FSIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.92280044
2piRNA metabolic process (GO:0034587)9.85329651
3male meiosis (GO:0007140)9.37416590
4motile cilium assembly (GO:0044458)9.16974207
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.05898107
6acrosome reaction (GO:0007340)8.96158954
7cilium movement (GO:0003341)8.68746402
8spermatid development (GO:0007286)8.41490110
9synaptonemal complex organization (GO:0070193)8.29980021
10synaptonemal complex assembly (GO:0007130)8.09293234
11single fertilization (GO:0007338)7.80857140
12regulation of cilium movement (GO:0003352)6.67479132
13fertilization (GO:0009566)6.54043644
14DNA methylation involved in gamete generation (GO:0043046)6.46649432
15sperm capacitation (GO:0048240)6.26151975
16chromosome organization involved in meiosis (GO:0070192)5.78395612
17ventricular system development (GO:0021591)5.50583865
18male meiosis I (GO:0007141)5.43646227
19spermatogenesis (GO:0007283)5.38157768
20male gamete generation (GO:0048232)5.36270844
21meiotic nuclear division (GO:0007126)5.17934961
22monoubiquitinated protein deubiquitination (GO:0035520)5.17776708
23microtubule depolymerization (GO:0007019)5.15591749
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.13835938
25cell recognition (GO:0008037)4.98622216
26gamete generation (GO:0007276)4.93920965
27germ cell development (GO:0007281)4.92647111
28negative regulation of inclusion body assembly (GO:0090084)4.84034243
29regulation of pigment cell differentiation (GO:0050932)4.78183218
30positive regulation of developmental pigmentation (GO:0048087)4.74883273
31calcium ion-dependent exocytosis (GO:0017156)4.51359284
32genitalia morphogenesis (GO:0035112)4.50747888
33establishment of protein localization to Golgi (GO:0072600)4.49028448
34meiosis I (GO:0007127)4.35346301
35spermatid nucleus differentiation (GO:0007289)4.33234173
36seminiferous tubule development (GO:0072520)4.21039579
37behavioral response to nicotine (GO:0035095)4.20310220
38organic cation transport (GO:0015695)4.19366255
39protein localization to cilium (GO:0061512)4.18008294
40microtubule severing (GO:0051013)4.09364465
41regulation of inclusion body assembly (GO:0090083)4.01650512
42regulation of microtubule-based movement (GO:0060632)3.93452028
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.92948954
44regulation of translation, ncRNA-mediated (GO:0045974)3.92948954
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.92948954
46meiotic cell cycle (GO:0051321)3.92937564
47intraciliary transport (GO:0042073)3.88041153
48multicellular organismal reproductive process (GO:0048609)3.87204354
49neural tube formation (GO:0001841)3.84524310
50tryptophan catabolic process (GO:0006569)3.83602077
51indole-containing compound catabolic process (GO:0042436)3.83602077
52indolalkylamine catabolic process (GO:0046218)3.83602077
53interkinetic nuclear migration (GO:0022027)3.82885589
54snRNA transcription (GO:0009301)3.75012715
55lactate metabolic process (GO:0006089)3.73894413
56gene silencing by RNA (GO:0031047)3.71140270
57glycerol ether metabolic process (GO:0006662)3.67305828
58indolalkylamine metabolic process (GO:0006586)3.66129059
59protein K11-linked deubiquitination (GO:0035871)3.65588869
60synapsis (GO:0007129)3.58635062
61chaperone-mediated protein complex assembly (GO:0051131)3.57370281
62kynurenine metabolic process (GO:0070189)3.54531840
63regulation of protein polyubiquitination (GO:1902914)3.53089760
64regulation of hippo signaling (GO:0035330)3.49858933
65regulation of establishment of cell polarity (GO:2000114)3.48386111
66negative regulation of protein localization to cell surface (GO:2000009)3.48236119
67left/right pattern formation (GO:0060972)3.42814527
68microtubule-based movement (GO:0007018)3.39279582
69ether metabolic process (GO:0018904)3.38921394
70centriole assembly (GO:0098534)3.35719186
71regulation of centriole replication (GO:0046599)3.34613423
72protein K48-linked deubiquitination (GO:0071108)3.34184958
73centriole replication (GO:0007099)3.28910329
74regulation of sarcomere organization (GO:0060297)3.26426964
75alditol metabolic process (GO:0019400)3.26289511
76detection of light stimulus involved in visual perception (GO:0050908)3.25420307
77detection of light stimulus involved in sensory perception (GO:0050962)3.25420307
78nuclear pore complex assembly (GO:0051292)3.24603039
79GTP biosynthetic process (GO:0006183)3.24596981
80gamma-aminobutyric acid transport (GO:0015812)3.24434564
81lipid translocation (GO:0034204)3.23718915
82phospholipid translocation (GO:0045332)3.23718915
83regulation of meiosis I (GO:0060631)3.23484570
84polyol catabolic process (GO:0046174)3.23386328
85tryptophan metabolic process (GO:0006568)3.22105696
86meiotic cell cycle process (GO:1903046)3.21812789
87negative regulation of sodium ion transport (GO:0010766)3.19743741
88negative regulation of DNA repair (GO:0045738)3.18107345
89axoneme assembly (GO:0035082)3.17691634
90multicellular organismal development (GO:0007275)3.16524860
91protein polyglutamylation (GO:0018095)3.14989351
92negative regulation of organelle assembly (GO:1902116)3.13988046
93cilium organization (GO:0044782)3.13091427
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12926360
95signal peptide processing (GO:0006465)3.08240348
96oxidative demethylation (GO:0070989)3.08086678
97fucose catabolic process (GO:0019317)3.07302364
98L-fucose metabolic process (GO:0042354)3.07302364
99L-fucose catabolic process (GO:0042355)3.07302364
100cellular component assembly involved in morphogenesis (GO:0010927)3.04756801
101reflex (GO:0060004)3.04242785
102nucleoside diphosphate phosphorylation (GO:0006165)3.03860144
103regulation of establishment or maintenance of cell polarity (GO:0032878)3.02778533
104tachykinin receptor signaling pathway (GO:0007217)3.01768526
105glycerol metabolic process (GO:0006071)3.01699339
106regulation of posttranscriptional gene silencing (GO:0060147)3.00621290
107regulation of gene silencing by miRNA (GO:0060964)3.00621290
108regulation of gene silencing by RNA (GO:0060966)3.00621290
109cilium morphogenesis (GO:0060271)3.00134504
110cilium assembly (GO:0042384)2.99805442
111presynaptic membrane assembly (GO:0097105)2.98206600
112photoreceptor cell maintenance (GO:0045494)2.96792795
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96478205
114appendage development (GO:0048736)2.93826272
115limb development (GO:0060173)2.93826272
116flavonoid metabolic process (GO:0009812)2.93258330
117synaptic vesicle docking involved in exocytosis (GO:0016081)2.92560130
118membrane depolarization during action potential (GO:0086010)2.90720248
119UTP biosynthetic process (GO:0006228)2.90654042
120endosome to melanosome transport (GO:0035646)2.89145051
121endosome to pigment granule transport (GO:0043485)2.89145051
122amino-acid betaine transport (GO:0015838)2.88754571
123carnitine transport (GO:0015879)2.88754571
124protein targeting to Golgi (GO:0000042)2.87498447
125carnitine transmembrane transport (GO:1902603)2.87277247
126negative regulation of systemic arterial blood pressure (GO:0003085)2.86660867
127cardiovascular system development (GO:0072358)2.86365325
128histone H3-K4 trimethylation (GO:0080182)2.84090095
129indole-containing compound metabolic process (GO:0042430)2.83781543
130microtubule anchoring (GO:0034453)2.83632608
131serotonin metabolic process (GO:0042428)2.82112306
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79351056
133protein targeting to vacuole (GO:0006623)2.78504823
134protein targeting to lysosome (GO:0006622)2.78504823
135establishment of protein localization to vacuole (GO:0072666)2.78504823
136sulfation (GO:0051923)2.75826840
137protein K63-linked deubiquitination (GO:0070536)2.75193621
138sequestering of actin monomers (GO:0042989)2.74175105
139nucleus localization (GO:0051647)2.73778209
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73668660
141spinal cord motor neuron differentiation (GO:0021522)2.73568707
142microtubule polymerization or depolymerization (GO:0031109)2.72574154
143regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72286077
144neuronal action potential (GO:0019228)2.71932866
145thyroid hormone metabolic process (GO:0042403)2.70958243
146presynaptic membrane organization (GO:0097090)2.70019183
147behavioral response to ethanol (GO:0048149)2.69812013
148pyrimidine nucleobase catabolic process (GO:0006208)2.69079376
149primary amino compound metabolic process (GO:1901160)2.66472138
150central nervous system neuron axonogenesis (GO:0021955)2.65513085
151UTP metabolic process (GO:0046051)2.65440904
152single-organism membrane fusion (GO:0044801)2.64567513
153cellular ketone body metabolic process (GO:0046950)2.63360754
154response to pheromone (GO:0019236)2.60033390
155cellular response to sterol (GO:0036315)2.59919271
156regulation of action potential (GO:0098900)2.59158823
157glycolytic process (GO:0006096)2.58940829
158nonmotile primary cilium assembly (GO:0035058)2.57245841
159negative regulation of mast cell activation (GO:0033004)2.57191873
160membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57187501
161nuclear pore organization (GO:0006999)2.57122890
162central nervous system projection neuron axonogenesis (GO:0021952)2.56544775
163sister chromatid cohesion (GO:0007062)2.55473280
164cytoplasmic mRNA processing body assembly (GO:0033962)2.53535137
165cerebellar Purkinje cell differentiation (GO:0021702)2.52604840
166mitotic sister chromatid cohesion (GO:0007064)2.52540701
167protein localization to synapse (GO:0035418)2.49911392
168protein localization to Golgi apparatus (GO:0034067)2.48804536
169regulation of developmental pigmentation (GO:0048070)2.48723893
170pore complex assembly (GO:0046931)2.46655406
171histone H3-K9 methylation (GO:0051567)2.46308934
172regulation of spindle checkpoint (GO:0090231)2.45497650
173regulation of chromatin binding (GO:0035561)2.45254541
174gene silencing (GO:0016458)2.45198534
175transmission of nerve impulse (GO:0019226)2.44955531
176cellular response to ethanol (GO:0071361)2.42259004
177fusion of sperm to egg plasma membrane (GO:0007342)15.9463257
178cilium or flagellum-dependent cell motility (GO:0001539)15.4847747
179acrosome assembly (GO:0001675)13.3141120
180cell wall macromolecule metabolic process (GO:0044036)12.7943270
181cell wall macromolecule catabolic process (GO:0016998)12.7943270
182multicellular organism reproduction (GO:0032504)12.5459952
183plasma membrane fusion (GO:0045026)12.1831385
184sperm-egg recognition (GO:0035036)11.4131897
185sperm motility (GO:0030317)11.0806824
186axonemal dynein complex assembly (GO:0070286)10.5662074
187cell-cell recognition (GO:0009988)10.2291930
188binding of sperm to zona pellucida (GO:0007339)10.1977718
189reproduction (GO:0000003)10.1862616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.23535032
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.34944930
3EZH2_22144423_ChIP-Seq_EOC_Human4.28107379
4GBX2_23144817_ChIP-Seq_PC3_Human3.55038143
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.48351592
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.14776797
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71903222
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68008125
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59941255
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58235775
11IGF1R_20145208_ChIP-Seq_DFB_Human2.44853516
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.34898972
13ZNF274_21170338_ChIP-Seq_K562_Hela2.33320262
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.12217341
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08189804
16RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse2.07970297
17P300_19829295_ChIP-Seq_ESCs_Human2.07948467
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.02077579
19FUS_26573619_Chip-Seq_HEK293_Human2.01941038
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6333227
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.99351766
22EWS_26573619_Chip-Seq_HEK293_Human1.99253083
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97704861
24STAT3_23295773_ChIP-Seq_U87_Human1.97037112
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96781898
26SMAD4_21799915_ChIP-Seq_A2780_Human1.96382883
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95240542
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89963549
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88410699
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.84525774
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.83057661
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.81146108
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80661305
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75096096
35AR_21572438_ChIP-Seq_LNCaP_Human1.71413161
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69981059
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69538422
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67698802
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67291554
40KDM2B_26808549_Chip-Seq_REH_Human1.65340955
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.63754665
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.62766693
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.58535075
44TP53_16413492_ChIP-PET_HCT116_Human1.58192816
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57510881
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.56401811
47AR_25329375_ChIP-Seq_VCAP_Human1.56300674
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55474860
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54808362
50STAT1_17558387_ChIP-Seq_HELA_Human1.53778581
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.51888934
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.51627406
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47834923
54DROSHA_22980978_ChIP-Seq_HELA_Human1.46609130
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.45986079
56RNF2_27304074_Chip-Seq_NSC_Mouse1.45610011
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42737060
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.42100612
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41901151
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41415644
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.41389689
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.40292742
63P53_22387025_ChIP-Seq_ESCs_Mouse1.38740245
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37377983
65RUNX2_22187159_ChIP-Seq_PCA_Human1.37287112
66P300_18555785_Chip-Seq_ESCs_Mouse1.37103010
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.36552190
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36390686
69CBP_20019798_ChIP-Seq_JUKART_Human1.36390686
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36005612
71AHR_22903824_ChIP-Seq_MCF-7_Human1.34963243
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.34388562
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.32993976
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.32872093
75TCF4_22108803_ChIP-Seq_LS180_Human1.32544097
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32363675
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30730210
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30266075
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30228417
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.28075886
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26969286
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26700241
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.26252947
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.26199558
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.24888894
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24449554
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23603353
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22420662
89VDR_22108803_ChIP-Seq_LS180_Human1.22297706
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20223183
91OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20172680
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18847088
93TAF15_26573619_Chip-Seq_HEK293_Human1.18585059
94GATA3_21867929_ChIP-Seq_CD8_Mouse1.18341964
95RXR_22108803_ChIP-Seq_LS180_Human1.17394745
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16792500
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.16707187
98LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15915305
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15434710
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.14414204
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.13922670
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.13895202
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.10488152
104IRF1_19129219_ChIP-ChIP_H3396_Human1.09707526
105FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09534035
106SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09529809
107REST_21632747_ChIP-Seq_MESCs_Mouse1.09449371
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08952554
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08671170
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08508572
111PU1_27457419_Chip-Seq_LIVER_Mouse1.08157188
112JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08020755
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06705917
114AR_19668381_ChIP-Seq_PC3_Human1.05752306
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.05455426
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05172904
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.04206166
118SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03739975
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03187016
120GF1_26923725_Chip-Seq_HPCs_Mouse1.03116333
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.02518544
122SOX2_19829295_ChIP-Seq_ESCs_Human1.02402945
123NANOG_19829295_ChIP-Seq_ESCs_Human1.02402945
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01846965
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01846965
126EZH2_27304074_Chip-Seq_ESCs_Mouse1.01747816
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01571344
128ER_23166858_ChIP-Seq_MCF-7_Human1.01074614
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.01044745
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00903896
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00903896
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00647554
133TP53_18474530_ChIP-ChIP_U2OS_Human0.99794338
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99655534
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99266974
136SOX9_26525672_Chip-Seq_HEART_Mouse0.97808164
137BCAT_22108803_ChIP-Seq_LS180_Human0.97069417
138TCF4_23295773_ChIP-Seq_U87_Human0.95924892
139GF1B_26923725_Chip-Seq_HPCs_Mouse0.95357013
140RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93902267
141P53_21459846_ChIP-Seq_SAOS-2_Human0.92823213
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91963805
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89845812
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89526738
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.88232458
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87195410
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85153132
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85003565
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84966633
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84353196
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83441036
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82989964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.11563024
2MP0003698_abnormal_male_reproductive5.97276556
3MP0001929_abnormal_gametogenesis5.58156924
4MP0002210_abnormal_sex_determination3.97324081
5MP0002653_abnormal_ependyma_morphology3.67217991
6MP0001145_abnormal_male_reproductive3.33061571
7MP0002161_abnormal_fertility/fecundity3.18926599
8MP0003195_calcinosis3.05514981
9MP0008057_abnormal_DNA_replication2.95221431
10MP0000653_abnormal_sex_gland2.92539014
11MP0005623_abnormal_meninges_morphology2.74128858
12MP0004043_abnormal_pH_regulation2.47500661
13MP0003787_abnormal_imprinting2.42671896
14MP0003890_abnormal_embryonic-extraembry2.15850068
15MP0001968_abnormal_touch/_nociception2.06726584
16MP0005410_abnormal_fertilization14.5576107
17MP0004145_abnormal_muscle_electrophysio1.98476856
18MP0001501_abnormal_sleep_pattern1.93083663
19MP0006276_abnormal_autonomic_nervous1.87282765
20MP0003880_abnormal_central_pattern1.83939456
21MP0009745_abnormal_behavioral_response1.83639686
22MP0004142_abnormal_muscle_tone1.82589620
23MP0001486_abnormal_startle_reflex1.80184507
24MP0009046_muscle_twitch1.77988578
25MP0010386_abnormal_urinary_bladder1.77402646
26MP0002735_abnormal_chemical_nociception1.76819245
27MP0002837_dystrophic_cardiac_calcinosis1.76370889
28MP0002160_abnormal_reproductive_system1.74701125
29MP0005646_abnormal_pituitary_gland1.73254162
30MP0002272_abnormal_nervous_system1.63669465
31MP0008961_abnormal_basal_metabolism1.56834653
32MP0008058_abnormal_DNA_repair1.56126833
33MP0000631_abnormal_neuroendocrine_gland1.55719726
34MP0000383_abnormal_hair_follicle1.54933229
35MP0005386_behavior/neurological_phenoty1.52207953
36MP0004924_abnormal_behavior1.52207953
37MP0005645_abnormal_hypothalamus_physiol1.51824909
38MP0003635_abnormal_synaptic_transmissio1.49709941
39MP0002557_abnormal_social/conspecific_i1.49384029
40MP0002282_abnormal_trachea_morphology1.48978085
41MP0002572_abnormal_emotion/affect_behav1.47220315
42MP0005647_abnormal_sex_gland1.45839882
43MP0002064_seizures1.45289089
44MP0001485_abnormal_pinna_reflex1.41997511
45MP0002067_abnormal_sensory_capabilities1.36647361
46MP0003136_yellow_coat_color1.35565540
47MP0001970_abnormal_pain_threshold1.32651428
48MP0010094_abnormal_chromosome_stability1.32624578
49MP0002063_abnormal_learning/memory/cond1.32526620
50MP0002822_catalepsy1.30893697
51MP0005670_abnormal_white_adipose1.27760106
52MP0002638_abnormal_pupillary_reflex1.25457884
53MP0002733_abnormal_thermal_nociception1.23729145
54MP0003121_genomic_imprinting1.21790108
55MP0002734_abnormal_mechanical_nocicepti1.21625778
56MP0004130_abnormal_muscle_cell1.18663251
57MP0006292_abnormal_olfactory_placode1.18334205
58MP0002184_abnormal_innervation1.17193983
59MP0003786_premature_aging1.17041328
60MP0008872_abnormal_physiological_respon1.16547783
61MP0003937_abnormal_limbs/digits/tail_de1.16096780
62MP0005423_abnormal_somatic_nervous1.14583652
63MP0004215_abnormal_myocardial_fiber1.14064684
64MP0008007_abnormal_cellular_replicative1.12141524
65MP0001765_abnormal_ion_homeostasis1.09178214
66MP0002938_white_spotting1.08385858
67MP0005174_abnormal_tail_pigmentation1.08263246
68MP0002168_other_aberrant_phenotype1.07797144
69MP0000955_abnormal_spinal_cord1.07771622
70MP0004233_abnormal_muscle_weight1.07401263
71MP0001986_abnormal_taste_sensitivity1.04914156
72MP0002882_abnormal_neuron_morphology1.03867555
73MP0008995_early_reproductive_senescence1.03393241
74MP0004134_abnormal_chest_morphology1.03143229
75MP0002876_abnormal_thyroid_physiology1.02429926
76MP0001984_abnormal_olfaction0.99398146
77MP0003119_abnormal_digestive_system0.99195078
78MP0002752_abnormal_somatic_nervous0.99094999
79MP0004270_analgesia0.96443523
80MP0005187_abnormal_penis_morphology0.95727401
81MP0002751_abnormal_autonomic_nervous0.94936067
82MP0005266_abnormal_metabolism0.93329460
83MP0005389_reproductive_system_phenotype0.93129752
84MP0000372_irregular_coat_pigmentation0.91778960
85MP0003011_delayed_dark_adaptation0.89305914
86MP0000538_abnormal_urinary_bladder0.87701568
87MP0008775_abnormal_heart_ventricle0.83887232
88MP0004085_abnormal_heartbeat0.83752884
89MP0003646_muscle_fatigue0.83532445
90MP0004147_increased_porphyrin_level0.83253390
91MP0004885_abnormal_endolymph0.82173653
92MP0004742_abnormal_vestibular_system0.82034824
93MP0001440_abnormal_grooming_behavior0.81681571
94MP0003137_abnormal_impulse_conducting0.81630867
95MP0000230_abnormal_systemic_arterial0.80665549
96MP0004859_abnormal_synaptic_plasticity0.77772186
97MP0001188_hyperpigmentation0.77283651
98MP0010307_abnormal_tumor_latency0.76957572
99MP0000427_abnormal_hair_cycle0.73827653
100MP0002102_abnormal_ear_morphology0.73433248
101MP0001963_abnormal_hearing_physiology0.72390044
102MP0000569_abnormal_digit_pigmentation0.71485657
103MP0005448_abnormal_energy_balance0.71095579
104MP0004019_abnormal_vitamin_homeostasis0.64671770
105MP0003950_abnormal_plasma_membrane0.64430288
106MP0002928_abnormal_bile_duct0.63552115
107MP0004808_abnormal_hematopoietic_stem0.60995887
108MP0005551_abnormal_eye_electrophysiolog0.58073891
109MP0000358_abnormal_cell_content/0.57088285
110MP0001119_abnormal_female_reproductive0.55298384
111MP0002234_abnormal_pharynx_morphology0.54354613
112MP0003699_abnormal_female_reproductive0.54081895
113MP0002139_abnormal_hepatobiliary_system0.52809216
114MP0005636_abnormal_mineral_homeostasis0.52741470
115MP0005253_abnormal_eye_physiology0.48353100
116MP0004036_abnormal_muscle_relaxation0.47954785
117MP0000647_abnormal_sebaceous_gland0.47671737
118MP0001545_abnormal_hematopoietic_system0.46633266
119MP0005397_hematopoietic_system_phenotyp0.46633266
120MP0001324_abnormal_eye_pigmentation0.42023057
121MP0003633_abnormal_nervous_system0.41684004
122MP0006072_abnormal_retinal_apoptosis0.38302070
123MP0002971_abnormal_brown_adipose0.35799897
124MP0005391_vision/eye_phenotype0.33167586
125MP0003111_abnormal_nucleus_morphology0.31325583
126MP0003878_abnormal_ear_physiology0.30856444
127MP0005377_hearing/vestibular/ear_phenot0.30856444
128MP0002269_muscular_atrophy0.29569807
129MP0001730_embryonic_growth_arrest0.28756033
130MP0003631_nervous_system_phenotype0.28675868
131MP0001293_anophthalmia0.27885125
132MP0005666_abnormal_adipose_tissue0.27162024
133MP0004084_abnormal_cardiac_muscle0.26844997
134MP0003077_abnormal_cell_cycle0.26478398
135MP0001727_abnormal_embryo_implantation0.25578900
136MP0005365_abnormal_bile_salt0.25423073
137MP0000313_abnormal_cell_death0.25032046
138MP0006138_congestive_heart_failure0.23874131
139MP0003329_amyloid_beta_deposits0.23170681
140MP0003115_abnormal_respiratory_system0.22794023
141MP0002152_abnormal_brain_morphology0.22033094
142MP0000432_abnormal_head_morphology0.21605888
143MP0009115_abnormal_fat_cell0.21388886
144MP0001851_eye_inflammation0.21345017
145MP0001764_abnormal_homeostasis0.21146402
146MP0009278_abnormal_bone_marrow0.20843072
147MP0002133_abnormal_respiratory_system0.20594544
148MP0005388_respiratory_system_phenotype0.20594544
149MP0003861_abnormal_nervous_system0.19997488
150MP0006036_abnormal_mitochondrial_physio0.19815090
151MP0002084_abnormal_developmental_patter0.19410122
152MP0004811_abnormal_neuron_physiology0.19143125
153MP0002970_abnormal_white_adipose0.18644269
154MP0005076_abnormal_cell_differentiation0.17865033
155MP0003045_fibrosis0.17798669
156MP0008875_abnormal_xenobiotic_pharmacok0.17355590
157MP0002233_abnormal_nose_morphology0.17234464
158MP0000778_abnormal_nervous_system0.16064857
159MP0002229_neurodegeneration0.15990498
160MP0005195_abnormal_posterior_eye0.15838221
161MP0004133_heterotaxia0.15754770
162MP0001919_abnormal_reproductive_system0.15644709
163MP0009697_abnormal_copulation0.14850851
164MP0000751_myopathy0.14664086
165MP0000604_amyloidosis0.13220745
166MP0001661_extended_life_span0.13093785
167MP0002092_abnormal_eye_morphology0.12070147
168MP0003634_abnormal_glial_cell0.11675799
169MP0002736_abnormal_nociception_after0.11230044
170MP0005319_abnormal_enzyme/_coenzyme0.11124467
171MP0003252_abnormal_bile_duct0.10763492

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.81086528
2Abnormal respiratory motile cilium morphology (HP:0005938)9.00656744
3Abnormal respiratory epithelium morphology (HP:0012253)9.00656744
4Abnormal ciliary motility (HP:0012262)8.44305384
5Rhinitis (HP:0012384)7.96582427
6Chronic bronchitis (HP:0004469)7.56680400
7Nasal polyposis (HP:0100582)6.27665874
8Infertility (HP:0000789)5.61222583
9Genetic anticipation (HP:0003743)5.33665910
10Abnormality of the nasal mucosa (HP:0000433)5.16537447
11Hyperventilation (HP:0002883)4.83736758
12Bronchiectasis (HP:0002110)4.50448103
13Bronchitis (HP:0012387)4.44035338
14Pancreatic cysts (HP:0001737)4.41692438
15Progressive cerebellar ataxia (HP:0002073)4.23128144
16Recurrent sinusitis (HP:0011108)4.06602128
17Nephronophthisis (HP:0000090)4.00994338
18Protruding tongue (HP:0010808)3.93103030
19Abnormality of the lower motor neuron (HP:0002366)3.61090877
20Aplasia/Hypoplasia of the tibia (HP:0005772)3.35651845
21Recurrent otitis media (HP:0000403)3.21229289
22Abnormality of the renal medulla (HP:0100957)3.11277476
23Medial flaring of the eyebrow (HP:0010747)3.02977266
24Broad-based gait (HP:0002136)2.94017924
25Fibular hypoplasia (HP:0003038)2.92310643
26Tubulointerstitial nephritis (HP:0001970)2.91011141
27Febrile seizures (HP:0002373)2.86274799
28Male infertility (HP:0003251)2.82480409
29Congenital stationary night blindness (HP:0007642)2.80603506
30Clumsiness (HP:0002312)2.78841179
31Absent speech (HP:0001344)2.75483706
32Amyotrophic lateral sclerosis (HP:0007354)2.75062377
33Fair hair (HP:0002286)2.69584481
34Abnormal spermatogenesis (HP:0008669)2.67161674
35Gonadotropin excess (HP:0000837)2.64117237
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58985260
37Abnormality of midbrain morphology (HP:0002418)2.58346539
38Molar tooth sign on MRI (HP:0002419)2.58346539
39Patellar aplasia (HP:0006443)2.54583393
40Drooling (HP:0002307)2.54386455
41Attenuation of retinal blood vessels (HP:0007843)2.45265701
42Cerebellar dysplasia (HP:0007033)2.43068412
43Focal seizures (HP:0007359)2.38031704
44Recurrent bronchitis (HP:0002837)2.35605297
45Type II lissencephaly (HP:0007260)2.33107062
46Renal cortical cysts (HP:0000803)2.31496397
47Aplasia/Hypoplasia of the patella (HP:0006498)2.30847010
48Excessive salivation (HP:0003781)2.29068391
49Abnormality of the ischium (HP:0003174)2.24998793
50Hypoplastic ischia (HP:0003175)2.23897133
51Tubulointerstitial abnormality (HP:0001969)2.22645827
52Dialeptic seizures (HP:0011146)2.21528938
53Short foot (HP:0001773)2.21048604
54Lissencephaly (HP:0001339)2.20788675
5511 pairs of ribs (HP:0000878)2.20245345
56Azoospermia (HP:0000027)2.19975286
57Inability to walk (HP:0002540)2.19849783
58Volvulus (HP:0002580)2.17635922
59Tubular atrophy (HP:0000092)2.17068073
60Hypoplastic labia majora (HP:0000059)2.16329422
61Widely spaced teeth (HP:0000687)2.15500136
62Bony spicule pigmentary retinopathy (HP:0007737)2.15277402
63Sclerocornea (HP:0000647)2.12979522
64Upper motor neuron abnormality (HP:0002127)2.12977314
65Gait imbalance (HP:0002141)2.12878086
66Anencephaly (HP:0002323)2.12016410
67Congenital primary aphakia (HP:0007707)2.11977109
68Abolished electroretinogram (ERG) (HP:0000550)2.10083530
69Preaxial foot polydactyly (HP:0001841)2.08776785
70Preaxial hand polydactyly (HP:0001177)2.06202639
71Chronic sinusitis (HP:0011109)2.05821716
72Postaxial foot polydactyly (HP:0001830)2.04551468
73Decreased circulating renin level (HP:0003351)2.01230180
74Generalized hypopigmentation of hair (HP:0011358)2.01130752
75Abnormality of the labia majora (HP:0012881)2.00003719
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0207801
77Absent/shortened dynein arms (HP:0200106)13.1291175
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.1291175
79Impaired proprioception (HP:0010831)1.99324390
80Intestinal atresia (HP:0011100)1.98264713
81Urinary bladder sphincter dysfunction (HP:0002839)1.97930294
82Truncal obesity (HP:0001956)1.95446990
83Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92983843
84Central scotoma (HP:0000603)1.92189642
85Tented upper lip vermilion (HP:0010804)1.91002089
86Furrowed tongue (HP:0000221)1.89958801
87Absence seizures (HP:0002121)1.89662415
88Aplasia/Hypoplasia of the fibula (HP:0006492)1.88542718
89Focal motor seizures (HP:0011153)1.87996837
90Microglossia (HP:0000171)1.87574126
91Abnormality of the anterior horn cell (HP:0006802)1.86704555
92Degeneration of anterior horn cells (HP:0002398)1.86704555
93Abnormality of the dental root (HP:0006486)1.85170898
94Taurodontia (HP:0000679)1.85170898
95Abnormality of permanent molar morphology (HP:0011071)1.85170898
96Small hand (HP:0200055)1.84796868
97Stage 5 chronic kidney disease (HP:0003774)1.84467353
98Cupped ear (HP:0000378)1.84378103
99Dysmetric saccades (HP:0000641)1.83454104
100Breast carcinoma (HP:0003002)1.83092925
101Abnormality of the renal cortex (HP:0011035)1.83013449
102Absent frontal sinuses (HP:0002688)1.81849399
103Nephrogenic diabetes insipidus (HP:0009806)1.81498254
104Highly arched eyebrow (HP:0002553)1.81229141
105Congenital hepatic fibrosis (HP:0002612)1.81100592
106Absent radius (HP:0003974)1.81016265
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.80912507
108Congenital sensorineural hearing impairment (HP:0008527)1.79921939
109Progressive inability to walk (HP:0002505)1.79467793
110Oligodactyly (hands) (HP:0001180)1.78974142
111Supernumerary spleens (HP:0009799)1.77945147
112Male pseudohermaphroditism (HP:0000037)1.77000655
113Absent forearm bone (HP:0003953)1.76959431
114Aplasia involving forearm bones (HP:0009822)1.76959431
115Atonic seizures (HP:0010819)1.76801618
116Abnormality of the pubic bones (HP:0003172)1.76668174
117Increased corneal curvature (HP:0100692)1.76560040
118Keratoconus (HP:0000563)1.76560040
119Astigmatism (HP:0000483)1.76373492
120Abnormality of molar morphology (HP:0011070)1.74797367
121Abnormality of molar (HP:0011077)1.74797367
122Selective tooth agenesis (HP:0001592)1.73135454
123Macroglossia (HP:0000158)1.72268482
124Dandy-Walker malformation (HP:0001305)1.71306915
125Thyroid-stimulating hormone excess (HP:0002925)1.71040584
126Epileptic encephalopathy (HP:0200134)1.70004261
127Broad foot (HP:0001769)1.69947329
128Large eyes (HP:0001090)1.69136265
129Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69112017
130Abnormality of the dental pulp (HP:0006479)1.68640641
131Impaired smooth pursuit (HP:0007772)1.68363283
132Oculomotor apraxia (HP:0000657)1.67461560
133Facial cleft (HP:0002006)1.66414559
134Short ribs (HP:0000773)1.65970214
135Postaxial hand polydactyly (HP:0001162)1.65395040
136J-shaped sella turcica (HP:0002680)1.64645179
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.63318160
138Pancreatic fibrosis (HP:0100732)1.62854715
139Abnormality of dentin (HP:0010299)1.62499757
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61558968
141Poor coordination (HP:0002370)1.59560121
142Tubulointerstitial fibrosis (HP:0005576)1.57590212
143Renal dysplasia (HP:0000110)1.57318077
144Genital tract atresia (HP:0001827)1.54427719
145Median cleft lip (HP:0000161)1.52397376
146Vaginal atresia (HP:0000148)1.50912669
147Abnormality of ocular smooth pursuit (HP:0000617)1.50043527
148Impulsivity (HP:0100710)1.49780863
149Cystic liver disease (HP:0006706)1.49121453
150Conjunctival telangiectasia (HP:0000524)1.48780786
151Abnormality of renal excretion (HP:0011036)1.42604814
152Abnormal drinking behavior (HP:0030082)1.41236409
153Polydipsia (HP:0001959)1.41236409
154Vascular calcification (HP:0004934)1.40521747
155Tongue fasciculations (HP:0001308)1.40041455
156Hypoplasia of dental enamel (HP:0006297)1.39781392
157Aplasia/Hypoplasia of the lens (HP:0008063)1.35237116
158True hermaphroditism (HP:0010459)1.31939960
159Abnormality of saccadic eye movements (HP:0000570)1.28396576
160Muscle fibrillation (HP:0010546)1.28147349
161Cardiovascular calcification (HP:0011915)1.28069222
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.27222630
163Chronic hepatic failure (HP:0100626)1.26723983
164Gaze-evoked nystagmus (HP:0000640)1.26701739
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.26037093
166Absent epiphyses (HP:0010577)1.26037093
167Short thorax (HP:0010306)1.25618345
168Heterotopia (HP:0002282)1.23145686
169Limb ataxia (HP:0002070)1.22595047
170Missing ribs (HP:0000921)1.21061425
171Pachygyria (HP:0001302)1.20457834
172Abnormal finger flexion creases (HP:0006143)1.19612770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.27279132
2PDK26.65051364
3ACVR1B3.35293032
4CASK3.08875926
5TESK12.19090947
6PTK2B2.11289794
7WNK42.09110007
8STK392.08744441
9AKT32.07616227
10PNCK2.03639692
11PDK310.2038207
12PDK410.2038207
13MAPK131.93277095
14ADRBK21.84936234
15PRKD31.83751028
16INSRR1.73719146
17MKNK21.71175851
18ICK1.61945899
19MAP4K21.53592746
20GRK11.53232765
21TNIK1.52867375
22TAOK31.49211072
23NTRK31.48381542
24OXSR11.44349146
25NEK21.39386786
26NUAK11.32290413
27CAMK1D1.13883609
28ADRBK11.12738281
29SGK21.12268815
30ZAK1.09124334
31PAK31.04494979
32BRD41.02315212
33PIK3CA0.97040132
34LATS10.95600704
35EPHA40.93147180
36LMTK20.92245177
37WNK10.90584442
38SIK20.89300473
39OBSCN0.88790622
40PDK10.88063378
41TYRO30.87940618
42FGFR20.86933088
43CAMKK20.86218453
44TGFBR10.84178861
45DAPK20.81754914
46SGK2230.81263575
47SGK4940.81263575
48PRKCE0.81255574
49BCR0.80105311
50PASK0.79366426
51CDC70.78343122
52MAP3K70.77985556
53STK30.75832730
54CCNB10.73464447
55STK380.72849262
56WEE10.70392143
57PRKAA20.70192246
58EPHA30.70031992
59PLK40.69507516
60NLK0.68363558
61MKNK10.67907588
62PIK3CG0.66300431
63IRAK10.65695071
64TRPM70.64490746
65CSNK1A1L0.62960825
66TEC0.61983778
67CAMK40.59923815
68TLK10.58828564
69MAP2K40.57448414
70CAMK10.57445613
71MAPK150.55767035
72CHUK0.54400022
73TTK0.54255529
74ERBB20.53172796
75CDK120.52197957
76CHEK20.51926365
77GRK70.51891090
78FER0.51738799
79ATR0.50434656
80TXK0.50084524
81CHEK10.49830968
82DYRK30.49604504
83TRIM280.48998792
84SGK10.45888392
85CDK190.45871441
86DYRK1B0.45424222
87MELK0.43606534
88SGK30.43389226
89CSNK1G20.42078865
90CAMK1G0.41578268
91MAP2K60.40035166
92STK38L0.39167936
93DYRK1A0.38855121
94ERBB30.38679192
95PRKCH0.37921872
96FLT30.36863681
97TESK20.36748558
98CDK30.36568579
99DYRK20.36184805
100ATM0.34685234
101PINK10.33997157
102CSNK1G10.33739291
103CDK50.28891382
104WNK30.27974763
105BRSK20.27277297
106PLK10.26874387
107MAP3K40.23896260
108MAP2K70.22034218
109NEK60.21673769
110PDPK10.18890909
111CAMKK10.17653275
112MTOR0.17008949
113RIPK10.16619730
114PRKAA10.16538072
115RPS6KB10.16437951
116PRKCG0.14647215
117PKN10.14517507
118PAK10.14216435
119NTRK20.14212144
120PRKG10.13896744
121CSNK1D0.13072496
122MARK30.12951354
123PAK20.12518174
124IRAK20.11826393
125PRKACG0.11363114
126EEF2K0.07695209
127PRKDC0.07375325
128MAPKAPK50.07012019
129CDK10.06977331
130PDGFRB0.06488437
131CSNK2A20.06387871
132MUSK0.06292535
133PRKG20.06204322
134PRKACB0.06047687
135CSNK2A10.05948562
136BMPR1B0.05301172
137CDK20.04642485
138MAPK80.04403181
139ZAP700.04143974
140MAPK100.03884190
141EGFR0.03801465
142PRKCQ0.03769665
143YES10.03675726
144CDK150.02840496
145GSK3B0.02633075
146BRAF0.02181402
147MARK20.02019880
148RIPK40.01996131
149MINK10.01981330
150RPS6KA30.01754847
151STK100.01549477
152TTN0.01079262
153BRSK10.01049383
154MAP3K100.00967244
155PRKCB0.00899037
156CDK180.00715309
157INSR0.00142095
158GSK3A-0.0186873
159MARK1-0.0174855
160PTK6-0.0170043
161STK11-0.0133521
162PRKCA-0.0128708
163CDK14-0.0119248
164CAMK2A-0.0075047
165CDK11A-0.0074182
166PRKACA-0.0020330

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.14349805
2Pyruvate metabolism_Homo sapiens_hsa006204.77760571
3Propanoate metabolism_Homo sapiens_hsa006404.10987731
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.02700369
5Pentose phosphate pathway_Homo sapiens_hsa000303.34142663
6Nicotine addiction_Homo sapiens_hsa050333.25569285
7Glucagon signaling pathway_Homo sapiens_hsa049222.91516696
8Basal transcription factors_Homo sapiens_hsa030222.80195727
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.69423385
10Selenocompound metabolism_Homo sapiens_hsa004502.57862284
11Fanconi anemia pathway_Homo sapiens_hsa034602.46140259
12Phototransduction_Homo sapiens_hsa047442.45434864
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.40028341
14Fatty acid biosynthesis_Homo sapiens_hsa000612.39803288
15Butanoate metabolism_Homo sapiens_hsa006502.24405098
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16145217
17Oocyte meiosis_Homo sapiens_hsa041142.13154518
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01553028
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94710281
20Morphine addiction_Homo sapiens_hsa050321.92969784
21Dorso-ventral axis formation_Homo sapiens_hsa043201.90893875
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.86161687
23Huntingtons disease_Homo sapiens_hsa050161.86141970
24Glycerolipid metabolism_Homo sapiens_hsa005611.84216559
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79267571
26Nitrogen metabolism_Homo sapiens_hsa009101.74009680
27GABAergic synapse_Homo sapiens_hsa047271.62274770
28Carbon metabolism_Homo sapiens_hsa012001.62128923
29Tryptophan metabolism_Homo sapiens_hsa003801.61963693
30PPAR signaling pathway_Homo sapiens_hsa033201.61789530
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59309498
32Linoleic acid metabolism_Homo sapiens_hsa005911.52640536
33Serotonergic synapse_Homo sapiens_hsa047261.50826030
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50643265
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50364408
36Lysine degradation_Homo sapiens_hsa003101.47144989
37Renin secretion_Homo sapiens_hsa049241.44907626
38Amphetamine addiction_Homo sapiens_hsa050311.43947181
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42194278
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.35139339
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29375820
42Biosynthesis of amino acids_Homo sapiens_hsa012301.28683060
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26700869
44Cholinergic synapse_Homo sapiens_hsa047251.23421561
45Dopaminergic synapse_Homo sapiens_hsa047281.22425466
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22166061
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20768358
48Long-term depression_Homo sapiens_hsa047301.19561729
49Circadian rhythm_Homo sapiens_hsa047101.18599048
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18380501
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.17180476
52Ovarian steroidogenesis_Homo sapiens_hsa049131.10447750
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09640140
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08401459
55Cardiac muscle contraction_Homo sapiens_hsa042601.07063405
56RNA transport_Homo sapiens_hsa030131.02548905
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.01336383
58Oxytocin signaling pathway_Homo sapiens_hsa049210.99829765
59mRNA surveillance pathway_Homo sapiens_hsa030150.97659834
60Histidine metabolism_Homo sapiens_hsa003400.97112763
61Purine metabolism_Homo sapiens_hsa002300.94364402
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91912336
63Type II diabetes mellitus_Homo sapiens_hsa049300.90818675
64Antigen processing and presentation_Homo sapiens_hsa046120.87101487
65Fructose and mannose metabolism_Homo sapiens_hsa000510.86542778
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84451312
67Axon guidance_Homo sapiens_hsa043600.82926583
68Cocaine addiction_Homo sapiens_hsa050300.82775598
69Caffeine metabolism_Homo sapiens_hsa002320.82266657
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82189149
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82120384
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81852011
73Long-term potentiation_Homo sapiens_hsa047200.81579570
74ABC transporters_Homo sapiens_hsa020100.79841366
75Mineral absorption_Homo sapiens_hsa049780.79798470
76Fatty acid metabolism_Homo sapiens_hsa012120.76333289
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76281235
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.76171924
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72237832
80Fatty acid degradation_Homo sapiens_hsa000710.72041290
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70893884
82Regulation of autophagy_Homo sapiens_hsa041400.70854582
83N-Glycan biosynthesis_Homo sapiens_hsa005100.69592044
84Renin-angiotensin system_Homo sapiens_hsa046140.69507042
85beta-Alanine metabolism_Homo sapiens_hsa004100.69255948
86Hedgehog signaling pathway_Homo sapiens_hsa043400.68261342
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68039016
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67819585
89Collecting duct acid secretion_Homo sapiens_hsa049660.67315048
90Calcium signaling pathway_Homo sapiens_hsa040200.65903961
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63798085
92Fat digestion and absorption_Homo sapiens_hsa049750.63437027
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63077121
94Chemical carcinogenesis_Homo sapiens_hsa052040.62399934
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61024059
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60291363
97Ether lipid metabolism_Homo sapiens_hsa005650.59515662
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59390376
99Inositol phosphate metabolism_Homo sapiens_hsa005620.59302954
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58429987
101Estrogen signaling pathway_Homo sapiens_hsa049150.56804558
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.56717991
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55614790
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55478590
105Glutathione metabolism_Homo sapiens_hsa004800.54322395
106TGF-beta signaling pathway_Homo sapiens_hsa043500.54143646
107Ras signaling pathway_Homo sapiens_hsa040140.52979943
108Hippo signaling pathway_Homo sapiens_hsa043900.52765391
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51584426
110Peroxisome_Homo sapiens_hsa041460.50609752
111FoxO signaling pathway_Homo sapiens_hsa040680.50389608
112Homologous recombination_Homo sapiens_hsa034400.50066831
113Basal cell carcinoma_Homo sapiens_hsa052170.47303355
114MAPK signaling pathway_Homo sapiens_hsa040100.47088002
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.45843098
116Dilated cardiomyopathy_Homo sapiens_hsa054140.45670987
117Choline metabolism in cancer_Homo sapiens_hsa052310.45520582
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44525022
119Sphingolipid metabolism_Homo sapiens_hsa006000.43937125
120Non-homologous end-joining_Homo sapiens_hsa034500.43406095
121Melanoma_Homo sapiens_hsa052180.41984455
122Bile secretion_Homo sapiens_hsa049760.40945412
123Metabolic pathways_Homo sapiens_hsa011000.40757644
124Systemic lupus erythematosus_Homo sapiens_hsa053220.40402331
125VEGF signaling pathway_Homo sapiens_hsa043700.40345600
126Synaptic vesicle cycle_Homo sapiens_hsa047210.40189210
127Insulin secretion_Homo sapiens_hsa049110.39179286
128Taste transduction_Homo sapiens_hsa047420.38860828
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.38528511
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38522565
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37064532
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36099413
133Cell cycle_Homo sapiens_hsa041100.35895696
134Thyroid hormone synthesis_Homo sapiens_hsa049180.34243479
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33356693
136AMPK signaling pathway_Homo sapiens_hsa041520.31659144
137Circadian entrainment_Homo sapiens_hsa047130.29679596
138Sulfur metabolism_Homo sapiens_hsa009200.27044767
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25679495
140Protein digestion and absorption_Homo sapiens_hsa049740.24931727
141Retinol metabolism_Homo sapiens_hsa008300.24844096
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24674091
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23883303
144Olfactory transduction_Homo sapiens_hsa047400.22977735
145Legionellosis_Homo sapiens_hsa051340.22671431
146Endocytosis_Homo sapiens_hsa041440.21338577
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.20998201
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19560044
149B cell receptor signaling pathway_Homo sapiens_hsa046620.19246366
150cAMP signaling pathway_Homo sapiens_hsa040240.18096509
151Complement and coagulation cascades_Homo sapiens_hsa046100.17696209
152Gastric acid secretion_Homo sapiens_hsa049710.17233602
153Viral carcinogenesis_Homo sapiens_hsa052030.17032650
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15879619
155Glutamatergic synapse_Homo sapiens_hsa047240.15815855
156Salivary secretion_Homo sapiens_hsa049700.14618412
157Wnt signaling pathway_Homo sapiens_hsa043100.13121468
158RNA degradation_Homo sapiens_hsa030180.12227305
159Pancreatic secretion_Homo sapiens_hsa049720.12067574
160Arachidonic acid metabolism_Homo sapiens_hsa005900.09058608

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