FSHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)9.33277931
2estrogen biosynthetic process (GO:0006703)9.33131157
3androgen biosynthetic process (GO:0006702)8.74257149
4somite development (GO:0061053)8.08326735
5regulation of meiosis I (GO:0060631)7.84047852
6sex differentiation (GO:0007548)7.58009477
7piRNA metabolic process (GO:0034587)6.93033487
8positive regulation of T cell differentiation in thymus (GO:0033089)6.91895767
9negative regulation of macrophage differentiation (GO:0045650)6.80950586
10oocyte development (GO:0048599)6.66864920
11male sex determination (GO:0030238)6.46210045
12regulation of female gonad development (GO:2000194)6.41762708
13cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.40596907
14Leydig cell differentiation (GO:0033327)6.39092356
15negative regulation of T cell differentiation in thymus (GO:0033085)6.21442779
16embryonic digestive tract morphogenesis (GO:0048557)6.09777201
17chondrocyte proliferation (GO:0035988)6.01685620
18fusion of sperm to egg plasma membrane (GO:0007342)5.78200494
19anatomical structure regression (GO:0060033)5.68782341
20glomerular basement membrane development (GO:0032836)5.65804477
21negative regulation of alpha-beta T cell differentiation (GO:0046639)5.47540973
22activin receptor signaling pathway (GO:0032924)5.46227195
23ovulation cycle (GO:0042698)5.24852038
24hemoglobin metabolic process (GO:0020027)5.18454931
25positive regulation of gastrulation (GO:2000543)5.12929651
26cellular response to gonadotropin stimulus (GO:0071371)5.06507872
27regulation of cardioblast differentiation (GO:0051890)5.03241299
28synaptonemal complex assembly (GO:0007130)4.89469832
29estrogen metabolic process (GO:0008210)4.83923164
30DNA methylation involved in gamete generation (GO:0043046)4.75801350
31response to follicle-stimulating hormone (GO:0032354)4.75138443
32synaptonemal complex organization (GO:0070193)4.73710729
33smooth muscle tissue development (GO:0048745)4.73389402
34extracellular matrix assembly (GO:0085029)4.69183071
35endoderm formation (GO:0001706)4.54557461
36male genitalia development (GO:0030539)4.54261120
37regulation of mesoderm development (GO:2000380)4.49678248
38positive regulation of reproductive process (GO:2000243)4.49241052
39seminiferous tubule development (GO:0072520)4.47931518
40male meiosis (GO:0007140)4.47542830
41androgen metabolic process (GO:0008209)4.45731059
42gastrulation with mouth forming second (GO:0001702)4.31981276
43positive regulation of meiosis (GO:0045836)4.30980711
44limb bud formation (GO:0060174)4.25373909
45plasma membrane fusion (GO:0045026)4.24675192
46cardiac muscle hypertrophy in response to stress (GO:0014898)4.23540639
47muscle hypertrophy in response to stress (GO:0003299)4.23540639
48cardiac muscle adaptation (GO:0014887)4.23540639
49cellular response to interferon-alpha (GO:0035457)4.17466483
50cellular response to cadmium ion (GO:0071276)4.06391538
51cardiac muscle hypertrophy (GO:0003300)4.04106532
52pancreas development (GO:0031016)4.03195077
53astrocyte development (GO:0014002)4.02781081
54primitive streak formation (GO:0090009)4.00900042
55regulation of transforming growth factor beta2 production (GO:0032909)3.98907023
56positive regulation of meiotic cell cycle (GO:0051446)3.94425402
57maintenance of protein location in nucleus (GO:0051457)3.88527117
58cell migration involved in gastrulation (GO:0042074)3.80064570
59striated muscle hypertrophy (GO:0014897)3.78698385
60SMAD protein signal transduction (GO:0060395)3.74865778
61negative regulation of meiosis (GO:0045835)3.74352807
62ovarian follicle development (GO:0001541)3.68807953
63positive regulation of receptor biosynthetic process (GO:0010870)3.68408567
64fibroblast migration (GO:0010761)3.67106096
65poly(A)+ mRNA export from nucleus (GO:0016973)3.66538286
66atrioventricular valve morphogenesis (GO:0003181)3.66415881
67signal transduction involved in regulation of gene expression (GO:0023019)3.65980587
68response to gonadotropin (GO:0034698)3.54855510
69negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.49563805
70reproductive system development (GO:0061458)3.49539404
71response to misfolded protein (GO:0051788)3.47311384
72apoptotic cell clearance (GO:0043277)3.45279775
73growth hormone secretion (GO:0030252)3.40557141
74leukotriene biosynthetic process (GO:0019370)3.39047889
75positive regulation of catenin import into nucleus (GO:0035413)3.36665044
76* ovulation cycle process (GO:0022602)3.36192663
77gastrulation (GO:0007369)3.35347024
78germ cell migration (GO:0008354)3.34550524
79embryonic pattern specification (GO:0009880)3.29444794
80mating behavior (GO:0007617)3.27872749
81genitalia development (GO:0048806)3.27132015
82embryonic foregut morphogenesis (GO:0048617)3.24745201
83otic vesicle formation (GO:0030916)3.22094254
84progesterone metabolic process (GO:0042448)3.21763294
85replication fork processing (GO:0031297)3.21401830
86epithelial cell-cell adhesion (GO:0090136)3.21390964
87response to leptin (GO:0044321)3.17002966
88cellular response to leptin stimulus (GO:0044320)3.14991039
89positive regulation of heart growth (GO:0060421)3.12514775
90anterior/posterior axis specification, embryo (GO:0008595)3.12344371
91artery development (GO:0060840)3.11366432
92positive regulation of cardiac muscle cell proliferation (GO:0060045)3.10971201
93somite rostral/caudal axis specification (GO:0032525)3.10057885
94response to pheromone (GO:0019236)3.09970562
95Sertoli cell development (GO:0060009)3.09033669
96vagina development (GO:0060068)3.08748605
97muscle hypertrophy (GO:0014896)3.07289248
98protein heterotrimerization (GO:0070208)3.07118398
99cellular response to antibiotic (GO:0071236)3.06934587
100forebrain morphogenesis (GO:0048853)3.05790350
101hormone biosynthetic process (GO:0042446)3.05235947
102atrial septum morphogenesis (GO:0060413)3.04401651
103regulation of mesenchymal cell apoptotic process (GO:2001053)3.03148474
104regulation of endocrine process (GO:0044060)3.01852699
105regulation of activin receptor signaling pathway (GO:0032925)3.01050376
106adrenal gland development (GO:0030325)2.98991469
107negative regulation of interferon-gamma production (GO:0032689)2.97631647
108heart looping (GO:0001947)2.97473736
109regulation of protein polyubiquitination (GO:1902914)2.97381162
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.97197879
111* female gonad development (GO:0008585)2.95854170
112positive regulation of cardiac muscle tissue growth (GO:0055023)2.95796738
113bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94740498
114protein neddylation (GO:0045116)2.91739947
115response to BMP (GO:0071772)2.90955217
116cellular response to BMP stimulus (GO:0071773)2.90955217
117regulation of developmental pigmentation (GO:0048070)2.90805100
118organ formation (GO:0048645)2.90294769
119positive regulation of mesonephros development (GO:0061213)2.89843492
120negative regulation of cytokine biosynthetic process (GO:0042036)2.89520625
121ketone biosynthetic process (GO:0042181)2.89173282
122endocardial cushion development (GO:0003197)2.88581910
123glomerulus development (GO:0032835)2.87560778
124negative regulation of DNA repair (GO:0045738)2.87477792
125receptor guanylyl cyclase signaling pathway (GO:0007168)2.82776498
126negative regulation of erythrocyte differentiation (GO:0045647)2.82344959
127diaphragm development (GO:0060539)2.81354131
128response to vitamin E (GO:0033197)2.81177659
129regulation of interferon-gamma biosynthetic process (GO:0045072)2.79826592
130negative regulation of metanephros development (GO:0072217)2.79612662
131positive regulation of cardiac muscle tissue development (GO:0055025)2.78338295
132glucocorticoid biosynthetic process (GO:0006704)2.77195185
133glial cell proliferation (GO:0014009)2.77137156
134embryonic eye morphogenesis (GO:0048048)2.76782496
135natural killer cell differentiation (GO:0001779)2.76555561
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75693197
137gene silencing by RNA (GO:0031047)2.75689861
138macroautophagy (GO:0016236)2.73824509
139negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.73710429
140anterior/posterior axis specification (GO:0009948)2.73420305
141epoxygenase P450 pathway (GO:0019373)2.73258402
142C21-steroid hormone biosynthetic process (GO:0006700)2.73083314
143embryonic axis specification (GO:0000578)2.72174911
144proline transport (GO:0015824)2.71452546
145male meiosis I (GO:0007141)2.70679380
146mesenchymal to epithelial transition (GO:0060231)2.70224861
147negative regulation of activin receptor signaling pathway (GO:0032926)2.69440088
148striated muscle adaptation (GO:0014888)2.68800730
149embryonic heart tube morphogenesis (GO:0003143)2.68546048
150urogenital system development (GO:0001655)2.68142792
151chromosome organization involved in meiosis (GO:0070192)2.68086591
152cardiac right ventricle morphogenesis (GO:0003215)2.67001565
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66494510
154germ cell development (GO:0007281)2.66258495
155adhesion of symbiont to host (GO:0044406)2.65382568
156endoderm development (GO:0007492)2.63996074
157prostate gland growth (GO:0060736)2.63211692
158cardiac myofibril assembly (GO:0055003)2.63094243
159regulation of T cell differentiation in thymus (GO:0033081)2.62622094
160embryonic camera-type eye morphogenesis (GO:0048596)2.62243102
161meiotic nuclear division (GO:0007126)2.60656055
162centriole replication (GO:0007099)2.59254600
163mitotic G1 DNA damage checkpoint (GO:0031571)2.57613921
164positive regulation of chondrocyte differentiation (GO:0032332)2.57330875
165female genitalia development (GO:0030540)2.52242798
166positive regulation of response to oxidative stress (GO:1902884)2.52036705
167gonadal mesoderm development (GO:0007506)18.3688428
168positive regulation of male gonad development (GO:2000020)11.9253765
169sex determination (GO:0007530)11.4122233
170regulation of male gonad development (GO:2000018)10.4682478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.09070063
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.65385895
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41879044
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.34201355
5ZNF263_19887448_ChIP-Seq_K562_Human3.30112797
6CLOCK_20551151_ChIP-Seq_293T_Human3.25270628
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93845740
8VDR_22108803_ChIP-Seq_LS180_Human2.75404177
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.71418061
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.70878100
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.57883336
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50865513
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.49569573
14GBX2_23144817_ChIP-Seq_PC3_Human2.47675939
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46222582
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.44110305
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43370089
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43370089
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43370089
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.35823577
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.35379212
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.34676311
23EWS_26573619_Chip-Seq_HEK293_Human2.33007252
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26832021
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16643102
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11954731
27* SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.07544128
28* SMAD3_21741376_ChIP-Seq_HESCs_Human2.06116874
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04012747
30P300_19829295_ChIP-Seq_ESCs_Human2.00952065
31* SMAD3_21741376_ChIP-Seq_EPCs_Human1.99034197
32FUS_26573619_Chip-Seq_HEK293_Human1.96663226
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.95906149
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95056306
35TP53_16413492_ChIP-PET_HCT116_Human1.91347249
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88552574
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85227545
38KDM2B_26808549_Chip-Seq_K562_Human1.83269574
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83177874
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.81346711
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.80709215
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79276094
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79213524
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.78648378
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75426959
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74796422
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71968873
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71822809
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68800341
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.68578816
51KDM2B_26808549_Chip-Seq_DND41_Human1.67152464
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.65343123
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65090906
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64355652
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64040393
56TCF7_22412390_ChIP-Seq_EML_Mouse1.63961963
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.63247864
58* SMAD4_21741376_ChIP-Seq_EPCs_Human1.62082463
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61529963
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59140563
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57117880
62TAF15_26573619_Chip-Seq_HEK293_Human1.54944431
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53175418
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.52964513
65CREB1_26743006_Chip-Seq_LNCaP_Human1.52178382
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50482689
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50482689
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48688606
69CBP_20019798_ChIP-Seq_JUKART_Human1.48688606
70* TCF4_22108803_ChIP-Seq_LS180_Human1.48071168
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47747804
72SMAD4_21799915_ChIP-Seq_A2780_Human1.46867066
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45521841
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45474930
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.45464928
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45459962
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40873590
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40156198
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.39275868
80TP53_22127205_ChIP-Seq_IMR90_Human1.38677345
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.38228129
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37971915
83CHD1_26751641_Chip-Seq_LNCaP_Human1.37684864
84NANOG_19829295_ChIP-Seq_ESCs_Human1.37464983
85SOX2_19829295_ChIP-Seq_ESCs_Human1.37464983
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36801461
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36456042
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.35741860
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35635330
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35285703
91* RNF2_27304074_Chip-Seq_NSC_Mouse1.35227662
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35131799
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34882235
94* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33615977
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33615977
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31563011
97TCF4_23295773_ChIP-Seq_U87_Human1.31018263
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30978561
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.30916225
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29594485
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29158888
102* STAT3_23295773_ChIP-Seq_U87_Human1.29127005
103ELK1_19687146_ChIP-ChIP_HELA_Human1.28458773
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27329272
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.27079279
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26584315
107RUNX2_22187159_ChIP-Seq_PCA_Human1.26267220
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26245659
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25900037
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.25419779
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24797203
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.23910900
113ER_23166858_ChIP-Seq_MCF-7_Human1.23886274
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23070136
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21548726
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21013782
117P53_22387025_ChIP-Seq_ESCs_Mouse1.20927368
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20672501
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17911883
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16937530
121RACK7_27058665_Chip-Seq_MCF-7_Human1.16468388
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.16238827
123NCOR1_26117541_ChIP-Seq_K562_Human1.15881960
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.15207567
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14503744
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14167746
127P300_18555785_Chip-Seq_ESCs_Mouse1.13809260
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13400240
129FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13229351
130* CDX2_22108803_ChIP-Seq_LS180_Human1.12628877
131* AR_25329375_ChIP-Seq_VCAP_Human1.12284150
132PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11424594
133EZH2_22144423_ChIP-Seq_EOC_Human1.11229154
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11049046
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09963493
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.09300359
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09254062
138STAT3_18555785_Chip-Seq_ESCs_Mouse1.09164787
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09153767
140SALL1_21062744_ChIP-ChIP_HESCs_Human1.09131923
141FOXA2_19822575_ChIP-Seq_HepG2_Human1.08603585
142EOMES_21245162_ChIP-Seq_HESCs_Human1.08560742
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08322095
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07528014
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07469238
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07073398
147SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06382110
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06211604
149ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06057774
150* ISL1_27105846_Chip-Seq_CPCs_Mouse1.05027573
151SA1_27219007_Chip-Seq_ERYTHROID_Human1.04819627
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04814423
153SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04769477
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04468735
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04449834
156GATA3_24758297_ChIP-Seq_MCF-7_Human1.03635104
157* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03486950
158EZH2_27304074_Chip-Seq_ESCs_Mouse1.01599946
159SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01411117
160SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00723013
161DROSHA_22980978_ChIP-Seq_HELA_Human1.00201394
162BCAT_22108803_ChIP-Seq_LS180_Human0.99499432
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98988244
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98277393
165UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97948666
166SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96767014
167CTCF_27219007_Chip-Seq_Bcells_Human0.96446471
168STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96001106
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.95784154
170TBX20_22328084_ChIP-Seq_HEART_Mouse0.95784154
171ZNF274_21170338_ChIP-Seq_K562_Hela0.94789522
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94444841
173CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93785708
174CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93279981
175ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93116807
176KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92718458
177ESR2_21235772_ChIP-Seq_MCF-7_Human0.91467765
178FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91354748
179PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89810938
180CBX2_27304074_Chip-Seq_ESCs_Mouse0.89364822
181RING1B_27294783_Chip-Seq_ESCs_Mouse0.89344517
182CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87842217
183EP300_21415370_ChIP-Seq_HL-1_Mouse0.87555807
184IGF1R_20145208_ChIP-Seq_DFB_Human0.87235864
185SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87194783
186KLF5_25053715_ChIP-Seq_YYC3_Human0.84930298
187KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83518222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.83834638
2* MP0008995_early_reproductive_senescence5.15610257
3MP0005377_hearing/vestibular/ear_phenot5.03979752
4MP0003878_abnormal_ear_physiology5.03979752
5MP0001661_extended_life_span4.26021776
6MP0003315_abnormal_perineum_morphology4.06808879
7MP0009384_cardiac_valve_regurgitation3.69813159
8MP0003890_abnormal_embryonic-extraembry3.63157634
9* MP0005647_abnormal_sex_gland2.57329273
10* MP0002210_abnormal_sex_determination2.55877653
11MP0009278_abnormal_bone_marrow2.50435687
12MP0003879_abnormal_hair_cell2.34080728
13MP0003045_fibrosis2.33594881
14MP0002102_abnormal_ear_morphology2.28164160
15MP0000462_abnormal_digestive_system2.22666745
16* MP0001145_abnormal_male_reproductive2.21187112
17* MP0001929_abnormal_gametogenesis2.19296063
18MP0003136_yellow_coat_color2.18633182
19MP0001958_emphysema2.18320142
20MP0001919_abnormal_reproductive_system2.17768593
21MP0000639_abnormal_adrenal_gland2.15246002
22MP0001727_abnormal_embryo_implantation2.14914278
23MP0003011_delayed_dark_adaptation2.13004664
24MP0004215_abnormal_myocardial_fiber2.12152608
25MP0004272_abnormal_basement_membrane2.12086135
26MP0003828_pulmonary_edema2.02444489
27MP0005389_reproductive_system_phenotype2.00065627
28MP0005410_abnormal_fertilization1.99884646
29* MP0000653_abnormal_sex_gland1.97406423
30MP0002009_preneoplasia1.90673154
31MP0003123_paternal_imprinting1.88855361
32MP0002127_abnormal_cardiovascular_syste1.88113202
33MP0008004_abnormal_stomach_pH1.86233110
34MP0003937_abnormal_limbs/digits/tail_de1.80978377
35MP0000751_myopathy1.78643513
36MP0005623_abnormal_meninges_morphology1.78198581
37MP0009697_abnormal_copulation1.73114017
38* MP0003786_premature_aging1.71563857
39* MP0003936_abnormal_reproductive_system1.70758281
40* MP0003698_abnormal_male_reproductive1.65380282
41MP0002160_abnormal_reproductive_system1.63765111
42MP0000372_irregular_coat_pigmentation1.57857979
43MP0004147_increased_porphyrin_level1.56230064
44MP0003115_abnormal_respiratory_system1.55508026
45MP0009250_abnormal_appendicular_skeleto1.54822898
46MP0002234_abnormal_pharynx_morphology1.48684364
47MP0002751_abnormal_autonomic_nervous1.42913335
48MP0009379_abnormal_foot_pigmentation1.41303887
49MP0002837_dystrophic_cardiac_calcinosis1.39149197
50MP0003137_abnormal_impulse_conducting1.38310756
51MP0000516_abnormal_urinary_system1.35005316
52MP0005367_renal/urinary_system_phenotyp1.35005316
53MP0008438_abnormal_cutaneous_collagen1.34632655
54MP0004084_abnormal_cardiac_muscle1.34581102
55MP0004133_heterotaxia1.34252153
56MP0001529_abnormal_vocalization1.33867869
57MP0003787_abnormal_imprinting1.28682323
58MP0000537_abnormal_urethra_morphology1.28670783
59MP0003866_abnormal_defecation1.27402420
60MP0003943_abnormal_hepatobiliary_system1.24867923
61MP0002822_catalepsy1.23959651
62MP0001851_eye_inflammation1.23717195
63MP0004145_abnormal_muscle_electrophysio1.21055171
64MP0005187_abnormal_penis_morphology1.19069847
65MP0006138_congestive_heart_failure1.18378197
66MP0004036_abnormal_muscle_relaxation1.18218795
67MP0004085_abnormal_heartbeat1.18113122
68MP0001293_anophthalmia1.17655703
69MP0009780_abnormal_chondrocyte_physiolo1.17224104
70MP0006292_abnormal_olfactory_placode1.17005226
71* MP0001119_abnormal_female_reproductive1.16725834
72MP0005248_abnormal_Harderian_gland1.16357442
73MP0005551_abnormal_eye_electrophysiolog1.13430550
74MP0002736_abnormal_nociception_after1.11560602
75MP0002233_abnormal_nose_morphology1.11396180
76MP0010094_abnormal_chromosome_stability1.11250468
77* MP0002168_other_aberrant_phenotype1.10348013
78MP0000383_abnormal_hair_follicle1.09249632
79MP0002254_reproductive_system_inflammat1.08802303
80MP0008775_abnormal_heart_ventricle1.08379756
81MP0001440_abnormal_grooming_behavior1.08096660
82MP0003300_gastrointestinal_ulcer1.07963784
83MP0010368_abnormal_lymphatic_system1.07746469
84MP0010030_abnormal_orbit_morphology1.07450091
85MP0005171_absent_coat_pigmentation1.07061719
86* MP0002161_abnormal_fertility/fecundity1.04360679
87MP0003221_abnormal_cardiomyocyte_apopto1.04297613
88MP0003718_maternal_effect1.03894366
89MP0005503_abnormal_tendon_morphology1.03812663
90MP0004742_abnormal_vestibular_system1.02122363
91MP0002132_abnormal_respiratory_system1.01678237
92MP0005330_cardiomyopathy1.01469461
93MP0000427_abnormal_hair_cycle1.01333066
94MP0008057_abnormal_DNA_replication1.01074732
95MP0000767_abnormal_smooth_muscle0.96335786
96* MP0003699_abnormal_female_reproductive0.95924791
97MP0003121_genomic_imprinting0.95127467
98MP0003942_abnormal_urinary_system0.94825855
99MP0010678_abnormal_skin_adnexa0.94673246
100MP0005391_vision/eye_phenotype0.94321672
101MP0005076_abnormal_cell_differentiation0.94222152
102MP0002972_abnormal_cardiac_muscle0.92853186
103MP0008872_abnormal_physiological_respon0.92416604
104MP0002088_abnormal_embryonic_growth/wei0.91934915
105MP0003984_embryonic_growth_retardation0.90507365
106MP0002163_abnormal_gland_morphology0.90245952
107MP0002909_abnormal_adrenal_gland0.89937919
108MP0008875_abnormal_xenobiotic_pharmacok0.89437165
109MP0002295_abnormal_pulmonary_circulatio0.89244968
110MP0001340_abnormal_eyelid_morphology0.89242008
111MP0002092_abnormal_eye_morphology0.88555448
112MP0005408_hypopigmentation0.87884157
113MP0005380_embryogenesis_phenotype0.87058322
114MP0001672_abnormal_embryogenesis/_devel0.87058322
115MP0005253_abnormal_eye_physiology0.86689878
116MP0003941_abnormal_skin_development0.85301760
117MP0004233_abnormal_muscle_weight0.83084264
118MP0003567_abnormal_fetal_cardiomyocyte0.81625619
119* MP0005395_other_phenotype0.81231646
120MP0006072_abnormal_retinal_apoptosis0.80821961
121MP0002932_abnormal_joint_morphology0.80627120
122MP0002697_abnormal_eye_size0.80035289
123MP0000470_abnormal_stomach_morphology0.79468824
124* MP0002109_abnormal_limb_morphology0.79163647
125MP0000428_abnormal_craniofacial_morphol0.77955641
126MP0003632_abnormal_nervous_system0.76805394
127MP0003091_abnormal_cell_migration0.76643130
128MP0000049_abnormal_middle_ear0.73084089
129MP0005646_abnormal_pituitary_gland0.71378097
130MP0002111_abnormal_tail_morphology0.70854935
131MP0003119_abnormal_digestive_system0.70704839
132MP0001730_embryonic_growth_arrest0.70691878
133MP0004134_abnormal_chest_morphology0.68556471
134MP0001286_abnormal_eye_development0.67275854
135MP0008058_abnormal_DNA_repair0.67207162
136* MP0002115_abnormal_skeleton_extremities0.66939339
137MP0003385_abnormal_body_wall0.66833273
138MP0001697_abnormal_embryo_size0.65474019
139MP0005394_taste/olfaction_phenotype0.64681600
140MP0005499_abnormal_olfactory_system0.64681600
141MP0002896_abnormal_bone_mineralization0.63631605
142MP0004885_abnormal_endolymph0.63150061
143MP0002282_abnormal_trachea_morphology0.62115398
144MP0004197_abnormal_fetal_growth/weight/0.61913255
145MP0003283_abnormal_digestive_organ0.59923819
146MP0000627_abnormal_mammary_gland0.58681709
147MP0002090_abnormal_vision0.58424741
148MP0001881_abnormal_mammary_gland0.57795994
149MP0005670_abnormal_white_adipose0.57768515
150MP0008961_abnormal_basal_metabolism0.56589268
151MP0000534_abnormal_ureter_morphology0.52893398
152MP0002084_abnormal_developmental_patter0.52220181
153MP0006054_spinal_hemorrhage0.51352498
154MP0000467_abnormal_esophagus_morphology0.50106162
155MP0005397_hematopoietic_system_phenotyp0.48701744
156MP0001545_abnormal_hematopoietic_system0.48701744
157MP0010386_abnormal_urinary_bladder0.48698223
158MP0004883_abnormal_blood_vessel0.48348687
159MP0002166_altered_tumor_susceptibility0.45875589
160MP0005508_abnormal_skeleton_morphology0.45286173
161MP0001784_abnormal_fluid_regulation0.44867333
162MP0003705_abnormal_hypodermis_morpholog0.43971877
163* MP0002128_abnormal_blood_circulation0.43784976
164MP0002139_abnormal_hepatobiliary_system0.43439793

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)9.09485671
2Abnormal sex determination (HP:0012244)9.08986989
3Sex reversal (HP:0012245)9.08986989
4* Gonadal dysgenesis (HP:0000133)8.66559697
5* Gonadotropin excess (HP:0000837)8.32474649
6Male pseudohermaphroditism (HP:0000037)6.85618811
7Testicular neoplasm (HP:0010788)6.83794399
8Azoospermia (HP:0000027)5.56597692
9Abnormality of the proximal phalanges of the hand (HP:0009834)5.27000977
10Short tibia (HP:0005736)5.26070930
11Abnormality of male internal genitalia (HP:0000022)5.11043200
12Aplasia/Hypoplasia of the tibia (HP:0005772)5.10666975
13Infertility (HP:0000789)5.00679813
14Premature ovarian failure (HP:0008209)4.88834926
15Abnormal spermatogenesis (HP:0008669)4.71248617
16Abnormality of the 1st metacarpal (HP:0010009)4.65278282
17Hypoplasia of the uterus (HP:0000013)4.53441209
18Abnormality of the middle phalanges of the toes (HP:0010183)4.24399598
19Germ cell neoplasia (HP:0100728)4.04834363
20Ankle contracture (HP:0006466)3.98453747
21Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.79730703
22Facial diplegia (HP:0001349)3.79717221
23Relative macrocephaly (HP:0004482)3.71058375
24Mesangial abnormality (HP:0001966)3.66199638
25True hermaphroditism (HP:0010459)3.60363189
26Rectal prolapse (HP:0002035)3.56226795
27Hypoplastic left heart (HP:0004383)3.45322511
28Abnormality of the 2nd finger (HP:0004100)3.42601681
29Cupped ribs (HP:0000887)3.38894523
30Aplasia/hypoplasia of the uterus (HP:0008684)3.30307787
31Short humerus (HP:0005792)3.29715185
32Short phalanx of the thumb (HP:0009660)3.28892442
33Short hallux (HP:0010109)3.28584752
3411 pairs of ribs (HP:0000878)3.25787475
35Flared iliac wings (HP:0002869)3.23557397
36Abnormality of the phalanges of the hallux (HP:0010057)3.21117432
37Ankle clonus (HP:0011448)3.20849021
38Aplasia/hypoplasia of the humerus (HP:0006507)3.17378738
39Lymphangioma (HP:0100764)3.14976403
40Aplasia/Hypoplasia of the hallux (HP:0008362)3.12473401
41Hand muscle atrophy (HP:0009130)3.11797469
42Abnormal umbilical cord blood vessels (HP:0011403)3.05766651
43Single umbilical artery (HP:0001195)3.05766651
44Abnormality of the fetal cardiovascular system (HP:0010948)3.05766651
45Menstrual irregularities (HP:0000858)2.99959867
46Metaphyseal cupping (HP:0003021)2.98998911
47Hypoventilation (HP:0002791)2.95450138
48Abnormality of carpal bone ossification (HP:0006257)2.94499525
49Absent phalangeal crease (HP:0006109)2.88097130
50Selective tooth agenesis (HP:0001592)2.87313979
51* Hyperpituitarism (HP:0010514)2.80719012
52Protrusio acetabuli (HP:0003179)2.74086482
53Stridor (HP:0010307)2.70457761
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.68745102
55Tongue fasciculations (HP:0001308)2.66004751
56Preaxial foot polydactyly (HP:0001841)2.62721426
57Symphalangism affecting the phalanges of the hand (HP:0009773)2.61737198
58Bladder diverticulum (HP:0000015)2.59848847
59Distal upper limb amyotrophy (HP:0007149)2.52025769
60Upper limb amyotrophy (HP:0009129)2.52025769
61Abnormal finger flexion creases (HP:0006143)2.51367823
62Hypoplastic heart (HP:0001961)2.46597008
63Abnormal hand bone ossification (HP:0010660)2.43630475
64Muscle fibrillation (HP:0010546)2.39054130
65Hypoplastic pelvis (HP:0008839)2.38106803
66Renal cortical cysts (HP:0000803)2.37948401
67Diaphragmatic weakness (HP:0009113)2.37148670
68Short middle phalanx of finger (HP:0005819)2.36366553
69Abnormal pancreas size (HP:0012094)2.36106356
70Bifid tongue (HP:0010297)2.33823468
71Intestinal atresia (HP:0011100)2.33068758
72Macroorchidism (HP:0000053)2.26295969
73Osteomalacia (HP:0002749)2.26188505
74* Secondary amenorrhea (HP:0000869)2.25716924
75Septo-optic dysplasia (HP:0100842)2.23950247
76Renovascular hypertension (HP:0100817)2.23600094
77Double outlet right ventricle (HP:0001719)2.21937978
78Congenital malformation of the right heart (HP:0011723)2.21937978
79Enlarged penis (HP:0000040)2.20404955
80Ovarian neoplasm (HP:0100615)2.19740796
81Abnormality of femoral epiphyses (HP:0006499)2.15562502
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.15562502
83Short femoral neck (HP:0100864)2.13267819
84Genu varum (HP:0002970)2.12863831
85Pulmonary artery stenosis (HP:0004415)2.09329718
86* Primary amenorrhea (HP:0000786)2.06575673
87Hypoplasia of the ulna (HP:0003022)2.06471054
88Central scotoma (HP:0000603)2.05553812
89Periauricular skin pits (HP:0100277)2.05286131
90Preauricular pit (HP:0004467)2.05286131
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.04838885
92Occipital encephalocele (HP:0002085)2.04579013
93Missing ribs (HP:0000921)2.04265339
94Cupped ear (HP:0000378)2.03677062
95Abnormality of the lower motor neuron (HP:0002366)2.03166604
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.02953770
97Cerebral aneurysm (HP:0004944)1.99940660
98Narrow palate (HP:0000189)1.99211894
99Abnormal ossification of hand bones (HP:0005921)1.98959359
100Oligodactyly (HP:0012165)1.98280088
101Abnormality of the fibula (HP:0002991)1.95400002
102Pancreatic fibrosis (HP:0100732)1.95395595
103Abnormality of the fovea (HP:0000493)1.95022950
104Pancreatic cysts (HP:0001737)1.94322388
105Clonus (HP:0002169)1.94248740
106Abnormality of the vocal cords (HP:0008777)1.93829351
107Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.93514323
108* Polycystic ovaries (HP:0000147)1.92401155
109Bilateral microphthalmos (HP:0007633)1.92278064
110Renal salt wasting (HP:0000127)1.90732686
111Female pseudohermaphroditism (HP:0010458)1.90292065
112Abnormality of the umbilical cord (HP:0010881)1.90143517
113Coxa vara (HP:0002812)1.89389915
114Abnormal lung lobation (HP:0002101)1.87443987
115Inguinal hernia (HP:0000023)1.86565465
116Aplasia involving bones of the upper limbs (HP:0009823)1.86000369
117Aplasia of the phalanges of the hand (HP:0009802)1.86000369
118Aplasia involving bones of the extremities (HP:0009825)1.86000369
119Follicular hyperkeratosis (HP:0007502)1.85397541
120Hypophosphatemic rickets (HP:0004912)1.85006229
121Abnormality of the epiphysis of the femoral head (HP:0010574)1.83154803
122Patent foramen ovale (HP:0001655)1.82783587
123Ovoid vertebral bodies (HP:0003300)1.80562761
124Abnormality of the renal cortex (HP:0011035)1.80413754
125Abnormality of chromosome stability (HP:0003220)1.79483914
126Myopathic facies (HP:0002058)1.79210133
127Hyperacusis (HP:0010780)1.77784094
128Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77571825
129Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.76505960
130Spondylolisthesis (HP:0003302)1.75943992
131Clumsiness (HP:0002312)1.74783298
132Abnormality of the duodenum (HP:0002246)1.74347154
133Hypoglycemic coma (HP:0001325)1.74325065
134Meckel diverticulum (HP:0002245)1.74084395
135Hypoplasia of the iris (HP:0007676)1.74030087
136Broad palm (HP:0001169)1.73816689
137Absent eyebrow (HP:0002223)1.73630266
138Stage 5 chronic kidney disease (HP:0003774)1.73490551
139Abnormal connection of the cardiac segments (HP:0011545)1.72679730
140Abnormal ventriculo-arterial connection (HP:0011563)1.72679730
141Transposition of the great arteries (HP:0001669)1.72679730
142Abnormality of the femoral head (HP:0003368)1.70922974
143Abnormality of the ileum (HP:0001549)1.69832645
144Aplasia/Hypoplasia of the ulna (HP:0006495)1.69753306
145Abnormality of the epiphyses of the hand (HP:0005924)1.68835045
146Abnormality of midbrain morphology (HP:0002418)1.68287427
147Increased variability in muscle fiber diameter (HP:0003557)1.66928696
148Abnormality of the musculature of the hand (HP:0001421)1.65815693
149Aortic aneurysm (HP:0004942)1.65665499
150Abnormal hemoglobin (HP:0011902)1.65294462
151Aortic dissection (HP:0002647)1.61946745
152Gynecomastia (HP:0000771)1.60874737
153Limb-girdle muscle weakness (HP:0003325)1.59139167
154* Pulmonary fibrosis (HP:0002206)1.58693578
155Hypoplastic iliac wings (HP:0002866)1.58410047
156Insomnia (HP:0100785)1.54574477
157Subacute progressive viral hepatitis (HP:0006572)1.54292230
158Thin bony cortex (HP:0002753)1.53702204
159Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.52971455
160* Arachnodactyly (HP:0001166)1.52841829
161Nephritis (HP:0000123)1.52604832
162Humeroradial synostosis (HP:0003041)1.52481189
163Synostosis involving the elbow (HP:0003938)1.52481189
164Abnormality of dentin (HP:0010299)1.50838312
165Striae distensae (HP:0001065)1.49353785
166Vitreoretinal degeneration (HP:0000655)1.48027822
167Renal duplication (HP:0000075)1.46678399
168Neonatal short-limb short stature (HP:0008921)1.46445528
169Pointed chin (HP:0000307)1.46275446
170Type 1 muscle fiber predominance (HP:0003803)1.45967742
171Premature rupture of membranes (HP:0001788)1.42905158
172Abnormality of skeletal muscle fiber size (HP:0012084)1.42426454
173Primary adrenal insufficiency (HP:0008207)1.41409087
174Fibular hypoplasia (HP:0003038)1.40956586
175Multiple enchondromatosis (HP:0005701)1.39634308
176Abnormality of the peritoneum (HP:0002585)1.39316557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO35.63516147
2CDK124.78134539
3TRIB33.49357432
4MAPKAPK33.35265349
5PLK43.30691123
6NUAK13.30361206
7FRK3.23171561
8ACVR1B2.84306173
9TRIM282.72884958
10PBK2.71557745
11TSSK62.59654040
12RIPK12.41889867
13CDK72.40939787
14MST42.38974305
15ICK2.36669249
16PTK62.34929282
17WNK32.32112821
18LATS12.31523694
19PRKD32.26387555
20CDK92.21923118
21BMPR1B2.13199639
22WNK12.12342728
23MAP3K42.10369135
24TNK21.96707237
25BRD41.94450857
26CASK1.84283169
27DAPK21.71175956
28OBSCN1.71142459
29PNCK1.71065026
30EIF2AK31.70185617
31PINK11.68406092
32INSRR1.66317447
33NME11.62768701
34PLK31.60732659
35AKT31.58258581
36DAPK11.57350147
37MYLK1.56406467
38PKN21.51774828
39EEF2K1.48730488
40STK31.46142915
41CSNK1A1L1.42023171
42CDK41.40571981
43PDGFRA1.39485825
44BRSK21.38785731
45TAOK21.36546544
46FLT31.34002034
47STK38L1.32730519
48PTK2B1.31510288
49WNK41.29613368
50EPHB11.27346343
51NEK11.26880389
52FER1.26336180
53MKNK21.22610526
54GRK11.22418120
55ZAK1.19504041
56MAP4K21.13999942
57PRPF4B1.12637415
58PAK21.12462770
59PLK21.11059768
60WEE11.10780828
61TAF11.09715309
62LMTK21.06262123
63LATS21.03198489
64MKNK11.03036561
65MTOR0.99165589
66PRKCE0.99008725
67BCR0.98510488
68TNIK0.88044669
69BMX0.87598983
70MAPK130.82704902
71MAPK120.81005950
72CSNK1G10.80792838
73MAP3K100.80373857
74PRKAA20.78753294
75MELK0.78186086
76ADRBK20.77201741
77STK390.76989221
78STK40.76793441
79EIF2AK20.73829740
80OXSR10.73526384
81ERBB40.73387487
82MAP3K120.72704248
83EPHA40.71938662
84RET0.71860370
85CDK60.71842697
86ERBB30.71641760
87PTK20.70852312
88BUB10.69912239
89MAP3K20.69640693
90LRRK20.69284041
91PLK10.68988340
92DAPK30.68115875
93DMPK0.67239674
94MAP2K20.66655648
95CSNK1G30.66555417
96TTN0.65814097
97PDK40.64760818
98PDK30.64760818
99FGFR20.63581381
100VRK20.62495610
101PRKG20.60701072
102ADRBK10.60587420
103CAMK1G0.60046348
104VRK10.59649780
105CHUK0.59400160
106NEK20.58591282
107PASK0.57169843
108TYK20.55686135
109NTRK30.55148091
110PAK40.55008751
111CDC42BPA0.54888800
112KSR20.54469405
113DYRK1A0.54454362
114SGK2230.54325228
115SGK4940.54325228
116CAMK1D0.52165873
117MAPK10.51650162
118ERBB20.51333478
119PDK20.51332846
120TESK10.51019847
121CSNK1G20.50131728
122SGK20.49566592
123MET0.48691299
124MAP2K70.48227724
125TGFBR10.47634183
126TIE10.47537951
127CDK30.47228985
128MAP3K50.46035605
129EPHB20.45804381
130EGFR0.45425852
131MAPK30.45335984
132ATR0.43327679
133TTK0.43246112
134CHEK20.41887392
135SGK30.41692657
136ATM0.40876574
137FGFR10.40162578
138PRKCH0.39293357
139PRKD20.38564938
140PDGFRB0.37523109
141RPS6KA50.36299386
142MAP2K40.36171515
143PAK30.35052015
144TLK10.34979510
145GSK3B0.34588886
146PRKAA10.33952253
147PAK10.33157261
148BRSK10.32930698
149DYRK1B0.32881824
150ROCK10.32438382
151PIK3CG0.32338313
152CSNK1D0.32204429
153CSNK1E0.31390858
154AKT10.31350299
155PRKACB0.31017455
156CAMK2A0.30037597
157MAPK140.29495352
158AKT20.29350747
159MUSK0.29144600
160STK160.28905283
161CDK10.28121653
162PRKDC0.28055632
163CDC70.27793939
164BRAF0.27700768
165NEK90.26829912
166ERN10.26481218
167SIK10.26423848
168PRKG10.26068629

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ovarian steroidogenesis_Homo sapiens_hsa049134.44994486
2Steroid hormone biosynthesis_Homo sapiens_hsa001404.41082306
3Propanoate metabolism_Homo sapiens_hsa006403.45537724
4Fatty acid biosynthesis_Homo sapiens_hsa000613.18971716
5Hedgehog signaling pathway_Homo sapiens_hsa043403.10528293
6ECM-receptor interaction_Homo sapiens_hsa045123.02476700
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.45815720
8Fatty acid metabolism_Homo sapiens_hsa012122.41790501
9Dorso-ventral axis formation_Homo sapiens_hsa043202.39155334
10TGF-beta signaling pathway_Homo sapiens_hsa043502.36778428
11Non-homologous end-joining_Homo sapiens_hsa034502.32485696
12Aldosterone synthesis and secretion_Homo sapiens_hsa049252.27577042
13Steroid biosynthesis_Homo sapiens_hsa001002.24213980
14Small cell lung cancer_Homo sapiens_hsa052222.13344725
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09647407
16Proteasome_Homo sapiens_hsa030502.08346499
17Amoebiasis_Homo sapiens_hsa051462.05158734
18Homologous recombination_Homo sapiens_hsa034402.05000230
19Butanoate metabolism_Homo sapiens_hsa006502.03447044
20Selenocompound metabolism_Homo sapiens_hsa004502.01589254
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90806739
22Lysine degradation_Homo sapiens_hsa003101.90534991
23Vitamin digestion and absorption_Homo sapiens_hsa049771.84753873
24Fanconi anemia pathway_Homo sapiens_hsa034601.82142538
25Basal cell carcinoma_Homo sapiens_hsa052171.78276074
26Focal adhesion_Homo sapiens_hsa045101.75711657
27Fatty acid elongation_Homo sapiens_hsa000621.71556947
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71158696
29One carbon pool by folate_Homo sapiens_hsa006701.70455024
30Axon guidance_Homo sapiens_hsa043601.61321492
31Protein digestion and absorption_Homo sapiens_hsa049741.53437413
32Renin secretion_Homo sapiens_hsa049241.48175579
33Fatty acid degradation_Homo sapiens_hsa000711.42286688
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40914413
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35300324
36mRNA surveillance pathway_Homo sapiens_hsa030151.34515022
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34203345
38Complement and coagulation cascades_Homo sapiens_hsa046101.34129838
39Protein export_Homo sapiens_hsa030601.34112841
40Caffeine metabolism_Homo sapiens_hsa002321.33177645
41Hippo signaling pathway_Homo sapiens_hsa043901.30986442
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27770137
43PPAR signaling pathway_Homo sapiens_hsa033201.24859653
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22870684
45Viral myocarditis_Homo sapiens_hsa054161.20583223
46Tryptophan metabolism_Homo sapiens_hsa003801.18830778
47RNA degradation_Homo sapiens_hsa030181.18795512
48Mismatch repair_Homo sapiens_hsa034301.17223961
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15560932
50Notch signaling pathway_Homo sapiens_hsa043301.13690209
51Phototransduction_Homo sapiens_hsa047441.11986150
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11573912
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11400377
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10627665
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10255688
56Toxoplasmosis_Homo sapiens_hsa051451.10108103
57* cAMP signaling pathway_Homo sapiens_hsa040241.08001070
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.07457859
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05637940
60Prolactin signaling pathway_Homo sapiens_hsa049171.03397629
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01823727
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.00666666
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00343622
64Peroxisome_Homo sapiens_hsa041460.99921854
65Proteoglycans in cancer_Homo sapiens_hsa052050.98489272
66Pyruvate metabolism_Homo sapiens_hsa006200.97995746
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.96224563
68Mineral absorption_Homo sapiens_hsa049780.95503344
69Wnt signaling pathway_Homo sapiens_hsa043100.93714766
70* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93243183
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89376366
72Insulin resistance_Homo sapiens_hsa049310.89332694
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.88363856
74beta-Alanine metabolism_Homo sapiens_hsa004100.86916529
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83740544
76Estrogen signaling pathway_Homo sapiens_hsa049150.83220283
77Oocyte meiosis_Homo sapiens_hsa041140.83204318
78Basal transcription factors_Homo sapiens_hsa030220.80600008
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78476269
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76899251
81Pathways in cancer_Homo sapiens_hsa052000.75531318
82Nicotine addiction_Homo sapiens_hsa050330.75393041
83Gastric acid secretion_Homo sapiens_hsa049710.74860845
84Tight junction_Homo sapiens_hsa045300.73928990
85Linoleic acid metabolism_Homo sapiens_hsa005910.73427909
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.72664012
87Herpes simplex infection_Homo sapiens_hsa051680.72173195
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.70226069
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69958515
90Oxytocin signaling pathway_Homo sapiens_hsa049210.69945136
91Retinol metabolism_Homo sapiens_hsa008300.68596925
92Base excision repair_Homo sapiens_hsa034100.68071031
93Melanogenesis_Homo sapiens_hsa049160.67469886
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64796619
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64784402
96HTLV-I infection_Homo sapiens_hsa051660.63806343
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61340543
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59499270
99Nucleotide excision repair_Homo sapiens_hsa034200.58252881
100MicroRNAs in cancer_Homo sapiens_hsa052060.57698435
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56914864
102Cell cycle_Homo sapiens_hsa041100.55652357
103Olfactory transduction_Homo sapiens_hsa047400.55647826
104Ether lipid metabolism_Homo sapiens_hsa005650.55413463
105Adherens junction_Homo sapiens_hsa045200.55293693
106Metabolic pathways_Homo sapiens_hsa011000.55070028
107Choline metabolism in cancer_Homo sapiens_hsa052310.54513593
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.54414969
109Purine metabolism_Homo sapiens_hsa002300.54072881
110Cocaine addiction_Homo sapiens_hsa050300.53978206
111mTOR signaling pathway_Homo sapiens_hsa041500.53782384
112ABC transporters_Homo sapiens_hsa020100.53356387
113Prostate cancer_Homo sapiens_hsa052150.52792184
114N-Glycan biosynthesis_Homo sapiens_hsa005100.52422383
115Platelet activation_Homo sapiens_hsa046110.52262319
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51484921
117RNA transport_Homo sapiens_hsa030130.51411036
118Amphetamine addiction_Homo sapiens_hsa050310.50804153
119Arginine and proline metabolism_Homo sapiens_hsa003300.50375470
120Circadian entrainment_Homo sapiens_hsa047130.50340225
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48929973
122Calcium signaling pathway_Homo sapiens_hsa040200.48774117
123Bile secretion_Homo sapiens_hsa049760.48021235
124Serotonergic synapse_Homo sapiens_hsa047260.47395962
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46925240
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46538670
127Carbon metabolism_Homo sapiens_hsa012000.46014896
128Glutathione metabolism_Homo sapiens_hsa004800.45636033
129Influenza A_Homo sapiens_hsa051640.45583764
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45143094
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44694481
132Parkinsons disease_Homo sapiens_hsa050120.43653849
133Glycerolipid metabolism_Homo sapiens_hsa005610.42481789
134Endometrial cancer_Homo sapiens_hsa052130.41030641
135Cardiac muscle contraction_Homo sapiens_hsa042600.40608455
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40287482
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39466287
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.39322985
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39074962
140Salmonella infection_Homo sapiens_hsa051320.38851668
141RNA polymerase_Homo sapiens_hsa030200.38839045
142Gap junction_Homo sapiens_hsa045400.38758515
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38497282
144Thyroid hormone synthesis_Homo sapiens_hsa049180.37839706
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37815684
146Huntingtons disease_Homo sapiens_hsa050160.36686188
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36367964
148Chemical carcinogenesis_Homo sapiens_hsa052040.36286138
149Fat digestion and absorption_Homo sapiens_hsa049750.36114185
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35886603
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35776398
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34495173
153VEGF signaling pathway_Homo sapiens_hsa043700.34349545
154Folate biosynthesis_Homo sapiens_hsa007900.34212877
155Dilated cardiomyopathy_Homo sapiens_hsa054140.34045096
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33820483
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.33803165
158Antigen processing and presentation_Homo sapiens_hsa046120.32940835
159Chronic myeloid leukemia_Homo sapiens_hsa052200.30490228
160Glioma_Homo sapiens_hsa052140.29162927
161Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27737994

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