FSD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.14475616
2cardiac myofibril assembly (GO:0055003)8.47841384
3actin-myosin filament sliding (GO:0033275)8.17476619
4muscle filament sliding (GO:0030049)8.17476619
5myofibril assembly (GO:0030239)7.95587145
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.83462114
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.11954804
8negative regulation of potassium ion transmembrane transport (GO:1901380)6.99646010
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.86197578
10regulation of skeletal muscle contraction (GO:0014819)6.79554785
11actin-mediated cell contraction (GO:0070252)6.77289383
12cardiac muscle contraction (GO:0060048)6.75159997
13tricarboxylic acid cycle (GO:0006099)6.53211198
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.45778944
15cardiac muscle cell development (GO:0055013)6.25472342
16regulation of relaxation of muscle (GO:1901077)6.17123897
17plasma membrane repair (GO:0001778)6.04594420
18regulation of actin filament-based movement (GO:1903115)5.96331526
19cardiac cell development (GO:0055006)5.87834381
20sarcoplasmic reticulum calcium ion transport (GO:0070296)5.86706688
21actomyosin structure organization (GO:0031032)5.86129199
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.72459513
23striated muscle contraction (GO:0006941)5.71298216
24cardiac muscle tissue morphogenesis (GO:0055008)5.67887702
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.67439088
26carnitine shuttle (GO:0006853)5.66187288
27regulation of cell communication by electrical coupling (GO:0010649)5.47928068
28cardiac muscle hypertrophy (GO:0003300)5.43326286
29regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.41748195
30adult heart development (GO:0007512)5.39413950
31ventricular cardiac muscle cell action potential (GO:0086005)5.35966235
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.31622912
33heart contraction (GO:0060047)5.31551826
34heart process (GO:0003015)5.31551826
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.29661125
36regulation of sarcomere organization (GO:0060297)5.29313007
37striated muscle hypertrophy (GO:0014897)5.20694264
38regulation of acyl-CoA biosynthetic process (GO:0050812)5.20640471
39muscle tissue morphogenesis (GO:0060415)5.12473461
40bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06979996
41actin filament-based movement (GO:0030048)5.06715094
42regulation of striated muscle contraction (GO:0006942)4.98776341
43fatty acid transmembrane transport (GO:1902001)4.94632533
44heart trabecula formation (GO:0060347)4.88648469
45regulation of cofactor metabolic process (GO:0051193)4.75490269
46regulation of coenzyme metabolic process (GO:0051196)4.75490269
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.68373572
48response to muscle activity (GO:0014850)4.65743401
49muscle hypertrophy (GO:0014896)4.61396214
50regulation of membrane repolarization (GO:0060306)4.51978839
51regulation of the force of heart contraction (GO:0002026)4.51012735
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.40723190
53skeletal muscle contraction (GO:0003009)4.37406387
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29367363
55cell communication involved in cardiac conduction (GO:0086065)4.28574838
56creatine metabolic process (GO:0006600)4.19805682
57carnitine transmembrane transport (GO:1902603)4.18290544
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99965687
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.99965687
60NADH dehydrogenase complex assembly (GO:0010257)3.99965687
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99487881
62NADH metabolic process (GO:0006734)3.96541511
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95613321
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.95396219
65oxidative phosphorylation (GO:0006119)3.95316489
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94866048
67ATP synthesis coupled proton transport (GO:0015986)3.94866048
68regulation of cardiac muscle contraction (GO:0055117)3.90737646
69respiratory electron transport chain (GO:0022904)3.89702413
70ubiquinone biosynthetic process (GO:0006744)3.89373441
71cardiac muscle adaptation (GO:0014887)3.87279061
72cardiac muscle hypertrophy in response to stress (GO:0014898)3.87279061
73muscle hypertrophy in response to stress (GO:0003299)3.87279061
74muscle contraction (GO:0006936)3.86885893
75regulation of sulfur metabolic process (GO:0042762)3.85660958
76cardiac muscle cell action potential involved in contraction (GO:0086002)3.84212446
77muscle fiber development (GO:0048747)3.83825502
782-oxoglutarate metabolic process (GO:0006103)3.83081446
79negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.82983989
80cardiac muscle cell action potential (GO:0086001)3.81491166
81regulation of cardiac muscle cell contraction (GO:0086004)3.81289567
82regulation of heart rate (GO:0002027)3.81101800
83carnitine transport (GO:0015879)3.80440026
84amino-acid betaine transport (GO:0015838)3.80440026
85striated muscle cell development (GO:0055002)3.80305429
86myotube cell development (GO:0014904)3.80271298
87response to inactivity (GO:0014854)3.79885365
88skeletal muscle adaptation (GO:0043501)3.78981628
89electron transport chain (GO:0022900)3.77966252
90negative regulation of potassium ion transport (GO:0043267)3.77630478
91skeletal muscle fiber development (GO:0048741)3.75397409
92regulation of ATPase activity (GO:0043462)3.75286399
93regulation of ATP catabolic process (GO:1903289)3.75286399
94cell communication by electrical coupling (GO:0010644)3.75260926
95regulation of sequestering of triglyceride (GO:0010889)3.73543387
96negative regulation of protein localization to cell surface (GO:2000009)3.71785840
97striated muscle adaptation (GO:0014888)3.66085403
98relaxation of cardiac muscle (GO:0055119)3.65452853
99protein complex biogenesis (GO:0070271)3.62357069
100muscle system process (GO:0003012)3.61064366
101negative regulation of striated muscle cell apoptotic process (GO:0010664)3.58352033
102regulation of cardioblast differentiation (GO:0051890)3.52690041
103ubiquinone metabolic process (GO:0006743)3.50371603
104regulation of heart contraction (GO:0008016)3.48295459
105regulation of calcium ion transmembrane transporter activity (GO:1901019)3.46120730
106regulation of calcium ion transmembrane transport (GO:1903169)3.46120730
107positive regulation of cation channel activity (GO:2001259)3.45496800
108regulation of muscle contraction (GO:0006937)3.39649952
109mitochondrial respiratory chain complex assembly (GO:0033108)3.35330582
110cardiac conduction (GO:0061337)3.35131876
111glycogen catabolic process (GO:0005980)3.34734294
112ventricular cardiac muscle cell development (GO:0055015)3.31597311
113negative regulation of calcium ion transmembrane transport (GO:1903170)3.30704979
114negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.30704979
115response to caffeine (GO:0031000)3.25608023
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18635204
117regulation of glucokinase activity (GO:0033131)3.18349429
118regulation of hexokinase activity (GO:1903299)3.18349429
119skeletal muscle tissue development (GO:0007519)3.18155988
120negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.12279710
121relaxation of muscle (GO:0090075)3.06160239
122quinone biosynthetic process (GO:1901663)3.04720694
123otic vesicle formation (GO:0030916)3.04647264
124glycogen biosynthetic process (GO:0005978)3.00812066
125glucan biosynthetic process (GO:0009250)3.00812066
126glucan catabolic process (GO:0009251)2.97752024
127striated muscle atrophy (GO:0014891)2.95591187
128adenosine metabolic process (GO:0046085)2.87253160
129behavioral response to nicotine (GO:0035095)2.81783799
130cellular polysaccharide catabolic process (GO:0044247)2.78391374
131muscle atrophy (GO:0014889)2.75286834
132muscle structure development (GO:0061061)2.73553572
133skeletal muscle tissue regeneration (GO:0043403)2.71512444
134respiratory chain complex IV assembly (GO:0008535)2.71031228
135aspartate family amino acid catabolic process (GO:0009068)2.69630422
136muscle organ development (GO:0007517)2.69160835
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66258845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.58786552
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.10260752
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.95763368
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.65666383
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.38172714
6* TBX20_22328084_ChIP-Seq_HEART_Mouse4.21416781
7* TBX20_22080862_ChIP-Seq_HEART_Mouse4.21416781
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61205257
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.58109667
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.42549363
11VDR_22108803_ChIP-Seq_LS180_Human3.37256342
12* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.21622019
13ZNF263_19887448_ChIP-Seq_K562_Human3.11616567
14GBX2_23144817_ChIP-Seq_PC3_Human2.95697901
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93299875
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92383794
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88222199
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.79520698
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63450836
20* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.57590894
21IGF1R_20145208_ChIP-Seq_DFB_Human2.47928795
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43141769
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37563593
24FUS_26573619_Chip-Seq_HEK293_Human2.29607175
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28337229
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19484817
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11336214
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.08486415
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04675035
30TAF15_26573619_Chip-Seq_HEK293_Human2.04066131
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02052760
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01043597
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97407954
34* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90521212
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88336761
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87883153
37PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.86321447
38* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.85641597
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85117955
40EWS_26573619_Chip-Seq_HEK293_Human1.84394304
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83769108
42ER_23166858_ChIP-Seq_MCF-7_Human1.80384360
43CLOCK_20551151_ChIP-Seq_293T_Human1.78322919
44EZH2_22144423_ChIP-Seq_EOC_Human1.74502503
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69003117
46P300_19829295_ChIP-Seq_ESCs_Human1.60045343
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.58518257
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58335208
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58323101
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56453008
51CBP_20019798_ChIP-Seq_JUKART_Human1.55769115
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55769115
53GATA1_22025678_ChIP-Seq_K562_Human1.55373085
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52858404
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.52156547
56SOX2_19829295_ChIP-Seq_ESCs_Human1.47627642
57NANOG_19829295_ChIP-Seq_ESCs_Human1.47627642
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47356272
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.47113609
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44285377
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.42242939
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.41713986
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41568328
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41097460
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.40480617
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39641419
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.39048896
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37878314
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37824790
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37720805
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37443744
72SMAD4_21799915_ChIP-Seq_A2780_Human1.36541295
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36445518
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35103133
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32290029
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29552397
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28384797
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26276869
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26129459
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25993498
81TP53_22573176_ChIP-Seq_HFKS_Human1.25931586
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.25111834
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.24958094
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.24029106
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23525742
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.23389235
87ELK1_19687146_ChIP-ChIP_HELA_Human1.23115897
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21588600
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21183525
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21005110
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20820253
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20299897
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.19680311
94VDR_23849224_ChIP-Seq_CD4+_Human1.18973018
95STAT3_23295773_ChIP-Seq_U87_Human1.18769361
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.18736207
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17964771
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16269911
99TCF4_23295773_ChIP-Seq_U87_Human1.16265395
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15463376
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15290518
102CTCF_27219007_Chip-Seq_Bcells_Human1.14813363
103AR_25329375_ChIP-Seq_VCAP_Human1.14398135
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13021563
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12807736
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12780351
107AR_21572438_ChIP-Seq_LNCaP_Human1.12036509
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11963935
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11403351
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.10588338
111KDM2B_26808549_Chip-Seq_DND41_Human1.09408137
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07080755
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07025728
114TP63_22573176_ChIP-Seq_HFKS_Human1.07022047
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05236258
116* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05147509
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.05144645
118MYC_18940864_ChIP-ChIP_HL60_Human1.04579049
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.04227064
120NCOR_22424771_ChIP-Seq_293T_Human1.03863058
121PHF8_20622853_ChIP-Seq_HELA_Human1.03528440
122DROSHA_22980978_ChIP-Seq_HELA_Human1.02896705
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01922369
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01036948
125P53_22387025_ChIP-Seq_ESCs_Mouse0.99567196
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98527031
127HOXB7_26014856_ChIP-Seq_BT474_Human0.97943777
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97581801
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97495235
130ZNF274_21170338_ChIP-Seq_K562_Hela0.96967924
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96528320
132* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96315342
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.95571457
134AR_20517297_ChIP-Seq_VCAP_Human0.95301679
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94997628
136ATF3_27146783_Chip-Seq_COLON_Human0.94649699
137RXR_22158963_ChIP-Seq_LIVER_Mouse0.94537697
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94226499
139SPI1_20517297_ChIP-Seq_HL60_Human0.94154042
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93938674
141* GATA1_19941826_ChIP-Seq_K562_Human0.93885378
142IRF1_19129219_ChIP-ChIP_H3396_Human0.93787380
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.93672068
144NFYB_21822215_ChIP-Seq_K562_Human0.93484606
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.93462641
146ETV1_20927104_ChIP-Seq_GIST48_Human0.93054544
147HTT_18923047_ChIP-ChIP_STHdh_Human0.93013421
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92631068
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92267889
150SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92088648
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90124798
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89269145
153CJUN_26792858_Chip-Seq_BT549_Human0.88676595
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.87989963
155RACK7_27058665_Chip-Seq_MCF-7_Human0.86933872
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86843812
157FOXH1_21741376_ChIP-Seq_ESCs_Human0.86509372
158P68_20966046_ChIP-Seq_HELA_Human0.85064612
159FOXA2_19822575_ChIP-Seq_HepG2_Human0.84773627
160* OCT4_20526341_ChIP-Seq_ESCs_Human0.84682990
161LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83579368
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82787980
163* GATA2_19941826_ChIP-Seq_K562_Human0.80847130
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80548744
165LXR_22292898_ChIP-Seq_THP-1_Human0.79561243
166TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78067218
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.77298612
168SMAD3_21741376_ChIP-Seq_HESCs_Human0.77248582
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76986407
170BCAT_22108803_ChIP-Seq_LS180_Human0.76061282
171CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76038759
172ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76025788
173CTCF_21964334_Chip-Seq_Bcells_Human0.75158049
174SOX2_21211035_ChIP-Seq_LN229_Gbm0.75134349
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75059005
176GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74224362
177EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.74141929
178UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72580475
179SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72037856
180SMC1_22415368_ChIP-Seq_MEFs_Mouse0.71916082
181BCL6_27268052_Chip-Seq_Bcells_Human0.71387098
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.71141978
183ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71127597
184BCOR_27268052_Chip-Seq_Bcells_Human0.70498823
185TDRD3_21172665_ChIP-Seq_MCF-7_Human0.70363207
186TP53_23651856_ChIP-Seq_MEFs_Mouse0.69986433
187ESR1_21235772_ChIP-Seq_MCF-7_Human0.69776127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.53383036
2MP0003646_muscle_fatigue5.84761516
3MP0004084_abnormal_cardiac_muscle5.55236610
4MP0000751_myopathy5.14914502
5MP0004215_abnormal_myocardial_fiber4.49863707
6MP0004036_abnormal_muscle_relaxation4.49583372
7MP0000749_muscle_degeneration4.38492297
8MP0005330_cardiomyopathy3.78491385
9MP0004087_abnormal_muscle_fiber3.24144321
10MP0004145_abnormal_muscle_electrophysio3.21758147
11MP0002972_abnormal_cardiac_muscle3.06893212
12MP0005620_abnormal_muscle_contractility2.91718313
13MP0004130_abnormal_muscle_cell2.84761861
14MP0002106_abnormal_muscle_physiology2.84633869
15MP0000750_abnormal_muscle_regeneration2.81632196
16MP0008775_abnormal_heart_ventricle2.79558862
17MP0003137_abnormal_impulse_conducting2.70134120
18MP0010630_abnormal_cardiac_muscle2.54666841
19MP0002269_muscular_atrophy2.52924784
20MP0001544_abnormal_cardiovascular_syste2.51997933
21MP0005385_cardiovascular_system_phenoty2.51997933
22MP0004484_altered_response_of2.40724306
23MP0005369_muscle_phenotype2.30253092
24MP0000747_muscle_weakness2.29815478
25MP0006138_congestive_heart_failure2.26695320
26MP0000759_abnormal_skeletal_muscle2.25984748
27MP0003828_pulmonary_edema2.21954563
28MP0003221_abnormal_cardiomyocyte_apopto2.01082073
29MP0004085_abnormal_heartbeat1.95824306
30MP0004510_myositis1.89979189
31MP0004233_abnormal_muscle_weight1.86231610
32MP0006036_abnormal_mitochondrial_physio1.85575192
33MP0002127_abnormal_cardiovascular_syste1.60157240
34MP0002332_abnormal_exercise_endurance1.57518693
35MP0005666_abnormal_adipose_tissue1.57027375
36MP0003950_abnormal_plasma_membrane1.55245376
37MP0005670_abnormal_white_adipose1.47328850
38MP0000372_irregular_coat_pigmentation1.45978584
39MP0003567_abnormal_fetal_cardiomyocyte1.29489724
40MP0006072_abnormal_retinal_apoptosis1.26981404
41MP0002163_abnormal_gland_morphology1.25932633
42MP0004185_abnormal_adipocyte_glucose1.18301645
43MP0000343_altered_response_to1.14886833
44MP0002638_abnormal_pupillary_reflex1.14247655
45MP0004142_abnormal_muscle_tone1.14006299
46MP0000266_abnormal_heart_morphology1.11511110
47MP0006035_abnormal_mitochondrial_morpho1.08597773
48MP0005375_adipose_tissue_phenotype1.06168284
49MP0000569_abnormal_digit_pigmentation1.03649456
50MP0005253_abnormal_eye_physiology1.03038464
51MP0005551_abnormal_eye_electrophysiolog1.00148468
52MP0001661_extended_life_span0.99678889
53MP0008877_abnormal_DNA_methylation0.98984639
54MP0002108_abnormal_muscle_morphology0.98907878
55MP0002234_abnormal_pharynx_morphology0.97004572
56MP0005165_increased_susceptibility_to0.96188404
57MP0010368_abnormal_lymphatic_system0.93509362
58MP0005645_abnormal_hypothalamus_physiol0.92361099
59MP0003279_aneurysm0.91095728
60MP0002102_abnormal_ear_morphology0.90295988
61MP0005266_abnormal_metabolism0.87464944
62MP0004270_analgesia0.87024293
63MP0008872_abnormal_physiological_respon0.86723389
64MP0009046_muscle_twitch0.83943545
65MP0003195_calcinosis0.80065978
66MP0000733_abnormal_muscle_development0.79428964
67MP0004134_abnormal_chest_morphology0.77158120
68MP0002160_abnormal_reproductive_system0.77141331
69MP0000230_abnormal_systemic_arterial0.75805591
70MP0003806_abnormal_nucleotide_metabolis0.74881953
71MP0002272_abnormal_nervous_system0.74113496
72MP0002128_abnormal_blood_circulation0.73705706
73MP0005646_abnormal_pituitary_gland0.73617526
74MP0002971_abnormal_brown_adipose0.72756116
75MP0005379_endocrine/exocrine_gland_phen0.69923740
76MP0002876_abnormal_thyroid_physiology0.69538170
77MP0000631_abnormal_neuroendocrine_gland0.69250769
78MP0003705_abnormal_hypodermis_morpholog0.68347102
79MP0003566_abnormal_cell_adhesion0.67479506
80MP0005451_abnormal_body_composition0.66749878
81MP0005332_abnormal_amino_acid0.66608664
82MP0001485_abnormal_pinna_reflex0.65099310
83MP0001984_abnormal_olfaction0.64816449
84MP0006276_abnormal_autonomic_nervous0.64114001
85MP0008058_abnormal_DNA_repair0.62834478
86MP0000013_abnormal_adipose_tissue0.61521334
87MP0000003_abnormal_adipose_tissue0.60894758
88MP0003136_yellow_coat_color0.60849787
89MP0001529_abnormal_vocalization0.59035083
90MP0001986_abnormal_taste_sensitivity0.58776872
91MP0004147_increased_porphyrin_level0.58278643
92MP0009745_abnormal_behavioral_response0.58205791
93MP0004043_abnormal_pH_regulation0.57214943
94MP0002938_white_spotting0.57131406
95MP0001879_abnormal_lymphatic_vessel0.56813610
96MP0005623_abnormal_meninges_morphology0.53573811
97MP0002822_catalepsy0.51887008
98MP0009697_abnormal_copulation0.51399911
99MP0002078_abnormal_glucose_homeostasis0.51258054
100MP0002909_abnormal_adrenal_gland0.51044957
101MP0000767_abnormal_smooth_muscle0.50915066
102MP0004272_abnormal_basement_membrane0.50398527
103MP0005167_abnormal_blood-brain_barrier0.49987257
104MP0009250_abnormal_appendicular_skeleto0.49222319
105MP0001486_abnormal_startle_reflex0.48786937
106MP0008438_abnormal_cutaneous_collagen0.48067983
107MP0005319_abnormal_enzyme/_coenzyme0.47284963
108MP0005275_abnormal_skin_tensile0.45496055
109MP0002067_abnormal_sensory_capabilities0.44830749
110MP0004885_abnormal_endolymph0.43514213
111MP0002925_abnormal_cardiovascular_devel0.43149026
112MP0008961_abnormal_basal_metabolism0.42446938
113MP0005389_reproductive_system_phenotype0.42410316
114MP0005423_abnormal_somatic_nervous0.41610771
115MP0001502_abnormal_circadian_rhythm0.41300542
116MP0005334_abnormal_fat_pad0.40649366
117MP0005187_abnormal_penis_morphology0.39752433
118MP0003984_embryonic_growth_retardation0.38388555
119MP0002088_abnormal_embryonic_growth/wei0.37522501
120MP0005535_abnormal_body_temperature0.35986681
121MP0001784_abnormal_fluid_regulation0.34005161
122MP0003948_abnormal_gas_homeostasis0.33809237
123MP0009115_abnormal_fat_cell0.33525797
124MP0001614_abnormal_blood_vessel0.33204359
125MP0009384_cardiac_valve_regurgitation0.31586702
126MP0002118_abnormal_lipid_homeostasis0.27030892
127MP0001727_abnormal_embryo_implantation0.26911936
128MP0005452_abnormal_adipose_tissue0.25382911
129MP0005584_abnormal_enzyme/coenzyme_acti0.24883770
130MP0003045_fibrosis0.23434095
131MP0005595_abnormal_vascular_smooth0.22164593
132MP0002970_abnormal_white_adipose0.21839238
133MP0004924_abnormal_behavior0.18979400
134MP0005386_behavior/neurological_phenoty0.18979400
135MP0005376_homeostasis/metabolism_phenot0.18774787
136MP0001853_heart_inflammation0.18484237
137MP0000249_abnormal_blood_vessel0.17984447
138MP0001672_abnormal_embryogenesis/_devel0.17899768
139MP0005380_embryogenesis_phenotype0.17899768
140MP0009780_abnormal_chondrocyte_physiolo0.15771294
141MP0005388_respiratory_system_phenotype0.15253203
142MP0002133_abnormal_respiratory_system0.15253203
143MP0003656_abnormal_erythrocyte_physiolo0.14165376

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.70737112
2Exercise-induced muscle cramps (HP:0003710)6.82062084
3Exercise-induced myalgia (HP:0003738)6.78657761
4Calf muscle hypertrophy (HP:0008981)6.77695236
5Ventricular tachycardia (HP:0004756)6.56031374
6Muscle hypertrophy of the lower extremities (HP:0008968)6.49453080
7Muscle fiber splitting (HP:0003555)5.76530809
8Atrial fibrillation (HP:0005110)5.56077605
9Myoglobinuria (HP:0002913)5.38425074
10Abnormality of the calf musculature (HP:0001430)5.30491906
11Subaortic stenosis (HP:0001682)5.22811313
12Abnormality of the left ventricular outflow tract (HP:0011103)5.22811313
13Primary atrial arrhythmia (HP:0001692)5.19140189
14Hyporeflexia of lower limbs (HP:0002600)5.12126943
15Lipoatrophy (HP:0100578)5.10460774
16Supraventricular tachycardia (HP:0004755)5.01780049
17Supraventricular arrhythmia (HP:0005115)4.91651456
18Right ventricular cardiomyopathy (HP:0011663)4.58072108
19EMG: myopathic abnormalities (HP:0003458)4.45149597
20Syncope (HP:0001279)4.37383155
21Rhabdomyolysis (HP:0003201)4.27534994
22Dilated cardiomyopathy (HP:0001644)4.25474369
23Bundle branch block (HP:0011710)4.20038446
24Palpitations (HP:0001962)4.13511271
25Increased connective tissue (HP:0009025)4.12163056
26Asymmetric septal hypertrophy (HP:0001670)4.05726408
27Difficulty running (HP:0009046)4.03423399
28Prolonged QT interval (HP:0001657)3.95908532
29Muscle fiber inclusion bodies (HP:0100299)3.85181234
30Ventricular arrhythmia (HP:0004308)3.81888749
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.77080609
32Myotonia (HP:0002486)3.71430503
33Type 1 muscle fiber predominance (HP:0003803)3.55757311
34Heart block (HP:0012722)3.52866139
35Absent phalangeal crease (HP:0006109)3.35857478
36Atrioventricular block (HP:0001678)3.33385631
37Abnormal atrioventricular conduction (HP:0005150)3.31724939
38Ventricular fibrillation (HP:0001663)3.31382829
39Muscle stiffness (HP:0003552)3.15458257
40Nemaline bodies (HP:0003798)3.12851641
41Ulnar deviation of the wrist (HP:0003049)3.07850568
42Difficulty climbing stairs (HP:0003551)3.01048166
43Abnormal EKG (HP:0003115)2.87584141
44Abnormal finger flexion creases (HP:0006143)2.85839676
45Left ventricular hypertrophy (HP:0001712)2.83642570
46Abnormal mitochondria in muscle tissue (HP:0008316)2.81902474
47Hepatic necrosis (HP:0002605)2.81220310
48Calcaneovalgus deformity (HP:0001848)2.80677404
49Frequent falls (HP:0002359)2.78231416
50Neck muscle weakness (HP:0000467)2.76246196
51Acute necrotizing encephalopathy (HP:0006965)2.75435939
52Increased variability in muscle fiber diameter (HP:0003557)2.70266990
53Areflexia of lower limbs (HP:0002522)2.69502598
54Distal lower limb muscle weakness (HP:0009053)2.65195293
55Abnormality of skeletal muscle fiber size (HP:0012084)2.61896598
56Ketoacidosis (HP:0001993)2.54875135
57Deformed tarsal bones (HP:0008119)2.51965090
58Palmoplantar keratoderma (HP:0000982)2.49312320
59Rimmed vacuoles (HP:0003805)2.47528038
60Hypoglycemic coma (HP:0001325)2.44817451
61Hepatocellular necrosis (HP:0001404)2.41624985
62Malignant hyperthermia (HP:0002047)2.37862878
63Acute encephalopathy (HP:0006846)2.37225929
64Increased muscle lipid content (HP:0009058)2.34286256
65Progressive macrocephaly (HP:0004481)2.29034816
66Abnormality of fatty-acid metabolism (HP:0004359)2.26409468
67Limb-girdle muscle atrophy (HP:0003797)2.26317853
68Ragged-red muscle fibers (HP:0003200)2.25409294
69Conjunctival hamartoma (HP:0100780)2.25206085
70Mitochondrial inheritance (HP:0001427)2.24810608
71Dicarboxylic aciduria (HP:0003215)2.22090913
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22090913
73Exercise intolerance (HP:0003546)2.21978897
74Increased CSF lactate (HP:0002490)2.18313335
75Cerebral edema (HP:0002181)2.18213322
76Hypoplastic ischia (HP:0003175)2.17266030
77Fetal akinesia sequence (HP:0001989)2.16117269
78Hyperkalemia (HP:0002153)2.16109393
79EMG: neuropathic changes (HP:0003445)2.15646639
80Distal arthrogryposis (HP:0005684)2.14750918
81Muscular dystrophy (HP:0003560)2.09859720
82Generalized muscle weakness (HP:0003324)2.09783108
83Testicular atrophy (HP:0000029)2.09027988
84Myopathic facies (HP:0002058)2.06758275
85Round ear (HP:0100830)2.02488236
86Increased intramyocellular lipid droplets (HP:0012240)2.01621354
87Mildly elevated creatine phosphokinase (HP:0008180)2.01461183
88Abnormality of alanine metabolism (HP:0010916)2.01265655
89Hyperalaninemia (HP:0003348)2.01265655
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01265655
91Abnormality of the foot musculature (HP:0001436)2.00155780
92Lactic acidosis (HP:0003128)1.98647487
93Pheochromocytoma (HP:0002666)1.97768761
94Progressive muscle weakness (HP:0003323)1.96494610
95Sudden cardiac death (HP:0001645)1.93923939
96Congestive heart failure (HP:0001635)1.92257803
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.90556005
98Gowers sign (HP:0003391)1.90048696
99Facial diplegia (HP:0001349)1.89996175
1003-Methylglutaconic aciduria (HP:0003535)1.89742150
101Abnormality of the ischium (HP:0003174)1.89164665
102Ketosis (HP:0001946)1.89125277
103Respiratory failure (HP:0002878)1.88970624
104Foot dorsiflexor weakness (HP:0009027)1.87931022
105Type II lissencephaly (HP:0007260)1.87573429
106Distal lower limb amyotrophy (HP:0008944)1.86997455
107Scapular winging (HP:0003691)1.86223385
108Abnormality of the shoulder girdle musculature (HP:0001435)1.84785479
109Large for gestational age (HP:0001520)1.82039242
110Paralysis (HP:0003470)1.80950211
111Hamartoma of the eye (HP:0010568)1.80657856
112Proximal amyotrophy (HP:0007126)1.79575657
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78466266
114Neuroendocrine neoplasm (HP:0100634)1.78374797
115Fatigable weakness (HP:0003473)1.76850726
116Abnormality of the neuromuscular junction (HP:0003398)1.76850726
117Type 2 muscle fiber atrophy (HP:0003554)1.76097721
118Weak cry (HP:0001612)1.74965210
119Pancreatic cysts (HP:0001737)1.73825987
120Hip contracture (HP:0003273)1.73168121
121Abnormality of the renal cortex (HP:0011035)1.72520903
122Methylmalonic acidemia (HP:0002912)1.71587368
123Increased serum lactate (HP:0002151)1.67262595
124Long clavicles (HP:0000890)1.64394254
125Cerebellar dysplasia (HP:0007033)1.63260285
126Renal cortical cysts (HP:0000803)1.61938591
127Nephronophthisis (HP:0000090)1.60976750
128Abnormality of the pons (HP:0007361)1.60918450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.93380137
2OBSCN5.82908091
3PHKG24.43675653
4PHKG14.43675653
5PDK33.47642377
6PDK43.47642377
7MYLK3.40383994
8LMTK23.27822187
9DMPK2.94726399
10PKN22.86501272
11FRK2.78045035
12TRIB32.53227374
13NEK12.49442224
14BCKDK2.44543218
15PIK3CA2.41372438
16STK242.27283051
17PDK22.10359715
18MUSK2.00219479
19MAP4K21.99067041
20PINK11.97848110
21TIE11.86624357
22TLK11.55776004
23BMPR1B1.48017992
24NUAK11.37692580
25EIF2AK31.35619972
26GRK71.31960482
27ADRBK21.31628570
28MAP3K71.27221825
29WNK31.24482869
30ACVR1B1.23999311
31ZAK1.22483451
32MAP2K31.21254400
33ILK1.21140660
34PAK31.13916514
35PRKD11.13326391
36MAPK121.13118915
37CAMK2D1.10925444
38GRK11.09885782
39CCNB11.07006104
40ERBB31.06927446
41VRK11.04927190
42TRPM70.97454189
43MAPK130.97010822
44NME10.96976321
45PRKAA20.94020091
46CDC42BPA0.93001636
47PRKAA10.92852136
48MAP3K40.92290325
49STK38L0.90949858
50ROCK10.89419103
51STK40.85507514
52DAPK20.84345945
53FLT30.83917942
54INSRR0.81950339
55MARK10.81178969
56MAPKAPK30.79761358
57BRSK20.78372876
58RIPK10.77886304
59MAP3K50.77608137
60WNK40.76109769
61STK160.74315121
62MKNK20.70058608
63PKN10.68634508
64TNIK0.67957655
65MAP3K30.67912125
66PIK3CG0.65520086
67NEK90.64373038
68MST40.63147217
69CAMK40.62560269
70DAPK30.61044009
71RPS6KA50.58940183
72TRIM280.56398491
73PDGFRA0.56187107
74OXSR10.55320016
75KDR0.51950988
76CSNK1G10.51915055
77WNK10.51165657
78PLK40.50424250
79STK380.50095522
80AKT30.49666316
81CSNK1G30.48663562
82CAMK10.48469891
83PRKACB0.47999684
84ROCK20.47630588
85SGK20.47493801
86CAMK2A0.47144184
87CSNK1G20.47139423
88ADRBK10.45611200
89TGFBR20.45100611
90RPS6KC10.44845264
91RPS6KL10.44845264
92MAPKAPK50.44508338
93PTK2B0.42491114
94EPHB10.41629837
95NLK0.41472730
96SIK10.41224561
97TAOK30.40866077
98CSNK1A1L0.40082037
99PRKACA0.37607558
100EPHA30.37293107
101RPS6KA60.37165771
102AKT20.37098656
103MAP2K70.36338851
104PRKACG0.35599873
105MAP2K40.35565431
106STK110.35432168
107CAMK2G0.35245256
108PDPK10.33845971
109CAMK2B0.33162322
110MKNK10.32053638
111PLK20.30919332
112MAP2K10.30876894
113STK30.30516865
114PDK10.30253993
115STK390.29768723
116PRKCE0.29615952
117ICK0.29557062
118PRKD30.28846237
119TAF10.28483242
120BLK0.28285239
121CAMKK20.28219958
122VRK20.28106286
123PTK60.27244385
124MAP2K60.26487537
125LATS10.24660305
126PRKCH0.24021488
127RPS6KA10.23789417
128MAPK110.23625552
129PRKG10.20938262
130CAMK1D0.19006277
131MAP3K100.18078155
132LATS20.17460117
133MTOR0.17160477
134SGK10.16504033
135JAK10.16384185
136RPS6KA30.15510954
137SGK30.15230796
138MAPK70.14772722
139RET0.14433193
140PRKG20.13425190
141LRRK20.13250416
142NME20.11768773
143CAMK1G0.10196104
144MARK30.09552247
145FER0.09161347
146LIMK10.08991112
147PRKCQ0.07937363
148TAOK10.07907203

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.04468019
2Cardiac muscle contraction_Homo sapiens_hsa042604.35277216
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.31215457
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.81426612
5Dilated cardiomyopathy_Homo sapiens_hsa054143.77887655
6Propanoate metabolism_Homo sapiens_hsa006403.31423413
7Parkinsons disease_Homo sapiens_hsa050123.07859858
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03642880
9Oxidative phosphorylation_Homo sapiens_hsa001902.94275024
10Fatty acid degradation_Homo sapiens_hsa000712.79514344
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.60268388
12Carbon metabolism_Homo sapiens_hsa012002.55899879
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29668497
14Alzheimers disease_Homo sapiens_hsa050102.27740128
15Fatty acid metabolism_Homo sapiens_hsa012122.16490298
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15006579
17Huntingtons disease_Homo sapiens_hsa050161.89157812
18Nitrogen metabolism_Homo sapiens_hsa009101.86752882
19Pyruvate metabolism_Homo sapiens_hsa006201.85721333
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77903712
21Viral myocarditis_Homo sapiens_hsa054161.70785867
22Phototransduction_Homo sapiens_hsa047441.60311007
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51211794
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41689361
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29854778
26Butanoate metabolism_Homo sapiens_hsa006501.27800202
27Systemic lupus erythematosus_Homo sapiens_hsa053221.27646287
28Protein export_Homo sapiens_hsa030601.26526820
29Starch and sucrose metabolism_Homo sapiens_hsa005001.24976642
30Linoleic acid metabolism_Homo sapiens_hsa005911.23414936
31Biosynthesis of amino acids_Homo sapiens_hsa012301.22580225
32Insulin resistance_Homo sapiens_hsa049311.22004757
33Basal transcription factors_Homo sapiens_hsa030221.21716945
34Glucagon signaling pathway_Homo sapiens_hsa049221.21565117
35Fatty acid elongation_Homo sapiens_hsa000621.20877049
36Fanconi anemia pathway_Homo sapiens_hsa034601.20108013
37Homologous recombination_Homo sapiens_hsa034401.19001331
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18807530
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13333208
40PPAR signaling pathway_Homo sapiens_hsa033201.12719792
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.12416639
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.10476746
43Regulation of autophagy_Homo sapiens_hsa041401.08615875
44Insulin signaling pathway_Homo sapiens_hsa049101.08159557
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07266278
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04242870
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03903000
48RNA degradation_Homo sapiens_hsa030181.03424300
49Selenocompound metabolism_Homo sapiens_hsa004501.02853549
50Sulfur metabolism_Homo sapiens_hsa009201.01895839
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99592498
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98835447
53RNA polymerase_Homo sapiens_hsa030200.95997383
54Purine metabolism_Homo sapiens_hsa002300.95392804
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91089292
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88680549
57AMPK signaling pathway_Homo sapiens_hsa041520.86302127
58Alcoholism_Homo sapiens_hsa050340.84955105
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84325906
60Calcium signaling pathway_Homo sapiens_hsa040200.83058627
61Sulfur relay system_Homo sapiens_hsa041220.82933358
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81395326
63Olfactory transduction_Homo sapiens_hsa047400.79364706
64Proteasome_Homo sapiens_hsa030500.79276600
65Oxytocin signaling pathway_Homo sapiens_hsa049210.77521418
66Galactose metabolism_Homo sapiens_hsa000520.74876047
67beta-Alanine metabolism_Homo sapiens_hsa004100.74658820
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74028433
69Tryptophan metabolism_Homo sapiens_hsa003800.73842824
70HIF-1 signaling pathway_Homo sapiens_hsa040660.73682144
71Focal adhesion_Homo sapiens_hsa045100.73010296
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72136329
73Ether lipid metabolism_Homo sapiens_hsa005650.71897598
74Lysine degradation_Homo sapiens_hsa003100.70869078
75One carbon pool by folate_Homo sapiens_hsa006700.69019417
76Arginine biosynthesis_Homo sapiens_hsa002200.66465811
77Fatty acid biosynthesis_Homo sapiens_hsa000610.64288198
78Arginine and proline metabolism_Homo sapiens_hsa003300.63231926
79Tight junction_Homo sapiens_hsa045300.62583978
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.62194321
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61722340
82Taste transduction_Homo sapiens_hsa047420.60918974
83Fructose and mannose metabolism_Homo sapiens_hsa000510.60309619
84Nucleotide excision repair_Homo sapiens_hsa034200.59939262
85Type II diabetes mellitus_Homo sapiens_hsa049300.59581703
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59175317
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.57757584
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55604625
89Circadian rhythm_Homo sapiens_hsa047100.53003319
90Salivary secretion_Homo sapiens_hsa049700.50779084
91Phenylalanine metabolism_Homo sapiens_hsa003600.49908253
92Caffeine metabolism_Homo sapiens_hsa002320.49869651
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47491039
94Peroxisome_Homo sapiens_hsa041460.46805466
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43971628
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42846877
97Renin secretion_Homo sapiens_hsa049240.42547843
98GABAergic synapse_Homo sapiens_hsa047270.42505848
99Morphine addiction_Homo sapiens_hsa050320.41257961
100Nicotine addiction_Homo sapiens_hsa050330.40314447
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40144018
102Adherens junction_Homo sapiens_hsa045200.38044373
103Gastric acid secretion_Homo sapiens_hsa049710.37008665
104ECM-receptor interaction_Homo sapiens_hsa045120.36499457
105cAMP signaling pathway_Homo sapiens_hsa040240.35180338
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31886858
107Pyrimidine metabolism_Homo sapiens_hsa002400.30567496
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.30256210
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29440846
110Chemical carcinogenesis_Homo sapiens_hsa052040.28808812
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28724082
112Insulin secretion_Homo sapiens_hsa049110.27519141
113Amphetamine addiction_Homo sapiens_hsa050310.26887836
114Amoebiasis_Homo sapiens_hsa051460.26677573
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26520589
116Arachidonic acid metabolism_Homo sapiens_hsa005900.25037877
117Metabolic pathways_Homo sapiens_hsa011000.24215053
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.22887765
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21744297
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.18893628
121mTOR signaling pathway_Homo sapiens_hsa041500.18450619
122Pentose phosphate pathway_Homo sapiens_hsa000300.18312170
123Platelet activation_Homo sapiens_hsa046110.17432909
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16727244
125Tyrosine metabolism_Homo sapiens_hsa003500.16623340
126Fat digestion and absorption_Homo sapiens_hsa049750.16131840
127Circadian entrainment_Homo sapiens_hsa047130.15609661
128FoxO signaling pathway_Homo sapiens_hsa040680.14734352
129Proteoglycans in cancer_Homo sapiens_hsa052050.14532073
130Glycerolipid metabolism_Homo sapiens_hsa005610.13933578
131Renal cell carcinoma_Homo sapiens_hsa052110.13720943
132GnRH signaling pathway_Homo sapiens_hsa049120.13212004
133VEGF signaling pathway_Homo sapiens_hsa043700.11285124
134Ovarian steroidogenesis_Homo sapiens_hsa049130.05948050
135Dorso-ventral axis formation_Homo sapiens_hsa043200.04490789
136Pancreatic secretion_Homo sapiens_hsa049720.03029787
137Cholinergic synapse_Homo sapiens_hsa047250.02174672
138Toxoplasmosis_Homo sapiens_hsa051450.01474011
139Gap junction_Homo sapiens_hsa045400.01112108
140MAPK signaling pathway_Homo sapiens_hsa040100.00981740
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.00849245
142ABC transporters_Homo sapiens_hsa02010-0.0503537
143PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0483350
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0424533
145Bile secretion_Homo sapiens_hsa04976-0.0316698
146Small cell lung cancer_Homo sapiens_hsa05222-0.0252431
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0179245

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