FTH1P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)6.20551043
2cytidine catabolic process (GO:0006216)6.20551043
3cytidine deamination (GO:0009972)6.20551043
4pyrimidine ribonucleoside catabolic process (GO:0046133)5.90821589
5DNA deamination (GO:0045006)5.53868261
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.70786633
7eosinophil chemotaxis (GO:0048245)4.22574124
8Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86068036
9eosinophil migration (GO:0072677)3.81215327
10energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65660971
11ATP synthesis coupled proton transport (GO:0015986)3.65660971
12regulation of regulatory T cell differentiation (GO:0045589)3.59050627
13actin nucleation (GO:0045010)3.54481656
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53929261
15protein neddylation (GO:0045116)3.51403873
16immunoglobulin mediated immune response (GO:0016064)3.50992858
17pyrimidine nucleoside catabolic process (GO:0046135)3.46019270
18platelet dense granule organization (GO:0060155)3.44130662
19cellular response to exogenous dsRNA (GO:0071360)3.31973237
20regulation of activation of Janus kinase activity (GO:0010533)3.20431246
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11952466
22sequestering of actin monomers (GO:0042989)3.10243777
23regulation of B cell receptor signaling pathway (GO:0050855)3.10081877
24regulation of chronic inflammatory response (GO:0002676)3.00746576
25positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87370400
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84491035
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84491035
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83084582
29positive regulation of calcium-mediated signaling (GO:0050850)2.80646572
30positive regulation of antigen processing and presentation (GO:0002579)2.79363176
31positive regulation of lymphocyte migration (GO:2000403)2.78101350
32positive regulation of interleukin-8 secretion (GO:2000484)2.76179955
33B cell mediated immunity (GO:0019724)2.75704803
34response to interferon-beta (GO:0035456)2.73733517
35negative regulation of mast cell activation (GO:0033004)2.73448492
36negative regulation of viral genome replication (GO:0045071)2.73193771
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72120009
38positive regulation of prostaglandin secretion (GO:0032308)2.71687237
39regulation of antigen processing and presentation (GO:0002577)2.71184665
40regulation of interleukin-8 secretion (GO:2000482)2.70466037
41positive regulation of interleukin-17 production (GO:0032740)2.68448808
42positive thymic T cell selection (GO:0045059)2.67052961
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66740053
44positive regulation of T cell migration (GO:2000406)2.64665165
45positive regulation of monocyte chemotaxis (GO:0090026)2.63375192
46negative regulation of T cell apoptotic process (GO:0070233)2.62966212
47positive regulation of defense response to virus by host (GO:0002230)2.62581809
48T cell costimulation (GO:0031295)2.62166540
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.61830941
50regulation of T cell mediated cytotoxicity (GO:0001914)2.60197579
51lymphocyte costimulation (GO:0031294)2.59467730
52positive regulation of respiratory burst (GO:0060267)2.58603712
53pyrimidine-containing compound catabolic process (GO:0072529)2.57763151
54natural killer cell activation involved in immune response (GO:0002323)2.56530940
55electron transport chain (GO:0022900)2.54661615
56respiratory electron transport chain (GO:0022904)2.54463314
57negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.53091049
58positive regulation of activated T cell proliferation (GO:0042104)2.53080981
59negative regulation by host of viral transcription (GO:0043922)2.52616928
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50729842
61amine catabolic process (GO:0009310)2.49570755
62cellular biogenic amine catabolic process (GO:0042402)2.49570755
63leukocyte degranulation (GO:0043299)2.48025375
64cellular response to zinc ion (GO:0071294)2.43973145
65protein complex biogenesis (GO:0070271)2.43115460
66positive regulation of interferon-gamma production (GO:0032729)2.41089503
67granulocyte activation (GO:0036230)2.39959460
68hydrogen ion transmembrane transport (GO:1902600)2.39662883
69regulation of T cell tolerance induction (GO:0002664)2.39335325
70regulation of cellular extravasation (GO:0002691)2.39275773
71killing of cells of other organism (GO:0031640)2.38425964
72disruption of cells of other organism (GO:0044364)2.38425964
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38369709
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.37719595
75regulation of T cell migration (GO:2000404)2.36906943
76proton transport (GO:0015992)2.36759634
77positive regulation of interleukin-1 beta secretion (GO:0050718)2.36461833
78neutrophil activation (GO:0042119)2.36408952
79neutrophil activation involved in immune response (GO:0002283)2.36060875
80cellular response to interferon-beta (GO:0035458)2.35603940
81regulation of immunoglobulin secretion (GO:0051023)2.35411418
82mast cell activation (GO:0045576)2.35114320
83negative regulation of lymphocyte apoptotic process (GO:0070229)2.35058956
84positive regulation of B cell differentiation (GO:0045579)2.34459896
85interferon-gamma-mediated signaling pathway (GO:0060333)2.33028304
86behavioral response to nicotine (GO:0035095)2.32650250
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.32287265
88hydrogen transport (GO:0006818)2.31742130
89tryptophan catabolic process (GO:0006569)2.31390018
90indole-containing compound catabolic process (GO:0042436)2.31390018
91indolalkylamine catabolic process (GO:0046218)2.31390018
92regulation of cellular amino acid metabolic process (GO:0006521)2.28241255
93regulation of defense response to virus by host (GO:0050691)2.27246752
94regulation of interleukin-1 beta secretion (GO:0050706)2.25790185
95pyrimidine ribonucleoside metabolic process (GO:0046131)2.24690019
96positive regulation of T cell apoptotic process (GO:0070234)2.24109379
97positive regulation of interleukin-1 secretion (GO:0050716)2.23970100
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.23417491
99ATP hydrolysis coupled proton transport (GO:0015991)2.23417491
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.22092574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.44095049
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74190179
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05667625
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30866244
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05770228
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.85202356
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.49578199
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39321165
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35672553
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26582457
11VDR_22108803_ChIP-Seq_LS180_Human2.26544665
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16205887
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01441474
14ZNF274_21170338_ChIP-Seq_K562_Hela1.85036563
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.79228848
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74882147
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69756642
18GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57843625
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57326734
20BCL6_27268052_Chip-Seq_Bcells_Human1.57287754
21EZH2_22144423_ChIP-Seq_EOC_Human1.56798191
22PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.56560261
23GATA3_26560356_Chip-Seq_TH2_Human1.54386609
24LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54323465
25TAF2_19829295_ChIP-Seq_ESCs_Human1.53002782
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52175678
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51736134
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49964289
29TP53_22573176_ChIP-Seq_HFKS_Human1.47947728
30MYB_26560356_Chip-Seq_TH2_Human1.47063457
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46377292
32AR_20517297_ChIP-Seq_VCAP_Human1.44376474
33NANOG_20526341_ChIP-Seq_ESCs_Human1.43722359
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37548620
35IGF1R_20145208_ChIP-Seq_DFB_Human1.37466470
36STAT1_20625510_ChIP-Seq_HELA_Human1.35638835
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32918661
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31675965
39RUNX_20019798_ChIP-Seq_JUKART_Human1.31031978
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.30254063
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30254063
42VDR_23849224_ChIP-Seq_CD4+_Human1.26156602
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25845102
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24389867
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24056693
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.23066080
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.22943514
48GATA3_27048872_Chip-Seq_THYMUS_Human1.20577646
49MYC_19829295_ChIP-Seq_ESCs_Human1.20149746
50NCOR_22424771_ChIP-Seq_293T_Human1.19629189
51NANOG_19829295_ChIP-Seq_ESCs_Human1.19477256
52SOX2_19829295_ChIP-Seq_ESCs_Human1.19477256
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.19081873
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17836556
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17718641
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.17642987
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15838961
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15143408
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15130284
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14339891
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12276122
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11945514
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.11706994
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09202771
65CTCF_20526341_ChIP-Seq_ESCs_Human1.09126666
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08823499
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08676067
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08340756
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.08306644
70P53_21459846_ChIP-Seq_SAOS-2_Human1.07603009
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07132095
72P300_27268052_Chip-Seq_Bcells_Human1.06045725
73ERG_20517297_ChIP-Seq_VCAP_Human1.05821655
74SPI1_23547873_ChIP-Seq_NB4_Human1.05265173
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04168445
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03633575
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03128869
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02829199
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.02780528
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00512906
81MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00330183
82FOXP3_21729870_ChIP-Seq_TREG_Human0.99991084
83ERA_21632823_ChIP-Seq_H3396_Human0.99396155
84FOXH1_21741376_ChIP-Seq_ESCs_Human0.98697604
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97485565
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96510571
87BCOR_27268052_Chip-Seq_Bcells_Human0.95360622
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.95109896
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.94584501
90SA1_27219007_Chip-Seq_Bcells_Human0.94458379
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92964648
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92504990
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91338272
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.91295029
95OCT4_20526341_ChIP-Seq_ESCs_Human0.91078204
96HTT_18923047_ChIP-ChIP_STHdh_Human0.88276162
97SOX2_21211035_ChIP-Seq_LN229_Human0.84385406
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83684627
99E2F1_20622854_ChIP-Seq_HELA_Human0.83538179
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83455795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.82577092
2MP0001835_abnormal_antigen_presentation3.56944731
3MP0005084_abnormal_gallbladder_morpholo3.25349248
4MP0003724_increased_susceptibility_to2.95015157
5MP0002148_abnormal_hypersensitivity_rea2.80126373
6MP0009785_altered_susceptibility_to2.52675719
7MP0004147_increased_porphyrin_level2.32932722
8MP0005464_abnormal_platelet_physiology2.27142431
9MP0005000_abnormal_immune_tolerance2.16059067
10MP0005360_urolithiasis2.13294810
11MP0001790_abnormal_immune_system2.10576400
12MP0005387_immune_system_phenotype2.10576400
13MP0006082_CNS_inflammation2.09458259
14MP0001800_abnormal_humoral_immune2.05176591
15MP0009764_decreased_sensitivity_to1.99659619
16MP0005025_abnormal_response_to1.97899130
17MP0003806_abnormal_nucleotide_metabolis1.95857732
18MP0010155_abnormal_intestine_physiology1.91629567
19MP0003252_abnormal_bile_duct1.85653906
20MP0002723_abnormal_immune_serum1.83577497
21MP0005645_abnormal_hypothalamus_physiol1.81550512
22MP0002452_abnormal_antigen_presenting1.69759158
23MP0002420_abnormal_adaptive_immunity1.68862144
24MP0001819_abnormal_immune_cell1.67776158
25MP0003866_abnormal_defecation1.62686299
26MP0000372_irregular_coat_pigmentation1.59256901
27MP0000465_gastrointestinal_hemorrhage1.59010430
28MP0000685_abnormal_immune_system1.56403231
29MP0009333_abnormal_splenocyte_physiolog1.53772118
30MP0001919_abnormal_reproductive_system1.53074322
31MP0002139_abnormal_hepatobiliary_system1.52700522
32MP0001873_stomach_inflammation1.52416906
33MP0003436_decreased_susceptibility_to1.52413281
34MP0001845_abnormal_inflammatory_respons1.50009919
35MP0008872_abnormal_physiological_respon1.48991083
36MP0002876_abnormal_thyroid_physiology1.46994020
37MP0005646_abnormal_pituitary_gland1.46278924
38MP0009379_abnormal_foot_pigmentation1.44675296
39MP0002166_altered_tumor_susceptibility1.41473363
40MP0002419_abnormal_innate_immunity1.39506079
41MP0002095_abnormal_skin_pigmentation1.37343659
42MP0002102_abnormal_ear_morphology1.32466680
43MP0003646_muscle_fatigue1.32445913
44MP0008995_early_reproductive_senescence1.32227915
45MP0002138_abnormal_hepatobiliary_system1.25233851
46MP0008875_abnormal_xenobiotic_pharmacok1.23618482
47MP0000716_abnormal_immune_system1.23471751
48MP0002736_abnormal_nociception_after1.21608009
49MP0005085_abnormal_gallbladder_physiolo1.20690615
50MP0001905_abnormal_dopamine_level1.19761608
51MP0002006_tumorigenesis1.17778594
52MP0002398_abnormal_bone_marrow1.16194116
53MP0003011_delayed_dark_adaptation1.14359317
54MP0001968_abnormal_touch/_nociception1.12769971
55MP0008469_abnormal_protein_level1.12520668
56MP0002877_abnormal_melanocyte_morpholog1.11181166
57MP0002837_dystrophic_cardiac_calcinosis1.09724388
58MP0002822_catalepsy1.08996057
59MP0009840_abnormal_foam_cell1.07779465
60MP0003763_abnormal_thymus_physiology1.07397330
61MP0001663_abnormal_digestive_system1.06578866
62MP0001853_heart_inflammation1.04789586
63MP0005075_abnormal_melanosome_morpholog1.04513179
64MP0003303_peritoneal_inflammation1.04179657
65MP0005389_reproductive_system_phenotype1.02566803
66MP0002429_abnormal_blood_cell1.01059385
67MP0000689_abnormal_spleen_morphology1.00033864
68MP0002653_abnormal_ependyma_morphology0.99733192
69MP0004019_abnormal_vitamin_homeostasis0.99134108
70MP0005636_abnormal_mineral_homeostasis0.99027930
71MP0005410_abnormal_fertilization0.98781093
72MP0002405_respiratory_system_inflammati0.97665102
73MP0001764_abnormal_homeostasis0.96373785
74MP0003195_calcinosis0.94973718
75MP0006276_abnormal_autonomic_nervous0.93162011
76MP0005166_decreased_susceptibility_to0.92714220
77MP0005551_abnormal_eye_electrophysiolog0.91865071
78MP0001533_abnormal_skeleton_physiology0.91374242
79MP0002277_abnormal_respiratory_mucosa0.90522135
80MP0009763_increased_sensitivity_to0.90028430
81MP0006072_abnormal_retinal_apoptosis0.89355946
82MP0000230_abnormal_systemic_arterial0.89281087
83MP0005381_digestive/alimentary_phenotyp0.89109592
84MP0000343_altered_response_to0.88837838
85MP0005167_abnormal_blood-brain_barrier0.88511051
86MP0009643_abnormal_urine_homeostasis0.87950680
87MP0008004_abnormal_stomach_pH0.87590095
88MP0001501_abnormal_sleep_pattern0.87191319
89MP0003878_abnormal_ear_physiology0.85023424
90MP0005377_hearing/vestibular/ear_phenot0.85023424
91MP0002722_abnormal_immune_system0.84763587
92MP0001666_abnormal_nutrient_absorption0.84621618
93MP0005408_hypopigmentation0.84420043
94MP0001664_abnormal_digestion0.84198982
95MP0003186_abnormal_redox_activity0.83322453
96MP0004142_abnormal_muscle_tone0.82893410
97MP0002733_abnormal_thermal_nociception0.82155906
98MP0005332_abnormal_amino_acid0.81734559
99MP0003787_abnormal_imprinting0.81365894
100MP0003075_altered_response_to0.79850565

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.59854467
2Alveolar cell carcinoma (HP:0006519)3.75617274
3Mitochondrial inheritance (HP:0001427)3.46282412
4Acute necrotizing encephalopathy (HP:0006965)3.39358434
5Aplastic anemia (HP:0001915)3.26945651
6Abnormal mitochondria in muscle tissue (HP:0008316)3.20053426
7Neoplasm of the tracheobronchial system (HP:0100552)3.19549995
8IgG deficiency (HP:0004315)3.16493636
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.07519526
10Decreased electroretinogram (ERG) amplitude (HP:0000654)3.05012087
11Hepatocellular necrosis (HP:0001404)3.04327528
12Hepatic necrosis (HP:0002605)3.01488827
13Stomatitis (HP:0010280)2.98407407
14Increased intramyocellular lipid droplets (HP:0012240)2.96906464
15Acute encephalopathy (HP:0006846)2.96641118
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89855161
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89855161
18Pulmonary infiltrates (HP:0002113)2.88542429
19Increased CSF lactate (HP:0002490)2.86457439
20Congenital stationary night blindness (HP:0007642)2.85068218
21Hypoproteinemia (HP:0003075)2.81105335
22Progressive macrocephaly (HP:0004481)2.79729111
23Abnormality of the prostate (HP:0008775)2.77240197
24Decreased central vision (HP:0007663)2.75669452
253-Methylglutaconic aciduria (HP:0003535)2.73171135
26Petechiae (HP:0000967)2.71832211
27Increased IgM level (HP:0003496)2.69465392
28Increased muscle lipid content (HP:0009058)2.66979024
29Increased hepatocellular lipid droplets (HP:0006565)2.63973888
30Abnormality of T cell number (HP:0011839)2.62181415
31Obstructive lung disease (HP:0006536)2.61235622
32Chronic obstructive pulmonary disease (HP:0006510)2.61235622
33Lipid accumulation in hepatocytes (HP:0006561)2.60437361
34T lymphocytopenia (HP:0005403)2.59660608
35Abnormality of T cells (HP:0002843)2.58599763
36Chronic diarrhea (HP:0002028)2.52305665
37Generalized aminoaciduria (HP:0002909)2.52305167
38Renal Fanconi syndrome (HP:0001994)2.47591250
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44739975
40Exertional dyspnea (HP:0002875)2.40301599
41Abolished electroretinogram (ERG) (HP:0000550)2.40194724
42Abnormality of urine glucose concentration (HP:0011016)2.37904242
43Glycosuria (HP:0003076)2.37904242
44Cerebral edema (HP:0002181)2.36668283
45Meningitis (HP:0001287)2.34342846
46Hemoptysis (HP:0002105)2.31925677
47Severe combined immunodeficiency (HP:0004430)2.30149156
48Cerebral palsy (HP:0100021)2.26495144
49Abnormality of B cell number (HP:0010975)2.26169036
50Nausea (HP:0002018)2.21176005
51Lethargy (HP:0001254)2.20085440
52Purpura (HP:0000979)2.19069800
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17664441
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17651986
55Lactic acidosis (HP:0003128)2.15571368
56Abnormality of T cell physiology (HP:0011840)2.14395146
57Abnormal rod and cone electroretinograms (HP:0008323)2.12316908
58Dicarboxylic aciduria (HP:0003215)2.12054763
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12054763
60Chest pain (HP:0100749)2.06888022
61Autoimmune hemolytic anemia (HP:0001890)2.04637343
62Abnormality of the pleura (HP:0002103)2.03408538
63Encephalitis (HP:0002383)2.01603173
64Vasculitis (HP:0002633)2.01046563
65Methylmalonic aciduria (HP:0012120)2.01031838
66Thyroiditis (HP:0100646)2.01011905
67Increased serum ferritin (HP:0003281)2.00346307
68Myositis (HP:0100614)2.00296651
69Abnormality of transition element cation homeostasis (HP:0011030)1.99123758
70Optic disc pallor (HP:0000543)1.98252271
71Abnormality of iron homeostasis (HP:0011031)1.97925912
72Increased serum lactate (HP:0002151)1.97783606
73Agitation (HP:0000713)1.96162856
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95783557
75Abnormality of alanine metabolism (HP:0010916)1.95783557
76Hyperalaninemia (HP:0003348)1.95783557
77Tongue fasciculations (HP:0001308)1.95661351
78Hypoalbuminemia (HP:0003073)1.93507379
79Abnormal albumin level (HP:0012116)1.93507379
80Attenuation of retinal blood vessels (HP:0007843)1.92854077
81Congenital sensorineural hearing impairment (HP:0008527)1.92691233
82Type 2 muscle fiber atrophy (HP:0003554)1.92373070
83Molar tooth sign on MRI (HP:0002419)1.90875197
84Abnormality of midbrain morphology (HP:0002418)1.90875197
85Type II lissencephaly (HP:0007260)1.89531060
86Pancreatitis (HP:0001733)1.89344035
87Abnormality of eosinophils (HP:0001879)1.89201922
88B lymphocytopenia (HP:0010976)1.87867388
89Epistaxis (HP:0000421)1.87566635
90Renal cortical cysts (HP:0000803)1.86904843
91Progressive neurologic deterioration (HP:0002344)1.86900466
92Agammaglobulinemia (HP:0004432)1.85660276
93Prolonged bleeding time (HP:0003010)1.84453993
94Ketosis (HP:0001946)1.84169970
95Systemic lupus erythematosus (HP:0002725)1.83199209
96Autoimmune thrombocytopenia (HP:0001973)1.81789975
97Type I transferrin isoform profile (HP:0003642)1.81556709
98Reduced antithrombin III activity (HP:0001976)1.80924636
99Abnormality of macrophages (HP:0004311)1.78504585
100Hyperphosphaturia (HP:0003109)1.77876101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.29653312
2TESK23.36085961
3KDR3.07975141
4BCKDK2.74372396
5TAOK32.64975320
6MAP4K22.59482626
7ADRBK22.29173235
8TLK12.27766635
9MAP4K12.00534757
10TEC1.90269869
11BMPR21.89945218
12ZAK1.83912102
13ITK1.80607338
14GRK11.80142417
15SYK1.71904713
16IKBKB1.68009174
17PIM21.67212612
18MATK1.65579238
19MST41.62870422
20MAP3K111.53808677
21TAF11.50877558
22VRK21.45996969
23MAP3K121.45927056
24JAK31.42011548
25GRK61.41578426
26KIT1.41042606
27FES1.40764121
28ACVR1B1.38635155
29PINK11.35534358
30GRK71.33678748
31MAP2K71.28029436
32RIPK41.25872419
33MAP3K51.23595592
34BTK1.23050942
35TESK11.22446782
36NUAK11.20156617
37TIE11.18112814
38BMPR1B1.17947810
39MYLK1.17866323
40BLK1.16912398
41PRKCI1.13253366
42LIMK11.13025439
43LYN1.10864467
44CSF1R1.09169108
45MAPKAPK31.02779933
46IKBKE1.00313504
47TBK10.99610030
48INSRR0.99016387
49CDK190.98307528
50LCK0.97226891
51FRK0.95425314
52PRKCQ0.94123780
53CSNK1G30.92814700
54CSK0.86339133
55DAPK10.81999567
56DYRK20.81880289
57DAPK20.78300542
58VRK10.76524601
59GRK50.75881437
60ZAP700.74987055
61MUSK0.74768031
62OXSR10.73903944
63STK38L0.73241932
64ADRBK10.71957335
65WNK30.71811832
66STK240.71754640
67RPS6KA50.69238962
68PIM10.67213981
69DAPK30.67188980
70CSNK1G20.65621367
71TRIM280.65216278
72SCYL20.63921941
73PIK3CG0.62152645
74TNK20.61122964
75WNK40.58368727
76MAPK130.57339935
77CSNK1A1L0.57147760
78PRKCA0.54983402
79CSNK1G10.54724671
80MAP3K40.53755666
81ABL20.50276383
82CAMKK20.49028400
83OBSCN0.48418957
84PRKACA0.48302696
85STK160.46689558
86IGF1R0.45610729
87PRKCD0.44934832
88ARAF0.43143440
89PRKCE0.42360034
90CAMK2A0.40697032
91ABL10.40078088
92BCR0.39965309
93FYN0.39005833
94PKN10.35677942
95MAP3K140.34704582
96PRKACG0.34621969
97CSNK2A10.33241647
98ERBB20.32656924
99MAP2K20.31755069
100AURKA0.31095073

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.03162691
2Graft-versus-host disease_Homo sapiens_hsa053323.76850714
3Allograft rejection_Homo sapiens_hsa053303.74501439
4Autoimmune thyroid disease_Homo sapiens_hsa053203.62421583
5Type I diabetes mellitus_Homo sapiens_hsa049403.22981788
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.10318711
7Oxidative phosphorylation_Homo sapiens_hsa001902.71067675
8Primary immunodeficiency_Homo sapiens_hsa053402.59166120
9Proteasome_Homo sapiens_hsa030502.45587110
10Rheumatoid arthritis_Homo sapiens_hsa053232.42652211
11Antigen processing and presentation_Homo sapiens_hsa046122.30118409
12Parkinsons disease_Homo sapiens_hsa050122.14852462
13Staphylococcus aureus infection_Homo sapiens_hsa051501.94500601
14Hematopoietic cell lineage_Homo sapiens_hsa046401.92549564
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91218106
16Sulfur metabolism_Homo sapiens_hsa009201.90245904
17Linoleic acid metabolism_Homo sapiens_hsa005911.78913861
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75547567
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45560323
20Viral myocarditis_Homo sapiens_hsa054161.37933263
21Collecting duct acid secretion_Homo sapiens_hsa049661.33384442
22Fat digestion and absorption_Homo sapiens_hsa049751.29555977
23Alzheimers disease_Homo sapiens_hsa050101.27903881
24Protein export_Homo sapiens_hsa030601.24798179
25Arachidonic acid metabolism_Homo sapiens_hsa005901.24062386
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23486386
27Caffeine metabolism_Homo sapiens_hsa002321.22912961
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22646545
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15478628
30Phototransduction_Homo sapiens_hsa047441.14779337
31Leishmaniasis_Homo sapiens_hsa051401.14619633
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12449319
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10438278
34Huntingtons disease_Homo sapiens_hsa050161.05559869
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02354436
36Chemical carcinogenesis_Homo sapiens_hsa052041.01955709
37Ribosome_Homo sapiens_hsa030101.00192645
38Vitamin digestion and absorption_Homo sapiens_hsa049770.96682146
39Nitrogen metabolism_Homo sapiens_hsa009100.92439399
40Regulation of autophagy_Homo sapiens_hsa041400.91979407
41Peroxisome_Homo sapiens_hsa041460.90075256
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89263644
43Systemic lupus erythematosus_Homo sapiens_hsa053220.89122590
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.87643641
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.85931958
46Tryptophan metabolism_Homo sapiens_hsa003800.85797282
47Cardiac muscle contraction_Homo sapiens_hsa042600.84347303
48RNA polymerase_Homo sapiens_hsa030200.81655695
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80287373
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79491915
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77944283
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77686702
53Mineral absorption_Homo sapiens_hsa049780.77556309
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.77428187
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76624062
56Butanoate metabolism_Homo sapiens_hsa006500.75507396
57Retinol metabolism_Homo sapiens_hsa008300.71743581
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69295088
59Ether lipid metabolism_Homo sapiens_hsa005650.68768299
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.68605882
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66892721
62Phagosome_Homo sapiens_hsa041450.65017343
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64151449
64Olfactory transduction_Homo sapiens_hsa047400.63554140
65Herpes simplex infection_Homo sapiens_hsa051680.62744985
66Tuberculosis_Homo sapiens_hsa051520.62702020
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57209710
68Salmonella infection_Homo sapiens_hsa051320.54779423
69Glutathione metabolism_Homo sapiens_hsa004800.54619010
70Pertussis_Homo sapiens_hsa051330.53463358
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51736200
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.51206836
73Pyrimidine metabolism_Homo sapiens_hsa002400.49776561
74Malaria_Homo sapiens_hsa051440.47470961
75T cell receptor signaling pathway_Homo sapiens_hsa046600.45350593
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45242551
77Lysosome_Homo sapiens_hsa041420.44432190
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44409595
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44157324
80Renin-angiotensin system_Homo sapiens_hsa046140.43512032
81Fatty acid elongation_Homo sapiens_hsa000620.43460284
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.41927231
83Fructose and mannose metabolism_Homo sapiens_hsa000510.41691894
84Metabolic pathways_Homo sapiens_hsa011000.40353671
85Homologous recombination_Homo sapiens_hsa034400.39181584
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38732194
87Chemokine signaling pathway_Homo sapiens_hsa040620.37085561
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36869169
89Propanoate metabolism_Homo sapiens_hsa006400.36064496
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35344211
91Purine metabolism_Homo sapiens_hsa002300.33104300
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.31438358
93African trypanosomiasis_Homo sapiens_hsa051430.30442791
94Shigellosis_Homo sapiens_hsa051310.30413082
95Glycerolipid metabolism_Homo sapiens_hsa005610.28877417
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28234676
97Serotonergic synapse_Homo sapiens_hsa047260.28060591
98Legionellosis_Homo sapiens_hsa051340.26034847
99Synaptic vesicle cycle_Homo sapiens_hsa047210.24838648
100beta-Alanine metabolism_Homo sapiens_hsa004100.21873556

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