FSCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)9.72183357
2phototransduction (GO:0007602)9.56086030
3phototransduction, visible light (GO:0007603)9.53458218
4detection of light stimulus involved in sensory perception (GO:0050962)9.50001294
5detection of light stimulus involved in visual perception (GO:0050908)9.50001294
6detection of light stimulus (GO:0009583)9.11742727
7detection of visible light (GO:0009584)9.09690732
8retinal rod cell development (GO:0046548)8.21544308
9GDP-mannose metabolic process (GO:0019673)7.81657980
10cellular response to light stimulus (GO:0071482)7.76965185
11* visual perception (GO:0007601)7.69808750
12* sensory perception of light stimulus (GO:0050953)7.61006550
13photoreceptor cell differentiation (GO:0046530)7.45266175
14eye photoreceptor cell differentiation (GO:0001754)7.45266175
15cellular response to ATP (GO:0071318)7.37544227
16regulation of cGMP metabolic process (GO:0030823)7.15238349
17DNA strand renaturation (GO:0000733)6.82185838
18negative regulation of cell aging (GO:0090344)6.78945413
19retina development in camera-type eye (GO:0060041)6.64838580
20positive regulation of cGMP biosynthetic process (GO:0030828)6.59575828
21adenosine receptor signaling pathway (GO:0001973)6.54888962
22receptor guanylyl cyclase signaling pathway (GO:0007168)6.42923461
23detection of external stimulus (GO:0009581)6.31298056
24detection of abiotic stimulus (GO:0009582)6.19794930
25regulation of cGMP biosynthetic process (GO:0030826)6.19082099
26positive regulation of protein kinase C signaling (GO:0090037)6.02027770
27regulation of skeletal muscle contraction (GO:0014819)5.92821908
28adenine nucleotide transport (GO:0051503)5.88034957
29positive regulation of cGMP metabolic process (GO:0030825)5.81721730
30protein-chromophore linkage (GO:0018298)5.69535990
31G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.64709096
32meiotic chromosome segregation (GO:0045132)5.49560968
33purine ribonucleotide transport (GO:0015868)5.42274231
34nonmotile primary cilium assembly (GO:0035058)5.39942576
35cellular response to radiation (GO:0071478)5.03765879
36cell morphogenesis involved in neuron differentiation (GO:0048667)5.00551399
37protein carboxylation (GO:0018214)4.95152341
38peptidyl-glutamic acid carboxylation (GO:0017187)4.95152341
39semaphorin-plexin signaling pathway (GO:0071526)4.93214762
40purinergic nucleotide receptor signaling pathway (GO:0035590)4.89790995
41lens fiber cell differentiation (GO:0070306)4.81472151
42purine nucleotide transport (GO:0015865)4.79920929
43negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.75575258
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.73658493
45rRNA methylation (GO:0031167)4.70884890
46UV protection (GO:0009650)4.64233109
47mannose metabolic process (GO:0006013)4.52373841
48sensory perception of taste (GO:0050909)4.47979504
49adaptation of signaling pathway (GO:0023058)4.35308048
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.25696655
51regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.22750659
52protein prenylation (GO:0018342)4.19267285
53prenylation (GO:0097354)4.19267285
54regulation of synapse structural plasticity (GO:0051823)4.18373259
55nucleotide-sugar biosynthetic process (GO:0009226)4.15400370
56urinary tract smooth muscle contraction (GO:0014848)4.10270687
57mitotic cell cycle arrest (GO:0071850)4.09831206
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.08907891
59retina layer formation (GO:0010842)4.05529693
60regulation of voltage-gated calcium channel activity (GO:1901385)4.04602946
61nucleoside transmembrane transport (GO:1901642)3.95865569
62rRNA modification (GO:0000154)3.93051495
63planar cell polarity pathway involved in neural tube closure (GO:0090179)3.90980624
64short-term memory (GO:0007614)3.87426300
65response to ATP (GO:0033198)3.86884198
66purinergic receptor signaling pathway (GO:0035587)3.80557971
67histone phosphorylation (GO:0016572)3.80514065
68atrioventricular valve morphogenesis (GO:0003181)3.80441337
69endocytic recycling (GO:0032456)3.75248153
70folic acid metabolic process (GO:0046655)3.74610714
71protein localization to synapse (GO:0035418)3.73610335
72G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.72765273
73regulation of cytokine production involved in inflammatory response (GO:1900015)3.71298162
74negative regulation of receptor-mediated endocytosis (GO:0048261)3.66892093
75protein retention in ER lumen (GO:0006621)3.65386684
76ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.60257401
77nucleoside bisphosphate biosynthetic process (GO:0033866)3.60257401
78purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.60257401
79regulation of cell aging (GO:0090342)3.54639602
80retina homeostasis (GO:0001895)3.52811735
81response to light stimulus (GO:0009416)3.51752940
82* sensory perception (GO:0007600)3.51519290
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48932978
84nucleotide transmembrane transport (GO:1901679)3.46832429
85positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.42540927
86sphingomyelin metabolic process (GO:0006684)3.41199496
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39751367
88mitochondrion transport along microtubule (GO:0047497)3.39726626
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.39726626
90oxidative demethylation (GO:0070989)3.39085114
91cell-substrate adherens junction assembly (GO:0007045)3.38008083
92focal adhesion assembly (GO:0048041)3.38008083
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.34326049
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.34326049
95behavioral response to ethanol (GO:0048149)3.33920175
96sex determination (GO:0007530)3.31738329
97detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.26944103
98transcription from mitochondrial promoter (GO:0006390)3.21813798
99cellular response to virus (GO:0098586)3.21758313
100regulation of phospholipid biosynthetic process (GO:0071071)3.19275453
101regulation of penile erection (GO:0060405)3.19102483
102type B pancreatic cell proliferation (GO:0044342)3.17353790
103desmosome organization (GO:0002934)3.14032743
104urogenital system development (GO:0001655)3.11891316
105regulation of clathrin-mediated endocytosis (GO:2000369)3.10087490
106chemosensory behavior (GO:0007635)3.09007414
107* neuron development (GO:0048666)3.07443195
108granulocyte differentiation (GO:0030851)3.04504072
109adherens junction assembly (GO:0034333)3.04031695
110nucleoside transport (GO:0015858)3.01569981
111regulation of protein kinase A signaling (GO:0010738)3.01545364
112sphingosine metabolic process (GO:0006670)3.00935230
113axoneme assembly (GO:0035082)3.00785317
114mitochondrion distribution (GO:0048311)3.00417515
115proline biosynthetic process (GO:0006561)2.97021897
116melanin biosynthetic process (GO:0042438)2.94459070
117epithelial cell-cell adhesion (GO:0090136)2.94363165
118response to histamine (GO:0034776)2.93433523
119positive regulation of sodium ion transmembrane transport (GO:1902307)2.93008935
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92393659
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.91735328
122establishment of mitochondrion localization (GO:0051654)2.91025923
123phosphate ion homeostasis (GO:0055062)2.89154748
124trivalent inorganic anion homeostasis (GO:0072506)2.89154748
125diol metabolic process (GO:0034311)2.87850830
126phosphate ion transmembrane transport (GO:0035435)2.87706094
127melanin metabolic process (GO:0006582)2.87585492
128basement membrane organization (GO:0071711)2.86896885
129activation of Rac GTPase activity (GO:0032863)2.86603101
130mRNA cleavage (GO:0006379)2.86434437
131negative regulation of cell size (GO:0045792)2.84564568
132endothelial cell chemotaxis (GO:0035767)2.84308234
133behavioral response to cocaine (GO:0048148)2.81251413
134peristalsis (GO:0030432)2.80359994
135grooming behavior (GO:0007625)2.79600682
136protein insertion into membrane (GO:0051205)2.78283117
137negative regulation of JAK-STAT cascade (GO:0046426)2.78256184
138cell migration in hindbrain (GO:0021535)2.76472722
139regulation of fatty acid beta-oxidation (GO:0031998)2.76033707
140modulation by virus of host process (GO:0019054)2.75378683
141phosphatidylglycerol biosynthetic process (GO:0006655)2.74946318
142arachidonic acid secretion (GO:0050482)2.74181823
143icosanoid secretion (GO:0032309)2.74181823
144dopamine receptor signaling pathway (GO:0007212)2.72435146
145regulation of translational fidelity (GO:0006450)2.72336488
146regulation of chromatin binding (GO:0035561)2.71971444
147negative regulation of interleukin-8 production (GO:0032717)2.71643034
148positive regulation of heat generation (GO:0031652)2.71516923
149cell-cell junction maintenance (GO:0045217)2.71389616
150viral mRNA export from host cell nucleus (GO:0046784)2.70412014
151modulation by symbiont of host cellular process (GO:0044068)2.68439433
152DNA duplex unwinding (GO:0032508)2.67532448
153CDP-diacylglycerol biosynthetic process (GO:0016024)2.67194970
154establishment of apical/basal cell polarity (GO:0035089)2.66377458
155proline metabolic process (GO:0006560)2.65557900
156cellular anion homeostasis (GO:0030002)2.62969803
157snRNA metabolic process (GO:0016073)2.61207835
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.60941656
159regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60364779
160respiratory tube development (GO:0030323)2.59772001
161negative regulation of mast cell activation (GO:0033004)2.59553407
162cell-substrate junction assembly (GO:0007044)2.57209902
163transepithelial transport (GO:0070633)2.56087751
164negative regulation of cation channel activity (GO:2001258)2.55865988
165apoptotic process involved in morphogenesis (GO:0060561)2.54662806
166negative regulation of calcium ion transmembrane transport (GO:1903170)2.53574887
167negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.53574887
168negative regulation of fatty acid transport (GO:2000192)2.53191810
169positive regulation of keratinocyte differentiation (GO:0045618)2.53132845
170regulation of protein kinase C signaling (GO:0090036)2.51246542
171negative regulation of appetite (GO:0032099)2.50880768
172negative regulation of response to food (GO:0032096)2.50880768
173synaptic transmission, dopaminergic (GO:0001963)2.50410046
174cellular response to abiotic stimulus (GO:0071214)2.45712069
175CDP-diacylglycerol metabolic process (GO:0046341)2.45670033
176regulation of cilium movement (GO:0003352)2.44871270
177positive regulation of cyclase activity (GO:0031281)2.42898385
178response to radiation (GO:0009314)2.42468908
179positive regulation of neurotransmitter transport (GO:0051590)2.37491904
180post-embryonic morphogenesis (GO:0009886)2.35497634
181membrane hyperpolarization (GO:0060081)2.28614752
182regulation of RNA export from nucleus (GO:0046831)2.24951983
183regulation of transcription regulatory region DNA binding (GO:2000677)2.22779502
184retinol metabolic process (GO:0042572)2.21345038
185positive regulation of lyase activity (GO:0051349)2.19745906
186embryonic placenta development (GO:0001892)2.19208301
187regulation of neurotransmitter uptake (GO:0051580)2.18289778
188melanosome transport (GO:0032402)2.16853166
189mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.13687254
190positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.13687254
191synaptic vesicle endocytosis (GO:0048488)2.13560040
192regulation of rhodopsin mediated signaling pathway (GO:0022400)18.7650217
193rhodopsin mediated signaling pathway (GO:0016056)18.1257776
194retinal cone cell development (GO:0046549)12.8790952
195GMP metabolic process (GO:0046037)11.7974251
196photoreceptor cell maintenance (GO:0045494)11.4021755
197positive regulation of guanylate cyclase activity (GO:0031284)10.7633282
198* photoreceptor cell development (GO:0042461)10.6928394
199* eye photoreceptor cell development (GO:0042462)10.1604691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.57035068
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.35846767
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.45858032
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.40516580
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.13351222
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.01988355
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.85926554
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81280092
9RACK7_27058665_Chip-Seq_MCF-7_Human2.64541118
10VDR_22108803_ChIP-Seq_LS180_Human2.47962655
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.38455037
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33703329
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30926749
14LXR_22292898_ChIP-Seq_THP-1_Human2.26355784
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.22785502
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22401766
17KDM2B_26808549_Chip-Seq_K562_Human2.15316983
18MAF_26560356_Chip-Seq_TH2_Human2.10892250
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.02616600
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.00718919
21XRN2_22483619_ChIP-Seq_HELA_Human1.99282137
22VDR_24763502_ChIP-Seq_THP-1_Human1.95876183
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.95043736
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.93406302
25CTCF_27219007_Chip-Seq_ERYTHROID_Human1.91959332
26TCF7_22412390_ChIP-Seq_EML_Mouse1.91217155
27RING1B_27294783_Chip-Seq_NPCs_Mouse1.86844485
28* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.86149363
29BCOR_27268052_Chip-Seq_Bcells_Human1.85452241
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85280859
31MAF_26560356_Chip-Seq_TH1_Human1.82563978
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81663049
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79485241
34SMC4_20622854_ChIP-Seq_HELA_Human1.74396547
35VDR_21846776_ChIP-Seq_THP-1_Human1.69328286
36TP53_22127205_ChIP-Seq_IMR90_Human1.68200916
37RARB_24833708_ChIP-Seq_LIVER_Mouse1.66831000
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62930467
39* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.62376553
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62102102
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.61045252
42P68_20966046_ChIP-Seq_HELA_Human1.56755758
43CTCF_27219007_Chip-Seq_Bcells_Human1.56689042
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55258653
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.55139562
46CREB1_26743006_Chip-Seq_LNCaP_Human1.53658199
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.53274695
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52597215
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50507627
50* RARA_24833708_ChIP-Seq_LIVER_Mouse1.50028712
51KDM2B_26808549_Chip-Seq_DND41_Human1.49017372
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48878563
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48371157
54CTCF_21964334_Chip-Seq_Bcells_Human1.48030068
55ATF3_27146783_Chip-Seq_COLON_Human1.47101401
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46250734
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.46021327
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43444923
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.43246171
60UTX_26944678_Chip-Seq_JUKART_Human1.42919208
61* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42426113
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.42420921
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.42116096
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41186689
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41093713
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39927234
67* FOXP1_21924763_ChIP-Seq_HESCs_Human1.38974537
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.37041239
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.36599972
70E2F1_20622854_ChIP-Seq_HELA_Human1.36161401
71DROSHA_22980978_ChIP-Seq_HELA_Human1.35695057
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35158307
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34936334
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31571822
75* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30380578
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29786979
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27869726
78OCT4_19829295_ChIP-Seq_ESCs_Human1.27178178
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25411832
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25275142
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24915830
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24682815
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24095711
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23942749
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.23122171
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22495544
87NCOR1_26117541_ChIP-Seq_K562_Human1.21336724
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20156430
89* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19984805
90ZNF263_19887448_ChIP-Seq_K562_Human1.19917332
91* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18957328
92CTCF_20526341_ChIP-Seq_ESCs_Human1.18432682
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18294806
94* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18282347
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18215229
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17750625
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17029193
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.15126716
99SA1_27219007_Chip-Seq_Bcells_Human1.15019058
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14782051
101SMAD4_21741376_ChIP-Seq_ESCs_Human1.13547445
102* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13120986
103* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12491192
104TP63_22573176_ChIP-Seq_HFKS_Human1.12309541
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11328144
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10941865
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.10812399
108* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10305831
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10278820
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09749651
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08586958
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08244357
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07820393
114REST_21632747_ChIP-Seq_MESCs_Mouse1.07818746
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07537875
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06468064
117* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05996193
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.05963219
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05754586
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04918565
121* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04913703
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04651200
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04403280
124AR_19668381_ChIP-Seq_PC3_Human1.04224188
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04021793
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03897023
127PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03297264
128ETS1_21867929_ChIP-Seq_TH2_Mouse1.02352189
129AR_21572438_ChIP-Seq_LNCaP_Human1.02171680
130P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01875165
131DCP1A_22483619_ChIP-Seq_HELA_Human1.01862001
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01097000
133PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00159133
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99571099
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99239723
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98716469
137BCL6_27268052_Chip-Seq_Bcells_Human0.98231528
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98119857
139* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97789902
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96827367
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.96747028
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96659181
143* SPI1_26923725_Chip-Seq_HPCs_Mouse0.96170699
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95839680
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94090158
146PHF8_20622854_ChIP-Seq_HELA_Human0.92181817
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91977960
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91823859
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.90698181
150* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90179548
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89931019
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88996609
153MYC_22102868_ChIP-Seq_BL_Human0.88867695
154TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88477334
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87707329
156TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86814433
157P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86745196
158TBL1_22424771_ChIP-Seq_293T_Human0.86730344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.52671571
2MP0003011_delayed_dark_adaptation9.02775964
3MP0006072_abnormal_retinal_apoptosis6.96299329
4MP0005253_abnormal_eye_physiology6.94409879
5MP0003950_abnormal_plasma_membrane5.48925546
6MP0005174_abnormal_tail_pigmentation4.56102583
7MP0003136_yellow_coat_color4.02450201
8MP0003705_abnormal_hypodermis_morpholog3.96835417
9MP0005409_darkened_coat_color3.88607654
10* MP0005195_abnormal_posterior_eye3.87254205
11MP0002638_abnormal_pupillary_reflex3.81841164
12MP0001324_abnormal_eye_pigmentation3.69753620
13MP0005391_vision/eye_phenotype3.43774817
14MP0001764_abnormal_homeostasis2.72190618
15MP0005083_abnormal_biliary_tract2.51707755
16MP0001188_hyperpigmentation2.43913697
17MP0002229_neurodegeneration2.27702470
18MP0003453_abnormal_keratinocyte_physiol2.18879938
19MP0005423_abnormal_somatic_nervous2.16543814
20MP0002090_abnormal_vision2.08811085
21MP0004233_abnormal_muscle_weight2.07328194
22MP0000750_abnormal_muscle_regeneration2.06566026
23MP0004381_abnormal_hair_follicle1.97660056
24MP0000538_abnormal_urinary_bladder1.97025056
25MP0001348_abnormal_lacrimal_gland1.94881214
26* MP0002752_abnormal_somatic_nervous1.86260500
27MP0001958_emphysema1.81971182
28MP0001756_abnormal_urination1.79178557
29MP0005257_abnormal_intraocular_pressure1.77055438
30MP0003091_abnormal_cell_migration1.74975745
31MP0001986_abnormal_taste_sensitivity1.71130698
32MP0001661_extended_life_span1.71047898
33MP0005501_abnormal_skin_physiology1.70578056
34MP0000015_abnormal_ear_pigmentation1.60479283
35MP0000003_abnormal_adipose_tissue1.60073294
36MP0003111_abnormal_nucleus_morphology1.59314588
37MP0005058_abnormal_lysosome_morphology1.58270803
38MP0002653_abnormal_ependyma_morphology1.55849817
39MP0010234_abnormal_vibrissa_follicle1.53720820
40MP0000747_muscle_weakness1.48054720
41MP0004858_abnormal_nervous_system1.44684256
42MP0001968_abnormal_touch/_nociception1.43741480
43MP0000013_abnormal_adipose_tissue1.40735748
44MP0004185_abnormal_adipocyte_glucose1.40632487
45MP0009384_cardiac_valve_regurgitation1.39186459
46MP0005451_abnormal_body_composition1.37987550
47* MP0002882_abnormal_neuron_morphology1.35672985
48MP0001873_stomach_inflammation1.26187310
49MP0003279_aneurysm1.24599842
50MP0008057_abnormal_DNA_replication1.17709831
51MP0003566_abnormal_cell_adhesion1.17121739
52MP0005187_abnormal_penis_morphology1.12677677
53MP0004130_abnormal_muscle_cell1.12173205
54MP0002254_reproductive_system_inflammat1.11985906
55MP0002796_impaired_skin_barrier1.10873310
56MP0008875_abnormal_xenobiotic_pharmacok1.10639192
57MP0000537_abnormal_urethra_morphology1.07595100
58MP0004087_abnormal_muscle_fiber1.06018576
59MP0004264_abnormal_extraembryonic_tissu1.03190610
60MP0001765_abnormal_ion_homeostasis1.01098394
61MP0003890_abnormal_embryonic-extraembry0.99155633
62MP0001502_abnormal_circadian_rhythm0.98636306
63MP0010030_abnormal_orbit_morphology0.98413892
64MP0005076_abnormal_cell_differentiation0.98235910
65MP0005377_hearing/vestibular/ear_phenot0.97951255
66MP0003878_abnormal_ear_physiology0.97951255
67MP0009931_abnormal_skin_appearance0.97581689
68MP0003634_abnormal_glial_cell0.97325463
69MP0005197_abnormal_uvea_morphology0.97304870
70MP0000767_abnormal_smooth_muscle0.96821453
71MP0005623_abnormal_meninges_morphology0.95884982
72MP0002735_abnormal_chemical_nociception0.94717411
73MP0004019_abnormal_vitamin_homeostasis0.93092041
74MP0002127_abnormal_cardiovascular_syste0.91848477
75MP0005375_adipose_tissue_phenotype0.91726200
76MP0001984_abnormal_olfaction0.91216350
77MP0003880_abnormal_central_pattern0.90097964
78MP0002332_abnormal_exercise_endurance0.89522842
79MP0004885_abnormal_endolymph0.89379676
80MP0008438_abnormal_cutaneous_collagen0.89306623
81MP0010771_integument_phenotype0.85578500
82MP0002249_abnormal_larynx_morphology0.84834875
83MP0003077_abnormal_cell_cycle0.84802545
84MP0001664_abnormal_digestion0.84349467
85MP0000733_abnormal_muscle_development0.82305337
86MP0003693_abnormal_embryo_hatching0.81023277
87MP0010630_abnormal_cardiac_muscle0.79637713
88MP0000367_abnormal_coat/_hair0.78887387
89MP0009278_abnormal_bone_marrow0.78527999
90MP0008789_abnormal_olfactory_epithelium0.78487852
91MP0000470_abnormal_stomach_morphology0.78214402
92MP0002060_abnormal_skin_morphology0.78046492
93MP0005499_abnormal_olfactory_system0.77779912
94MP0005394_taste/olfaction_phenotype0.77779912
95MP0005666_abnormal_adipose_tissue0.77390875
96MP0002160_abnormal_reproductive_system0.77266419
97MP0002736_abnormal_nociception_after0.76508783
98MP0004957_abnormal_blastocyst_morpholog0.75903328
99MP0003448_altered_tumor_morphology0.75633339
100MP0005584_abnormal_enzyme/coenzyme_acti0.75540541
101MP0002086_abnormal_extraembryonic_tissu0.74326812
102MP0001216_abnormal_epidermal_layer0.73669969
103MP0004145_abnormal_muscle_electrophysio0.71019251
104MP0000377_abnormal_hair_follicle0.70945742
105MP0003045_fibrosis0.68621729
106MP0005376_homeostasis/metabolism_phenot0.68488214
107MP0000358_abnormal_cell_content/0.66873960
108MP0003984_embryonic_growth_retardation0.64351290
109MP0005621_abnormal_cell_physiology0.63696441
110MP0010094_abnormal_chromosome_stability0.63364058
111MP0002019_abnormal_tumor_incidence0.62709215
112MP0001286_abnormal_eye_development0.62497046
113MP0001849_ear_inflammation0.62035223
114MP0000534_abnormal_ureter_morphology0.61254352
115MP0008995_early_reproductive_senescence0.60670072
116MP0008058_abnormal_DNA_repair0.60408261
117MP0009840_abnormal_foam_cell0.60403395
118MP0002080_prenatal_lethality0.60225159
119MP0002075_abnormal_coat/hair_pigmentati0.59900339
120MP0009643_abnormal_urine_homeostasis0.59743666
121MP0002136_abnormal_kidney_physiology0.59560992
122MP0000751_myopathy0.59488023
123MP0002088_abnormal_embryonic_growth/wei0.59252062
124MP0002909_abnormal_adrenal_gland0.59210620
125MP0005332_abnormal_amino_acid0.57404051
126MP0003942_abnormal_urinary_system0.57400575
127MP0000678_abnormal_parathyroid_gland0.55502936
128MP0005023_abnormal_wound_healing0.55385495
129MP0002098_abnormal_vibrissa_morphology0.55336229
130MP0002272_abnormal_nervous_system0.47781564
131MP0004133_heterotaxia0.46553304
132MP0005171_absent_coat_pigmentation0.45233879
133MP0002009_preneoplasia0.44804169
134MP0004142_abnormal_muscle_tone0.42093122
135MP0002269_muscular_atrophy0.39656409
136MP0000462_abnormal_digestive_system0.38552991
137MP0006292_abnormal_olfactory_placode0.37957240
138MP0009046_muscle_twitch0.37582944
139MP0003137_abnormal_impulse_conducting0.37568891
140MP0001486_abnormal_startle_reflex0.37393146
141MP0002572_abnormal_emotion/affect_behav0.37151200
142MP0002063_abnormal_learning/memory/cond0.35833704
143MP0003119_abnormal_digestive_system0.34941733
144MP0003283_abnormal_digestive_organ0.34747698
145MP0005330_cardiomyopathy0.33617483
146MP0004270_analgesia0.32284423
147MP0002697_abnormal_eye_size0.32279335
148MP0002067_abnormal_sensory_capabilities0.30444528
149MP0002064_seizures0.29426727
150MP0000631_abnormal_neuroendocrine_gland0.29268409
151MP0002108_abnormal_muscle_morphology0.28369582
152MP0005266_abnormal_metabolism0.27618942
153MP0002928_abnormal_bile_duct0.26798067
154MP0002152_abnormal_brain_morphology0.26087818
155MP0004811_abnormal_neuron_physiology0.26037788
156* MP0001963_abnormal_hearing_physiology0.25690879
157MP0002734_abnormal_mechanical_nocicepti0.25459950
158MP0003861_abnormal_nervous_system0.24559494
159MP0002971_abnormal_brown_adipose0.24270196
160MP0002282_abnormal_trachea_morphology0.24141033
161MP0002066_abnormal_motor_capabilities/c0.23851013
162MP0002184_abnormal_innervation0.23462738
163MP0000778_abnormal_nervous_system0.23246495
164MP0000749_muscle_degeneration0.23114643
165* MP0000026_abnormal_inner_ear0.22503273
166MP0002085_abnormal_embryonic_tissue0.21167693
167MP0005620_abnormal_muscle_contractility0.20944540
168MP0002084_abnormal_developmental_patter0.20888877
169MP0004085_abnormal_heartbeat0.20861192
170MP0005193_abnormal_anterior_eye0.20306772
171MP0005220_abnormal_exocrine_pancreas0.20140048
172MP0003638_abnormal_response/metabolism_0.20014870
173MP0001293_anophthalmia0.19909076
174MP0004197_abnormal_fetal_growth/weight/0.19355526
175MP0002168_other_aberrant_phenotype0.18721658
176MP0005386_behavior/neurological_phenoty0.18673346
177MP0004924_abnormal_behavior0.18673346
178MP0000759_abnormal_skeletal_muscle0.18654677
179MP0009115_abnormal_fat_cell0.18464391
180MP0004215_abnormal_myocardial_fiber0.18170497
181MP0010768_mortality/aging0.18129445
182MP0010770_preweaning_lethality0.17851770
183MP0002082_postnatal_lethality0.17851770
184MP0004782_abnormal_surfactant_physiolog0.17337818
185MP0010769_abnormal_survival0.17227991
186MP0001697_abnormal_embryo_size0.17071286

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.68939503
2* Chorioretinal atrophy (HP:0000533)8.46886533
3Pendular nystagmus (HP:0012043)8.18640818
4Central scotoma (HP:0000603)7.16585235
5Testicular atrophy (HP:0000029)6.78825176
6Scotoma (HP:0000575)6.72031604
7* Attenuation of retinal blood vessels (HP:0007843)6.59131368
8Abnormality of macular pigmentation (HP:0008002)6.20979153
9Thin bony cortex (HP:0002753)6.09344198
10Abolished electroretinogram (ERG) (HP:0000550)6.01356573
11* Type II diabetes mellitus (HP:0005978)5.79381719
12Ulnar bowing (HP:0003031)5.64569342
13Decreased central vision (HP:0007663)5.53720331
14Keratoconus (HP:0000563)5.49136686
15Increased corneal curvature (HP:0100692)5.49136686
16* Photophobia (HP:0000613)5.46807554
17Dyschromatopsia (HP:0007641)5.46588629
18Rib fusion (HP:0000902)5.36488032
19Vitreoretinal degeneration (HP:0000655)5.19766412
20* Retinitis pigmentosa (HP:0000510)4.77773767
21Choroideremia (HP:0001139)4.72041134
22Cone-rod dystrophy (HP:0000548)4.71708485
23Turricephaly (HP:0000262)4.60010600
24Rectovaginal fistula (HP:0000143)4.42586022
25Rectal fistula (HP:0100590)4.42586022
26Macular degeneration (HP:0000608)4.33379233
27Vaginal fistula (HP:0004320)4.30846455
28Aplasia of the musculature (HP:0100854)4.13706917
29Severe visual impairment (HP:0001141)3.89681420
30Constricted visual fields (HP:0001133)3.87903890
31Delayed epiphyseal ossification (HP:0002663)3.83276899
32Popliteal pterygium (HP:0009756)3.82356310
33Coronal craniosynostosis (HP:0004440)3.75831987
34Abnormality of the intrinsic pathway (HP:0010989)3.71639510
35Hemorrhage of the eye (HP:0011885)3.69006309
36Squamous cell carcinoma (HP:0002860)3.54085936
37Akinesia (HP:0002304)3.47376569
38Gait imbalance (HP:0002141)3.47186163
39Anteriorly placed anus (HP:0001545)3.46856555
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.43842941
41Congenital primary aphakia (HP:0007707)3.41232643
42Posterior subcapsular cataract (HP:0007787)3.21838813
43Short chin (HP:0000331)3.18862154
44Decreased electroretinogram (ERG) amplitude (HP:0000654)3.18106333
45Facial diplegia (HP:0001349)3.12675632
46Bowing of the arm (HP:0006488)3.07877426
47Bowed forearm bones (HP:0003956)3.07877426
48Nephrogenic diabetes insipidus (HP:0009806)3.05824551
49Mesangial abnormality (HP:0001966)2.98724368
50Fetal akinesia sequence (HP:0001989)2.91884401
51Joint stiffness (HP:0001387)2.89802278
52Medial flaring of the eyebrow (HP:0010747)2.87627901
53Enlarged epiphyses (HP:0010580)2.85154400
54Choanal stenosis (HP:0000452)2.76600170
55Optic disc pallor (HP:0000543)2.76001710
56Patellar aplasia (HP:0006443)2.72715079
57Retinal atrophy (HP:0001105)2.72250032
58Progressive visual loss (HP:0000529)2.66601485
59Abnormality of the costochondral junction (HP:0000919)2.65824358
60Atrioventricular block (HP:0001678)2.64790725
61* Wide nasal bridge (HP:0000431)2.64102718
62Poor coordination (HP:0002370)2.63499401
63Capillary hemangiomas (HP:0005306)2.62315275
64Hypophosphatemic rickets (HP:0004912)2.52368155
65Aplasia/Hypoplasia of the patella (HP:0006498)2.52131105
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51295204
67Cervical subluxation (HP:0003308)2.48850463
68Thin ribs (HP:0000883)2.48572271
69Amniotic constriction ring (HP:0009775)2.48046932
70Abnormality of placental membranes (HP:0011409)2.48046932
71Joint hemorrhage (HP:0005261)2.48017498
72Prolonged partial thromboplastin time (HP:0003645)2.47198993
73Widely patent fontanelles and sutures (HP:0004492)2.46253584
74Hypoalbuminemia (HP:0003073)2.40354470
75Abnormal albumin level (HP:0012116)2.40354470
76Flat occiput (HP:0005469)2.38788327
77Short humerus (HP:0005792)2.38243851
78Vaginal atresia (HP:0000148)2.36107489
79Male infertility (HP:0003251)2.33884105
80Broad face (HP:0000283)2.25467065
81Genital tract atresia (HP:0001827)2.24930099
82Pterygium (HP:0001059)2.24552198
83Narrow nasal bridge (HP:0000446)2.23299874
84Hyperacusis (HP:0010780)2.19021309
85Myotonia (HP:0002486)2.17624797
86Zonular cataract (HP:0010920)2.16058119
87Myopathic facies (HP:0002058)2.15888587
88Basal cell carcinoma (HP:0002671)2.10688225
89Increased number of teeth (HP:0011069)2.07756313
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07610252
91Tibial bowing (HP:0002982)2.06635459
92Neonatal onset (HP:0003623)2.04613699
93Aplasia/hypoplasia of the humerus (HP:0006507)2.04284909
94Congenital stationary night blindness (HP:0007642)16.3186806
95* Bony spicule pigmentary retinopathy (HP:0007737)11.1383070
96Abnormal rod and cone electroretinograms (HP:0008323)10.9723407
97Pigmentary retinal degeneration (HP:0001146)10.1238510
98Abnormal atrioventricular conduction (HP:0005150)1.98258789
99Abnormality of the fingertips (HP:0001211)1.96818997
100Congenital hip dislocation (HP:0001374)1.94759286
101Absent thumb (HP:0009777)1.92423792
102Spina bifida occulta (HP:0003298)1.91726808
103Progressive muscle weakness (HP:0003323)1.90950981
104Easy fatigability (HP:0003388)1.90721242
105Neonatal respiratory distress (HP:0002643)1.90501398
106Abnormal epiphyseal ossification (HP:0010656)1.86548321
107Aplasia/Hypoplasia of the lens (HP:0008063)1.84392701
108Wide cranial sutures (HP:0010537)1.84061341
109Heart block (HP:0012722)1.83394950
110Abnormal trabecular bone morphology (HP:0100671)1.83385313
111Asymmetric septal hypertrophy (HP:0001670)1.82105851
112Urinary glycosaminoglycan excretion (HP:0003541)1.81186039
113Mucopolysacchariduria (HP:0008155)1.81186039
114Premature graying of hair (HP:0002216)1.78824054
115Cheilitis (HP:0100825)1.78665105
116Breast hypoplasia (HP:0003187)1.76717351
117Slender long bone (HP:0003100)1.75573422
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74747629
119Abnormality of polysaccharide metabolism (HP:0011012)1.74747629
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74747629
121Malignant hyperthermia (HP:0002047)1.74720681
122Upper limb amyotrophy (HP:0009129)1.74636818
123Distal upper limb amyotrophy (HP:0007149)1.74636818
124Mask-like facies (HP:0000298)1.74488919
125Genu recurvatum (HP:0002816)1.73979193
126Subcapsular cataract (HP:0000523)1.73974258
127* Optic atrophy (HP:0000648)1.72450199
128Protrusio acetabuli (HP:0003179)1.72157301
129Congenital sensorineural hearing impairment (HP:0008527)1.68640961
130Progressive external ophthalmoplegia (HP:0000590)1.68347619
131Absent radius (HP:0003974)1.66530956
132Sparse lateral eyebrow (HP:0005338)1.64895600
133Dysdiadochokinesis (HP:0002075)1.62854852
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.62510011
135Emphysema (HP:0002097)1.62062052
136Partial agenesis of the corpus callosum (HP:0001338)1.61235680
137Specific learning disability (HP:0001328)1.56816202
138Cerebellar dysplasia (HP:0007033)1.55427015
139Decreased testicular size (HP:0008734)1.52752599
140Broad foot (HP:0001769)1.48624807
141Astigmatism (HP:0000483)1.47938288
142Left ventricular hypertrophy (HP:0001712)1.41548711
143Horizontal nystagmus (HP:0000666)1.38917906
144True hermaphroditism (HP:0010459)1.35096168
145Interstitial pulmonary disease (HP:0006530)1.28421938
146Increased IgM level (HP:0003496)1.28308199
147Heterotopia (HP:0002282)1.20761003
148Asthma (HP:0002099)1.20231746
149Severe Myopia (HP:0011003)1.14947823
150Exercise-induced myalgia (HP:0003738)1.13114135
151Short foot (HP:0001773)1.11578364
152Pancreatic fibrosis (HP:0100732)1.07789364
153Albinism (HP:0001022)1.06099210
154Dental crowding (HP:0000678)1.04215327
155Retinal detachment (HP:0000541)1.03820727
156Abnormality of the fovea (HP:0000493)1.02439856
157Epileptic encephalopathy (HP:0200134)1.01686466
158Cystic liver disease (HP:0006706)1.00635763
159Aplasia/Hypoplasia of the fovea (HP:0008060)0.97022361
160Hypoplasia of the fovea (HP:0007750)0.97022361
161Hypodontia (HP:0000668)0.96276938
162Intestinal fistula (HP:0100819)0.94126133
163Postaxial hand polydactyly (HP:0001162)0.90306719
164Annular pancreas (HP:0001734)0.89859507
165Poikiloderma (HP:0001029)0.89116084
166Truncal ataxia (HP:0002078)0.88931112
167Febrile seizures (HP:0002373)0.87972470
168Furrowed tongue (HP:0000221)0.87893122
169Hypermetropia (HP:0000540)0.87432974
170Progressive cerebellar ataxia (HP:0002073)0.87002383
171Amelogenesis imperfecta (HP:0000705)0.86764273
172Prominent nasal bridge (HP:0000426)0.84786020
173Facial hemangioma (HP:0000329)0.84164402
174Pancreatic cysts (HP:0001737)0.83599249
175Hirsutism (HP:0001007)0.83271048
176Polar cataract (HP:0010696)0.81733276
177Tongue fasciculations (HP:0001308)0.81335829
178Concave nail (HP:0001598)0.80765783
179Molar tooth sign on MRI (HP:0002419)0.80725298
180Abnormality of midbrain morphology (HP:0002418)0.80725298
181Chorioretinal coloboma (HP:0000567)0.79155980
182Clumsiness (HP:0002312)0.76960729
183Muscle fibrillation (HP:0010546)0.75898660
184Recurrent sinusitis (HP:0011108)0.75894507
185Aplasia/Hypoplasia of the macula (HP:0008059)0.75384498
186Aplasia/Hypoplasia of the tongue (HP:0010295)0.74248321
187Polycystic ovaries (HP:0000147)0.74158552
188Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.72521665
189Micropenis (HP:0000054)0.72357880
190Astrocytoma (HP:0009592)0.72003694
191Abnormality of the astrocytes (HP:0100707)0.72003694
192Lower limb hyperreflexia (HP:0002395)0.69411239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.71224456
2GRK16.34427430
3TRIB35.29855917
4ICK3.85059759
5PINK13.71469417
6WNK43.56317570
7SIK13.20163000
8MAPK152.80403701
9EEF2K2.63295846
10EPHA22.59387738
11DDR22.53073821
12ERN12.50607985
13SMG12.45042389
14IRAK22.44325109
15MAP3K62.39448832
16TESK22.35282129
17MUSK2.33108610
18SIK22.21173658
19BLK2.03853080
20PKN21.90398942
21MST1R1.84779882
22DYRK1B1.58269465
23PHKG11.56590618
24PHKG21.56590618
25UHMK11.56312170
26AKT31.53127992
27YES11.52804497
28CAMK1D1.43927744
29TYRO31.42966985
30MAP2K31.35822828
31PAK61.35604499
32GRK61.30370031
33PRKD21.26889714
34FGR1.26725237
35RPS6KA21.25357814
36IRAK31.25208548
37TTN1.20615253
38PDPK11.17983386
39NME21.17829948
40TLK11.17601942
41MAPKAPK31.16531717
42WNK11.10604685
43MATK1.09951753
44MAP3K111.09878894
45PRKCZ1.08129835
46NEK91.06214116
47MARK11.05557046
48HIPK21.03135440
49RPS6KA41.02396025
50PRKAA11.01858926
51BRD40.99777467
52STK390.99250108
53ARAF0.97026465
54MAP3K100.95733268
55ADRBK10.94715456
56PRPF4B0.93830464
57CSK0.93182733
58MKNK20.93094131
59TBK10.92873341
60CDK40.92628730
61MARK20.91572317
62CCNB10.91268397
63TAOK30.90287600
64PAK40.86227249
65MAPK120.82107034
66TAOK10.81880973
67RPS6KB20.81312407
68MAPK110.79416694
69CDK120.78985882
70BMX0.77866393
71MAPK70.76308070
72PDGFRA0.76099057
73PRKD10.73098129
74PRKAA20.70416069
75ZAP700.67463530
76MET0.67302622
77PRKD30.64989110
78CDC42BPA0.64719214
79MELK0.64551639
80NEK20.63620657
81TAOK20.62377151
82RIPK10.60810885
83CAMK2D0.60274095
84GSK3A0.59705904
85PRKACG0.59049017
86MAP3K40.57574071
87PTK20.57198755
88SGK4940.56618245
89SGK2230.56618245
90FGFR40.56553782
91PTK60.55654474
92NEK10.55357827
93CHEK20.55012224
94MAP2K60.54630491
95DYRK30.53441163
96RPS6KA30.53383680
97NTRK20.52843835
98DAPK10.52751481
99AURKA0.52539792
100DAPK30.52216044
101RPS6KC10.51821112
102RPS6KL10.51821112
103CAMK2A0.51452626
104CSNK1D0.51236901
105PDGFRB0.51223576
106CDK70.50800030
107CDK60.50666523
108TNK20.49357932
109STK160.49348855
110MAP4K10.48995933
111CDK150.48980769
112PRKCI0.48305800
113PIM20.47443204
114DYRK1A0.47091083
115MAPK90.45946003
116SGK30.45589647
117SCYL20.44660543
118CDK11A0.43950503
119MAPK140.43874995
120LMTK20.43468633
121CHUK0.43172274
122MAPK80.42823754
123PIM10.42752763
124CDK180.42163100
125SGK20.42149107
126INSRR0.41631573
127MTOR0.41398704
128RPS6KA60.41122552
129STK38L0.40108454
130CAMK1G0.39946280
131GSK3B0.39708579
132STK380.39431680
133MAPK100.38698088
134SGK10.38429882
135RPS6KB10.37665389
136MAP2K20.37432909
137PRKCH0.36692188
138MAP3K70.36331321
139NEK60.35795216
140CDK20.35530053
141PRKDC0.34516227
142CDK10.33804880
143LATS10.33345445
144CDK90.32947706
145MAPK30.32594101
146AKT20.31976203
147TESK10.31972064
148CHEK10.31180839
149MAP3K30.31055164
150ILK0.30705326
151LATS20.30284334
152ERBB30.30099823
153CAMKK10.29859710
154PAK20.29710711
155PAK30.29648784
156PRKCB0.29372043
157TRPM70.29288060
158NME10.29128935
159RPS6KA10.28863591
160PDK20.27957285
161DYRK20.27344953
162CAMK40.27121853

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006046.13262908
2Sulfur relay system_Homo sapiens_hsa041225.04103761
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.76523566
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.90315579
5Other glycan degradation_Homo sapiens_hsa005112.19838412
6Phototransduction_Homo sapiens_hsa0474415.9617603
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97864595
8Sphingolipid metabolism_Homo sapiens_hsa006001.74339308
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52326799
10Bladder cancer_Homo sapiens_hsa052191.45199964
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32611102
12Circadian rhythm_Homo sapiens_hsa047101.30209867
13Synaptic vesicle cycle_Homo sapiens_hsa047211.27121062
14Olfactory transduction_Homo sapiens_hsa047401.25978952
15VEGF signaling pathway_Homo sapiens_hsa043701.16943920
16Vitamin digestion and absorption_Homo sapiens_hsa049771.14808598
17GABAergic synapse_Homo sapiens_hsa047271.09977851
18Endometrial cancer_Homo sapiens_hsa052131.04980776
19Lysosome_Homo sapiens_hsa041420.93934920
20ECM-receptor interaction_Homo sapiens_hsa045120.89204764
21Chronic myeloid leukemia_Homo sapiens_hsa052200.88411584
22Melanogenesis_Homo sapiens_hsa049160.85012838
23Acute myeloid leukemia_Homo sapiens_hsa052210.84533459
24Fatty acid biosynthesis_Homo sapiens_hsa000610.84452898
25Small cell lung cancer_Homo sapiens_hsa052220.82811681
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79720164
27Cholinergic synapse_Homo sapiens_hsa047250.77289779
28Non-small cell lung cancer_Homo sapiens_hsa052230.76763486
29Focal adhesion_Homo sapiens_hsa045100.76670208
30Taste transduction_Homo sapiens_hsa047420.75927385
31N-Glycan biosynthesis_Homo sapiens_hsa005100.74514627
32Hepatitis C_Homo sapiens_hsa051600.74451260
33Insulin resistance_Homo sapiens_hsa049310.74111356
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73967978
35Fanconi anemia pathway_Homo sapiens_hsa034600.73713933
36Morphine addiction_Homo sapiens_hsa050320.73536652
37Endocytosis_Homo sapiens_hsa041440.73294809
38Dopaminergic synapse_Homo sapiens_hsa047280.71664726
39Neurotrophin signaling pathway_Homo sapiens_hsa047220.69951450
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69500296
41Retinol metabolism_Homo sapiens_hsa008300.68744193
42Base excision repair_Homo sapiens_hsa034100.67904266
43Ovarian steroidogenesis_Homo sapiens_hsa049130.66540014
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.64279603
45B cell receptor signaling pathway_Homo sapiens_hsa046620.63700494
46Circadian entrainment_Homo sapiens_hsa047130.62290005
47mTOR signaling pathway_Homo sapiens_hsa041500.59674649
48Fructose and mannose metabolism_Homo sapiens_hsa000510.57195345
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55642109
50Proteoglycans in cancer_Homo sapiens_hsa052050.55608435
51Glutamatergic synapse_Homo sapiens_hsa047240.55228924
52Serotonergic synapse_Homo sapiens_hsa047260.54675080
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53539716
54Pyruvate metabolism_Homo sapiens_hsa006200.52233756
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51784858
56Biosynthesis of amino acids_Homo sapiens_hsa012300.51118238
57Prostate cancer_Homo sapiens_hsa052150.50917056
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49955261
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.49151453
60Thyroid cancer_Homo sapiens_hsa052160.49099116
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.48323741
62HTLV-I infection_Homo sapiens_hsa051660.47369318
63Apoptosis_Homo sapiens_hsa042100.46733618
64Pancreatic cancer_Homo sapiens_hsa052120.45742612
65Hippo signaling pathway_Homo sapiens_hsa043900.45405852
66Notch signaling pathway_Homo sapiens_hsa043300.44023440
67mRNA surveillance pathway_Homo sapiens_hsa030150.43977874
68Calcium signaling pathway_Homo sapiens_hsa040200.43847646
69Mismatch repair_Homo sapiens_hsa034300.43750516
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42824467
71Lysine degradation_Homo sapiens_hsa003100.41607100
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41264589
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39870187
74Influenza A_Homo sapiens_hsa051640.39458587
75Axon guidance_Homo sapiens_hsa043600.39269505
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39036457
77Galactose metabolism_Homo sapiens_hsa000520.38197782
78ABC transporters_Homo sapiens_hsa020100.38163735
79Viral carcinogenesis_Homo sapiens_hsa052030.37738444
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.37698729
81Arginine biosynthesis_Homo sapiens_hsa002200.37243163
82MicroRNAs in cancer_Homo sapiens_hsa052060.37013119
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36471930
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35506735
85Oxytocin signaling pathway_Homo sapiens_hsa049210.35234712
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35066561
87Cardiac muscle contraction_Homo sapiens_hsa042600.34900999
88Dilated cardiomyopathy_Homo sapiens_hsa054140.34825538
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34646539
90Toxoplasmosis_Homo sapiens_hsa051450.34150145
91Systemic lupus erythematosus_Homo sapiens_hsa053220.34014844
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33892390
93Pathways in cancer_Homo sapiens_hsa052000.33861603
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33684667
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33566352
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33230877
97Hedgehog signaling pathway_Homo sapiens_hsa043400.33132247
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32116277
99Insulin secretion_Homo sapiens_hsa049110.31929141
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.31430053
101Platelet activation_Homo sapiens_hsa046110.31283523
102Thyroid hormone synthesis_Homo sapiens_hsa049180.30895127
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.29442384
104Nicotine addiction_Homo sapiens_hsa050330.29113150
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28771625
106Fatty acid elongation_Homo sapiens_hsa000620.27922351
107AMPK signaling pathway_Homo sapiens_hsa041520.25960059
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25272377
109Glycerolipid metabolism_Homo sapiens_hsa005610.25236917
110Wnt signaling pathway_Homo sapiens_hsa043100.25119539
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24126129
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23910913
113Purine metabolism_Homo sapiens_hsa002300.23680933
114Glucagon signaling pathway_Homo sapiens_hsa049220.23613784
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21368058
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21367701
117ErbB signaling pathway_Homo sapiens_hsa040120.21319518
118Arginine and proline metabolism_Homo sapiens_hsa003300.21159710
119HIF-1 signaling pathway_Homo sapiens_hsa040660.19006298
120Spliceosome_Homo sapiens_hsa030400.18894958
121Inositol phosphate metabolism_Homo sapiens_hsa005620.18781687
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18771380
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18596612
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18331015
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17974969
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.17827950
127Alcoholism_Homo sapiens_hsa050340.17421288
128Chemokine signaling pathway_Homo sapiens_hsa040620.16975125
129cAMP signaling pathway_Homo sapiens_hsa040240.16837634
130Tight junction_Homo sapiens_hsa045300.16500562
131Fatty acid metabolism_Homo sapiens_hsa012120.16151379
132Ras signaling pathway_Homo sapiens_hsa040140.14070380
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14002113
134Insulin signaling pathway_Homo sapiens_hsa049100.13906990
135RNA transport_Homo sapiens_hsa030130.13380265
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12921032
137MAPK signaling pathway_Homo sapiens_hsa040100.12543173
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.11930341
139GnRH signaling pathway_Homo sapiens_hsa049120.11755290
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11620935
141Basal cell carcinoma_Homo sapiens_hsa052170.11471682
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11368588
143TGF-beta signaling pathway_Homo sapiens_hsa043500.11349382
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10104121
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10063200
146RNA degradation_Homo sapiens_hsa030180.10052302
147Adherens junction_Homo sapiens_hsa045200.09778578
148Renin secretion_Homo sapiens_hsa049240.09547814
149Fat digestion and absorption_Homo sapiens_hsa049750.09088001
150Colorectal cancer_Homo sapiens_hsa052100.08170392
151Oocyte meiosis_Homo sapiens_hsa041140.08089731
152Choline metabolism in cancer_Homo sapiens_hsa052310.07423290
153Type II diabetes mellitus_Homo sapiens_hsa049300.06977861
154Gap junction_Homo sapiens_hsa045400.06367091
155Folate biosynthesis_Homo sapiens_hsa007900.05867852
156Viral myocarditis_Homo sapiens_hsa054160.05608354
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04852240
158Mineral absorption_Homo sapiens_hsa049780.04568996
159Nucleotide excision repair_Homo sapiens_hsa034200.04489508

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