ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.39296317
2	fusion of sperm to egg plasma membrane (GO:0007342)	9.37019103
3	sperm motility (GO:0030317)	9.16747091
4	chromosome condensation (GO:0030261)	8.56668805
5	microtubule depolymerization (GO:0007019)	8.03755316
6	DNA packaging (GO:0006323)	7.93080815
7	single strand break repair (GO:0000012)	7.34354248
8	plasma membrane fusion (GO:0045026)	7.04633521
9	sperm capacitation (GO:0048240)	6.80654747
10	microtubule polymerization or depolymerization (GO:0031109)	6.56321131
11	sexual reproduction (GO:0019953)	6.43469977
12	cellular ketone body metabolic process (GO:0046950)	6.39745333
13	negative regulation of inclusion body assembly (GO:0090084)	6.10250784
14	sperm-egg recognition (GO:0035036)	6.05612295
15	spermatid development (GO:0007286)	6.04669390
16	binding of sperm to zona pellucida (GO:0007339)	5.96975667
17	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.90149233
18	ketone body metabolic process (GO:1902224)	5.65272000
19	calcium ion-dependent exocytosis (GO:0017156)	5.61953225
20	protein polyglutamylation (GO:0018095)	5.54789581
21	reproduction (GO:0000003)	5.48802854
22	multicellular organism reproduction (GO:0032504)	5.40947292
23	axonemal dynein complex assembly (GO:0070286)	5.35265377
24	centriole replication (GO:0007099)	5.10696171
25	rRNA methylation (GO:0031167)	4.89831852
26	cell-cell recognition (GO:0009988)	4.86297848
27	spermatogenesis (GO:0007283)	4.78231780
28	male gamete generation (GO:0048232)	4.76397286
29	chromatin silencing (GO:0006342)	4.72088883
30	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.56039738
31	gamete generation (GO:0007276)	4.33036635
32	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.27649241
33	protein targeting to Golgi (GO:0000042)	4.21854815
34	rRNA modification (GO:0000154)	4.19734052
35	positive regulation of Rab GTPase activity (GO:0032851)	4.04009351
36	regulation of Rab GTPase activity (GO:0032313)	4.04009351
37	phosphatidylethanolamine metabolic process (GO:0046337)	4.01786681
38	regulation of inclusion body assembly (GO:0090083)	4.01746983
39	centriole assembly (GO:0098534)	4.00455826
40	establishment of protein localization to Golgi (GO:0072600)	3.92277356
41	microtubule severing (GO:0051013)	3.91014261
42	cranial nerve morphogenesis (GO:0021602)	3.78850869
43	cell proliferation involved in metanephros development (GO:0072203)	3.77520946
44	protein-DNA complex disassembly (GO:0032986)	3.76135566
45	nucleosome disassembly (GO:0006337)	3.76135566
46	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.74165984
47	potassium ion export (GO:0071435)	3.72026340
48	nucleus organization (GO:0006997)	3.68997875
49	cilium or flagellum-dependent cell motility (GO:0001539)	3.68877282
50	regulation of transcription involved in cell fate commitment (GO:0060850)	3.68541198
51	single fertilization (GO:0007338)	3.63639119
52	urogenital system development (GO:0001655)	3.62375655
53	protein localization to Golgi apparatus (GO:0034067)	3.59334855
54	polyamine biosynthetic process (GO:0006596)	3.50975882
55	motile cilium assembly (GO:0044458)	3.48444455
56	glycerol ether metabolic process (GO:0006662)	3.44750928
57	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.42838964
58	positive regulation of skeletal muscle tissue development (GO:0048643)	3.42605372
59	multicellular organismal reproductive process (GO:0048609)	3.37940577
60	negative regulation of gene expression, epigenetic (GO:0045814)	3.37922839
61	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.37585023
62	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.37585023
63	positive regulation of gastrulation (GO:2000543)	3.37239232
64	regulation of centriole replication (GO:0046599)	3.35036029
65	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.31959671
66	cell differentiation involved in metanephros development (GO:0072202)	3.30485848
67	negative regulation of Rho protein signal transduction (GO:0035024)	3.30168517
68	cell wall macromolecule catabolic process (GO:0016998)	3.25326830
69	germ cell development (GO:0007281)	3.23073372
70	pattern specification involved in kidney development (GO:0061004)	3.15812702
71	ether metabolic process (GO:0018904)	3.14643954
72	epithelial cilium movement (GO:0003351)	3.14195680
73	protein depolymerization (GO:0051261)	3.06389245
74	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.04963619
75	NAD biosynthetic process (GO:0009435)	3.02850833
76	cell wall macromolecule metabolic process (GO:0044036)	3.00985058
77	coenzyme catabolic process (GO:0009109)	3.00656048
78	4-hydroxyproline metabolic process (GO:0019471)	2.99374235
79	RNA destabilization (GO:0050779)	2.98270390
80	fertilization (GO:0009566)	2.95825697
81	urinary tract smooth muscle contraction (GO:0014848)	2.86933228
82	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.82838302
83	musculoskeletal movement (GO:0050881)	2.81766024
84	multicellular organismal movement (GO:0050879)	2.81766024
85	peristalsis (GO:0030432)	2.78318120
86	establishment of tissue polarity (GO:0007164)	2.76280625
87	establishment of planar polarity (GO:0001736)	2.76280625
88	spinal cord motor neuron differentiation (GO:0021522)	2.76006513
89	regulation of cilium movement (GO:0003352)	2.75892009
90	cilium movement (GO:0003341)	2.75505415
91	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.73470193
92	retinoic acid receptor signaling pathway (GO:0048384)	2.70416226
93	sequestering of actin monomers (GO:0042989)	2.70341625
94	nucleosome organization (GO:0034728)	2.70275922
95	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.67854201
96	alanine transport (GO:0032328)	2.66322073
97	histone exchange (GO:0043486)	2.65044735
98	acrosome assembly (GO:0001675)	2.64824983
99	spermatid nucleus differentiation (GO:0007289)	11.5591332
100	acrosome reaction (GO:0007340)	10.9318403

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.59737959
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.82698519
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.69727276
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.20133218
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.13618101
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.83177569
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58877753
8	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.52045411
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52045411
10	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.19287985
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18167241
12	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.11986765
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.05562769
14	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.97657519
15	ERA_21632823_ChIP-Seq_H3396_Human	1.92003752
16	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.90974929
17	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.89895670
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.86355382
19	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.84944471
20	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.83792414
21	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.77267289
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.73010232
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69753586
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.69753586
25	BCL6_27268052_Chip-Seq_Bcells_Human	1.69063075
26	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.68335820
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64944340
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.63907940
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.62871104
30	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.61607832
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.56919345
32	RAC3_21632823_ChIP-Seq_H3396_Human	1.55967870
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55787405
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55488122
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53732368
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52167117
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.50713788
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.50590070
39	E2F1_20622854_ChIP-Seq_HELA_Human	1.50470303
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.50204722
41	BCOR_27268052_Chip-Seq_Bcells_Human	1.49536050
42	PHF8_20622854_ChIP-Seq_HELA_Human	1.49120882
43	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.48069377
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.44585782
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41591996
46	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.38464148
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37980921
48	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.35584965
49	P300_27268052_Chip-Seq_Bcells_Human	1.33630978
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.29644643
51	CTCF_20526341_ChIP-Seq_ESCs_Human	1.28479539
52	P68_20966046_ChIP-Seq_HELA_Human	1.28169033
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.25404714
54	LXR_22292898_ChIP-Seq_THP-1_Human	1.23245580
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22038720
56	VDR_22108803_ChIP-Seq_LS180_Human	1.19948074
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19072326
58	FUS_26573619_Chip-Seq_HEK293_Human	1.18813660
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18599091
60	OCT4_20526341_ChIP-Seq_ESCs_Human	1.17917088
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.17165264
62	DROSHA_22980978_ChIP-Seq_HELA_Human	1.16352785
63	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.15808468
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14854217
65	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.13704589
66	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.08904698
67	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08154333
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.07023560
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06044444
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05825723
71	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04304734
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02516439
73	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.01336421
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00494556
75	SA1_27219007_Chip-Seq_Bcells_Human	0.99975779
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99844135
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.99735223
78	AR_25329375_ChIP-Seq_VCAP_Human	0.99704491
79	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99077391
80	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.98803543
81	SMC4_20622854_ChIP-Seq_HELA_Human	0.98197864
82	TP63_22573176_ChIP-Seq_HFKS_Human	0.98043323
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97334876
84	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.96832191
85	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96664856
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96386386
87	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95288370
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95203526
89	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.93687718
90	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.93503319
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93095839
92	OCT4_19829295_ChIP-Seq_ESCs_Human	0.90834832
93	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.90422776
94	CEBPB_22108803_ChIP-Seq_LS180_Human	0.89583470
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88846796
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88846796
97	NCOR_22424771_ChIP-Seq_293T_Human	0.88646670
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88640919
99	NFYB_21822215_ChIP-Seq_K562_Human	0.88120832
100	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.87925283

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.13557024
2	MP0003878_abnormal_ear_physiology	5.63042042
3	MP0005377_hearing/vestibular/ear_phenot	5.63042042
4	MP0002822_catalepsy	4.46298588
5	MP0002102_abnormal_ear_morphology	3.51347070
6	MP0002234_abnormal_pharynx_morphology	3.10663719
7	MP0003698_abnormal_male_reproductive	2.94385270
8	MP0003011_delayed_dark_adaptation	2.65352258
9	MP0001348_abnormal_lacrimal_gland	2.63326119
10	MP0002249_abnormal_larynx_morphology	2.60757143
11	MP0009053_abnormal_anal_canal	2.56590010
12	MP0001485_abnormal_pinna_reflex	2.54276915
13	MP0005670_abnormal_white_adipose	2.50118384
14	MP0001929_abnormal_gametogenesis	2.49206028
15	MP0002282_abnormal_trachea_morphology	2.44025944
16	MP0002653_abnormal_ependyma_morphology	2.10062785
17	MP0003283_abnormal_digestive_organ	2.02726631
18	MP0005645_abnormal_hypothalamus_physiol	1.99126943
19	MP0000678_abnormal_parathyroid_gland	1.94356350
20	MP0000026_abnormal_inner_ear	1.84448066
21	MP0000049_abnormal_middle_ear	1.68743378
22	MP0002735_abnormal_chemical_nociception	1.66518774
23	MP0002161_abnormal_fertility/fecundity	1.64568866
24	MP0005623_abnormal_meninges_morphology	1.60176260
25	MP0003718_maternal_effect	1.50611886
26	MP0005084_abnormal_gallbladder_morpholo	1.49313364
27	MP0006292_abnormal_olfactory_placode	1.44413286
28	MP0009046_muscle_twitch	1.43155176
29	MP0004742_abnormal_vestibular_system	1.37800796
30	MP0001486_abnormal_startle_reflex	1.33105805
31	MP0005423_abnormal_somatic_nervous	1.28554067
32	MP0008789_abnormal_olfactory_epithelium	1.27930526
33	MP0005394_taste/olfaction_phenotype	1.27453046
34	MP0005499_abnormal_olfactory_system	1.27453046
35	MP0002132_abnormal_respiratory_system	1.26132951
36	MP0006276_abnormal_autonomic_nervous	1.25698940
37	MP0002638_abnormal_pupillary_reflex	1.23679884
38	MP0004510_myositis	1.20089261
39	MP0000534_abnormal_ureter_morphology	1.16849315
40	MP0003136_yellow_coat_color	1.15874011
41	MP0002210_abnormal_sex_determination	1.14991733
42	MP0008961_abnormal_basal_metabolism	1.13049648
43	MP0001963_abnormal_hearing_physiology	1.12797431
44	MP0001293_anophthalmia	1.10022414
45	MP0000566_synostosis	1.05621694
46	MP0000955_abnormal_spinal_cord	1.03927267
47	MP0002733_abnormal_thermal_nociception	1.02602255
48	MP0005253_abnormal_eye_physiology	1.02183558
49	MP0005551_abnormal_eye_electrophysiolog	1.01943148
50	MP0002938_white_spotting	0.99679865
51	MP0003938_abnormal_ear_development	0.97466573
52	MP0004859_abnormal_synaptic_plasticity	0.96407137
53	MP0003137_abnormal_impulse_conducting	0.93773347
54	MP0001145_abnormal_male_reproductive	0.93138120
55	MP0002557_abnormal_social/conspecific_i	0.89213124
56	MP0005379_endocrine/exocrine_gland_phen	0.87683038
57	MP0001529_abnormal_vocalization	0.87628250
58	MP0003077_abnormal_cell_cycle	0.86953605
59	MP0002928_abnormal_bile_duct	0.86915904
60	MP0001270_distended_abdomen	0.84170848
61	MP0000467_abnormal_esophagus_morphology	0.83271883
62	MP0002067_abnormal_sensory_capabilities	0.82986244
63	MP0000681_abnormal_thyroid_gland	0.82984614
64	MP0002752_abnormal_somatic_nervous	0.81476318
65	MP0002229_neurodegeneration	0.81309099
66	MP0000778_abnormal_nervous_system	0.80675112
67	MP0001765_abnormal_ion_homeostasis	0.78724191
68	MP0000653_abnormal_sex_gland	0.78524854
69	MP0003115_abnormal_respiratory_system	0.77962384
70	MP0000631_abnormal_neuroendocrine_gland	0.77942524
71	MP0002882_abnormal_neuron_morphology	0.76870253
72	MP0002751_abnormal_autonomic_nervous	0.75244386
73	MP0005391_vision/eye_phenotype	0.74853191
74	MP0001970_abnormal_pain_threshold	0.74114750
75	MP0009745_abnormal_behavioral_response	0.70364171
76	MP0002572_abnormal_emotion/affect_behav	0.68492917
77	MP0005451_abnormal_body_composition	0.68367809
78	MP0003646_muscle_fatigue	0.65540210
79	MP0004085_abnormal_heartbeat	0.65372880
80	MP0002697_abnormal_eye_size	0.65205633
81	MP0005083_abnormal_biliary_tract	0.64160310
82	MP0003755_abnormal_palate_morphology	0.63222513
83	MP0003119_abnormal_digestive_system	0.62922999
84	MP0004145_abnormal_muscle_electrophysio	0.62705963
85	MP0002233_abnormal_nose_morphology	0.59143969
86	MP0002272_abnormal_nervous_system	0.58988441
87	MP0003879_abnormal_hair_cell	0.58155520
88	MP0001968_abnormal_touch/_nociception	0.58001782
89	MP0001299_abnormal_eye_distance/	0.57377825
90	MP0003935_abnormal_craniofacial_develop	0.55996942
91	MP0001286_abnormal_eye_development	0.55612083
92	MP0001340_abnormal_eyelid_morphology	0.55394095
93	MP0002160_abnormal_reproductive_system	0.54238814
94	MP0005195_abnormal_posterior_eye	0.52547821
95	MP0004142_abnormal_muscle_tone	0.52243562
96	MP0002127_abnormal_cardiovascular_syste	0.52217765
97	MP0005595_abnormal_vascular_smooth	0.49449060
98	MP0002932_abnormal_joint_morphology	0.49022312
99	MP0003861_abnormal_nervous_system	0.48679307
100	MP0000470_abnormal_stomach_morphology	0.46707107

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bony spicule pigmentary retinopathy (HP:0007737)	5.64132264
2	Severe visual impairment (HP:0001141)	5.28349485
3	Attenuation of retinal blood vessels (HP:0007843)	5.07665679
4	Posterior subcapsular cataract (HP:0007787)	4.66650663
5	Abnormal ciliary motility (HP:0012262)	4.41518417
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.36469647
7	Absent/shortened dynein arms (HP:0200106)	4.36469647
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.98725400
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.96549208
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.96549208
11	Abnormal respiratory motile cilium physiology (HP:0012261)	3.68392740
12	Hypoplastic ischia (HP:0003175)	3.58318341
13	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.50571335
14	Intestinal atresia (HP:0011100)	3.35836770
15	Subcapsular cataract (HP:0000523)	3.29726238
16	Ulnar claw (HP:0001178)	3.24101906
17	Esophageal atresia (HP:0002032)	3.19361132
18	Scotoma (HP:0000575)	3.06677549
19	Nasal polyposis (HP:0100582)	3.00850939
20	Abnormality of the ischium (HP:0003174)	2.97745746
21	Chronic hepatic failure (HP:0100626)	2.96845539
22	Enlarged epiphyses (HP:0010580)	2.92478826
23	Chorioretinal atrophy (HP:0000533)	2.88281509
24	Facial shape deformation (HP:0011334)	2.83870905
25	Potter facies (HP:0002009)	2.83870905
26	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.83686852
27	Generalized aminoaciduria (HP:0002909)	2.79386510
28	Unilateral renal agenesis (HP:0000122)	2.77351407
29	Asymmetric septal hypertrophy (HP:0001670)	2.77174951
30	Flattened epiphyses (HP:0003071)	2.73335462
31	Infertility (HP:0000789)	2.70790797
32	Central scotoma (HP:0000603)	2.70625006
33	Insidious onset (HP:0003587)	2.70019151
34	Termporal pattern (HP:0011008)	2.70019151
35	Abnormality of macular pigmentation (HP:0008002)	2.66962297
36	Progressive sensorineural hearing impairment (HP:0000408)	2.65972468
37	Optic nerve hypoplasia (HP:0000609)	2.62996668
38	Maternal diabetes (HP:0009800)	2.59841869
39	Constricted visual fields (HP:0001133)	2.57807828
40	Optic disc pallor (HP:0000543)	2.55050597
41	Renal dysplasia (HP:0000110)	2.50928607
42	Type II diabetes mellitus (HP:0005978)	2.46611335
43	Abnormality of the aortic arch (HP:0012303)	2.43513495
44	Abnormality of the nasal mucosa (HP:0000433)	2.41094852
45	Bell-shaped thorax (HP:0001591)	2.36186404
46	Decreased central vision (HP:0007663)	2.35207970
47	Retinal dysplasia (HP:0007973)	2.35088533
48	Tubulointerstitial nephritis (HP:0001970)	2.33129830
49	Abnormality of the parathyroid morphology (HP:0011766)	2.31479848
50	Nephronophthisis (HP:0000090)	2.29775025
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.26681313
52	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.26619964
53	Bilateral microphthalmos (HP:0007633)	2.26205259
54	Median cleft lip (HP:0000161)	2.26128312
55	Upper limb muscle weakness (HP:0003484)	2.25257094
56	Gastrointestinal atresia (HP:0002589)	2.25076206
57	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.24077407
58	Absent epiphyses (HP:0010577)	2.24077407
59	Male infertility (HP:0003251)	2.22969477
60	Ventricular fibrillation (HP:0001663)	2.21951764
61	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.19391479
62	Stage 5 chronic kidney disease (HP:0003774)	2.15540528
63	Septo-optic dysplasia (HP:0100842)	2.15296805
64	Birth length less than 3rd percentile (HP:0003561)	2.14172140
65	Azoospermia (HP:0000027)	2.08874432
66	Photophobia (HP:0000613)	2.07991090
67	Muscle fiber atrophy (HP:0100295)	2.06373435
68	Flat capital femoral epiphysis (HP:0003370)	2.04767485
69	Limb dystonia (HP:0002451)	2.02321726
70	Respiratory distress (HP:0002098)	1.99946160
71	Congenital stationary night blindness (HP:0007642)	1.98820471
72	Patellar aplasia (HP:0006443)	1.96801541
73	Resting tremor (HP:0002322)	1.96366569
74	Impulsivity (HP:0100710)	1.94435351
75	Abnormal urine output (HP:0012590)	1.94432500
76	Congenital malformation of the right heart (HP:0011723)	1.92091783
77	Double outlet right ventricle (HP:0001719)	1.92091783
78	Pendular nystagmus (HP:0012043)	1.92071168
79	Abnormality of the pubic bones (HP:0003172)	1.91971155
80	Horizontal nystagmus (HP:0000666)	1.91947874
81	Cone-rod dystrophy (HP:0000548)	1.89485155
82	Abnormal spermatogenesis (HP:0008669)	1.87845087
83	Short palpebral fissure (HP:0012745)	1.86267238
84	Focal segmental glomerulosclerosis (HP:0000097)	1.84206498
85	Hyperkalemia (HP:0002153)	1.84094596
86	Rhinitis (HP:0012384)	1.83560649
87	Sclerocornea (HP:0000647)	1.81224864
88	Depressed nasal tip (HP:0000437)	1.80609234
89	Failure to thrive in infancy (HP:0001531)	1.79292075
90	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.78219149
91	Abnormality of the renal medulla (HP:0100957)	1.76668913
92	Progressive cerebellar ataxia (HP:0002073)	1.76249052
93	Atelectasis (HP:0100750)	1.74300566
94	Bradycardia (HP:0001662)	1.72133193
95	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71265732
96	Large eyes (HP:0001090)	1.71172949
97	Renovascular hypertension (HP:0100817)	1.70902290
98	Polyuria (HP:0000103)	1.70106266
99	Supernumerary spleens (HP:0009799)	1.69891310
100	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.67751351

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	7.60786924
2	PLK4	6.21737500
3	DDR2	4.16446224
4	TESK1	3.85427093
5	ZAK	3.63845043
6	VRK1	3.45120676
7	TLK1	2.73893896
8	MAPK15	2.72805791
9	INSRR	2.51471100
10	PLK2	2.26789832
11	PIM2	1.88162974
12	PNCK	1.74474281
13	DYRK3	1.73217046
14	RPS6KA5	1.57741992
15	AURKA	1.52671951
16	CCNB1	1.36003587
17	CDK12	1.34876312
18	UHMK1	1.33024313
19	PKN1	1.32815039
20	DAPK3	1.31730736
21	BCKDK	1.26365411
22	DYRK1B	1.19762032
23	BRD4	1.14480227
24	VRK2	1.11722937
25	PASK	1.10988759
26	TAF1	1.10915655
27	WNK1	1.03150962
28	CDK7	1.02821634
29	PIK3CG	1.01157258
30	MAP2K7	0.99018758
31	ADRBK2	0.89429213
32	CDK3	0.87392864
33	LATS2	0.85568758
34	NUAK1	0.78573267
35	BRAF	0.73949042
36	STK38	0.70915525
37	PTK2B	0.67372587
38	WEE1	0.59774942
39	RPS6KA2	0.58540557
40	CHEK2	0.54876500
41	MARK1	0.53628553
42	TESK2	0.53508584
43	AURKB	0.53410655
44	DYRK2	0.52619351
45	KIT	0.52433922
46	MAPKAPK5	0.52313156
47	CDC7	0.51558544
48	ARAF	0.51555912
49	RPS6KA4	0.50749441
50	TSSK6	0.50734917
51	PDPK1	0.50396966
52	RPS6KA6	0.50172814
53	PAK2	0.48718171
54	RPS6KA1	0.48590598
55	PDK1	0.47323952
56	PRKD3	0.44566236
57	SRPK1	0.43746672
58	BRSK2	0.42735809
59	BMPR1B	0.41480578
60	BCR	0.41358120
61	MAP3K4	0.41265305
62	MAP2K2	0.40635536
63	STK38L	0.36374105
64	ROCK1	0.35833302
65	PRKG1	0.35609441
66	CSNK1G2	0.34407556
67	MAPK13	0.34327242
68	CDK2	0.34062987
69	NME2	0.33880645
70	NEK2	0.32791293
71	RAF1	0.31848881
72	BRSK1	0.29884983
73	PLK3	0.28519008
74	GSK3B	0.28461568
75	CLK1	0.28425747
76	CDK9	0.28212606
77	RPS6KL1	0.27653438
78	RPS6KC1	0.27653438
79	MAPK1	0.26331716
80	CAMK1G	0.25840983
81	CDK1	0.25705831
82	DAPK2	0.25356249
83	CSNK1G3	0.24587102
84	CHEK1	0.24193950
85	BUB1	0.22891372
86	CSF1R	0.22489073
87	PRKAA1	0.21958172
88	MOS	0.21828103
89	ADRBK1	0.20582298
90	CDK4	0.20405011
91	CDK11A	0.20385520
92	AKT2	0.20262827
93	CSNK1A1	0.18799117
94	MAP3K5	0.18718202
95	CDK14	0.18298688
96	STK16	0.18101239
97	PBK	0.17468794
98	MTOR	0.17172977
99	AKT1	0.16695069
100	BTK	0.16504975

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.20266322
2	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.63087157
3	Alcoholism_Homo sapiens_hsa05034	4.52055700
4	Butanoate metabolism_Homo sapiens_hsa00650	2.92138674
5	Allograft rejection_Homo sapiens_hsa05330	2.72302569
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.64594095
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.46968166
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.34592411
9	Olfactory transduction_Homo sapiens_hsa04740	2.28748801
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.08219984
11	Viral myocarditis_Homo sapiens_hsa05416	2.03328801
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.02966134
13	Viral carcinogenesis_Homo sapiens_hsa05203	1.85772898
14	Phototransduction_Homo sapiens_hsa04744	1.85032440
15	Taste transduction_Homo sapiens_hsa04742	1.79480033
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.75932469
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.68849065
18	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.54945741
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.43684605
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.38845282
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.33443707
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25412434
23	Basal cell carcinoma_Homo sapiens_hsa05217	1.25306697
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18650044
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16457022
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.15231396
27	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.11411827
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09218144
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08183972
30	Huntingtons disease_Homo sapiens_hsa05016	1.03830964
31	GABAergic synapse_Homo sapiens_hsa04727	1.03811230
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.02191752
33	Spliceosome_Homo sapiens_hsa03040	1.00194894
34	Type II diabetes mellitus_Homo sapiens_hsa04930	0.95501909
35	Sulfur relay system_Homo sapiens_hsa04122	0.95461994
36	RNA transport_Homo sapiens_hsa03013	0.95421910
37	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.95055580
38	Nicotine addiction_Homo sapiens_hsa05033	0.94250734
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92123063
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.91306517
41	Morphine addiction_Homo sapiens_hsa05032	0.87825497
42	Parkinsons disease_Homo sapiens_hsa05012	0.85104050
43	Tyrosine metabolism_Homo sapiens_hsa00350	0.83184329
44	Oxidative phosphorylation_Homo sapiens_hsa00190	0.81566585
45	Circadian entrainment_Homo sapiens_hsa04713	0.81456838
46	Salivary secretion_Homo sapiens_hsa04970	0.79870586
47	Purine metabolism_Homo sapiens_hsa00230	0.79244757
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77292574
49	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.76617635
50	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.73856495
51	Asthma_Homo sapiens_hsa05310	0.70218876
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.67123382
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66766449
54	Basal transcription factors_Homo sapiens_hsa03022	0.65751694
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63669682
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.63264366
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54412928
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.52698658
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51487110
60	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51124972
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.51100452
62	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50325186
63	Serotonergic synapse_Homo sapiens_hsa04726	0.49953806
64	Endocytosis_Homo sapiens_hsa04144	0.48125515
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.45782425
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44975366
67	Propanoate metabolism_Homo sapiens_hsa00640	0.41643738
68	RNA polymerase_Homo sapiens_hsa03020	0.36802242
69	Lysine degradation_Homo sapiens_hsa00310	0.36277243
70	Fatty acid degradation_Homo sapiens_hsa00071	0.36104162
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35334585
72	Phagosome_Homo sapiens_hsa04145	0.34747422
73	Oocyte meiosis_Homo sapiens_hsa04114	0.34405262
74	Bladder cancer_Homo sapiens_hsa05219	0.34318738
75	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.33241365
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.32761632
77	Notch signaling pathway_Homo sapiens_hsa04330	0.32422389
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32389461
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.32149181
80	Base excision repair_Homo sapiens_hsa03410	0.31489743
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.31284680
82	Alzheimers disease_Homo sapiens_hsa05010	0.29781335
83	Influenza A_Homo sapiens_hsa05164	0.29478842
84	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.29088683
85	Herpes simplex infection_Homo sapiens_hsa05168	0.28794443
86	Cell cycle_Homo sapiens_hsa04110	0.27385445
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.26905563
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25861307
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.25789356
90	Cocaine addiction_Homo sapiens_hsa05030	0.25774645
91	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22274144
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.21802381
93	Melanogenesis_Homo sapiens_hsa04916	0.21519017
94	Axon guidance_Homo sapiens_hsa04360	0.20213809
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.20201823
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.19390557
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.19336406
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.18075695
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.17941170
100	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.17881806

FSCN1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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