FSCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)4.80016155
2hemidesmosome assembly (GO:0031581)4.31924568
3axonal fasciculation (GO:0007413)4.26018047
4protein retention in ER lumen (GO:0006621)4.11734837
5neuron projection extension involved in neuron projection guidance (GO:1902284)4.05985843
6axon extension involved in axon guidance (GO:0048846)4.05985843
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.00477839
8layer formation in cerebral cortex (GO:0021819)3.80317587
9positive regulation of cell size (GO:0045793)3.78725737
10semaphorin-plexin signaling pathway (GO:0071526)3.77230550
11protein localization to endosome (GO:0036010)3.75592041
12cell migration in hindbrain (GO:0021535)3.71865303
13paraxial mesoderm development (GO:0048339)3.71653048
14Golgi transport vesicle coating (GO:0048200)3.68664440
15COPI coating of Golgi vesicle (GO:0048205)3.68664440
16adherens junction assembly (GO:0034333)3.66872637
17dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.60758352
18basement membrane organization (GO:0071711)3.60310890
19pyrimidine nucleobase catabolic process (GO:0006208)3.58037282
20response to pheromone (GO:0019236)3.56681407
21cell-substrate junction assembly (GO:0007044)3.51763170
22neuron recognition (GO:0008038)3.47910910
23negative regulation of catenin import into nucleus (GO:0035414)3.43768933
24endodermal cell differentiation (GO:0035987)3.43281052
25convergent extension (GO:0060026)3.39717011
26Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.36566127
27hippo signaling (GO:0035329)3.26518281
28establishment of nucleus localization (GO:0040023)3.25780558
29cell-substrate adherens junction assembly (GO:0007045)3.23045564
30focal adhesion assembly (GO:0048041)3.23045564
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.22326059
32regulation of establishment of planar polarity (GO:0090175)3.17861968
33pre-miRNA processing (GO:0031054)3.17691430
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.17337989
35polarized epithelial cell differentiation (GO:0030859)3.16204876
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14937216
37negative regulation of chondrocyte differentiation (GO:0032331)3.14755277
38dendritic spine morphogenesis (GO:0060997)3.08174167
39lung-associated mesenchyme development (GO:0060484)3.06307444
40apoptotic process involved in morphogenesis (GO:0060561)2.99100537
41positive regulation of synapse maturation (GO:0090129)2.98191691
42peptidyl-arginine omega-N-methylation (GO:0035247)2.98008372
43vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96086598
44skin morphogenesis (GO:0043589)2.95575178
45substrate-independent telencephalic tangential migration (GO:0021826)2.94838022
46substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.94838022
47establishment of apical/basal cell polarity (GO:0035089)2.92388352
48embryonic foregut morphogenesis (GO:0048617)2.91063352
49activation of MAPKKK activity (GO:0000185)2.89295069
50neural tube development (GO:0021915)2.86361214
51epithelial cell-cell adhesion (GO:0090136)2.86324116
52stress fiber assembly (GO:0043149)2.85519635
53establishment of monopolar cell polarity (GO:0061162)2.85132101
54establishment or maintenance of monopolar cell polarity (GO:0061339)2.85132101
55axon extension (GO:0048675)2.81633951
56DNA unwinding involved in DNA replication (GO:0006268)2.81139829
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79885148
58response to prostaglandin E (GO:0034695)2.78896711
59peptidyl-arginine N-methylation (GO:0035246)2.78819005
60peptidyl-arginine methylation (GO:0018216)2.78819005
61negative regulation of axon guidance (GO:1902668)2.77453894
62regulation of chemokine-mediated signaling pathway (GO:0070099)2.75609428
63blood vessel endothelial cell migration (GO:0043534)2.75414573
64positive regulation of pseudopodium assembly (GO:0031274)2.73545347
65establishment of tissue polarity (GO:0007164)2.72024374
66establishment of planar polarity (GO:0001736)2.72024374
67vascular endothelial growth factor signaling pathway (GO:0038084)2.71536738
68regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71135006
69negative regulation of microtubule polymerization (GO:0031115)2.70700826
70positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70299763
71central nervous system projection neuron axonogenesis (GO:0021952)2.69631329
72neuronal ion channel clustering (GO:0045161)2.67749335
73activation of Rac GTPase activity (GO:0032863)2.65173076
74cell adhesion mediated by integrin (GO:0033627)2.65152149
75notochord development (GO:0030903)2.65098197
76cell migration involved in heart development (GO:0060973)2.64532715
77positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.61738879
78endothelial cell morphogenesis (GO:0001886)2.59372529
79regulation of gene silencing by RNA (GO:0060966)2.59316949
80regulation of posttranscriptional gene silencing (GO:0060147)2.59316949
81regulation of gene silencing by miRNA (GO:0060964)2.59316949
82positive regulation of filopodium assembly (GO:0051491)2.58596646
83Notch signaling involved in heart development (GO:0061314)2.58523061
84non-canonical Wnt signaling pathway (GO:0035567)2.58442871
85cell migration involved in sprouting angiogenesis (GO:0002042)2.57019569
86growth hormone receptor signaling pathway (GO:0060396)2.56752860
87neuron projection extension (GO:1990138)2.56327660
88negative regulation of oligodendrocyte differentiation (GO:0048715)2.53214203
89central nervous system myelination (GO:0022010)2.52019005
90axon ensheathment in central nervous system (GO:0032291)2.52019005
91negative chemotaxis (GO:0050919)2.51868833
92regulation of NFAT protein import into nucleus (GO:0051532)2.51736029
93NLS-bearing protein import into nucleus (GO:0006607)2.50880498
94heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.48848175
95barbed-end actin filament capping (GO:0051016)2.48728376
96forebrain neuron differentiation (GO:0021879)2.48177455
97protein complex localization (GO:0031503)2.48020238
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46118510
99positive regulation of axon extension (GO:0045773)2.45921970
100trophoblast giant cell differentiation (GO:0060707)2.45843611
101cellular protein complex localization (GO:0034629)2.45749712
102lens fiber cell development (GO:0070307)2.45709754
103regulation of hippo signaling (GO:0035330)2.45607426
104collagen metabolic process (GO:0032963)2.45494224
105regulation of early endosome to late endosome transport (GO:2000641)2.45218165
106negative regulation of cell size (GO:0045792)2.44280898
107cellular response to prostaglandin stimulus (GO:0071379)2.44188781
108ganglion development (GO:0061548)2.43768960
109retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43174310
110histone arginine methylation (GO:0034969)2.42906142
111regulation of translational fidelity (GO:0006450)2.42473436
112atrioventricular valve morphogenesis (GO:0003181)2.41967053
113positive regulation of axonogenesis (GO:0050772)2.41832632
114positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41271282
115regulation of integrin activation (GO:0033623)2.40943421
116cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40488056
117nucleobase catabolic process (GO:0046113)2.40267296
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.39695700
119astrocyte differentiation (GO:0048708)2.39488029
120negative regulation of axon extension involved in axon guidance (GO:0048843)2.39228664
121substrate-dependent cell migration (GO:0006929)2.39152145
122establishment or maintenance of bipolar cell polarity (GO:0061245)2.38988514
123establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38988514
124bone trabecula formation (GO:0060346)2.38787888
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37981291
126cell surface receptor signaling pathway involved in heart development (GO:0061311)2.36859786
127negative regulation of cell fate specification (GO:0009996)2.36274123
128collagen catabolic process (GO:0030574)2.35741925
129cortical actin cytoskeleton organization (GO:0030866)2.35658034
130positive regulation of dendrite morphogenesis (GO:0050775)2.34444850
131neuronal stem cell maintenance (GO:0097150)2.33292543
132negative regulation of JAK-STAT cascade (GO:0046426)2.32931565
133collagen fibril organization (GO:0030199)2.32579803
134establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.31979857
135eye morphogenesis (GO:0048592)2.31956069
136adherens junction organization (GO:0034332)2.31201302
137epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.30865723
138skeletal muscle organ development (GO:0060538)2.30308071
139branching involved in salivary gland morphogenesis (GO:0060445)2.29444307
140protein maturation by protein folding (GO:0022417)2.29352223
141regulation of axon guidance (GO:1902667)2.28943951
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.28867821
143heterochromatin organization (GO:0070828)2.28626599
144dendrite morphogenesis (GO:0048813)2.28336758
145response to prostaglandin (GO:0034694)2.28200085
146ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.28162694
147apoptotic process involved in development (GO:1902742)2.27432209
148G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.27411462
149cochlea morphogenesis (GO:0090103)2.26818544
150cell-cell junction maintenance (GO:0045217)2.26484141
151outer ear morphogenesis (GO:0042473)2.26390139
152lung epithelium development (GO:0060428)2.25359990
153ephrin receptor signaling pathway (GO:0048013)2.23747271
154nuclear pore complex assembly (GO:0051292)2.23344043
155nucleosome disassembly (GO:0006337)2.22813848
156protein-DNA complex disassembly (GO:0032986)2.22813848
157protein heterotrimerization (GO:0070208)2.22628043
158regulation of axon extension (GO:0030516)2.22064140
159synaptic vesicle maturation (GO:0016188)2.21703174
160regulation of pseudopodium assembly (GO:0031272)2.19697223
161cell proliferation involved in metanephros development (GO:0072203)2.18944207
162establishment of cell polarity (GO:0030010)2.18209772
163chondrocyte proliferation (GO:0035988)2.17728144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ZFP281_18757296_ChIP-ChIP_E14_Mouse3.14653383
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.09908657
3* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.03692134
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.92473423
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92226573
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86995236
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.83796729
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.67206944
9* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.65153272
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60728765
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.58509220
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34140342
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28554032
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25000236
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24593373
16* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.22096995
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18138732
18* KDM2B_26808549_Chip-Seq_K562_Human2.14989105
19* KDM2B_26808549_Chip-Seq_DND41_Human2.12647337
20* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01544387
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.94801931
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.93128797
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.93046158
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92486182
25* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91618511
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87595631
27RING1B_27294783_Chip-Seq_NPCs_Mouse1.86322476
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84860558
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84860558
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83801887
31* CLOCK_20551151_ChIP-Seq_293T_Human1.83047954
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.82085640
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79622836
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78594643
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74696654
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74696654
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74696654
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73371141
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72603873
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70493466
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68509173
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.67335785
43* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66438721
44E2F7_22180533_ChIP-Seq_HELA_Human1.63535325
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.62650961
46MYC_22102868_ChIP-Seq_BL_Human1.61212966
47* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.59963429
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.58624582
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57153895
50* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57058634
51* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54578770
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54547052
53* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54495667
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53397176
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.52827858
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52730394
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.52459322
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50998126
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50026346
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47664770
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45927412
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45312063
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45041625
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44742931
65* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43500826
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.41089581
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.40909048
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39841690
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38639378
70* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38299249
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36655633
72* TCF7_22412390_ChIP-Seq_EML_Mouse1.36544192
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.33472550
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33302926
75* LXR_22292898_ChIP-Seq_THP-1_Human1.32475179
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31186753
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.30708719
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30242220
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29845617
80ZNF263_19887448_ChIP-Seq_K562_Human1.29175021
81* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29050052
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28458995
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.28291483
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28064112
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26343504
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24647140
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.24205108
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23144464
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21267146
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20866000
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20312473
92CTCF_27219007_Chip-Seq_Bcells_Human1.19673912
93* SA1_27219007_Chip-Seq_ERYTHROID_Human1.18886696
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.18296077
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18025595
96* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17810121
97VDR_21846776_ChIP-Seq_THP-1_Human1.17046768
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16525870
99ATF3_27146783_Chip-Seq_COLON_Human1.16304172
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15938205
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14391962
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14036310
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.13786900
104CREB1_26743006_Chip-Seq_LNCaP_Human1.13721250
105P68_20966046_ChIP-Seq_HELA_Human1.12261542
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.11769063
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09380647
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.09143136
109* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08898637
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08860697
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08513465
112SMC4_20622854_ChIP-Seq_HELA_Human1.07066018
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06162690
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05653024
115* TP53_22127205_ChIP-Seq_IMR90_Human1.05624508
116PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05314694
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05156224
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04659843
119* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04477510
120* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04322091
121RACK7_27058665_Chip-Seq_MCF-7_Human1.04086900
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03659002
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03528000
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02698765
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01748747
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01726063
127DROSHA_22980978_ChIP-Seq_HELA_Human1.01646741
128* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01468332
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00723194
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99787181
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99007202
132POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98895780
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98713700
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98240405
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97633186
136* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97259001
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.96699599
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96410380
139* NCOR1_26117541_ChIP-Seq_K562_Human0.95852193
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.95500443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.80232523
2MP0010030_abnormal_orbit_morphology3.75865763
3MP0005623_abnormal_meninges_morphology3.33374541
4MP0002653_abnormal_ependyma_morphology3.30860481
5MP0000778_abnormal_nervous_system2.85844965
6MP0010368_abnormal_lymphatic_system2.81319096
7MP0005423_abnormal_somatic_nervous2.57341596
8MP0004859_abnormal_synaptic_plasticity2.53866537
9MP0000569_abnormal_digit_pigmentation2.40468128
10MP0001346_abnormal_lacrimal_gland2.37957258
11MP0003283_abnormal_digestive_organ2.36454018
12MP0005076_abnormal_cell_differentiation2.33943705
13MP0003705_abnormal_hypodermis_morpholog2.27436656
14MP0003122_maternal_imprinting2.26523226
15MP0002254_reproductive_system_inflammat2.15708425
16MP0005409_darkened_coat_color2.08313038
17MP0003091_abnormal_cell_migration1.99213299
18MP0000537_abnormal_urethra_morphology1.98947183
19MP0000579_abnormal_nail_morphology1.96773550
20MP0003279_aneurysm1.89564083
21MP0009053_abnormal_anal_canal1.89022207
22MP0000733_abnormal_muscle_development1.85482224
23MP0010352_gastrointestinal_tract_polyps1.83676293
24MP0008438_abnormal_cutaneous_collagen1.75249228
25MP0002138_abnormal_hepatobiliary_system1.72332701
26MP0003385_abnormal_body_wall1.71043550
27MP0003942_abnormal_urinary_system1.70618266
28MP0003941_abnormal_skin_development1.69068689
29MP0004858_abnormal_nervous_system1.66994946
30MP0002282_abnormal_trachea_morphology1.65684078
31MP0003119_abnormal_digestive_system1.64805527
32MP0000762_abnormal_tongue_morphology1.56968396
33MP0004133_heterotaxia1.54773791
34MP0000534_abnormal_ureter_morphology1.51203555
35MP0003861_abnormal_nervous_system1.50909126
36MP0001879_abnormal_lymphatic_vessel1.49374832
37MP0003115_abnormal_respiratory_system1.46655906
38MP0002060_abnormal_skin_morphology1.42061859
39MP0003121_genomic_imprinting1.40095613
40MP0004510_myositis1.39877699
41MP0003880_abnormal_central_pattern1.36803804
42MP0003329_amyloid_beta_deposits1.35718566
43MP0002932_abnormal_joint_morphology1.34198444
44MP0002163_abnormal_gland_morphology1.34058010
45MP0003453_abnormal_keratinocyte_physiol1.32991832
46MP0001958_emphysema1.32288631
47MP0000049_abnormal_middle_ear1.31808993
48MP0000428_abnormal_craniofacial_morphol1.31118277
49MP0002249_abnormal_larynx_morphology1.30044920
50MP0000955_abnormal_spinal_cord1.29441643
51MP0002184_abnormal_innervation1.28939617
52MP0002751_abnormal_autonomic_nervous1.26908804
53MP0005023_abnormal_wound_healing1.26506979
54MP0002877_abnormal_melanocyte_morpholog1.23953127
55MP0003890_abnormal_embryonic-extraembry1.23264092
56MP0010234_abnormal_vibrissa_follicle1.22940638
57MP0000003_abnormal_adipose_tissue1.22910520
58MP0004811_abnormal_neuron_physiology1.22426892
59MP0004233_abnormal_muscle_weight1.20350933
60MP0003755_abnormal_palate_morphology1.18618940
61MP0002084_abnormal_developmental_patter1.17891168
62MP0002234_abnormal_pharynx_morphology1.17099900
63MP0001730_embryonic_growth_arrest1.16972535
64MP0008789_abnormal_olfactory_epithelium1.16065839
65MP0005501_abnormal_skin_physiology1.14755774
66MP0003937_abnormal_limbs/digits/tail_de1.13784055
67MP0005248_abnormal_Harderian_gland1.13704685
68MP0002116_abnormal_craniofacial_bone1.12102971
69MP0000678_abnormal_parathyroid_gland1.10344029
70MP0002085_abnormal_embryonic_tissue1.10020364
71MP0001299_abnormal_eye_distance/1.08021304
72MP0002233_abnormal_nose_morphology1.07523596
73MP0005503_abnormal_tendon_morphology1.06659686
74MP0009672_abnormal_birth_weight1.06165125
75MP0005499_abnormal_olfactory_system1.05738599
76MP0005394_taste/olfaction_phenotype1.05738599
77MP0003566_abnormal_cell_adhesion1.04857401
78MP0002152_abnormal_brain_morphology1.04847065
79MP0008932_abnormal_embryonic_tissue1.04818542
80MP0005197_abnormal_uvea_morphology1.04605634
81MP0004197_abnormal_fetal_growth/weight/1.04501725
82MP0000751_myopathy1.04190221
83MP0008961_abnormal_basal_metabolism1.03832949
84MP0000350_abnormal_cell_proliferation1.03151537
85MP0002796_impaired_skin_barrier1.02599371
86MP0004272_abnormal_basement_membrane0.98573714
87MP0005508_abnormal_skeleton_morphology0.97483848
88MP0002081_perinatal_lethality0.97464276
89MP0009384_cardiac_valve_regurgitation0.96943284
90MP0003935_abnormal_craniofacial_develop0.96930266
91MP0003635_abnormal_synaptic_transmissio0.95594228
92MP0002697_abnormal_eye_size0.94893032
93MP0001293_anophthalmia0.94176557
94MP0000013_abnormal_adipose_tissue0.93872973
95MP0002063_abnormal_learning/memory/cond0.93363732
96MP0003634_abnormal_glial_cell0.92835123
97MP0002092_abnormal_eye_morphology0.92261088
98MP0003123_paternal_imprinting0.91848272
99MP0009250_abnormal_appendicular_skeleto0.90500335
100MP0000767_abnormal_smooth_muscle0.89906951
101MP0002896_abnormal_bone_mineralization0.89441733
102MP0005257_abnormal_intraocular_pressure0.88985165
103MP0002111_abnormal_tail_morphology0.88707466
104MP0003938_abnormal_ear_development0.88642200
105MP0001849_ear_inflammation0.88260852
106MP0005187_abnormal_penis_morphology0.88047983
107MP0003111_abnormal_nucleus_morphology0.87629687
108MP0002882_abnormal_neuron_morphology0.87113039
109MP0002277_abnormal_respiratory_mucosa0.86774137
110MP0003984_embryonic_growth_retardation0.85279917
111MP0009278_abnormal_bone_marrow0.85031290
112MP0002080_prenatal_lethality0.84342972
113MP0001915_intracranial_hemorrhage0.84321795
114MP0001614_abnormal_blood_vessel0.83957782
115MP0004185_abnormal_adipocyte_glucose0.83434800
116MP0002086_abnormal_extraembryonic_tissu0.83236758
117MP0002925_abnormal_cardiovascular_devel0.81741056
118MP0002102_abnormal_ear_morphology0.81340672
119MP0004134_abnormal_chest_morphology0.80525906
120MP0002089_abnormal_postnatal_growth/wei0.79742525
121MP0000467_abnormal_esophagus_morphology0.79155359
122MP0002822_catalepsy0.78858604
123MP0005193_abnormal_anterior_eye0.78721157
124MP0002088_abnormal_embryonic_growth/wei0.77048030
125MP0003300_gastrointestinal_ulcer0.76692459
126MP0005367_renal/urinary_system_phenotyp0.76585053
127MP0000516_abnormal_urinary_system0.76585053
128MP0000759_abnormal_skeletal_muscle0.76216633
129MP0000750_abnormal_muscle_regeneration0.75340023
130MP0005380_embryogenesis_phenotype0.74809468
131MP0001672_abnormal_embryogenesis/_devel0.74809468
132MP0000432_abnormal_head_morphology0.74586666
133MP0004270_analgesia0.74398947
134MP0005275_abnormal_skin_tensile0.74280090
135MP0008770_decreased_survivor_rate0.73938525
136MP0003315_abnormal_perineum_morphology0.72354822
137MP0008007_abnormal_cellular_replicative0.72121091
138MP0001697_abnormal_embryo_size0.72107564
139MP0000566_synostosis0.71983499

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.54107995
2Protrusio acetabuli (HP:0003179)3.45359661
3Atrophic scars (HP:0001075)3.37820547
4Renal duplication (HP:0000075)3.12550971
5Fragile skin (HP:0001030)3.03808087
6Short 4th metacarpal (HP:0010044)3.00694575
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00694575
8Cortical dysplasia (HP:0002539)2.96768862
9Wrist flexion contracture (HP:0001239)2.95720290
10Ulnar bowing (HP:0003031)2.89493487
11Hyperacusis (HP:0010780)2.88692090
12Spinal rigidity (HP:0003306)2.83419883
13Disproportionate tall stature (HP:0001519)2.79543436
14Peritonitis (HP:0002586)2.77872530
15Premature rupture of membranes (HP:0001788)2.74810554
16Cerebral aneurysm (HP:0004944)2.57600651
17Bladder diverticulum (HP:0000015)2.53681203
18Abnormality of the astrocytes (HP:0100707)2.39001714
19Astrocytoma (HP:0009592)2.39001714
20Pointed chin (HP:0000307)2.35203318
21High anterior hairline (HP:0009890)2.34070677
22Bowel diverticulosis (HP:0005222)2.33488174
23Natal tooth (HP:0000695)2.33433249
24Deviation of the hallux (HP:0010051)2.32421659
25Hallux valgus (HP:0001822)2.31348739
26Distal upper limb amyotrophy (HP:0007149)2.30427072
27Upper limb amyotrophy (HP:0009129)2.30427072
28Abnormality of the 4th metacarpal (HP:0010012)2.25838021
29Elfin facies (HP:0004428)2.24232511
30Genu recurvatum (HP:0002816)2.23037438
31Trigonocephaly (HP:0000243)2.20345380
32Increased connective tissue (HP:0009025)2.20069052
33Mitral regurgitation (HP:0001653)2.19734883
34Hypoventilation (HP:0002791)2.18656486
35Overriding aorta (HP:0002623)2.17362805
36Long palpebral fissure (HP:0000637)2.16796245
37Difficulty climbing stairs (HP:0003551)2.16448411
38Ependymoma (HP:0002888)2.14781024
39Flat cornea (HP:0007720)2.14745126
40Vascular tortuosity (HP:0004948)2.14354331
41Lower limb amyotrophy (HP:0007210)2.12729649
42Insomnia (HP:0100785)2.11656408
43Arterial tortuosity (HP:0005116)2.11528334
44Coronal craniosynostosis (HP:0004440)2.05533481
45Renovascular hypertension (HP:0100817)2.05185826
46Abnormality of the Achilles tendon (HP:0005109)2.03853440
47Thin ribs (HP:0000883)2.02879915
48Porencephaly (HP:0002132)2.02730223
49Hand muscle atrophy (HP:0009130)2.02455039
50Soft skin (HP:0000977)2.00560024
51Abnormality of the calcaneus (HP:0008364)2.00264865
52Synostosis of carpal bones (HP:0005048)2.00192006
53Broad metatarsal (HP:0001783)2.00049279
54Abnormality of dentin (HP:0010299)1.97955229
55Ankle contracture (HP:0006466)1.95206893
56Cervical subluxation (HP:0003308)1.95173705
57Failure to thrive in infancy (HP:0001531)1.93444337
58Neoplasm of the heart (HP:0100544)1.92798530
59Megalencephaly (HP:0001355)1.92190793
60Bronchomalacia (HP:0002780)1.91785661
61Short nail (HP:0001799)1.91291124
62Increased variability in muscle fiber diameter (HP:0003557)1.90397730
63Abnormality of oral frenula (HP:0000190)1.90386838
64Trismus (HP:0000211)1.89150910
65Dilatation of the ascending aorta (HP:0005111)1.88613346
66Elbow flexion contracture (HP:0002987)1.88470257
67Aortic dissection (HP:0002647)1.87116397
68Biconcave vertebral bodies (HP:0004586)1.86983943
69Aplasia involving bones of the upper limbs (HP:0009823)1.86436708
70Aplasia of the phalanges of the hand (HP:0009802)1.86436708
71Aplasia involving bones of the extremities (HP:0009825)1.86436708
72Amyotrophic lateral sclerosis (HP:0007354)1.85603722
73Vertebral arch anomaly (HP:0008438)1.84642028
74Megalocornea (HP:0000485)1.83631732
75Mitral valve prolapse (HP:0001634)1.83144694
76Broad face (HP:0000283)1.82018566
77Fragile nails (HP:0001808)1.79663816
78Joint laxity (HP:0001388)1.79623645
79Broad thumb (HP:0011304)1.79292222
80Vertebral compression fractures (HP:0002953)1.77824552
81Arnold-Chiari malformation (HP:0002308)1.77416487
82Nonimmune hydrops fetalis (HP:0001790)1.76304134
83Buphthalmos (HP:0000557)1.75625939
84Advanced eruption of teeth (HP:0006288)1.75458043
85Bowed forearm bones (HP:0003956)1.73994982
86Bowing of the arm (HP:0006488)1.73994982
87Obstructive sleep apnea (HP:0002870)1.73885148
88Distal lower limb amyotrophy (HP:0008944)1.73798045
89Mildly elevated creatine phosphokinase (HP:0008180)1.73415568
90Abnormality of the labia minora (HP:0012880)1.73305573
91Pseudobulbar signs (HP:0002200)1.73251578
92Wide anterior fontanel (HP:0000260)1.73085002
93Patellar dislocation (HP:0002999)1.72386039
94Neonatal short-limb short stature (HP:0008921)1.72349859
95Hypercalcemia (HP:0003072)1.69418303
96Abnormality of the peritoneum (HP:0002585)1.68749403
97Protruding ear (HP:0000411)1.68535467
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.68029819
99Neurofibrillary tangles (HP:0002185)1.67309632
100Shoulder girdle muscle weakness (HP:0003547)1.67101477
101Cerebral inclusion bodies (HP:0100314)1.66915308
102Premature skin wrinkling (HP:0100678)1.66620645
103Abnormality of the lower motor neuron (HP:0002366)1.65825811
104Vertebral fusion (HP:0002948)1.65718239
105Glioma (HP:0009733)1.65377511
106Abnormal number of incisors (HP:0011064)1.65247124
107Persistence of primary teeth (HP:0006335)1.64642833
108Increased nuchal translucency (HP:0010880)1.64589274
109Ectopia lentis (HP:0001083)1.63993388
110Fibroma (HP:0010614)1.63401062
111Heterotopia (HP:0002282)1.62906442
112Adducted thumb (HP:0001181)1.62843833
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.62582214
114Lymphangioma (HP:0100764)1.62499324
115Abnormality of skeletal muscle fiber size (HP:0012084)1.62479150
116Hammertoe (HP:0001765)1.62064185
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.61893345
118Ulnar deviation of finger (HP:0009465)1.61515486
119Lumbar hyperlordosis (HP:0002938)1.60544573
120Vitreoretinal degeneration (HP:0000655)1.60371018
121Pelvic girdle muscle weakness (HP:0003749)1.59976503
122Overgrowth (HP:0001548)1.59440342
123Midface retrusion (HP:0011800)1.58815601
124Thin bony cortex (HP:0002753)1.58786997
125Fibrous tissue neoplasm (HP:0012316)1.58258114
126Abnormality of the upper arm (HP:0001454)1.57528962
127Abnormality of the diencephalon (HP:0010662)1.56215547
128Wormian bones (HP:0002645)1.55423513
129Spina bifida occulta (HP:0003298)1.54624551
130Camptodactyly of toe (HP:0001836)1.54123863
131Fused cervical vertebrae (HP:0002949)1.53734871
132Carpal synostosis (HP:0009702)1.52417955
133Achilles tendon contracture (HP:0001771)1.51516511
134Absent hand (HP:0004050)1.50665269
135Preaxial foot polydactyly (HP:0001841)1.50427855
136Selective tooth agenesis (HP:0001592)1.50231892
137Supranuclear gaze palsy (HP:0000605)1.49587646
138Tarsal synostosis (HP:0008368)1.49096962
139Radial bowing (HP:0002986)1.49046025
140Adactyly (HP:0009776)1.47806754
141Skull defect (HP:0001362)1.47495830
142Abnormality of the humerus (HP:0003063)1.47185338
143Neoplasm of the oral cavity (HP:0100649)1.46758989
144Abnormality of the aortic arch (HP:0012303)1.46025367
145Bilateral microphthalmos (HP:0007633)1.45602076
146Congenital glaucoma (HP:0001087)1.44997164
147Broad phalanges of the hand (HP:0009768)1.44441723
148Amaurosis fugax (HP:0100576)1.43716723
149Abnormal sex determination (HP:0012244)1.43524944
150Sex reversal (HP:0012245)1.43524944
151Blue sclerae (HP:0000592)1.43498069
152Hyperextensible skin (HP:0000974)1.43259005
153Spinal muscular atrophy (HP:0007269)1.43131106
154Ankyloglossia (HP:0010296)1.41958055
155Turricephaly (HP:0000262)1.41858911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.27594249
2EPHA33.19515925
3KSR13.16051882
4SMG12.98757310
5MARK12.82372296
6ICK2.59875462
7LATS22.42725685
8MAP3K102.40754545
9MAP3K92.32826517
10PAK62.30811418
11SIK32.26945024
12PRPF4B2.03576633
13TESK21.98417560
14MAP3K131.97559604
15TRIB31.88769973
16ARAF1.86687396
17TYRO31.86502774
18BCR1.85936022
19NME21.80734568
20TIE11.78188040
21DDR21.72306641
22IRAK31.70461093
23RIPK11.65280131
24PDGFRA1.63917960
25LIMK11.62326418
26CDK121.61752394
27DYRK21.60711424
28EPHA21.59219859
29KDR1.57759841
30PAK31.52585163
31KSR21.52343190
32NTRK21.50248029
33CHUK1.46669178
34TESK11.46591260
35BMX1.42446732
36UHMK11.41659732
37NTRK11.38486539
38MINK11.38168730
39MET1.36639403
40NEK11.32155215
41MAP3K141.32073328
42ERBB21.28976621
43PKN11.27859988
44TTN1.27062611
45PAK41.17913807
46ALK1.16488849
47PIM21.14900537
48BRAF1.10142040
49LMTK21.08798744
50PTK21.05192590
51BRD41.05150098
52IKBKB1.05018555
53PTK61.04120285
54EPHB11.03389186
55MTOR1.02313412
56RET1.02160754
57SIK21.01274855
58CDK180.99951237
59PAK20.98144891
60PRKD30.97273874
61CDK140.92512530
62TAOK20.92230716
63ERBB40.90243697
64CDK150.90028039
65ROCK20.89910544
66FGFR40.88016036
67PKN20.86747493
68TBK10.85355382
69IRAK20.84896735
70MST1R0.84368224
71PRKCZ0.81356570
72FGFR10.80175956
73CDK11A0.77956197
74FGFR20.75788310
75PAK10.75310603
76ROCK10.74023297
77MOS0.71560557
78RPS6KA10.71468020
79PRKD20.66786049
80ERN10.66559079
81AURKA0.66456798
82MARK20.66151713
83EEF2K0.64960497
84FER0.64682923
85SIK10.64225659
86CDK50.63108817
87PRKG20.60591971
88PDGFRB0.59217238
89DYRK1B0.59126234
90DYRK30.58598309
91IRAK10.58421782
92ILK0.57155508
93CDC42BPA0.56625521
94MAP3K110.55606019
95DMPK0.55092526
96TYK20.54993454
97FLT30.54342500
98SCYL20.54061560
99CDK70.53713470
100RPS6KA20.53633765
101FGFR30.53155934
102TGFBR10.52992129
103ERBB30.51696037
104JAK30.51126065
105LATS10.50576546
106AKT20.48845969
107CDK90.48595188
108DAPK30.48100036
109AKT10.47755544
110TSSK60.47472241
111RPS6KC10.47358717
112RPS6KL10.47358717
113CLK10.46987663
114STK110.45298158
115JAK10.42906444
116MAP3K80.42648355
117NEK20.42091253
118BRSK10.41552925
119MELK0.41309451
120MAPK90.40951387
121CAMKK10.40246291
122MAPKAPK20.40140117
123CSF1R0.37702147
124CDK40.37428239
125CAMK1D0.36335880
126CHEK10.35809374
127MAP3K60.34809282
128BUB10.34610521
129CHEK20.34358083
130SRC0.33233880
131PRKAA20.33101698
132PASK0.32796887
133CAMK1G0.32141376
134TTK0.31526302
135CDC70.31092954
136PRKCH0.30691948
137LRRK20.29786737
138ABL20.29602482
139MAPK100.27678106
140CDK20.25843228

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.34507083
2Basal cell carcinoma_Homo sapiens_hsa052172.04414522
3Hippo signaling pathway_Homo sapiens_hsa043901.92973406
4Notch signaling pathway_Homo sapiens_hsa043301.88366025
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76521862
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76498685
7Chronic myeloid leukemia_Homo sapiens_hsa052201.72492715
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69061370
9Hedgehog signaling pathway_Homo sapiens_hsa043401.67626295
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54969529
11* MicroRNAs in cancer_Homo sapiens_hsa052061.54362101
12Colorectal cancer_Homo sapiens_hsa052101.47332572
13Viral myocarditis_Homo sapiens_hsa054161.45602786
14Thyroid cancer_Homo sapiens_hsa052161.44203694
15Small cell lung cancer_Homo sapiens_hsa052221.41990544
16Proteoglycans in cancer_Homo sapiens_hsa052051.38608771
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38416427
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.37903305
19Endometrial cancer_Homo sapiens_hsa052131.33454212
20Glioma_Homo sapiens_hsa052141.33414993
21Biosynthesis of amino acids_Homo sapiens_hsa012301.29663473
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29394262
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28097059
24ErbB signaling pathway_Homo sapiens_hsa040121.27484671
25Renal cell carcinoma_Homo sapiens_hsa052111.27432243
26Apoptosis_Homo sapiens_hsa042101.25903622
27Gap junction_Homo sapiens_hsa045401.23881945
28Pentose phosphate pathway_Homo sapiens_hsa000301.22596322
29Shigellosis_Homo sapiens_hsa051311.21651439
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21546712
31Bladder cancer_Homo sapiens_hsa052191.19846897
32Focal adhesion_Homo sapiens_hsa045101.17339657
33Adherens junction_Homo sapiens_hsa045201.16641306
34Alcoholism_Homo sapiens_hsa050341.15521064
35TNF signaling pathway_Homo sapiens_hsa046681.12035861
36Melanogenesis_Homo sapiens_hsa049161.11374418
37VEGF signaling pathway_Homo sapiens_hsa043701.10319273
38mTOR signaling pathway_Homo sapiens_hsa041501.10204957
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09971934
40Dilated cardiomyopathy_Homo sapiens_hsa054141.09687283
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09373721
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09309846
43Pancreatic cancer_Homo sapiens_hsa052121.08598216
44HTLV-I infection_Homo sapiens_hsa051661.06540856
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06242764
46Pathways in cancer_Homo sapiens_hsa052001.04284627
47Vibrio cholerae infection_Homo sapiens_hsa051101.04095502
48p53 signaling pathway_Homo sapiens_hsa041151.02551919
49Estrogen signaling pathway_Homo sapiens_hsa049151.01428675
50Wnt signaling pathway_Homo sapiens_hsa043100.99476306
51Non-small cell lung cancer_Homo sapiens_hsa052230.98701559
52Toxoplasmosis_Homo sapiens_hsa051450.97992126
53MAPK signaling pathway_Homo sapiens_hsa040100.97862073
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97656931
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97268502
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97145302
57Chemokine signaling pathway_Homo sapiens_hsa040620.96570896
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96162964
59Dorso-ventral axis formation_Homo sapiens_hsa043200.93693651
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93573465
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92626014
62Galactose metabolism_Homo sapiens_hsa000520.91903313
63Viral carcinogenesis_Homo sapiens_hsa052030.91610338
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.91468581
65TGF-beta signaling pathway_Homo sapiens_hsa043500.89334227
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88554338
67Oocyte meiosis_Homo sapiens_hsa041140.88351663
68Epstein-Barr virus infection_Homo sapiens_hsa051690.88078420
69Prolactin signaling pathway_Homo sapiens_hsa049170.87855167
70Oxytocin signaling pathway_Homo sapiens_hsa049210.87420121
71Acute myeloid leukemia_Homo sapiens_hsa052210.87123676
72mRNA surveillance pathway_Homo sapiens_hsa030150.85608312
73Allograft rejection_Homo sapiens_hsa053300.83645720
74Tight junction_Homo sapiens_hsa045300.83579749
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.83234357
76GnRH signaling pathway_Homo sapiens_hsa049120.82866702
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82166140
78Protein digestion and absorption_Homo sapiens_hsa049740.81829418
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.81716117
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81361366
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80348988
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79651199
83Rap1 signaling pathway_Homo sapiens_hsa040150.79069369
84Cholinergic synapse_Homo sapiens_hsa047250.77389925
85Prion diseases_Homo sapiens_hsa050200.77362448
86Hepatitis B_Homo sapiens_hsa051610.76726459
87Insulin signaling pathway_Homo sapiens_hsa049100.76258616
88Endocytosis_Homo sapiens_hsa041440.76163418
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.75358355
90Cell cycle_Homo sapiens_hsa041100.74761485
91Leishmaniasis_Homo sapiens_hsa051400.74019100
92ECM-receptor interaction_Homo sapiens_hsa045120.72982260
93Prostate cancer_Homo sapiens_hsa052150.70804576
94Ras signaling pathway_Homo sapiens_hsa040140.70308394
95Systemic lupus erythematosus_Homo sapiens_hsa053220.70299795
96Long-term potentiation_Homo sapiens_hsa047200.70135207
97Melanoma_Homo sapiens_hsa052180.69717195
98Amoebiasis_Homo sapiens_hsa051460.69461483
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69411540
100Circadian entrainment_Homo sapiens_hsa047130.68828967
101Type II diabetes mellitus_Homo sapiens_hsa049300.66248641
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66112594
103Salmonella infection_Homo sapiens_hsa051320.65818740
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65256081
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65168324
106Synaptic vesicle cycle_Homo sapiens_hsa047210.65126744
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64805773
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.63756239
109Fructose and mannose metabolism_Homo sapiens_hsa000510.63326912
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63214533
111Spliceosome_Homo sapiens_hsa030400.63142083
112Osteoclast differentiation_Homo sapiens_hsa043800.63105372
113Glutamatergic synapse_Homo sapiens_hsa047240.62744684
114GABAergic synapse_Homo sapiens_hsa047270.61611898
115Cocaine addiction_Homo sapiens_hsa050300.61608295
116HIF-1 signaling pathway_Homo sapiens_hsa040660.61227846
117Dopaminergic synapse_Homo sapiens_hsa047280.61043336
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.60836433
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60419901
120Sulfur relay system_Homo sapiens_hsa041220.57451158
121Vitamin B6 metabolism_Homo sapiens_hsa007500.55524385
122DNA replication_Homo sapiens_hsa030300.55385824
123Lysine degradation_Homo sapiens_hsa003100.54658111
124Other glycan degradation_Homo sapiens_hsa005110.54571628
125AMPK signaling pathway_Homo sapiens_hsa041520.53710878
126Carbon metabolism_Homo sapiens_hsa012000.50969489
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47800656
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47075878

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »