FTH1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.31811932
2cytidine metabolic process (GO:0046087)6.31811932
3cytidine catabolic process (GO:0006216)6.31811932
4DNA deamination (GO:0045006)5.45926453
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.45915408
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.39317378
7interferon-gamma production (GO:0032609)4.96721540
8eosinophil chemotaxis (GO:0048245)4.41785269
9protein neddylation (GO:0045116)4.28861370
10regulation of activation of Janus kinase activity (GO:0010533)4.22389410
11eosinophil migration (GO:0072677)3.95681882
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.94404882
13regulation of chronic inflammatory response (GO:0002676)3.71134956
14sequestering of actin monomers (GO:0042989)3.64217296
15pyrimidine nucleoside catabolic process (GO:0046135)3.60446338
16positive regulation of monocyte chemotaxis (GO:0090026)3.58941706
17actin nucleation (GO:0045010)3.56391989
18granulocyte activation (GO:0036230)3.52167340
19positive regulation of T cell apoptotic process (GO:0070234)3.49077980
20regulation of regulatory T cell differentiation (GO:0045589)3.49007056
21neutrophil activation involved in immune response (GO:0002283)3.48218655
22negative regulation of T cell apoptotic process (GO:0070233)3.32531547
23neutrophil activation (GO:0042119)3.22009184
24macrophage chemotaxis (GO:0048246)3.18484440
25immunoglobulin mediated immune response (GO:0016064)3.15827999
26positive regulation of lymphocyte apoptotic process (GO:0070230)3.11576024
27positive regulation of lymphocyte migration (GO:2000403)3.04953334
28regulation of mononuclear cell migration (GO:0071675)3.03640227
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98485962
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96939633
31negative regulation by host of viral transcription (GO:0043922)2.93519270
32positive regulation of systemic arterial blood pressure (GO:0003084)2.91267955
33positive regulation of defense response to virus by host (GO:0002230)2.89075652
34monocyte chemotaxis (GO:0002548)2.88853395
35regulation of lymphocyte chemotaxis (GO:1901623)2.87128284
36positive regulation of interleukin-8 secretion (GO:2000484)2.85453756
37positive regulation of gamma-delta T cell activation (GO:0046645)2.83057163
38positive regulation of calcium-mediated signaling (GO:0050850)2.82758919
39T cell costimulation (GO:0031295)2.82249733
40platelet dense granule organization (GO:0060155)2.82008146
41cellular biogenic amine catabolic process (GO:0042402)2.81397324
42amine catabolic process (GO:0009310)2.81397324
43adaptation of signaling pathway (GO:0023058)2.81079981
44lymphocyte costimulation (GO:0031294)2.78282370
45positive regulation of interleukin-1 beta secretion (GO:0050718)2.77333618
46negative regulation of viral genome replication (GO:0045071)2.76180312
47regulation of vitamin D biosynthetic process (GO:0060556)2.73998818
48negative regulation of heart rate (GO:0010459)2.72616993
49regulation of T cell apoptotic process (GO:0070232)2.68555386
50pyrimidine-containing compound catabolic process (GO:0072529)2.68389187
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66427920
52regulation of B cell receptor signaling pathway (GO:0050855)2.66295869
53regulation of T cell tolerance induction (GO:0002664)2.64298126
54positive regulation of B cell differentiation (GO:0045579)2.62255589
55negative regulation of mast cell activation (GO:0033004)2.61679050
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60794584
57positive regulation of interleukin-1 secretion (GO:0050716)2.60108195
58autophagic vacuole fusion (GO:0000046)2.59549114
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.58498072
60lymphocyte chemotaxis (GO:0048247)2.56881057
61positive regulation of T cell migration (GO:2000406)2.55859563
62negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54992727
63regulation of interleukin-1 beta secretion (GO:0050706)2.54980390
64positive thymic T cell selection (GO:0045059)2.53408384
65regulation of leukocyte mediated cytotoxicity (GO:0001910)2.51685954
66regulation of vitamin metabolic process (GO:0030656)2.51389045
67regulation of T cell mediated cytotoxicity (GO:0001914)2.50587150
68positive regulation of natural killer cell mediated immunity (GO:0002717)2.49767242
69B cell mediated immunity (GO:0019724)2.48798919
70regulation of monocyte chemotaxis (GO:0090025)2.45735379
71regulation of interleukin-8 secretion (GO:2000482)2.45679619
72positive regulation of tolerance induction (GO:0002645)2.43431589
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.43430967
74regulation of natural killer cell mediated immunity (GO:0002715)2.42977462
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.42977462
76positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.41873319
77ATP synthesis coupled proton transport (GO:0015986)2.41786808
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41786808
79negative regulation of lymphocyte apoptotic process (GO:0070229)2.41184148
80respiratory electron transport chain (GO:0022904)2.38797304
81regulation of lymphocyte migration (GO:2000401)2.38222142
82negative regulation of interleukin-12 production (GO:0032695)2.37820638
83T cell migration (GO:0072678)2.37494496
84regulation of antigen processing and presentation (GO:0002577)2.37056875
85electron transport chain (GO:0022900)2.37017913
86polyamine metabolic process (GO:0006595)2.36757406
87negative regulation of interleukin-1 beta production (GO:0032691)2.36723607
88regulation of macrophage chemotaxis (GO:0010758)2.36118418
89regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.35443214
90organelle membrane fusion (GO:0090174)2.35206107
91indolalkylamine catabolic process (GO:0046218)2.35131865
92tryptophan catabolic process (GO:0006569)2.35131865
93indole-containing compound catabolic process (GO:0042436)2.35131865
94positive regulation of antigen processing and presentation (GO:0002579)2.32816061
95regulation of calcium-mediated signaling (GO:0050848)2.31612500
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.31175269
97regulation of cell killing (GO:0031341)2.31172236
98regulation of T cell migration (GO:2000404)2.30556655
99positive regulation of cell killing (GO:0031343)2.29073754
100regulation of urine volume (GO:0035809)2.28816797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.27602888
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.13347217
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.68108514
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65398917
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20697831
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.20126009
7EZH2_22144423_ChIP-Seq_EOC_Human3.06139047
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.99479375
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77568853
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57641811
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44191562
12VDR_22108803_ChIP-Seq_LS180_Human2.18294507
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87591773
14STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79301296
15GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.73878640
16LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67964867
17RUNX_20019798_ChIP-Seq_JUKART_Human1.62228992
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61852228
19IRF8_27001747_Chip-Seq_BMDM_Mouse1.53089118
20MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52982683
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52928960
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50840679
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49492420
24IGF1R_20145208_ChIP-Seq_DFB_Human1.48586703
25MYB_26560356_Chip-Seq_TH2_Human1.47075749
26STAT1_20625510_ChIP-Seq_HELA_Human1.46552814
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43002903
28TP53_22573176_ChIP-Seq_HFKS_Human1.42643841
29PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38517389
30BCL6_27268052_Chip-Seq_Bcells_Human1.38279500
31TAF2_19829295_ChIP-Seq_ESCs_Human1.35279913
32HTT_18923047_ChIP-ChIP_STHdh_Human1.34773068
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34089583
34GATA3_26560356_Chip-Seq_TH2_Human1.33805748
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32028219
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30979633
37GATA3_27048872_Chip-Seq_THYMUS_Human1.30524169
38IRF1_19129219_ChIP-ChIP_H3396_Human1.30512095
39NANOG_20526341_ChIP-Seq_ESCs_Human1.28750829
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21626782
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.20229199
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19697674
43AR_20517297_ChIP-Seq_VCAP_Human1.19176493
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17340443
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17319499
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17066933
47SPI1_23547873_ChIP-Seq_NB4_Human1.11617833
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10550785
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10187290
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09221577
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07861160
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.07738942
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07009628
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.06860552
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06445486
56NANOG_19829295_ChIP-Seq_ESCs_Human1.04058978
57SOX2_19829295_ChIP-Seq_ESCs_Human1.04058978
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03781974
59MYC_19829295_ChIP-Seq_ESCs_Human1.02144759
60P300_27268052_Chip-Seq_Bcells_Human1.02121195
61FOXH1_21741376_ChIP-Seq_ESCs_Human1.01152435
62CTCF_20526341_ChIP-Seq_ESCs_Human1.00751317
63PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99369666
64UTX_26944678_Chip-Seq_JUKART_Human0.99326383
65BCOR_27268052_Chip-Seq_Bcells_Human0.98445326
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98314563
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97662479
68ZNF274_21170338_ChIP-Seq_K562_Hela0.96888009
69RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95634265
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95103737
71OCT4_20526341_ChIP-Seq_ESCs_Human0.92457425
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92234901
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91360865
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.90932266
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89879342
76NCOR_22424771_ChIP-Seq_293T_Human0.89864623
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.89638287
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89638287
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.89431379
80SPI1_23127762_ChIP-Seq_K562_Human0.88969951
81ERG_20517297_ChIP-Seq_VCAP_Human0.87970308
82SPI1_20517297_ChIP-Seq_HL60_Human0.86709751
83ERA_21632823_ChIP-Seq_H3396_Human0.86682916
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.85429298
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.85019535
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.84820401
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84812262
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84623183
89MYB_26560356_Chip-Seq_TH1_Human0.83572957
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.82897067
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82244066
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82097798
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81001957
94SA1_27219007_Chip-Seq_Bcells_Human0.80641449
95SOX2_21211035_ChIP-Seq_LN229_Human0.80535772
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78420333
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78208638
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77767997
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77738842
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77630913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.32680823
2MP0001835_abnormal_antigen_presentation3.12083191
3MP0003806_abnormal_nucleotide_metabolis3.11282444
4MP0002148_abnormal_hypersensitivity_rea3.09879496
5MP0003724_increased_susceptibility_to3.03413426
6MP0009785_altered_susceptibility_to2.89833259
7MP0005464_abnormal_platelet_physiology2.59704993
8MP0006082_CNS_inflammation2.50597865
9MP0005000_abnormal_immune_tolerance2.49068765
10MP0009764_decreased_sensitivity_to2.38589313
11MP0001800_abnormal_humoral_immune2.13432116
12MP0002723_abnormal_immune_serum2.08184586
13MP0005387_immune_system_phenotype2.05229402
14MP0001790_abnormal_immune_system2.05229402
15MP0005025_abnormal_response_to2.05060656
16MP0009333_abnormal_splenocyte_physiolog2.00571913
17MP0003436_decreased_susceptibility_to2.00237232
18MP0005360_urolithiasis1.97987793
19MP0002452_abnormal_antigen_presenting1.86979905
20MP0005167_abnormal_blood-brain_barrier1.86202068
21MP0002420_abnormal_adaptive_immunity1.78541943
22MP0001819_abnormal_immune_cell1.75876991
23MP0010155_abnormal_intestine_physiology1.70096720
24MP0002419_abnormal_innate_immunity1.69079814
25MP0002139_abnormal_hepatobiliary_system1.65740831
26MP0005646_abnormal_pituitary_gland1.64518396
27MP0001845_abnormal_inflammatory_respons1.63459734
28MP0003646_muscle_fatigue1.60379349
29MP0003303_peritoneal_inflammation1.56307291
30MP0005410_abnormal_fertilization1.54184762
31MP0000343_altered_response_to1.53924718
32MP0002138_abnormal_hepatobiliary_system1.52505158
33MP0000372_irregular_coat_pigmentation1.45205309
34MP0008004_abnormal_stomach_pH1.37779341
35MP0003183_abnormal_peptide_metabolism1.37013905
36MP0000685_abnormal_immune_system1.36811672
37MP0003866_abnormal_defecation1.35583011
38MP0003075_altered_response_to1.34643425
39MP0005645_abnormal_hypothalamus_physiol1.34321399
40MP0006276_abnormal_autonomic_nervous1.34039466
41MP0004147_increased_porphyrin_level1.33877710
42MP0008872_abnormal_physiological_respon1.28052753
43MP0008469_abnormal_protein_level1.27516260
44MP0001919_abnormal_reproductive_system1.26921441
45MP0002837_dystrophic_cardiac_calcinosis1.24828500
46MP0001873_stomach_inflammation1.24420400
47MP0001533_abnormal_skeleton_physiology1.24084742
48MP0000716_abnormal_immune_system1.23223418
49MP0009765_abnormal_xenobiotic_induced1.21284939
50MP0003195_calcinosis1.19569448
51MP0002405_respiratory_system_inflammati1.18201811
52MP0009763_increased_sensitivity_to1.16672190
53MP0001542_abnormal_bone_strength1.16535406
54MP0001905_abnormal_dopamine_level1.14781693
55MP0004510_myositis1.14179386
56MP0001968_abnormal_touch/_nociception1.11735011
57MP0000230_abnormal_systemic_arterial1.10999287
58MP0002398_abnormal_bone_marrow1.09964922
59MP0003763_abnormal_thymus_physiology1.09461587
60MP0008875_abnormal_xenobiotic_pharmacok1.08285256
61MP0002102_abnormal_ear_morphology1.07521168
62MP0009840_abnormal_foam_cell1.03848096
63MP0003186_abnormal_redox_activity1.03608575
64MP0004142_abnormal_muscle_tone0.99217197
65MP0005551_abnormal_eye_electrophysiolog0.99168479
66MP0005636_abnormal_mineral_homeostasis0.98935053
67MP0005166_decreased_susceptibility_to0.98662972
68MP0002429_abnormal_blood_cell0.97921614
69MP0005084_abnormal_gallbladder_morpholo0.97772341
70MP0002876_abnormal_thyroid_physiology0.97007824
71MP0001970_abnormal_pain_threshold0.96776706
72MP0009643_abnormal_urine_homeostasis0.96552553
73MP0002733_abnormal_thermal_nociception0.96304124
74MP0000465_gastrointestinal_hemorrhage0.96244577
75MP0001765_abnormal_ion_homeostasis0.96096180
76MP0006072_abnormal_retinal_apoptosis0.95836394
77MP0002653_abnormal_ependyma_morphology0.95511203
78MP0001663_abnormal_digestive_system0.94210062
79MP0002736_abnormal_nociception_after0.92772421
80MP0002277_abnormal_respiratory_mucosa0.91732062
81MP0002332_abnormal_exercise_endurance0.91128006
82MP0001756_abnormal_urination0.89862113
83MP0002933_joint_inflammation0.88188098
84MP0003638_abnormal_response/metabolism_0.86041855
85MP0000689_abnormal_spleen_morphology0.85364072
86MP0005389_reproductive_system_phenotype0.84314746
87MP0005310_abnormal_salivary_gland0.84033666
88MP0004947_skin_inflammation0.81417846
89MP0005451_abnormal_body_composition0.80106940
90MP0003878_abnormal_ear_physiology0.79332186
91MP0005377_hearing/vestibular/ear_phenot0.79332186
92MP0005332_abnormal_amino_acid0.76484765
93MP0002095_abnormal_skin_pigmentation0.75930810
94MP0002136_abnormal_kidney_physiology0.75890537
95MP0008995_early_reproductive_senescence0.73133862
96MP0005058_abnormal_lysosome_morphology0.72887634
97MP0002722_abnormal_immune_system0.72156492
98MP0003011_delayed_dark_adaptation0.72035753
99MP0003880_abnormal_central_pattern0.71175691
100MP0005253_abnormal_eye_physiology0.70795795

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)3.96565752
2Decreased circulating renin level (HP:0003351)3.92271512
3Stomatitis (HP:0010280)3.50601351
4Acute necrotizing encephalopathy (HP:0006965)3.49240111
5Decreased electroretinogram (ERG) amplitude (HP:0000654)3.37268681
6Petechiae (HP:0000967)3.36668629
7Abnormal mitochondria in muscle tissue (HP:0008316)3.28697309
8T lymphocytopenia (HP:0005403)3.28446139
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21578913
10Abnormality of T cell number (HP:0011839)3.19836970
11Hypoproteinemia (HP:0003075)3.17525034
12Decreased central vision (HP:0007663)3.14600851
13Polydipsia (HP:0001959)3.10841508
14Abnormal drinking behavior (HP:0030082)3.10841508
15IgG deficiency (HP:0004315)3.07881117
16Generalized aminoaciduria (HP:0002909)3.07186380
17Increased IgM level (HP:0003496)3.06011246
18Purpura (HP:0000979)3.05456535
19Mitochondrial inheritance (HP:0001427)3.02757387
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.01419992
21Abnormality of glycolipid metabolism (HP:0010969)3.01419992
22Abnormality of liposaccharide metabolism (HP:0010968)3.01419992
23Abolished electroretinogram (ERG) (HP:0000550)2.95051993
24Abnormality of macrophages (HP:0004311)2.91628221
253-Methylglutaconic aciduria (HP:0003535)2.90901943
26Acute encephalopathy (HP:0006846)2.88292600
27Abnormality of the prostate (HP:0008775)2.82621670
28Progressive macrocephaly (HP:0004481)2.77412559
29Obstructive lung disease (HP:0006536)2.73315169
30Chronic obstructive pulmonary disease (HP:0006510)2.73315169
31Aplastic anemia (HP:0001915)2.68037152
32Congenital stationary night blindness (HP:0007642)2.64728691
33Prolonged bleeding time (HP:0003010)2.62149283
34Epistaxis (HP:0000421)2.55473886
35Hepatocellular necrosis (HP:0001404)2.52806922
36Agitation (HP:0000713)2.51752054
37Nausea (HP:0002018)2.48699663
38Increased CSF lactate (HP:0002490)2.48495841
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44396796
40Abnormality of alanine metabolism (HP:0010916)2.44396796
41Hyperalaninemia (HP:0003348)2.44396796
42Hepatic necrosis (HP:0002605)2.43841583
43Increased intramyocellular lipid droplets (HP:0012240)2.42757240
44Polyuria (HP:0000103)2.39834727
45Autoimmune hemolytic anemia (HP:0001890)2.39232820
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39204673
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39204673
48Vacuolated lymphocytes (HP:0001922)2.38488893
49Autoimmune thrombocytopenia (HP:0001973)2.35853810
50Abnormal rod and cone electroretinograms (HP:0008323)2.35622801
51Increased serum ferritin (HP:0003281)2.32503717
52Hemoptysis (HP:0002105)2.32379132
53Renal Fanconi syndrome (HP:0001994)2.27933611
54Chronic diarrhea (HP:0002028)2.27600688
55Tongue fasciculations (HP:0001308)2.26090056
56Abnormality of B cell number (HP:0010975)2.24575085
57Spontaneous hematomas (HP:0007420)2.24234640
58Cerebral edema (HP:0002181)2.23885699
59Gangrene (HP:0100758)2.22783090
60Encephalitis (HP:0002383)2.19332363
61Gastrointestinal infarctions (HP:0005244)2.18726671
62Hyperlipoproteinemia (HP:0010980)2.17254534
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16074602
64Optic disc pallor (HP:0000543)2.15940523
65Myositis (HP:0100614)2.14808429
66Abnormality of renin-angiotensin system (HP:0000847)2.14334860
67Vasculitis (HP:0002633)2.11806242
68Constricted visual fields (HP:0001133)2.11677748
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11536294
70Abnormality of midbrain morphology (HP:0002418)2.08959141
71Molar tooth sign on MRI (HP:0002419)2.08959141
72Leukocytosis (HP:0001974)2.07912414
73Abnormal urine output (HP:0012590)2.07499054
74Abnormality of iron homeostasis (HP:0011031)2.06838641
75Gingival bleeding (HP:0000225)2.04322951
76Increased muscle lipid content (HP:0009058)2.03391899
77Optic neuritis (HP:0100653)2.00877706
78Retrobulbar optic neuritis (HP:0100654)2.00877706
79Chest pain (HP:0100749)2.00502761
80Attenuation of retinal blood vessels (HP:0007843)1.99096714
81Muscle fibrillation (HP:0010546)1.98793725
82Pulmonary embolism (HP:0002204)1.98423277
83Abnormality of transition element cation homeostasis (HP:0011030)1.96480625
84Abnormality of T cells (HP:0002843)1.96390477
85Joint swelling (HP:0001386)1.95016263
86B lymphocytopenia (HP:0010976)1.91612432
87Abnormality of eosinophils (HP:0001879)1.91458922
88Abnormality of renal excretion (HP:0011036)1.87801801
89Anorexia (HP:0002039)1.85328946
90Orchitis (HP:0100796)1.84659231
91Exertional dyspnea (HP:0002875)1.84100949
92Pulmonary infiltrates (HP:0002113)1.83929295
93Lactic acidosis (HP:0003128)1.83709828
94Congenital sensorineural hearing impairment (HP:0008527)1.82732101
95Hyponatremia (HP:0002902)1.82338783
96Meningitis (HP:0001287)1.82241555
97Menorrhagia (HP:0000132)1.81926173
98Increased serum lactate (HP:0002151)1.78325481
99Episodic fever (HP:0001954)1.78267005
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.78194892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.79016287
2TESK23.07083049
3BLK2.98149261
4KDR2.93744089
5TAOK32.78639748
6MAP3K112.49293953
7GRK72.34268733
8BCKDK2.19949951
9ADRBK22.19561330
10TLK12.10100023
11MAP4K11.92280468
12SYK1.91231190
13MYLK1.86758683
14GRK11.79876981
15MATK1.70373041
16ITK1.64519765
17FES1.62870430
18LIMK11.60342949
19MAP3K121.57113698
20EPHB21.56329022
21IKBKB1.52893433
22CDK191.42937644
23WNK41.42903118
24CSK1.41893164
25ZAK1.41406339
26TEC1.38540286
27MAP2K71.38412610
28MAP4K21.33589360
29PIM21.31882480
30BMPR21.31866901
31BTK1.29830503
32TNK21.25056960
33TESK11.24334799
34MST41.20597028
35LYN1.19662100
36NUAK11.13697985
37GRK61.12223157
38JAK31.08829169
39CSF1R1.06683763
40RIPK41.05409513
41GRK51.05305525
42TBK11.03971293
43TGFBR21.02012205
44DAPK21.01712688
45IRAK30.93657018
46IKBKE0.93482221
47TIE10.92339540
48PRKCQ0.91285392
49PINK10.90539296
50ACVR1B0.89568265
51LCK0.88722678
52MAPKAPK30.86046873
53MOS0.85215136
54KIT0.80351781
55ADRBK10.77877740
56MAP3K30.76435851
57TAOK20.72772713
58FGR0.71720740
59BMPR1B0.71228296
60TYRO30.71048122
61OXSR10.69738001
62ZAP700.67182781
63ARAF0.66847418
64DAPK30.65525909
65PTK2B0.61348894
66DYRK20.61149470
67DAPK10.60361071
68MAP3K50.58027312
69MARK30.55888613
70TAOK10.55758896
71RPS6KA50.54433240
72CSNK1G30.53993689
73MUSK0.53948244
74FYN0.53110077
75IRAK40.52860143
76PAK10.52642964
77PRKCA0.52488576
78STK160.52447419
79ABL20.52312337
80PRKACA0.51513150
81NME20.50941531
82PIK3CA0.50940137
83INSRR0.49015024
84CAMK2A0.48045043
85DDR20.46905708
86JAK20.46757074
87PRKCD0.45999788
88CAMKK20.45663871
89MAP3K40.44099036
90CAMK2D0.41858355
91INSR0.41242184
92IGF1R0.40522117
93PIM10.39739063
94ERBB20.38843076
95FRK0.37935169
96PRKCE0.37858965
97OBSCN0.37759664
98PRKACG0.37068354
99SCYL20.35841447
100BMX0.35362702

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.73012849
2Allograft rejection_Homo sapiens_hsa053303.53773117
3Autoimmune thyroid disease_Homo sapiens_hsa053203.48560838
4Asthma_Homo sapiens_hsa053103.21198193
5Primary immunodeficiency_Homo sapiens_hsa053402.90877401
6Rheumatoid arthritis_Homo sapiens_hsa053232.83576013
7Oxidative phosphorylation_Homo sapiens_hsa001902.78060230
8Type I diabetes mellitus_Homo sapiens_hsa049402.76602708
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.63283383
10Antigen processing and presentation_Homo sapiens_hsa046122.35635608
11Hematopoietic cell lineage_Homo sapiens_hsa046402.26967748
12Parkinsons disease_Homo sapiens_hsa050122.20668552
13Staphylococcus aureus infection_Homo sapiens_hsa051502.20312628
14Proteasome_Homo sapiens_hsa030501.95479602
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88818762
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84361779
17Collecting duct acid secretion_Homo sapiens_hsa049661.83724894
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63867706
19Viral myocarditis_Homo sapiens_hsa054161.55209559
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47325840
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43894930
22Alzheimers disease_Homo sapiens_hsa050101.36141651
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33738990
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33636511
25Phototransduction_Homo sapiens_hsa047441.33355393
26Cardiac muscle contraction_Homo sapiens_hsa042601.32196035
27Sulfur metabolism_Homo sapiens_hsa009201.31357941
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28754543
29Malaria_Homo sapiens_hsa051441.24876599
30Leishmaniasis_Homo sapiens_hsa051401.23629232
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18243852
32Linoleic acid metabolism_Homo sapiens_hsa005911.18132881
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.15633665
34Salmonella infection_Homo sapiens_hsa051321.15514216
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15109666
36Phagosome_Homo sapiens_hsa041451.10498764
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10139658
38T cell receptor signaling pathway_Homo sapiens_hsa046601.08441463
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06001358
40Huntingtons disease_Homo sapiens_hsa050161.03117366
41Protein export_Homo sapiens_hsa030600.97752904
42Arachidonic acid metabolism_Homo sapiens_hsa005900.93345302
43Systemic lupus erythematosus_Homo sapiens_hsa053220.92348698
44Regulation of autophagy_Homo sapiens_hsa041400.92074312
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89574989
46Chemokine signaling pathway_Homo sapiens_hsa040620.88315530
47Nitrogen metabolism_Homo sapiens_hsa009100.86949398
48Caffeine metabolism_Homo sapiens_hsa002320.80652637
49Lysosome_Homo sapiens_hsa041420.80296899
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80097053
51Tuberculosis_Homo sapiens_hsa051520.79513959
52Peroxisome_Homo sapiens_hsa041460.78942603
53Platelet activation_Homo sapiens_hsa046110.78352863
54Chemical carcinogenesis_Homo sapiens_hsa052040.77104523
55Morphine addiction_Homo sapiens_hsa050320.75881135
56Osteoclast differentiation_Homo sapiens_hsa043800.75495319
57Olfactory transduction_Homo sapiens_hsa047400.74661778
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71373096
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.67990767
60Shigellosis_Homo sapiens_hsa051310.65895758
61Pertussis_Homo sapiens_hsa051330.65580922
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64766065
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.64761448
64Ether lipid metabolism_Homo sapiens_hsa005650.63736982
65Ribosome_Homo sapiens_hsa030100.62337963
66Mineral absorption_Homo sapiens_hsa049780.57640403
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.56129886
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53977879
69GABAergic synapse_Homo sapiens_hsa047270.53660110
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53030219
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51931192
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51802399
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50602700
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50162034
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48909439
76Legionellosis_Homo sapiens_hsa051340.47633720
77Measles_Homo sapiens_hsa051620.47594591
78Vibrio cholerae infection_Homo sapiens_hsa051100.47381401
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46889109
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43036925
81TNF signaling pathway_Homo sapiens_hsa046680.42912918
82Retinol metabolism_Homo sapiens_hsa008300.41772769
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41633746
84Influenza A_Homo sapiens_hsa051640.41623179
85Herpes simplex infection_Homo sapiens_hsa051680.40759035
86Fat digestion and absorption_Homo sapiens_hsa049750.40397742
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.39361902
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39160071
89African trypanosomiasis_Homo sapiens_hsa051430.39110967
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37271489
91Tryptophan metabolism_Homo sapiens_hsa003800.36903627
92Serotonergic synapse_Homo sapiens_hsa047260.36058710
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.35422254
94Ovarian steroidogenesis_Homo sapiens_hsa049130.32098816
95RNA polymerase_Homo sapiens_hsa030200.30526120
96PPAR signaling pathway_Homo sapiens_hsa033200.27755493
97Synaptic vesicle cycle_Homo sapiens_hsa047210.27559258
98Butanoate metabolism_Homo sapiens_hsa006500.26451287
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25235506
100Metabolic pathways_Homo sapiens_hsa011000.23964913

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