ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	imidazole-containing compound metabolic process (GO:0052803)	9.45235165
2	positive regulation of mast cell activation involved in immune response (GO:0033008)	7.03748358
3	positive regulation of mast cell degranulation (GO:0043306)	7.03748358
4	regulation of T cell tolerance induction (GO:0002664)	6.52376296
5	positive regulation of mast cell activation (GO:0033005)	5.66636703
6	regulation of tolerance induction (GO:0002643)	5.60282434
7	T cell apoptotic process (GO:0070231)	5.28578724
8	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	5.23851155
9	regulation of mast cell activation involved in immune response (GO:0033006)	5.21750225
10	angiotensin maturation (GO:0002003)	5.13540810
11	regulation of T cell cytokine production (GO:0002724)	5.00841532
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.98359623
13	positive regulation of leukocyte degranulation (GO:0043302)	4.88031219
14	regulation of mast cell degranulation (GO:0043304)	4.59007286
15	lymphocyte apoptotic process (GO:0070227)	4.43687589
16	cellular biogenic amine biosynthetic process (GO:0042401)	4.17809535
17	amine biosynthetic process (GO:0009309)	4.15411468
18	regulation of mast cell activation (GO:0033003)	4.01155515
19	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.94586452
20	leukocyte apoptotic process (GO:0071887)	3.89634117
21	peroxisome fission (GO:0016559)	3.88966336
22	catecholamine biosynthetic process (GO:0042423)	3.86596911
23	catechol-containing compound biosynthetic process (GO:0009713)	3.86596911
24	regulation of B cell apoptotic process (GO:0002902)	3.59618419
25	regulation of chemokine biosynthetic process (GO:0045073)	3.51442975
26	regulation of myeloid leukocyte mediated immunity (GO:0002886)	3.49784629
27	positive regulation of regulated secretory pathway (GO:1903307)	3.44697052
28	deoxyribonucleotide catabolic process (GO:0009264)	3.37214254
29	deoxyribose phosphate catabolic process (GO:0046386)	3.36555995
30	lipoxygenase pathway (GO:0019372)	3.34030329
31	endosome to pigment granule transport (GO:0043485)	3.33305439
32	endosome to melanosome transport (GO:0035646)	3.33305439
33	regulation of leukocyte degranulation (GO:0043300)	3.32591059
34	ubiquinone biosynthetic process (GO:0006744)	3.28506520
35	purine-containing compound salvage (GO:0043101)	3.21715997
36	purine deoxyribonucleotide catabolic process (GO:0009155)	3.16349571
37	positive regulation of chemokine biosynthetic process (GO:0045080)	3.12912465
38	cellular response to exogenous dsRNA (GO:0071360)	3.10944066
39	pyrimidine nucleotide catabolic process (GO:0006244)	3.10602348
40	purine nucleotide salvage (GO:0032261)	3.06800994
41	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.04692427
42	urate metabolic process (GO:0046415)	3.04272143
43	mature B cell differentiation involved in immune response (GO:0002313)	3.03063058
44	regulation of activated T cell proliferation (GO:0046006)	2.93133543
45	regulation of skeletal muscle contraction (GO:0014819)	2.87777477
46	AMP metabolic process (GO:0046033)	2.85748578
47	quinone biosynthetic process (GO:1901663)	2.85551343
48	regulation of glucokinase activity (GO:0033131)	2.83352553
49	regulation of hexokinase activity (GO:1903299)	2.83352553
50	defense response to protozoan (GO:0042832)	2.81216721
51	negative regulation of B cell apoptotic process (GO:0002903)	2.80823919
52	regulation of oxidative stress-induced neuron death (GO:1903203)	2.79532254
53	valine metabolic process (GO:0006573)	2.78783501
54	replication fork processing (GO:0031297)	2.78419344
55	modulation of growth of symbiont involved in interaction with host (GO:0044144)	2.77684540
56	regulation of growth of symbiont in host (GO:0044126)	2.77684540
57	negative regulation of growth of symbiont in host (GO:0044130)	2.77684540
58	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	2.77684540
59	response to protozoan (GO:0001562)	2.73635460
60	metallo-sulfur cluster assembly (GO:0031163)	2.73544972
61	iron-sulfur cluster assembly (GO:0016226)	2.73544972
62	response to muscle activity (GO:0014850)	2.73150939
63	cellular extravasation (GO:0045123)	2.73078856
64	positive regulation of natural killer cell differentiation (GO:0032825)	2.69892934
65	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.69564409
66	negative regulation of acute inflammatory response (GO:0002674)	2.69084735
67	positive regulation of B cell differentiation (GO:0045579)	2.68520641
68	regulation of proton transport (GO:0010155)	2.68497816
69	cellular metabolic compound salvage (GO:0043094)	2.66077483
70	cellular response to zinc ion (GO:0071294)	2.65873872
71	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.65186469
72	xenobiotic catabolic process (GO:0042178)	2.63869103
73	leukotriene biosynthetic process (GO:0019370)	2.63380862
74	ADP metabolic process (GO:0046031)	2.63259157
75	galactose metabolic process (GO:0006012)	2.61981180
76	ubiquinone metabolic process (GO:0006743)	2.59686515
77	regulation of MHC class II biosynthetic process (GO:0045346)	2.59000590
78	nucleotide salvage (GO:0043173)	2.55490433
79	NAD biosynthetic process (GO:0009435)	2.55289127
80	regulation of regulated secretory pathway (GO:1903305)	2.53312708
81	peptide hormone processing (GO:0016486)	2.52106983
82	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.50951577
83	cytokine biosynthetic process (GO:0042089)	2.50535821
84	negative regulation of mast cell activation (GO:0033004)	2.48028688
85	response to mercury ion (GO:0046689)	2.47534940
86	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.46157568
87	glycogen catabolic process (GO:0005980)	2.45880848
88	regulation of relaxation of muscle (GO:1901077)	2.42061261
89	immunoglobulin mediated immune response (GO:0016064)	2.39755847
90	phenol-containing compound biosynthetic process (GO:0046189)	2.39624239
91	autophagic vacuole fusion (GO:0000046)	2.39543731
92	regulation of cellular carbohydrate catabolic process (GO:0043471)	2.39085624
93	regulation of carbohydrate catabolic process (GO:0043470)	2.39085624
94	response to thyroid hormone (GO:0097066)	2.38802719
95	mannosylation (GO:0097502)	2.38332150
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.38013617
97	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.36287215
98	cytochrome complex assembly (GO:0017004)	2.33930177
99	interleukin-6-mediated signaling pathway (GO:0070102)	2.31131077
100	short-chain fatty acid metabolic process (GO:0046459)	2.29516942

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	9.73512306
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.31508204
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.03861314
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.82572800
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.61339647
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.34978030
7	SCL_19346495_ChIP-Seq_HPC-7_Human	2.33738573
8	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.28980192
9	VDR_21846776_ChIP-Seq_THP-1_Human	2.23000534
10	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.13911893
11	MYB_21317192_ChIP-Seq_ERMYB_Mouse	2.08187443
12	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.04837914
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.04493264
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00731255
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00707209
16	SPI1_23547873_ChIP-Seq_NB4_Human	1.96743888
17	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.85331158
18	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.82616298
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.82232341
20	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.77949055
21	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.77907024
22	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.77368212
23	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.71756383
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.66986341
25	VDR_24763502_ChIP-Seq_THP-1_Human	1.57946296
26	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.56431464
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.54087821
28	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.52962657
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45104107
30	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41834652
31	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.40864196
32	MYB_26560356_Chip-Seq_TH2_Human	1.37136055
33	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36254161
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33659795
35	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.32696064
36	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31391042
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.31270448
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.30379733
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29049715
40	SPI1_23127762_ChIP-Seq_K562_Human	1.28578873
41	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.28202281
42	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.26414109
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26408971
44	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26288673
45	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.25659943
46	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.25144421
47	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23121305
48	UTX_26944678_Chip-Seq_JUKART_Human	1.22323629
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21979217
50	SPI1_20517297_ChIP-Seq_HL60_Human	1.20794646
51	STAT1_20625510_ChIP-Seq_HELA_Human	1.15714451
52	GATA1_22025678_ChIP-Seq_K562_Human	1.13512005
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.13182786
54	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.12606399
55	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.12250265
56	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.11774088
57	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.10577634
58	P300_27268052_Chip-Seq_Bcells_Human	1.09630511
59	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.09608763
60	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.08825372
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08123610
62	BCOR_27268052_Chip-Seq_Bcells_Human	1.06855506
63	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.05520465
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05415817
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.05409043
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.05064338
67	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04323215
68	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04207217
69	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.04076808
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.01253671
71	GATA3_26560356_Chip-Seq_TH2_Human	1.00465858
72	MAF_26560356_Chip-Seq_TH2_Human	1.00396097
73	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.99651008
74	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.99254244
75	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98406600
76	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97138817
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96402314
78	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95674568
79	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.95142051
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94051535
81	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.91852367
82	P68_20966046_ChIP-Seq_HELA_Human	0.91718636
83	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91301890
84	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.90868762
85	MYB_26560356_Chip-Seq_TH1_Human	0.89799875
86	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89476053
87	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.88464984
88	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.88459517
89	OCT4_20526341_ChIP-Seq_ESCs_Human	0.88015207
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.87838018
91	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.87793162
92	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.87594434
93	VDR_24787735_ChIP-Seq_THP-1_Human	0.87501682
94	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87294745
95	IGF1R_20145208_ChIP-Seq_DFB_Human	0.87146883
96	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.87006031
97	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.86635555
98	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.86410979
99	PHF8_20622854_ChIP-Seq_HELA_Human	0.86397272
100	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86226891

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	6.01175262
2	MP0005058_abnormal_lysosome_morphology	3.32751678
3	MP0002735_abnormal_chemical_nociception	3.11906829
4	MP0009697_abnormal_copulation	2.92511692
5	MP0006036_abnormal_mitochondrial_physio	2.86296555
6	MP0005075_abnormal_melanosome_morpholog	2.83094108
7	MP0000372_irregular_coat_pigmentation	2.72613298
8	MP0002148_abnormal_hypersensitivity_rea	2.63710598
9	MP0009840_abnormal_foam_cell	2.58405172
10	MP0000749_muscle_degeneration	2.26738142
11	MP0008058_abnormal_DNA_repair	2.24934958
12	MP0002971_abnormal_brown_adipose	2.15981612
13	MP0005464_abnormal_platelet_physiology	2.15449424
14	MP0000465_gastrointestinal_hemorrhage	2.12204688
15	MP0001835_abnormal_antigen_presentation	2.11824588
16	MP0002837_dystrophic_cardiac_calcinosis	2.04059479
17	MP0005451_abnormal_body_composition	2.00679149
18	MP0002139_abnormal_hepatobiliary_system	1.85369382
19	MP0005397_hematopoietic_system_phenotyp	1.84734492
20	MP0001545_abnormal_hematopoietic_system	1.84734492
21	MP0003646_muscle_fatigue	1.63911219
22	MP0003638_abnormal_response/metabolism_	1.57030208
23	MP0001873_stomach_inflammation	1.55468639
24	MP0009278_abnormal_bone_marrow	1.55111900
25	MP0009115_abnormal_fat_cell	1.54682222
26	MP0003195_calcinosis	1.53143172
27	MP0002419_abnormal_innate_immunity	1.48977291
28	MP0005171_absent_coat_pigmentation	1.48170711
29	MP0003718_maternal_effect	1.48128721
30	MP0001853_heart_inflammation	1.44703638
31	MP0005647_abnormal_sex_gland	1.43379423
32	MP0004036_abnormal_muscle_relaxation	1.40690816
33	MP0005330_cardiomyopathy	1.39650165
34	MP0010094_abnormal_chromosome_stability	1.39115160
35	MP0005319_abnormal_enzyme/_coenzyme	1.37971627
36	MP0005025_abnormal_response_to	1.36850714
37	MP0003183_abnormal_peptide_metabolism	1.32614213
38	MP0003950_abnormal_plasma_membrane	1.30527651
39	MP0005387_immune_system_phenotype	1.27658129
40	MP0001790_abnormal_immune_system	1.27658129
41	MP0006082_CNS_inflammation	1.27049333
42	MP0005448_abnormal_energy_balance	1.26235744
43	MP0005410_abnormal_fertilization	1.23255495
44	MP0005000_abnormal_immune_tolerance	1.21393426
45	MP0003075_altered_response_to	1.18527419
46	MP0009765_abnormal_xenobiotic_induced	1.17043254
47	MP0002420_abnormal_adaptive_immunity	1.16665153
48	MP0008469_abnormal_protein_level	1.16660067
49	MP0001819_abnormal_immune_cell	1.16344179
50	MP0005334_abnormal_fat_pad	1.16197895
51	MP0005166_decreased_susceptibility_to	1.14683786
52	MP0002452_abnormal_antigen_presenting	1.14044594
53	MP0003436_decreased_susceptibility_to	1.13262824
54	MP0002723_abnormal_immune_serum	1.12647895
55	MP0005266_abnormal_metabolism	1.11794851
56	MP0003656_abnormal_erythrocyte_physiolo	1.11435525
57	MP0002405_respiratory_system_inflammati	1.11219479
58	MP0008875_abnormal_xenobiotic_pharmacok	1.09609877
59	MP0005584_abnormal_enzyme/coenzyme_acti	1.08817968
60	MP0004808_abnormal_hematopoietic_stem	1.06086053
61	MP0002970_abnormal_white_adipose	1.05887189
62	MP0000733_abnormal_muscle_development	1.05298732
63	MP0005174_abnormal_tail_pigmentation	1.04811860
64	MP0002733_abnormal_thermal_nociception	1.04756401
65	MP0002269_muscular_atrophy	1.04643044
66	MP0001800_abnormal_humoral_immune	1.03329221
67	MP0000747_muscle_weakness	1.01192041
68	MP0002722_abnormal_immune_system	1.00869178
69	MP0009785_altered_susceptibility_to	1.00788587
70	MP0000681_abnormal_thyroid_gland	0.99370919
71	MP0000716_abnormal_immune_system	0.98402188
72	MP0002108_abnormal_muscle_morphology	0.98118540
73	MP0005332_abnormal_amino_acid	0.97868902
74	MP0008961_abnormal_basal_metabolism	0.96255958
75	MP0001845_abnormal_inflammatory_respons	0.94864180
76	MP0003172_abnormal_lysosome_physiology	0.94495529
77	MP0001764_abnormal_homeostasis	0.94070148
78	MP0001661_extended_life_span	0.93844237
79	MP0002429_abnormal_blood_cell	0.91493951
80	MP0004145_abnormal_muscle_electrophysio	0.91277339
81	MP0003186_abnormal_redox_activity	0.89228894
82	MP0008004_abnormal_stomach_pH	0.88772276
83	MP0002398_abnormal_bone_marrow	0.88659242
84	MP0000689_abnormal_spleen_morphology	0.88255927
85	MP0004084_abnormal_cardiac_muscle	0.87902880
86	MP0002127_abnormal_cardiovascular_syste	0.87870587
87	MP0009763_increased_sensitivity_to	0.87322728
88	MP0003724_increased_susceptibility_to	0.85474923
89	MP0000759_abnormal_skeletal_muscle	0.84724060
90	MP0000343_altered_response_to	0.84682249
91	MP0003763_abnormal_thymus_physiology	0.84049392
92	MP0002118_abnormal_lipid_homeostasis	0.83120201
93	MP0002132_abnormal_respiratory_system	0.81335932
94	MP0001348_abnormal_lacrimal_gland	0.81244798
95	MP0001881_abnormal_mammary_gland	0.80862686
96	MP0002876_abnormal_thyroid_physiology	0.80434038
97	MP0000371_diluted_coat_color	0.79522619
98	MP0002160_abnormal_reproductive_system	0.79101138
99	MP0004087_abnormal_muscle_fiber	0.78550699
100	MP0010329_abnormal_lipoprotein_level	0.78316832

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Exercise-induced myalgia (HP:0003738)	4.31313498
2	Autoimmune thrombocytopenia (HP:0001973)	3.66560112
3	Rhabdomyolysis (HP:0003201)	3.65416897
4	Muscle fiber inclusion bodies (HP:0100299)	3.58194277
5	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.53737098
6	Petechiae (HP:0000967)	3.47881644
7	Male infertility (HP:0003251)	3.21617911
8	Nemaline bodies (HP:0003798)	3.21518163
9	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.15789990
10	Failure to thrive in infancy (HP:0001531)	3.11849210
11	Myoglobinuria (HP:0002913)	3.11565329
12	Reduced antithrombin III activity (HP:0001976)	3.11363201
13	Increased muscle lipid content (HP:0009058)	2.97170099
14	Vacuolated lymphocytes (HP:0001922)	2.96555159
15	Granulocytopenia (HP:0001913)	2.91034471
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.81748224
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.81748224
18	Autoimmune hemolytic anemia (HP:0001890)	2.80624577
19	Type I transferrin isoform profile (HP:0003642)	2.80492562
20	Agammaglobulinemia (HP:0004432)	2.80223397
21	Eosinophilia (HP:0001880)	2.79040549
22	Ragged-red muscle fibers (HP:0003200)	2.76155169
23	Hepatocellular necrosis (HP:0001404)	2.75244668
24	Renal Fanconi syndrome (HP:0001994)	2.75103205
25	Rimmed vacuoles (HP:0003805)	2.74728357
26	Rough bone trabeculation (HP:0100670)	2.74193562
27	EMG: myopathic abnormalities (HP:0003458)	2.67415774
28	Increased intramyocellular lipid droplets (HP:0012240)	2.60808075
29	Abnormality of liposaccharide metabolism (HP:0010968)	2.59681665
30	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.59681665
31	Abnormality of glycolipid metabolism (HP:0010969)	2.59681665
32	Hepatic necrosis (HP:0002605)	2.52806154
33	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.50997387
34	Generalized aminoaciduria (HP:0002909)	2.49607488
35	Abnormality of fatty-acid metabolism (HP:0004359)	2.48545237
36	Premature graying of hair (HP:0002216)	2.44247492
37	Increased CSF lactate (HP:0002490)	2.43992741
38	Thrombocytosis (HP:0001894)	2.41807995
39	Panhypogammaglobulinemia (HP:0003139)	2.41773146
40	Lipid accumulation in hepatocytes (HP:0006561)	2.41187135
41	Increased cerebral lipofuscin (HP:0011813)	2.39776552
42	Muscle hypertrophy of the lower extremities (HP:0008968)	2.39478971
43	Abnormality of the prostate (HP:0008775)	2.38586083
44	Mitochondrial inheritance (HP:0001427)	2.38158209
45	Abnormality of T cell physiology (HP:0011840)	2.34368412
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.33320493
47	Increased serum ferritin (HP:0003281)	2.32195071
48	Distal arthrogryposis (HP:0005684)	2.31678825
49	Muscle stiffness (HP:0003552)	2.31169981
50	Abnormality of eosinophils (HP:0001879)	2.31004860
51	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29469762
52	Hyporeflexia of lower limbs (HP:0002600)	2.26252208
53	Hypokinesia (HP:0002375)	2.26063590
54	Abnormality of transition element cation homeostasis (HP:0011030)	2.25555906
55	Recurrent viral infections (HP:0004429)	2.23380560
56	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.22220907
57	Elevated erythrocyte sedimentation rate (HP:0003565)	2.21568648
58	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.21105957
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.21105957
60	Abnormal protein glycosylation (HP:0012346)	2.21105957
61	Abnormal glycosylation (HP:0012345)	2.21105957
62	Acute necrotizing encephalopathy (HP:0006965)	2.18768842
63	Acute encephalopathy (HP:0006846)	2.18200381
64	Myopathic facies (HP:0002058)	2.17987004
65	Prolonged neonatal jaundice (HP:0006579)	2.16877706
66	Clumsiness (HP:0002312)	2.16531319
67	Calf muscle hypertrophy (HP:0008981)	2.14684222
68	Intrahepatic cholestasis (HP:0001406)	2.11463423
69	Abnormality of the basal ganglia (HP:0002134)	2.10178789
70	Dysostosis multiplex (HP:0000943)	2.09715060
71	Facial diplegia (HP:0001349)	2.05268901
72	Progressive macrocephaly (HP:0004481)	2.04448072
73	Colitis (HP:0002583)	2.04383639
74	Leukocytosis (HP:0001974)	2.04301595
75	Exercise-induced muscle cramps (HP:0003710)	2.03028619
76	Neck muscle weakness (HP:0000467)	2.01420944
77	Chronic mucocutaneous candidiasis (HP:0002728)	2.01378366
78	Recurrent cutaneous fungal infections (HP:0011370)	2.01378366
79	Cerebral edema (HP:0002181)	2.00531523
80	Purpura (HP:0000979)	1.97975642
81	Hyperthyroidism (HP:0000836)	1.96905374
82	Absent thumb (HP:0009777)	1.96239058
83	Abnormality of iron homeostasis (HP:0011031)	1.95657822
84	Obstructive lung disease (HP:0006536)	1.94052802
85	Chronic obstructive pulmonary disease (HP:0006510)	1.94052802
86	Generalized hyperpigmentation (HP:0007440)	1.93748169
87	Orthostatic hypotension (HP:0001278)	1.92843743
88	Lethargy (HP:0001254)	1.90948901
89	Opisthotonus (HP:0002179)	1.90937898
90	Hyperammonemia (HP:0001987)	1.90726605
91	Asymmetric septal hypertrophy (HP:0001670)	1.90055251
92	Abnormal trabecular bone morphology (HP:0100671)	1.89965643
93	Thoracic kyphosis (HP:0002942)	1.89589591
94	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.86820337
95	Bone marrow hypocellularity (HP:0005528)	1.85364234
96	Acute hepatic failure (HP:0006554)	1.84004985
97	Cutaneous melanoma (HP:0012056)	1.81791031
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81486693
99	Dicarboxylic aciduria (HP:0003215)	1.81486693
100	Abnormality of B cell number (HP:0010975)	1.80908867

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	6.74367033
2	OBSCN	4.26152352
3	NME2	3.34651145
4	PINK1	3.09571066
5	FRK	3.00076409
6	IRAK3	2.59854305
7	VRK2	2.53019765
8	MARK3	2.39487097
9	BCKDK	2.30629514
10	TAOK1	2.19191623
11	GRK6	1.95891993
12	MAPKAPK3	1.80610148
13	TBK1	1.80342918
14	KIT	1.71360144
15	SCYL2	1.59188816
16	MAP4K1	1.59019938
17	TYK2	1.58178733
18	MATK	1.50880924
19	TRPM7	1.49427697
20	PIK3CG	1.45465402
21	CSF1R	1.40422586
22	MAP2K3	1.40314808
23	PHKG1	1.36795555
24	PHKG2	1.36795555
25	IKBKE	1.35370793
26	TAOK3	1.34275917
27	FER	1.34196661
28	PDK2	1.33375046
29	RPS6KB2	1.31458583
30	KDR	1.28972118
31	ERN1	1.27671081
32	GRK7	1.24991654
33	ABL2	1.17165807
34	PIM2	1.13706566
35	CCNB1	1.10403616
36	PBK	1.08811500
37	EIF2AK3	1.06776535
38	TESK2	1.05141108
39	MOS	1.03191680
40	MAP3K1	1.02209297
41	IKBKB	1.01202600
42	ZAP70	0.97590400
43	BMPR1B	0.95700157
44	EIF2AK1	0.93088202
45	MAP3K11	0.92285674
46	TGFBR2	0.91523949
47	SYK	0.88915427
48	ARAF	0.84914215
49	BTK	0.83799329
50	MAP2K6	0.82980975
51	STK16	0.82508172
52	DAPK1	0.81295328
53	TAOK2	0.71948450
54	TEC	0.70813847
55	LYN	0.68248379
56	BMPR2	0.67825171
57	TNK2	0.67454975
58	RIPK4	0.64332245
59	ADRBK2	0.64326549
60	MUSK	0.63034216
61	TNIK	0.61448052
62	MAP3K13	0.59497312
63	FES	0.54312357
64	PDK1	0.54091638
65	GRK1	0.54023899
66	CSNK1G3	0.53682386
67	ATR	0.52457754
68	CAMK2G	0.51391565
69	CSNK1A1L	0.51247870
70	HIPK2	0.51068685
71	MAP3K14	0.48305008
72	PIK3CA	0.48154351
73	EEF2K	0.47968036
74	EIF2AK2	0.47749045
75	MAPK12	0.46183758
76	LCK	0.46171116
77	MAPKAPK5	0.45238142
78	GRK5	0.44175126
79	FLT3	0.44015309
80	DAPK2	0.43908797
81	VRK1	0.43457379
82	PRKD2	0.42461318
83	IRAK4	0.41848043
84	CAMK2D	0.41374878
85	BLK	0.41114804
86	TTN	0.40417380
87	PAK1	0.39967893
88	MAP2K2	0.39135938
89	RPS6KA5	0.38658686
90	STK38	0.38257374
91	PRKCQ	0.37362963
92	MYLK	0.35124947
93	PDPK1	0.35020680
94	CSNK1G1	0.34139513
95	CDK3	0.34090220
96	IRAK2	0.33504298
97	ZAK	0.32051367
98	NUAK1	0.31231114
99	ITK	0.30022405
100	AKT2	0.26814049

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.97599923
2	Histidine metabolism_Homo sapiens_hsa00340	3.83317461
3	Other glycan degradation_Homo sapiens_hsa00511	3.71830674
4	Renin-angiotensin system_Homo sapiens_hsa04614	2.78824844
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.46430284
6	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.95624988
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.93408171
8	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.91479477
9	Peroxisome_Homo sapiens_hsa04146	1.82070308
10	DNA replication_Homo sapiens_hsa03030	1.77665048
11	Base excision repair_Homo sapiens_hsa03410	1.74221276
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64709003
13	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.60830511
14	Caffeine metabolism_Homo sapiens_hsa00232	1.60577761
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.57932471
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.57425090
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.56336070
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53791231
19	Proteasome_Homo sapiens_hsa03050	1.49167670
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.48284918
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46347519
22	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41725095
23	Lysosome_Homo sapiens_hsa04142	1.41500436
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40182475
25	Glutathione metabolism_Homo sapiens_hsa00480	1.38959279
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.38808769
27	Homologous recombination_Homo sapiens_hsa03440	1.36040893
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34065077
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31938198
30	Folate biosynthesis_Homo sapiens_hsa00790	1.31656110
31	Arginine biosynthesis_Homo sapiens_hsa00220	1.29770402
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.27486420
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.22780000
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.22509613
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.21579714
36	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.21448779
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20588869
38	Parkinsons disease_Homo sapiens_hsa05012	1.18615977
39	Mismatch repair_Homo sapiens_hsa03430	1.16149413
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15862673
41	Sulfur relay system_Homo sapiens_hsa04122	1.15286423
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.13098072
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.12811840
44	Primary immunodeficiency_Homo sapiens_hsa05340	1.12673257
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.11372125
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09960676
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.05828725
48	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.01972827
49	Purine metabolism_Homo sapiens_hsa00230	1.01285449
50	Galactose metabolism_Homo sapiens_hsa00052	1.00260157
51	Fatty acid degradation_Homo sapiens_hsa00071	0.96886064
52	Sulfur metabolism_Homo sapiens_hsa00920	0.94776574
53	Allograft rejection_Homo sapiens_hsa05330	0.94741854
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.91726471
55	Butanoate metabolism_Homo sapiens_hsa00650	0.91600956
56	Carbon metabolism_Homo sapiens_hsa01200	0.88719796
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.88109359
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.87832754
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85300037
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.84970564
61	Fatty acid elongation_Homo sapiens_hsa00062	0.79216693
62	Metabolic pathways_Homo sapiens_hsa01100	0.77721689
63	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76027168
64	RNA polymerase_Homo sapiens_hsa03020	0.73405139
65	Leishmaniasis_Homo sapiens_hsa05140	0.72550005
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71946544
67	Legionellosis_Homo sapiens_hsa05134	0.70864255
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.70848888
69	Platelet activation_Homo sapiens_hsa04611	0.69958532
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69924532
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.64647166
72	Alzheimers disease_Homo sapiens_hsa05010	0.61772369
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.58443318
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57456264
75	Phototransduction_Homo sapiens_hsa04744	0.56822199
76	Olfactory transduction_Homo sapiens_hsa04740	0.56759297
77	One carbon pool by folate_Homo sapiens_hsa00670	0.56507834
78	Propanoate metabolism_Homo sapiens_hsa00640	0.56141992
79	Retinol metabolism_Homo sapiens_hsa00830	0.54634543
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53854125
81	Pertussis_Homo sapiens_hsa05133	0.52590213
82	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.52363934
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51746726
84	Huntingtons disease_Homo sapiens_hsa05016	0.49289346
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45446131
86	Hepatitis C_Homo sapiens_hsa05160	0.44630877
87	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43580649
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43398591
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42319849
90	Ribosome_Homo sapiens_hsa03010	0.41006002
91	Insulin resistance_Homo sapiens_hsa04931	0.39816254
92	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.39348851
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37752668
94	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37670088
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.34084924
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33975001
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32981548
98	Osteoclast differentiation_Homo sapiens_hsa04380	0.30176687
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.29811745
100	Tuberculosis_Homo sapiens_hsa05152	0.28109486

FTCDNL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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