FTH1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prenylation (GO:0097354)6.56168723
2protein prenylation (GO:0018342)6.56168723
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)6.19583838
4valine metabolic process (GO:0006573)5.40350580
5signal peptide processing (GO:0006465)5.29623727
6amino acid salvage (GO:0043102)5.19185690
7L-methionine salvage (GO:0071267)5.19185690
8L-methionine biosynthetic process (GO:0071265)5.19185690
9protein neddylation (GO:0045116)4.59820025
10behavioral response to nicotine (GO:0035095)4.46823814
11seminiferous tubule development (GO:0072520)4.20866949
12adaptation of signaling pathway (GO:0023058)4.06951510
13regulation of germinal center formation (GO:0002634)4.02675581
14establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.96142903
15mitochondrion transport along microtubule (GO:0047497)3.96142903
16DNA deamination (GO:0045006)3.75793800
17methionine biosynthetic process (GO:0009086)3.69223820
18branched-chain amino acid catabolic process (GO:0009083)3.68009683
19macroautophagy (GO:0016236)3.55755960
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54893678
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54893678
22negative regulation of thymocyte apoptotic process (GO:0070244)3.52998767
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44747668
24negative regulation of cell killing (GO:0031342)3.44747668
25cytokinetic process (GO:0032506)3.43125521
26protein complex biogenesis (GO:0070271)3.36820154
27establishment of mitochondrion localization (GO:0051654)3.36295041
28neutrophil activation involved in immune response (GO:0002283)3.28961851
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17734770
30RNA destabilization (GO:0050779)3.16640296
31platelet dense granule organization (GO:0060155)3.16152852
32pyrimidine-containing compound transmembrane transport (GO:0072531)3.14758903
33rRNA methylation (GO:0031167)3.13351036
34kynurenine metabolic process (GO:0070189)3.12800488
35ATP synthesis coupled proton transport (GO:0015986)3.06386692
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.06386692
37methionine metabolic process (GO:0006555)3.04397057
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04321535
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03156379
40GTP biosynthetic process (GO:0006183)3.02635385
41indolalkylamine metabolic process (GO:0006586)3.02497506
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02273379
43indolalkylamine catabolic process (GO:0046218)3.02249859
44tryptophan catabolic process (GO:0006569)3.02249859
45indole-containing compound catabolic process (GO:0042436)3.02249859
46branched-chain amino acid metabolic process (GO:0009081)3.01584996
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00723755
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99848952
49cytochrome complex assembly (GO:0017004)2.99129737
50negative regulation of interleukin-1 beta production (GO:0032691)2.93044064
51rRNA modification (GO:0000154)2.92550150
52tryptophan metabolic process (GO:0006568)2.88022169
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82422281
54negative regulation of T-helper cell differentiation (GO:0045623)2.82422281
55positive regulation of prostaglandin secretion (GO:0032308)2.81631474
56cardiovascular system development (GO:0072358)2.81108093
57nucleoside diphosphate phosphorylation (GO:0006165)2.80456372
58cardiolipin metabolic process (GO:0032048)2.79542935
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79084836
60amine catabolic process (GO:0009310)2.76118959
61cellular biogenic amine catabolic process (GO:0042402)2.76118959
62regulation of triglyceride catabolic process (GO:0010896)2.75604876
63response to interferon-beta (GO:0035456)2.74046826
64mitochondrial respiratory chain complex assembly (GO:0033108)2.74042756
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72507606
66L-fucose catabolic process (GO:0042355)2.70487014
67fucose catabolic process (GO:0019317)2.70487014
68L-fucose metabolic process (GO:0042354)2.70487014
69benzene-containing compound metabolic process (GO:0042537)2.69368423
70cellular response to interferon-beta (GO:0035458)2.68518318
71mannosylation (GO:0097502)2.67122550
72mast cell activation (GO:0045576)2.66382307
73multicellular organism reproduction (GO:0032504)2.64576365
74negative regulation of heart rate (GO:0010459)2.63529244
75preassembly of GPI anchor in ER membrane (GO:0016254)2.63235707
76positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63070689
77positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.62981952
78aspartate family amino acid biosynthetic process (GO:0009067)2.62194646
79leukocyte degranulation (GO:0043299)2.61697471
80phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.60703580
81regulation of cGMP metabolic process (GO:0030823)2.60659264
82negative regulation of mast cell activation (GO:0033004)2.58853039
83mast cell degranulation (GO:0043303)2.58182604
84mast cell activation involved in immune response (GO:0002279)2.58182604
85protein localization to cilium (GO:0061512)2.58011428
86respiratory chain complex IV assembly (GO:0008535)2.56515217
87GPI anchor metabolic process (GO:0006505)2.55925075
88cellular response to exogenous dsRNA (GO:0071360)2.55067337
89negative regulation of interleukin-1 production (GO:0032692)2.52480689
90positive regulation of defense response to virus by host (GO:0002230)2.51816552
91ribosomal small subunit biogenesis (GO:0042274)2.48360364
92heme transport (GO:0015886)2.45205884
93base-excision repair, AP site formation (GO:0006285)2.43789456
94negative regulation of membrane potential (GO:0045837)2.41962586
95positive regulation of respiratory burst (GO:0060267)2.40589187
96pyrimidine nucleotide catabolic process (GO:0006244)2.39439681
97neutrophil activation (GO:0042119)2.38722917
98regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38499117
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38492047
100ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.35687242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.84109846
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.63299696
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.53477089
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22303894
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.98960024
6VDR_22108803_ChIP-Seq_LS180_Human2.75096501
7ZNF274_21170338_ChIP-Seq_K562_Hela2.58889788
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.56600862
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.56065954
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46181304
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36061012
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32476259
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09755953
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04744384
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01927319
16EZH2_22144423_ChIP-Seq_EOC_Human1.89122844
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85280973
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81342337
19IRF1_19129219_ChIP-ChIP_H3396_Human1.75699277
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74728114
21AR_21572438_ChIP-Seq_LNCaP_Human1.72912421
22STAT1_20625510_ChIP-Seq_HELA_Human1.72252658
23RUNX_20019798_ChIP-Seq_JUKART_Human1.69315818
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65567643
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.62277192
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59749417
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59473645
28FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59040800
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.59040800
30GATA3_21878914_ChIP-Seq_MCF-7_Human1.56880817
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56631034
32VDR_23849224_ChIP-Seq_CD4+_Human1.52392337
33TP53_22573176_ChIP-Seq_HFKS_Human1.51296285
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46994989
35FOXP3_21729870_ChIP-Seq_TREG_Human1.46104663
36FOXA1_21572438_ChIP-Seq_LNCaP_Human1.45926612
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.45514259
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.44517082
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44087463
40TAF15_26573619_Chip-Seq_HEK293_Human1.43657764
41AR_20517297_ChIP-Seq_VCAP_Human1.42878060
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.41321930
43GATA3_26560356_Chip-Seq_TH2_Human1.39748979
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.39678565
45SOX2_19829295_ChIP-Seq_ESCs_Human1.39374925
46NANOG_19829295_ChIP-Seq_ESCs_Human1.39374925
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37452861
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.37338407
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37321190
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34444217
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33259123
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31720635
53ER_23166858_ChIP-Seq_MCF-7_Human1.28134699
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27486856
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27073004
56TAF2_19829295_ChIP-Seq_ESCs_Human1.26850605
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26755305
58NANOG_20526341_ChIP-Seq_ESCs_Human1.24524398
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.24377287
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24322497
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22786556
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18522031
63CBP_20019798_ChIP-Seq_JUKART_Human1.18522031
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17821178
65FOXH1_21741376_ChIP-Seq_ESCs_Human1.17628160
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16780721
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15039938
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12811849
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.12795050
70SPI1_20517297_ChIP-Seq_HL60_Human1.12674123
71ERA_21632823_ChIP-Seq_H3396_Human1.09260462
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.07598136
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07358025
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05473248
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.04823504
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04502763
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04431492
78SOX2_21211035_ChIP-Seq_LN229_Human1.04252216
79BCL6_27268052_Chip-Seq_Bcells_Human1.03163101
80GATA3_27048872_Chip-Seq_THYMUS_Human1.03104301
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02032245
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01910129
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98016899
84SPI1_23547873_ChIP-Seq_NB4_Human0.97379931
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97112027
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96495623
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95826073
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95401271
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95236082
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94865633
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.94358501
92MYC_19829295_ChIP-Seq_ESCs_Human0.93271769
93ERG_20517297_ChIP-Seq_VCAP_Human0.93074769
94MYB_26560356_Chip-Seq_TH2_Human0.92101518
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90838375
96OCT4_20526341_ChIP-Seq_ESCs_Human0.89939070
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.89599066
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89203448
99HOXB7_26014856_ChIP-Seq_BT474_Human0.88986525
100RBPJ_21746931_ChIP-Seq_IB4_Human0.88349871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.29458815
2MP0003646_muscle_fatigue4.06832792
3MP0001545_abnormal_hematopoietic_system3.34121506
4MP0005397_hematopoietic_system_phenotyp3.34121506
5MP0003724_increased_susceptibility_to2.98118774
6MP0005671_abnormal_response_to2.52858831
7MP0001835_abnormal_antigen_presentation2.47998069
8MP0005084_abnormal_gallbladder_morpholo2.36220958
9MP0002837_dystrophic_cardiac_calcinosis2.35997225
10MP0008872_abnormal_physiological_respon2.11670378
11MP0005503_abnormal_tendon_morphology2.02072828
12MP0009764_decreased_sensitivity_to1.99270299
13MP0005464_abnormal_platelet_physiology1.91834841
14MP0006292_abnormal_olfactory_placode1.87457461
15MP0008877_abnormal_DNA_methylation1.85972148
16MP0002148_abnormal_hypersensitivity_rea1.79792450
17MP0003283_abnormal_digestive_organ1.77736573
18MP0000372_irregular_coat_pigmentation1.74392616
19MP0002638_abnormal_pupillary_reflex1.63837083
20MP0001501_abnormal_sleep_pattern1.62817231
21MP0001968_abnormal_touch/_nociception1.60332027
22MP0005000_abnormal_immune_tolerance1.55508184
23MP0005174_abnormal_tail_pigmentation1.54829719
24MP0005551_abnormal_eye_electrophysiolog1.49166838
25MP0001919_abnormal_reproductive_system1.46356827
26MP0009785_altered_susceptibility_to1.45580879
27MP0009840_abnormal_foam_cell1.42518216
28MP0003638_abnormal_response/metabolism_1.41252823
29MP0002736_abnormal_nociception_after1.40655958
30MP0008875_abnormal_xenobiotic_pharmacok1.39165771
31MP0002723_abnormal_immune_serum1.36128997
32MP0004145_abnormal_muscle_electrophysio1.35656157
33MP0003011_delayed_dark_adaptation1.35575628
34MP0005167_abnormal_blood-brain_barrier1.33465147
35MP0002452_abnormal_antigen_presenting1.33358370
36MP0004142_abnormal_muscle_tone1.32158339
37MP0001845_abnormal_inflammatory_respons1.32139116
38MP0003879_abnormal_hair_cell1.32089723
39MP0003303_peritoneal_inflammation1.29636256
40MP0002419_abnormal_innate_immunity1.23136620
41MP0005410_abnormal_fertilization1.23042650
42MP0003252_abnormal_bile_duct1.22723128
43MP0001800_abnormal_humoral_immune1.22294274
44MP0001790_abnormal_immune_system1.18891445
45MP0005387_immune_system_phenotype1.18891445
46MP0002420_abnormal_adaptive_immunity1.16311128
47MP0001819_abnormal_immune_cell1.14289620
48MP0005646_abnormal_pituitary_gland1.14064761
49MP0003787_abnormal_imprinting1.12198631
50MP0002254_reproductive_system_inflammat1.12113869
51MP0009046_muscle_twitch1.11001206
52MP0002095_abnormal_skin_pigmentation1.10465355
53MP0008995_early_reproductive_senescence1.08487759
54MP0002876_abnormal_thyroid_physiology1.07567603
55MP0005075_abnormal_melanosome_morpholog1.07544074
56MP0001663_abnormal_digestive_system1.06700235
57MP0003195_calcinosis1.06152957
58MP0003186_abnormal_redox_activity1.05559947
59MP0000685_abnormal_immune_system1.05145257
60MP0006036_abnormal_mitochondrial_physio1.02539850
61MP0004742_abnormal_vestibular_system1.00210902
62MP0002102_abnormal_ear_morphology0.97985814
63MP0001970_abnormal_pain_threshold0.97124853
64MP0003436_decreased_susceptibility_to0.96731827
65MP0005645_abnormal_hypothalamus_physiol0.96719642
66MP0000230_abnormal_systemic_arterial0.96150719
67MP0005025_abnormal_response_to0.95248675
68MP0001984_abnormal_olfaction0.95100896
69MP0008775_abnormal_heart_ventricle0.94743591
70MP0010386_abnormal_urinary_bladder0.94597738
71MP0005389_reproductive_system_phenotype0.94497633
72MP0005085_abnormal_gallbladder_physiolo0.94254235
73MP0010155_abnormal_intestine_physiology0.94135931
74MP0003718_maternal_effect0.90258137
75MP0008469_abnormal_protein_level0.89424106
76MP0009765_abnormal_xenobiotic_induced0.89193632
77MP0006082_CNS_inflammation0.88006674
78MP0003136_yellow_coat_color0.87751354
79MP0006072_abnormal_retinal_apoptosis0.87173866
80MP0009333_abnormal_splenocyte_physiolog0.87083561
81MP0000689_abnormal_spleen_morphology0.85373467
82MP0002998_abnormal_bone_remodeling0.85153456
83MP0010329_abnormal_lipoprotein_level0.85128763
84MP0001873_stomach_inflammation0.84620130
85MP0005377_hearing/vestibular/ear_phenot0.84431641
86MP0003878_abnormal_ear_physiology0.84431641
87MP0008004_abnormal_stomach_pH0.84117745
88MP0002272_abnormal_nervous_system0.83370737
89MP0000716_abnormal_immune_system0.83130561
90MP0004381_abnormal_hair_follicle0.82582794
91MP0002653_abnormal_ependyma_morphology0.82566296
92MP0001533_abnormal_skeleton_physiology0.81998864
93MP0002398_abnormal_bone_marrow0.81042863
94MP0005636_abnormal_mineral_homeostasis0.79546885
95MP0001756_abnormal_urination0.79206871
96MP0002733_abnormal_thermal_nociception0.78787177
97MP0002938_white_spotting0.78121211
98MP0002229_neurodegeneration0.73688574
99MP0006035_abnormal_mitochondrial_morpho0.71913062
100MP0002429_abnormal_blood_cell0.71269302

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)8.46063178
2Decreased central vision (HP:0007663)6.66267046
3Abnormal rod and cone electroretinograms (HP:0008323)5.87345323
4Pendular nystagmus (HP:0012043)5.16673159
5Acanthocytosis (HP:0001927)5.15137079
6Attenuation of retinal blood vessels (HP:0007843)4.73836304
7Keratoconus (HP:0000563)4.54075765
8Increased corneal curvature (HP:0100692)4.54075765
9Disinhibition (HP:0000734)4.18182097
10Acute hepatic failure (HP:0006554)3.71055868
11Agitation (HP:0000713)3.42837287
12Increased hepatocellular lipid droplets (HP:0006565)3.39821907
13Personality changes (HP:0000751)3.24345664
14Abolished electroretinogram (ERG) (HP:0000550)3.17191803
15Lipid accumulation in hepatocytes (HP:0006561)3.11637307
16Self-mutilation (HP:0000742)3.11464905
17Acute necrotizing encephalopathy (HP:0006965)3.08214644
18Renal Fanconi syndrome (HP:0001994)2.99759847
19Abnormality of lateral ventricle (HP:0030047)2.85861873
20Increased intramyocellular lipid droplets (HP:0012240)2.85355322
21Abnormal mitochondria in muscle tissue (HP:0008316)2.84730542
22Exertional dyspnea (HP:0002875)2.80799490
23Poikilocytosis (HP:0004447)2.77592641
24Mitochondrial inheritance (HP:0001427)2.76984654
25Inappropriate behavior (HP:0000719)2.72448555
26Elevated erythrocyte sedimentation rate (HP:0003565)2.71843330
27Progressive macrocephaly (HP:0004481)2.68024795
28Metaphyseal dysplasia (HP:0100255)2.60263412
29Acute encephalopathy (HP:0006846)2.59135382
30Irregular epiphyses (HP:0010582)2.54543641
31Cerebral hypomyelination (HP:0006808)2.52924126
32Macular degeneration (HP:0000608)2.51631550
33Disproportionate short-trunk short stature (HP:0003521)2.48125370
34Increased CSF lactate (HP:0002490)2.44338116
35Increased muscle lipid content (HP:0009058)2.42485606
36Optic disc pallor (HP:0000543)2.40159403
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34437873
38Prolonged bleeding time (HP:0003010)2.33153691
39Psychosis (HP:0000709)2.30269051
40Dyskinesia (HP:0100660)2.28475799
41Type II lissencephaly (HP:0007260)2.27186482
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18434801
43Abnormality of renal resorption (HP:0011038)2.16508905
44Stomach cancer (HP:0012126)2.16082380
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12312733
46Congenital stationary night blindness (HP:0007642)2.11751315
47Carpal bone hypoplasia (HP:0001498)2.09985752
48Abnormality of the renal cortex (HP:0011035)2.08668159
49Petechiae (HP:0000967)2.06469228
50Nephronophthisis (HP:0000090)2.06095864
51Vasculitis (HP:0002633)2.04911581
52Renal cortical cysts (HP:0000803)2.04279356
53IgG deficiency (HP:0004315)2.02270598
54Lissencephaly (HP:0001339)2.02036927
55Delayed CNS myelination (HP:0002188)2.01278550
56Hyperphosphaturia (HP:0003109)2.00895263
57Delusions (HP:0000746)1.97408684
58Congenital, generalized hypertrichosis (HP:0004540)1.94795796
59Choreoathetosis (HP:0001266)1.91197271
60Purpura (HP:0000979)1.88556121
61Pallor (HP:0000980)1.87685523
62Molar tooth sign on MRI (HP:0002419)1.82349611
63Abnormality of midbrain morphology (HP:0002418)1.82349611
64Medial flaring of the eyebrow (HP:0010747)1.81530212
65Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80813432
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80813432
67Pancreatic cysts (HP:0001737)1.80400021
68Stomatitis (HP:0010280)1.80055619
69Restlessness (HP:0000711)1.79800204
70Aplasia of the musculature (HP:0100854)1.78537046
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78497210
72Infantile muscular hypotonia (HP:0008947)1.77198434
73Bony spicule pigmentary retinopathy (HP:0007737)1.76307183
74Hepatocellular necrosis (HP:0001404)1.74556171
75Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74019243
76Drooling (HP:0002307)1.73953543
77Eosinophilia (HP:0001880)1.73630886
78Aplastic anemia (HP:0001915)1.72021649
79Oligomenorrhea (HP:0000876)1.71245082
80Glycosuria (HP:0003076)1.69195084
81Abnormality of urine glucose concentration (HP:0011016)1.69195084
82Opisthotonus (HP:0002179)1.68372410
83Leukocytosis (HP:0001974)1.67216070
84Methylmalonic acidemia (HP:0002912)1.66112493
85Genu varum (HP:0002970)1.65293450
86Alveolar cell carcinoma (HP:0006519)1.64220850
87Excessive salivation (HP:0003781)1.64200863
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63820528
89Abnormal drinking behavior (HP:0030082)1.63199947
90Polydipsia (HP:0001959)1.63199947
91CNS hypomyelination (HP:0003429)1.61676145
92Gaze-evoked nystagmus (HP:0000640)1.60897884
93Radial bowing (HP:0002986)1.60600344
94Abnormality of the renal medulla (HP:0100957)1.60400047
953-Methylglutaconic aciduria (HP:0003535)1.60295042
96Abnormality of the costochondral junction (HP:0000919)1.59920249
97Abnormality of alanine metabolism (HP:0010916)1.59358946
98Hyperalaninemia (HP:0003348)1.59358946
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59358946
100Pancreatic fibrosis (HP:0100732)1.57433109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.47995904
2NME24.35054479
3BMPR23.21982750
4NUAK12.98498329
5ZAK2.87373647
6CDK192.80549859
7TIE12.78839376
8RIPK42.58920191
9BCKDK2.29100668
10TLK12.21781085
11FRK2.18167458
12MAP4K12.18068448
13MST42.15673271
14GRK12.08316408
15TXK1.99313248
16ADRBK21.94101846
17WNK31.92800172
18WNK41.91607297
19GRK61.90186444
20BMPR1B1.86416563
21MAP4K21.68986348
22OXSR11.61972944
23MAP3K141.59079146
24MAP3K111.42482290
25ACVR1B1.41230065
26EIF2AK11.39452569
27MAP2K71.39451725
28TEC1.37956292
29MAP3K41.36641871
30KIT1.34885536
31TYK21.31049418
32LATS11.24921553
33IKBKB1.16294846
34FLT31.14292732
35PAK31.12916035
36TNK21.10301814
37FER1.07026790
38PINK11.03113137
39INSRR1.01598471
40MAP3K120.98316838
41STK160.97363391
42PRKD30.96505981
43JAK10.94061071
44DYRK20.90470951
45JAK30.90381937
46RPS6KA50.84298547
47MAPKAPK50.82849444
48MAPKAPK30.82334826
49PIK3CG0.77574170
50MAP2K20.75533943
51ADRBK10.74142381
52PRKCQ0.72960339
53TNIK0.70407273
54SYK0.69866126
55AKT30.67568196
56LCK0.66027830
57CAMKK20.62814276
58MUSK0.62675290
59FES0.62254767
60MYLK0.61263215
61NLK0.59640454
62BTK0.57649962
63PIM20.54931999
64CSNK1G30.54168562
65PIM10.53878847
66PRKCG0.51263631
67MARK30.49693138
68TRPM70.49577471
69CSNK1G10.48567928
70PAK10.48062948
71ABL20.47975170
72STK390.47708762
73PRKACA0.45319354
74CSF1R0.44648410
75ITK0.44531042
76PRKCI0.44230940
77LYN0.43657087
78CSNK1A1L0.42691630
79CHUK0.42562385
80IKBKE0.41099550
81IRAK30.41059356
82MATK0.40414010
83VRK10.39171078
84KDR0.38171256
85GRK70.38016254
86MAPK130.36771939
87DYRK30.36266801
88EIF2AK30.35435373
89PRKACG0.35072091
90PTK2B0.34689391
91CAMKK10.34240110
92PKN10.30937818
93PRKCZ0.30859023
94GRK50.30781250
95MAP2K10.30465019
96JAK20.29925766
97ABL10.28393666
98CSNK1G20.27394511
99PRKG10.25922577
100PRKCA0.25550157

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.23998964
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.96980687
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.79620448
4Allograft rejection_Homo sapiens_hsa053302.79535380
5Graft-versus-host disease_Homo sapiens_hsa053322.69685164
6Oxidative phosphorylation_Homo sapiens_hsa001902.61985698
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53922555
8Type I diabetes mellitus_Homo sapiens_hsa049402.53452614
9Phototransduction_Homo sapiens_hsa047442.51864521
10Autoimmune thyroid disease_Homo sapiens_hsa053202.40590548
11Ribosome_Homo sapiens_hsa030102.30233033
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17433100
13Parkinsons disease_Homo sapiens_hsa050121.98183001
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.95121655
15Rheumatoid arthritis_Homo sapiens_hsa053231.90829613
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80140783
17Selenocompound metabolism_Homo sapiens_hsa004501.76050790
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74623705
19RNA polymerase_Homo sapiens_hsa030201.71232792
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65849682
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51866067
22Staphylococcus aureus infection_Homo sapiens_hsa051501.47472412
23Olfactory transduction_Homo sapiens_hsa047401.44653900
24Linoleic acid metabolism_Homo sapiens_hsa005911.43098010
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37874336
26Nitrogen metabolism_Homo sapiens_hsa009101.37242613
27RNA degradation_Homo sapiens_hsa030181.36436388
28Collecting duct acid secretion_Homo sapiens_hsa049661.30392413
29Sulfur metabolism_Homo sapiens_hsa009201.29110263
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28262607
31Proteasome_Homo sapiens_hsa030501.25346399
32Alzheimers disease_Homo sapiens_hsa050101.21880616
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13783104
34Hematopoietic cell lineage_Homo sapiens_hsa046401.13226280
35Primary immunodeficiency_Homo sapiens_hsa053401.12928442
36One carbon pool by folate_Homo sapiens_hsa006701.12082559
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11867902
38Arachidonic acid metabolism_Homo sapiens_hsa005901.09039496
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07282990
40Leishmaniasis_Homo sapiens_hsa051401.04705786
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00673456
42Antigen processing and presentation_Homo sapiens_hsa046121.00151410
43Huntingtons disease_Homo sapiens_hsa050160.99420722
44Tryptophan metabolism_Homo sapiens_hsa003800.98978037
45Protein export_Homo sapiens_hsa030600.95903200
46Sulfur relay system_Homo sapiens_hsa041220.94087788
47Chemical carcinogenesis_Homo sapiens_hsa052040.93239530
48Cardiac muscle contraction_Homo sapiens_hsa042600.92362148
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.89743154
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89667061
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87968082
52ABC transporters_Homo sapiens_hsa020100.87904615
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84023379
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83724041
55Caffeine metabolism_Homo sapiens_hsa002320.82071683
56Pancreatic secretion_Homo sapiens_hsa049720.81431349
57Ether lipid metabolism_Homo sapiens_hsa005650.80298467
58Viral myocarditis_Homo sapiens_hsa054160.80208303
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79109799
60Tuberculosis_Homo sapiens_hsa051520.77938926
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.77755036
62Phagosome_Homo sapiens_hsa041450.73579229
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71892659
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.69546493
65Pyrimidine metabolism_Homo sapiens_hsa002400.69094716
66Mineral absorption_Homo sapiens_hsa049780.68568666
67Herpes simplex infection_Homo sapiens_hsa051680.68183340
68Systemic lupus erythematosus_Homo sapiens_hsa053220.68023285
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65768096
70Purine metabolism_Homo sapiens_hsa002300.64485487
71African trypanosomiasis_Homo sapiens_hsa051430.64035131
72Pertussis_Homo sapiens_hsa051330.62468408
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59576083
74Regulation of autophagy_Homo sapiens_hsa041400.59242662
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.59207167
76Retinol metabolism_Homo sapiens_hsa008300.57015691
77Morphine addiction_Homo sapiens_hsa050320.56951036
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55326939
79Homologous recombination_Homo sapiens_hsa034400.54167322
80Glutathione metabolism_Homo sapiens_hsa004800.53654025
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51555818
82Peroxisome_Homo sapiens_hsa041460.51032703
83Lysosome_Homo sapiens_hsa041420.50891114
84Salivary secretion_Homo sapiens_hsa049700.49709812
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.49102840
86Fat digestion and absorption_Homo sapiens_hsa049750.46636174
87Taste transduction_Homo sapiens_hsa047420.45732496
88Metabolic pathways_Homo sapiens_hsa011000.45659563
89Butanoate metabolism_Homo sapiens_hsa006500.43693115
90Serotonergic synapse_Homo sapiens_hsa047260.43134480
91Platelet activation_Homo sapiens_hsa046110.42937541
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.42675904
93Malaria_Homo sapiens_hsa051440.41930618
94Nicotine addiction_Homo sapiens_hsa050330.41254782
95Protein digestion and absorption_Homo sapiens_hsa049740.39367048
96Glycerolipid metabolism_Homo sapiens_hsa005610.35784965
97Influenza A_Homo sapiens_hsa051640.33579909
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32312914
99Legionellosis_Homo sapiens_hsa051340.31876341
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31719781

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