FTH1P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.10417260
2cytidine metabolic process (GO:0046087)5.56480518
3cytidine catabolic process (GO:0006216)5.56480518
4cytidine deamination (GO:0009972)5.56480518
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.17733711
6protein neddylation (GO:0045116)5.17165324
7ATP synthesis coupled proton transport (GO:0015986)4.87686680
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.87686680
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.80343679
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38232734
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.12889933
12respiratory electron transport chain (GO:0022904)3.92140961
13electron transport chain (GO:0022900)3.88465495
14sequestering of actin monomers (GO:0042989)3.81165692
15platelet dense granule organization (GO:0060155)3.74728236
16otic vesicle formation (GO:0030916)3.62235830
17positive regulation of T cell apoptotic process (GO:0070234)3.61759067
18protein complex biogenesis (GO:0070271)3.46033794
19immunoglobulin mediated immune response (GO:0016064)3.39288264
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34460752
21negative regulation of heart rate (GO:0010459)3.29027935
22autophagic vacuole fusion (GO:0000046)3.28471918
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26015474
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26015474
25eosinophil chemotaxis (GO:0048245)3.22947988
26regulation of chronic inflammatory response (GO:0002676)3.18471419
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17976623
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.17976623
29NADH dehydrogenase complex assembly (GO:0010257)3.17976623
30regulation of regulatory T cell differentiation (GO:0045589)3.12674703
31actin nucleation (GO:0045010)3.12066242
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11511809
33neutrophil activation involved in immune response (GO:0002283)3.06814709
34pyrimidine nucleoside catabolic process (GO:0046135)3.05172857
35hydrogen ion transmembrane transport (GO:1902600)3.03120970
36ATP biosynthetic process (GO:0006754)3.02867585
37negative regulation of membrane potential (GO:0045837)3.00320656
38positive regulation of lymphocyte apoptotic process (GO:0070230)2.98411009
39eosinophil migration (GO:0072677)2.90514089
40proton transport (GO:0015992)2.88207869
41positive regulation of prostaglandin secretion (GO:0032308)2.88026063
42mitochondrial respiratory chain complex assembly (GO:0033108)2.87889987
43hydrogen transport (GO:0006818)2.82347380
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82280725
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76705745
46neutrophil activation (GO:0042119)2.74599585
47negative regulation of T cell apoptotic process (GO:0070233)2.73818894
48organelle membrane fusion (GO:0090174)2.69106441
49positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.64291779
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64248277
51chaperone-mediated protein transport (GO:0072321)2.64120763
52behavioral response to nicotine (GO:0035095)2.63837104
53positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62788657
54response to pheromone (GO:0019236)2.62097468
55positive regulation of calcium-mediated signaling (GO:0050850)2.60423819
56granulocyte activation (GO:0036230)2.60394071
57purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56885595
58B cell mediated immunity (GO:0019724)2.56240760
59positive regulation of interleukin-8 secretion (GO:2000484)2.55743361
60regulation of T cell apoptotic process (GO:0070232)2.55393832
61ribosomal small subunit assembly (GO:0000028)2.54840742
62T cell costimulation (GO:0031295)2.49180587
63lymphocyte costimulation (GO:0031294)2.47387714
64response to interferon-beta (GO:0035456)2.46007693
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.45959337
66GPI anchor metabolic process (GO:0006505)2.45709407
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.45351883
68regulation of T cell mediated cytotoxicity (GO:0001914)2.44720891
69proteasome assembly (GO:0043248)2.42711391
70cellular biogenic amine catabolic process (GO:0042402)2.41986540
71amine catabolic process (GO:0009310)2.41986540
72positive regulation of mast cell activation (GO:0033005)2.41927331
73regulation of antigen processing and presentation (GO:0002577)2.40185514
74regulation of activation of Janus kinase activity (GO:0010533)2.39042918
75regulation of leukocyte mediated cytotoxicity (GO:0001910)2.38984178
76GPI anchor biosynthetic process (GO:0006506)2.38046985
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.37323006
78pyrimidine-containing compound catabolic process (GO:0072529)2.36353000
79regulation of interleukin-8 secretion (GO:2000482)2.35141474
80positive regulation of interleukin-1 beta secretion (GO:0050718)2.34697602
81positive regulation of gamma-delta T cell activation (GO:0046645)2.33596814
82positive regulation of defense response to virus by host (GO:0002230)2.33030112
83positive regulation of fatty acid transport (GO:2000193)2.31530629
84cytochrome complex assembly (GO:0017004)2.30938834
85negative regulation of calcium ion transport into cytosol (GO:0010523)2.30732508
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.30338641
87positive regulation of mast cell degranulation (GO:0043306)2.30338641
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.30156794
89protein-cofactor linkage (GO:0018065)2.30154175
90negative regulation of interleukin-1 beta production (GO:0032691)2.30050989
91positive regulation of antigen processing and presentation (GO:0002579)2.29931245
92limb bud formation (GO:0060174)2.28868186
93adaptation of signaling pathway (GO:0023058)2.28635534
94negative regulation of T cell differentiation in thymus (GO:0033085)2.28509853
95negative regulation by host of viral transcription (GO:0043922)2.27796065
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.27243155
97sulfation (GO:0051923)2.26550002
98maturation of SSU-rRNA (GO:0030490)2.25476832
99regulation of inflammatory response to antigenic stimulus (GO:0002861)2.25351468
100S-adenosylmethionine metabolic process (GO:0046500)2.24456105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03432758
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.95274134
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.77870017
4VDR_22108803_ChIP-Seq_LS180_Human3.47522737
5EZH2_22144423_ChIP-Seq_EOC_Human3.38676737
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99502718
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96997900
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.66236618
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.45058681
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.26391276
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94643276
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94591102
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94419327
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84183507
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81035236
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73838831
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67827001
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66054550
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64433058
20VDR_23849224_ChIP-Seq_CD4+_Human1.62488750
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62141481
22BCL6_27268052_Chip-Seq_Bcells_Human1.58309215
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.57484662
24ZNF274_21170338_ChIP-Seq_K562_Hela1.57250680
25TAF2_19829295_ChIP-Seq_ESCs_Human1.53946695
26PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.52216660
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51554602
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49926508
29STAT1_20625510_ChIP-Seq_HELA_Human1.49691628
30TP53_22573176_ChIP-Seq_HFKS_Human1.46827385
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45656911
32AR_20517297_ChIP-Seq_VCAP_Human1.44716199
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44114738
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42800728
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.42599783
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.42437683
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42249244
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41777770
39NANOG_20526341_ChIP-Seq_ESCs_Human1.41194425
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39778608
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39089549
42GATA3_26560356_Chip-Seq_TH2_Human1.39008492
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.33803208
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30591083
45ERG_20517297_ChIP-Seq_VCAP_Human1.30249370
46SOX2_19829295_ChIP-Seq_ESCs_Human1.23437932
47NANOG_19829295_ChIP-Seq_ESCs_Human1.23437932
48MYB_26560356_Chip-Seq_TH2_Human1.22949080
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20848237
50MYC_19829295_ChIP-Seq_ESCs_Human1.19908780
51CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19877009
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19804074
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19489969
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19384835
55FOXP3_21729870_ChIP-Seq_TREG_Human1.19356240
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19037043
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18942549
58NCOR_22424771_ChIP-Seq_293T_Human1.18677414
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17333384
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15526640
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15254463
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14641921
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.14641921
64P300_27268052_Chip-Seq_Bcells_Human1.10664731
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09085324
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08944257
67P53_21459846_ChIP-Seq_SAOS-2_Human1.06967658
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06648447
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04537602
70CTCF_20526341_ChIP-Seq_ESCs_Human1.04488079
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04274575
72GATA3_27048872_Chip-Seq_THYMUS_Human1.03060303
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.02073967
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.01001918
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99979311
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99774483
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98778600
78FOXH1_21741376_ChIP-Seq_ESCs_Human0.98185857
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.97353300
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96527377
81SA1_27219007_Chip-Seq_Bcells_Human0.96480781
82IGF1R_20145208_ChIP-Seq_DFB_Human0.96137107
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95687162
84RUNX_20019798_ChIP-Seq_JUKART_Human0.95551666
85E2F1_20622854_ChIP-Seq_HELA_Human0.95328547
86HTT_18923047_ChIP-ChIP_STHdh_Human0.94685190
87ERA_21632823_ChIP-Seq_H3396_Human0.94455861
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93448430
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92638481
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92242074
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92027679
92MYC_18940864_ChIP-ChIP_HL60_Human0.91781493
93SPI1_23547873_ChIP-Seq_NB4_Human0.90678615
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.90251923
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89841504
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.88999781
97SOX2_21211035_ChIP-Seq_LN229_Human0.88077713
98ER_23166858_ChIP-Seq_MCF-7_Human0.88051460
99SPI1_20517297_ChIP-Seq_HL60_Human0.86854183
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86043774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.87217210
2MP0000566_synostosis3.46908210
3MP0004147_increased_porphyrin_level3.03902464
4MP0001835_abnormal_antigen_presentation2.74703921
5MP0003724_increased_susceptibility_to2.70482426
6MP0003646_muscle_fatigue2.62550917
7MP0009785_altered_susceptibility_to2.54889374
8MP0003136_yellow_coat_color2.51297838
9MP0005670_abnormal_white_adipose2.47991944
10MP0002148_abnormal_hypersensitivity_rea2.45859818
11MP0005360_urolithiasis2.44229925
12MP0005464_abnormal_platelet_physiology2.34733699
13MP0009764_decreased_sensitivity_to2.20065744
14MP0005000_abnormal_immune_tolerance1.96714036
15MP0005646_abnormal_pituitary_gland1.83699049
16MP0002653_abnormal_ependyma_morphology1.76928911
17MP0004142_abnormal_muscle_tone1.76928576
18MP0010155_abnormal_intestine_physiology1.71728995
19MP0009379_abnormal_foot_pigmentation1.69501334
20MP0001800_abnormal_humoral_immune1.67892411
21MP0003436_decreased_susceptibility_to1.67724065
22MP0002736_abnormal_nociception_after1.66980168
23MP0005025_abnormal_response_to1.65204495
24MP0002723_abnormal_immune_serum1.63204766
25MP0008872_abnormal_physiological_respon1.61133038
26MP0002102_abnormal_ear_morphology1.55243761
27MP0004885_abnormal_endolymph1.53338009
28MP0002277_abnormal_respiratory_mucosa1.53153952
29MP0002876_abnormal_thyroid_physiology1.51831677
30MP0002837_dystrophic_cardiac_calcinosis1.51228535
31MP0009333_abnormal_splenocyte_physiolog1.50619605
32MP0000685_abnormal_immune_system1.50172630
33MP0000343_altered_response_to1.47868226
34MP0005377_hearing/vestibular/ear_phenot1.47552250
35MP0003878_abnormal_ear_physiology1.47552250
36MP0002420_abnormal_adaptive_immunity1.42955861
37MP0003011_delayed_dark_adaptation1.41906951
38MP0001819_abnormal_immune_cell1.40498069
39MP0002452_abnormal_antigen_presenting1.39952098
40MP0005387_immune_system_phenotype1.37866114
41MP0001790_abnormal_immune_system1.37866114
42MP0001968_abnormal_touch/_nociception1.35608279
43MP0005083_abnormal_biliary_tract1.31838273
44MP0002095_abnormal_skin_pigmentation1.26819946
45MP0001919_abnormal_reproductive_system1.26293503
46MP0001845_abnormal_inflammatory_respons1.24927791
47MP0003866_abnormal_defecation1.21535135
48MP0003186_abnormal_redox_activity1.19243020
49MP0008875_abnormal_xenobiotic_pharmacok1.18988698
50MP0006292_abnormal_olfactory_placode1.18964703
51MP0005084_abnormal_gallbladder_morpholo1.17146019
52MP0008004_abnormal_stomach_pH1.16713988
53MP0001533_abnormal_skeleton_physiology1.15572329
54MP0002138_abnormal_hepatobiliary_system1.14850109
55MP0009765_abnormal_xenobiotic_induced1.10082479
56MP0004145_abnormal_muscle_electrophysio1.09632762
57MP0005410_abnormal_fertilization1.09590840
58MP0002419_abnormal_innate_immunity1.09376295
59MP0001986_abnormal_taste_sensitivity1.07243268
60MP0000372_irregular_coat_pigmentation1.07179191
61MP0005551_abnormal_eye_electrophysiolog1.06911196
62MP0005645_abnormal_hypothalamus_physiol1.06379419
63MP0001905_abnormal_dopamine_level1.05530527
64MP0000716_abnormal_immune_system1.00528692
65MP0005636_abnormal_mineral_homeostasis0.98982170
66MP0009763_increased_sensitivity_to0.98624114
67MP0006036_abnormal_mitochondrial_physio0.96609428
68MP0006082_CNS_inflammation0.96115182
69MP0001663_abnormal_digestive_system0.96109756
70MP0006276_abnormal_autonomic_nervous0.94481840
71MP0001970_abnormal_pain_threshold0.94471647
72MP0003879_abnormal_hair_cell0.94114565
73MP0008469_abnormal_protein_level0.91987501
74MP0001485_abnormal_pinna_reflex0.91557981
75MP0003638_abnormal_response/metabolism_0.91168701
76MP0000230_abnormal_systemic_arterial0.90745976
77MP0002398_abnormal_bone_marrow0.89124771
78MP0001764_abnormal_homeostasis0.88226010
79MP0001666_abnormal_nutrient_absorption0.88130818
80MP0000631_abnormal_neuroendocrine_gland0.87133291
81MP0002733_abnormal_thermal_nociception0.86747361
82MP0000681_abnormal_thyroid_gland0.84497678
83MP0005332_abnormal_amino_acid0.84219155
84MP0005085_abnormal_gallbladder_physiolo0.83400538
85MP0008995_early_reproductive_senescence0.81794874
86MP0002282_abnormal_trachea_morphology0.81607168
87MP0005167_abnormal_blood-brain_barrier0.81213958
88MP0003195_calcinosis0.78737757
89MP0003806_abnormal_nucleotide_metabolis0.78645741
90MP0005166_decreased_susceptibility_to0.78229417
91MP0002429_abnormal_blood_cell0.77378486
92MP0009643_abnormal_urine_homeostasis0.77083022
93MP0001873_stomach_inflammation0.75513177
94MP0000689_abnormal_spleen_morphology0.74988159
95MP0001765_abnormal_ion_homeostasis0.74438903
96MP0005389_reproductive_system_phenotype0.73559325
97MP0003075_altered_response_to0.73289612
98MP0002272_abnormal_nervous_system0.73095794
99MP0008877_abnormal_DNA_methylation0.69288464
100MP0004947_skin_inflammation0.69150059

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.49410913
2Mitochondrial inheritance (HP:0001427)4.16155849
3Abnormal mitochondria in muscle tissue (HP:0008316)4.13122486
4Progressive macrocephaly (HP:0004481)3.80523116
5Elevated erythrocyte sedimentation rate (HP:0003565)3.79406710
6Acute encephalopathy (HP:0006846)3.79210614
7Hepatocellular necrosis (HP:0001404)3.61775338
8Increased CSF lactate (HP:0002490)3.51063690
9Partial duplication of thumb phalanx (HP:0009944)3.44518546
10Hepatic necrosis (HP:0002605)3.38038830
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18133760
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18133760
13Renal Fanconi syndrome (HP:0001994)3.14983633
143-Methylglutaconic aciduria (HP:0003535)3.12049911
15Generalized aminoaciduria (HP:0002909)3.05795589
16Cerebral edema (HP:0002181)3.00966059
17Increased intramyocellular lipid droplets (HP:0012240)3.00400222
18Partial duplication of the phalanx of hand (HP:0009999)2.96988036
19IgG deficiency (HP:0004315)2.92457099
20Stenosis of the external auditory canal (HP:0000402)2.88211765
21Conical tooth (HP:0000698)2.80499571
22Nausea (HP:0002018)2.77887005
23Abnormality of the heme biosynthetic pathway (HP:0010472)2.75957017
24Increased hepatocellular lipid droplets (HP:0006565)2.72534670
25Abnormality of the middle phalanges of the toes (HP:0010183)2.65562820
26Congenital stationary night blindness (HP:0007642)2.62126605
27Increased muscle lipid content (HP:0009058)2.61240343
28Chronic otitis media (HP:0000389)2.58130553
29Increased serum lactate (HP:0002151)2.52503667
30Lipid accumulation in hepatocytes (HP:0006561)2.51256709
31Lactic acidosis (HP:0003128)2.49829576
32Stomatitis (HP:0010280)2.47490853
33Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46878801
34Increased IgM level (HP:0003496)2.46806775
35Abnormality of magnesium homeostasis (HP:0004921)2.45394898
36Abnormality of alanine metabolism (HP:0010916)2.44595687
37Hyperalaninemia (HP:0003348)2.44595687
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44595687
39Aplastic anemia (HP:0001915)2.43565613
40Glycosuria (HP:0003076)2.42540415
41Abnormality of urine glucose concentration (HP:0011016)2.42540415
42Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.39907411
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.38925396
44Stomach cancer (HP:0012126)2.37875631
45Exertional dyspnea (HP:0002875)2.37436574
46Type II lissencephaly (HP:0007260)2.33812909
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32987533
48Optic disc pallor (HP:0000543)2.32606196
49Decreased central vision (HP:0007663)2.29831759
50True hermaphroditism (HP:0010459)2.29404011
51Megalencephaly (HP:0001355)2.25242822
52Petechiae (HP:0000967)2.24243661
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21813433
54Recurrent corneal erosions (HP:0000495)2.20320608
55Abnormality of the costochondral junction (HP:0000919)2.19708463
56Aplasia involving bones of the extremities (HP:0009825)2.19087593
57Aplasia involving bones of the upper limbs (HP:0009823)2.19087593
58Aplasia of the phalanges of the hand (HP:0009802)2.19087593
59Lethargy (HP:0001254)2.13288465
60Abnormality of the prostate (HP:0008775)2.05039772
61Congenital, generalized hypertrichosis (HP:0004540)2.02952081
62Abnormality of renal resorption (HP:0011038)2.02925065
63Hypomagnesemia (HP:0002917)2.01885541
64Humeroradial synostosis (HP:0003041)2.00736788
65Synostosis involving the elbow (HP:0003938)2.00736788
66Obstructive lung disease (HP:0006536)2.00476916
67Chronic obstructive pulmonary disease (HP:0006510)2.00476916
68Respiratory failure (HP:0002878)1.98814938
69Abnormal hemoglobin (HP:0011902)1.97871039
70Retinal dysplasia (HP:0007973)1.95016537
71Hypoplasia of the ulna (HP:0003022)1.94696948
72Abolished electroretinogram (ERG) (HP:0000550)1.94643711
73Pancreatitis (HP:0001733)1.93124579
74Abnormality of the labia minora (HP:0012880)1.88974594
75Myositis (HP:0100614)1.86370250
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85839241
77Pancreatic cysts (HP:0001737)1.85181937
78Hypoproteinemia (HP:0003075)1.85167345
79Symphalangism affecting the phalanges of the hand (HP:0009773)1.85078397
80Type 2 muscle fiber atrophy (HP:0003554)1.85031428
81Abnormality of midbrain morphology (HP:0002418)1.84440733
82Molar tooth sign on MRI (HP:0002419)1.84440733
83Congenital sensorineural hearing impairment (HP:0008527)1.80872957
84Optic neuritis (HP:0100653)1.80728458
85Retrobulbar optic neuritis (HP:0100654)1.80728458
86Exercise intolerance (HP:0003546)1.80593976
87Hyperphosphaturia (HP:0003109)1.79973302
88Leukodystrophy (HP:0002415)1.76942187
89Abnormality of the 2nd finger (HP:0004100)1.76289181
90Absent septum pellucidum (HP:0001331)1.75397694
91Abnormality of cells of the erythroid lineage (HP:0012130)1.75390129
92Respiratory distress (HP:0002098)1.73423476
93Hyperglycinemia (HP:0002154)1.70533983
94Encephalitis (HP:0002383)1.69996580
95Purpura (HP:0000979)1.69947665
96Attenuation of retinal blood vessels (HP:0007843)1.67395610
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66205970
98Dicarboxylic aciduria (HP:0003215)1.66205970
99Duplication of thumb phalanx (HP:0009942)1.66083711
100Methylmalonic aciduria (HP:0012120)1.65764978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.32283167
2TESK23.29992589
3TLK12.99337439
4PINK12.98813040
5KDR2.82314181
6BCKDK2.79316778
7MAP4K22.59062010
8TAOK32.48517350
9ADRBK22.34473409
10FGFR22.13834962
11CDK192.07466816
12GRK61.96815444
13STK161.85276972
14ZAK1.82589889
15GRK11.79525748
16NUAK11.73960465
17MAP4K11.66614255
18IKBKB1.63726309
19BMPR21.62859651
20MAPKAPK31.61009465
21MST41.54848117
22TEC1.48820854
23SYK1.45621883
24MYLK1.36475667
25LIMK11.36330918
26PIM21.29287370
27MAP3K111.28423752
28WNK41.21418021
29ITK1.19940150
30TIE11.18654426
31ACVR1B1.16529466
32BTK1.13291476
33MAP2K71.09965965
34FRK1.01441030
35NME11.00197621
36ZAP700.99356698
37LYN0.98616003
38RIPK40.97659462
39BLK0.97363370
40ADRBK10.95212026
41GRK70.94398326
42DYRK20.93959179
43MAP3K120.93835316
44FES0.93675835
45IKBKE0.87799289
46OXSR10.86345127
47MATK0.85031733
48KIT0.84842099
49BMPR1B0.83514683
50EPHB20.82877176
51JAK30.82779772
52ABL20.80821245
53PRKCQ0.80713370
54LCK0.78396529
55PHKG10.77639565
56PHKG20.77639565
57CSK0.74737394
58CSF1R0.74632240
59MUSK0.72505230
60OBSCN0.71303586
61PIM10.69421612
62MAP2K60.68434254
63RPS6KA50.68390473
64MINK10.66974921
65TNK20.66883192
66NME20.64406938
67PDK20.62895012
68ARAF0.62483310
69CSNK1G30.62460007
70PIK3CA0.62023552
71ILK0.61807329
72INSRR0.61407381
73PAK10.59594575
74CHUK0.56789955
75WNK30.55831312
76TBK10.55526708
77DYRK1B0.55251882
78MAP3K50.53440670
79PRKACA0.52461920
80ROCK10.51118988
81MAP3K60.49038973
82CSNK1G20.47702982
83VRK20.47560794
84DAPK20.46928459
85EIF2AK10.46106777
86MAPK130.44897667
87DAPK10.44473727
88IGF1R0.44049120
89PRKCA0.43614735
90TRIM280.42459559
91VRK10.42389836
92GRK50.42303429
93MARK30.40338995
94AKT30.40240908
95IRAK40.38065697
96PRKACG0.35840995
97CAMK2A0.35712633
98ABL10.34962551
99PRKCD0.34875861
100CSNK1A1L0.33072996

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.91462661
2Asthma_Homo sapiens_hsa053103.80440343
3Graft-versus-host disease_Homo sapiens_hsa053323.20661364
4Parkinsons disease_Homo sapiens_hsa050123.17505506
5Allograft rejection_Homo sapiens_hsa053303.13943238
6Autoimmune thyroid disease_Homo sapiens_hsa053203.07118199
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.82589684
8Proteasome_Homo sapiens_hsa030502.70653325
9Type I diabetes mellitus_Homo sapiens_hsa049402.66450435
10Ribosome_Homo sapiens_hsa030102.37137191
11Rheumatoid arthritis_Homo sapiens_hsa053232.17797888
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11011508
13Primary immunodeficiency_Homo sapiens_hsa053402.09322268
14Alzheimers disease_Homo sapiens_hsa050101.99354399
15Antigen processing and presentation_Homo sapiens_hsa046121.93775200
16Huntingtons disease_Homo sapiens_hsa050161.88165148
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77635190
18Cardiac muscle contraction_Homo sapiens_hsa042601.74080205
19Staphylococcus aureus infection_Homo sapiens_hsa051501.73416654
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72965191
21Hematopoietic cell lineage_Homo sapiens_hsa046401.65203223
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62610784
23Collecting duct acid secretion_Homo sapiens_hsa049661.62200832
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61820488
25Sulfur metabolism_Homo sapiens_hsa009201.57029319
26Linoleic acid metabolism_Homo sapiens_hsa005911.56268276
27Fat digestion and absorption_Homo sapiens_hsa049751.45817180
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41829422
29RNA polymerase_Homo sapiens_hsa030201.40917374
30Viral myocarditis_Homo sapiens_hsa054161.34862183
31Phototransduction_Homo sapiens_hsa047441.29006327
32Caffeine metabolism_Homo sapiens_hsa002321.28145940
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13864228
34Leishmaniasis_Homo sapiens_hsa051401.13845917
35Nitrogen metabolism_Homo sapiens_hsa009101.07701812
36Arachidonic acid metabolism_Homo sapiens_hsa005901.03362605
37Sulfur relay system_Homo sapiens_hsa041221.00304448
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98589692
39Malaria_Homo sapiens_hsa051440.98450976
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98273149
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.92282531
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92166756
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89798296
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86030383
45Peroxisome_Homo sapiens_hsa041460.86024510
46Mineral absorption_Homo sapiens_hsa049780.83259553
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81506844
48Chemical carcinogenesis_Homo sapiens_hsa052040.79237743
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76993528
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76959701
51Protein export_Homo sapiens_hsa030600.75644620
52Systemic lupus erythematosus_Homo sapiens_hsa053220.74617140
53Vitamin digestion and absorption_Homo sapiens_hsa049770.74014940
54Olfactory transduction_Homo sapiens_hsa047400.72207817
55Phagosome_Homo sapiens_hsa041450.71438258
56Glycerolipid metabolism_Homo sapiens_hsa005610.66598681
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65306913
58Ether lipid metabolism_Homo sapiens_hsa005650.64696136
59Glutathione metabolism_Homo sapiens_hsa004800.63111914
60Tuberculosis_Homo sapiens_hsa051520.61935848
61Regulation of autophagy_Homo sapiens_hsa041400.60541757
62Pyrimidine metabolism_Homo sapiens_hsa002400.60228977
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59965128
64Salmonella infection_Homo sapiens_hsa051320.58897659
65Butanoate metabolism_Homo sapiens_hsa006500.58038309
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.54763955
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53946739
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53342370
69Serotonergic synapse_Homo sapiens_hsa047260.52842911
70Retinol metabolism_Homo sapiens_hsa008300.52575118
71Morphine addiction_Homo sapiens_hsa050320.52299939
72One carbon pool by folate_Homo sapiens_hsa006700.50411325
73Metabolic pathways_Homo sapiens_hsa011000.49914766
74Purine metabolism_Homo sapiens_hsa002300.49206846
75T cell receptor signaling pathway_Homo sapiens_hsa046600.46120518
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.45652756
77Tryptophan metabolism_Homo sapiens_hsa003800.45455710
78Shigellosis_Homo sapiens_hsa051310.43248208
79Renin-angiotensin system_Homo sapiens_hsa046140.40885263
80Pertussis_Homo sapiens_hsa051330.40747791
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40593961
82Chemokine signaling pathway_Homo sapiens_hsa040620.40313768
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36543261
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.36470068
85GABAergic synapse_Homo sapiens_hsa047270.33219178
86Herpes simplex infection_Homo sapiens_hsa051680.31101242
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30267472
88Legionellosis_Homo sapiens_hsa051340.29552036
89Nicotine addiction_Homo sapiens_hsa050330.29498951
90Synaptic vesicle cycle_Homo sapiens_hsa047210.28711271
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.28285325
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25601533
93Arginine biosynthesis_Homo sapiens_hsa002200.24774714
94African trypanosomiasis_Homo sapiens_hsa051430.24201290
95Vibrio cholerae infection_Homo sapiens_hsa051100.21976449
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21901058
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21808004
98Homologous recombination_Homo sapiens_hsa034400.20003487
99Platelet activation_Homo sapiens_hsa046110.19394143
100Toxoplasmosis_Homo sapiens_hsa051450.19111816

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