FTH1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.91881800
2Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22002031
3immunoglobulin mediated immune response (GO:0016064)4.11380283
4neutrophil activation involved in immune response (GO:0002283)3.97895592
5actin nucleation (GO:0045010)3.96368122
6platelet dense granule organization (GO:0060155)3.74654584
7negative regulation of mast cell activation (GO:0033004)3.73123557
8cytidine metabolic process (GO:0046087)3.64931893
9cytidine catabolic process (GO:0006216)3.64931893
10cytidine deamination (GO:0009972)3.64931893
11DNA deamination (GO:0045006)3.64492427
12sequestering of actin monomers (GO:0042989)3.55494933
13eosinophil chemotaxis (GO:0048245)3.44686325
14ATP synthesis coupled proton transport (GO:0015986)3.36546440
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36546440
16autophagic vacuole fusion (GO:0000046)3.32812363
17neutrophil activation (GO:0042119)3.27630453
18B cell mediated immunity (GO:0019724)3.16601663
19granulocyte activation (GO:0036230)3.12662247
20eosinophil migration (GO:0072677)3.09353938
21pyrimidine ribonucleoside catabolic process (GO:0046133)3.07884603
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03453331
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99496719
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99146007
25positive regulation of monocyte chemotaxis (GO:0090026)2.97087392
26interferon-gamma-mediated signaling pathway (GO:0060333)2.94958718
27T cell costimulation (GO:0031295)2.86847070
28response to interferon-beta (GO:0035456)2.84858261
29negative regulation of heart rate (GO:0010459)2.84776405
30lymphocyte costimulation (GO:0031294)2.84180845
31positive regulation of antigen processing and presentation (GO:0002579)2.83411695
32organelle membrane fusion (GO:0090174)2.76424785
33xenobiotic catabolic process (GO:0042178)2.74492309
34electron transport chain (GO:0022900)2.73844638
35respiratory electron transport chain (GO:0022904)2.73100469
36hydrogen ion transmembrane transport (GO:1902600)2.72168143
37proton transport (GO:0015992)2.68532020
38regulation of chronic inflammatory response (GO:0002676)2.67522978
39mature B cell differentiation involved in immune response (GO:0002313)2.65052106
40hydrogen transport (GO:0006818)2.64229775
41negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.64180945
42mast cell activation (GO:0045576)2.59400627
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58797383
44thrombin receptor signaling pathway (GO:0070493)2.58279027
45positive regulation of defense response to virus by host (GO:0002230)2.58227040
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57084419
47regulation of antigen processing and presentation (GO:0002577)2.55111850
48amine catabolic process (GO:0009310)2.54142769
49cellular biogenic amine catabolic process (GO:0042402)2.54142769
50regulation of mast cell activation (GO:0033003)2.53938969
51phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53832643
52regulation of inflammatory response to antigenic stimulus (GO:0002861)2.50225876
53positive regulation of respiratory burst (GO:0060267)2.49623869
54negative regulation of nitric-oxide synthase activity (GO:0051001)2.48170523
55cellular response to interferon-gamma (GO:0071346)2.47858125
56phagosome maturation (GO:0090382)2.47494812
57cellular response to interferon-beta (GO:0035458)2.47401183
58positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46709174
59positive regulation of interleukin-1 beta secretion (GO:0050718)2.45299917
60positive regulation of mast cell activation (GO:0033005)2.44447586
61antigen processing and presentation via MHC class Ib (GO:0002475)2.44243930
62positive regulation of protein homodimerization activity (GO:0090073)2.42483936
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.42001304
64adaptation of signaling pathway (GO:0023058)2.40774694
65negative regulation of monooxygenase activity (GO:0032769)2.40166198
66response to interferon-gamma (GO:0034341)2.39573042
67killing of cells of other organism (GO:0031640)2.38455706
68disruption of cells of other organism (GO:0044364)2.38455706
69arginine metabolic process (GO:0006525)2.37989879
70regulation of T cell mediated cytotoxicity (GO:0001914)2.36392460
71L-fucose catabolic process (GO:0042355)2.36361297
72fucose catabolic process (GO:0019317)2.36361297
73L-fucose metabolic process (GO:0042354)2.36361297
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.34875300
75negative regulation of T cell apoptotic process (GO:0070233)2.31883246
76positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.31360555
77fusion of sperm to egg plasma membrane (GO:0007342)2.30656061
78pyrimidine nucleoside catabolic process (GO:0046135)2.29115108
79positive regulation of interleukin-1 secretion (GO:0050716)2.28567933
80regulation of guanylate cyclase activity (GO:0031282)2.28528915
81regulation of interleukin-1 beta secretion (GO:0050706)2.28373737
82regulation of cellular extravasation (GO:0002691)2.26089653
83behavioral response to nicotine (GO:0035095)2.24737829
84sulfation (GO:0051923)2.24712560
85ATP hydrolysis coupled proton transport (GO:0015991)2.24255106
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.24255106
87leukocyte degranulation (GO:0043299)2.24195807
88regulation of mononuclear cell migration (GO:0071675)2.24065787
89positive regulation of prostaglandin secretion (GO:0032308)2.23925369
90regulation of monocyte chemotaxis (GO:0090025)2.23806204
91positive regulation of interleukin-17 production (GO:0032740)2.23535788
92negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.23030952
93positive thymic T cell selection (GO:0045059)2.22857402
94antigen processing and presentation of endogenous antigen (GO:0019883)2.22120068
95cellular response to zinc ion (GO:0071294)2.21651112
96positive regulation of T cell apoptotic process (GO:0070234)2.20587310
97mitochondrial calcium ion transport (GO:0006851)2.16168871
98negative regulation of calcium ion transport into cytosol (GO:0010523)2.16089601
99glutathione biosynthetic process (GO:0006750)2.15188952
100leukotriene biosynthetic process (GO:0019370)2.15078409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.69097469
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33837751
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.90498114
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61625507
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.80371888
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61110074
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55371391
8EZH2_22144423_ChIP-Seq_EOC_Human2.52017000
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.47756804
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42826619
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00236983
12LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92817419
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91511687
14ZNF274_21170338_ChIP-Seq_K562_Hela1.77597916
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.73168522
16GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.70473555
17VDR_22108803_ChIP-Seq_LS180_Human1.69734295
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68088426
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64930095
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63056593
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.61946349
22TAF2_19829295_ChIP-Seq_ESCs_Human1.55839277
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55206271
24BCL6_27268052_Chip-Seq_Bcells_Human1.54425106
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52465439
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51863244
27GATA3_26560356_Chip-Seq_TH2_Human1.51764603
28STAT1_20625510_ChIP-Seq_HELA_Human1.50515799
29NANOG_20526341_ChIP-Seq_ESCs_Human1.49294104
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47310893
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47300777
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44166505
33IGF1R_20145208_ChIP-Seq_DFB_Human1.42584672
34PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39774215
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37220634
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37202260
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36432703
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36298748
39AR_20517297_ChIP-Seq_VCAP_Human1.33625262
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.33236020
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33236020
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32696972
43TP53_22573176_ChIP-Seq_HFKS_Human1.32351957
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30245072
45MYB_26560356_Chip-Seq_TH2_Human1.27762132
46SPI1_23547873_ChIP-Seq_NB4_Human1.27358989
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26295638
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25348411
49MYC_19829295_ChIP-Seq_ESCs_Human1.24048869
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22313140
51IRF1_19129219_ChIP-ChIP_H3396_Human1.21536529
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.21512275
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20305742
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19330120
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18169334
56FOXH1_21741376_ChIP-Seq_ESCs_Human1.17711422
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17056900
58EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16566361
59GATA3_27048872_Chip-Seq_THYMUS_Human1.15025233
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.15023837
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.14946923
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14710878
63RUNX_20019798_ChIP-Seq_JUKART_Human1.14226363
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13446140
65P300_27268052_Chip-Seq_Bcells_Human1.12691154
66SOX2_19829295_ChIP-Seq_ESCs_Human1.12535797
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12535797
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12409958
69ERA_21632823_ChIP-Seq_H3396_Human1.12263668
70NCOR_22424771_ChIP-Seq_293T_Human1.11293315
71ERG_20517297_ChIP-Seq_VCAP_Human1.08243238
72SOX2_21211035_ChIP-Seq_LN229_Human1.04684149
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.04583610
74CTCF_20526341_ChIP-Seq_ESCs_Human1.03972326
75BCOR_27268052_Chip-Seq_Bcells_Human1.03526367
76SPI1_23127762_ChIP-Seq_K562_Human1.02652583
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00754464
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00605588
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00599748
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00365774
81RAC3_21632823_ChIP-Seq_H3396_Human0.98296124
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98179719
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.98026806
84SA1_27219007_Chip-Seq_Bcells_Human0.97891760
85HTT_18923047_ChIP-ChIP_STHdh_Human0.97422920
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96824816
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96099797
88E2F1_20622854_ChIP-Seq_HELA_Human0.95467206
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94428178
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93312539
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92771451
92VDR_23849224_ChIP-Seq_CD4+_Human0.91731804
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91326078
94SCL_19346495_ChIP-Seq_HPC-7_Human0.91298621
95CIITA_25753668_ChIP-Seq_RAJI_Human0.90919171
96OCT4_20526341_ChIP-Seq_ESCs_Human0.89697875
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89259280
98EGR1_19032775_ChIP-ChIP_M12_Human0.88380643
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87681108
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85663402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.60321787
2MP0003724_increased_susceptibility_to3.30241261
3MP0001835_abnormal_antigen_presentation3.20319651
4MP0002148_abnormal_hypersensitivity_rea2.90008593
5MP0005464_abnormal_platelet_physiology2.85706481
6MP0009764_decreased_sensitivity_to2.68926188
7MP0009785_altered_susceptibility_to2.60150899
8MP0004147_increased_porphyrin_level2.53365040
9MP0003806_abnormal_nucleotide_metabolis2.47799908
10MP0005000_abnormal_immune_tolerance2.21146012
11MP0003646_muscle_fatigue2.11018890
12MP0005167_abnormal_blood-brain_barrier2.06276586
13MP0002139_abnormal_hepatobiliary_system2.04155175
14MP0010155_abnormal_intestine_physiology2.02771852
15MP0001800_abnormal_humoral_immune1.97144524
16MP0003436_decreased_susceptibility_to1.96831614
17MP0000685_abnormal_immune_system1.95543717
18MP0003303_peritoneal_inflammation1.94078739
19MP0005387_immune_system_phenotype1.91545841
20MP0001790_abnormal_immune_system1.91545841
21MP0002138_abnormal_hepatobiliary_system1.91381808
22MP0005084_abnormal_gallbladder_morpholo1.89401865
23MP0005025_abnormal_response_to1.87801919
24MP0002723_abnormal_immune_serum1.83540939
25MP0006082_CNS_inflammation1.82314412
26MP0005360_urolithiasis1.76656301
27MP0005058_abnormal_lysosome_morphology1.71590427
28MP0002452_abnormal_antigen_presenting1.71165110
29MP0009840_abnormal_foam_cell1.67579772
30MP0000343_altered_response_to1.64481525
31MP0001845_abnormal_inflammatory_respons1.58838238
32MP0009379_abnormal_foot_pigmentation1.55879159
33MP0001819_abnormal_immune_cell1.54428490
34MP0002420_abnormal_adaptive_immunity1.53775942
35MP0002837_dystrophic_cardiac_calcinosis1.53273763
36MP0002419_abnormal_innate_immunity1.53016225
37MP0008872_abnormal_physiological_respon1.52365909
38MP0008875_abnormal_xenobiotic_pharmacok1.49815244
39MP0003075_altered_response_to1.46433771
40MP0000372_irregular_coat_pigmentation1.43157094
41MP0009333_abnormal_splenocyte_physiolog1.42458288
42MP0002102_abnormal_ear_morphology1.41060390
43MP0008004_abnormal_stomach_pH1.40455362
44MP0005083_abnormal_biliary_tract1.36514420
45MP0001905_abnormal_dopamine_level1.36337362
46MP0001533_abnormal_skeleton_physiology1.35880205
47MP0003186_abnormal_redox_activity1.32388210
48MP0003866_abnormal_defecation1.29931153
49MP0005645_abnormal_hypothalamus_physiol1.26587515
50MP0005075_abnormal_melanosome_morpholog1.20779406
51MP0005166_decreased_susceptibility_to1.20388912
52MP0002733_abnormal_thermal_nociception1.20141827
53MP0008469_abnormal_protein_level1.18677798
54MP0003879_abnormal_hair_cell1.18415772
55MP0002876_abnormal_thyroid_physiology1.16062186
56MP0004142_abnormal_muscle_tone1.15148548
57MP0003195_calcinosis1.15133597
58MP0003638_abnormal_response/metabolism_1.14127434
59MP0001968_abnormal_touch/_nociception1.13139360
60MP0001663_abnormal_digestive_system1.12909637
61MP0001970_abnormal_pain_threshold1.09565832
62MP0005410_abnormal_fertilization1.08327246
63MP0000230_abnormal_systemic_arterial1.06116288
64MP0005365_abnormal_bile_salt1.05449881
65MP0000716_abnormal_immune_system1.04772545
66MP0005551_abnormal_eye_electrophysiolog1.03710374
67MP0001873_stomach_inflammation1.01463581
68MP0005174_abnormal_tail_pigmentation1.01062884
69MP0006036_abnormal_mitochondrial_physio0.98312045
70MP0001501_abnormal_sleep_pattern0.97781920
71MP0005085_abnormal_gallbladder_physiolo0.97677884
72MP0004043_abnormal_pH_regulation0.97264857
73MP0003011_delayed_dark_adaptation0.97168531
74MP0001986_abnormal_taste_sensitivity0.96170540
75MP0001542_abnormal_bone_strength0.95625408
76MP0004947_skin_inflammation0.95502202
77MP0002736_abnormal_nociception_after0.94421856
78MP0009643_abnormal_urine_homeostasis0.91617342
79MP0002653_abnormal_ependyma_morphology0.91502579
80MP0009763_increased_sensitivity_to0.90787596
81MP0004019_abnormal_vitamin_homeostasis0.88239791
82MP0002405_respiratory_system_inflammati0.87687088
83MP0001919_abnormal_reproductive_system0.85618797
84MP0009765_abnormal_xenobiotic_induced0.84548542
85MP0002398_abnormal_bone_marrow0.84463831
86MP0002429_abnormal_blood_cell0.83046119
87MP0005332_abnormal_amino_acid0.81128562
88MP0001440_abnormal_grooming_behavior0.80358030
89MP0005636_abnormal_mineral_homeostasis0.80304997
90MP0000465_gastrointestinal_hemorrhage0.79648874
91MP0001664_abnormal_digestion0.79407190
92MP0000689_abnormal_spleen_morphology0.78692419
93MP0002277_abnormal_respiratory_mucosa0.77528173
94MP0005535_abnormal_body_temperature0.77379423
95MP0008775_abnormal_heart_ventricle0.76829736
96MP0009278_abnormal_bone_marrow0.75716318
97MP0002136_abnormal_kidney_physiology0.75072726
98MP0002272_abnormal_nervous_system0.73984184
99MP0000015_abnormal_ear_pigmentation0.73574107
100MP0006072_abnormal_retinal_apoptosis0.72954782

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.47998546
2Decreased central vision (HP:0007663)3.91179561
3Acute necrotizing encephalopathy (HP:0006965)3.60982515
4Abnormal mitochondria in muscle tissue (HP:0008316)3.52099612
5Mitochondrial inheritance (HP:0001427)3.30734213
6Petechiae (HP:0000967)3.24762810
7Increased IgM level (HP:0003496)3.19368568
8Stomatitis (HP:0010280)3.17135115
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.14842041
10Abnormality of glycolipid metabolism (HP:0010969)3.14804785
11Abnormality of liposaccharide metabolism (HP:0010968)3.14804785
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.14804785
13Acute encephalopathy (HP:0006846)3.13745102
14IgG deficiency (HP:0004315)3.12084915
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01366642
16Progressive macrocephaly (HP:0004481)3.00156010
17Hepatic necrosis (HP:0002605)2.99665982
18Increased intramyocellular lipid droplets (HP:0012240)2.98096222
19Hepatocellular necrosis (HP:0001404)2.93411199
20Increased CSF lactate (HP:0002490)2.85436257
21Congenital stationary night blindness (HP:0007642)2.85358944
22Generalized aminoaciduria (HP:0002909)2.73907761
23Abolished electroretinogram (ERG) (HP:0000550)2.72329420
24Purpura (HP:0000979)2.70734578
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66734726
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66734726
27Nausea (HP:0002018)2.65306791
28Hyperalaninemia (HP:0003348)2.63818934
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63818934
30Abnormality of alanine metabolism (HP:0010916)2.63818934
31Increased muscle lipid content (HP:0009058)2.63731288
32Renal Fanconi syndrome (HP:0001994)2.62818309
33Abnormality of B cell number (HP:0010975)2.59036525
343-Methylglutaconic aciduria (HP:0003535)2.57721214
35Autoimmune thrombocytopenia (HP:0001973)2.53257214
36Increased hepatocellular lipid droplets (HP:0006565)2.48582382
37Abnormal rod and cone electroretinograms (HP:0008323)2.46755948
38Lipid accumulation in hepatocytes (HP:0006561)2.43738470
39Glycosuria (HP:0003076)2.41632782
40Abnormality of urine glucose concentration (HP:0011016)2.41632782
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.39397916
42Chronic obstructive pulmonary disease (HP:0006510)2.38363106
43Obstructive lung disease (HP:0006536)2.38363106
44Exertional dyspnea (HP:0002875)2.36970371
45Prolonged bleeding time (HP:0003010)2.34203208
46Abnormality of magnesium homeostasis (HP:0004921)2.33952795
47Agitation (HP:0000713)2.31896495
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30773243
49Abnormality of the prostate (HP:0008775)2.30219639
50Vacuolated lymphocytes (HP:0001922)2.29058056
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27870609
52Cerebral edema (HP:0002181)2.26573529
53Molar tooth sign on MRI (HP:0002419)2.24411429
54Abnormality of midbrain morphology (HP:0002418)2.24411429
55Increased cerebral lipofuscin (HP:0011813)2.23918264
56Increased serum ferritin (HP:0003281)2.21088934
57Abnormality of macrophages (HP:0004311)2.20286338
58Abnormality of iron homeostasis (HP:0011031)2.17382327
59Abnormality of transition element cation homeostasis (HP:0011030)2.15999255
60Systemic lupus erythematosus (HP:0002725)2.15585507
61Lactic acidosis (HP:0003128)2.14019907
62Polyphagia (HP:0002591)2.13464592
63Increased serum lactate (HP:0002151)2.09193438
64Optic disc pallor (HP:0000543)2.07593115
65Epistaxis (HP:0000421)2.06634016
66Hypomagnesemia (HP:0002917)2.05751272
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04605674
68Methylmalonic aciduria (HP:0012120)2.03473030
69Lethargy (HP:0001254)2.01901232
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01245717
71Abnormality of T cell number (HP:0011839)1.98958001
72Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98232378
73Dicarboxylic aciduria (HP:0003215)1.98232378
74B lymphocytopenia (HP:0010976)1.97372194
75Vasculitis (HP:0002633)1.95912982
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95711729
77Myositis (HP:0100614)1.95708366
78Hypoproteinemia (HP:0003075)1.92273701
79Encephalitis (HP:0002383)1.89806668
80Pancreatic fibrosis (HP:0100732)1.86579536
81Hypergammaglobulinemia (HP:0010702)1.85964639
82Hydroxyprolinuria (HP:0003080)1.81469805
83Abnormality of proline metabolism (HP:0010907)1.81469805
84Clumsiness (HP:0002312)1.81325164
85Leukocytosis (HP:0001974)1.80230843
86Mutism (HP:0002300)1.80197279
87Abnormality of serum amino acid levels (HP:0003112)1.77252877
88Respiratory failure (HP:0002878)1.77051029
89T lymphocytopenia (HP:0005403)1.76390304
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.75774966
91Absent/shortened dynein arms (HP:0200106)1.75774966
92Renal cortical cysts (HP:0000803)1.74600385
93Attenuation of retinal blood vessels (HP:0007843)1.74454840
94Autoimmune hemolytic anemia (HP:0001890)1.73188113
95Abnormal respiratory epithelium morphology (HP:0012253)1.72467491
96Abnormal respiratory motile cilium morphology (HP:0005938)1.72467491
97Pulmonary infiltrates (HP:0002113)1.72464746
98Keratoconus (HP:0000563)1.70557792
99Increased corneal curvature (HP:0100692)1.70557792
100Pancreatic cysts (HP:0001737)1.70473489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.03708346
2TLK13.31573362
3TXK3.03343870
4ADRBK22.81918248
5KDR2.61398568
6MAP4K22.55111549
7PINK12.40337753
8BCKDK2.30619233
9GRK12.25492595
10MST41.94004957
11ZAK1.93126251
12TESK21.90157391
13TIE11.86442811
14MATK1.85597782
15MAP3K121.83618587
16MAP4K11.77625599
17IKBKB1.74129947
18RIPK41.72192370
19TEC1.69743861
20MYLK1.62358125
21ACVR1B1.57826780
22SYK1.54809051
23BMPR21.51666865
24GRK71.50150567
25MAPKAPK31.47382171
26KIT1.40604176
27TBK11.40458993
28BTK1.37884512
29GRK61.36076446
30EPHB21.31959224
31MAP3K111.27341680
32STK161.25528127
33FES1.18362803
34CDK191.13485311
35DAPK21.12530907
36PIM21.10963746
37CSF1R1.10772377
38ITK1.10165119
39LYN1.09602013
40IRAK31.09206035
41LIMK11.07046796
42WNK41.03907202
43ABL21.03618442
44MAPK131.01821866
45IKBKE1.00165955
46ZAP700.96898033
47NME20.96144074
48MAP3K140.91786156
49DYRK20.89717630
50NUAK10.88066352
51MAP2K70.84506032
52ADRBK10.82254789
53JAK30.77388953
54OXSR10.77247634
55LCK0.76048652
56CSK0.75571328
57MARK30.75236201
58PRKCQ0.72434191
59TRIM280.72299544
60PTK2B0.71836937
61GRK50.70342989
62RPS6KA50.70337359
63TRPM70.69764183
64DAPK10.69061057
65SIK30.68710334
66MAP2K20.67260134
67ILK0.67174499
68DAPK30.67050721
69FRK0.63958319
70PHKG10.63238355
71PHKG20.63238355
72CAMKK20.62004300
73PDK20.59492931
74ERBB30.58571824
75BLK0.57420528
76PIM10.57356774
77PRKCA0.54801759
78HCK0.54419320
79BMPR1B0.53545816
80ABL10.52639892
81TAOK20.51515543
82PRKG20.50291649
83TESK10.49471764
84MINK10.48349610
85MAP3K50.47240024
86TYK20.47217576
87CHUK0.45969845
88WNK30.45856779
89PRKCD0.45795458
90PIK3CA0.45509503
91PRKCG0.44606070
92PRKACA0.44281518
93PRKCE0.44090443
94PAK10.43857807
95DDR20.42158902
96BMX0.41967049
97CSNK1G30.39916029
98PRKACG0.39548875
99IGF1R0.39239973
100MAP3K40.37904585

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.77930813
2Allograft rejection_Homo sapiens_hsa053303.83444473
3Graft-versus-host disease_Homo sapiens_hsa053323.66320494
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.66263841
5Autoimmune thyroid disease_Homo sapiens_hsa053203.57518527
6Type I diabetes mellitus_Homo sapiens_hsa049403.21457516
7Rheumatoid arthritis_Homo sapiens_hsa053232.73909446
8Oxidative phosphorylation_Homo sapiens_hsa001902.66814559
9Staphylococcus aureus infection_Homo sapiens_hsa051502.50933969
10Antigen processing and presentation_Homo sapiens_hsa046122.21485316
11Parkinsons disease_Homo sapiens_hsa050122.05663906
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03518713
13Hematopoietic cell lineage_Homo sapiens_hsa046401.75538847
14Collecting duct acid secretion_Homo sapiens_hsa049661.74036809
15Sulfur metabolism_Homo sapiens_hsa009201.70082699
16Primary immunodeficiency_Homo sapiens_hsa053401.69295194
17Leishmaniasis_Homo sapiens_hsa051401.68297177
18Proteasome_Homo sapiens_hsa030501.67780715
19Viral myocarditis_Homo sapiens_hsa054161.67034482
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60664642
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58890532
22Linoleic acid metabolism_Homo sapiens_hsa005911.40309243
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38132551
24Fat digestion and absorption_Homo sapiens_hsa049751.34619227
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34355847
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32592226
27Alzheimers disease_Homo sapiens_hsa050101.24100609
28Arachidonic acid metabolism_Homo sapiens_hsa005901.15004171
29Phagosome_Homo sapiens_hsa041451.14094424
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13334628
31Ribosome_Homo sapiens_hsa030101.09232636
32Caffeine metabolism_Homo sapiens_hsa002321.08489478
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07196232
34Cardiac muscle contraction_Homo sapiens_hsa042601.06953157
35Tuberculosis_Homo sapiens_hsa051521.04747886
36Phototransduction_Homo sapiens_hsa047441.03381530
37Lysosome_Homo sapiens_hsa041421.01929011
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95301629
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93687217
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92944094
41Mineral absorption_Homo sapiens_hsa049780.91705928
42Huntingtons disease_Homo sapiens_hsa050160.91481257
43Chemical carcinogenesis_Homo sapiens_hsa052040.89797200
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89423323
45Systemic lupus erythematosus_Homo sapiens_hsa053220.86819210
46Peroxisome_Homo sapiens_hsa041460.81978572
47Tryptophan metabolism_Homo sapiens_hsa003800.81043749
48Ether lipid metabolism_Homo sapiens_hsa005650.78547690
49Salmonella infection_Homo sapiens_hsa051320.72944640
50Nitrogen metabolism_Homo sapiens_hsa009100.72808534
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.72684804
52Glutathione metabolism_Homo sapiens_hsa004800.72196361
53Malaria_Homo sapiens_hsa051440.71910923
54Regulation of autophagy_Homo sapiens_hsa041400.71650678
55Pertussis_Homo sapiens_hsa051330.69318768
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68943221
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.66626543
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63335659
59Toxoplasmosis_Homo sapiens_hsa051450.63151405
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.62970457
61Herpes simplex infection_Homo sapiens_hsa051680.61232763
62Renin-angiotensin system_Homo sapiens_hsa046140.60086805
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59802612
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59665575
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59038445
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55262374
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53281952
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53255659
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51925043
70Retinol metabolism_Homo sapiens_hsa008300.51431301
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50192388
72Vitamin digestion and absorption_Homo sapiens_hsa049770.49625346
73Olfactory transduction_Homo sapiens_hsa047400.49423210
74Platelet activation_Homo sapiens_hsa046110.48549001
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48070371
76Influenza A_Homo sapiens_hsa051640.47538271
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46565058
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.46391704
79Shigellosis_Homo sapiens_hsa051310.45705701
80Osteoclast differentiation_Homo sapiens_hsa043800.45690181
81Butanoate metabolism_Homo sapiens_hsa006500.45129187
82Fatty acid elongation_Homo sapiens_hsa000620.44890150
83Chemokine signaling pathway_Homo sapiens_hsa040620.43133976
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41622996
85Synaptic vesicle cycle_Homo sapiens_hsa047210.41554132
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40540152
87T cell receptor signaling pathway_Homo sapiens_hsa046600.40504685
88Legionellosis_Homo sapiens_hsa051340.38790893
89Vibrio cholerae infection_Homo sapiens_hsa051100.38014628
90Glycerolipid metabolism_Homo sapiens_hsa005610.37023400
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.35702833
92Arginine and proline metabolism_Homo sapiens_hsa003300.34406640
93TNF signaling pathway_Homo sapiens_hsa046680.30983396
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.30633656
95Metabolic pathways_Homo sapiens_hsa011000.28265439
96PPAR signaling pathway_Homo sapiens_hsa033200.27197077
97Other glycan degradation_Homo sapiens_hsa005110.24800893
98Starch and sucrose metabolism_Homo sapiens_hsa005000.22727731
99Protein export_Homo sapiens_hsa030600.21627024
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.20416816

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