FTH1P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chemokine-mediated signaling pathway (GO:0070099)6.20233292
2sequestering of actin monomers (GO:0042989)5.26052975
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85078698
4phagocytosis, engulfment (GO:0006911)4.55122461
5granulocyte activation (GO:0036230)4.40781247
6regulation of chronic inflammatory response (GO:0002676)4.29208850
7negative regulation of vascular permeability (GO:0043116)4.24065728
8positive regulation of T cell apoptotic process (GO:0070234)4.20964550
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.10903994
10neutrophil activation (GO:0042119)3.93511176
11thrombin receptor signaling pathway (GO:0070493)3.88475007
12positive regulation of actin filament depolymerization (GO:0030836)3.85631267
13membrane invagination (GO:0010324)3.84439696
14negative regulation of thymocyte apoptotic process (GO:0070244)3.80010103
15negative regulation of lipid storage (GO:0010888)3.76833636
16regulation of vitamin D biosynthetic process (GO:0060556)3.63124251
17positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.61499441
18positive regulation of lymphocyte apoptotic process (GO:0070230)3.59687816
19eosinophil chemotaxis (GO:0048245)3.59006289
20negative regulation of T cell apoptotic process (GO:0070233)3.57682811
21regulation of immunoglobulin secretion (GO:0051023)3.52020301
22cell adhesion mediated by integrin (GO:0033627)3.47443876
23positive regulation of vascular permeability (GO:0043117)3.46493727
24actin nucleation (GO:0045010)3.42339765
25regulation of cytokine secretion involved in immune response (GO:0002739)3.39159581
26mitochondrial calcium ion transport (GO:0006851)3.38796556
27hemoglobin metabolic process (GO:0020027)3.38276667
28oligosaccharide catabolic process (GO:0009313)3.36086499
29positive regulation of monocyte chemotaxis (GO:0090026)3.29360285
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.25740797
31positive regulation of interleukin-8 secretion (GO:2000484)3.23955955
32response to muscle activity (GO:0014850)3.22802117
33positive regulation of natural killer cell mediated immunity (GO:0002717)3.15758202
34eosinophil migration (GO:0072677)3.15236955
35negative regulation of nitric oxide biosynthetic process (GO:0045019)3.13883427
36regulation of T cell apoptotic process (GO:0070232)3.13109581
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.12680282
38regulation of mononuclear cell migration (GO:0071675)3.10610296
39monocyte chemotaxis (GO:0002548)3.04542605
40neutrophil activation involved in immune response (GO:0002283)3.02212327
41positive regulation of leukocyte apoptotic process (GO:2000108)3.00660044
42platelet dense granule organization (GO:0060155)2.99379593
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.92678596
44regulation of transforming growth factor beta2 production (GO:0032909)2.91419405
45mitochondrial calcium ion homeostasis (GO:0051560)2.90810383
46negative regulation of mast cell activation (GO:0033004)2.90037055
47cAMP catabolic process (GO:0006198)2.86429345
48cellular response to zinc ion (GO:0071294)2.85643701
49negative regulation of macrophage differentiation (GO:0045650)2.84500427
50positive regulation of Rho protein signal transduction (GO:0035025)2.83821924
51protein localization to lysosome (GO:0061462)2.80498922
52protein localization to vacuole (GO:0072665)2.80498922
53positive regulation of lamellipodium assembly (GO:0010592)2.80481156
54substrate-dependent cell migration (GO:0006929)2.76254199
55regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.76186515
56regulation of thymocyte apoptotic process (GO:0070243)2.74879635
57pyrimidine ribonucleoside catabolic process (GO:0046133)2.74445419
58positive regulation of calcium-mediated signaling (GO:0050850)2.73852330
59positive regulation of heat generation (GO:0031652)2.73669502
60regulation of fever generation (GO:0031620)2.72402826
61cytidine deamination (GO:0009972)2.72041490
62cytidine metabolic process (GO:0046087)2.72041490
63cytidine catabolic process (GO:0006216)2.72041490
64regulation of macrophage differentiation (GO:0045649)2.70255005
65positive regulation of leukocyte degranulation (GO:0043302)2.66270057
66regulation of monocyte chemotaxis (GO:0090025)2.64170889
67localization within membrane (GO:0051668)2.64076411
68positive regulation of smooth muscle contraction (GO:0045987)2.63935494
69positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61962484
70negative regulation by host of viral transcription (GO:0043922)2.61396183
71pyrimidine nucleoside catabolic process (GO:0046135)2.60921017
72regulation of vitamin metabolic process (GO:0030656)2.60854813
73positive regulation of macrophage differentiation (GO:0045651)2.59894697
74regulation of natural killer cell mediated immunity (GO:0002715)2.59612621
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.59612621
76substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59417725
77substrate-independent telencephalic tangential migration (GO:0021826)2.59417725
78regulation of chemokine secretion (GO:0090196)2.57650059
79protein neddylation (GO:0045116)2.56922371
80cyclooxygenase pathway (GO:0019371)2.55820235
81response to xenobiotic stimulus (GO:0009410)2.54461510
82regulation of alkaline phosphatase activity (GO:0010692)2.54336077
83DNA deamination (GO:0045006)2.51328793
84positive regulation of smooth muscle cell migration (GO:0014911)2.51274392
85regulation of transmission of nerve impulse (GO:0051969)2.50360529
86Golgi to plasma membrane protein transport (GO:0043001)2.48503353
87positive regulation of NF-kappaB import into nucleus (GO:0042346)2.47643086
88iron-sulfur cluster assembly (GO:0016226)2.45870579
89metallo-sulfur cluster assembly (GO:0031163)2.45870579
90positive regulation of interleukin-17 production (GO:0032740)2.44269203
91positive regulation of type 2 immune response (GO:0002830)2.43352941
92negative regulation of lymphocyte apoptotic process (GO:0070229)2.40701742
93positive regulation of positive chemotaxis (GO:0050927)2.39991051
94mesodermal cell differentiation (GO:0048333)2.39662059
95positive regulation of chemokine biosynthetic process (GO:0045080)2.39465622
96intracellular pH reduction (GO:0051452)2.38699628
97polyamine biosynthetic process (GO:0006596)2.38404394
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38240252
99positive regulation of p38MAPK cascade (GO:1900745)2.36251152
100regulation of interleukin-17 production (GO:0032660)2.35533306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.61757720
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.48475431
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.09717947
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91729844
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88464046
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82083807
7ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.74758827
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64710823
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52110350
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46722716
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.38127196
12JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31719109
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28554095
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.27301866
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22212242
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19751587
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19284297
18JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15101630
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11152506
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.10928894
21ELK1_19687146_ChIP-ChIP_HELA_Human2.06027123
22CJUN_26792858_Chip-Seq_BT549_Human2.04161156
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02017527
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96890988
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89436446
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86962195
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86929773
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.80106238
29ELK1_22589737_ChIP-Seq_MCF10A_Human1.75493062
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.74716924
31TFEB_21752829_ChIP-Seq_HELA_Human1.73236078
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70397114
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.65571334
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.64873653
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63719396
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62306297
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.59556124
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57802261
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54431817
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46711351
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44493431
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41714107
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39334895
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.36204103
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33741886
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33195395
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32510456
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32406806
49SPI1_23547873_ChIP-Seq_NB4_Human1.29941291
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25466714
51SPI1_23127762_ChIP-Seq_K562_Human1.24885007
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24821484
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24821484
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24590596
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20488958
56DCP1A_22483619_ChIP-Seq_HELA_Human1.18379259
57MYB_26560356_Chip-Seq_TH2_Human1.18097358
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16396415
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.15694916
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15485490
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.15473419
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15307736
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12420597
64BRD4_25478319_ChIP-Seq_HGPS_Human1.09412492
65ZNF263_19887448_ChIP-Seq_K562_Human1.09205810
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08469705
67VDR_23849224_ChIP-Seq_CD4+_Human1.06391796
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06247280
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06158108
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04466089
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01798755
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01786857
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01786857
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99100617
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99034953
76SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98033584
77SCL_19346495_ChIP-Seq_HPC-7_Human0.97021272
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95316391
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94416787
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94146360
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94028699
82NFYB_21822215_ChIP-Seq_K562_Human0.93025205
83GATA3_27048872_Chip-Seq_THYMUS_Human0.92106479
84NFYA_21822215_ChIP-Seq_K562_Human0.92035478
85TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91111618
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89943558
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89410271
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89302449
89RUNX_20019798_ChIP-Seq_JUKART_Human0.88069622
90SPI1_20517297_ChIP-Seq_HL60_Human0.87022928
91GATA3_26560356_Chip-Seq_TH2_Human0.83038973
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82677782
93HNFA_21074721_ChIP-Seq_CACO-2_Human0.80439415
94RUNX1_22412390_ChIP-Seq_EML_Mouse0.80168318
95AR_20517297_ChIP-Seq_VCAP_Human0.79110963
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78925291
97GABP_19822575_ChIP-Seq_HepG2_Human0.78598267
98MAF_26560356_Chip-Seq_TH1_Human0.78306275
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78165444
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77930471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.12375845
2MP0006082_CNS_inflammation3.00601408
3MP0002254_reproductive_system_inflammat3.00138200
4MP0003436_decreased_susceptibility_to2.98016933
5MP0009764_decreased_sensitivity_to2.93358730
6MP0002148_abnormal_hypersensitivity_rea2.93143259
7MP0008004_abnormal_stomach_pH2.82023360
8MP0003724_increased_susceptibility_to2.74016241
9MP0005058_abnormal_lysosome_morphology2.69731255
10MP0002877_abnormal_melanocyte_morpholog2.63005927
11MP0005671_abnormal_response_to2.53433961
12MP0003303_peritoneal_inflammation2.52361063
13MP0005464_abnormal_platelet_physiology2.35846714
14MP0009785_altered_susceptibility_to2.35837526
15MP0000343_altered_response_to2.19236365
16MP0005000_abnormal_immune_tolerance2.16345717
17MP0002332_abnormal_exercise_endurance2.15230716
18MP0003075_altered_response_to2.13773004
19MP0006054_spinal_hemorrhage2.06280997
20MP0004185_abnormal_adipocyte_glucose2.04588743
21MP0004130_abnormal_muscle_cell1.92053443
22MP0005165_increased_susceptibility_to1.89638551
23MP0003448_altered_tumor_morphology1.88930474
24MP0001533_abnormal_skeleton_physiology1.88116908
25MP0001873_stomach_inflammation1.87093614
26MP0001835_abnormal_antigen_presentation1.82413168
27MP0003646_muscle_fatigue1.76448746
28MP0004084_abnormal_cardiac_muscle1.75859753
29MP0002837_dystrophic_cardiac_calcinosis1.71845506
30MP0004510_myositis1.69529877
31MP0001853_heart_inflammation1.69234120
32MP0003300_gastrointestinal_ulcer1.62619012
33MP0002723_abnormal_immune_serum1.61477654
34MP0001542_abnormal_bone_strength1.59015431
35MP0003656_abnormal_erythrocyte_physiolo1.53708380
36MP0002419_abnormal_innate_immunity1.51760087
37MP0003186_abnormal_redox_activity1.50752082
38MP0009840_abnormal_foam_cell1.42282341
39MP0009765_abnormal_xenobiotic_induced1.41282808
40MP0000858_altered_metastatic_potential1.39408173
41MP0010155_abnormal_intestine_physiology1.36005372
42MP0002452_abnormal_antigen_presenting1.33953240
43MP0009333_abnormal_splenocyte_physiolog1.33887332
44MP0001727_abnormal_embryo_implantation1.33166012
45MP0001845_abnormal_inflammatory_respons1.33095881
46MP0003045_fibrosis1.32117014
47MP0008469_abnormal_protein_level1.29567487
48MP0001790_abnormal_immune_system1.27277036
49MP0005387_immune_system_phenotype1.27277036
50MP0005166_decreased_susceptibility_to1.22806014
51MP0002420_abnormal_adaptive_immunity1.19855582
52MP0000685_abnormal_immune_system1.18707331
53MP0004233_abnormal_muscle_weight1.17446553
54MP0001819_abnormal_immune_cell1.16530376
55MP0005623_abnormal_meninges_morphology1.15728376
56MP0009763_increased_sensitivity_to1.15607167
57MP0002405_respiratory_system_inflammati1.15558123
58MP0002102_abnormal_ear_morphology1.14880838
59MP0005025_abnormal_response_to1.13988480
60MP0001800_abnormal_humoral_immune1.13233811
61MP0003172_abnormal_lysosome_physiology1.13230164
62MP0004215_abnormal_myocardial_fiber1.13004114
63MP0005410_abnormal_fertilization1.11051521
64MP0005023_abnormal_wound_healing1.03966968
65MP0005167_abnormal_blood-brain_barrier1.00534153
66MP0002822_catalepsy1.00215699
67MP0000750_abnormal_muscle_regeneration0.98845672
68MP0005164_abnormal_response_to0.97856558
69MP0003191_abnormal_cellular_cholesterol0.96076722
70MP0005666_abnormal_adipose_tissue0.95860682
71MP0003221_abnormal_cardiomyocyte_apopto0.94058313
72MP0001663_abnormal_digestive_system0.93269232
73MP0005645_abnormal_hypothalamus_physiol0.93162917
74MP0001881_abnormal_mammary_gland0.92260873
75MP0000465_gastrointestinal_hemorrhage0.91988802
76MP0000230_abnormal_systemic_arterial0.91878695
77MP0004036_abnormal_muscle_relaxation0.91249880
78MP0002972_abnormal_cardiac_muscle0.90754230
79MP0005390_skeleton_phenotype0.90601940
80MP0009384_cardiac_valve_regurgitation0.89893567
81MP0000627_abnormal_mammary_gland0.88330037
82MP0005266_abnormal_metabolism0.87827660
83MP0008007_abnormal_cellular_replicative0.86466947
84MP0004043_abnormal_pH_regulation0.85867975
85MP0002998_abnormal_bone_remodeling0.85142693
86MP0003453_abnormal_keratinocyte_physiol0.84932380
87MP0003763_abnormal_thymus_physiology0.83490941
88MP0009697_abnormal_copulation0.82882129
89MP0004947_skin_inflammation0.81760892
90MP0002090_abnormal_vision0.80961412
91MP0000716_abnormal_immune_system0.76621833
92MP0000689_abnormal_spleen_morphology0.74902208
93MP0006072_abnormal_retinal_apoptosis0.74299200
94MP0005330_cardiomyopathy0.74288968
95MP0001879_abnormal_lymphatic_vessel0.73082056
96MP0002136_abnormal_kidney_physiology0.72443492
97MP0000678_abnormal_parathyroid_gland0.71779945
98MP0000249_abnormal_blood_vessel0.69700508
99MP0002429_abnormal_blood_cell0.68753082
100MP0003137_abnormal_impulse_conducting0.68239643

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.20235319
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.20235319
3Abnormality of glycolipid metabolism (HP:0010969)5.20235319
4Vertebral compression fractures (HP:0002953)4.75968862
5Autoamputation (HP:0001218)4.63553667
6Aplastic anemia (HP:0001915)4.42687954
7Vacuolated lymphocytes (HP:0001922)4.02327395
8Abnormality of macrophages (HP:0004311)3.46103924
9Abnormality of proline metabolism (HP:0010907)3.41466535
10Hydroxyprolinuria (HP:0003080)3.41466535
11Stenosis of the external auditory canal (HP:0000402)3.40461312
12Petechiae (HP:0000967)3.31664053
13Tetraparesis (HP:0002273)3.26393003
14Increased IgM level (HP:0003496)3.24661583
15Dysostosis multiplex (HP:0000943)3.21764111
16Abnormality of cells of the erythroid lineage (HP:0012130)3.17306667
17Spondylolisthesis (HP:0003302)3.12778889
18Stomatitis (HP:0010280)3.12083925
19T lymphocytopenia (HP:0005403)3.10454868
20Purpura (HP:0000979)3.02086671
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73941492
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73941492
23Amyotrophic lateral sclerosis (HP:0007354)2.71845906
24Bundle branch block (HP:0011710)2.70608608
25Absent frontal sinuses (HP:0002688)2.66547933
26Increased intramyocellular lipid droplets (HP:0012240)2.65667279
27Abnormality of T cell number (HP:0011839)2.60876582
28Increased mean platelet volume (HP:0011877)2.58739514
29Abnormality of alanine metabolism (HP:0010916)2.51395344
30Hyperalaninemia (HP:0003348)2.51395344
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51395344
32Autoimmune thrombocytopenia (HP:0001973)2.49966846
33IgG deficiency (HP:0004315)2.44357323
34Insidious onset (HP:0003587)2.41413192
35Termporal pattern (HP:0011008)2.41413192
36Abnormal platelet volume (HP:0011876)2.41035601
37Atrophy/Degeneration involving motor neurons (HP:0007373)2.37483528
38Upper limb muscle weakness (HP:0003484)2.34090871
39Abnormal mitochondria in muscle tissue (HP:0008316)2.33723556
40Radial bowing (HP:0002986)2.33657188
41Generalized aminoaciduria (HP:0002909)2.30368334
42Myocardial infarction (HP:0001658)2.30011117
43Increased serum ferritin (HP:0003281)2.29016596
44Increased muscle lipid content (HP:0009058)2.28916375
45Prolonged bleeding time (HP:0003010)2.28740040
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22314659
47Hepatocellular necrosis (HP:0001404)2.19705583
48Renal Fanconi syndrome (HP:0001994)2.17558485
49Mutism (HP:0002300)2.12687023
50Increased cerebral lipofuscin (HP:0011813)2.12270185
51Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.10205428
52Disinhibition (HP:0000734)2.09308208
53Menorrhagia (HP:0000132)2.09134802
54Prolonged neonatal jaundice (HP:0006579)2.07441259
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04082089
56Upper motor neuron abnormality (HP:0002127)2.01428138
57Supraventricular tachycardia (HP:0004755)2.01155873
58Metaphyseal dysplasia (HP:0100255)2.00960865
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97947093
60Neonatal hypoglycemia (HP:0001998)1.96262195
61Elevated erythrocyte sedimentation rate (HP:0003565)1.95817120
62Abnormality of the costochondral junction (HP:0000919)1.94977766
63Mitochondrial inheritance (HP:0001427)1.94868585
64Autoimmune hemolytic anemia (HP:0001890)1.94186841
65Abnormality of the distal phalanges of the toes (HP:0010182)1.93071951
66Acute necrotizing encephalopathy (HP:0006965)1.91450652
67Failure to thrive in infancy (HP:0001531)1.91207143
68Abnormality of iron homeostasis (HP:0011031)1.91102922
69Primary atrial arrhythmia (HP:0001692)1.90910617
70Cutaneous melanoma (HP:0012056)1.89515498
71Left ventricular hypertrophy (HP:0001712)1.88486088
72Supraventricular arrhythmia (HP:0005115)1.88130075
73Loss of speech (HP:0002371)1.85006674
74Hepatosplenomegaly (HP:0001433)1.84451829
75Abnormality of transition element cation homeostasis (HP:0011030)1.83191858
76Entropion (HP:0000621)1.82763897
77Abnormal neuron morphology (HP:0012757)1.82501342
78Abnormality of the motor neurons (HP:0002450)1.82501342
79Hypoproteinemia (HP:0003075)1.82337411
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82282303
81Atrial fibrillation (HP:0005110)1.82191719
82Achilles tendon contracture (HP:0001771)1.82009273
83Flared iliac wings (HP:0002869)1.81939795
84Axonal loss (HP:0003447)1.81680849
85Hypoalbuminemia (HP:0003073)1.81021087
86Abnormal albumin level (HP:0012116)1.81021087
87Hepatic necrosis (HP:0002605)1.79551641
88Increased CSF lactate (HP:0002490)1.78880281
89Abolished electroretinogram (ERG) (HP:0000550)1.78486131
90Acute hepatic failure (HP:0006554)1.75987695
91Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75147037
92Episodic fever (HP:0001954)1.72693065
93Fasciculations (HP:0002380)1.72666140
94Palpitations (HP:0001962)1.68952243
95Abnormality of the frontal sinuses (HP:0002687)1.67385039
96Zonular cataract (HP:0010920)1.66608178
97Bicuspid aortic valve (HP:0001647)1.66128573
98Combined immunodeficiency (HP:0005387)1.66049617
99Abnormality of the Achilles tendon (HP:0005109)1.65390649
1003-Methylglutaconic aciduria (HP:0003535)1.64678289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.99764831
2TESK23.68961927
3LIMK13.03647444
4BMPR23.02641187
5KDR2.98529872
6EIF2AK12.91913271
7MYLK2.76546792
8TESK12.62146862
9MAP3K122.56577354
10ILK2.44110828
11CAMKK22.37289700
12TXK2.15705442
13TTN2.10442614
14ERBB32.08791683
15PIM22.04420576
16CDK192.01847839
17CDK81.92312472
18TRIB31.88831899
19SCYL21.87713859
20GRK71.81562200
21TBK11.75310095
22TAOK21.70463158
23DMPK1.66024657
24NME21.63954250
25ERBB41.61872686
26MST1R1.60479101
27PDK21.48747505
28DYRK31.39240827
29CDK91.36256612
30ADRBK21.36231613
31EPHB21.33200802
32BCKDK1.30514458
33MAP3K111.30315858
34PKN11.18451798
35BRSK21.13009005
36TEC1.09501715
37PTK21.06413386
38BCR1.05140651
39DAPK31.02261177
40CAMK2B0.96740864
41IKBKB0.96355652
42LATS20.89656806
43MAP3K50.88633341
44CAMK2D0.86885617
45ZAP700.86329240
46BMX0.85632206
47SYK0.85329705
48PAK60.82994548
49MST40.78371882
50MAP2K70.78034649
51PINK10.77102760
52PAK10.76635687
53ABL20.76240980
54PRKCE0.73968325
55TGFBR20.72583519
56CAMK2G0.72271307
57CSK0.71382856
58EIF2AK30.70496883
59IRAK40.67030438
60DYRK1B0.66509801
61MAPKAPK30.65404153
62MAP3K40.61980601
63PAK30.59403370
64SIK30.58670786
65PAK40.56994529
66PAK20.55331203
67CDC70.54827911
68BTK0.54646855
69MARK30.50351743
70PRKD10.50069504
71JAK30.48756935
72MET0.48732364
73LCK0.48467791
74CHUK0.44824346
75ITK0.44698846
76RPS6KA40.44434053
77PTK2B0.43876835
78CSF1R0.43774217
79MAP4K20.43525822
80CAMK2A0.43130425
81TAOK30.41990663
82ROCK20.40269850
83GRK50.39979892
84INSR0.39507804
85MAP4K10.39464249
86ROCK10.39142832
87MAP3K70.36931350
88PRKCD0.36092823
89TIE10.35850688
90PDGFRB0.35596767
91MATK0.35273733
92AKT30.33022040
93DAPK10.32145947
94RPS6KA50.31855113
95CSNK1G30.31837568
96NEK10.31161119
97PLK20.30717412
98CDK140.29256155
99NEK90.28303560
100SIK20.28244600

Predicted pathways (KEGG)

RankGene SetZ-score
1Rheumatoid arthritis_Homo sapiens_hsa053233.17342913
2Salmonella infection_Homo sapiens_hsa051322.99583884
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46998960
4Legionellosis_Homo sapiens_hsa051342.39904683
5Hematopoietic cell lineage_Homo sapiens_hsa046402.39556698
6Shigellosis_Homo sapiens_hsa051312.31201186
7Primary immunodeficiency_Homo sapiens_hsa053402.28326206
8Malaria_Homo sapiens_hsa051442.21403725
9Collecting duct acid secretion_Homo sapiens_hsa049662.15183195
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13243504
11Oxidative phosphorylation_Homo sapiens_hsa001902.06939501
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.06491755
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.01946517
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.99782530
15Lysosome_Homo sapiens_hsa041421.89013201
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82288697
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.77684613
18Viral myocarditis_Homo sapiens_hsa054161.61039132
19Sulfur metabolism_Homo sapiens_hsa009201.60791345
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59437195
21Proteasome_Homo sapiens_hsa030501.57697714
22Phagosome_Homo sapiens_hsa041451.57369138
23Osteoclast differentiation_Homo sapiens_hsa043801.56857281
24Graft-versus-host disease_Homo sapiens_hsa053321.56841094
25TNF signaling pathway_Homo sapiens_hsa046681.56821531
26Antigen processing and presentation_Homo sapiens_hsa046121.55275615
27Parkinsons disease_Homo sapiens_hsa050121.54378134
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49668593
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45953803
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44902933
31Vibrio cholerae infection_Homo sapiens_hsa051101.36654937
32Pertussis_Homo sapiens_hsa051331.35542770
33Other glycan degradation_Homo sapiens_hsa005111.35158621
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34986424
35African trypanosomiasis_Homo sapiens_hsa051431.34397195
36Allograft rejection_Homo sapiens_hsa053301.33274127
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32464489
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32406062
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30387654
40Regulation of autophagy_Homo sapiens_hsa041401.26327241
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17343804
42Endocytosis_Homo sapiens_hsa041441.17211315
43T cell receptor signaling pathway_Homo sapiens_hsa046601.14125088
44Tuberculosis_Homo sapiens_hsa051521.13841335
45Chemokine signaling pathway_Homo sapiens_hsa040621.13080637
46Asthma_Homo sapiens_hsa053101.10902990
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10357721
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07701822
49Autoimmune thyroid disease_Homo sapiens_hsa053201.05126891
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.96665245
51Platelet activation_Homo sapiens_hsa046110.94880219
52Cardiac muscle contraction_Homo sapiens_hsa042600.93949995
53Morphine addiction_Homo sapiens_hsa050320.93112890
54Measles_Homo sapiens_hsa051620.87497957
55Prion diseases_Homo sapiens_hsa050200.87445555
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86712069
57Leishmaniasis_Homo sapiens_hsa051400.81672566
58Dilated cardiomyopathy_Homo sapiens_hsa054140.79907564
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77517132
60Type I diabetes mellitus_Homo sapiens_hsa049400.76678649
61Huntingtons disease_Homo sapiens_hsa050160.76671487
62Amoebiasis_Homo sapiens_hsa051460.73351235
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.72943822
64Herpes simplex infection_Homo sapiens_hsa051680.71731772
65Influenza A_Homo sapiens_hsa051640.71234674
66Synaptic vesicle cycle_Homo sapiens_hsa047210.70349146
67Toxoplasmosis_Homo sapiens_hsa051450.68541143
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68411840
69Alzheimers disease_Homo sapiens_hsa050100.68355841
70Epstein-Barr virus infection_Homo sapiens_hsa051690.67602645
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.67069210
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63485679
73Systemic lupus erythematosus_Homo sapiens_hsa053220.59683046
74Phototransduction_Homo sapiens_hsa047440.56915643
75mTOR signaling pathway_Homo sapiens_hsa041500.51813876
76Bladder cancer_Homo sapiens_hsa052190.48541731
77Pancreatic cancer_Homo sapiens_hsa052120.47792855
78Staphylococcus aureus infection_Homo sapiens_hsa051500.45944677
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41877154
80Apoptosis_Homo sapiens_hsa042100.41582717
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41545837
82Circadian rhythm_Homo sapiens_hsa047100.40469121
83Fatty acid biosynthesis_Homo sapiens_hsa000610.38425375
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37010491
85Ras signaling pathway_Homo sapiens_hsa040140.36613954
86Alcoholism_Homo sapiens_hsa050340.36158599
87Purine metabolism_Homo sapiens_hsa002300.35679859
88Renal cell carcinoma_Homo sapiens_hsa052110.34082155
89Viral carcinogenesis_Homo sapiens_hsa052030.32375772
90GABAergic synapse_Homo sapiens_hsa047270.29375187
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27939949
92Mineral absorption_Homo sapiens_hsa049780.26320107
93Glutathione metabolism_Homo sapiens_hsa004800.25876852
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.23018291
95Hepatitis C_Homo sapiens_hsa051600.22292878
96Small cell lung cancer_Homo sapiens_hsa052220.22288092
97Pyrimidine metabolism_Homo sapiens_hsa002400.21472591
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20113841
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19045198
100Protein export_Homo sapiens_hsa030600.17936772

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