FSTL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of G0 to G1 transition (GO:0070316)5.20039140
2desmosome organization (GO:0002934)5.12638041
3wound healing, spreading of epidermal cells (GO:0035313)5.05801590
4skin morphogenesis (GO:0043589)4.71794574
5wound healing, spreading of cells (GO:0044319)4.27370193
6collagen fibril organization (GO:0030199)4.24273131
7chondrocyte proliferation (GO:0035988)4.23415682
8peptidyl-proline hydroxylation (GO:0019511)4.21770993
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.18964125
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.85758714
11regulation of water loss via skin (GO:0033561)3.83957628
12epithelial cell-cell adhesion (GO:0090136)3.82099775
13regulation of tight junction assembly (GO:2000810)3.81438104
14focal adhesion assembly (GO:0048041)3.79764900
15cell-substrate adherens junction assembly (GO:0007045)3.79764900
16hemidesmosome assembly (GO:0031581)3.75631073
17establishment of skin barrier (GO:0061436)3.65810443
18protein hydroxylation (GO:0018126)3.64471438
19endodermal cell differentiation (GO:0035987)3.63747300
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.63516489
21adherens junction assembly (GO:0034333)3.63253235
22protein heterotrimerization (GO:0070208)3.56972725
23regulation of integrin-mediated signaling pathway (GO:2001044)3.53179953
24cell adhesion mediated by integrin (GO:0033627)3.50571154
25protein retention in ER lumen (GO:0006621)3.48917216
26protein localization to endosome (GO:0036010)3.44690861
27endothelial cell morphogenesis (GO:0001886)3.44398580
28interferon-gamma secretion (GO:0072643)3.43387638
29folic acid transport (GO:0015884)3.43069783
30sequestering of extracellular ligand from receptor (GO:0035581)3.39705306
31purine nucleobase biosynthetic process (GO:0009113)3.35051202
32ribosome assembly (GO:0042255)3.32806858
33regulation of transforming growth factor beta1 production (GO:0032908)3.31546240
34lung-associated mesenchyme development (GO:0060484)3.31279619
35regulation of plasminogen activation (GO:0010755)3.26032508
36positive regulation of endothelial cell apoptotic process (GO:2000353)3.22134098
37negative regulation of chondrocyte differentiation (GO:0032331)3.20806933
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.15996119
39cellular response to interferon-alpha (GO:0035457)3.15799840
40protein carboxylation (GO:0018214)3.13530302
41peptidyl-glutamic acid carboxylation (GO:0017187)3.13530302
42vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.11025118
43barbed-end actin filament capping (GO:0051016)3.09393667
44plasma membrane repair (GO:0001778)3.08389319
45Golgi transport vesicle coating (GO:0048200)3.07756008
46COPI coating of Golgi vesicle (GO:0048205)3.07756008
47bone trabecula formation (GO:0060346)3.07753036
48basement membrane organization (GO:0071711)3.05920244
49formation of translation preinitiation complex (GO:0001731)3.05423103
50regulation of apoptotic process involved in morphogenesis (GO:1902337)3.03475654
51negative regulation of fatty acid transport (GO:2000192)3.03130261
52low-density lipoprotein particle clearance (GO:0034383)3.02906873
53cell-substrate junction assembly (GO:0007044)2.99724175
54urea cycle (GO:0000050)2.99563982
55ventricular cardiac muscle cell development (GO:0055015)2.98730498
56maturation of SSU-rRNA (GO:0030490)2.97355768
57trophectodermal cell differentiation (GO:0001829)2.96793272
58regulation of cardioblast differentiation (GO:0051890)2.96437315
59nucleobase biosynthetic process (GO:0046112)2.95310763
60blastocyst development (GO:0001824)2.94286702
61bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93640164
62stress fiber assembly (GO:0043149)2.91693749
63positive regulation of odontogenesis (GO:0042482)2.91002630
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89037513
65glomerular basement membrane development (GO:0032836)2.88909329
66fibril organization (GO:0097435)2.88631998
67positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.84995308
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84498546
69hippo signaling (GO:0035329)2.83839509
70type B pancreatic cell proliferation (GO:0044342)2.83472042
71cellular response to vitamin (GO:0071295)2.82867242
72regulation of transforming growth factor beta2 production (GO:0032909)2.81214292
73positive regulation of osteoblast proliferation (GO:0033690)2.80300857
74surfactant homeostasis (GO:0043129)2.78202265
75mesodermal cell differentiation (GO:0048333)2.77849787
76atrioventricular valve morphogenesis (GO:0003181)2.76459389
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.76190187
78labyrinthine layer development (GO:0060711)2.76034318
79nucleotide-sugar biosynthetic process (GO:0009226)2.75404574
80protein targeting to plasma membrane (GO:0072661)2.74955508
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74543145
82regulation of early endosome to late endosome transport (GO:2000641)2.74274342
83peptide cross-linking (GO:0018149)2.72918843
84planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72071658
85UV protection (GO:0009650)2.72058616
86regulation of anoikis (GO:2000209)2.71849787
87urea metabolic process (GO:0019627)2.71078586
88kidney mesenchyme development (GO:0072074)2.70570974
89membrane raft organization (GO:0031579)2.70196829
90cellular response to arsenic-containing substance (GO:0071243)2.70065285
91branching involved in salivary gland morphogenesis (GO:0060445)2.68157573
92folic acid metabolic process (GO:0046655)2.67619245
93renal filtration (GO:0097205)2.66905049
94cellular response to vitamin D (GO:0071305)2.66027709
95adhesion of symbiont to host (GO:0044406)2.65847381
96positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.64947420
97regulation of hippo signaling (GO:0035330)2.64520514
98polarized epithelial cell differentiation (GO:0030859)2.64157986
99extracellular fibril organization (GO:0043206)2.64091577
100hypotonic response (GO:0006971)2.64013486
101branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63901851
102collagen metabolic process (GO:0032963)2.62846575
103positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62681140
104extracellular matrix assembly (GO:0085029)2.62222410
105substrate adhesion-dependent cell spreading (GO:0034446)2.61776994
106extracellular matrix organization (GO:0030198)2.60902452
107substrate-dependent cell migration (GO:0006929)2.59940650
108extracellular structure organization (GO:0043062)2.59784971
109protein maturation by protein folding (GO:0022417)2.59667269
110glomerular visceral epithelial cell development (GO:0072015)2.59325938
111establishment of apical/basal cell polarity (GO:0035089)2.58609404
112regulation of spindle organization (GO:0090224)2.58106478
113pinocytosis (GO:0006907)2.57468674
114trophoblast giant cell differentiation (GO:0060707)2.56906957
115negative regulation of fibrinolysis (GO:0051918)2.56263744
116extracellular matrix disassembly (GO:0022617)2.55280027
117negative regulation of cartilage development (GO:0061037)2.53819776
118positive regulation of astrocyte differentiation (GO:0048711)2.53531039
119cell migration involved in heart development (GO:0060973)2.53283963
120actin filament bundle assembly (GO:0051017)2.52670901
121actin filament bundle organization (GO:0061572)2.52670901
122midgut development (GO:0007494)2.52563612
123collagen catabolic process (GO:0030574)2.52430559
124cell differentiation involved in embryonic placenta development (GO:0060706)2.51765630
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51554761
126membrane budding (GO:0006900)2.50669012
1274-hydroxyproline metabolic process (GO:0019471)2.49911374
128hyaluronan catabolic process (GO:0030214)2.49717257
129actin filament depolymerization (GO:0030042)2.49467603
130multicellular organismal water homeostasis (GO:0050891)2.49087411
131blood vessel endothelial cell migration (GO:0043534)2.48672738
132positive regulation of cartilage development (GO:0061036)2.48496174
133apoptotic cell clearance (GO:0043277)2.47366039
134membrane protein ectodomain proteolysis (GO:0006509)2.47347780
135endocardial cushion development (GO:0003197)2.46970745
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45939116
137negative regulation of smooth muscle cell migration (GO:0014912)2.45381112
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.45190724
139vascular endothelial growth factor signaling pathway (GO:0038084)2.44238197
140cartilage morphogenesis (GO:0060536)2.43562873
141response to laminar fluid shear stress (GO:0034616)2.43386846
142positive regulation of collagen biosynthetic process (GO:0032967)2.42839635
143labyrinthine layer blood vessel development (GO:0060716)2.42502201
144multicellular organismal macromolecule metabolic process (GO:0044259)2.41769097
145cellular response to nutrient (GO:0031670)2.40945227
146positive regulation of epithelial to mesenchymal transition (GO:0010718)2.39895671
147regulation of collagen biosynthetic process (GO:0032965)2.39593419
148proteasome assembly (GO:0043248)2.39555066
149keratinocyte development (GO:0003334)2.39168718
150negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.37431649
151multicellular organismal catabolic process (GO:0044243)2.36519124
152regulation of collagen metabolic process (GO:0010712)2.35630100
153endothelial cell proliferation (GO:0001935)2.32934649
154regulation of SMAD protein import into nucleus (GO:0060390)2.32822923
155regulation of mitotic spindle organization (GO:0060236)2.32546825
156positive regulation of collagen metabolic process (GO:0010714)2.31205356
157multicellular organismal metabolic process (GO:0044236)2.31050331
158muscle cell migration (GO:0014812)2.29391529
159mesenchyme development (GO:0060485)2.26932032
160platelet aggregation (GO:0070527)2.26551816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.37013643
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.19962031
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01432578
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36206118
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01989487
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.54614420
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.52284340
8CLOCK_20551151_ChIP-Seq_293T_Human2.41345394
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38838202
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28794882
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26390235
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.21456492
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09173479
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.09091774
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06222591
16ATF3_27146783_Chip-Seq_COLON_Human2.05703094
17ZNF263_19887448_ChIP-Seq_K562_Human2.04665128
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00738164
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98190469
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.97674716
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.95611783
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94869822
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94405272
24ELK1_22589737_ChIP-Seq_MCF10A_Human1.91260546
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.87236361
26HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.86453319
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.84272358
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80640298
29* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76431290
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76431290
31AR_21909140_ChIP-Seq_LNCAP_Human1.75894629
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.71594870
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69095455
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.68423285
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66872591
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65774239
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64376139
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63857300
39* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63028988
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61712607
41RACK7_27058665_Chip-Seq_MCF-7_Human1.60967104
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60679138
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60475570
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58725942
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56683463
46* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.55942359
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51770072
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49872300
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47507786
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47284820
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46671086
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.45388770
53DCP1A_22483619_ChIP-Seq_HELA_Human1.44042221
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41739849
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41734251
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41584323
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41504661
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39951359
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38633049
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.37264106
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37139159
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36397041
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.36278525
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35890902
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33489346
66XRN2_22483619_ChIP-Seq_HELA_Human1.32302856
67VDR_21846776_ChIP-Seq_THP-1_Human1.30647387
68CJUN_26792858_Chip-Seq_BT549_Human1.30432379
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27534997
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27477327
71* KDM2B_26808549_Chip-Seq_K562_Human1.26732125
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24301553
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.22819048
74BRD4_25478319_ChIP-Seq_HGPS_Human1.22515337
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.22178576
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21811144
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21721500
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21055198
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.20289073
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.20289073
81* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19564340
82TP53_22127205_ChIP-Seq_IMR90_Human1.18877147
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18571223
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18117422
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17744178
86* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17030229
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12727474
88* KDM2B_26808549_Chip-Seq_DND41_Human1.11871357
89GABP_19822575_ChIP-Seq_HepG2_Human1.11574368
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11410366
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08645202
92SMC4_20622854_ChIP-Seq_HELA_Human1.07922852
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07622453
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07579662
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.05742545
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05112041
97* ERG_21242973_ChIP-ChIP_JURKAT_Human1.03631513
98SOX2_20726797_ChIP-Seq_SW620_Human1.03595439
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03103697
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02870375
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02697890
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01381980
103TFEB_21752829_ChIP-Seq_HELA_Human1.01228158
104SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00837920
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00521391
106TP53_23651856_ChIP-Seq_MEFs_Mouse1.00166939
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99582273
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98626820
109* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98505365
110CHD1_26751641_Chip-Seq_LNCaP_Human0.98264771
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98224619
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97987018
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.97542741
114* TCF7_22412390_ChIP-Seq_EML_Mouse0.96370153
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95825263
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.95764626
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94594483
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94460593
119GATA3_24758297_ChIP-Seq_MCF-7_Human0.93681453
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91988246
121P68_20966046_ChIP-Seq_HELA_Human0.91399557
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.91293406
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91019179
124* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90605676
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90560455
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90546025
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90515808
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89684008
129TTF2_22483619_ChIP-Seq_HELA_Human0.89226605
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88508367
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88069320
132* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87477722
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87249381
134GATA4_25053715_ChIP-Seq_YYC3_Human0.87220448
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86869511
136* CREB1_26743006_Chip-Seq_LNCaP_Human0.85464790
137NCOR1_26117541_ChIP-Seq_K562_Human0.85308494
138* TP63_22573176_ChIP-Seq_HFKS_Human0.85255921
139CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84220200
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.83694132
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83465052
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82277503
143LXR_22292898_ChIP-Seq_THP-1_Human0.81833157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.55145562
2MP0005275_abnormal_skin_tensile4.60973605
3MP0003705_abnormal_hypodermis_morpholog4.19537939
4MP0003566_abnormal_cell_adhesion3.21935048
5MP0005503_abnormal_tendon_morphology3.18791082
6MP0004272_abnormal_basement_membrane3.00793476
7MP0003279_aneurysm2.88557541
8MP0005623_abnormal_meninges_morphology2.71092488
9MP0006054_spinal_hemorrhage2.60310730
10MP0001958_emphysema2.58435538
11MP0003941_abnormal_skin_development2.56703243
12MP0010352_gastrointestinal_tract_polyps2.40238806
13MP0002060_abnormal_skin_morphology2.39968170
14MP0005023_abnormal_wound_healing2.28230002
15MP0002796_impaired_skin_barrier2.24285391
16MP0001542_abnormal_bone_strength2.08825768
17MP0009384_cardiac_valve_regurgitation2.00087720
18MP0000579_abnormal_nail_morphology1.95798437
19MP0001849_ear_inflammation1.92659724
20* MP0000003_abnormal_adipose_tissue1.84599655
21MP0003693_abnormal_embryo_hatching1.82357972
22MP0002295_abnormal_pulmonary_circulatio1.78448579
23MP0000750_abnormal_muscle_regeneration1.77533605
24MP0005508_abnormal_skeleton_morphology1.69562522
25MP0004084_abnormal_cardiac_muscle1.68100149
26MP0005257_abnormal_intraocular_pressure1.65595784
27MP0010030_abnormal_orbit_morphology1.60011334
28MP0009840_abnormal_foam_cell1.58841532
29MP0001243_abnormal_dermal_layer1.58763672
30MP0001348_abnormal_lacrimal_gland1.58742075
31MP0003091_abnormal_cell_migration1.54990228
32MP0005501_abnormal_skin_physiology1.53194651
33MP0005409_darkened_coat_color1.51544094
34MP0004957_abnormal_blastocyst_morpholog1.41203255
35MP0004858_abnormal_nervous_system1.38723298
36MP0002877_abnormal_melanocyte_morpholog1.31819489
37MP0010234_abnormal_vibrissa_follicle1.30337849
38* MP0005375_adipose_tissue_phenotype1.28867142
39MP0003123_paternal_imprinting1.27605290
40MP0010368_abnormal_lymphatic_system1.25739043
41MP0000467_abnormal_esophagus_morphology1.25371428
42MP0005058_abnormal_lysosome_morphology1.23984167
43MP0003191_abnormal_cellular_cholesterol1.23515413
44MP0000733_abnormal_muscle_development1.18552338
45MP0000647_abnormal_sebaceous_gland1.16874559
46MP0001216_abnormal_epidermal_layer1.16150063
47MP0005360_urolithiasis1.15953885
48MP0000759_abnormal_skeletal_muscle1.11136040
49MP0008260_abnormal_autophagy1.10019554
50MP0000858_altered_metastatic_potential1.09947401
51MP0003453_abnormal_keratinocyte_physiol1.07739344
52MP0003567_abnormal_fetal_cardiomyocyte1.07358780
53MP0010771_integument_phenotype1.07213727
54MP0003950_abnormal_plasma_membrane1.04111771
55MP0003221_abnormal_cardiomyocyte_apopto1.00601018
56MP0000383_abnormal_hair_follicle1.00588424
57MP0009780_abnormal_chondrocyte_physiolo1.00238880
58MP0005451_abnormal_body_composition1.00109506
59MP0000767_abnormal_smooth_muscle0.98922430
60MP0005595_abnormal_vascular_smooth0.98467491
61MP0005666_abnormal_adipose_tissue0.95512457
62MP0005330_cardiomyopathy0.95286906
63MP0001915_intracranial_hemorrhage0.95122616
64MP0004185_abnormal_adipocyte_glucose0.93269956
65* MP0000013_abnormal_adipose_tissue0.93143510
66MP0003786_premature_aging0.92820242
67MP0004947_skin_inflammation0.91932107
68MP0005390_skeleton_phenotype0.91871758
69MP0005197_abnormal_uvea_morphology0.91604456
70MP0000377_abnormal_hair_follicle0.89868720
71MP0006138_congestive_heart_failure0.89739193
72MP0005165_increased_susceptibility_to0.88780176
73MP0003111_abnormal_nucleus_morphology0.88692938
74MP0001756_abnormal_urination0.88570159
75MP0008932_abnormal_embryonic_tissue0.88136420
76MP0000537_abnormal_urethra_morphology0.87888120
77MP0009931_abnormal_skin_appearance0.87011190
78MP0000762_abnormal_tongue_morphology0.86939627
79MP0003878_abnormal_ear_physiology0.85579766
80MP0005377_hearing/vestibular/ear_phenot0.85579766
81MP0005083_abnormal_biliary_tract0.85476414
82MP0002896_abnormal_bone_mineralization0.85327697
83MP0003984_embryonic_growth_retardation0.84404554
84MP0002108_abnormal_muscle_morphology0.83928823
85MP0001661_extended_life_span0.82725730
86MP0010678_abnormal_skin_adnexa0.82532899
87MP0000428_abnormal_craniofacial_morphol0.82282373
88MP0001730_embryonic_growth_arrest0.82267622
89MP0002086_abnormal_extraembryonic_tissu0.82075489
90MP0002088_abnormal_embryonic_growth/wei0.81960637
91MP0005670_abnormal_white_adipose0.81743650
92MP0008007_abnormal_cellular_replicative0.81096430
93MP0009250_abnormal_appendicular_skeleto0.80955038
94MP0000747_muscle_weakness0.80466556
95MP0000749_muscle_degeneration0.80139743
96MP0000678_abnormal_parathyroid_gland0.79585248
97MP0000627_abnormal_mammary_gland0.79149815
98MP0005380_embryogenesis_phenotype0.77910960
99MP0001672_abnormal_embryogenesis/_devel0.77910960
100MP0002089_abnormal_postnatal_growth/wei0.77897831
101MP0001727_abnormal_embryo_implantation0.77018180
102MP0004087_abnormal_muscle_fiber0.76724144
103MP0003718_maternal_effect0.76491660
104MP0004197_abnormal_fetal_growth/weight/0.76426476
105MP0001299_abnormal_eye_distance/0.75686089
106MP0009053_abnormal_anal_canal0.74988332
107MP0001879_abnormal_lymphatic_vessel0.74755275
108MP0005076_abnormal_cell_differentiation0.74137372
109MP0010630_abnormal_cardiac_muscle0.74074825
110MP0002128_abnormal_blood_circulation0.73471928
111MP0005621_abnormal_cell_physiology0.72878777
112MP0003448_altered_tumor_morphology0.72360155
113MP0003942_abnormal_urinary_system0.72340846
114MP0009333_abnormal_splenocyte_physiolog0.71642603
115MP0005164_abnormal_response_to0.71276866
116MP0003385_abnormal_body_wall0.70355274
117MP0001614_abnormal_blood_vessel0.70127945
118MP0004233_abnormal_muscle_weight0.69988851
119MP0004264_abnormal_extraembryonic_tissu0.69271708
120MP0005193_abnormal_anterior_eye0.69241256
121MP0002269_muscular_atrophy0.69143521
122MP0000751_myopathy0.68708188
123MP0003755_abnormal_palate_morphology0.68673113
124MP0000350_abnormal_cell_proliferation0.68585918
125MP0001697_abnormal_embryo_size0.68535215
126MP0000465_gastrointestinal_hemorrhage0.68484485
127MP0005084_abnormal_gallbladder_morpholo0.68354500
128MP0003045_fibrosis0.67773231
129MP0000343_altered_response_to0.67320651
130MP0004782_abnormal_surfactant_physiolog0.64074577
131MP0002971_abnormal_brown_adipose0.63707222
132MP0000163_abnormal_cartilage_morphology0.63059628
133MP0003300_gastrointestinal_ulcer0.59214667
134MP0002113_abnormal_skeleton_development0.58370801
135MP0000534_abnormal_ureter_morphology0.57292965
136MP0003959_abnormal_lean_body0.56810002

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.33456195
2Protrusio acetabuli (HP:0003179)7.17769246
3Atrophic scars (HP:0001075)4.29479933
4Right ventricular cardiomyopathy (HP:0011663)4.22425854
5Ankle contracture (HP:0006466)4.20202890
6Soft skin (HP:0000977)4.03849579
7Shallow orbits (HP:0000586)4.03543628
8Short nail (HP:0001799)3.90230551
9Aortic dissection (HP:0002647)3.84764780
10Vertebral compression fractures (HP:0002953)3.68757353
11Dilatation of the ascending aorta (HP:0005111)3.65855070
12Fragile skin (HP:0001030)3.56089884
13Cervical subluxation (HP:0003308)3.54724783
14Increased connective tissue (HP:0009025)3.51576833
15Cerebral aneurysm (HP:0004944)3.45786385
16Ulnar bowing (HP:0003031)3.43864934
17Peritonitis (HP:0002586)3.38464375
18Difficulty climbing stairs (HP:0003551)3.30516836
19Muscle fiber splitting (HP:0003555)3.25251706
20Abnormality of dentin (HP:0010299)3.22030061
21Arterial tortuosity (HP:0005116)3.20462871
22Aortic aneurysm (HP:0004942)3.06755865
23Bladder diverticulum (HP:0000015)3.06040503
24Wormian bones (HP:0002645)3.01230973
25Abnormality of the umbilical cord (HP:0010881)2.98695943
26Spinal rigidity (HP:0003306)2.96607333
27Alopecia of scalp (HP:0002293)2.87221614
28Milia (HP:0001056)2.85510739
29Biconcave vertebral bodies (HP:0004586)2.73293626
30Mitral stenosis (HP:0001718)2.73101382
31Trismus (HP:0000211)2.72903522
32Blue sclerae (HP:0000592)2.69555019
33Osteolytic defects of the hand bones (HP:0009699)2.69130009
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.69130009
35Abnormal delivery (HP:0001787)2.68566458
36Selective tooth agenesis (HP:0001592)2.68407433
37Wrist flexion contracture (HP:0001239)2.66465808
38Abnormality of the distal phalanges of the toes (HP:0010182)2.61017514
39Entropion (HP:0000621)2.54112060
40Genu recurvatum (HP:0002816)2.50190288
41Thin bony cortex (HP:0002753)2.46804351
42Pterygium (HP:0001059)2.45818810
43Broad face (HP:0000283)2.45136733
44Distal lower limb muscle weakness (HP:0009053)2.43922217
45Upper limb amyotrophy (HP:0009129)2.43127064
46Distal upper limb amyotrophy (HP:0007149)2.43127064
47Type 1 muscle fiber predominance (HP:0003803)2.38529914
48Abnormality of the Achilles tendon (HP:0005109)2.37528386
49Hyperacusis (HP:0010780)2.31115119
50Abnormality of the calcaneus (HP:0008364)2.31039055
51Broad metatarsal (HP:0001783)2.30474211
52Breech presentation (HP:0001623)2.28903725
53Neonatal short-limb short stature (HP:0008921)2.26741896
54Elbow flexion contracture (HP:0002987)2.25639679
55Natal tooth (HP:0000695)2.25018513
56Areflexia of lower limbs (HP:0002522)2.24796844
57Hyporeflexia of lower limbs (HP:0002600)2.24370029
58Fused cervical vertebrae (HP:0002949)2.23341620
59Onycholysis (HP:0001806)2.21039775
60Bowing of the arm (HP:0006488)2.20633859
61Bowed forearm bones (HP:0003956)2.20633859
62Abnormality of the acetabulum (HP:0003170)2.20381659
63Slender long bone (HP:0003100)2.20166470
64Fragile nails (HP:0001808)2.19190780
65Aortic regurgitation (HP:0001659)2.18983135
66Mitral regurgitation (HP:0001653)2.16416725
67Spinal cord compression (HP:0002176)2.15483975
68Sparse eyelashes (HP:0000653)2.11551559
69Hand muscle atrophy (HP:0009130)2.11076678
70Pili torti (HP:0003777)2.10846046
71Calcaneovalgus deformity (HP:0001848)2.10515923
72Nail dystrophy (HP:0008404)2.09657255
73Rough bone trabeculation (HP:0100670)2.07755189
74Patent foramen ovale (HP:0001655)2.07326504
75Aneurysm (HP:0002617)2.06403793
76Knee flexion contracture (HP:0006380)2.05437647
77Joint laxity (HP:0001388)2.04320495
78Myopathic facies (HP:0002058)2.03277856
79Abnormalities of placenta or umbilical cord (HP:0001194)2.01662999
80Cardiovascular calcification (HP:0011915)2.01290822
81Bowel diverticulosis (HP:0005222)1.98136236
82Abnormal ossification of hand bones (HP:0005921)1.97990613
83Abnormality of carpal bone ossification (HP:0006257)1.97038269
84Generalized amyotrophy (HP:0003700)1.95685361
85Hyperextensible skin (HP:0000974)1.94915196
86Acanthosis nigricans (HP:0000956)1.94655655
87Spondylolisthesis (HP:0003302)1.94181031
88Mitral valve prolapse (HP:0001634)1.93229617
89Coxa vara (HP:0002812)1.91997447
90Ureteral duplication (HP:0000073)1.91914742
91Deformed tarsal bones (HP:0008119)1.90163994
92Back pain (HP:0003418)1.89676055
93Disproportionate tall stature (HP:0001519)1.88470724
94Overgrowth (HP:0001548)1.88416062
95Advanced eruption of teeth (HP:0006288)1.82919229
96Congenital, generalized hypertrichosis (HP:0004540)1.82824615
97Ectopia lentis (HP:0001083)1.82446018
98Reduced subcutaneous adipose tissue (HP:0003758)1.82390242
99Glucose intolerance (HP:0000833)1.82188082
100Ventricular tachycardia (HP:0004756)1.81685861
101Increased variability in muscle fiber diameter (HP:0003557)1.81563375
102Plantar hyperkeratosis (HP:0007556)1.79773030
103Abnormality of oral frenula (HP:0000190)1.79389080
104Joint stiffness (HP:0001387)1.78324725
105Mildly elevated creatine phosphokinase (HP:0008180)1.78259858
106Asymmetry of the thorax (HP:0001555)1.77083882
107Vascular tortuosity (HP:0004948)1.76762716
108Chondrocalcinosis (HP:0000934)1.76484071
109Nonimmune hydrops fetalis (HP:0001790)1.76480657
110Follicular hyperkeratosis (HP:0007502)1.76020435
111Scapular winging (HP:0003691)1.75223119
112Achilles tendon contracture (HP:0001771)1.74679781
113Flat acetabular roof (HP:0003180)1.74674251
114Venous abnormality (HP:0002624)1.74524994
11511 pairs of ribs (HP:0000878)1.74493931
116Thick nail (HP:0001805)1.74351483
117Thin skin (HP:0000963)1.74293907
118Tibial bowing (HP:0002982)1.73758229
119Renal duplication (HP:0000075)1.73532523
120Delayed cranial suture closure (HP:0000270)1.72545404
121Abnormality of skeletal muscle fiber size (HP:0012084)1.72508773
122Round ear (HP:0100830)1.71019318
123Ankyloglossia (HP:0010296)1.70937550
124Distal lower limb amyotrophy (HP:0008944)1.69479781
125Aortic valve stenosis (HP:0001650)1.69209826
126Popliteal pterygium (HP:0009756)1.69039705
127Decreased skull ossification (HP:0004331)1.68280957
128Submucous cleft hard palate (HP:0000176)1.66784266
129Breast hypoplasia (HP:0003187)1.65685544
130Decreased subcutaneous fat (HP:0001002)1.65161894
131Long palpebral fissure (HP:0000637)1.65095018
132Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64820505
133Hypotrichosis (HP:0001006)1.63856794
134Lower limb amyotrophy (HP:0007210)1.63802323
135Abnormality of subcutaneous fat tissue (HP:0001001)1.62578594
136Abnormality of Sharpey fibers (HP:0100685)1.61389860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.79662374
2EPHA23.69404830
3MAPKAPK33.31244782
4LATS23.23851773
5BUB13.14762125
6PIM23.08204713
7PLK42.96128782
8TESK12.28512266
9TTN2.27898900
10WEE12.26465857
11LIMK12.22168259
12PRPF4B2.17039584
13ERN12.16924080
14SIK12.12849366
15STK38L2.09314877
16NME22.07374152
17RPS6KB22.01838169
18EEF2K1.99116576
19ICK1.95826571
20DDR21.85956605
21PKN21.85263241
22NTRK11.80569834
23RIPK11.76882236
24LRRK21.75702390
25MYLK1.71823922
26LATS11.68715138
27TRPM71.65993050
28PAK21.62043071
29MAP3K31.58860925
30SMG11.50240630
31FLT31.47548055
32PDGFRA1.43168906
33TSSK61.42744158
34FER1.42735955
35PAK41.42520702
36ILK1.41983264
37EIF2AK11.36157714
38PTK21.35996709
39RPS6KA41.24382252
40STK101.20188772
41LMTK21.18220789
42ARAF1.16404390
43PAK31.13896090
44BRSK21.12857436
45MST1R1.11564342
46STK31.11087601
47TAOK21.10824298
48PAK11.03780558
49PRKD21.03322091
50NEK11.03310546
51MET1.03047532
52MAP3K61.02385022
53PTK2B1.00813148
54ZAK1.00560720
55STK381.00444173
56PIK3CG0.99481978
57TESK20.98669067
58EIF2AK30.98197373
59PBK0.96652422
60EPHB20.95852080
61PRKCI0.93405752
62NEK20.90657165
63MUSK0.89965791
64PDK40.88414408
65PDK30.88414408
66PTK60.88226374
67PDGFRB0.87930199
68RPS6KA20.87722749
69ERBB40.86235442
70PDK20.84542298
71FGFR40.82725639
72MAP2K10.82123285
73MOS0.81889448
74MAP3K80.78140866
75TTK0.77841892
76STK240.77220853
77IRAK30.76828821
78MTOR0.74671630
79EPHB10.73943728
80PLK30.73603676
81MAPKAPK50.73270294
82AURKA0.73259304
83DYRK30.73000488
84CDK120.72827383
85SCYL20.71517730
86ABL20.69664127
87PDPK10.69263389
88MAP2K30.69102246
89AURKB0.68528313
90MAP3K90.67046116
91PLK10.63945474
92CDK70.62611791
93MAP2K20.62363324
94ROCK10.61439002
95CDC42BPA0.59622155
96MAP3K130.59552040
97DMPK0.59435971
98MAPKAPK20.58882429
99BMX0.57220878
100KSR20.57100390
101PRKD10.55211173
102FGFR10.52563165
103DAPK30.52208107
104AKT30.51710335
105BRSK10.51278133
106RPS6KC10.51151590
107RPS6KL10.51151590
108GSK3A0.50522828
109ROCK20.49532998
110MST40.49203272
111BRAF0.48891343
112MAPK110.48882675
113CAMK2G0.47652335
114KDR0.47630944
115CDK80.47261692
116FRK0.47146119
117MAP3K110.46248721
118MELK0.45235823
119AKT20.45108360
120TBK10.44026372
121TAOK10.42345216
122MAP3K10.41472348
123NEK90.40842070
124EPHA30.40271068
125MAP3K120.40148309
126ZAP700.38002701
127RAF10.36895147
128MAPK70.36028049
129PRKG20.35764687
130ALK0.34319370
131ERBB30.33803207
132RPS6KA60.31603844
133MAPK120.29976509
134STK160.29514896
135CDK60.26213956
136CAMKK20.26066970
137MAP3K50.25703314
138ACVR1B0.25159715
139TGFBR20.24756680
140NME10.23169887
141PIM10.22472890

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.06097067
2ECM-receptor interaction_Homo sapiens_hsa045122.98267812
3p53 signaling pathway_Homo sapiens_hsa041152.61141718
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.44629281
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42469965
6RNA polymerase_Homo sapiens_hsa030202.37388054
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.35081497
8Vitamin B6 metabolism_Homo sapiens_hsa007502.26347149
9Focal adhesion_Homo sapiens_hsa045102.06946442
10Ribosome_Homo sapiens_hsa030102.00406961
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98443550
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88430363
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87166209
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86027220
15RNA transport_Homo sapiens_hsa030131.85116316
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83367783
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79026540
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76538986
19Small cell lung cancer_Homo sapiens_hsa052221.75603867
20Sulfur relay system_Homo sapiens_hsa041221.71880346
21Proteoglycans in cancer_Homo sapiens_hsa052051.69631390
22Cell cycle_Homo sapiens_hsa041101.68836102
23Biosynthesis of amino acids_Homo sapiens_hsa012301.67041667
24Bladder cancer_Homo sapiens_hsa052191.66313142
25Protein digestion and absorption_Homo sapiens_hsa049741.56825799
26Hippo signaling pathway_Homo sapiens_hsa043901.56631485
27Complement and coagulation cascades_Homo sapiens_hsa046101.53846605
28Adherens junction_Homo sapiens_hsa045201.50658548
29Prion diseases_Homo sapiens_hsa050201.48763639
30Regulation of autophagy_Homo sapiens_hsa041401.48300793
31Dilated cardiomyopathy_Homo sapiens_hsa054141.45976117
32Tight junction_Homo sapiens_hsa045301.44851821
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44786700
34Protein export_Homo sapiens_hsa030601.44127704
35Arginine biosynthesis_Homo sapiens_hsa002201.43695955
36Amoebiasis_Homo sapiens_hsa051461.43023924
37Phenylalanine metabolism_Homo sapiens_hsa003601.41597316
38Sphingolipid metabolism_Homo sapiens_hsa006001.28414265
39TGF-beta signaling pathway_Homo sapiens_hsa043501.26141083
40MicroRNAs in cancer_Homo sapiens_hsa052061.25541863
41Arachidonic acid metabolism_Homo sapiens_hsa005901.23501048
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.20896056
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17808806
44Folate biosynthesis_Homo sapiens_hsa007901.15814020
45Shigellosis_Homo sapiens_hsa051311.14664951
46Pyrimidine metabolism_Homo sapiens_hsa002401.12770111
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10872080
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09477854
49Lysosome_Homo sapiens_hsa041421.08857971
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03385136
51Nucleotide excision repair_Homo sapiens_hsa034201.01729355
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01339972
53Carbon metabolism_Homo sapiens_hsa012001.01159930
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99237551
55Malaria_Homo sapiens_hsa051440.97811322
56Pentose phosphate pathway_Homo sapiens_hsa000300.97384783
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92838756
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92197397
59Vitamin digestion and absorption_Homo sapiens_hsa049770.91089887
60Glutathione metabolism_Homo sapiens_hsa004800.88972531
61HIF-1 signaling pathway_Homo sapiens_hsa040660.88094603
62Epstein-Barr virus infection_Homo sapiens_hsa051690.88075256
63Pyruvate metabolism_Homo sapiens_hsa006200.85020575
64Phagosome_Homo sapiens_hsa041450.84592907
65N-Glycan biosynthesis_Homo sapiens_hsa005100.84494523
66Apoptosis_Homo sapiens_hsa042100.83240523
67Sulfur metabolism_Homo sapiens_hsa009200.80618937
68DNA replication_Homo sapiens_hsa030300.79105172
69Prostate cancer_Homo sapiens_hsa052150.78779978
70Vibrio cholerae infection_Homo sapiens_hsa051100.75701981
71Hedgehog signaling pathway_Homo sapiens_hsa043400.75568607
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.75141811
73Ovarian steroidogenesis_Homo sapiens_hsa049130.75029072
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74631794
75AMPK signaling pathway_Homo sapiens_hsa041520.74190223
76Melanoma_Homo sapiens_hsa052180.73933089
77Viral myocarditis_Homo sapiens_hsa054160.73681572
78Spliceosome_Homo sapiens_hsa030400.72328697
79Chronic myeloid leukemia_Homo sapiens_hsa052200.72166410
80HTLV-I infection_Homo sapiens_hsa051660.72137126
81Pathways in cancer_Homo sapiens_hsa052000.71591646
82PPAR signaling pathway_Homo sapiens_hsa033200.71302030
83Renin-angiotensin system_Homo sapiens_hsa046140.71003751
84Purine metabolism_Homo sapiens_hsa002300.70418402
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69542075
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69506573
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.69478455
88Notch signaling pathway_Homo sapiens_hsa043300.69232855
89Galactose metabolism_Homo sapiens_hsa000520.69225698
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.68994535
91Insulin signaling pathway_Homo sapiens_hsa049100.68947533
92Antigen processing and presentation_Homo sapiens_hsa046120.67771237
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65908929
94Fructose and mannose metabolism_Homo sapiens_hsa000510.65764455
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65507865
96Thyroid cancer_Homo sapiens_hsa052160.64291375
97Linoleic acid metabolism_Homo sapiens_hsa005910.63778580
98Renal cell carcinoma_Homo sapiens_hsa052110.63723746
99Mineral absorption_Homo sapiens_hsa049780.63573585
100Tyrosine metabolism_Homo sapiens_hsa003500.62941486
101Basal cell carcinoma_Homo sapiens_hsa052170.60379801
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59210004
103Basal transcription factors_Homo sapiens_hsa030220.58634653
104Viral carcinogenesis_Homo sapiens_hsa052030.58557473
105Lysine degradation_Homo sapiens_hsa003100.57970957
106Endocytosis_Homo sapiens_hsa041440.57504390
107Glioma_Homo sapiens_hsa052140.57290800
108Insulin resistance_Homo sapiens_hsa049310.55079903
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54989177
110Bile secretion_Homo sapiens_hsa049760.54605033
111VEGF signaling pathway_Homo sapiens_hsa043700.54592956
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.54546177
113Toxoplasmosis_Homo sapiens_hsa051450.53691323
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50686491
115Rap1 signaling pathway_Homo sapiens_hsa040150.49409949
116FoxO signaling pathway_Homo sapiens_hsa040680.49230345
117Glucagon signaling pathway_Homo sapiens_hsa049220.49033020
118Base excision repair_Homo sapiens_hsa034100.48431009
119Endometrial cancer_Homo sapiens_hsa052130.48348762
120Platelet activation_Homo sapiens_hsa046110.47873821
121Thyroid hormone synthesis_Homo sapiens_hsa049180.47766591
122Acute myeloid leukemia_Homo sapiens_hsa052210.47463041
123mTOR signaling pathway_Homo sapiens_hsa041500.46914851
124Other glycan degradation_Homo sapiens_hsa005110.46879386
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46640000
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45467910
127Pancreatic cancer_Homo sapiens_hsa052120.45447227
128Gap junction_Homo sapiens_hsa045400.43845368
129GnRH signaling pathway_Homo sapiens_hsa049120.43785236
130Axon guidance_Homo sapiens_hsa043600.42836528
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.42679192
132One carbon pool by folate_Homo sapiens_hsa006700.38496447
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35340144
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34351911
135TNF signaling pathway_Homo sapiens_hsa046680.34131333
136Salmonella infection_Homo sapiens_hsa051320.33161046
137Oocyte meiosis_Homo sapiens_hsa041140.33028993
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32853907
139Hepatitis B_Homo sapiens_hsa051610.32482669

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