246206
93MAPKAPK50.20233363
94MAPK100.18169257
95OXSR10.18146603
96RPS6KB10.17916876
97AKT10.17834741
98CDC70.17775378
99MET0.16456961
100MAPK110.14681137
101PRKCZ0.13391549
102SGK30.12931389
103BRSK20.12650265
104ARAF0.12481188
105PLK10.11688419
106PRKCQ0.10628731
107CDK120.09902631
108CSNK1D0.09715604
109CDK150.08911057
110FER0.08685718
111BLK0.08220848
112PRKACA0.07884163
113RPS6KA10.07337048
114GSK3B0.07179780
115CDK180.06439958
116CDK60.06163556
117TAF10.05543720
118CDK11A0.05384608
119BRSK10.05195701
120CSNK2A10.05114075
121MAPK90.04274745
122PRKG20.04110217
123STK100.03982260
124CDK20.03794943
125MINK10.03647340
126CDK10.03151200
127STK110.03091526
128PRKG10.03073530
129PKN10.03059669
130CSF1R0.03005386
131CAMK2A0.02647122
132PRKACG0.02463512
133CDK140.02454482
134BRAF0.01836037
135MAPK80.01731907
136MARK30.01642098
137PRKCB0.01452582
138CSNK2A20.01450338
139WNK30.01423695
140ZAP700.00558905
141PAK60.00523042
142CDK40.00419678
143MAP3K4-0.0250854
144PRKACB-0.0221690
145RPS6KA3-0.0179955
146MAP3K1-0.0169886
147PRKDC-0.0128976
148CLK1-0.0119801
149PRKCA-0.0113700
150MAP3K5-0.0109386
151RIPK1-0.0082081
152PRKCD-0.0067829
153PIM1-0.0013867
154EGFR-0.0010437

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.61781600
2Fatty acid biosynthesis_Homo sapiens_hsa000614.55328810
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.47556278
4Olfactory transduction_Homo sapiens_hsa047403.87217516
5Vitamin B6 metabolism_Homo sapiens_hsa007503.62202336
6Pyruvate metabolism_Homo sapiens_hsa006203.49773639
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90050017
8Linoleic acid metabolism_Homo sapiens_hsa005912.78097477
9Propanoate metabolism_Homo sapiens_hsa006402.74661452
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66821573
11Glucagon signaling pathway_Homo sapiens_hsa049222.56199660
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55456441
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37183749
14Butanoate metabolism_Homo sapiens_hsa006502.19176176
15Basal transcription factors_Homo sapiens_hsa030222.09782817
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08685522
17Glycerolipid metabolism_Homo sapiens_hsa005612.05254256
18Selenocompound metabolism_Homo sapiens_hsa004502.02652616
19PPAR signaling pathway_Homo sapiens_hsa033201.97178836
20Dorso-ventral axis formation_Homo sapiens_hsa043201.77562865
21Oocyte meiosis_Homo sapiens_hsa041141.71275473
22Pentose phosphate pathway_Homo sapiens_hsa000301.67217312
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66433564
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.66053121
25Fructose and mannose metabolism_Homo sapiens_hsa000511.62903346
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.58839918
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57519041
28Phenylalanine metabolism_Homo sapiens_hsa003601.56165218
29Amphetamine addiction_Homo sapiens_hsa050311.52053226
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48032051
31Mineral absorption_Homo sapiens_hsa049781.44884890
32Fatty acid metabolism_Homo sapiens_hsa012121.43322183
33Fatty acid degradation_Homo sapiens_hsa000711.42074564
34Carbon metabolism_Homo sapiens_hsa012001.37907253
35Type I diabetes mellitus_Homo sapiens_hsa049401.36524393
36Fat digestion and absorption_Homo sapiens_hsa049751.33485729
37Fanconi anemia pathway_Homo sapiens_hsa034601.32147935
38Cardiac muscle contraction_Homo sapiens_hsa042601.27626620
39Ether lipid metabolism_Homo sapiens_hsa005651.27118832
40Phototransduction_Homo sapiens_hsa047441.22466243
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.21950300
42Allograft rejection_Homo sapiens_hsa053301.21066242
43Autoimmune thyroid disease_Homo sapiens_hsa053201.20394758
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13643873
45Renin secretion_Homo sapiens_hsa049241.13629566
46Antigen processing and presentation_Homo sapiens_hsa046121.13001065
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12625411
48mRNA surveillance pathway_Homo sapiens_hsa030151.09455774
49Graft-versus-host disease_Homo sapiens_hsa053321.08778821
50Huntingtons disease_Homo sapiens_hsa050161.04299228
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98947384
52RNA transport_Homo sapiens_hsa030130.97950894
53Arginine biosynthesis_Homo sapiens_hsa002200.95038267
54Purine metabolism_Homo sapiens_hsa002300.94090805
55Morphine addiction_Homo sapiens_hsa050320.91541438
56Glutathione metabolism_Homo sapiens_hsa004800.90580385
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.88794677
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88781612
59Biosynthesis of amino acids_Homo sapiens_hsa012300.88618955
60Arginine and proline metabolism_Homo sapiens_hsa003300.87355293
61Viral myocarditis_Homo sapiens_hsa054160.86049737
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.84245825
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82562457
64Nicotine addiction_Homo sapiens_hsa050330.81987005
65Hedgehog signaling pathway_Homo sapiens_hsa043400.81375858
66Insulin secretion_Homo sapiens_hsa049110.80298157
67Collecting duct acid secretion_Homo sapiens_hsa049660.78471126
68Influenza A_Homo sapiens_hsa051640.77402592
69Estrogen signaling pathway_Homo sapiens_hsa049150.75118101
70Long-term potentiation_Homo sapiens_hsa047200.75033037
71Bile secretion_Homo sapiens_hsa049760.74850961
72Thyroid hormone synthesis_Homo sapiens_hsa049180.73716510
73Glutamatergic synapse_Homo sapiens_hsa047240.73565337
74Tyrosine metabolism_Homo sapiens_hsa003500.69250843
75Chemical carcinogenesis_Homo sapiens_hsa052040.69032479
76Arachidonic acid metabolism_Homo sapiens_hsa005900.68756734
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67453003
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66518532
79Renin-angiotensin system_Homo sapiens_hsa046140.64758978
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.60055116
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59139915
82ABC transporters_Homo sapiens_hsa020100.58336752
83Legionellosis_Homo sapiens_hsa051340.58162234
84Systemic lupus erythematosus_Homo sapiens_hsa053220.58059154
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57867580
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57305896
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.54720774
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54369547
89Calcium signaling pathway_Homo sapiens_hsa040200.54115575
90Serotonergic synapse_Homo sapiens_hsa047260.52122463
91Protein digestion and absorption_Homo sapiens_hsa049740.51296588
92Retinol metabolism_Homo sapiens_hsa008300.51245280
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51205086
94MAPK signaling pathway_Homo sapiens_hsa040100.48665435
95Endocytosis_Homo sapiens_hsa041440.48357699
96Salivary secretion_Homo sapiens_hsa049700.48341822
97Pancreatic secretion_Homo sapiens_hsa049720.47993096
98AMPK signaling pathway_Homo sapiens_hsa041520.47707680
99Inositol phosphate metabolism_Homo sapiens_hsa005620.47041052
100Nitrogen metabolism_Homo sapiens_hsa009100.46381674
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45936609
102Taste transduction_Homo sapiens_hsa047420.44631517
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43045216
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42777558
105Synaptic vesicle cycle_Homo sapiens_hsa047210.42496948
106Tight junction_Homo sapiens_hsa045300.41686309
107Gastric acid secretion_Homo sapiens_hsa049710.40464177
108Cholinergic synapse_Homo sapiens_hsa047250.38050095
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.37782100
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37380828
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35506629
112Metabolic pathways_Homo sapiens_hsa011000.34539544
113VEGF signaling pathway_Homo sapiens_hsa043700.34430809
114cAMP signaling pathway_Homo sapiens_hsa040240.34062444
115GABAergic synapse_Homo sapiens_hsa047270.33605137
116Acute myeloid leukemia_Homo sapiens_hsa052210.33596539
117ECM-receptor interaction_Homo sapiens_hsa045120.33509932
118Circadian entrainment_Homo sapiens_hsa047130.33231933
119Oxytocin signaling pathway_Homo sapiens_hsa049210.30957467
120Sulfur metabolism_Homo sapiens_hsa009200.30540899
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29394259
122Alcoholism_Homo sapiens_hsa050340.29072127
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27379242
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.26775112
125Cocaine addiction_Homo sapiens_hsa050300.24336709
126Prolactin signaling pathway_Homo sapiens_hsa049170.24149568
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23324214
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21868933
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19490496
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18409598
131N-Glycan biosynthesis_Homo sapiens_hsa005100.15493142
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14721014
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14312138
134Pyrimidine metabolism_Homo sapiens_hsa002400.14307069
135Insulin resistance_Homo sapiens_hsa049310.09605525
136Type II diabetes mellitus_Homo sapiens_hsa049300.09387246
137B cell receptor signaling pathway_Homo sapiens_hsa046620.08292712
138Basal cell carcinoma_Homo sapiens_hsa052170.08243633
139HIF-1 signaling pathway_Homo sapiens_hsa040660.08135824
140Viral carcinogenesis_Homo sapiens_hsa052030.07228117

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